AiPD: Autoinhibited Protein Database

P15036

Gene name	ETS2
Protein name	Protein C-ets-2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2114
EC number
Protein Class	ETS (PTHR11849)

Descriptions

ETS2 is a member of the Ets family of DNA binding transcription factors. It is subject to multiple levels of regulation of their DNA binding and transactivation properties. ETS2 autoinhibition is mediated by the packing of helices within the N-terminal inhibitory domain and C-terminal inhibitory domain onto helix H1 of the ETS domain.

Autoinhibitory domains (AIDs)

Target domain	359-439 (Helix H1 of ETS domain)
Relief mechanism	Others
Assay	Deletion assay, Structural analysis

AID

290-358 (N-terminal inhibitory region)

Target domain

359-439 (Helix H1 of ETS domain)

Relief mechanism

Others (Cooperative binding to Ets binding site)

Assay

Deletion assay, Structural analysis

Target domain	359-439 (Helix H1 of ETS domain)
Relief mechanism	Others
Assay	Deletion assay, Structural analysis

AID

440-469 (C-terminal inhibitory region)

Target domain

359-439 (Helix H1 of ETS domain)

Relief mechanism

Others (Cooperative binding to Ets binding site)

Assay

Deletion assay, Structural analysis

Accessory elements

No accessory elements

References

Newman JA et al. (2015) "Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2", The Journal of biological chemistry, 290, 8539-49

Basuyaux JP et al. (1997) "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner", The Journal of biological chemistry, 272, 26188-95

Autoinhibited structure

Activated structure

3 structures for P15036

Entry ID	Method	Resolution	Chain	Position	Source
4BQA	X-ray	250 A	A/D/G	325-464	PDB
4MHV	X-ray	245 A	A/B	76-170	PDB
AF-P15036-F1	Predicted				AlphaFoldDB

