AiPD: Autoinhibited Protein Database

P15813

Gene name	CD1D
Protein name	Antigen-presenting glycoprotein CD1d
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:912
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

33-116 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

33-116 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

20 structures for P15813

Entry ID	Method	Resolution	Chain	Position	Source
1ZT4	X-ray	300 A	A/C	19-299	PDB
2PO6	X-ray	320 A	A/E	24-295	PDB
3HUJ	X-ray	250 A	A/C	21-295	PDB
3SDX	X-ray	312 A	A/C	24-295	PDB
3TZV	X-ray	306 A	C	21-295	PDB
3U0P	X-ray	280 A	A/C/E	21-295	PDB
3VWJ	X-ray	309 A	A	21-295	PDB
3VWK	X-ray	294 A	A	21-295	PDB
4EN3	X-ray	257 A	C	21-295	PDB
4LHU	X-ray	287 A	A	24-295	PDB
4MNG	X-ray	301 A	A/C	21-201	PDB
4MQ7	X-ray	260 A	A	21-202	PDB
4WO4	X-ray	250 A	A	24-295	PDB
4WW2	X-ray	248 A	C	21-295	PDB
4WWK	X-ray	310 A	C	21-295	PDB
6V7Y	X-ray	240 A	A	23-296	PDB
6V7Z	X-ray	275 A	A/C	23-296	PDB
6V80	X-ray	353 A	A/F	23-296	PDB
8SOS	X-ray	233 A	A/E	23-296	PDB
AF-P15813-F1	Predicted				AlphaFoldDB

