P15127

SS
Gene name
Insr
Protein name
Insulin receptor
Names
IR , EC 2.7.10.1 , CD antigen CD220 [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

Insulin-like growth factor 1 receptor(IGF-I receptor). The JM(juxtamembrane) region of the human insulin-like growth factor I receptor (IGF1R) plays a role in kinase regulation. The JM region is involved in regulating IGF1R activity by inhibiting the autophosphorylation activity of the kinase. The JM region of IGF1R also plays an important role in limiting the basal activity of the receptor.

Autoinhibitory domains (AIDs)

51-162 (L1 domain) SS

Target domain

1024-1299 (FnIII-2 domain)

Relief mechanism

PTM

Assay

Accessory elements

1177-1202 (Activation loop from InterPro)

Target domain

1024-1299 (Protein kinase domain)

Relief mechanism

Assay

1177-1202 (Activation loop from InterPro)

Target domain

1024-1299 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

3 structures for P15127

Entry ID Method Resolution Chain Position Source
4XST X-ray 300 A F 726-748 PDB
5TQ1 X-ray 149 A B 1008-1018 PDB
AF-P15127-F1 Predicted AlphaFoldDB

No variants for P15127

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P15127

No associated diseases with P15127

12 regional properties for P15127

Type Name Position InterPro Accession
domain Death domain 805 - 892 IPR000488
repeat Ankyrin repeat 542 - 572 IPR002110-1
repeat Ankyrin repeat 581 - 682 IPR002110-2
repeat Ankyrin repeat 684 - 717 IPR002110-3
repeat Ankyrin repeat 718 - 750 IPR002110-4
domain IPT domain 249 - 350 IPR002909
domain Rel homology domain, DNA-binding domain 39 - 246 IPR011539
conserved_site Rel homology domain, conserved site 57 - 63 IPR030492
domain Nuclear factor NF-kappa-B, p105 subunit, Rel homology domain, N-terminal 42 - 243 IPR030503
domain Rel homology dimerisation domain 251 - 352 IPR032397
domain NFkappaB IPT domain 250 - 351 IPR033926
domain Nuclear factor NF-kappa-B p105 subunit, death domain 815 - 890 IPR047096

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Late endosome
  • Lysosome
  • Binding of insulin to INSR induces internalization and lysosomal degradation of the receptor, a means for down-regulating this signaling pathway after stimulation
  • In the presence of SORL1, internalized INSR molecules are redirected back to the cell surface, thereby preventing their lysosomal catabolism and strengthening insulin signal reception
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

14 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
caveola A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
dendrite membrane The portion of the plasma membrane surrounding a dendrite.
endosome A vacuole to which materials ingested by endocytosis are delivered.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
insulin receptor complex A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.
late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
neuronal cell body membrane The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
yolk The cytoplasmic part that serves as a nutrient reserve or energy source for the developing embryo.

21 GO annotations of molecular function

Name Definition
3-phosphoinositide-dependent protein kinase binding Binding to a 3-phosphoinositide-dependent protein kinase.
amyloid-beta binding Binding to an amyloid-beta peptide/protein.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cargo receptor activity Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
GTP binding Binding to GTP, guanosine triphosphate.
insulin binding Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
insulin receptor activity Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
insulin receptor substrate binding Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
insulin-like growth factor I binding Binding to insulin-like growth factor I.
insulin-like growth factor II binding Binding to insulin-like growth factor II.
insulin-like growth factor receptor binding Binding to an insulin-like growth factor receptor.
lipoic acid binding Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid.
phosphatidylinositol 3-kinase binding Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
protein domain specific binding Binding to a specific domain of a protein.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein phosphatase binding Binding to a protein phosphatase.
protein tyrosine kinase activity Catalysis of the reaction
protein-containing complex binding Binding to a macromolecular complex.
PTB domain binding Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain.
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex.

