AiPD: Autoinhibited Protein Database

P15408

Gene name	FOSL2 (FRA2)
Protein name	Fos-related antigen 2
Names	FRA-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2355
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

192-265 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

192-265 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P15408

Entry ID	Method	Resolution	Chain	Position	Source
AF-P15408-F1	Predicted				AlphaFoldDB

230 variants for P15408

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1381326754 CA346580767	2	Y>S		No	ClinGen TOPMed
rs1255262408 CA346580802	4	D>N		No	ClinGen gnomAD
CA1586424 rs143477470	6	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs865778769 CA44762077	7	G>R		No	ClinGen gnomAD
CA346580875 rs1487695758	7	G>V		No	ClinGen gnomAD
rs865778769 CA44762090	7	G>W		No	ClinGen gnomAD
CA1586426 rs768147671	12	S>L		No	ClinGen ExAC gnomAD
TCGA novel	16	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	17	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346581115 rs1376321882	17	S>R		No	ClinGen gnomAD
CA346581144 rs1436793187	19	S>F		No	ClinGen gnomAD
rs752807740 CA1586427	23	A>P		No	ClinGen ExAC gnomAD
rs1363987281 CA346581227	24	E>D		No	ClinGen gnomAD
CA346581216 rs1390300462	24	E>K		No	ClinGen gnomAD
rs924334625 CA44762142	27	S>C		No	ClinGen TOPMed gnomAD
rs201505339 CA1586429	28	S>G		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs1572480667 CA346581267	28	S>I		No	ClinGen Ensembl
rs1235996105 CA346581276	30	G>S		No	ClinGen gnomAD
rs1352257478 CA346581284	31	G>C		No	ClinGen gnomAD
rs778642185 CA1586435	33	Q>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	36	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1586454 rs140097788	37	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs757435920 CA1586453	37	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1290978558 CA346582566	38	V>L		No	ClinGen gnomAD
CA1586455 rs543868976	39	D>H		No	ClinGen 1000Genomes ExAC gnomAD
CA44771018 rs751769224	40	M>T		No	ClinGen gnomAD
rs1436464399 CA346582600	43	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs966114128 CA44771019	43	S>P		No	ClinGen TOPMed
TCGA novel	44	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1233684575 CA346582610	45	S>C		No	ClinGen gnomAD
CA1586457 rs779943173	45	S>T		No	ClinGen ExAC gnomAD
rs1188984583 CA346582643	50	T>S		No	ClinGen TOPMed
rs997476425 CA44771042	51	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs560133888 CA44771048	53	A>T		No	ClinGen Ensembl
rs868092010 CA44771062	55	T>K		No	ClinGen gnomAD
CA346582678 rs868092010	55	T>M		No	ClinGen gnomAD
CA346582681 rs1572489780	56	T>P		No	ClinGen Ensembl
rs1399223351 CA346582715	61	Q>E		No	ClinGen gnomAD
CA1586463 rs773062179	61	Q>H		No	ClinGen ExAC gnomAD
rs759951831 CA1586464	64	V>G		No	ClinGen ExAC gnomAD
CA346582750 rs775742575	65	Q>H		No	ClinGen ExAC gnomAD
rs761206290 CA1586467	67	T>A		No	ClinGen ExAC gnomAD
rs1356841027 CA346582769	69	I>L		No	ClinGen gnomAD
rs1572489832 CA346582776	70	T>P		No	ClinGen Ensembl
CA1586470 rs761856803	72	M>I		No	ClinGen ExAC gnomAD
CA1586469 rs776715677	72	M>V		No	ClinGen ExAC TOPMed gnomAD
CA346582795 rs1216680226	73	S>T		No	ClinGen gnomAD
CA1586471 rs765442032	74	N>S		No	ClinGen ExAC gnomAD
CA346582809 rs1442022816	75	P>A		No	ClinGen TOPMed gnomAD
CA346582817 rs1572489875	76	Y>S		No	ClinGen Ensembl
CA1586472 rs371248680	78	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1586473 rs375020008	78	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs766121698 CA1586474	79	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1572489895 CA346582840	80	H>P		No	ClinGen Ensembl
CA44771207 rs977739536	80	H>Q		No	ClinGen TOPMed
rs1032108254 CA44771209	83	S>G		No	ClinGen Ensembl
COSM167640 rs199613963 CA1586476	83	S>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
CA1586478 rs781046221	84	P>S		No	ClinGen ExAC TOPMed gnomAD
rs781046221 CA1586477	84	P>T		No	ClinGen ExAC TOPMed gnomAD
rs189699153 CA1586480	86	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA44771217 rs990728026	86	P>S		No	ClinGen Ensembl
rs376695330 CA44771234	89	A>S		No	ClinGen Ensembl
CA346582897 rs1425715252	90	S>C		No	ClinGen TOPMed
rs1297111753 CA346582925	95	M>L		No	ClinGen gnomAD
CA346582934 rs1325198099	96	A>T		No	ClinGen gnomAD
rs769194572 CA1586485	98	P>L		No	ClinGen ExAC gnomAD
rs1232311729 CA346582970	102	V>M		No	ClinGen TOPMed gnomAD
TCGA novel	103	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1586488 rs765250369	105	T>A		No	ClinGen ExAC gnomAD
CA346582995 rs1486273378	105	T>S		No	ClinGen TOPMed
CA346582998 rs1215968211	106	I>F		No	ClinGen gnomAD
CA346582997 rs1215968211	106	I>V		No	ClinGen gnomAD
CA346583010 rs1259791802	108	T>A		No	ClinGen gnomAD
CA44771275 rs1056247953	108	T>I		No	ClinGen TOPMed gnomAD
CA346583013 rs1056247953	108	T>S		No	ClinGen TOPMed gnomAD
rs773309299 CA1586489	109	T>A		No	ClinGen ExAC gnomAD
rs766520219 CA1586491	110	V>M		No	ClinGen ExAC gnomAD
CA346583032 rs1171301931	112	R>C		No	ClinGen TOPMed gnomAD