281 variants for P15036

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs915550106 CA320507422	5	G>R		No	ClinGen TOPMed gnomAD
CA10025372 rs756583173	8	N>I		No	ClinGen ExAC TOPMed gnomAD
CA10025374 rs115148137	15	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs115148137 CA10025375	15	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10025376 rs779037031	16	A>D		No	ClinGen ExAC TOPMed gnomAD
CA10025377 rs745988316	17	N>H		No	ClinGen ExAC gnomAD
CA10025378 rs150592938	17	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA320507437 rs908247678	18	S>G		No	ClinGen TOPMed
CA10025406 rs139909964	25	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs771933020 CA10025407	25	R>H		No	ClinGen ExAC TOPMed gnomAD
CA10025408 rs143407258	27	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA409943053 rs143407258	27	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA409943060 rs1288008218	28	A>V		No	ClinGen TOPMed
rs995949573 CA320508506	31	T>N		No	ClinGen Ensembl
CA409943098 rs1375831059	34	G>R		No	ClinGen gnomAD
rs1204664395 CA409943107	35	S>Y		No	ClinGen gnomAD
rs1466435861 CA409943113	36	L>P		No	ClinGen gnomAD
rs754290340 CA10025412	38	A>P		No	ClinGen ExAC TOPMed gnomAD
CA320508521 rs1001125602	39	V>D		No	ClinGen TOPMed gnomAD
CA409943163 rs1362016995	44	N>I		No	ClinGen TOPMed gnomAD
rs1362016995 CA409943162	44	N>S		No	ClinGen TOPMed gnomAD
CA409943169 rs1282333788	45	E>G		No	ClinGen gnomAD
CA409943178 rs1452924036	46	E>G		No	ClinGen gnomAD
CA320508529 rs1050170011	47	Q>E		No	ClinGen Ensembl
rs758609091 CA10025417	51	E>Q		No	ClinGen ExAC gnomAD
rs1438333285 CA409943281	56	L>V		No	ClinGen gnomAD
CA320508537 rs868010226	58	S>F		No	ClinGen Ensembl
rs1430466105 CA409943336	60	S>C		No	ClinGen TOPMed
rs1324799279 CA409943346	61	H>R		No	ClinGen TOPMed gnomAD
rs780267734 CA10025418	62	D>N		No	ClinGen ExAC gnomAD
rs1280673132 CA409943885	63	S>F		No	ClinGen gnomAD
RCV000968784 rs34373350 CA10025437	64	A>T		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10025439 rs781489122	65	N>K		No	ClinGen ExAC gnomAD
rs755229059 CA10025438	65	N>S		No	ClinGen ExAC gnomAD
CA409943953 rs1205833064	68	L>F		No	ClinGen gnomAD
CA10025441 rs756017903	69	P>L		No	ClinGen ExAC TOPMed gnomAD
CA10025442 rs777697990	73	P>L		No	ClinGen ExAC TOPMed gnomAD
CA409944032 rs1187443602	74	C>G		No	ClinGen TOPMed
rs539702108 CA10025445	79	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409944153 rs1353159322	82	A>V		No	ClinGen gnomAD
CA10025447 rs144867115	88	S>R		No	ClinGen ESP ExAC TOPMed
rs114481523 CA10025448	91	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10025450 rs149038175	95	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs760122401 CA10025449	95	R>W		No	ClinGen ExAC TOPMed gnomAD
rs930149085 CA320508930	96	R>C		No	ClinGen gnomAD
rs535308565 CA10025451	96	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs535308565 CA10025452	96	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1447801871 CA409944383	98	G>C		No	ClinGen TOPMed gnomAD
CA10025453 rs766816665	98	G>D		No	ClinGen ExAC gnomAD
rs1341661839 CA409944430	101	K>N		No	ClinGen gnomAD
rs752915999 CA10025475	102	N>K		No	ClinGen ExAC gnomAD
CA409944505 rs767881783	102	N>S		No	ClinGen ExAC gnomAD
rs767881783 CA10025474	102	N>T		No	ClinGen ExAC gnomAD
CA409944623 rs1426522494	110	Q>H		No	ClinGen TOPMed gnomAD
rs760783079 CA10025476	112	C>G		No	ClinGen ExAC gnomAD