322 variants for P15813

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1413615456 CA342984549 COSM897672	2	G>R	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs967067063 CA342984570	3	C>S		No	ClinGen TOPMed gnomAD
rs967067063 CA31217353	3	C>Y		No	ClinGen TOPMed gnomAD
CA31217360 rs1004363577	5	L>P		No	ClinGen Ensembl
rs746264656 CA1177963	7	L>M		No	ClinGen ExAC gnomAD
CA342984623 rs1354699291	7	L>P		No	ClinGen gnomAD
rs1421587364 CA342984636	9	L>F		No	ClinGen TOPMed
CA342984635 rs1421587364	9	L>V		No	ClinGen TOPMed
CA1177965 rs575858932	11	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA31217471 rs955133347	13	L>F		No	ClinGen TOPMed
rs768289152 CA1177969	14	Q>*		No	ClinGen ExAC
CA1177970 rs776132124	15	A>P		No	ClinGen ExAC
CA31217493 rs1030947818	16	W>C		No	ClinGen Ensembl
rs761264753 CA1177971	16	W>G		No	ClinGen ExAC TOPMed gnomAD
CA342984735 rs761264753	16	W>R		No	ClinGen ExAC TOPMed gnomAD
rs1181570854 CA342984748	17	G>R		No	ClinGen gnomAD
rs986366494 CA31217499	21	V>I		No	ClinGen TOPMed gnomAD
rs986366494 CA342984825	21	V>L		No	ClinGen TOPMed gnomAD
CA1177991 rs563464986	24	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762862302 CA1177992	26	F>L		No	ClinGen ExAC TOPMed gnomAD
rs765927009 CA1177993	27	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA342985515 rs1424286438	28	L>F		No	ClinGen gnomAD
CA342985513 rs1424286438	28	L>I		No	ClinGen gnomAD
CA342985521 rs1467075339	29	R>C		No	ClinGen TOPMed gnomAD
rs1162545934 CA342985534	31	L>F		No	ClinGen TOPMed gnomAD
CA342985533 rs1162545934	31	L>I		No	ClinGen TOPMed gnomAD
CA342985543 rs1571063260	32	Q>R		No	ClinGen Ensembl
rs774026057 CA1177994	33	I>S		No	ClinGen ExAC gnomAD
TCGA novel	34	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1177995 rs759322259	35	S>F		No	ClinGen ExAC gnomAD
rs764442092 CA1177996	36	F>L		No	ClinGen ExAC TOPMed gnomAD
CA342985578 rs1224733607	38	N>D		No	ClinGen TOPMed
CA1177998 rs145764530	38	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs534777032 CA1177997	38	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs765463924 CA1178000	41	W>R		No	ClinGen ExAC gnomAD
rs150689409 CA1178001	41	W>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA342985606 rs1417307672	42	T>P		No	ClinGen TOPMed
CA1178003 rs780562127	43	R>C	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1178004 rs571302746	43	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA342985620 rs1404587858	44	T>S		No	ClinGen TOPMed
rs755379238 CA1178005	45	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA342985631 rs1412947803	46	G>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1178009 rs769435157	48	A>T		No	ClinGen ExAC
TCGA novel	49	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1178011 rs147976430 RCV000898682	49	W>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1298885559 CA342985663	51	G>A		No	ClinGen gnomAD
rs1298885559 CA342985661	51	G>E		No	ClinGen gnomAD
rs754739489 CA31217921	51	G>R		No	ClinGen TOPMed gnomAD
rs754739489 CA31217923	51	G>W		No	ClinGen TOPMed gnomAD
CA1178012 rs770791482	52	E>*		No	ClinGen ExAC TOPMed gnomAD
rs774300975 CA31217927	52	E>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	52	E>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1178013 rs774300975	52	E>V		No	ClinGen ExAC TOPMed gnomAD
rs1558043720 CA342985670	53	L>V		No	ClinGen Ensembl
CA342985677 rs1571063584	54	Q>P		No	ClinGen Ensembl
CA342985683 rs759359465	55	T>A		No	ClinGen ExAC gnomAD
rs150540703 CA1178015 COSM239221	55	T>M	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA1178014 rs759359465	55	T>S		No	ClinGen ExAC gnomAD
rs775409915 CA1178016	56	H>N		No	ClinGen ExAC gnomAD
CA31217935 rs369994630	57	S>R		No	ClinGen ESP TOPMed
rs1238892190 CA342985715	59	S>R		No	ClinGen gnomAD
CA342985723 rs1286282747	60	N>K		No	ClinGen TOPMed gnomAD
CA1178017 rs762132850	61	D>N		No	ClinGen ExAC gnomAD
COSM1498718 rs765499678 CA1178018	62	S>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA342985746 rs62621276	64	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1178019 VAR_010211 rs62621276 RCV000955795	64	T>S		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA342985754 rs1483508575	65	V>A		No	ClinGen gnomAD
