AiPD: Autoinhibited Protein Database

P15498

EV SS

Gene name	VAV1 (VAV)
Protein name	Proto-oncogene vav
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7409
EC number
Protein Class	PROTEIN VAV (PTHR45818)

Descriptions

The Vav family is a group of tyrosine phosphorylation-dependent guanine nucleotide exchange factors (GEFs) that activate members of the Rac and Rho families of guanosine triphosphatases (GTPases) downstream of protein tyrosine kinases. When the tyrosine residues within the AC region are non-phosphorylated, the CH domain and Ac region occlude the GTPase-binding site within DH domain. The interaction is stabilized by the interaction between the hydroxyl group of Tyr174 within Ac region and GTPase binding site as well as the interaction between CH domain and DH-PH domains. The Y174F mutant displays constitutive and phosphorylation-independent catalytic activity.

Autoinhibitory domains (AIDs)

Target domain	194-373 (DH domain)
Relief mechanism	PTM
Assay	Deletion assay, Structural analysis, Mutagenesis experiment

AID

1-134 (CH domain)

Target domain

194-373 (DH domain)

Relief mechanism

PTM (Phosphorylation of Tyr174)

Assay

Deletion assay, Structural analysis, Mutagenesis experiment

Target domain	194-373 (DH domain)
Relief mechanism	PTM
Assay	Mutagenesis experiment, Deletion assay, Structural analysis

AID

167-178 (a helix in N-terminal acidic region)

Target domain

194-373 (DH domain)

Relief mechanism

PTM (Phosphorylation of Tyr174 by receptor stimulation via Src- and Syk-family kinases)

Assay

Mutagenesis experiment, Deletion assay, Structural analysis

782-842 (C-terminal SH3 domain) SS

Target domain	194-373 (DH domain)
Relief mechanism	Partner binding, PTM
Assay	, Structural analysis

AID

782-842 (C-terminal SH3 domain)

Target domain

194-373 (DH domain)

Relief mechanism

Partner binding (Putative mechanism, binding of PRR-containing proteins to C-terminal SH3 domain), PTM (Lck-mediated phosphorylation)

Assay

, Structural analysis

Accessory elements

No accessory elements

References

Barreira M et al. (2014) "The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins", Science signaling, 7, ra35

Rapley J et al. (2008) "Crucial structural role for the PH and C1 domains of the Vav1 exchange factor", EMBO reports, 9, 655-61

Yu B et al. (2010) "Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1", Cell, 140, 246-56

Aghazadeh B et al. (2000) "Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation", Cell, 102, 625-33

Autoinhibited structure

Activated structure

10 structures for P15498

Entry ID	Method	Resolution	Chain	Position	Source
2CRH	NMR	-	A	629-775	PDB
2LCT	NMR	-	A	664-767	PDB
2MC1	NMR	-	A	664-767	PDB
2ROR	NMR	-	A	629-775	PDB
3BJI	X-ray	260 A	A/B	189-565	PDB
3KY9	X-ray	273 A	A/B	2-584	PDB
6NEW	X-ray	250 A	A	170-575	PDB
6NF1	X-ray	260 A	A	2-575	PDB
6NFA	X-ray	270 A	A	170-575	PDB
AF-P15498-F1	Predicted				AlphaFoldDB

