P11801

SS
Gene name
PSKH1
Protein name
Serine/threonine-protein kinase H1
Names
EC 2.7.11.1 , Protein serine kinase H1 , PSK-H1
Species
Homo sapiens (Human)
KEGG Pathway
hsa:5681
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

Serine/threonine-protein kinase H1 (PSKH1) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of PSKH1.

Autoinhibitory domains (AIDs)

Accessory elements

238-262 (Activation loop from InterPro)

Target domain

98-355 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P11801

Entry ID Method Resolution Chain Position Source
AF-P11801-F1 Predicted AlphaFoldDB

382 variants for P11801

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1269561499 2 G>D No gnomAD
rs764221259 5 T>I No ExAC
TOPMed
gnomAD
rs764221259 5 T>K No ExAC
TOPMed
gnomAD
rs763298582 5 T>P No ExAC
rs774585594 6 S>N No ExAC
gnomAD
rs1250866121 7 K>N No TOPMed
gnomAD
rs2058163591 8 V>A No Ensembl
rs889100595 8 V>I No TOPMed
gnomAD
rs760619786 9 L>I No ExAC
TOPMed
gnomAD
rs766401988 9 L>P No ExAC
gnomAD
rs764767985 11 E>K No ExAC
TOPMed
gnomAD
rs2058163686 12 P>L No gnomAD
rs758072788 12 P>S No ExAC
TOPMed
gnomAD
rs1273419897 13 P>S No TOPMed
gnomAD
rs777211025 14 K>R No ExAC
TOPMed
gnomAD
rs976552733 15 D>G No TOPMed
rs1598189210 15 D>N No TOPMed
rs138557834 16 V>I No ESP
ExAC
TOPMed
gnomAD
rs533725307 19 D>V No Ensembl
rs1174221423 24 V>M No TOPMed
gnomAD
rs1223803260 26 P>L No gnomAD
rs2058163843 26 P>T No TOPMed
gnomAD
rs2058163876 28 S>I No Ensembl
rs781752881 29 G>D No ExAC
TOPMed
gnomAD
rs781752881 29 G>V No ExAC
TOPMed
gnomAD
rs770154201 30 T>I No ExAC
gnomAD
rs1567399158 30 T>P No Ensembl
rs1236774193 31 K>N No gnomAD
rs780302290 31 K>R No ExAC
TOPMed
gnomAD
rs1481013467 32 S>G No gnomAD
rs749464076 32 S>I No ExAC
gnomAD
TCGA novel 32 S>V Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs769003520 33 D>N No ExAC
gnomAD
rs762038809 34 V>M No ExAC
TOPMed
gnomAD
rs374100286 37 H>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No Ensembl
NCI-TCGA
rs1356246890 40 T>I No gnomAD
rs759426626 42 V>M No ExAC
TOPMed
gnomAD
rs2058164101 43 D>N No TOPMed
rs2058164130 44 S>I No TOPMed
rs576450048 45 V>F No 1000Genomes
ExAC
TOPMed
gnomAD
rs146186709 46 G>C No ESP
ExAC
TOPMed
gnomAD
rs146186709 46 G>R No ESP
ExAC
TOPMed
gnomAD
rs146186709 46 G>S No ESP
ExAC
TOPMed
gnomAD
rs763803391 47 P>S No ExAC
TOPMed
gnomAD
rs1283454159 50 A>V No gnomAD
rs201663239 51 G>R No 1000Genomes
ExAC
TOPMed
gnomAD
rs750891126 52 F>L No ExAC
TOPMed
gnomAD
rs979745952 52 F>S No Ensembl
rs1207190109 53 P>L No gnomAD
rs2058164341 53 P>S No Ensembl
rs780398848
COSM3888787
 54 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
gnomAD
rs1482769126 55 A>G No TOPMed
gnomAD
rs2058164407 57 Q>* No Ensembl
rs372174162 58 Y>C No ESP
ExAC
TOPMed
gnomAD
rs1598189309 60 H>P No Ensembl
rs1339969747 60 H>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
rs545099030 61 P>S No Ensembl
rs1313538872 63 P>S No TOPMed
rs1056019516 64 G>D No TOPMed
gnomAD
rs139742716 64 G>S No ESP
ExAC
TOPMed
gnomAD
rs1056019516 64 G>V No TOPMed
gnomAD
rs560568634 65 P>S No gnomAD
rs560568634 65 P>T No gnomAD
rs144509198 66 P>L No ESP
ExAC
TOPMed
gnomAD
rs781187782 67 T>P No ExAC
TOPMed
gnomAD
COSM3361855 69 G>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1417999141 70 H>Q No TOPMed
