Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P15508
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P15508-F1 | Predicted | AlphaFoldDB |
No variants for P15508
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P15508 | |||||
No associated diseases with P15508
No regional properties for P15508
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P15508 | |||
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cortical actin cytoskeleton | The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. |
| cortical cytoskeleton | The portion of the cytoskeleton that lies just beneath the plasma membrane. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| spectrin | Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins. |
| spectrin-associated cytoskeleton | The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| ankyrin binding | Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| actin filament capping | The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. |
| hemopoiesis | The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. |
| plasma membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. |
| porphyrin-containing compound biosynthetic process | The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q01082 | SPTBN1 | Spectrin beta chain, non-erythrocytic 1 | Homo sapiens (Human) | PR |
| O15020 | SPTBN2 | Spectrin beta chain, non-erythrocytic 2 | Homo sapiens (Human) | PR |
| P11277 | SPTB | Spectrin beta chain, erythrocytic | Homo sapiens (Human) | PR |
| Q62261 | Sptbn1 | Spectrin beta chain, non-erythrocytic 1 | Mus musculus (Mouse) | PR |
| O88990 | Actn3 | Alpha-actinin-3 | Mus musculus (Mouse) | SS |
| Q7TPR4 | Actn1 | Alpha-actinin-1 | Mus musculus (Mouse) | SS |
| P57780 | Actn4 | Alpha-actinin-4 | Mus musculus (Mouse) | SS |
| Q9JI91 | Actn2 | Alpha-actinin-2 | Mus musculus (Mouse) | SS |
| Q9QWN8 | Sptbn2 | Spectrin beta chain, non-erythrocytic 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSATEFENV | GNQPPFSRIN | ARWDAPDDEL | DNDNSSARLF | ERSRIKALAD | EREVVQKKTF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TKWVNSHLAR | VSCRISDLYK | DLRDGRMLIK | LLEVLSGEML | PRPTKGKMRI | HCLENVDKAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QFLKEQRVHL | ENMGSHDIVD | GNHRLVLGLI | WTIILRFQIQ | DIVVQTQEGR | EQRSAKDALL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LWCQMKTAGY | PHVNVTNFTS | SWKDGLAFNA | LIHKHRPDLI | DFDKLKDSNA | RHNLEHAFDV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AERQLGIIPL | LDPEDVFTEN | PDEKSIITYV | VAFYHYFSKM | KVLAVEGKRV | GKVIDHAIET |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EKMIEKYSGL | ASDLLTWIEQ | TISVLNSRKF | ANSLSGVQQQ | LQAFSTYRTV | EKPPKFQEKG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLEVLLFTIQ | SRMRANNQKV | YTPHDGKLVS | DINRAWESLE | EAEYQRELAL | RSELIRQEFD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RKAAMRETWL | NENQRLVTQD | NFGYDLAAVE | AAKKKHEAIE | TDTAAYEERV | KALEDLAQEL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EKENYHDQKR | IIARKDNILR | LWSYLQELLR | SRRQRLEATL | ALQKLFQDML | HSIDWMDEIK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AHILSAEFGK | HLLEVEDLLQ | KHKLMEADIA | IQGDKVKAIT | AATLQFAEGK | GYQPCDPQVI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QDRVSHLEQC | FSELSNMAAG | RKAQLEQSKR | LWKFFWEMDE | AESWIKEKEQ | IYSSLDYGKD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LTSVLILQRK | HKAFEDELRG | LDAHLKQIFQ | EADDMVAQKQ | FGHPQIETRV | KEVSAQWDHL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KELAAFRKKD | LQDAENFFQF | QGDADDLKAW | LQDAHRLLSG | EDVGQDEGAT | RALGKKHKEF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LEELEESRGV | MEHLEHQAQG | FPEEFRDSPD | VTNRLQALRK | LYQQVLTQAE | LRGHKLQEAL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DLYTVFGESD | ACELWMTEKG | KWLDQMDIPN | TLEDLEVVQH | RFDILDQEMK | TLMAQIDGVN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LAANNLVESG | HPRSGEVKQY | QDRLNKRWQA | FQAVVSEQRE | AVDSALRVNN | YCVDCEETSK |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| WIMDKTKVVE | STKDLGQDLA | GVIAIQRKLS | GLERDVLAIR | DRVSALERES | QYLMESHPEQ |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KEDIGQRQAD | VEKLWKGLQD | ALQGQELSLG | EASKLQAFLQ | DLDDFKAWLS | MAQKAVASED |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| MPESLPEAEQ | LLQQHAAIKE | EIDAHRDDYH | RVKASGEKVI | EGQTDPDYQL | LGQRLEGLDT |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| DWDALRRMWE | SRGNTLTQCL | GFQEFQKDAK | QAEAILSNQE | YTLAHLEPPD | SLAAAEAGIR |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| KFEDFLVSME | NNRDKILSPV | DSGNKLVAEG | NLYSNKIMEK | VQLIEDRHKK | NNEKAQEATV |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| LLKDNLELQN | FLQNCKELTL | WINDKLLTSP | DVSYDEARNL | HNKWMKHQAF | MAELASHQGW |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| LENIDAEGRQ | LMAEKPQFKD | VVSERLEALH | KLWEELQSTA | KAKAEQLSAA | RSSDLRLQTH |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| ADLNKWIGAM | EDQLRSDDLG | KDLTTVNRML | AKLKRVEEQV | NLRKEELEEL | FADAPSLGAE |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| AGDTDMSIEK | RFLDLLEPLG | RRKKQLELSK | AKLQISRDLE | DETLWVEERL | PLAQSADYGT |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| NLQTVQLFMK | KNQTLQNEIL | GHAPRVEDVL | RRGQELVKAA | EIDCQDIEER | LGHLQSSWDT |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| LREAAAGRLQ | RLRDAHEAQQ | YYLDAGEAEA | WISEQELYVF | SDEPPKDEEG | AIVMLKRHLR |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| QQRTVEEYGR | NIKQLAGRAQ | SLLSAGHPEG | EQIIRLQGQV | DKQYAGLKDM | AEERRRRLEN |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| MYHLFQLKRE | ADDLEQWITE | KEMVASSQEM | GQDFDHVTML | RDKFRDFARE | TGAIGQERVD |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| NVTIIERLID | AGHSEAATIA | EWKDGLNDMW | ADLLELIDTR | MQLLAASYDL | HRYFYTGTEI |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| LGLIDEKHRE | LPEDVGLDAS | TAESFHRVHT | AFERELHLLG | VQVQQFQDVA | TRLQTAYAGE |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| KADAIQSKEQ | EVSAAWQALL | DACAGRRAQL | VDTADKFRFF | SMVRDLLSWM | ESIIRQIETQ |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| ERPRDVSSVE | LLLKYHQGIK | AEINTRAKNF | STCLELGESL | LQRQHQASDE | IREKLQQVIS |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| RRQEMNDKWE | ARSDRLHMLL | EVCQFSRDAS | VAEAWLIAQE | PYLASRDFGH | TVDSVEKLIK |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| RHEAFEKSTA | SWAERFAALE | KPTTLELKER | QTPERPTEEP | GPQEEEGETA | GEAPQVHHAA |
| 2110 | 2120 | ||||
| TERTSPVSFM | SRLSSSWESL | LPEPAHPF |