P13599
Gene name |
Fcgrt (Fcrn) |
Protein name |
IgG receptor FcRn large subunit p51 |
Names |
N-CAM-1, NCAM-1, N-CAM-1, NCAM-1, N-CAM-1, NCAM-1, ICAM-1, MALA-2, MyD10, ICAM-2, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:29558 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P13599
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1FRT | X-ray | 450 A | A | 23-291 | PDB |
| 1I1A | X-ray | 280 A | A | 23-291 | PDB |
| 3FRU | X-ray | 220 A | A/C/E | 23-291 | PDB |
| AF-P13599-F1 | Predicted | AlphaFoldDB |
No variants for P13599
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P13599 | |||||
No associated diseases with P13599
4 regional properties for P13599
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Immunoglobulin/major histocompatibility complex, conserved site | 274 - 280 | IPR003006 |
| domain | Immunoglobulin C1-set | 215 - 286 | IPR003597 |
| domain | Immunoglobulin-like domain | 203 - 290 | IPR007110 |
| domain | MHC class I-like antigen recognition-like | 26 - 198 | IPR011161 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome membrane | The lipid bilayer surrounding an endosome. |
| external side of plasma membrane | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-2-microglobulin binding | Binding to beta-2-microglobulin. |
| IgG binding | Binding to an immunoglobulin of an IgG isotype. |
| IgG receptor activity | Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| humoral immune response | An immune response mediated through a body fluid. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P55899 | FCGRT | IgG receptor FcRn large subunit p51 | Homo sapiens (Human) | PR |
| Q61559 | Fcgrt | IgG receptor FcRn large subunit p51 | Mus musculus (Mouse) | PR |
| Q63493 | Cd1d | Antigen-presenting glycoprotein CD1d | Rattus norvegicus (Rat) | PR |
| O35799 | Hfe | Hereditary hemochromatosis protein homolog | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGMSQPGVLL | SLLLVLLPQT | WGAEPRLPLM | YHLAAVSDLS | TGLPSFWATG | WLGAQQYLTY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NNLRQEADPC | GAWIWENQVS | WYWEKETTDL | KSKEQLFLEA | IRTLENQING | TFTLQGLLGC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELAPDNSSLP | TAVFALNGEE | FMRFNPRTGN | WSGEWPETDI | VGNLWMKQPE | AARKESEFLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TSCPERLLGH | LERGRQNLEW | KEPPSMRLKA | RPGNSGSSVL | TCAAFSFYPP | ELKFRFLRNG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LASGSGNCST | GPNGDGSFHA | WSLLEVKRGD | EHHYQCQVEH | EGLAQPLTVD | LDSPARSSVP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VVGIILGLLL | VVVAIAGGVL | LWNRMRSGLP | APWLSLSGDD | SGDLLPGGNL | PPEAEPQGVN |
| AFPATS |