CA1178020 rs139809600	66	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1178021 rs373808437	66	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs764778150 CA31217988	67	S>F		No	ClinGen Ensembl
CA342985777 rs1438843876	69	K>N		No	ClinGen gnomAD
CA31217992 rs868344809	72	S>F		No	ClinGen gnomAD
CA1178023 rs755467075	73	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA31218015 rs751998026	77	S>I		No	ClinGen ExAC gnomAD
CA1178024 rs751998026	77	S>N		No	ClinGen ExAC gnomAD
rs755775062 CA1178026	78	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1178028 rs757525630	79	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA342985902 rs1309581816	80	Q>E		No	ClinGen gnomAD
CA342985905 rs1355355544	80	Q>R		No	ClinGen gnomAD
rs773711451 CA1178031	81	W>*		No	ClinGen ExAC TOPMed gnomAD
rs773711451 CA1178030	81	W>C		No	ClinGen ExAC TOPMed gnomAD
CA31218033 rs770514010	81	W>G		No	ClinGen ExAC gnomAD
CA1178029 rs770514010	81	W>R		No	ClinGen ExAC gnomAD
CA342985943 rs1418909519	86	H>D		No	ClinGen TOPMed
rs1457194054 CA342985950	87	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA342985965 COSM3802348 rs920079330	89	R>W	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA342985971 rs1425794734	90	V>F		No	ClinGen TOPMed
TCGA novel	92	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1178035 rs770171229	92	R>G		No	ClinGen ExAC gnomAD
CA31218104 rs1049934456	94	S>G		No	ClinGen Ensembl
CA342985998 rs1240298917	94	S>T		No	ClinGen gnomAD
rs773523873 CA1178036	95	F>C		No	ClinGen ExAC gnomAD
rs763067209 CA1178037	96	T>A		No	ClinGen ExAC TOPMed gnomAD
CA342986017 rs1425881954	97	R>T		No	ClinGen gnomAD
CA342986025 rs1488479163	98	D>G		No	ClinGen TOPMed
COSM1247663 CA342986029 rs1245473930	99	V>M	oesophagus Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA1178039 rs200638686	100	K>M		No	ClinGen 1000Genomes ExAC gnomAD
CA1178041 rs540329660	100	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA342986057 rs1469165638	103	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA342986069 rs1378667244	104	K>N		No	ClinGen gnomAD
CA31218126 rs947265466	104	K>R		No	ClinGen TOPMed
CA1178043 rs756425870	106	L>R		No	ClinGen ExAC gnomAD
rs1433771195 CA342986079	106	L>V		No	ClinGen gnomAD
rs1220430860 CA342986086	107	R>H		No	ClinGen gnomAD
CA1178046 rs145209409	108	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1199062111	109	S>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs199803276 CA31218459	112	L>S		No	ClinGen 1000Genomes TOPMed gnomAD
CA1178072 rs747843388	113	E>A		No	ClinGen ExAC gnomAD
rs1243821135 CA342986156	116	V>L		No	ClinGen gnomAD
CA342986161 rs1284508937	117	S>P		No	ClinGen gnomAD
rs142254126 CA1178073	118	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142254126 CA31218486	118	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA342986170 rs1295329954	119	G>S		No	ClinGen TOPMed
rs1488686000 CA342986201	123	H>P		No	ClinGen gnomAD
CA342986224 rs772184982	126	N>K		No	ClinGen ExAC TOPMed gnomAD
CA31218541 rs376234152	129	N>D		No	ClinGen ESP gnomAD
rs376234152 CA342986238	129	N>H		No	ClinGen ESP gnomAD
CA342986239 rs376234152	129	N>Y		No	ClinGen ESP gnomAD
TCGA novel	130	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1558044142 CA342986245	130	N>Y		No	ClinGen Ensembl
CA1178077 rs775533162 COSM414416	131	F>L	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1296914455 CA342986254	131	F>V		No	ClinGen TOPMed
CA342986256 rs1482929947	131	F>Y		No	ClinGen gnomAD
rs764439411 CA342986265 CA1178079	132	F>L		No	ClinGen ExAC TOPMed gnomAD
rs761312127 CA1178078	132	F>Y		No	ClinGen ExAC gnomAD
rs777065653 CA1178081	133	H>L		No	ClinGen ExAC gnomAD
rs777065653 CA1178080	133	H>R		No	ClinGen ExAC gnomAD
rs750151889 CA1178083	134	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	135	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1178085 rs149673076	137	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1473022956 CA342986323	141	I>N		No	ClinGen TOPMed gnomAD
