AiPD: Autoinhibited Protein Database

P13861

Gene name	PRKAR2A (PKR2, PRKAR2)
Protein name	cAMP-dependent protein kinase type II-alpha regulatory subunit
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5576
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

18-138 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

18-138 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for P13861

Entry ID	Method	Resolution	Chain	Position	Source
2IZX	X-ray	130 A	A/B	4-44	PDB
2KYG	NMR	-	A/B	1-45	PDB
4ZP3	X-ray	263 A	A/B/C/D/E/F/G/H/I/J/K/L	2-44	PDB
5H78	X-ray	200 A	A/B	5-49	PDB
5XBY	X-ray	325 A	A/B/C/D	5-44	PDB
AF-P13861-F1	Predicted				AlphaFoldDB

303 variants for P13861

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1412304377 CA352999207	4	I>L		No	ClinGen gnomAD
CA352999198 rs1559659535	5	Q>*		No	ClinGen Ensembl
rs375699448 CA2387228	5	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs750807469 CA352999187	6	I>M		No	ClinGen ExAC TOPMed gnomAD
CA352999175 rs1200218187	8	P>L		No	ClinGen gnomAD
CA352999173 rs1453787015	9	G>R		No	ClinGen gnomAD
CA352999166 rs1204674286	10	L>F		No	ClinGen TOPMed gnomAD
rs1204674286 CA352999167	10	L>V		No	ClinGen TOPMed gnomAD
rs570925103 CA2387224	11	T>K		No	ClinGen 1000Genomes ExAC gnomAD
CA352999141 rs1221910832	14	L>P		No	ClinGen gnomAD
CA2387223 rs755814366	15	Q>H		No	ClinGen ExAC gnomAD
rs1333004031 CA352999095	21	V>A		No	ClinGen gnomAD
CA74209872 rs973354419	21	V>L		No	ClinGen TOPMed gnomAD
CA352999098 rs973354419	21	V>M		No	ClinGen TOPMed gnomAD
rs34715183 CA74209857	22	L>M		No	ClinGen Ensembl
rs767096709 CA2387221	22	L>R		No	ClinGen ExAC gnomAD
CA352999086 rs1466484501	23	R>L		No	ClinGen TOPMed
CA352999084 rs759540303	24	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA2387220 rs759540303	24	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs759540303 CA352999085	24	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA2387219 rs774485621	24	Q>R		No	ClinGen ExAC gnomAD
CA2387218 rs766432145	27	P>H		No	ClinGen ExAC TOPMed gnomAD
CA74209834 rs987570661	30	V>I		No	ClinGen TOPMed gnomAD
CA74209829 rs923733922	32	F>I		No	ClinGen Ensembl
CA2387215 rs769854491	33	A>S		No	ClinGen ExAC gnomAD
rs1193088664 CA352999018	34	V>A		No	ClinGen gnomAD
rs979145990 CA74209821	34	V>M		No	ClinGen gnomAD
rs1202019341 CA352998994	37	F>L		No	ClinGen TOPMed gnomAD
CA2387214 rs748448191	38	T>P		No	ClinGen ExAC gnomAD
rs1403941344 CA352998981	40	L>M		No	ClinGen Ensembl
CA352998973 rs1277688995	41	R>L		No	ClinGen gnomAD
rs768785168 CA2387212	42	E>K		No	ClinGen ExAC
CA2387211 rs747107238	43	A>D		No	ClinGen ExAC TOPMed gnomAD
CA74209809 rs967770390	43	A>T		No	ClinGen gnomAD
CA352998954 rs1575971919	44	R>L		No	ClinGen Ensembl
rs550045306 CA74209779	45	A>V		No	ClinGen 1000Genomes
rs1365311892 CA352998943	46	P>L		No	ClinGen gnomAD
CA74209776 rs916215824	47	A>V		No	ClinGen TOPMed
rs955416633 CA74209773	48	S>L		No	ClinGen TOPMed
CA352998932 rs1321912939	49	V>F		No	ClinGen gnomAD
rs758938832 CA2387209	51	P>L		No	ClinGen ExAC TOPMed gnomAD
CA352998914 rs1404954295	52	A>T		No	ClinGen TOPMed gnomAD
rs181690449 CA2387208	53	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA74209768 rs997168850	53	A>V		No	ClinGen TOPMed gnomAD