CA409944688 rs1227099494	114	W>*		No	ClinGen gnomAD
rs753854772 CA10025478	115	L>F		No	ClinGen ExAC TOPMed gnomAD
rs78391361 CA10025479	116	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs78391361 CA10025480	116	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA10025482 rs758150519	117	W>S		No	ClinGen ExAC
CA409944734 rs1374696251	118	A>S		No	ClinGen TOPMed
rs746724832 CA10025484	119	T>P		No	ClinGen ExAC
CA409944743 rs780811710	120	N>D		No	ClinGen ExAC gnomAD
CA10025486 rs780811710	120	N>H		No	ClinGen ExAC gnomAD
CA10025487 rs201321686	120	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1267005843 CA409944768	123	S>N		No	ClinGen gnomAD
rs774957702 CA10025489	125	V>E		No	ClinGen ExAC
rs773376571 CA409944789	126	N>K		No	ClinGen ExAC TOPMed gnomAD
rs772611992 CA10025491	127	V>M		No	ClinGen ExAC TOPMed gnomAD
CA10025492 rs775683010	128	N>H		No	ClinGen ExAC gnomAD
rs775683010 CA10025493	128	N>Y		No	ClinGen ExAC gnomAD
CA10025494 rs764212435	130	Q>R		No	ClinGen ExAC gnomAD
CA409944820 rs776789283	131	R>S		No	ClinGen ExAC gnomAD
CA10025496 rs761816863	132	F>I		No	ClinGen ExAC gnomAD
CA10025498 rs201897945	133	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1417359876 CA409944861	137	Q>R		No	ClinGen TOPMed
CA320509148 rs996382296	138	M>I		No	ClinGen TOPMed
CA409944866 rs1392590037	138	M>L		No	ClinGen gnomAD
CA10025502 rs754672212	140	C>Y		No	ClinGen ExAC gnomAD
CA10025503 rs780641610	143	G>S		No	ClinGen ExAC gnomAD
rs888988500 CA320509165	143	G>V		No	ClinGen Ensembl
rs1803557 CA320509166	145	E>V		No	ClinGen Ensembl
rs755635528 COSM3713443 COSM3713442 CA10025505	146	R>C	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA409944919 rs1350625148	146	R>H		No	ClinGen TOPMed gnomAD
rs1229721854 CA409944932	148	L>Q		No	ClinGen gnomAD
CA10025509 rs147754962	150	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10025510 rs747282020	151	A>T		No	ClinGen ExAC gnomAD
rs142517222 CA10025511	154	F>L		No	ClinGen ESP ExAC
CA10025512 rs776679730	167	I>N		No	ClinGen ExAC gnomAD
CA10025528 rs747434496	172	E>D		No	ClinGen ExAC gnomAD
rs1195681924 CA409945335	174	T>R		No	ClinGen TOPMed
CA409945349 rs1433767109	176	D>G		No	ClinGen gnomAD
CA409945345 rs1176734752	176	D>N		No	ClinGen TOPMed
rs768857570 CA10025530	178	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA409945380 rs1273946656	180	E>G		No	ClinGen gnomAD
CA409945394 rs1326047456	182	S>A		No	ClinGen TOPMed
CA409945397 rs1344734147	182	S>L		No	ClinGen gnomAD
CA409945419 rs1229446249	186	S>P		No	ClinGen TOPMed gnomAD
CA409945425 rs372145357	187	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA10025532 rs372145357	187	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1271400216 CA409945439	189	H>R		No	ClinGen TOPMed
rs1324322890 CA409945465	192	N>K		No	ClinGen gnomAD
CA409945470 rs1433831363	193	S>N		No	ClinGen TOPMed gnomAD
CA409945484 rs1343317130	195	T>A		No	ClinGen gnomAD
rs772028653 CA10025557	197	G>D		No	ClinGen ExAC gnomAD
rs769999489 CA10025534	197	G>S		No	ClinGen ExAC gnomAD
rs369614292 CA320510402	201	E>D		No	ClinGen ESP gnomAD
rs775434582 CA409945985	203	A>E		No	ClinGen ExAC TOPMed gnomAD
rs775434582 CA10025558	203	A>V		No	ClinGen ExAC TOPMed gnomAD
CA409946001 rs1409520740	204	P>L		No	ClinGen gnomAD
rs763874169 CA10025560	205	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs763874169 CA320510408	205	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA320510421 rs981053782	207	M>I		No	ClinGen gnomAD