CA1586492 rs768637618 COSM302262	112	R>H	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA1586494 rs754792175	118	Q>H		No	ClinGen ExAC TOPMed
TCGA novel	118	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369462754 CA1586509	121	P>L		No	ClinGen ESP ExAC gnomAD
TCGA novel	125	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771178098 CA1586510	126	K>R		No	ClinGen ExAC gnomAD
COSM244578 CA346583587 rs1305140602	127	R>C	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs774472349 CA1586511	127	R>H		No	ClinGen ExAC gnomAD
CA44774431 rs1007176760	128	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1286334066 CA346583601 COSM1019895	128	R>H	autonomic_ganglia endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1334038053 CA346583639	131	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1586513 rs767171135	133	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	135	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346583767 rs1194806367	139	A>P		No	ClinGen gnomAD
rs1483276579 COSM379198 CA346583850	144	R>*	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1474485068 COSM1019896 CA346583867	145	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	154	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346584013 rs1416380727	154	A>T		No	ClinGen gnomAD
rs1398906591 CA346584020	154	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1344736363 CA346584516	156	T>I		No	ClinGen gnomAD
CA1586550 rs746771459	161	E>K		No	ClinGen ExAC gnomAD
TCGA novel	163	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1236100930 CA346584592	167	Q>L		No	ClinGen gnomAD
CA1586554 rs765234560	172	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	177	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	178	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	181	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772582818 CA1586555	181	E>K		No	ClinGen ExAC gnomAD
CA1586557 rs765982810	188	G>S		No	ClinGen ExAC TOPMed gnomAD
rs754644292 CA1586559	190	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	193	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	193	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1002167562 CA44777193	194	S>C		No	ClinGen Ensembl
rs754237830 CA1586561	194	S>N		No	ClinGen ExAC gnomAD
rs373180507 CA1586563	194	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs758593606 CA1586565	195	P>L		No	ClinGen ExAC TOPMed gnomAD
rs765494812 CA1586564	195	P>S		No	ClinGen ExAC TOPMed gnomAD
rs747180203 CA1586567	196	E>K		No	ClinGen ExAC gnomAD
TCGA novel	197	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1586568 rs757946261	198	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1586569 rs145499484	198	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	199	R>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1586570 rs143327177	199	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	199	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1252672 CA1586571 rs143327177	199	R>Q	Variant assessed as Somatic; 0.0 impact. oesophagus large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs773239010 CA1586572	200	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA346584810 rs1275081914	200	S>T		No	ClinGen gnomAD
CA346584817 rs1308604850	201	P>S		No	ClinGen gnomAD
CA346584815 rs1308604850	201	P>T		No	ClinGen gnomAD
TCGA novel	202	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346584823 rs1330390281	202	P>T		No	ClinGen gnomAD
rs112106981 CA44777271	203	A>P		No	ClinGen TOPMed
CA346584827 rs112106981	203	A>T		No	ClinGen TOPMed
rs1285238959 CA346584831	203	A>V		No	ClinGen TOPMed
CA346584833 rs1271607644	204	P>A		No	ClinGen TOPMed gnomAD
rs1271607644 CA346584834	204	P>S		No	ClinGen TOPMed gnomAD
TCGA novel	204	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM140411 CA1586575 rs773878073	206	L>M	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	206	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	207	Q>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1232504278 CA346584861	208	P>L		No	ClinGen gnomAD
CA346584858 rs1222511377	208	P>S		No	ClinGen TOPMed gnomAD
rs759126582 CA1586576	209	M>V		No	ClinGen ExAC TOPMed gnomAD
CA1586577 rs767175362	210	R>C		No	ClinGen ExAC TOPMed gnomAD
CA346584871 rs767175362	210	R>G		No	ClinGen ExAC TOPMed gnomAD
CA1586578 rs377464718	210	R>H	Variant assessed as Somatic; 0.0001138 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA346584872 rs377464718	210	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1164160534 CA346584875	211	S>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1572496993 COSM3391684 CA346584877	211	S>N	pancreas [Cosmic]	No	ClinGen cosmic curated Ensembl
rs757710364 CA1586579	211	S>R		No	ClinGen ExAC gnomAD
CA1586581 rs371015391	212	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs371015391 CA1586580	212	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA346584884 rs371015391	212	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA1586582 rs758997365	213	G>A		No	ClinGen ExAC TOPMed gnomAD