460 variants for P15498

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1358155015 CA403647520	2	E>*		No	ClinGen gnomAD
rs944033950 CA304812496	5	R>H		No	ClinGen TOPMed gnomAD
rs1489564674 CA403647629	8	T>S		No	ClinGen gnomAD
rs1599606651 CA403647641	9	H>P		No	ClinGen Ensembl
CA304812510 rs977000607	9	H>Q		No	ClinGen Ensembl
CA9132092 rs777064585	13	Q>R		No	ClinGen ExAC gnomAD
CA9132094 rs373948131	15	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA304812536 rs1054377673	18	P>S		No	ClinGen TOPMed
rs1599606734 CA403647880	24	T>S		No	ClinGen Ensembl
rs1191997621 CA403647898	26	D>N		No	ClinGen TOPMed
rs947824219 CA304812558	27	G>A		No	ClinGen TOPMed
CA403647986 rs1195928000	31	C>S		No	ClinGen TOPMed
CA9132102 rs753758099	36	A>T		No	ClinGen ExAC gnomAD
CA403648109 rs1568276930	38	R>Q		No	ClinGen Ensembl
CA403648105 rs1310819086	38	R>W		No	ClinGen gnomAD
CA403648186 rs1209276397	45	Q>H		No	ClinGen TOPMed
CA403648247 rs1371201347	49	N>S		No	ClinGen gnomAD
CA403648246 rs1371201347	49	N>T		No	ClinGen gnomAD
rs768101725 CA9132109	53	H>R		No	ClinGen ExAC TOPMed gnomAD
rs199610931 CA403648402	57	L>M		No	ClinGen 1000Genomes TOPMed gnomAD
CA403648411 rs1240166735	57	L>P		No	ClinGen gnomAD
rs199610931 CA304812632	57	L>V		No	ClinGen 1000Genomes TOPMed gnomAD
CA9132113 COSM1158111 COSM3389498 rs773638542	58	R>C	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA403648413 rs773638542	58	R>G		No	ClinGen ExAC gnomAD
CA403648421 rs1405739568	58	R>H		No	ClinGen gnomAD
rs1340543052 CA403648527	62	L>P		No	ClinGen TOPMed
rs1176906044 CA403648534	63	R>C		No	ClinGen TOPMed gnomAD
COSM294943 CA9132115 rs771269172	63	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs759771157 CA9132117	68	Q>P		No	ClinGen ExAC gnomAD
rs1022061335 CA304798306	72	L>H		No	ClinGen TOPMed
rs1599653395 CA403613336	77	T>A		No	ClinGen Ensembl
rs768905072 CA9132156	80	S>Y		No	ClinGen ExAC gnomAD
CA9132157 rs776870760	81	T>A		No	ClinGen ExAC gnomAD
rs1349630957 CA403613525	87	G>S		No	ClinGen gnomAD
CA403613564 rs1181866661	89	K>R		No	ClinGen gnomAD
CA9132162 rs767189353	90	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9132161 rs774093642	90	R>W		No	ClinGen ExAC TOPMed gnomAD
CA403613603 rs370716087	91	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA403613612 rs1182441679 COSM1003061	92	E>K	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1182441679 CA403613615	92	E>Q		No	ClinGen TOPMed gnomAD
CA9132165 rs763699001	95	E>G		No	ClinGen ExAC gnomAD
CA403613687 rs1176543639	96	A>T		No	ClinGen TOPMed
CA403613792 rs1453438674	101	D>N		No	ClinGen TOPMed gnomAD
CA403614553 rs1599654248	108	V>G		No	ClinGen Ensembl
rs1389661073 CA403614573	109	I>T		No	ClinGen gnomAD
rs750986727 CA9132186	110	Y>C		No	ClinGen ExAC gnomAD
CA9132187 rs750986727	110	Y>F		No	ClinGen ExAC gnomAD
CA9132185 rs764621143	110	Y>H		No	ClinGen ExAC gnomAD
rs780665383 CA9132188	111	T>A		No	ClinGen ExAC gnomAD
CA9132190 rs755333060	114	A>V		No	ClinGen ExAC gnomAD
CA403614750 rs1599654300	118	T>S		No	ClinGen Ensembl
rs1199160941 CA403614833	122	Q>R		No	ClinGen gnomAD
rs772003183 CA9132196	126	I>T		No	ClinGen ExAC gnomAD
rs776311282 CA9132217	131	T>N		No	ClinGen ExAC gnomAD
rs1360777593 CA403615085	132	E>K		No	ClinGen gnomAD
rs1360777593 CA403615081	132	E>Q		No	ClinGen gnomAD
CA403615090 rs1317626209	132	E>V		No	ClinGen TOPMed
CA403615111 rs1245951846	134	E>A		No	ClinGen TOPMed gnomAD
CA403615124 rs1433417325	135	S>N		No	ClinGen TOPMed
rs769333944 CA9132219	142	Y>H		No	ClinGen ExAC gnomAD
CA403615252 rs1402302197	143	S>I		No	ClinGen gnomAD
CA403615272 rs1599654536	144	G>D		No	ClinGen Ensembl
rs1319067024 CA403615305	147	D>N		No	ClinGen TOPMed gnomAD
rs772860004 CA9132220	148	Q>L		No	ClinGen ExAC gnomAD
CA403615467 rs776054554	150	D>E		No	ClinGen ExAC TOPMed gnomAD
CA403615363 rs1228580781	150	D>N		No	ClinGen TOPMed gnomAD
CA403615472 rs1275275449	151	D>N		No	ClinGen gnomAD
rs761012404 CA9132244	152	T>K		No	ClinGen ExAC TOPMed gnomAD
CA403615494 rs761012404	152	T>M		No	ClinGen ExAC TOPMed gnomAD
CA403615503 rs1490765788	153	V>A		No	ClinGen TOPMed gnomAD
CA403615495 rs1249568957	153	V>M		No	ClinGen gnomAD
rs1199900607 CA403615517	154	E>A		No	ClinGen gnomAD
CA9132245 rs764489679	154	E>D		No	ClinGen ExAC gnomAD
rs141064710 CA9132247	156	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA9132248 rs765401527 RCV000756895	158	D>N		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA403615637 rs1408891434	160	Y>C		No	ClinGen gnomAD
rs1405584178 CA403615656	161	D>E		No	ClinGen TOPMed