rs779384345 CA2387207	54	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1167853048 CA352998890	56	R>L		No	ClinGen gnomAD
rs567753272 CA2387206	59	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2387205 rs752463301	60	G>D		No	ClinGen ExAC gnomAD
rs1181784306 CA352998859	61	H>L		No	ClinGen gnomAD
CA352998854 rs1444050942	62	P>S		No	ClinGen gnomAD
CA2387201 rs751119335	63	P>L		No	ClinGen ExAC TOPMed gnomAD
CA352998847 rs751119335	63	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA2387202 rs751119335	63	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1258496154 CA352998848	63	P>S		No	ClinGen TOPMed
rs766378877 CA2387197	64	P>S		No	ClinGen ExAC gnomAD
CA352998841 rs1471142223	65	E>K		No	ClinGen TOPMed
TCGA novel	65	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA352998832 rs1243207245	66	P>L		No	ClinGen TOPMed gnomAD
rs200759322 CA2387196	66	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA2387195 rs200759322	66	P>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1003045784 CA352998826	67	G>D		No	ClinGen TOPMed
rs1003045784 CA74209721	67	G>V		No	ClinGen TOPMed
rs1559658876 CA352998822	68	P>A		No	ClinGen Ensembl
CA2387194 rs372669481	68	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA2387192 rs776857083	69	D>H		No	ClinGen ExAC
rs1412394357 CA352998809	70	R>L		No	ClinGen TOPMed
CA2387190 rs747054161	72	A>S		No	ClinGen ExAC gnomAD
rs775569804 CA2387189	73	D>N		No	ClinGen ExAC gnomAD
rs772547535 CA352998787	74	A>P		No	ClinGen ExAC gnomAD
rs772547535 CA2387188	74	A>S		No	ClinGen ExAC gnomAD
rs1288824665 CA352998779	75	K>R		No	ClinGen TOPMed gnomAD
rs1041900140 CA74209683	76	G>R		No	ClinGen TOPMed
CA2387187 rs746428551	77	D>G		No	ClinGen ExAC gnomAD
CA2387186 rs779144009	78	S>R		No	ClinGen ExAC gnomAD
CA352998717 rs1408646126	80	S>*		No	ClinGen TOPMed
rs771382760 CA2387185	82	E>G		No	ClinGen ExAC gnomAD
rs1230995209 CA352998655	84	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2387184 rs749627616	84	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1468753114 CA352998663	84	E>V		No	ClinGen gnomAD
CA352998618 rs1483249104	87	E>A		No	ClinGen gnomAD
TCGA novel	88	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2387161 rs757982173	89	P>L		No	ClinGen ExAC gnomAD
CA352998032 rs1321477637	91	P>T		No	ClinGen gnomAD
CA352998026 rs1343213746	92	S>G		No	ClinGen TOPMed gnomAD
rs1231100218 CA352998016	93	R>K		No	ClinGen TOPMed
rs1231100218 CA352998015	93	R>T		No	ClinGen TOPMed
rs749908420 CA2387160	95	N>S		No	ClinGen ExAC TOPMed gnomAD
CA74197844 rs867755154	97	R>Q		No	ClinGen Ensembl
CA352997950 rs1575889078	101	C>S		No	ClinGen Ensembl
rs1426604649 CA352997931	104	T>A		No	ClinGen gnomAD
CA352997927 rs1389036041	104	T>I		No	ClinGen gnomAD
rs746644588 CA2387144	107	P>A		No	ClinGen ExAC gnomAD
rs746644588 CA352997909	107	P>S		No	ClinGen ExAC gnomAD
CA2387143 rs199867642	108	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	111	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA352997870 rs1258072720	112	E>G		No	ClinGen gnomAD
CA2387141 rs745337551	113	D>G		No	ClinGen ExAC TOPMed gnomAD