CA346584888 rs758997365	213	G>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	213	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs145636135 CA1586585	215	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1586583 rs780242445	215	S>P		No	ClinGen ExAC gnomAD
rs145636135 CA1586584	215	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs747862760 CA346584901	216	V>L		No	ClinGen ExAC TOPMed gnomAD
rs747862760 CA1586587	216	V>M		No	ClinGen ExAC TOPMed gnomAD
rs777446398 CA346584912	218	A>S		No	ClinGen ExAC TOPMed gnomAD
CA1586589 rs777446398	218	A>T		No	ClinGen ExAC TOPMed gnomAD
rs749206799 CA1586590	220	V>M		No	ClinGen ExAC gnomAD
TCGA novel	222	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM3380135 CA44777394 rs953667563	223	Q>E	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
rs773795996 CA1586592	223	Q>R		No	ClinGen ExAC gnomAD
CA44777411 COSM1019898 rs759108536	225	P>A	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs759108536 CA1586593	225	P>S		No	ClinGen ExAC TOPMed gnomAD
rs759108536 CA1586594	225	P>T		No	ClinGen ExAC TOPMed gnomAD
CA346584982 rs1572497097	229	D>A		No	ClinGen Ensembl
CA346584991 rs986432034	229	D>E		No	ClinGen gnomAD
rs1255306492 CA346584979	229	D>N		No	ClinGen gnomAD
rs577454302 CA1586596	232	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	233	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs534806089 CA1586598	234	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1586600 rs374401510	235	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs149210102 CA1586602	236	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs143256884 CA1586603	236	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA346585078 rs1297807723	237	G>V		No	ClinGen TOPMed
CA346585090 rs1360346178	238	L>P		No	ClinGen gnomAD
rs1572497155 CA346585085	238	L>V		No	ClinGen Ensembl
CA44777509 rs142091179	239	D>E		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs777554902 CA1586606	239	D>G		No	ClinGen ExAC
CA346585093 rs756318917	239	D>N		No	ClinGen ExAC gnomAD
rs756318917 CA1586605	239	D>Y		No	ClinGen ExAC gnomAD
CA1586607 rs749097522	243	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs770844148 CA44777516	243	R>H		No	ClinGen ExAC TOPMed gnomAD
rs770844148 CA1586608	243	R>P		No	ClinGen ExAC TOPMed gnomAD
CA346585167 rs1282616618	244	S>F		No	ClinGen gnomAD
CA346585181 rs778892052	246	I>L		No	ClinGen ExAC gnomAD
rs778892052 CA1586609	246	I>V		No	ClinGen ExAC gnomAD
rs1188194167 CA346585205	247	K>M		No	ClinGen gnomAD
CA346585211 rs1241264764	248	P>T		No	ClinGen gnomAD
TCGA novel	249	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1586610 rs745354892	249	I>V		No	ClinGen ExAC gnomAD
rs771662567 CA1586611	250	S>G		No	ClinGen ExAC TOPMed gnomAD
rs750975060 CA1586612	252	A>G		No	ClinGen ExAC TOPMed gnomAD
CA346585280 rs1433755842	253	G>E		No	ClinGen gnomAD
CA346585277 rs1433755842	253	G>V		No	ClinGen gnomAD
CA1586614 rs138278678	254	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs760337334 CA1586613	254	G>S		No	ClinGen ExAC gnomAD
rs766961451 CA346585324	257	G>D		No	ClinGen ExAC TOPMed gnomAD
rs763475600 CA1586616	257	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs766961451 CA1586617	257	G>V		No	ClinGen ExAC TOPMed gnomAD
rs752159907 CA1586618	258	E>G		No	ClinGen ExAC TOPMed gnomAD
rs760137820 CA1586619	263	T>S		No	ClinGen ExAC gnomAD
CA1586621 rs752720566	264	P>S		No	ClinGen ExAC TOPMed gnomAD
CA1586622 rs756305870	265	I>V		No	ClinGen ExAC gnomAD
rs753630093 CA1586624	266	V>M		No	ClinGen ExAC TOPMed gnomAD
CA1586625 rs545401735	267	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs970544007 CA44777629	270	T>A		No	ClinGen TOPMed gnomAD
CA346585485 rs1445278571	272	A>V		No	ClinGen gnomAD
rs778801664 CA1586626	274	T>A		No	ClinGen ExAC TOPMed gnomAD
CA346585506 rs1248462650	274	T>I		No	ClinGen gnomAD
rs552837522 CA1586627	275	P>L		No	ClinGen ExAC TOPMed gnomAD
CA1586628 rs552837522	275	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs746558059 CA1586630	277	T>I		No	ClinGen ExAC TOPMed gnomAD
rs746558059 CA346585537	277	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1157549490 CA346585550	278	S>L		No	ClinGen gnomAD
rs771370706 CA1586634	281	V>I		No	ClinGen ExAC TOPMed gnomAD
CA346585587 rs1572497336	283	T>N		No	ClinGen Ensembl
rs1331696016 CA346585612	287	V>I		No	ClinGen TOPMed gnomAD
TCGA novel	289	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1028067701 CA44777709	291	E>A		No	ClinGen Ensembl
rs370838431 CA1586640	294	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs370838431 CA1586639	294	A>T	Variant assessed as Somatic; 4.841e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1586641 rs754112385	295	S>T		No	ClinGen ExAC gnomAD
CA346585669 rs1211368629	296	P>S		No	ClinGen gnomAD
TCGA novel	303	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346585772 rs1451894398	310	S>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA346585776 rs1361613342	311	G>R		No	ClinGen gnomAD

