AiPD: Autoinhibited Protein Database

P16298

Gene name	PPP3CB (CALNA2, CALNB, CNA2)
Protein name	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Names	CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit beta isoform, CNA beta
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5532
EC number	3.1.3.16: Phosphoric monoester hydrolases
Protein Class	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED (PTHR45673)

Descriptions

Calcium-dependent, calmodulin-stimulated protein phosphatase (PPP3CB) plays a role in the transduction of intracellular Ca2+-dependent signals in various cellular processes such as cardiac hypertrophy and T cell activation. This protein contains a novel autoinhibitory segment (AIS) in addition to the well-known autoinhibitory domain (AID). AIS and AID cooperatively inhibit enzyme activity.

Autoinhibitory domains (AIDs)

Target domain	93-293 (Calcineurin-like phosphoesterase domain)
Relief mechanism	Partner binding
Assay	Deletion assay, Mutagenesis experiment, Structural analysis

AID

416-423 (Autoinhibitory segment)

Target domain

93-293 (Calcineurin-like phosphoesterase domain)

Relief mechanism

Partner binding (CaM binding to CN)

Assay

Deletion assay, Mutagenesis experiment, Structural analysis

Target domain	93-293 (Calcineurin-like phosphoesterase domain)
Relief mechanism	Partner binding
Assay	Deletion assay, Mutagenesis experiment, Structural analysis

AID

476-500 (Autoinhibitory domain)

Target domain

93-293 (Calcineurin-like phosphoesterase domain)

Relief mechanism

Partner binding (CaM binding to CN)

Assay

Deletion assay, Mutagenesis experiment, Structural analysis

Accessory elements

No accessory elements

References

Li SJ et al. (2016) "Cooperative autoinhibition and multi-level activation mechanisms of calcineurin", Cell research, 26, 336-49

Autoinhibited structure

Activated structure

4 structures for P16298

Entry ID	Method	Resolution	Chain	Position	Source
4OR9	X-ray	223 A	A	1-524	PDB
4ORA	X-ray	275 A	A	1-524	PDB
4ORC	X-ray	270 A	A	1-524	PDB
AF-P16298-F1	Predicted				AlphaFoldDB