CA342986337 rs1308853719	143	S>I		No	ClinGen gnomAD
CA31218640 rs141459313	145	Q>P		No	ClinGen ESP
CA31218659 rs866317924	146	G>E		No	ClinGen Ensembl
rs748002385 CA342986355 CA1178089	146	G>R		No	ClinGen ExAC gnomAD
TCGA novel	146	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1201598310 CA342986364	147	T>I		No	ClinGen TOPMed gnomAD
CA342986363 rs1201598310	147	T>S		No	ClinGen TOPMed gnomAD
CA1178092 rs150267466	150	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs777519162 COSM1601017 CA1178091	150	E>K	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA342986396 rs1359105831	152	T>I		No	ClinGen TOPMed gnomAD
CA342986397 rs1359105831	152	T>N		No	ClinGen TOPMed gnomAD
CA31218695 rs944463487	153	Q>E		No	ClinGen Ensembl
CA342986410 rs1237224499	154	E>D		No	ClinGen TOPMed gnomAD
rs112389115 CA31218702	154	E>G		No	ClinGen Ensembl
rs1439861535 CA342986414	155	A>S		No	ClinGen gnomAD
rs1276312770 CA342986420	156	P>S		No	ClinGen TOPMed
CA342986444 rs1229698345	159	V>G		No	ClinGen TOPMed
rs775551491 CA1178095	160	N>H		No	ClinGen ExAC gnomAD
CA342986453 COSM1247665 rs1173138241	161	L>V	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1463895346 CA342986464	162	A>V		No	ClinGen gnomAD
CA1178097 rs769237588	164	Q>R		No	ClinGen ExAC gnomAD
CA31218720 rs573460385	166	L>H		No	ClinGen Ensembl
rs569192974 CA1178099	166	L>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1234034510 CA342986514	170	K>E		No	ClinGen gnomAD
CA1178102 COSM463196 rs536931854	172	T>K	kidney Variant assessed as Somatic; 0.0003234 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs536931854 CA1178101	172	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs555012544 CA1178103	175	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1178104 rs751106209	176	V>E		No	ClinGen ExAC gnomAD
rs1464715218 CA342986565	177	Q>H		No	ClinGen TOPMed
rs754401833 CA1178105	178	W>*		No	ClinGen ExAC gnomAD
rs754401833 CA1178106 CA342986573	178	W>C		No	ClinGen ExAC gnomAD
CA342986569 rs1259029374	178	W>G		No	ClinGen gnomAD
CA342986591 rs1197239916	181	N>I		No	ClinGen TOPMed gnomAD
CA342986590 rs1197239916	181	N>S		No	ClinGen TOPMed gnomAD
rs370390485 CA1178109	182	G>A		No	ClinGen ESP ExAC gnomAD
rs756062333 CA1178108	182	G>C		No	ClinGen ExAC TOPMed gnomAD
CA342986594 rs756062333	182	G>S		No	ClinGen ExAC TOPMed gnomAD
CA31218821 rs934301784	185	P>L		No	ClinGen Ensembl
CA342986619 rs1369461190	186	Q>*		No	ClinGen gnomAD
CA1178111 rs758632260	187	F>I		No	ClinGen ExAC TOPMed gnomAD
rs780199550 CA1178112	190	G>C		No	ClinGen ExAC gnomAD
CA1178113 rs747224165	190	G>D		No	ClinGen ExAC gnomAD
rs768667642 CA1178114	191	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	191	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781320176 CA1178115	192	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA342986673 rs1553250499	194	S>L		No	ClinGen Ensembl
rs770361108 CA1178117	195	G>A		No	ClinGen ExAC gnomAD
rs1387458914 CA342986674	195	G>R		No	ClinGen gnomAD
CA1178118 rs773729311	196	K>R		No	ClinGen ExAC TOPMed gnomAD
CA342986689 rs149463702	197	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA1178119 rs149463702	197	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs759201645 CA31218915	198	E>*		No	ClinGen ExAC TOPMed gnomAD
rs759201645 CA1178122	198	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	200	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1487925959 CA342986726	203	V>M		No	ClinGen gnomAD
CA342986757 rs1195945025	205	P>H		No	ClinGen TOPMed
TCGA novel	206	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	206	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1178158 rs756299315	207	A>S		No	ClinGen ExAC TOPMed gnomAD
rs756299315 COSM1335139 CA31219403	207	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA342986767 rs1237218636	207	A>V		No	ClinGen TOPMed
rs1571066666 CA342986774	208	W>L		No	ClinGen Ensembl
CA31219415 rs566569460	208	W>R		No	ClinGen gnomAD
rs1175071315 CA342986781	209	L>P		No	ClinGen TOPMed