CA352997862 rs745337551	113	D>V		No	ClinGen ExAC TOPMed gnomAD
rs778340299 CA2387140	114	T>R		No	ClinGen ExAC TOPMed gnomAD
rs757188386 CA2387139	115	D>G		No	ClinGen ExAC TOPMed gnomAD
rs749291577 CA2387138	117	R>G		No	ClinGen ExAC gnomAD
CA2387120 rs770407130	118	V>G		No	ClinGen ExAC gnomAD
CA353001030 rs748812211	119	I>F		No	ClinGen ExAC gnomAD
CA353001027 rs1457938591	119	I>S		No	ClinGen gnomAD
CA2387119 rs748812211	119	I>V		No	ClinGen ExAC gnomAD
rs1156494668 CA353000999	123	T>S		No	ClinGen gnomAD
CA2387117 rs777619237	125	E>K		No	ClinGen ExAC gnomAD
rs879094305 CA74190744	129	R>S		No	ClinGen Ensembl
rs756075947 CA2387116	131	Q>E		No	ClinGen ExAC gnomAD
CA2387115 rs748291376	131	Q>P		No	ClinGen ExAC gnomAD
CA74190737 rs748291376	131	Q>R		No	ClinGen ExAC gnomAD
rs1266801625 CA353000942	132	E>K		No	ClinGen gnomAD
rs199498651 CA2387114	134	C>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779101322 CA74190720	136	D>G		No	ClinGen gnomAD
rs755192539 CA2387113	136	D>H		No	ClinGen ExAC TOPMed gnomAD
rs1048055263 CA74190713	144	D>E		No	ClinGen Ensembl
rs751791908 CA2387112	145	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs766465497 CA2387111	145	Q>R		No	ClinGen ExAC gnomAD
rs981554178 CA74188897	146	E>D		No	ClinGen TOPMed
rs746831162 CA2387093	146	E>K		No	ClinGen ExAC gnomAD
rs746831162 CA353000832	146	E>Q		No	ClinGen ExAC gnomAD
CA2387092 rs780071307	149	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1433947157 CA353000806	150	Q>E		No	ClinGen gnomAD
CA2387088 rs757835834	153	D>E		No	ClinGen ExAC gnomAD
CA2387089 rs560353945	153	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1468891944 CA353000773	155	M>K		No	ClinGen Ensembl
rs904524915 CA74188889	155	M>V		No	ClinGen gnomAD
CA353000759 rs1559617874	157	E>K		No	ClinGen Ensembl
rs1479261330 CA353000749	158	R>K		No	ClinGen TOPMed gnomAD
CA2387087 rs754364832	159	I>T		No	ClinGen ExAC gnomAD
CA353000743 rs1489021856	159	I>V		No	ClinGen TOPMed gnomAD
rs764678772 CA2387086	161	K>T		No	ClinGen ExAC gnomAD
CA2387085 rs760885038	163	D>A		No	ClinGen ExAC gnomAD
CA353000700 rs1575871937	165	H>L		No	ClinGen Ensembl
rs371959163 CA2387084	165	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs182210450 CA74188880	166	V>F		No	ClinGen 1000Genomes
rs1277585553 CA353000691	167	I>V		No	ClinGen TOPMed gnomAD
rs762639940 CA2387082	170	G>R		No	ClinGen ExAC gnomAD
rs1211439484 CA353000660	171	D>G		No	ClinGen gnomAD
CA353000656 rs1202992027	172	D>N		No	ClinGen TOPMed
CA74188874 rs1021610775	173	G>E		No	ClinGen Ensembl
CA2387079 rs577790327	178	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA353000600 rs1299368108	179	I>M		No	ClinGen gnomAD
CA353000605 rs1365286322	179	I>V		No	ClinGen gnomAD
TCGA novel	180	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1566739 rs201062271 CA2387078	181	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	185	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370852251 CA2387059	189	T>R		No	ClinGen ESP ExAC gnomAD
rs776234506 CA2387058	190	K>T		No	ClinGen ExAC gnomAD
rs1162724619 CA353000084	191	D>H		No	ClinGen TOPMed gnomAD
rs763917555 CA2387057	192	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1414859821 CA353000066	193	Q>P		No	ClinGen gnomAD