CA320510411 rs969951821	207	M>T		No	ClinGen gnomAD
CA409946075 rs1387898672	209	T>I		No	ClinGen gnomAD
rs1601430715 CA409946118	212	Y>S		No	ClinGen Ensembl
rs753494319 CA10025562	213	P>A		No	ClinGen ExAC TOPMed gnomAD
CA10025561 rs753494319	213	P>S		No	ClinGen ExAC TOPMed gnomAD
CA10025565 rs755496148	214	K>E		No	ClinGen ExAC gnomAD
rs552586832 CA10025566	214	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409946154 rs1283977667	215	G>R		No	ClinGen TOPMed
rs1365789879 CA409946174	216	G>A		No	ClinGen TOPMed
CA10025568 rs115908228 COSM94254	216	G>S	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs61735785 RCV000961092 CA10025569	217	L>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs114460001 CA10025570	218	L>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771176252 CA10025571	219	D>G		No	ClinGen ExAC gnomAD
CA409946261 rs1182274965	221	M>I		No	ClinGen gnomAD
CA10025572 rs778912960	221	M>V		No	ClinGen ExAC gnomAD
CA10025573 rs115297166	222	C>F		No	ClinGen 1000Genomes ExAC gnomAD
CA10025575 rs114562289	223	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA409946283 rs771905336	223	P>S		No	ClinGen ExAC gnomAD
rs771905336 CA10025574	223	P>T		No	ClinGen ExAC gnomAD
COSM371865 rs1349030537 CA409946298	224	A>S	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA409946347 rs1457151046	228	S>G		No	ClinGen TOPMed
CA409946353 rs1601430826	228	S>I		No	ClinGen Ensembl
rs577157851 CA10025578	229	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10025579 rs577157851	229	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA320510465 rs372641031	230	L>F		No	ClinGen ESP gnomAD
CA409946376 rs1358536335	230	L>P		No	ClinGen gnomAD
CA10025580 rs764929763	232	S>F		No	ClinGen ExAC gnomAD
CA409946412 rs1476307789	233	E>G		No	ClinGen TOPMed
CA10025581 rs539828835	233	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs558527007 CA10025582	234	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371568403 CA409946429	235	E>K		No	ClinGen TOPMed
rs371568403 CA320510477	235	E>Q		No	ClinGen TOPMed
CA320510485 rs777554249	238	M>I		No	ClinGen TOPMed gnomAD
rs755992789 CA320510482	238	M>R		No	ClinGen Ensembl
rs753252691 CA10025584	240	P>R		No	ClinGen ExAC gnomAD
CA409946511 rs1264878812	240	P>S		No	ClinGen TOPMed
CA320510496 rs1024159376	243	R>Q		No	ClinGen TOPMed gnomAD
CA10025585 rs150430243	243	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs764505333 CA10025586	246	S>F		No	ClinGen ExAC gnomAD
CA10025587 rs138127643	247	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs116698978 CA10025589	249	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10025590 rs745969118	251	Y>C		No	ClinGen ExAC gnomAD
CA409946707 rs1471504426	255	S>T		No	ClinGen gnomAD
CA409946737 rs1165873704	257	D>N		No	ClinGen TOPMed gnomAD
rs1388690974 CA409946796	261	S>G		No	ClinGen gnomAD
CA10025592 rs780262985	262	N>S		No	ClinGen ExAC gnomAD
CA10025594 rs768711199	264	N>S		No	ClinGen ExAC TOPMed gnomAD
CA409946886 rs1445946373	268	N>D		No	ClinGen gnomAD
CA10025595 rs776625757	270	S>T		No	ClinGen ExAC gnomAD
CA409947034 rs1365417546	271	G>E		No	ClinGen gnomAD
rs1224272595 CA409947038	272	T>A		No	ClinGen TOPMed
rs747916912 CA10025613	272	T>I		No	ClinGen ExAC TOPMed gnomAD
rs770553759 CA10025617	273	P>L		No	ClinGen ExAC gnomAD
CA10025616 rs749006471	273	P>T		No	ClinGen ExAC gnomAD