rs2058164706 70 H>R No TOPMed
rs1788857944 71 T>A No TOPMed
gnomAD
rs753168298 71 T>M No ExAC
TOPMed
gnomAD
rs1567399224 73 P>R No Ensembl
TCGA novel 74 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM435551 75 S>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs2058164824 76 E>G No TOPMed
rs1230609617 77 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1236245758 77 P>S No TOPMed
rs2058164859 78 P>L No TOPMed
gnomAD
rs751254936 79 R>C No ExAC
TOPMed
gnomAD
rs1341567923
COSM972614
 79 R>H Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
TOPMed
gnomAD
rs1341567923 79 R>L No TOPMed
gnomAD
rs1275498288 80 R>K No TOPMed
gnomAD
rs2058164967 81 A>V No Ensembl
rs1217090998 82 R>G No TOPMed
gnomAD
rs1317491228 84 A>T No TOPMed
rs761392649 85 K>N No ExAC
TOPMed
gnomAD
rs936187440 86 Y>C No TOPMed
rs113404164 89 K>E No Ensembl
rs756639302 89 K>R No ExAC
gnomAD
rs767047171 93 R>C No ExAC
TOPMed
gnomAD
rs754228505
COSM4062004
 93 R>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
TOPMed
gnomAD
rs2058165140 94 V>I No TOPMed
rs764660707 98 Y>* No ExAC
gnomAD
rs754273417 99 D>V No ExAC
gnomAD
rs748355795 100 I>S No ExAC
rs2058165258 101 K>* No TOPMed
gnomAD
rs1345573875 102 A>V No gnomAD
rs747128704 106 R>Q No ExAC
TOPMed
gnomAD
rs775455575 111 R>* No ExAC
gnomAD
rs775455575 111 R>G No ExAC
gnomAD
rs1332605943 111 R>Q No gnomAD
rs1598189418 112 V>G No Ensembl
rs1209473224 114 R>C No TOPMed
gnomAD
rs768402377 114 R>H No ExAC
gnomAD
rs1209473224 114 R>S No TOPMed
gnomAD
rs774143232 115 V>I No ExAC
gnomAD
rs1598189427 117 H>P No Ensembl
rs2058165528 118 R>Q No gnomAD
rs55913417 118 R>W No 1000Genomes
ExAC
TOPMed
gnomAD
rs1445820858 119 A>V No TOPMed
gnomAD
rs1598189440 120 T>P No Ensembl
rs760148388 121 R>Q No ExAC
TOPMed
gnomAD
rs772761696 121 R>W No ExAC
TOPMed
gnomAD
rs754355030
COSM1609537
 123 P>L liver [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs2151312349 123 P>T No Ensembl
rs1598189453 124 Y>D No Ensembl
rs1458455792 124 Y>F No TOPMed
gnomAD
rs151268578 126 I>M No ESP
TOPMed
gnomAD
rs1318348259 126 I>V No TOPMed
gnomAD
rs1453369763 127 K>Q No gnomAD
rs1201861827 128 M>I No gnomAD
rs1338789283 129 I>T No gnomAD
rs2058165786 131 T>I No TOPMed
rs540279720 133 Y>* No ExAC
gnomAD
rs530075963 133 Y>C No ExAC
gnomAD
rs777914939 134 R>G No ExAC
TOPMed
gnomAD
rs570571625 134 R>Q No 1000Genomes
ExAC
TOPMed
gnomAD
rs777914939 134 R>W No ExAC
TOPMed
gnomAD
rs563460830 136 G>W No ExAC
gnomAD
rs1462044574 137 R>G No TOPMed
gnomAD
rs1441582991 137 R>Q No gnomAD
COSM1222312
rs1462044574
 137 R>W large_intestine [Cosmic] No cosmic curated
TOPMed
gnomAD
rs1598189487 139 V>G No Ensembl
TCGA novel 141 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs369110023 144 L>M No ESP
TOPMed
gnomAD
rs749163092 145 R>C No ExAC
TOPMed
gnomAD
rs768583092 145 R>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs2058165997 146 V>L No TOPMed
rs531259214 148 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No 1000Genomes
ExAC
NCI-TCGA
gnomAD
rs771730022 148 R>H No ExAC
TOPMed
gnomAD
rs1306879769 149 R>L No TOPMed
gnomAD
rs1306879769 149 R>Q No TOPMed
gnomAD
rs373245459 149 R>W No ESP
ExAC
gnomAD
rs1598189515 150 V>G No Ensembl
rs1399930911
COSM4062006
 151 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
