P12849
PR
Gene name |
Prkar1b |
Protein name |
cAMP-dependent protein kinase type I-beta regulatory subunit |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:19085 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P12849
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P12849-F1 | Predicted | AlphaFoldDB |
16 variants for P12849
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3396252708 | 37 | H>* | No | EVA | |
| rs3388796610 | 84 | P>S | No | EVA | |
| rs3388797846 | 86 | P>H | No | EVA | |
| rs3388804456 | 115 | R>T | No | EVA | |
| rs3388774210 | 147 | S>I | No | EVA | |
| rs3388805874 | 153 | M>L | No | EVA | |
| rs3388803192 | 164 | V>I | No | EVA | |
| rs3388803126 | 177 | I>S | No | EVA | |
| rs3388792216 | 185 | Y>* | No | EVA | |
| rs3388788374 | 189 | E>G | No | EVA | |
| rs3388785773 | 241 | R>M | No | EVA | |
| rs3388804146 | 253 | V>L | No | EVA | |
| rs3388805365 | 258 | S>T | No | EVA | |
| rs3388774254 | 284 | V>S | No | EVA | |
| rs3388804082 | 295 | I>F | No | EVA | |
| rs3396251216 | 337 | A>T | No | EVA |
No associated diseases with P12849
8 regional properties for P12849
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 137 - 253 | IPR000595-1 |
| domain | Cyclic nucleotide-binding domain | 255 - 376 | IPR000595-2 |
| domain | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | 25 - 62 | IPR003117 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 164 - 180 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 200 - 217 | IPR018488-2 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 282 - 298 | IPR018488-3 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 324 - 341 | IPR018488-4 |
| domain | RIbeta, dimerization/docking domain | 10 - 64 | IPR042818 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cAMP-dependent protein kinase complex | An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| hippocampal mossy fiber to CA3 synapse | One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. |
| multivesicular body | A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| Schaffer collateral - CA1 synapse | A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| cAMP-dependent protein kinase inhibitor activity | Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase. |
| cAMP-dependent protein kinase regulator activity | Modulation of the activity of the enzyme cAMP-dependent protein kinase. |
| protein kinase A catalytic subunit binding | Binding to one or both of the catalytic subunits of protein kinase A. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| animal organ morphogenesis | Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. |
| learning or memory | The acquisition and processing of information and/or the storage and retrieval of this information over time. |
| modulation of chemical synaptic transmission | Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. |
| negative regulation of cAMP-dependent protein kinase activity | Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity. |
| positive regulation of excitatory postsynaptic potential | Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| positive regulation of fear response | Any process that activates or increases the frequency, rate or extent of fear response. |
| positive regulation of long-term synaptic potentiation | Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. |
| positive regulation of sensory perception of pain | Any process that activates or increases the frequency, rate or extent of sensory perception of pain. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of protein kinase activity | Any process that modulates the frequency, rate or extent of protein kinase activity. |
| regulation of synaptic vesicle cycle | Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle. |
22 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P31322 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | Bos taurus (Bovine) | EV |
| P00514 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Bos taurus (Bovine) | EV |
| P00515 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Bos taurus (Bovine) | EV |
| Q5ZM91 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Gallus gallus (Chicken) | SS |
| P81900 | Pka-R2 | cAMP-dependent protein kinase type II regulatory subunit | Drosophila melanogaster (Fruit fly) | PR |
| P16905 | Pka-R1 | cAMP-dependent protein kinase type I regulatory subunit | Drosophila melanogaster (Fruit fly) | PR |
| Q96M20 | CNBD2 | Cyclic nucleotide-binding domain-containing protein 2 | Homo sapiens (Human) | PR |
| P10644 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Homo sapiens (Human) | EV |
| P13861 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Homo sapiens (Human) | PR |
| P31323 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | Homo sapiens (Human) | PR |
| P31321 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | Homo sapiens (Human) | EV |
| P12367 | Prkar2a | cAMP-dependent protein kinase type II-alpha regulatory subunit | Mus musculus (Mouse) | PR |
| Q9D5U8 | Cnbd2 | Cyclic nucleotide-binding domain-containing protein 2 | Mus musculus (Mouse) | PR |
| P31324 | Prkar2b | cAMP-dependent protein kinase type II-beta regulatory subunit | Mus musculus (Mouse) | PR |
| Q9DBC7 | Prkar1a | cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed] | Mus musculus (Mouse) | SS |
| P05207 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Sus scrofa (Pig) | SS |
| P07802 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Sus scrofa (Pig) | SS |
| P09456 | Prkar1a | cAMP-dependent protein kinase type I-alpha regulatory subunit | Rattus norvegicus (Rat) | SS |
| P12368 | Prkar2a | cAMP-dependent protein kinase type II-alpha regulatory subunit | Rattus norvegicus (Rat) | PR |
| P12369 | Prkar2b | cAMP-dependent protein kinase type II-beta regulatory subunit | Rattus norvegicus (Rat) | PR |
| P81377 | Prkar1b | cAMP-dependent protein kinase type I-beta regulatory subunit | Rattus norvegicus (Rat) | PR |
| P30625 | kin-2 | cAMP-dependent protein kinase regulatory subunit | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASPSCFHSE | DEDSLKGCEM | YVQKHGIQQV | LKECIVHLCV | AKPDRPLRFL | REHFEKLEKE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ENRQILARQK | SNSQCDSHDE | EISPTPPNPV | VKARRRRGGV | SAEVYTEEDA | VSYVRKVIPK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DYKTMTALAK | AISKNVLFSH | LDDNERSDIF | DAMFPVTHIG | GETVIQQGNE | GDNFYVIDQG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVDVYVNGEW | VTNISEGGSF | GELALIYGTP | RAATVKAKTD | LKLWGIDRDS | YRRILMGSTL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RKRKMYEEFL | SKVSILESLE | KWERLTVADA | LEPVQFEDGE | KIVVQGEPGD | DFYIITEGTA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SVLQRRSPNE | EYVEVGRLGP | SDYFGEIALL | LNRPRAATVV | ARGPLKCVKL | DRPRFERVLG |
| 370 | 380 | ||||
| PCSEILKRNI | QRYNSFISLT | V |