CA409947047 rs1465040434	274	K>E		No	ClinGen gnomAD
CA10025619 rs758977569	276	H>R		No	ClinGen ExAC TOPMed gnomAD
COSM3841909 rs777149491 COSM3841910 CA10025621	277	D>N	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA10025622 rs762206299	279	P>L		No	ClinGen ExAC gnomAD
rs750752505 CA10025624	282	G>S		No	ClinGen ExAC TOPMed gnomAD
rs138783369 CA10025625	283	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA409947160 rs1320107796	284	D>N		No	ClinGen gnomAD
rs755069743 CA10025628	287	E>K		No	ClinGen ExAC TOPMed gnomAD
rs755069743 CA409947209	287	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA320510900 rs1042607818	288	S>N		No	ClinGen Ensembl
CA409947266 rs1347273131	291	S>T		No	ClinGen gnomAD
rs781109403 CA10025629	293	L>P		No	ClinGen ExAC gnomAD
rs752718830 CA10025630	297	N>T		No	ClinGen ExAC gnomAD
rs146230611 CA10025631	299	Q>P		No	ClinGen ESP ExAC gnomAD
rs1245886108 CA409947404	300	S>L		No	ClinGen TOPMed
CA10025634 rs568367551	303	L>M		No	ClinGen 1000Genomes ExAC gnomAD
CA10025636 rs745401875	305	V>M		No	ClinGen ExAC TOPMed gnomAD
rs536810041 CA320510916	307	R>Q		No	ClinGen 1000Genomes gnomAD
rs771664787 CA10025637	307	R>W		No	ClinGen ExAC gnomAD
rs1411415689 CA409947949	312	E>K		No	ClinGen gnomAD
CA10025640 rs201065633	314	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA409947974 rs1365991432	315	E>G		No	ClinGen TOPMed
rs904004816 CA320510920	315	E>K		No	ClinGen Ensembl
rs1274652900 CA409947981	316	D>Y		No	ClinGen TOPMed
CA409947997 rs1323927458	318	C>G		No	ClinGen TOPMed gnomAD
CA409947996 rs1323927458	318	C>R		No	ClinGen TOPMed gnomAD
CA409948000 rs1367378551	318	C>S		No	ClinGen gnomAD
CA10025641 rs773640332	319	S>I		No	ClinGen ExAC gnomAD
rs1407862810 CA409948017	320	Q>H		No	ClinGen gnomAD
CA320510946 rs201705823	322	L>V		No	ClinGen Ensembl
rs1001566013 CA320510948	324	L>F		No	ClinGen Ensembl
rs763343892 CA10025642	325	N>S		No	ClinGen ExAC gnomAD
CA10025643 rs766741634	328	T>I		No	ClinGen ExAC TOPMed gnomAD
CA320510954 rs377345933	328	T>S		No	ClinGen ESP TOPMed gnomAD
rs759798841 CA10025645	329	M>K		No	ClinGen ExAC gnomAD
rs751784308 CA10025644	329	M>V		No	ClinGen ExAC TOPMed gnomAD
CA320510983 rs1028567707	332	K>Q		No	ClinGen Ensembl
CA409948091 rs1412382425	332	K>R		No	ClinGen TOPMed
rs1228112481 CA409948115	335	I>S		No	ClinGen gnomAD
rs767702107 CA10025646	338	R>T		No	ClinGen ExAC gnomAD
CA10025648 rs756087792	339	S>N		No	ClinGen ExAC TOPMed gnomAD
CA409948155 rs1451033653	340	D>E		No	ClinGen TOPMed
CA409948152 rs1251221942	340	D>G		No	ClinGen gnomAD
rs139305338 CA10025649	341	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1472555746 CA409948164	342	V>A		No	ClinGen gnomAD
rs756993602 CA10025651	342	V>M		No	ClinGen ExAC TOPMed gnomAD
rs545879938 CA320511001	343	E>Q		No	ClinGen 1000Genomes
CA409948177 rs1466262358	344	Q>R		No	ClinGen TOPMed gnomAD
rs1601431813 CA409948198	347	P>Q		No	ClinGen Ensembl
CA409948215 rs772140972	350	P>S		No	ClinGen TOPMed gnomAD
CA320511006 rs772140972	350	P>T		No	ClinGen TOPMed gnomAD
CA409948219 rs1386846953	351	A>T		No	ClinGen gnomAD
rs116771448 CA10025652	353	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409948241 rs1167852113	355	A>T		No	ClinGen gnomAD
CA10025655 rs757163141	356	G>R		No	ClinGen ExAC TOPMed gnomAD
CA10025654 rs757163141	356	G>S		No	ClinGen ExAC TOPMed gnomAD
rs746447739 CA10025656	358	T>A		No	ClinGen ExAC gnomAD
CA320511813 rs1040273379	359	G>E		No	ClinGen TOPMed