191 variants for P16298

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA594370719 rs1433272269	1	M>?		No	ClinGen gnomAD
CA377212845 rs1160414617	2	A>D		No	ClinGen gnomAD
CA377212841 rs1160414617	2	A>V		No	ClinGen gnomAD
rs1413995828 CA377212820	3	A>G		No	ClinGen gnomAD
rs1423121167 CA377212775	6	P>A		No	ClinGen TOPMed gnomAD
rs1423121167 CA377212777	6	P>T		No	ClinGen TOPMed gnomAD
rs1454870048 CA377212770	7	A>T		No	ClinGen gnomAD
rs1186461795 CA377212735	8	R>G		No	ClinGen TOPMed gnomAD
CA594370709 rs1466035701	8	R>RCV*		No	ClinGen gnomAD
rs1350196304 CA377212667	11	P>L		No	ClinGen gnomAD
CA377212672 rs1242667807	11	P>S		No	ClinGen gnomAD
rs1440236352 CA377212662	12	P>H		No	ClinGen TOPMed gnomAD
rs1440236352 CA377212652	12	P>L		No	ClinGen TOPMed gnomAD
CA377212664 rs1209277974	12	P>S		No	ClinGen TOPMed gnomAD
rs763806354 CA377212615	13	P>L		No	ClinGen ExAC gnomAD
rs763806354 CA5555745	13	P>Q		No	ClinGen ExAC gnomAD
rs763806354 CA377212617	13	P>R		No	ClinGen ExAC gnomAD
rs113693937 CA377212601	14	P>S		No	ClinGen TOPMed gnomAD
rs113693937 CA209646262	14	P>T		No	ClinGen TOPMed gnomAD
rs1364461760 CA377212573	15	P>L		No	ClinGen gnomAD
rs760374092 CA5555744	16	P>L		No	ClinGen ExAC gnomAD
CA377212567 rs1447907900	16	P>S		No	ClinGen gnomAD
CA377212545 rs1380769173	17	P>A		No	ClinGen TOPMed gnomAD
CA377212543 rs1403054215	17	P>L		No	ClinGen TOPMed
CA377212544 rs1380769173	17	P>S		No	ClinGen TOPMed gnomAD
rs773877963 CA5555740	20	P>L		No	ClinGen ExAC
rs1435361561 CA377212475	20	P>S		No	ClinGen gnomAD
CA5555738 rs771417243	21	P>S		No	ClinGen ExAC gnomAD
rs763382464 CA5555737	22	G>R		No	ClinGen ExAC TOPMed gnomAD
rs955115258 CA209646152	23	A>G		No	ClinGen TOPMed
CA377212436 rs773558588	23	A>P		No	ClinGen ExAC TOPMed gnomAD
CA5555736 rs773558588	23	A>S		No	ClinGen ExAC TOPMed gnomAD
rs769033884 CA5555732	29	A>T		No	ClinGen ExAC gnomAD
CA377209008 rs1181356023	30	V>L		No	ClinGen TOPMed gnomAD
rs1240894692 CA377208996	31	P>S		No	ClinGen TOPMed
CA377208983 rs1293118814	32	F>L		No	ClinGen gnomAD
rs780182113 CA5555707	32	F>S		No	ClinGen ExAC TOPMed gnomAD
rs1026496526 CA209633233	34	P>L		No	ClinGen Ensembl
CA5555706 rs772103811	34	P>T		No	ClinGen ExAC TOPMed gnomAD
rs749229440 CA5555705	37	R>C		No	ClinGen ExAC gnomAD
rs149808527 CA377208938 COSM1349011	37	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs149808527 CA5555704	37	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1207029573 CA377208927	38	L>F		No	ClinGen gnomAD
rs1415171094 CA377208903	40	S>F		No	ClinGen TOPMed
CA5555701 rs780975567	43	V>I		No	ClinGen ExAC gnomAD
CA5555698 rs573948169	46	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs138475102 CA5555699	46	L>S		No	ClinGen 1000Genomes ExAC gnomAD
CA5555697 rs762418445	47	D>V		No	ClinGen ExAC gnomAD
COSM23147 rs1333688207 CA377208748	50	P>L	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
CA5555696 rs749981068	53	D>E		No	ClinGen ExAC gnomAD
rs200220236 CA209633162	53	D>H		No	ClinGen Ensembl
CA377208701 rs1259419512	54	V>I		No	ClinGen gnomAD
rs760558486 CA209633147	56	K>R		No	ClinGen Ensembl
rs762423389 CA5555694	60	V>G		No	ClinGen ExAC gnomAD
CA377208563 rs1364238701	63	G>S		No	ClinGen TOPMed
CA209633127 rs866491225	64	R>*		No	ClinGen Ensembl
rs1385272859 CA377208546	64	R>L		No	ClinGen gnomAD
CA377208480 rs1386370575	69	I>M		No	ClinGen gnomAD
CA5555692 rs764624100	69	I>T		No	ClinGen ExAC gnomAD
rs371896052 CA5555693	69	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA209633080 rs1043627776	70	A>T		No	ClinGen Ensembl
rs1290520387 CA377208468 COSM3415240	70	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs772163544 CA5555689	75	N>S		No	ClinGen ExAC TOPMed gnomAD