rs1369256102 CA403615679	163	V>M		No	ClinGen TOPMed gnomAD
rs1304200162 CA403615713	166	E>K		No	ClinGen gnomAD
CA403615735 rs1345103912	167	E>G		No	ClinGen gnomAD
COSM3783301 CA9132249 COSM3783302 rs186483354	168	A>V	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs781046322 CA403615763	170	G>D		No	ClinGen ExAC gnomAD
rs781046322 CA9132251	170	G>V		No	ClinGen ExAC gnomAD
CA9132254 rs368628133	172	E>K		No	ClinGen ESP ExAC gnomAD
rs138608402 CA9132255	173	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs753902811 CA9132257	176	D>H		No	ClinGen ExAC TOPMed gnomAD
rs745430064 CA403615863	179	R>C		No	ClinGen ExAC TOPMed gnomAD
CA403615865 rs1166175893	179	R>H		No	ClinGen gnomAD
CA9132258 rs745430064	179	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1005492261 CA304803120	182	P>L		No	ClinGen Ensembl
CA403615896 rs1164581766	182	P>S		No	ClinGen gnomAD
CA403615908 rs1320481232	183	V>A		No	ClinGen gnomAD
rs145204838 CA304803125	183	V>M		No	ClinGen ESP TOPMed gnomAD
rs1309396077 CA403615913	184	S>Y		No	ClinGen gnomAD
CA403615921 rs1327263668	185	M>L		No	ClinGen gnomAD
rs1364790745 CA403616024	188	K>R		No	ClinGen gnomAD
rs1289664598 CA403616034	189	M>L		No	ClinGen TOPMed
rs1472371108 CA403616061	190	T>A		No	ClinGen gnomAD
CA403616098 rs1157170873	192	Y>S		No	ClinGen TOPMed gnomAD
CA403616161 rs1568303959	195	R>C		No	ClinGen Ensembl
rs367965223 CA9132280	195	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA403616164 rs367965223	195	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9132281 rs200332893	196	C>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs866988780 CA304803300	200	R>L		No	ClinGen TOPMed gnomAD
rs866988780 CA403616261	200	R>Q		No	ClinGen TOPMed gnomAD
CA304803293 rs868133137	200	R>W		No	ClinGen gnomAD
rs1284743157 CA403616323	203	Q>*		No	ClinGen gnomAD
rs1323816967 CA403616346	204	Q>*		No	ClinGen gnomAD
CA304803302 rs867655128	205	T>K		No	ClinGen gnomAD
CA403616370 rs867655128	205	T>M		No	ClinGen gnomAD
rs1198128245 CA403616378	206	E>G		No	ClinGen gnomAD
rs1482551725 CA403616375	206	E>K		No	ClinGen gnomAD
rs1251894078 CA403616386	207	E>K		No	ClinGen gnomAD
CA304803328 rs774816667	209	Y>*		No	ClinGen Ensembl
rs1299101805 CA403616422	210	T>A		No	ClinGen TOPMed
CA403616426 rs1180494357	210	T>N		No	ClinGen gnomAD
CA403616432 rs1480926472	211	D>Y		No	ClinGen gnomAD
CA403616467 rs1268445203	214	G>D		No	ClinGen TOPMed gnomAD
CA403616470 rs1268445203	214	G>V		No	ClinGen TOPMed gnomAD
rs1369879958 CA403616500	217	Q>H		No	ClinGen gnomAD
CA9132286 rs763208696	217	Q>K		No	ClinGen ExAC gnomAD
CA9132287 RCV000660644 rs201002344	217	Q>R		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA403617341 rs1346594776	222	K>E		No	ClinGen gnomAD
COSM1003065 rs759730093 CA403617443	226	R>L	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs759730093 CA9132306	226	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9132305 rs774426463	226	R>W		No	ClinGen ExAC gnomAD
rs1311112182 CA403617636	233	I>T		No	ClinGen gnomAD
CA403617624 rs1228093524	233	I>V		No	ClinGen gnomAD
CA9132309 rs184362178	235	I>N		No	ClinGen 1000Genomes ExAC
CA9132310 rs368374146	240	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA9132311 rs750236444	241	E>K		No	ClinGen ExAC gnomAD
rs1490731461 CA403618561	245	R>C		No	ClinGen gnomAD
rs375421504 CA304806528	245	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs375421504 CA9132339	245	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1057439002 CA304806532	246	V>F		No	ClinGen Ensembl
rs1476715930 CA403618602	248	T>I		No	ClinGen gnomAD
rs772426650 CA9132342	249	H>N		No	ClinGen ExAC TOPMed gnomAD
rs772426650 CA403618608	249	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1407473033 CA403618698	254	M>I		No	ClinGen gnomAD
rs747143456 CA9132344	254	M>T		No	ClinGen ExAC gnomAD
rs768614314 CA9132345	259	G>S		No	ClinGen ExAC gnomAD
rs1330758751 CA403618737	259	G>V		No	ClinGen gnomAD
CA9132346 rs773238903	260	T>I		No	ClinGen ExAC gnomAD
rs1599658787 CA403618738	260	T>P		No	ClinGen Ensembl
rs749155012 CA9132347	261	P>R		No	ClinGen ExAC gnomAD
rs930218281 CA304806550	262	G>C		No	ClinGen TOPMed
rs537876361 CA9132350	263	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1003067 rs537876361 CA9132349	263	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs757852816 CA9132351	265	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1288629849 CA403618792	269	V>I		No	ClinGen TOPMed gnomAD
rs763490760 CA9132354	270	F>L		No	ClinGen ExAC gnomAD
CA9132355 rs753340238	271	I>M		No	ClinGen ExAC gnomAD