71 GO annotations of biological process

Name Definition
adrenal gland development The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.
amyloid-beta clearance The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
cellular response to growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
cellular response to insulin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
cellular response to zinc ion starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions.
cerebellum development The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
dendritic spine maintenance The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
embryonic liver development The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure.
epidermis development The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
exocrine pancreas development The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.
fat cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
glucose homeostasis Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
heart morphogenesis The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
hippocampus development The progression of the hippocampus over time from its initial formation until its mature state.
insulin receptor signaling pathway The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
liver development The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
liver regeneration The regrowth of lost or destroyed liver.
male gonad development The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
male sex determination The specification of male sex of an individual organism.
negative regulation of feeding behavior Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of glycogen biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
negative regulation of protein phosphorylation Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
neuron projection maintenance The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of developmental growth Any process that activates, maintains or increases the rate of developmental growth.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of glucose import Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
positive regulation of glycogen biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
positive regulation of glycolytic process Any process that activates or increases the frequency, rate or extent of glycolysis.
positive regulation of glycoprotein biosynthetic process Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of meiotic cell cycle Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.
positive regulation of mitotic nuclear division Any process that activates or increases the frequency, rate or extent of mitosis.
positive regulation of nitric oxide biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
positive regulation of phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of protein-containing complex disassembly Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
positive regulation of receptor internalization Any process that activates or increases the frequency, rate or extent of receptor internalization.
positive regulation of respiratory burst Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
receptor internalization A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
receptor-mediated endocytosis An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of embryonic development Any process that modulates the frequency, rate or extent of embryonic development.
regulation of female gonad development Any process that modulates the frequency, rate or extent of female gonad development.
regulation of gluconeogenesis Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
regulation of hydrogen peroxide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide.
response to activity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
response to estradiol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
response to ethanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
response to food Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.
response to glucocorticoid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
response to glucose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
response to hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to insulin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
response to manganese ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
response to nutrient levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
response to organic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
response to resveratrol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus.
response to starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
response to testosterone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
response to tumor necrosis factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
response to vanadate(3-) Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus.
response to vitamin D Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
symbiont entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.