CA377208388 COSM381300 rs1465995395	77	G>V	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
CA209633052 rs1012003058	79	A>V		No	ClinGen Ensembl
rs745892650 CA5555688	82	R>Q		No	ClinGen ExAC gnomAD
CA377208329 rs1173573690	82	R>W		No	ClinGen gnomAD
CA5555687 rs774509144	86	T>I		No	ClinGen ExAC gnomAD
rs769657167 CA5555686	87	M>I		No	ClinGen ExAC gnomAD
CA377208224 rs1194657674	87	M>V		No	ClinGen gnomAD
CA377208197 rs1209021609	88	I>V		No	ClinGen TOPMed
rs1260286948 CA377208163	89	E>D		No	ClinGen TOPMed gnomAD
rs1207382771 CA377208153	90	V>L		No	ClinGen gnomAD
CA377208130 rs1486256060	91	E>A		No	ClinGen gnomAD
CA5555685 rs748078649	91	E>D		No	ClinGen ExAC TOPMed gnomAD
CA209633022 rs368077062	94	I>V		No	ClinGen ESP TOPMed gnomAD
rs762470155 COSM1349009 CA209632677	106	D>Y	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
CA5555666 rs748064202	108	M>V		No	ClinGen ExAC gnomAD
rs776597343 CA5555665	111	F>L		No	ClinGen ExAC TOPMed gnomAD
CA377207667 rs1307064637	119	N>S		No	ClinGen gnomAD
CA209632656 rs753926654	120	T>I		No	ClinGen Ensembl
rs1214845353 CA377207652	121	R>*		No	ClinGen TOPMed
rs199899901 CA5555664	121	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA209632646 rs74453476	129	V>L		No	ClinGen Ensembl
rs1186369101 CA377207487	136	I>V		No	ClinGen gnomAD
rs1247371570 CA377206779	138	C>S		No	ClinGen gnomAD
rs1342340591 CA377206728	141	Y>H		No	ClinGen gnomAD
rs1326788338 CA377206657	144	V>L		No	ClinGen TOPMed
CA5555629 rs755417639	151	S>T		No	ClinGen ExAC gnomAD
rs1199581042 CA377206378	158	G>D		No	ClinGen gnomAD
CA5555627 rs766547904	163	R>K		No	ClinGen ExAC gnomAD
CA377206147 rs1372152615	167	E>G		No	ClinGen gnomAD
rs1429231333 CA377205987	174	E>D		No	ClinGen gnomAD
rs1213117450 CA377204953	176	K>R		No	ClinGen gnomAD
rs1336058802 CA377204878	179	Y>C		No	ClinGen TOPMed
rs1414271750 CA377204853	181	E>Q		No	ClinGen TOPMed gnomAD
CA377204797 rs1435566336	184	Y>C		No	ClinGen gnomAD
rs962196869 CA209628034	185	E>G		No	ClinGen Ensembl
CA209628022 rs892282104	187	C>S		No	ClinGen TOPMed
CA377204722 rs1420181378	188	M>I		No	ClinGen gnomAD
rs753897852 CA5555604	188	M>L		No	ClinGen ExAC TOPMed gnomAD
rs1187107298 COSM920309 CA377204628	193	S>C	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1188282358 CA377204474	202	Q>E		No	ClinGen gnomAD
CA377204431 rs1194484544	204	F>V		No	ClinGen TOPMed
CA377204409 rs1258849253 COSM920308	205	L>I	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1032604343 CA209628018	215	I>V		No	ClinGen TOPMed gnomAD
CA5555602 rs759556518	216	H>N		No	ClinGen ExAC gnomAD
CA377204122 rs759556518	216	H>Y		No	ClinGen ExAC gnomAD
rs1448901517 CA377204037	220	D>A		No	ClinGen gnomAD
CA5555601 rs774219136	220	D>N		No	ClinGen ExAC gnomAD
CA377204001 rs1274385408	222	R>G		No	ClinGen gnomAD
rs1233179084 CA377203990	222	R>K		No	ClinGen gnomAD
rs1564561831 CA377203978	223	R>G		No	ClinGen Ensembl
rs1472878143 CA377203725	225	D>G		No	ClinGen TOPMed
CA377203639 rs1234014189	228	K>R		No	ClinGen gnomAD
CA209627893 rs202139360	229	E>D		No	ClinGen TOPMed
CA377203448 rs1340780399	235	P>A		No	ClinGen TOPMed gnomAD
rs373930579 CA377203414	236	M>L		No	ClinGen ESP TOPMed gnomAD
CA209627886 rs373930579	236	M>V		No	ClinGen ESP TOPMed gnomAD
CA209627862 rs755603004	250	N>H		No	ClinGen Ensembl
CA209627857 rs200953530	250	N>S		No	ClinGen gnomAD
rs751602460 CA5555580	251	E>G		No	ClinGen ExAC gnomAD
CA209627845 rs956430664	255	E>A		No	ClinGen TOPMed
CA209627841 rs973638905	256	H>R		No	ClinGen Ensembl
CA377202798 rs1361529412	260	N>S		No	ClinGen gnomAD
CA209627840 rs962312824	263	R>Q		No	ClinGen Ensembl
rs1141282 CA209627839 COSM427884	266	S>F	breast [Cosmic]	No	ClinGen cosmic curated Ensembl
CA209627837 rs1134796	267	Y>F		No	ClinGen Ensembl