CA403618835 rs1248163658	275	E>K		No	ClinGen TOPMed gnomAD
rs1161591039 CA403618861	276	R>S		No	ClinGen gnomAD
rs117819421 RCV000507235 CA9132366	279	V>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA9132369 rs771827278	282	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9132370 rs775175030	282	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1230009851 CA403618928	286	Q>R		No	ClinGen gnomAD
CA304807839 rs1029661692	289	S>L		No	ClinGen Ensembl
CA304807869 rs868785597	290	A>V		No	ClinGen Ensembl
CA403618956 rs1328125015	291	S>G		No	ClinGen gnomAD
rs866683359 CA304807879	291	S>N		No	ClinGen Ensembl
rs995029550 CA304807884	291	S>R		No	ClinGen TOPMed gnomAD
CA304807894 rs868853012	294	L>M		No	ClinGen gnomAD
rs1201478572 CA403618985	295	D>G		No	ClinGen gnomAD
rs866015643 CA403618990	296	R>C		No	ClinGen TOPMed
rs375777917 CA9132372	296	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs866015643 CA304807908	296	R>S		No	ClinGen TOPMed
CA304807915 rs886702218	298	A>T		No	ClinGen TOPMed gnomAD
rs868159906 CA304807916	298	A>V		No	ClinGen gnomAD
rs865782015 CA304807919	299	A>T		No	ClinGen gnomAD
CA304807924 rs868005702	300	A>D		No	ClinGen Ensembl
rs868298108 CA304807930	301	R>Q		No	ClinGen TOPMed gnomAD
rs1466647685 CA403619014	301	R>W		No	ClinGen gnomAD
CA9132377 rs758873754	304	V>M		No	ClinGen ExAC TOPMed gnomAD
CA9132378 rs561810781	305	Q>K		No	ClinGen 1000Genomes ExAC gnomAD
CA403620018 rs1447375449	312	S>Y		No	ClinGen gnomAD
rs759883753 CA9132399	313	Q>E		No	ClinGen ExAC gnomAD
rs1291265584 CA403620168	318	G>R		No	ClinGen TOPMed gnomAD
rs1291265584 CA403620164	318	G>R		No	ClinGen TOPMed gnomAD
rs141278487 CA304809143	320	F>L		No	ClinGen ESP gnomAD
CA304809151 rs865777450	321	T>I		No	ClinGen Ensembl
rs1599661363 CA403620255	321	T>P		No	ClinGen Ensembl
rs1287285533 CA403620299	323	R>Q		No	ClinGen TOPMed
rs1009235778 CA304809162	323	R>W		No	ClinGen gnomAD
CA403620340 rs1599661396	324	D>A		No	ClinGen Ensembl
rs753876214 CA9132404	324	D>E		No	ClinGen ExAC gnomAD
CA9132405 rs147266875	329	P>L		No	ClinGen ESP ExAC gnomAD
CA403620482 rs1379584911	331	Q>R		No	ClinGen TOPMed
rs779910201 CA9132406	333	V>I		No	ClinGen ExAC TOPMed gnomAD
CA9132429 rs755829677	344	V>G		No	ClinGen ExAC gnomAD
CA403620947 rs1178788797	344	V>L		No	ClinGen TOPMed gnomAD
CA403620950 rs1178788797	344	V>L		No	ClinGen TOPMed gnomAD
CA403620945 rs1178788797	344	V>M		No	ClinGen TOPMed gnomAD
rs777506541 CA9132430	345	K>N		No	ClinGen ExAC gnomAD
CA403620988 rs1480476651	346	H>Q		No	ClinGen TOPMed
rs1599661746 CA403620983	346	H>Y		No	ClinGen Ensembl
rs374026712 CA9132433	350	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1410716733 CA403621102	351	M>L		No	ClinGen gnomAD
CA403621106 rs1287984953	351	M>T		No	ClinGen gnomAD
rs746412253 CA9132434	353	K>E		No	ClinGen ExAC gnomAD
rs1485237675 CA403621170	353	K>N		No	ClinGen TOPMed
rs1485237675 CA403621167	353	K>N		No	ClinGen TOPMed
CA9132435 rs528297651	355	N>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1599661792 CA403621205	355	N>T		No	ClinGen Ensembl
CA9132438 rs764359782	356	L>Q		No	ClinGen ExAC gnomAD
CA403621218 rs760972545	356	L>V		No	ClinGen ExAC TOPMed gnomAD
CA9132439 rs776828202	358	L>M		No	ClinGen ExAC TOPMed gnomAD
rs761920796 CA9132440	359	A>S		No	ClinGen ExAC gnomAD
rs1204298722 CA403621308	360	L>Q		No	ClinGen TOPMed
rs1324332080 CA403621393	363	M>L		No	ClinGen TOPMed
rs1351334791 CA403621441	364	R>K		No	ClinGen TOPMed gnomAD
CA9132465 rs752674851	381	R>L		No	ClinGen ExAC gnomAD
CA304809693 rs958499128	392	N>K		No	ClinGen TOPMed
rs1599662242 CA403622527	395	Q>R		No	ClinGen Ensembl
rs765008044 CA9132489	398	A>P		No	ClinGen ExAC gnomAD
CA403622757 rs1453178980	405	I>M		No	ClinGen TOPMed gnomAD
rs1568307502 CA403622849	408	E>Q		No	ClinGen Ensembl
rs1156670926 CA403622855	408	E>V		No	ClinGen gnomAD
CA403622956 rs1312096452	413	S>L		No	ClinGen gnomAD
rs779560365 CA9132492	415	E>D		No	ClinGen ExAC gnomAD
CA403623012 rs751028226	416	R>P		No	ClinGen ExAC gnomAD
CA9132493 rs751028226	416	R>Q		No	ClinGen ExAC gnomAD
rs755481100 CA9132494	420	M>I		No	ClinGen ExAC gnomAD
rs1330825202 CA403623069	420	M>V		No	ClinGen TOPMed gnomAD
rs1269495767 CA403624055	425	F>L		No	ClinGen gnomAD
rs1016602018 CA304810393	432	L>F		No	ClinGen TOPMed
rs768075621 CA9132513	433	I>L		No	ClinGen ExAC gnomAD
rs768075621 CA403624209	433	I>V		No	ClinGen ExAC gnomAD
rs1367078790 CA403624390	441	Y>C		No	ClinGen TOPMed
rs756598154 CA9132516	442	D>E		No	ClinGen ExAC gnomAD
CA9132517 rs749604125	444	K>R		No	ClinGen ExAC gnomAD