CA409948264 rs1569025991	359	G>R		No	ClinGen Ensembl
CA409948326 rs1262150746	366	W>L		No	ClinGen gnomAD
CA320511826 rs535614049	377	S>C		No	ClinGen Ensembl
CA409948398 rs1480489542	377	S>P		No	ClinGen gnomAD
rs764200775 CA10025683	378	C>S		No	ClinGen ExAC gnomAD
rs776691299 CA409948415	379	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs761800465 CA10025685	382	I>T		No	ClinGen ExAC gnomAD
CA409948450 rs1465836920	384	W>L		No	ClinGen gnomAD
CA10025688 rs758089939	388	G>E		No	ClinGen ExAC TOPMed gnomAD
rs116387099 CA10025687	388	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1601433127 CA409948485	389	W>*		No	ClinGen Ensembl
CA10025691 rs754652236	394	A>T		No	ClinGen ExAC TOPMed gnomAD
CA409948527 rs1228007843	395	D>E		No	ClinGen TOPMed gnomAD
rs115880316 CA320511859	395	D>N		No	ClinGen 1000Genomes TOPMed gnomAD
CA409948543 rs1601433167	398	E>K		No	ClinGen Ensembl
rs1331422908 CA409948567	399	V>A		No	ClinGen TOPMed
rs1331422908 CA409948568	399	V>G		No	ClinGen TOPMed
rs1601433852 CA409948570	400	A>P		No	ClinGen Ensembl
rs1389242494 CA409948575 COSM1414074 COSM1414075	401	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
COSM1251536 COSM1251535 rs1252271782 CA409948578	401	R>H	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs762726949 CA320512273	402	R>Q		No	ClinGen gnomAD
rs1421624560 CA409948582	402	R>W		No	ClinGen TOPMed gnomAD
rs200586471 CA320512276	410	P>L		No	ClinGen 1000Genomes
CA10025712 rs777392517 COSM1534698 COSM1534699	411	K>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA320512308 rs914709352	426	D>N		No	ClinGen TOPMed
CA10025719 rs376004538	433	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA409948808 rs1365534454	433	T>S		No	ClinGen TOPMed
rs769911963 CA10025721	434	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1470009589 COSM236734 CA409948832	437	R>C	prostate [Cosmic]	No	ClinGen cosmic curated TOPMed
COSM176132 CA10025724 rs762854102	437	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA409948843 rs1482108080	439	V>M		No	ClinGen gnomAD
CA409948858 rs1180885980	441	R>C		No	ClinGen gnomAD
rs1242969238 CA409948862	441	R>L		No	ClinGen gnomAD
rs558667507 CA320512330	443	V>M		No	ClinGen 1000Genomes
CA409948890 rs1185768997	445	D>E		No	ClinGen gnomAD
rs1310195239 CA409948885	445	D>N		No	ClinGen gnomAD
rs774020003 CA10025726	447	Q>R		No	ClinGen ExAC gnomAD
rs908656630 CA320512352	450	L>M		No	ClinGen TOPMed
CA320512359 rs997447535	453	T>M		No	ClinGen TOPMed
CA10025728 rs767296660	454	P>A		No	ClinGen ExAC gnomAD
rs1601434046 CA409948948	455	E>K		No	ClinGen Ensembl
rs147744979 CA320512366	456	E>K		No	ClinGen ESP
rs753377257 CA409948975	458	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA409948976 rs1442441699	459	A>T		No	ClinGen TOPMed
CA409948981 rs1347801283	459	A>V		No	ClinGen TOPMed
CA10025733 rs142665354	462	G>S		No	ClinGen ExAC TOPMed gnomAD
CA10025734 rs766845683	463	V>A		No	ClinGen ExAC gnomAD
CA409948999 rs1361203764	463	V>I		No	ClinGen gnomAD
CA409949010 rs1601434097	464	Q>H		No	ClinGen Ensembl
rs1206754324 CA409949012	465	P>T		No	ClinGen gnomAD
rs1016137301 CA320512405	466	D>E		No	ClinGen Ensembl
CA320512403 rs1005358178	466	D>N		No	ClinGen TOPMed gnomAD
rs1202427968 CA409949022	466	D>V		No	ClinGen gnomAD
CA409949027 rs1263407730	467	T>M		No	ClinGen gnomAD
CA409949038 rs1192553759	469	D>N		No	ClinGen gnomAD
CA409949043 rs1439045774	469	D>V		No	ClinGen TOPMed