CA2387054 rs147886817	195	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2387053 rs199776610	195	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199776610 CA353000054	195	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2387055 rs147886817	195	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA74181611 rs936640994	197	V>I		No	ClinGen Ensembl
rs1181391783 CA353000042	198	G>S		No	ClinGen gnomAD
CA353000025 rs771219111	200	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA2387051 rs771219111	200	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1450520466 CA353000008	202	N>K		No	ClinGen gnomAD
rs925193841 CA74181592	202	N>S		No	ClinGen gnomAD
CA353000004 rs1290226859	203	R>C		No	ClinGen gnomAD
CA2387050 rs370984187	203	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA74181569 rs370984187	203	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA74181561 rs78420208	207	G>*		No	ClinGen Ensembl
TCGA novel	208	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1376218502 CA352999946	212	M>I		No	ClinGen gnomAD
rs756543786 CA2387048	212	M>K		No	ClinGen ExAC gnomAD
CA2387046 rs773371525	214	N>S		No	ClinGen ExAC TOPMed gnomAD
rs149225360 COSM308417 CA2387044	216	P>L	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA2387043 rs200561677	218	A>G		No	ClinGen ExAC TOPMed gnomAD
rs145418127 CA2387042	220	T>I		No	ClinGen ESP ExAC gnomAD
rs1373133879 CA352999886	222	V>L		No	ClinGen TOPMed
rs1410144174 CA352999874	224	T>A		No	ClinGen gnomAD
CA352999852 rs1477409426	227	G>D		No	ClinGen gnomAD
rs768200768 CA74181521	231	G>E		No	ClinGen Ensembl
rs1408830026 CA352999796	234	R>Q		No	ClinGen TOPMed
rs767517265 CA2387019	234	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1257624583 CA352999793	235	V>M		No	ClinGen gnomAD
rs759599282 CA2387018	239	R>K		No	ClinGen ExAC gnomAD
CA74175186 rs745366884	241	I>L		No	ClinGen TOPMed gnomAD
CA352999751 rs1253605778	241	I>T		No	ClinGen gnomAD
CA74175185 rs745366884	241	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	244	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA352999683 CA2387014 rs773425613	250	K>N		No	ClinGen ExAC TOPMed gnomAD
CA2387013 rs769911537	251	M>V		No	ClinGen ExAC gnomAD
rs761839330 CA2387012	254	S>L		No	ClinGen ExAC gnomAD
CA352999653 rs1575847192	255	F>I		No	ClinGen Ensembl
rs1300953461 CA352999626	258	S>C		No	ClinGen TOPMed gnomAD
rs1300953461 CA352999625	258	S>F		No	ClinGen TOPMed gnomAD
CA352999616 rs1229929940	260	P>S		No	ClinGen TOPMed gnomAD
rs747583679 CA2387009	263	K>R		No	ClinGen ExAC gnomAD
rs1575847125 CA352999579	266	E>A		No	ClinGen Ensembl
rs199701451 CA74174963	270	R>*	Variant assessed as Somatic; 4.627e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA gnomAD
CA74174965 rs199701451	270	R>G		No	ClinGen 1000Genomes gnomAD
COSM3427692 rs776689351 CA2386992	270	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA2386991 rs768783376	273	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1157459209 CA352999515	274	V>E		No	ClinGen gnomAD
CA74174928 rs1048816587	277	I>T		No	ClinGen Ensembl
rs1304727640 CA352999467	281	I>T		No	ClinGen gnomAD