CA403624475 rs1294945264	445	D>E		No	ClinGen gnomAD
CA403624527 rs1390770795	448	N>S		No	ClinGen gnomAD
rs1231065156 CA403624564	450	H>R		No	ClinGen gnomAD
CA9132518 rs757570479	450	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1307308032 CA403624618	453	Q>L		No	ClinGen gnomAD
CA9132520 rs746012151	454	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1213212291 CA631671664	460	G>*		No	ClinGen gnomAD
rs1160296531 CA403624716	461	D>Y		No	ClinGen TOPMed
rs1251062530 CA403624733	462	R>Q		No	ClinGen gnomAD
CA9132522 rs377393342	464	N>S		No	ClinGen ESP ExAC gnomAD
CA9132548 rs774877233	468	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1414342417 CA403625716	469	H>Y		No	ClinGen gnomAD
CA9132550 rs764580249	470	M>T		No	ClinGen ExAC
CA9132549 rs760219042	470	M>V		No	ClinGen ExAC gnomAD
CA9132551 rs754343672	471	F>L		No	ClinGen ExAC gnomAD
rs754343672 CA403625784	471	F>L		No	ClinGen ExAC gnomAD
CA9132553 COSM1397450 rs144739934	475	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs144739934 CA403625834	475	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1315125144 CA403625912	476	D>G		No	ClinGen gnomAD
CA403625944 rs1280838792	477	Q>H		No	ClinGen gnomAD
rs1181183503 CA403626023	480	Q>H		No	ClinGen TOPMed
rs113853914 CA304812524	481	G>A		No	ClinGen Ensembl
CA9132555 rs758695911	481	G>S		No	ClinGen ExAC gnomAD
rs1253541466 CA403626182	486	F>I		No	ClinGen gnomAD
CA403626291 rs1297726249	490	E>Q		No	ClinGen gnomAD
rs1376401683 CA403626501	497	E>G		No	ClinGen gnomAD
CA403626489 rs1176105969	497	E>Q		No	ClinGen gnomAD
CA403626628 rs1242168799	501	M>K		No	ClinGen TOPMed gnomAD
rs1242168799 CA403626634	501	M>R		No	ClinGen TOPMed gnomAD
CA9132619 rs373199416	507	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs769393831 CA9132620	508	P>L		No	ClinGen ExAC gnomAD
CA304813957 rs983328600	510	N>S		No	ClinGen gnomAD
CA9132623 rs150058721	513	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs199798227 CA9132627	514	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403627434 rs199798227	514	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9132625 rs759808290	514	N>S		No	ClinGen ExAC TOPMed gnomAD
rs764184305 CA9132629	515	G>E		No	ClinGen ExAC TOPMed gnomAD
CA9132628 rs760796877	515	G>R		No	ClinGen ExAC TOPMed gnomAD
rs911990552 CA304814034	516	H>R		No	ClinGen TOPMed
CA403627598 rs1240545578	522	S>C		No	ClinGen gnomAD
rs758364316 CA9132631	525	E>A		No	ClinGen ExAC gnomAD
rs1384346863 CA403627637	525	E>K		No	ClinGen TOPMed
CA403627671 rs1188954936	527	T>A		No	ClinGen gnomAD
CA9132661 rs61750003	539	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403628673 rs61750003	539	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9132662 rs747319718	539	T>S		No	ClinGen ExAC gnomAD
rs776710563 CA9132664	545	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1172825998 CA403628821	545	R>H		No	ClinGen TOPMed gnomAD
CA9132665 rs761989004	547	H>P		No	ClinGen ExAC gnomAD
rs761989004 CA403628877	547	H>R		No	ClinGen ExAC gnomAD
rs773293298 CA9132667	548	R>Q		No	ClinGen ExAC gnomAD
rs527259397 CA9132666	548	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1389196157 CA403628958	550	R>Q		No	ClinGen TOPMed gnomAD
CA9132668 rs759577156	550	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1373911353 CA403629067	555	K>R		No	ClinGen gnomAD
CA304814317 rs867833957	556	E>K		No	ClinGen Ensembl
rs752552285 CA9132670	559	G>V		No	ClinGen ExAC gnomAD
rs1229831976 CA403629279	561	V>F		No	ClinGen gnomAD
rs1599667596 CA403629286	561	V>G		No	ClinGen Ensembl
CA403629272 rs1229831976	561	V>I		No	ClinGen gnomAD
CA9132672 rs763849108	562	P>L		No	ClinGen ExAC gnomAD
CA403629335 rs1568310526	563	P>S		No	ClinGen Ensembl
CA9132675 rs778321882	565	G>S		No	ClinGen ExAC gnomAD
COSM3836110 CA304814344 COSM3836111 rs912574175	566	R>*	breast [Cosmic]	No	ClinGen cosmic curated Ensembl
CA403629430 rs749873161	566	R>P		No	ClinGen ExAC TOPMed gnomAD
COSM440606 CA9132676 rs749873161	566	R>Q	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA403629471 rs1280760668	567	H>R		No	ClinGen TOPMed
CA403629514 rs1250867780	569	Q>*		No	ClinGen gnomAD
CA9132700 rs756302359	570	D>V		No	ClinGen ExAC gnomAD
CA304814501 rs867250812	572	P>L		No	ClinGen Ensembl
rs771115216 CA9132703	575	M>L		No	ClinGen ExAC gnomAD
CA403629778 rs771115216	575	M>V		No	ClinGen ExAC gnomAD
CA9132726 rs146852359	581	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9132725 rs747930438	581	H>Y		No	ClinGen ExAC gnomAD
