P15424
PR
Gene name |
MSS116 (YDR194C, YD9346.05C) |
Protein name |
ATP-dependent RNA helicase MSS116, mitochondrial |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR194C |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
14 structures for P15424
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3I5X | X-ray | 190 A | A | 37-597 | PDB |
| 3I5Y | X-ray | 249 A | A | 37-597 | PDB |
| 3I61 | X-ray | 210 A | A | 37-597 | PDB |
| 3I62 | X-ray | 195 A | A | 37-597 | PDB |
| 3SQW | X-ray | 191 A | A | 88-664 | PDB |
| 3SQX | X-ray | 211 A | A | 88-597 | PDB |
| 4DB2 | X-ray | 316 A | A/B/C/D | 342-596 | PDB |
| 4DB4 | X-ray | 360 A | A/B | 342-596 | PDB |
| 4TYN | X-ray | 296 A | A | 88-596 | PDB |
| 4TYW | X-ray | 220 A | A | 88-595 | PDB |
| 4TYY | X-ray | 274 A | A | 88-596 | PDB |
| 4TZ0 | X-ray | 235 A | A | 88-596 | PDB |
| 4TZ6 | X-ray | 321 A | A | 88-596 | PDB |
| AF-P15424-F1 | Predicted | AlphaFoldDB |
12 variants for P15424
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-847850 | 32 | A>T | No | SGRP | |
| s04-847819 | 42 | N>S | No | SGRP | |
| s04-847793 | 51 | N>Y | No | SGRP | |
| s04-847732 | 71 | T>R | No | SGRP | |
| s04-847334 | 204 | H>N | No | SGRP | |
| s04-846835 | 370 | R>K | No | SGRP | |
| s04-846784 | 387 | S>Y | No | SGRP | |
| s04-846563 | 461 | I>V | No | SGRP | |
| s04-846452 | 498 | V>I | No | SGRP | |
| s04-846134 | 604 | N>D | No | SGRP | |
| s04-846043 | 634 | D>V | No | SGRP | |
| s04-845956 | 663 | I>R | No | SGRP |
No associated diseases with P15424
4 regional properties for P15424
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 339 - 347 | IPR000629 |
| domain | Helicase, C-terminal | 426 - 579 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 198 - 387 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 193 - 414 | IPR014001 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| RNA strand annealing activity | An activity that facilitates the formation of a complementary double-stranded RNA molecule. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| Group I intron splicing | The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize). |
| Group II intron splicing | The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. |
| mitochondrial RNA processing | The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. |
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| RNA folding | The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
| transcription elongation by mitochondrial RNA polymerase | The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P10081 | TIF2 | ATP-dependent RNA helicase eIF4A | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P53166 | MRH4 | ATP-dependent RNA helicase MRH4, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q03532 | HAS1 | ATP-dependent RNA helicase HAS1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q06218 | DBP9 | ATP-dependent RNA helicase DBP9 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P20448 | HCA4 | ATP-dependent RNA helicase HCA4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P32892 | DRS1 | ATP-dependent RNA helicase DRS1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P21372 | PRP5 | Pre-mRNA-processing ATP-dependent RNA helicase PRP5 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| P45818 | ROK1 | ATP-dependent RNA helicase ROK1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q29S22 | DDX47 | Probable ATP-dependent RNA helicase DDX47 | Bos taurus (Bovine) | PR |
| Q9H0S4 | DDX47 | Probable ATP-dependent RNA helicase DDX47 | Homo sapiens (Human) | PR |
| Q9CWX9 | Ddx47 | Probable ATP-dependent RNA helicase DDX47 | Mus musculus (Mouse) | PR |
| Q7Y183 | RH10 | DEAD-box ATP-dependent RNA helicase 10 | Oryza sativa subsp japonica (Rice) | PR |
| Q8L4E9 | Os07g0633500 | DEAD-box ATP-dependent RNA helicase 36 | Oryza sativa subsp japonica (Rice) | PR |
| P34668 | ZK686.2 | Putative ATP-dependent RNA helicase ZK686.2 | Caenorhabditis elegans | PR |
| P34580 | T26G10.1 | Putative ATP-dependent RNA helicase T26G10.1 | Caenorhabditis elegans | PR |
| Q9SA27 | RH36 | DEAD-box ATP-dependent RNA helicase 36 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GY84 | RH10 | DEAD-box ATP-dependent RNA helicase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLTSILIKGR | TPVLASRNLL | AALSNCNHIT | WAVSRRLYND | GNRDQRNFGR | NQRNNNSNRY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RNSRFNSRPR | TRSREDDDEV | HFDKTTFSKL | IHVPKEDNSK | EVTLDSLLEE | GVLDKEIHKA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ITRMEFPGLT | PVQQKTIKPI | LSSEDHDVIA | RAKTGTGKTF | AFLIPIFQHL | INTKFDSQYM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VKAVIVAPTR | DLALQIEAEV | KKIHDMNYGL | KKYACVSLVG | GTDFRAAMNK | MNKLRPNIVI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ATPGRLIDVL | EKYSNKFFRF | VDYKVLDEAD | RLLEIGFRDD | LETISGILNE | KNSKSADNIK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TLLFSATLDD | KVQKLANNIM | NKKECLFLDT | VDKNEPEAHE | RIDQSVVISE | KFANSIFAAV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EHIKKQIKER | DSNYKAIIFA | PTVKFTSFLC | SILKNEFKKD | LPILEFHGKI | TQNKRTSLVK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RFKKDESGIL | VCTDVGARGM | DFPNVHEVLQ | IGVPSELANY | IHRIGRTARS | GKEGSSVLFI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CKDELPFVRE | LEDAKNIVIA | KQEKYEPSEE | IKSEVLEAVT | EEPEDISDIV | ISLISSYRSC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IKEYRFSERR | ILPEIASTYG | VLLNDPQLKI | PVSRRFLDKL | GLSRSPIGKA | MFEIRDYSSR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DGNNKSYDYD | DDSEISFRGN | KNYNNRSQNR | DYDDEPFRRS | NNNRRSFSRS | NDKNNYSSRN |
| SNIY |