rs750887347 CA1178160	211	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs757831900 CA1178161	211	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs757831900 CA342986792	211	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1342871267 CA342986793	212	G>C		No	ClinGen TOPMed gnomAD
CA342986796 rs1558044864	212	G>D		No	ClinGen Ensembl
TCGA novel	214	S>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs539075437 CA31219439	216	G>D		No	ClinGen gnomAD
COSM1335140 CA1178163 rs147417067	218	G>D	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
COSM1644482 CA1178165 rs775167221	219	R>C	NS [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs199860570 CA1178166	219	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs768212638 CA1178167	220	L>P		No	ClinGen ExAC gnomAD
CA1178169 CA342986854 rs761745102	223	V>L		No	ClinGen ExAC TOPMed gnomAD
rs765167318 CA1178170	224	C>W		No	ClinGen ExAC TOPMed gnomAD
rs772906466 CA1178171	225	H>P		No	ClinGen ExAC gnomAD
TCGA novel	227	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766059814 CA1178173	228	G>R		No	ClinGen ExAC gnomAD
CA342986903 rs1466445844	230	Y>*		No	ClinGen gnomAD
rs569233577 CA1178175	231	P>R		No	ClinGen 1000Genomes ExAC gnomAD
CA342986922 rs1355878184	233	P>L		No	ClinGen gnomAD
rs1433700746 CA342986924	234	V>I		No	ClinGen TOPMed gnomAD
TCGA novel CA342986940 rs1346074244	236	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD
rs764333911 CA1178177	238	W>*		No	ClinGen ExAC gnomAD
rs1022444364 CA31219516	239	M>T		No	ClinGen TOPMed gnomAD
rs779426050 CA1178181	240	R>L		No	ClinGen ExAC TOPMed gnomAD
rs779426050 CA31219543	240	R>P		No	ClinGen ExAC TOPMed gnomAD
CA1178180 rs779426050	240	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs139209490 CA1178178	240	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1178183 rs367746380	241	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs367746380 CA1178184	241	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs758837390 CA1178182	241	G>S		No	ClinGen ExAC
TCGA novel	242	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA31219557 rs149772303 CA1178185	242	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1178187 rs776133854	244	E>V		No	ClinGen ExAC TOPMed gnomAD
CA342986998 rs1487841401	245	Q>R		No	ClinGen TOPMed
rs948414574 CA31219605	246	Q>*		No	ClinGen Ensembl
rs773245435 CA1178191	247	G>A		No	ClinGen ExAC gnomAD
rs1240900532 CA342987009	247	G>S		No	ClinGen TOPMed
CA1178192 rs762773829	248	T>I		No	ClinGen ExAC TOPMed gnomAD
CA1178193 rs766250843	250	P>Q		No	ClinGen ExAC gnomAD
rs1406224009 CA342987035	251	G>E		No	ClinGen gnomAD
CA1178195 rs748004286	252	D>N		No	ClinGen ExAC gnomAD
rs748004286 CA342987039	252	D>Y		No	ClinGen ExAC gnomAD
CA1178196 rs764352305	253	I>F		No	ClinGen ExAC gnomAD
CA1178197 rs764352305	253	I>V		No	ClinGen ExAC gnomAD
rs757319382 CA1178198	254	L>M		No	ClinGen ExAC TOPMed gnomAD
CA1178199 rs371913497	255	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs750996933 CA31219705	256	N>I		No	ClinGen ExAC TOPMed gnomAD
CA1178200 rs750996933	256	N>S		No	ClinGen ExAC TOPMed gnomAD
CA1178201 rs758827375	258	D>G		No	ClinGen ExAC gnomAD
CA1178203 COSM1335141 rs182855664	259	E>K	large_intestine Variant assessed as Somatic; 4.619e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs754650454 CA1178204	260	T>I		No	ClinGen ExAC TOPMed gnomAD
CA342987098 rs1448022182	261	W>C		No	ClinGen gnomAD
CA342987095 rs1287550250	261	W>L		No	ClinGen TOPMed
CA1178205 COSM424211 rs144272399	264	R>*	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1364058193 CA342987114	264	R>Q		No	ClinGen TOPMed
rs920387491 CA31219754	268	D>A		No	ClinGen TOPMed
CA1178207 rs769399031	268	D>N		No	ClinGen ExAC gnomAD
rs1347896354 CA342987150	270	V>A		No	ClinGen gnomAD
CA31219798 rs930404466	273	E>D		No	ClinGen TOPMed
rs774299268 CA1178211	276	G>V		No	ClinGen ExAC gnomAD
rs1320206921 CA342987189	277	L>V		No	ClinGen gnomAD
CA1178213 rs559158267	278	S>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777032434 CA1178214	278	S>C		No	ClinGen ExAC gnomAD