CA377202592 rs1422367208	271	Y>F		No	ClinGen TOPMed
CA209627771 rs1023387956	272	P>S		No	ClinGen TOPMed
rs1374511730 CA377202561	273	A>T		No	ClinGen gnomAD
rs777893115 CA5555563	274	V>M		No	ClinGen ExAC gnomAD
CA377202385 rs1397264033	280	N>S		No	ClinGen gnomAD
rs1410869274 CA377202113	292	A>S		No	ClinGen TOPMed
CA377201926 rs1484234762	302	K>Q		No	ClinGen TOPMed
CA377201841 rs1254900458	309	P>R		No	ClinGen TOPMed
CA377201797 rs1416014960	312	I>M		No	ClinGen gnomAD
CA5555539 COSM1349006 rs757043989	316	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC
rs1327709109 CA377201714	319	N>D		No	ClinGen gnomAD
CA377201654 rs1170061261	323	V>I		No	ClinGen TOPMed
rs1391228775 CA377201630	325	N>H		No	ClinGen gnomAD
CA209625845 rs200425456	330	V>I		No	ClinGen 1000Genomes gnomAD
CA377200784 rs200425456	330	V>L		No	ClinGen 1000Genomes gnomAD
CA5555512 rs574786999	335	N>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766987677 CA5555511	336	N>D		No	ClinGen ExAC gnomAD
rs1331815036 CA377200631	336	N>S		No	ClinGen gnomAD
rs751108387 CA5555509	341	R>Q		No	ClinGen ExAC gnomAD
rs1433910572 CA377200018	356	M>I		No	ClinGen gnomAD
rs766744885 CA5555508	356	M>T		No	ClinGen ExAC gnomAD
CA377199912 rs1195485046	360	T>M		No	ClinGen gnomAD
CA5555485 rs139659278	373	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs762229258 CA5555483	375	V>A		No	ClinGen ExAC gnomAD
CA5555482 rs777159200	385	E>K		No	ClinGen ExAC gnomAD
rs1268928101 CA377196042	387	M>I		No	ClinGen TOPMed
rs565278043 CA5555436	397	S>A		No	ClinGen 1000Genomes ExAC gnomAD
CA5555435 rs759770575	399	A>T		No	ClinGen ExAC gnomAD
rs1354218930 CA377194382	399	A>V		No	ClinGen gnomAD
rs751574172 CA5555434	401	R>W		No	ClinGen ExAC gnomAD
CA377194299 rs546930537	412	I>F		No	ClinGen 1000Genomes ExAC gnomAD
rs546930537 CA5555432	412	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1359217754 CA377194266	416	A>V		No	ClinGen gnomAD
rs1400216413 CA377194239	420	S>F		No	ClinGen gnomAD
rs1404791686 CA377225483	427	E>A		No	ClinGen gnomAD
rs1236180758 CA377225308	445	V>L		No	ClinGen TOPMed
CA5555413 rs758464886	450	R>W		No	ClinGen ExAC TOPMed gnomAD
CA377225226 rs1437538750	454	Q>R		No	ClinGen gnomAD
rs751426214 CA5555385	461	I>T		No	ClinGen ExAC TOPMed gnomAD
CA5555386 rs759360490	461	I>V		No	ClinGen ExAC gnomAD
rs766002414 CA5555384	465	K>R		No	ClinGen ExAC gnomAD
rs61749234 CA5555373	468	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1564545041 CA377223185	471	S>F		No	ClinGen Ensembl
rs1305175476 CA377222908	483	K>R		No	ClinGen TOPMed
rs753997606 CA5555370	495	R>W		No	ClinGen ExAC gnomAD
rs781230329 CA5555369	497	D>G		No	ClinGen ExAC gnomAD
CA209629731 rs956064020	500	Q>H		No	ClinGen TOPMed gnomAD
rs1342647320 CA377222343	506	S>Y		No	ClinGen gnomAD
CA5555362 rs756307973	510	A>T		No	ClinGen ExAC TOPMed gnomAD
rs550798579 CA5555361	512	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA377222134 rs1167941200	513	T>I		No	ClinGen gnomAD
rs1399380706 CA377222145	513	T>P		No	ClinGen gnomAD
rs372419696 CA5555360	514	E>K		No	ClinGen ESP ExAC gnomAD
rs775907792 CA5555358	517	G>R		No	ClinGen ExAC TOPMed gnomAD
CA377222025 rs775907792	517	G>W		No	ClinGen ExAC TOPMed gnomAD
CA5555357 rs746120729	518	T>M		No	ClinGen ExAC TOPMed gnomAD
CA5555355 rs778959729	520	N>H		No	ClinGen ExAC gnomAD
CA5555354 rs564975960	521	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA377221917 rs1257935972	522	T>A		No	ClinGen gnomAD
CA5555353 rs749327107	522	T>I		No	ClinGen ExAC gnomAD
CA377221911 rs749327107	522	T>S		No	ClinGen ExAC gnomAD
CA209629683 rs1000041539	524	Q>*		No	ClinGen TOPMed
COSM1505706 CA377221875 rs1320067384	524	Q>L	lung [Cosmic]	No	ClinGen cosmic curated gnomAD