COSM267744 rs1280592299 CA403629994	582	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA9132727 rs140267055	582	R>H		No	ClinGen ESP ExAC gnomAD
CA403630039 rs1052570396	585	Q>H		No	ClinGen TOPMed gnomAD
CA304814618 rs936943603	588	K>R		No	ClinGen Ensembl
CA9132728 rs762621714	589	R>S		No	ClinGen ExAC TOPMed gnomAD
CA9132729 COSM1751240 rs571091777	591	E>K	urinary_tract [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA403630160 rs1380290504	592	L>M		No	ClinGen gnomAD
rs774824315 CA9132750	593	G>D		No	ClinGen ExAC gnomAD
rs1438223396 CA403630169	593	G>R		No	ClinGen gnomAD
rs145348573 CA304815975	594	L>P		No	ClinGen ESP
CA403631318 rs1160716963	604	Y>F		No	ClinGen TOPMed
CA9132755 rs754314420	605	G>R		No	ClinGen ExAC TOPMed gnomAD
CA9132754 rs754314420	605	G>R		No	ClinGen ExAC TOPMed gnomAD
rs888309098 CA304816022	609	P>A		No	ClinGen gnomAD
CA304816024 rs796871083	609	P>L		No	ClinGen TOPMed gnomAD
rs888309098 CA304816020	609	P>T		No	ClinGen gnomAD
rs765599789 CA9132756	610	P>A		No	ClinGen ExAC gnomAD
CA403631500 rs1255542793	611	G>R		No	ClinGen TOPMed gnomAD
rs750632166 CA304816036	613	I>N		No	ClinGen ExAC TOPMed gnomAD
rs750632166 CA9132757	613	I>T		No	ClinGen ExAC TOPMed gnomAD
rs758497118 CA9132758	615	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1444964059 CA403631572	615	P>S		No	ClinGen TOPMed
CA9132761 rs771801566	618	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM130144 rs751523777 CA9132760	618	R>W	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA304816054 rs1030346858	620	N>S		No	ClinGen Ensembl
CA403631695 rs1432765301	621	P>L		No	ClinGen gnomAD
CA9132763 rs749148436	621	P>S		No	ClinGen ExAC gnomAD
rs1347441521 CA403631739	623	D>V		No	ClinGen TOPMed
CA9132765 rs778524498	624	I>T		No	ClinGen ExAC gnomAD
CA9132764 rs757014068	624	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1476236857 CA403631779	626	E>Q		No	ClinGen gnomAD
rs1165549029 CA403631812	628	T>A		No	ClinGen gnomAD
rs745565957 CA9132766	628	T>M		No	ClinGen ExAC gnomAD
rs745565957 CA304816067	628	T>R		No	ClinGen ExAC gnomAD
rs775081040 CA9132768	631	E>D		No	ClinGen ExAC gnomAD
rs989103478 CA304816069	631	E>K		No	ClinGen Ensembl
rs1320553543 CA403631884	631	E>V		No	ClinGen TOPMed
rs1345595140 CA403631906	632	A>V		No	ClinGen gnomAD
CA304816074 rs914814433	633	E>G		No	ClinGen Ensembl
rs1401587091 CA403631952	634	Q>H		No	ClinGen TOPMed
CA403632209 rs1239964889	640	R>K		No	ClinGen TOPMed gnomAD
CA9132783 rs372781321	643	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA9132784 rs758131236	644	T>I		No	ClinGen ExAC TOPMed gnomAD
CA403632321 rs1255512643	647	I>T		No	ClinGen gnomAD
rs1599670875 CA403632363	650	F>V		No	ClinGen Ensembl
CA403632415 rs1440772258	653	N>K		No	ClinGen gnomAD
rs1365619938 CA403632418	654	R>G		No	ClinGen TOPMed
rs1599670900 CA403632449	655	V>G		No	ClinGen Ensembl
rs1183825805 CA403632431	655	V>M		No	ClinGen gnomAD
rs1438844911 CA403632483	657	P>H		No	ClinGen gnomAD
CA403632498 rs1021382052	658	Y>C		No	ClinGen TOPMed
rs1021382052 CA304816391	658	Y>F		No	ClinGen TOPMed
CA403632506 rs1466577593	659	V>I		No	ClinGen TOPMed
CA304822549 rs770645311	662	P>R		No	ClinGen Ensembl
CA403634504 rs1177495695	662	P>T		No	ClinGen TOPMed
CA9132804 rs779809203	663	P>L		No	ClinGen ExAC gnomAD
CA304822552 rs779809203	663	P>R		No	ClinGen ExAC gnomAD
rs751283015 CA9132805	666	L>V		No	ClinGen ExAC TOPMed gnomAD
rs747601332 CA9132808	667	S>C		No	ClinGen ExAC TOPMed gnomAD
CA403635108 rs1310385802	671	W>*		No	ClinGen TOPMed
CA403635120 rs150162861	673	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs150162861 CA9132831	673	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA403635123 rs1295017027	673	A>V		No	ClinGen gnomAD
rs370586875 CA9132833	675	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1486725623 CA403635140	676	M>T		No	ClinGen gnomAD
rs760861518 CA9132834	678	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9132835 rs768643429	679	A>V		No	ClinGen ExAC gnomAD
rs374124624 CA9132836	680	G>E		No	ClinGen ESP ExAC gnomAD
rs1329754782 CA403635176	682	E>G		No	ClinGen Ensembl
CA403635189 rs1189499025	684	I>V		No	ClinGen TOPMed gnomAD
CA304824401 rs868734448	686	A>T		No	ClinGen Ensembl
rs1182028191 CA403635209	687	N>S		No	ClinGen gnomAD
rs41306365 CA9132837	688	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA403635217 rs1424857566	688	R>H		No	ClinGen gnomAD
CA304824405 rs912827901	690	D>G		No	ClinGen TOPMed
rs759398960 CA9132840	691	G>R		No	ClinGen ExAC TOPMed gnomAD
CA403635257 rs1360174946	695	V>M		No	ClinGen gnomAD
rs1158113451 CA403635266	696	R>Q		No	ClinGen gnomAD