CA2386989 rs775999526	281	I>V		No	ClinGen ExAC gnomAD
CA2386988 rs2230509	282	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1374377776 CA352999444	284	D>G		No	ClinGen TOPMed
rs1462169659 CA352999441	285	G>R		No	ClinGen TOPMed
rs541454235 CA2386987	287	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs779197243 CA2386986	287	R>H		No	ClinGen ExAC TOPMed gnomAD
CA352999425 rs779197243	287	R>L		No	ClinGen ExAC TOPMed gnomAD
CA74174899 rs777575285	288	I>V		No	ClinGen TOPMed gnomAD
rs1030263167 CA74174896	289	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1266447095 CA352999403	291	Q>*		No	ClinGen gnomAD
rs943125403 CA74168040	294	K>R		No	ClinGen TOPMed gnomAD
rs1327413424 CA352999363	295	A>P		No	ClinGen gnomAD
CA352999364 rs1327413424	295	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2386971 rs552838278	299	Y>H		No	ClinGen 1000Genomes ExAC
CA2386970 rs775458543	301	I>V		No	ClinGen ExAC gnomAD
rs1341468844 CA352999301	303	S>Y		No	ClinGen TOPMed
CA2386967 rs774770539	305	E>G		No	ClinGen ExAC gnomAD
rs368472573 CA74167949	305	E>K		No	ClinGen ESP TOPMed
CA74167948 rs368472573	305	E>Q		No	ClinGen ESP TOPMed
rs1575837050 CA352999284	306	V>G		No	ClinGen Ensembl
CA2386965 rs375396048	307	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA352999282 rs1468155106	307	S>R		No	ClinGen TOPMed
rs776351738 CA2386964	308	I>M		No	ClinGen ExAC gnomAD
rs768453904 CA2386963	310	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1244026936 CA352999253	311	R>K		No	ClinGen gnomAD
rs987168104 CA74167889	312	S>I		No	ClinGen Ensembl
CA2386962 rs202143115	313	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1575831649 CA352998757	314	T>P		No	ClinGen Ensembl
CA352998730 rs1249492445	316	S>P		No	ClinGen TOPMed gnomAD
CA2386947 rs773733467	317	N>H		No	ClinGen ExAC gnomAD
rs1437900183 CA352998713	317	N>S		No	ClinGen gnomAD
CA74164459 rs1036860610	318	K>T		No	ClinGen TOPMed gnomAD
rs768399019 CA2386946	320	G>A		No	ClinGen ExAC gnomAD
CA352998639 rs978918109	322	N>K		No	ClinGen Ensembl
rs7430328 CA74164432	324	E>K		No	ClinGen Ensembl
CA2386944 rs112025762 COSM1692762	326	E>K	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs771427219 CA2386943	327	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1343266127 CA352998579	328	A>P		No	ClinGen TOPMed
rs1343266127 CA352998578	328	A>S		No	ClinGen TOPMed
CA2386942 rs146193506	329	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2386941 rs778783320 COSM1263054	329	R>H	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs778783320 CA352998572	329	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1387006 CA352998559	331	H>L		No	ClinGen TOPMed gnomAD
rs1387006 CA74164363	331	H>P		No	ClinGen TOPMed gnomAD
CA352998558 rs1387006	331	H>R		No	ClinGen TOPMed gnomAD
rs1443111552 CA352998549	332	K>N		No	ClinGen gnomAD
rs544709818 CA2386940	333	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2386938 rs777586837	334	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA352998494 COSM3824089 rs1334259503	340	A>V	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA2386936 rs117433616	344	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs117433616 CA352998476	344	N>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200188798 CA2386935	344	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1234060932 CA352998464	345	K>N		No	ClinGen gnomAD