No associated diseases with P15036

3 regional properties for P15036

Type	Name	Position	InterPro Accession
domain	Ets domain	362 - 447	IPR000418
domain	Pointed domain	85 - 170	IPR003118
domain	Ets1, N-terminal flanking region of Ets domain	273 - 359	IPR045688

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family	PTHR11849	ETS
PANTHER Subfamily	PTHR11849:SF188	PROTEIN C-ETS-2
PANTHER Protein Class	DNA-binding transcription factor helix-turn-helix transcription factor winged helix/forkhead transcription factor
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

8 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
protein domain specific binding	Binding to a specific domain of a protein.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II-specific DNA-binding transcription factor binding	Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

8 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
ectodermal cell fate commitment	The cell differentiation process that results in commitment of a cell to become part of the ectoderm.
mesoderm development	The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
primitive streak formation	The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
skeletal system development	The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

40 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2KIC2	ETV1	ETS translocation variant 1	Bos taurus (Bovine)	SS
A1A4L6	ETS2	Protein C-ets-2	Bos taurus (Bovine)	SS
P15062	ETS1	Transforming protein p68/c-ets-1	Gallus gallus (Chicken)	SS
Q90837	ERG	Transcriptional regulator Erg	Gallus gallus (Chicken)	SS
P10157	ETS2	Protein C-ets-2	Gallus gallus (Chicken)	SS
A2T762	ETV3	ETS translocation variant 3	Pan troglodytes (Chimpanzee)	PR
Q04688	Ets97D	DNA-binding protein Ets97D	Drosophila melanogaster (Fruit fly)	PR
P41970	ELK3	ETS domain-containing protein Elk-3	Homo sapiens (Human)	SS
Q06546	GABPA	GA-binding protein alpha chain	Homo sapiens (Human)	SS
Q9Y603	ETV7	Transcription factor ETV7	Homo sapiens (Human)	SS
P41212	ETV6	Transcription factor ETV6	Homo sapiens (Human)	SS
P78545	ELF3	ETS-related transcription factor Elf-3	Homo sapiens (Human)	SS
Q9UKW6	ELF5	ETS-related transcription factor Elf-5	Homo sapiens (Human)	EV
P32519	ELF1	ETS-related transcription factor Elf-1	Homo sapiens (Human)	PR
Q99607	ELF4	ETS-related transcription factor Elf-4	Homo sapiens (Human)	PR
O95238	SPDEF	SAM pointed domain-containing Ets transcription factor	Homo sapiens (Human)	PR
P50548	ERF	ETS domain-containing transcription factor ERF	Homo sapiens (Human)	PR
P41162	ETV3	ETS translocation variant 3	Homo sapiens (Human)	PR
P11308	ERG	Transcriptional regulator ERG	Homo sapiens (Human)	EV
P43268	ETV4	ETS translocation variant 4	Homo sapiens (Human)	EV
P41161	ETV5	ETS translocation variant 5	Homo sapiens (Human)	SS
P50549	ETV1	ETS translocation variant 1	Homo sapiens (Human)	EV
P28324	ELK4	ETS domain-containing protein Elk-4	Homo sapiens (Human)	EV
P19419	ELK1	ETS domain-containing protein Elk-1	Homo sapiens (Human)	EV
P14921	ETS1	Protein C-ets-1	Homo sapiens (Human)	EV
P41971	Elk3	ETS domain-containing protein Elk-3	Mus musculus (Mouse)	EV
Q00422	Gabpa	GA-binding protein alpha chain	Mus musculus (Mouse)	EV
P41969	Elk1	ETS domain-containing protein Elk-1	Mus musculus (Mouse)	PR
P28322	Etv4	ETS translocation variant 4	Mus musculus (Mouse)	SS
P27577	Ets1	Protein C-ets-1	Mus musculus (Mouse)	EV
P70459	Erf	ETS domain-containing transcription factor ERF	Mus musculus (Mouse)	PR
Q9CXC9	Etv5	ETS translocation variant 5	Mus musculus (Mouse)	SS
P41158	Elk4	ETS domain-containing protein Elk-4	Mus musculus (Mouse)	PR
P41164	Etv1	ETS translocation variant 1	Mus musculus (Mouse)	SS
P81270	Erg	Transcriptional regulator ERG	Mus musculus (Mouse)	SS
P15037	Ets2	Protein C-ets-2	Mus musculus (Mouse)	SS
P41156	Ets1	Protein C-ets-1	Rattus norvegicus (Rat)	SS
A4GTP4	Elk1	ETS domain-containing protein Elk-1	Rattus norvegicus (Rat)	PR
Q9PUQ1	etv4	ETS translocation variant 4	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
A3FEM2	fev	Protein FEV	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MNDFGIKNMD	QVAPVANSYR	GTLKRQPAFD	TFDGSLFAVF	PSLNEEQTLQ	EVPTGLDSIS
70	80	90	100	110	120
HDSANCELPL	LTPCSKAVMS	QALKATFSGF	KKEQRRLGIP	KNPWLWSEQQ	VCQWLLWATN
130	140	150	160	170	180
EFSLVNVNLQ	RFGMNGQMLC	NLGKERFLEL	APDFVGDILW	EHLEQMIKEN	QEKTEDQYEE
190	200	210	220	230	240
NSHLTSVPHW	INSNTLGFGT	EQAPYGMQTQ	NYPKGGLLDS	MCPASTPSVL	SSEQEFQMFP
250	260	270	280	290	300
KSRLSSVSVT	YCSVSQDFPG	SNLNLLTNNS	GTPKDHDSPE	NGADSFESSD	SLLQSWNSQS
310	320	330	340	350	360
SLLDVQRVPS	FESFEDDCSQ	SLCLNKPTMS	FKDYIQERSD	PVEQGKPVIP	AAVLAGFTGS
370	380	390	400	410	420
GPIQLWQFLL	ELLSDKSCQS	FISWTGDGWE	FKLADPDEVA	RRWGKRKNKP	KMNYEKLSRG
430	440	450	460
LRYYYDKNII	HKTSGKRYVY	RFVCDLQNLL	GFTPEELHAI	LGVQPDTED