TOPMed
gnomAD
rs1019592266 151 R>H No TOPMed
gnomAD
rs2151312374 153 A>S No Ensembl
rs2058166140 154 N>S No Ensembl
rs765915108 156 I>V No ExAC
TOPMed
gnomAD
rs753096981 157 Q>H No ExAC
gnomAD
rs377334046 159 V>M No ESP
ExAC
TOPMed
gnomAD
rs1598189535 161 V>G No Ensembl
rs2058166240 163 E>K No gnomAD
rs751693739
COSM1709301
 165 Q>R skin [Cosmic] No cosmic curated
ExAC
gnomAD
rs1701677720 166 E>D No gnomAD
rs2058166269 166 E>G No gnomAD
rs781180501 167 R>Q No ExAC
gnomAD
rs757495547 167 R>W No ExAC
gnomAD
rs1598189547 168 V>G No Ensembl
rs1483711142 168 V>M No gnomAD
rs201098098 170 M>L No ExAC
TOPMed
gnomAD
rs201098098 170 M>V No ExAC
TOPMed
gnomAD
rs1598189553 171 V>G No Ensembl
rs1433588898 173 E>D No gnomAD
rs771721386 175 A>G No ExAC
gnomAD
rs747940857 175 A>T No ExAC
gnomAD
rs2058166390 177 G>D No gnomAD
TCGA novel 178 G>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs746605543 178 G>V No ExAC
gnomAD
rs535771946 179 E>A No 1000Genomes
ExAC
gnomAD
rs776280871 183 R>C No ExAC
gnomAD
rs141391249 183 R>H No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1598189570 186 A>T No Ensembl
COSM972615 187 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1388714909 188 G>S No gnomAD
rs376814861 192 E>G No ESP
ExAC
TOPMed
gnomAD
rs775902065 192 E>K No ExAC
TOPMed
gnomAD
rs1277318997 193 R>C No TOPMed
gnomAD
rs764318654 193 R>H No ExAC
TOPMed
gnomAD
TCGA novel 194 D>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs2058166508 195 A>T No Ensembl
rs1598189583 195 A>V No Ensembl
rs1273243169 196 T>M No gnomAD
rs767784614 197 R>Q No ExAC
gnomAD
rs147652625 197 R>W No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1432318624 198 V>L No gnomAD
rs1432318624 198 V>M No gnomAD
rs752525986 200 Q>R No ExAC
gnomAD
rs777367014 206 V>D No ExAC
gnomAD
rs777367014 206 V>G No ExAC
gnomAD
rs2058166645 206 V>L No TOPMed
rs770694440 207 R>Q No ExAC
gnomAD
rs746869313 207 R>W No ExAC
TOPMed
gnomAD
rs781041385 212 L>V No ExAC
TOPMed
gnomAD
rs745344209 217 R>* No ExAC
gnomAD
rs2058166754 217 R>P No gnomAD
COSM972616 217 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1055067510 218 D>N No TOPMed
gnomAD
rs1289006170 225 L>F No TOPMed
rs763313027 226 Y>H No ExAC
gnomAD
rs2058166839 227 Y>D No Ensembl
rs2151312443 228 H>Y No Ensembl
TCGA novel 229 P>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1463531263 229 P>L No TOPMed
gnomAD
rs2058166850 229 P>T No TOPMed
TCGA novel 230 G>A Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1446385916 231 T>A No gnomAD
rs1316650317 231 T>I No Ensembl
rs774682036 234 K>E No ExAC
gnomAD
rs762209921 235 I>V No ExAC
TOPMed
gnomAD
rs773383066 236 I>T No ExAC
gnomAD
rs767690823 236 I>V No ExAC
TOPMed
gnomAD
rs368564776 243 A>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs143148420 246 R>C No ESP
ExAC
TOPMed
gnomAD
rs751378850 246 R>H No ExAC
TOPMed
gnomAD
rs751378850 246 R>P No ExAC
TOPMed
gnomAD
rs757163361 247 K>E No ExAC
gnomAD
COSM4756863 247 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs931071569 247 K>R No TOPMed
gnomAD
rs2058167048 248 K>M No Ensembl
rs2058167036 248 K>Q No Ensembl
rs781168612 249 G>D No ExAC
TOPMed
gnomAD
rs148210457 249 G>S No ESP
rs781168612 249 G>V No ExAC
TOPMed
gnomAD
rs745472725 252 C>R No ExAC
gnomAD
rs1214996799 252 C>Y No gnomAD