No associated diseases with P16298

3 regional properties for P16298

Type	Name	Position	InterPro Accession
domain	Calcineurin-like phosphoesterase domain, ApaH type	93 - 293	IPR004843
domain	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	65 - 356	IPR006186
domain	PP2B, metallophosphatase domain	50 - 354	IPR041751

Functions

		Description
EC Number	3.1.3.16	Phosphoric monoester hydrolases
Subcellular Localization	Cytoplasm
PANTHER Family	PTHR45673	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
PANTHER Subfamily	PTHR45673:SF7	SERINE_THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
PANTHER Protein Class	protein phosphatase protein modifying enzyme
PANTHER Pathway Category	T cell activation Calcineurin Wnt signaling pathway Calcineurin B cell activation Calcineurin

8 GO annotations of cellular component

Name	Definition
calcineurin complex	A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
T-tubule	Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
Z disc	Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

7 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein phosphatase activity	Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
protein dimerization activity	The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
protein phosphatase 2B binding	Binding to a protein phosphatase 2B.
protein serine/threonine phosphatase activity	Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

25 GO annotations of biological process

Name	Definition
axon extension	Long distance growth of a single axon process involved in cellular development.
calcineurin-mediated signaling	Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression.
calcineurin-NFAT signaling cascade	Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
calcium-ion regulated exocytosis	The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
dephosphorylation	The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
heart development	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
learning	Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
locomotion involved in locomotory behavior	Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
lymphangiogenesis	Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
memory	The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
negative regulation of T cell mediated cytotoxicity	Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
positive regulation of insulin secretion involved in cellular response to glucose stimulus	Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of transcription, DNA-templated	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of insulin secretion	Any process that modulates the frequency, rate or extent of the regulated release of insulin.
regulation of synaptic plasticity	A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
regulation of synaptic vesicle endocytosis	Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
response to cytokine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
T cell activation	The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
T cell differentiation	The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
T cell homeostasis	The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
T cell proliferation	The expansion of a T cell population by cell division. Follows T cell activation.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P23287	CNA1	Serine/threonine-protein phosphatase 2B catalytic subunit A1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P48452	PPP3CA	Protein phosphatase 3 catalytic subunit alpha	Bos taurus (Bovine)	SS
Q27889	Pp2B-14D	Serine/threonine-protein phosphatase 2B catalytic subunit 2	Drosophila melanogaster (Fruit fly)	SS
P48456	CanA1	Serine/threonine-protein phosphatase 2B catalytic subunit 1	Drosophila melanogaster (Fruit fly)	SS
Q9VXF1	CanA-14F	Serine/threonine-protein phosphatase 2B catalytic subunit 3	Drosophila melanogaster (Fruit fly)	SS
P48454	PPP3CC	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	Homo sapiens (Human)	SS
Q08209	PPP3CA	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Homo sapiens (Human)	EV
P48455	Ppp3cc	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	Mus musculus (Mouse)	PR
P63328	Ppp3ca	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Mus musculus (Mouse)	EV
P48453	Ppp3cb	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	Mus musculus (Mouse)	SS
P63329	Ppp3ca	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Rattus norvegicus (Rat)	SS
P20651	Ppp3cb	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	Rattus norvegicus (Rat)	SS
Q0G819	tax-6	Serine/threonine-protein phosphatase 2B catalytic subunit	Caenorhabditis elegans	SS

10	20	30	40	50	60
MAAPEPARAA	PPPPPPPPPP	PGADRVVKAV	PFPPTHRLTS	EEVFDLDGIP	RVDVLKNHLV
70	80	90	100	110	120
KEGRVDEEIA	LRIINEGAAI	LRREKTMIEV	EAPITVCGDI	HGQFFDLMKL	FEVGGSPANT
130	140	150	160	170	180
RYLFLGDYVD	RGYFSIECVL	YLWVLKILYP	STLFLLRGNH	ECRHLTEYFT	FKQECKIKYS
190	200	210	220	230	240
ERVYEACMEA	FDSLPLAALL	NQQFLCVHGG	LSPEIHTLDD	IRRLDRFKEP	PAFGPMCDLL
250	260	270	280	290	300
WSDPSEDFGN	EKSQEHFSHN	TVRGCSYFYN	YPAVCEFLQN	NNLLSIIRAH	EAQDAGYRMY
310	320	330	340	350	360
RKSQTTGFPS	LITIFSAPNY	LDVYNNKAAV	LKYENNVMNI	RQFNCSPHPY	WLPNFMDVFT
370	380	390	400	410	420
WSLPFVGEKV	TEMLVNVLSI	CSDDELMTEG	EDQFDGSAAA	RKEIIRNKIR	AIGKMARVFS
430	440	450	460	470	480
VLREESESVL	TLKGLTPTGM	LPSGVLAGGR	QTLQSATVEA	IEAEKAIRGF	SPPHRICSFE
490	500	510	520
EAKGLDRINE	RMPPRKDAVQ	QDGFNSLNTA	HATENHGTGN	HTAQ