rs1316027050 CA342987202	279	C>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs200278882 CA31219874	280	R>Q		No	ClinGen 1000Genomes gnomAD
rs529047977 CA31219854	280	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1571067328 CA342987213	281	V>G		No	ClinGen Ensembl
CA342987208 rs1558045294	281	V>M		No	ClinGen Ensembl
rs1285313056 CA342987226	283	H>P		No	ClinGen gnomAD
CA1178217 rs143328267	284	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1178218 rs750404418	284	S>N		No	ClinGen ExAC gnomAD
CA1178219 rs772985800	287	E>K		No	ClinGen ExAC TOPMed gnomAD
rs766824137 CA1178220	288	G>S		No	ClinGen ExAC gnomAD
CA342987266 rs1295275943	289	Q>R		No	ClinGen TOPMed
TCGA novel	290	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1178221 rs140583445	291	I>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1178222 rs140583445	291	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1178223 rs375741058	292	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145809444 CA1178224	293	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs145809444 CA1178225	293	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA1178227 rs142766597	294	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1178228 rs142766597	294	Y>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA342987299 rs1333067532	295	W>R		No	ClinGen gnomAD
rs778952737 CA1178229	295	W>S		No	ClinGen ExAC gnomAD
CA1178253 rs749493376	297	G>R		No	ClinGen ExAC gnomAD
CA1178254 rs137976547	298	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA342987440 rs1571068667	299	Y>S		No	ClinGen Ensembl
CA342987450 rs972355579	300	T>N		No	ClinGen TOPMed
CA31220774 rs972355579	300	T>S		No	ClinGen TOPMed
TCGA novel	301	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1025315515 CA31220777	301	S>P		No	ClinGen Ensembl
rs760036601 CA1178256	302	M>I		No	ClinGen ExAC TOPMed gnomAD
CA1178255 rs774406527	302	M>T		No	ClinGen ExAC gnomAD
CA342987481 rs1264733068	304	L>M		No	ClinGen TOPMed gnomAD
rs1490039538 CA342987505	306	A>S		No	ClinGen gnomAD
rs767850265 CA1178257	306	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1178258 rs371189130	308	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1440071537 CA342987525	308	A>V		No	ClinGen TOPMed
rs760905720 CA1178259	309	V>I		No	ClinGen ExAC gnomAD
TCGA novel	310	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771849884 CA31220805	311	A>S		No	ClinGen Ensembl
rs764487486 CA1178260	311	A>V		No	ClinGen ExAC gnomAD
rs756955835 CA342987545	312	C>F		No	ClinGen ExAC gnomAD
CA1178262 rs756955835	312	C>S		No	ClinGen ExAC gnomAD
rs764844829 CA1178263	313	L>F		No	ClinGen ExAC gnomAD
rs543208774 CA1178264	316	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs543208774 CA31220849	316	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1015180156 CA31220867	317	L>F		No	ClinGen TOPMed gnomAD
rs1336157900 CA342987573	317	L>H		No	ClinGen gnomAD
CA342987581 rs1406758325	318	I>M		No	ClinGen TOPMed
CA1178266 rs779817716	318	I>T		No	ClinGen ExAC gnomAD
CA1178268 rs754781761	320	G>S		No	ClinGen ExAC gnomAD
CA1178269 rs140353863	322	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA31220900 rs140353863	322	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA342987610 rs1270990954	323	S>F		No	ClinGen TOPMed gnomAD
rs774424909 CA1178272	324	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs771070810 CA1178271	324	R>W		No	ClinGen ExAC TOPMed gnomAD
CA342987623 rs1185754587	326	K>E		No	ClinGen gnomAD
CA342987637 rs1384814626	328	Q>K		No	ClinGen gnomAD
CA342987641 rs1425402860	328	Q>R		No	ClinGen gnomAD
COSM3399837 rs772663580 CA1178274	329	T>I	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA342987693 rs1453004060	330	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs747537286 CA1178294	331	Y>C		No	ClinGen ExAC gnomAD
rs747537286 CA342987699	331	Y>S		No	ClinGen ExAC gnomAD
rs769149377 CA1178295	333	G>V		No	ClinGen ExAC gnomAD
rs777157013 CA342987725	334	V>F		No	ClinGen ExAC TOPMed gnomAD
rs777157013 COSM1601019 CA1178296	334	V>I	Variant assessed as Somatic; 0.0 impact. liver [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD

No associated diseases with P15813

3 regional properties for P15813

Type	Name	Position	InterPro Accession
domain	Immunoglobulin C1-set	219 - 289	IPR003597
domain	Immunoglobulin-like domain	185 - 292	IPR007110
domain	MHC class I-like antigen recognition-like	1 - 198	IPR011161

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein Basolateral cell membrane ; Single-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein Lysosome membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein	Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

12 GO annotations of cellular component

Name	Definition
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cell surface	The external part of the cell wall and/or plasma membrane.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
endosome membrane	The lipid bilayer surrounding an endosome.
external side of plasma membrane	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name	Definition
beta-2-microglobulin binding	Binding to beta-2-microglobulin.
cell adhesion molecule binding	Binding to a cell adhesion molecule.
endogenous lipid antigen binding	Binding to an endogenous cellular lipid antigen.
exogenous lipid antigen binding	Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids).
histone binding	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
lipid antigen binding	Binding to a lipid antigen.
lipopeptide binding	Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids.

9 GO annotations of biological process

Name	Definition
antigen processing and presentation, endogenous lipid antigen via MHC class Ib	The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
antigen processing and presentation, exogenous lipid antigen via MHC class Ib	The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
detection of bacterium	The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
heterotypic cell-cell adhesion	The attachment of a cell to a cell of a different type via adhesion molecules.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of innate immune response	Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
positive regulation of T cell mediated cytotoxicity	Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
positive regulation of T cell proliferation	Any process that activates or increases the rate or extent of T cell proliferation.
T cell selection	The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q4ACW4	CD1D	Antigen-presenting glycoprotein CD1d	Pan troglodytes (Chimpanzee)	PR
P29017	CD1C	T-cell surface glycoprotein CD1c	Homo sapiens (Human)	PR
Q9BZM4	ULBP3	UL16-binding protein 3	Homo sapiens (Human)	PR
P55899	FCGRT	IgG receptor FcRn large subunit p51	Homo sapiens (Human)	PR
Q63493	Cd1d	Antigen-presenting glycoprotein CD1d	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MGCLLFLLLW	ALLQAWGSAE	VPQRLFPLRC	LQISSFANSS	WTRTDGLAWL	GELQTHSWSN
70	80	90	100	110	120
DSDTVRSLKP	WSQGTFSDQQ	WETLQHIFRV	YRSSFTRDVK	EFAKMLRLSY	PLELQVSAGC
130	140	150	160	170	180
EVHPGNASNN	FFHVAFQGKD	ILSFQGTSWE	PTQEAPLWVN	LAIQVLNQDK	WTRETVQWLL
190	200	210	220	230	240
NGTCPQFVSG	LLESGKSELK	KQVKPKAWLS	RGPSPGPGRL	LLVCHVSGFY	PKPVWVKWMR
250	260	270	280	290	300
GEQEQQGTQP	GDILPNADET	WYLRATLDVV	AGEAAGLSCR	VKHSSLEGQD	IVLYWGGSYT
310	320	330
SMGLIALAVL	ACLLFLLIVG	FTSRFKRQTS	YQGVL