CA352998468 rs1470211366	345	K>Q		No	ClinGen TOPMed gnomAD
rs754942216 CA2386934	346	P>L		No	ClinGen ExAC gnomAD
rs754942216 CA352998458	346	P>R		No	ClinGen ExAC gnomAD
CA352998447 rs763603716	348	A>G		No	ClinGen ExAC TOPMed gnomAD
rs148604839 CA352998450	348	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA2386932 rs148604839	348	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs763603716 CA2386931	348	A>V		No	ClinGen ExAC TOPMed gnomAD
CA74164199 rs920918190	349	A>T		No	ClinGen TOPMed
CA352998437 rs1355333721	350	S>*		No	ClinGen TOPMed gnomAD
TCGA novel	353	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA352998421 rs1478995543	353	A>T		No	ClinGen Ensembl
CA352998412 rs1311610691	354	V>A		No	ClinGen TOPMed gnomAD
CA74164197 rs80024200	355	G>E		No	ClinGen gnomAD
rs762253998 CA352998397	356	D>E		No	ClinGen ExAC gnomAD
CA352998400 rs1375646539	356	D>G		No	ClinGen gnomAD
CA352998404 rs1402164503	356	D>N		No	ClinGen gnomAD
CA74164181 rs1015500058	358	K>Q		No	ClinGen TOPMed
rs1386130525 CA352998388	358	K>T		No	ClinGen gnomAD
CA2386909 rs762044416	363	D>N		No	ClinGen ExAC gnomAD
CA2386908 rs754252050	364	V>I		No	ClinGen ExAC gnomAD
CA352998316 rs1359639281	366	A>V		No	ClinGen gnomAD
CA352998306 rs1575830708	368	E>K		No	ClinGen Ensembl
CA2386905 rs375432861	373	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1173866135 CA352998267	374	C>F		No	ClinGen gnomAD
CA74163704 rs1007981501	375	M>T		No	ClinGen Ensembl
rs762460955 CA2386903	378	M>I		No	ClinGen ExAC gnomAD
CA352998235 rs1395103802	378	M>T		No	ClinGen gnomAD
rs1447244254 CA352998217	380	R>S		No	ClinGen gnomAD
rs1260569973 CA352998207	382	I>V		No	ClinGen gnomAD
rs772954329 CA2386902	384	H>Y		No	ClinGen ExAC gnomAD
CA2386901 rs769798310	385	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs747845378 CA2386900	390	V>M		No	ClinGen ExAC TOPMed gnomAD
CA2386897 rs747300998	392	M>I		No	ClinGen ExAC gnomAD
CA2386898 rs768966681	392	M>T		No	ClinGen ExAC TOPMed gnomAD
rs370946857 CA74163649	392	M>V		No	ClinGen ESP gnomAD
rs780266948 CA2386896	393	F>S		No	ClinGen ExAC gnomAD
rs148076464 CA2386895	394	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA352998119 rs1311011907	395	S>A		No	ClinGen gnomAD
rs377673441 CA352998112	396	S>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs377673441 CA2386894	396	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779242095 CA352998109	396	S>R		No	ClinGen ExAC gnomAD
rs754123758 CA2386891	397	V>A		No	ClinGen ExAC gnomAD
rs146859772 CA2386892	397	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1206703631 CA352998091	400	G>S		No	ClinGen TOPMed
rs754615800 CA2386889	401	N>S		No	ClinGen ExAC gnomAD
rs1013537238 CA74163590	402	L>R		No	ClinGen TOPMed gnomAD
rs374377380 CA2386887	403	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs762405819 CA352998065	404	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs762405819 CA2386886	404	Q>R		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with P13861