48 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q05688 IGF1R Insulin-like growth factor 1 receptor Bos taurus (Bovine) SS
P09208 InR Insulin-like receptor Drosophila melanogaster (Fruit fly) SS
P08069 IGF1R Insulin-like growth factor 1 receptor Homo sapiens (Human) EV
P14616 INSRR Insulin receptor-related protein Homo sapiens (Human) SS
P06213 INSR Insulin receptor Homo sapiens (Human) EV
Q60751 Igf1r Insulin-like growth factor 1 receptor Mus musculus (Mouse) SS
Q9WTL4 Insrr Insulin receptor-related protein Mus musculus (Mouse) SS
P15208 Insr Insulin receptor Mus musculus (Mouse) SS
P24062 Igf1r Insulin-like growth factor 1 receptor Rattus norvegicus (Rat) SS
Q64716 Insrr Insulin receptor-related protein Rattus norvegicus (Rat) SS
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
P57097 Mertk Tyrosine-protein kinase Mer Rattus norvegicus (Rat) SS
Q62838 Musk Muscle, skeletal receptor tyrosine protein kinase Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
G3V9H8 Ret Proto-oncogene tyrosine-protein kinase receptor Ret Rattus norvegicus (Rat) SS
Q63474 Ddr1 Epithelial discoidin domain-containing receptor 1 Rattus norvegicus (Rat) SS
Q91ZT1 Flt4 Vascular endothelial growth factor receptor 3 Rattus norvegicus (Rat) SS
P53767 Flt1 Vascular endothelial growth factor receptor 1 Rattus norvegicus (Rat) PR
O08775 Kdr Vascular endothelial growth factor receptor 2 Rattus norvegicus (Rat) SS
Q04589 Fgfr1 Fibroblast growth factor receptor 1 Rattus norvegicus (Rat) SS
Q498D6 Fgfr4 Fibroblast growth factor receptor 4 Rattus norvegicus (Rat) PR
P06494 Erbb2 Receptor tyrosine-protein kinase erbB-2 Rattus norvegicus (Rat) SS
Q62956 Erbb4 Receptor tyrosine-protein kinase erbB-4 Rattus norvegicus (Rat) SS
Q62799 Erbb3 Receptor tyrosine-protein kinase erbB-3 Rattus norvegicus (Rat) SS
Q05030 Pdgfrb Platelet-derived growth factor receptor beta Rattus norvegicus (Rat) SS
P20786 Pdgfra Platelet-derived growth factor receptor alpha Rattus norvegicus (Rat) SS
Q00495 Csf1r Macrophage colony-stimulating factor 1 receptor Rattus norvegicus (Rat) PR
Q9SXB5 At1g11303 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LMN7 WAK5 Wall-associated receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
O64783 At1g61370 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 Arabidopsis thaliana (Mouse-ear cress) SS
O64770 At1g61490 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SYA0 At1g61500 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 Arabidopsis thaliana (Mouse-ear cress) SS
O64793 At1g67520 G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LW83 CES101 G-type lectin S-receptor-like serine/threonine-protein kinase CES101 Arabidopsis thaliana (Mouse-ear cress) PR
O81833 SD11 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 Arabidopsis thaliana (Mouse-ear cress) PR
O64780 At1g61400 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 Arabidopsis thaliana (Mouse-ear cress) SS
O64778 At1g61420 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 Arabidopsis thaliana (Mouse-ear cress) SS
O64776 At1g61440 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 Arabidopsis thaliana (Mouse-ear cress) SS
O64477 At2g19130 G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 Arabidopsis thaliana (Mouse-ear cress) SS
Q39203 SD22 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2 Arabidopsis thaliana (Mouse-ear cress) SS
O64774 At1g61460 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 Arabidopsis thaliana (Mouse-ear cress) PR
O64782 SD129 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
O64784 At1g61360 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SY95 At1g61550 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MGSGRGCETT AVPLLMAVAV AGGTAGHLYP GEVCPGMDIR NNLTRLHELE NCSVIEGHLQ
70 80 90 100 110 120
ILLMFKTRPE DFRDLSFPKL IMITDYLLLF RVYGLESLKD LFPNLTVIRG SRLFFNYALV
130 140 150 160 170 180
IFEMVHLKEL GLYNLMNITR GSVRIEKNNE LCYLATIDWS RILDYVEDNY IVLNKDDNEE
190 200 210 220 230 240
CGDVCPGTAK GKTNCPATVI NGQFVERCWT HSHCQKVCPT ICKSHGCTAE GLCCHKECLG
250 260 270 280 290 300
NCSEPDDPTK CVACRNFYLD GQCVETCPPP YYHFQDWRCV NFSFCQDLHY KCRNSRKPGC
310 320 330 340 350 360
HQYVIHNNKC IPECPSGYTM NSSNLMCTPC LGPCPKVCQI LEGEKTIDSV TSAQELRGCT
370 380 390 400 410 420
VINGSLIINI RGGNNLAAEL EANLGLIEEI SGFLKIRRSY ALVSLSFFRK LHLIRGETLE
430 440 450 460 470 480
IGNYSFYALD NQNLRQLWDW NKHNLTITQG KLFFHYNPKL CLSEIHKMEE VSGTKGRQER
490 500 510 520 530 540
NDIALKTNGD QASCENELLK FSFIRTSFDK ILLRWEPYWP PDFRDLLGFM LFYKEAPYQN
550 560 570 580 590 600
VTEFDGQDAC GSNSWTVVDI DPPQRSNDPK SQTPSHPGWL MRGLKPWTQY AIFVKTLVTF
610 620 630 640 650 660
SDERRTYGAK SDIIYVQTDA TNPSVPLDPI SVSNSSSQII LKWKPPSDPN GNITHYLVYW
670 680 690 700 710 720
ERQAEDSELF ELDYCLKGLK LPSRTWSPPF ESDDSQKHNQ SEYDDSASEC CSCPKTDSQI
730 740 750 760 770 780
LKELEESSFR KTFEDYLHNV VFVPRKTSSG NGAEDTRPSR KRRSLEEVGN VTATTPTLPD
790 800 810 820 830 840
FPNISSTIAP TSHEEHRPFE KVVNKESLVI SGLRHFTGYR IELQACNQDS PEERSGVAAY
850 860 870 880 890 900
VSARTMPEAK ADDIVGPVTH EIFENNVVHL MWQEPKEPNG LIVLYEVSYR RYGDEELHLC
910 920 930 940 950 960
VSRKHFALER GCRLRGLSPG NYSVRVRATS LAGNGSWTEP TYFYVTDYLD VPSNIAKIII
970 980 990 1000 1010 1020
GPLIFVFLFS VVIGSIYLFL RKRQPDGPMG PLYASSNPEY LSASDVFPSS VYVPDEWEVP
1030 1040 1050 1060 1070 1080
REKITLLREL GQGSFGMVYE GNAKDIIKGE VETRVAVKTV NESASLRERI EFLNEASVMK
1090 1100 1110 1120 1130 1140
GFTCHHVVRL LGVVSKGQPT LVVMELMAHG DLKSHLRSLR PDAENNPGRP PPTLQEMIQM
1150 1160 1170 1180 1190 1200
TAEIADGMAY LNAKKFVHRD LAARNCMVAH DFTVKIGDFG MTRDIYETDY YRKGGKGLLP
1210 1220 1230 1240 1250 1260
VRWMSPESLK DGVFTASSDM WSFGVVLWEI TSLAEQPYQG LSNEQVLKFV MDGGYLDPPD
1270 1280 1290 1300 1310 1320
NCPERLTDLM RMCWQFNPKM RPTFLEIVNL LKDDLHPSFP EVSFFYSEEN KAPESEELEM
1330 1340 1350 1360 1370 1380
EFEDMENVPL DRSSHCQREE AGCREGGSSL SIKRTYDEHI PYTHMNGGKK NGRVLTLPRS
NPS