rs1398201999 CA403635264	696	R>W		No	ClinGen gnomAD
rs1599680819 CA403635289	699	V>G		No	ClinGen Ensembl
rs1395314402 CA403635286	699	V>L		No	ClinGen gnomAD
rs1395314402 CA403635284	699	V>M		No	ClinGen gnomAD
rs753331935 CA9132845	707	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1030859905 CA304824417	708	S>N		No	ClinGen Ensembl
rs1568319246 CA403635794	711	Y>N		No	ClinGen Ensembl
CA9132874 rs769969950	712	N>K		No	ClinGen ExAC TOPMed gnomAD
CA403635823 rs769969950	712	N>K		No	ClinGen ExAC TOPMed gnomAD
CA403635830 rs745830320	713	V>F		No	ClinGen ExAC TOPMed gnomAD
rs745830320 CA9132875	713	V>I		No	ClinGen ExAC TOPMed gnomAD
rs775206603 CA9132878	715	V>F		No	ClinGen ExAC gnomAD
CA9132877 rs775206603	715	V>I		No	ClinGen ExAC gnomAD
CA403635883 rs1366527500	718	I>V		No	ClinGen gnomAD
rs924992440 CA304825499	720	I>V		No	ClinGen TOPMed
CA9132880 rs149330066 RCV000508028	721	M>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA9132879 rs149330066	721	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs267605754 CA304825513	725	G>R		No	ClinGen Ensembl
rs1599683422 CA403635985	727	Y>C		No	ClinGen Ensembl
CA9132882 rs761409372	728	R>L		No	ClinGen ExAC TOPMed gnomAD
CA9132883 rs761409372	728	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1258040454 CA403635993	728	R>W		No	ClinGen gnomAD
rs1390931580 CA403636021	731	E>Q		No	ClinGen TOPMed
rs1568319356 CA403636032	732	K>Q		No	ClinGen Ensembl
rs376389573 CA304825523	734	A>T		No	ClinGen ESP TOPMed gnomAD
COSM3378878 CA304825537 rs752795410	736	R>Q	pancreas [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs766892501 CA9132886	736	R>W		No	ClinGen ExAC gnomAD
CA9132889 rs755335843	737	G>A		No	ClinGen ExAC gnomAD
CA9132888 rs755335843	737	G>E		No	ClinGen ExAC gnomAD
CA9132887 rs199781915	737	G>R		No	ClinGen ExAC gnomAD
VAR_051997 rs36097961 CA9132891	739	T>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA403636517 rs1599685615	745	Y>S		No	ClinGen Ensembl
CA304826087 rs764207188	748	N>Y		No	ClinGen Ensembl
CA304826088 rs1018053400	758	D>N		No	ClinGen TOPMed gnomAD
CA9132926 rs767854229	768	P>A		No	ClinGen ExAC gnomAD
CA9132927 rs767854229	768	P>S		No	ClinGen ExAC gnomAD
rs1017952782 CA304826090	769	E>A		No	ClinGen TOPMed
rs562061494 CA304826091	770	K>R		No	ClinGen Ensembl
rs761088741 CA403636906	771	R>S		No	ClinGen ExAC gnomAD
CA304826093 rs973492510	774	S>R		No	ClinGen TOPMed gnomAD
CA9132929 rs764458602	777	A>E		No	ClinGen ExAC TOPMed gnomAD
rs1258698651 CA403637598	781	T>K		No	ClinGen TOPMed gnomAD
rs1258698651 CA403637602	781	T>R		No	ClinGen TOPMed gnomAD
CA304826235 rs767321559	782	K>E		No	ClinGen TOPMed gnomAD
CA403637789 rs1196572531	790	R>H		No	ClinGen gnomAD
rs1451778734 CA403637873	795	A>T		No	ClinGen gnomAD
rs1197729272 CA403637891	796	R>*		No	ClinGen gnomAD
rs752656112 CA9132953	796	R>Q		No	ClinGen ExAC gnomAD
CA304826239 rs950938415	797	D>N		No	ClinGen Ensembl
COSM3404766 rs1478549387 CA403637911	798	R>*	central_nervous_system [Cosmic]	No	ClinGen cosmic curated gnomAD
CA403637948 rs1599686693	802	S>L		No	ClinGen Ensembl
CA9132955 rs777550036	804	K>T		No	ClinGen ExAC gnomAD
rs866390655 CA304826247	805	E>A		No	ClinGen Ensembl
rs1568321298 CA403638004	806	G>D		No	ClinGen Ensembl
CA9132957 rs756992113	808	I>N		No	ClinGen ExAC gnomAD
CA9132958 rs778399512	813	N>Y		No	ClinGen ExAC gnomAD
CA304826254 rs1023632228	814	K>R		No	ClinGen TOPMed
CA304826255 rs968114947	815	K>R		No	ClinGen TOPMed
CA9132960 rs771728616	816	G>E		No	ClinGen ExAC gnomAD
CA9132959 rs745431526	816	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1225183789 CA403638221	818	Q>E		No	ClinGen gnomAD
rs975206431 CA304826265	819	G>A		No	ClinGen TOPMed
rs779669403 CA9132961	819	G>S		No	ClinGen ExAC TOPMed gnomAD
CA403638264 rs1302126447	820	W>L		No	ClinGen TOPMed
rs1438044972 CA403638291	821	W>*		No	ClinGen TOPMed
rs1488692859 CA403638306	822	R>*		No	ClinGen gnomAD
CA403638308 rs1208856602	822	R>Q		No	ClinGen gnomAD
CA403638344 rs1266409750	824	E>D		No	ClinGen gnomAD
rs922050828 CA304826268	825	I>F		No	ClinGen Ensembl
CA9132964 rs199788005	828	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9132963 rs535090610	828	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs774471900 CA9132990	837	V>M		No	ClinGen ExAC gnomAD
CA304827510 rs866209735	839	E>G		No	ClinGen Ensembl
CA9132991 rs759607376	841	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs764140485 CA9132992	842	S>Y		No	ClinGen ExAC gnomAD
CA403639025 rs1378848011	846	C>S		No	ClinGen TOPMed gnomAD