2 regional properties for P13861

Type	Name	Position	InterPro Accession
domain	SET domain	27 - 364	IPR001214
domain	SMYD5, SET domain	32 - 390	IPR044422

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cell membrane	Colocalizes with PJA2 in the cytoplasm and the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

12 GO annotations of cellular component

Name	Definition
cAMP-dependent protein kinase complex	An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
ciliary base	Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleotide-activated protein kinase complex	A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plasma membrane raft	A membrane raft that is part of the plasma membrane.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

6 GO annotations of molecular function

Name	Definition
cAMP binding	Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
cAMP-dependent protein kinase inhibitor activity	Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase.
cAMP-dependent protein kinase regulator activity	Modulation of the activity of the enzyme cAMP-dependent protein kinase.
protein domain specific binding	Binding to a specific domain of a protein.
protein kinase A catalytic subunit binding	Binding to one or both of the catalytic subunits of protein kinase A.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

2 GO annotations of biological process

Name	Definition
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of cAMP-dependent protein kinase activity	Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.

23 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P07278	BCY1	cAMP-dependent protein kinase regulatory subunit	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
P31322	PRKAR2B	cAMP-dependent protein kinase type II-beta regulatory subunit	Bos taurus (Bovine)	EV
P00514	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit	Bos taurus (Bovine)	EV
P00515	PRKAR2A	cAMP-dependent protein kinase type II-alpha regulatory subunit	Bos taurus (Bovine)	EV
Q5ZM91	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit	Gallus gallus (Chicken)	SS
P16905	Pka-R1	cAMP-dependent protein kinase type I regulatory subunit	Drosophila melanogaster (Fruit fly)	PR
P81900	Pka-R2	cAMP-dependent protein kinase type II regulatory subunit	Drosophila melanogaster (Fruit fly)	PR
Q96M20	CNBD2	Cyclic nucleotide-binding domain-containing protein 2	Homo sapiens (Human)	PR
P10644	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (Human)	EV
P31321	PRKAR1B	cAMP-dependent protein kinase type I-beta regulatory subunit	Homo sapiens (Human)	EV
P31323	PRKAR2B	cAMP-dependent protein kinase type II-beta regulatory subunit	Homo sapiens (Human)	PR
Q9D5U8	Cnbd2	Cyclic nucleotide-binding domain-containing protein 2	Mus musculus (Mouse)	PR
P12849	Prkar1b	cAMP-dependent protein kinase type I-beta regulatory subunit	Mus musculus (Mouse)	PR
P31324	Prkar2b	cAMP-dependent protein kinase type II-beta regulatory subunit	Mus musculus (Mouse)	PR
Q9DBC7	Prkar1a	cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]	Mus musculus (Mouse)	SS
P12367	Prkar2a	cAMP-dependent protein kinase type II-alpha regulatory subunit	Mus musculus (Mouse)	PR
P05207	PRKAR2A	cAMP-dependent protein kinase type II-alpha regulatory subunit	Sus scrofa (Pig)	SS
P07802	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit	Sus scrofa (Pig)	SS
P81377	Prkar1b	cAMP-dependent protein kinase type I-beta regulatory subunit	Rattus norvegicus (Rat)	PR
P09456	Prkar1a	cAMP-dependent protein kinase type I-alpha regulatory subunit	Rattus norvegicus (Rat)	SS
P12369	Prkar2b	cAMP-dependent protein kinase type II-beta regulatory subunit	Rattus norvegicus (Rat)	PR
P12368	Prkar2a	cAMP-dependent protein kinase type II-alpha regulatory subunit	Rattus norvegicus (Rat)	PR
P30625	kin-2	cAMP-dependent protein kinase regulatory subunit	Caenorhabditis elegans	SS

10	20	30	40	50	60
MSHIQIPPGL	TELLQGYTVE	VLRQQPPDLV	EFAVEYFTRL	REARAPASVL	PAATPRQSLG
70	80	90	100	110	120
HPPPEPGPDR	VADAKGDSES	EEDEDLEVPV	PSRFNRRVSV	CAETYNPDEE	EEDTDPRVIH
130	140	150	160	170	180
PKTDEQRCRL	QEACKDILLF	KNLDQEQLSQ	VLDAMFERIV	KADEHVIDQG	DDGDNFYVIE
190	200	210	220	230	240
RGTYDILVTK	DNQTRSVGQY	DNRGSFGELA	LMYNTPRAAT	IVATSEGSLW	GLDRVTFRRI
250	260	270	280	290	300
IVKNNAKKRK	MFESFIESVP	LLKSLEVSER	MKIVDVIGEK	IYKDGERIIT	QGEKADSFYI
310	320	330	340	350	360
IESGEVSILI	RSRTKSNKDG	GNQEVEIARC	HKGQYFGELA	LVTNKPRAAS	AYAVGDVKCL
370	380	390	400
VMDVQAFERL	LGPCMDIMKR	NISHYEEQLV	KMFGSSVDLG	NLGQ