P15037

SS
Gene name
Ets2
Protein name
Protein C-ets-2
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:23872
EC number
Protein Class

Descriptions

Ets1 is a transcription factor directly controlling the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. Truncation of either the N-terminal inhibitory region (residues 280-330) or the C-terminal inhibitory region (residues 416-440) increases the DNA binding affinity of Ets-1 by 10- to 20-fold, indicating that the two inhibitory regions act in concert to impair DNA binding

Autoinhibitory domains (AIDs)

330-336 (Alpha-helix HI-1 in N-terminal inhibitory region) SS

Target domain

358-442 (ETS domain)

Relief mechanism

Partner binding

Assay

443-468 (C-terminal inhibitory region) SS

Target domain

358-442 (ETS domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P15037

Entry ID Method Resolution Chain Position Source
AF-P15037-F1 Predicted AlphaFoldDB

16 variants for P15037

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389418512 19 F>S No EVA
rs3389425567 45 E>D No EVA
rs3389407204 61 H>Y No EVA
rs3389341188 208 Q>* No EVA
rs3389422133 210 P>Q No EVA
rs3389426611 215 D>N No EVA
rs3389445228 217 L>H No EVA
rs3389407213 226 A>P No EVA
rs3389376868 305 Q>* No EVA
rs3389437111 312 S>G No EVA
rs3389407254 314 E>D No EVA
rs3389341214 346 P>S No EVA
rs3389418559 398 V>D No EVA
rs3389445177 409 P>T No EVA
rs3389422138 443 C>F No EVA
rs3389434650 463 Q>E No EVA

No associated diseases with P15037

3 regional properties for P15037

Type Name Position InterPro Accession
domain Ets domain 361 - 446 IPR000418
domain Pointed domain 85 - 170 IPR003118
domain Ets1, N-terminal flanking region of Ets domain 245 - 358 IPR045688

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

8 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
nuclear glucocorticoid receptor binding Binding to a nuclear glucocorticoid receptor.
protein domain specific binding Binding to a specific domain of a protein.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

5 GO annotations of biological process

Name Definition
ectodermal cell fate commitment The cell differentiation process that results in commitment of a cell to become part of the ectoderm.
mesoderm development The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
primitive streak formation The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

39 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KIC2 ETV1 ETS translocation variant 1 Bos taurus (Bovine) SS
A1A4L6 ETS2 Protein C-ets-2 Bos taurus (Bovine) SS
P15062 ETS1 Transforming protein p68/c-ets-1 Gallus gallus (Chicken) SS
Q90837 ERG Transcriptional regulator Erg Gallus gallus (Chicken) SS
P10157 ETS2 Protein C-ets-2 Gallus gallus (Chicken) SS
A2T762 ETV3 ETS translocation variant 3 Pan troglodytes (Chimpanzee) PR
Q04688 Ets97D DNA-binding protein Ets97D Drosophila melanogaster (Fruit fly) PR
P50548 ERF ETS domain-containing transcription factor ERF Homo sapiens (Human) PR
P41970 ELK3 ETS domain-containing protein Elk-3 Homo sapiens (Human) SS
P41161 ETV5 ETS translocation variant 5 Homo sapiens (Human) SS
P43268 ETV4 ETS translocation variant 4 Homo sapiens (Human) EV
Q06546 GABPA GA-binding protein alpha chain Homo sapiens (Human) SS
P28324 ELK4 ETS domain-containing protein Elk-4 Homo sapiens (Human) EV
P41162 ETV3 ETS translocation variant 3 Homo sapiens (Human) PR
P14921 ETS1 Protein C-ets-1 Homo sapiens (Human) EV
P50549 ETV1 ETS translocation variant 1 Homo sapiens (Human) EV
P11308 ERG Transcriptional regulator ERG Homo sapiens (Human) EV
P19419 ELK1 ETS domain-containing protein Elk-1 Homo sapiens (Human) EV
P15036 ETS2 Protein C-ets-2 Homo sapiens (Human) EV
P41158 Elk4 ETS domain-containing protein Elk-4 Mus musculus (Mouse) PR
P41164 Etv1 ETS translocation variant 1 Mus musculus (Mouse) SS
P41969 Elk1 ETS domain-containing protein Elk-1 Mus musculus (Mouse) PR
P41971 Elk3 ETS domain-containing protein Elk-3 Mus musculus (Mouse) EV
Q00422 Gabpa GA-binding protein alpha chain Mus musculus (Mouse) EV
Q9CXC9 Etv5 ETS translocation variant 5 Mus musculus (Mouse) SS
P97360 Etv6 Transcription factor ETV6 Mus musculus (Mouse) EV
Q8VDK3 Elf5 ETS-related transcription factor Elf-5 Mus musculus (Mouse) SS
Q60775 Elf1 ETS-related transcription factor Elf-1 Mus musculus (Mouse) PR
Q9Z2U4 Elf4 ETS-related transcription factor Elf-4 Mus musculus (Mouse) PR
Q9JHC9 Elf2 ETS-related transcription factor Elf-2 Mus musculus (Mouse) PR
Q9WTP3 Spdef SAM pointed domain-containing Ets transcription factor Mus musculus (Mouse) PR
P70459 Erf ETS domain-containing transcription factor ERF Mus musculus (Mouse) PR
P81270 Erg Transcriptional regulator ERG Mus musculus (Mouse) SS
P28322 Etv4 ETS translocation variant 4 Mus musculus (Mouse) SS
P27577 Ets1 Protein C-ets-1 Mus musculus (Mouse) EV
P41156 Ets1 Protein C-ets-1 Rattus norvegicus (Rat) SS
A4GTP4 Elk1 ETS domain-containing protein Elk-1 Rattus norvegicus (Rat) PR
Q9PUQ1 etv4 ETS translocation variant 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
A3FEM2 fev Protein FEV Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MNDFGIKNMD QVAPVANSFR GTLKRQPAFD TFDGSLFAVL PSLSEDQTLQ EVPTGLDSVS
70 80 90 100 110 120
HDSASCELPL LTPCSKAVMS QALKATFSGF QKEQRRLGIP KNPWLWSEQQ VCQWLLWATN
130 140 150 160 170 180
EFSLVNVNLH QFGMNGQMLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKTEDQYEE
190 200 210 220 230 240
NSHLNAVPHW INSNTLGFSM EQAPYGMQAP NYPKDNLLDS MCPPSATPAA LGSELQMLPK
250 260 270 280 290 300
SRLNTVNVNY CSISQDFPSS NVNLLNNNSG KPKDHDSPEN GGDSFESSDS LLRSWNSQSS
310 320 330 340 350 360
LLDVQRVPSF ESFEEDCSQS LCLSKLTMSF KDYIQERSDP VEQGKPVIPA AVLAGFTGSG
370 380 390 400 410 420
PIQLWQFLLE LLSDKSCQSF ISWTGDGWEF KLADPDEVAR RWGKRKNKPK MNYEKLSRGL
430 440 450 460
RYYYDKNIIH KTSGKRYVYR FVCDLQNLLG FTPEELHAIL GVQPDTED