No associated diseases with P15408

2 regional properties for P15408

Type	Name	Position	InterPro Accession
domain	Nuclear hormone receptor, ligand-binding domain	146 - 433	IPR000536
domain	Zinc finger, nuclear hormone receptor-type	38 - 114	IPR001628

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase II transcription regulator complex	A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.

6 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.

5 GO annotations of biological process

Name	Definition
cell death	Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
keratinocyte development	The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure.
positive regulation of fibroblast proliferation	Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O93602	ATF2	Cyclic AMP-dependent transcription factor ATF-2	Gallus gallus (Chicken)	SS
P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	Homo sapiens (Human)	EV
Q02930	CREB5	Cyclic AMP-responsive element-binding protein 5	Homo sapiens (Human)	SS
P17544	ATF7	Cyclic AMP-dependent transcription factor ATF-7	Homo sapiens (Human)	PR
Q8R0S1	Atf7	Cyclic AMP-dependent transcription factor ATF-7	Mus musculus (Mouse)	PR
P16951	Atf2	Cyclic AMP-dependent transcription factor ATF-2	Mus musculus (Mouse)	SS
P47930	Fosl2	Fos-related antigen 2	Mus musculus (Mouse)	PR
Q00969	Atf2	Cyclic AMP-dependent transcription factor ATF-2	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MYQDYPGNFD	TSSRGSSGSP	AHAESYSSGG	GGQQKFRVDM	PGSGSAFIPT	INAITTSQDL
70	80	90	100	110	120
QWMVQPTVIT	SMSNPYPRSH	PYSPLPGLAS	VPGHMALPRP	GVIKTIGTTV	GRRRRDEQLS
130	140	150	160	170	180
PEEEEKRRIR	RERNKLAAAK	CRNRRRELTE	KLQAETEELE	EEKSGLQKEI	AELQKEKEKL
190	200	210	220	230	240
EFMLVAHGPV	CKISPEERRS	PPAPGLQPMR	SGGGSVGAVV	VKQEPLEEDS	PSSSSAGLDK
250	260	270	280	290	300
AQRSVIKPIS	IAGGFYGEEP	LHTPIVVTST	PAVTPGTSNL	VFTYPSVLEQ	ESPASPSESC
310	320
SKAHRRSSSS	GDQSSDSLNS	PTLLAL