No associated diseases with P15498

4 regional properties for P15498

Type	Name	Position	InterPro Accession
domain	p53, tetramerisation domain	319 - 357	IPR010991
domain	p53, DNA-binding domain	100 - 289	IPR011615
domain	p53 transactivation domain	6 - 30	IPR013872
domain	Cellular tumor antigen p53, transactivation domain 2	35 - 59	IPR040926

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family	PTHR45818	PROTEIN VAV
PANTHER Subfamily	PTHR45818:SF2	PROTO-ONCOGENE VAV
PANTHER Protein Class
PANTHER Pathway Category	B cell activation vav T cell activation vav PDGF signaling pathway Vav Inflammation mediated by chemokine and cytokine signaling pathway GEF

3 GO annotations of cellular component

Name	Definition
cell-cell junction	A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
metal ion binding	Binding to a metal ion.
phosphorylation-dependent protein binding	Binding to a protein upon phosphorylation of the target protein.
phosphotyrosine residue binding	Binding to a phosphorylated tyrosine residue within a protein.

17 GO annotations of biological process

Name	Definition
Fc-epsilon receptor signaling pathway	The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
Fc-gamma receptor signaling pathway involved in phagocytosis	An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
G protein-coupled receptor signaling pathway	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
immune response	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
integrin-mediated signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
neutrophil chemotaxis	The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
platelet activation	A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
positive regulation of GTPase activity	Any process that activates or increases the activity of a GTPase.
positive regulation of natural killer cell mediated cytotoxicity	Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
reactive oxygen species metabolic process	The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
regulation of cell size	Any process that modulates the size of a cell.
regulation of GTPase activity	Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of small GTPase mediated signal transduction	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
small GTPase mediated signal transduction	The series of molecular signals in which a small monomeric GTPase relays a signal.
T cell costimulation	The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
T cell differentiation	The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
vascular endothelial growth factor receptor signaling pathway	The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q08DN7	VAV1	Proto-oncogene vav	Bos taurus (Bovine)	SS
Q9NHV9	Vav	Protein vav	Drosophila melanogaster (Fruit fly)	SS
P52735	VAV2	Guanine nucleotide exchange factor VAV2	Homo sapiens (Human)	SS
Q9UKW4	VAV3	Guanine nucleotide exchange factor VAV3	Homo sapiens (Human)	SS
Q9R0C8	Vav3	Guanine nucleotide exchange factor VAV3	Mus musculus (Mouse)	SS
Q60992	Vav2	Guanine nucleotide exchange factor VAV2	Mus musculus (Mouse)	SS
P27870	Vav1	Proto-oncogene vav	Mus musculus (Mouse)	EV
P54100	Vav1	Proto-oncogene vav	Rattus norvegicus (Rat)	SS
Q45FX5	vav-1	Protein vav-1	Caenorhabditis elegans	SS

10	20	30	40	50	60
MELWRQCTHW	LIQCRVLPPS	HRVTWDGAQV	CELAQALRDG	VLLCQLLNNL	LPHAINLREV
70	80	90	100	110	120
NLRPQMSQFL	CLKNIRTFLS	TCCEKFGLKR	SELFEAFDLF	DVQDFGKVIY	TLSALSWTPI
130	140	150	160	170	180
AQNRGIMPFP	TEEESVGDED	IYSGLSDQID	DTVEEDEDLY	DCVENEEAEG	DEIYEDLMRS
190	200	210	220	230	240
EPVSMPPKMT	EYDKRCCCLR	EIQQTEEKYT	DTLGSIQQHF	LKPLQRFLKP	QDIEIIFINI
250	260	270	280	290	300
EDLLRVHTHF	LKEMKEALGT	PGAANLYQVF	IKYKERFLVY	GRYCSQVESA	SKHLDRVAAA
310	320	330	340	350	360
REDVQMKLEE	CSQRANNGRF	TLRDLLMVPM	QRVLKYHLLL	QELVKHTQEA	MEKENLRLAL
370	380	390	400	410	420
DAMRDLAQCV	NEVKRDNETL	RQITNFQLSI	ENLDQSLAHY	GRPKIDGELK	ITSVERRSKM
430	440	450	460	470	480
DRYAFLLDKA	LLICKRRGDS	YDLKDFVNLH	SFQVRDDSSG	DRDNKKWSHM	FLLIEDQGAQ
490	500	510	520	530	540
GYELFFKTRE	LKKKWMEQFE	MAISNIYPEN	ATANGHDFQM	FSFEETTSCK	ACQMLLRGTF
550	560	570	580	590	600
YQGYRCHRCR	ASAHKECLGR	VPPCGRHGQD	FPGTMKKDKL	HRRAQDKKRN	ELGLPKMEVF
610	620	630	640	650	660
QEYYGLPPPP	GAIGPFLRLN	PGDIVELTKA	EAEQNWWEGR	NTSTNEIGWF	PCNRVKPYVH
670	680	690	700	710	720
GPPQDLSVHL	WYAGPMERAG	AESILANRSD	GTFLVRQRVK	DAAEFAISIK	YNVEVKHIKI
730	740	750	760	770	780
MTAEGLYRIT	EKKAFRGLTE	LVEFYQQNSL	KDCFKSLDTT	LQFPFKEPEK	RTISRPAVGS
790	800	810	820	830	840
TKYFGTAKAR	YDFCARDRSE	LSLKEGDIIK	ILNKKGQQGW	WRGEIYGRVG	WFPANYVEED

YSEYC