rs1484294432 256 T>S No TOPMed
gnomAD
rs1598189668 257 T>P No Ensembl
rs2058167138 257 T>S No TOPMed
COSM4062008
rs1180232058
 260 T>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
TOPMed
gnomAD
rs1473074727 262 E>A No gnomAD
rs1348475152 263 Y>S No TOPMed
gnomAD
rs192629945 264 I>L No 1000Genomes
ExAC
TOPMed
gnomAD
rs192629945 264 I>V No 1000Genomes
ExAC
TOPMed
gnomAD
rs919782915 265 A>P No Ensembl
rs1008475522 268 V>I No TOPMed
rs774874464 270 V>A No ExAC
gnomAD
rs748685487 271 R>C No ExAC
TOPMed
gnomAD
rs772373019 271 R>H No ExAC
TOPMed
gnomAD
rs772373019 271 R>L No ExAC
TOPMed
gnomAD
rs1453355214 273 P>L No TOPMed
gnomAD
rs1410057570 273 P>T No gnomAD
rs760740011 276 N>S No ExAC
TOPMed
gnomAD
rs766692223 277 S>L No ExAC
gnomAD
rs751505949 280 M>I No ExAC
gnomAD
rs759710609 280 M>L No ExAC
rs759710609 280 M>V No ExAC
rs2058167393 281 W>* No Ensembl
rs2058167404 282 A>T No TOPMed
rs2058167411 282 A>V No Ensembl
COSM703811 283 L>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM4926272 284 G>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs201009210 285 V>I No ESP
ExAC
TOPMed
gnomAD
rs1483385552 287 A>V No gnomAD
rs1017219009 292 S>C No TOPMed
gnomAD
rs1017219009 292 S>G No TOPMed
gnomAD
rs778417363 294 T>S No ExAC
gnomAD
rs1374332593 295 M>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
rs1429770607 296 P>L No gnomAD
VAR_040614
COSM3818304
rs35552721
 301 N>S breast [Cosmic] No cosmic curated
UniProt
ExAC
TOPMed
dbSNP
gnomAD
rs1275281711 302 R>C No TOPMed
gnomAD
COSM1222313
rs747466620
 302 R>H Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
gnomAD
rs1275281711 302 R>S No TOPMed
gnomAD
rs368590968 303 T>I No Ensembl
rs1279451077 304 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1217412354 304 R>W No gnomAD
rs776952921 307 R>L No ExAC
TOPMed
gnomAD
rs776952921 307 R>Q No ExAC
TOPMed
gnomAD
rs771036863 307 R>W No ExAC
TOPMed
gnomAD
rs1387936268 308 Q>H No TOPMed
gnomAD
rs1598189745 309 I>V No Ensembl
rs1022063287 310 L>I No TOPMed
gnomAD
rs769949236 311 R>G No ExAC
TOPMed
gnomAD
rs2058167746 313 K>N No TOPMed
rs2058167740 313 K>R No TOPMed
gnomAD
rs775728687 314 Y>D No ExAC
TOPMed
gnomAD
rs775728687 314 Y>H No ExAC
TOPMed
gnomAD
rs767617738 315 S>G No ExAC
TOPMed
gnomAD
rs750159369 315 S>N No ExAC
gnomAD
rs750159369 315 S>T No ExAC
gnomAD
rs1598189768 317 S>C No Ensembl
rs760554211 318 G>R No ExAC
gnomAD
rs760554211 318 G>W No ExAC
gnomAD
TCGA novel 319 E>S Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1252053815 323 S>G No TOPMed
gnomAD
rs749548353 330 D>N No ExAC
gnomAD
rs2058220147 332 I>N No TOPMed
rs183508494 334 R>C No 1000Genomes
ExAC
TOPMed
gnomAD
rs377532074 334 R>H No ESP
ExAC
TOPMed
gnomAD
rs2058220255 338 V>M No Ensembl
rs2058220265 342 A>V No Ensembl
rs770838620 343 R>C No ExAC
TOPMed
gnomAD
rs770838620 343 R>G No ExAC
TOPMed
gnomAD
rs1308905185 343 R>H No gnomAD
rs1308905185 343 R>L No gnomAD
COSM4062009 343 R>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1214099248 345 T>S No TOPMed
gnomAD
COSM972617 346 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs774453539 347 L>P No Ensembl
rs1598195256 352 H>P No Ensembl
rs1352594835 353 P>L No TOPMed
gnomAD
rs202036975 354 W>* No 1000Genomes
rs1598195270 355 V>G No Ensembl
rs1306749423 355 V>M No gnomAD
rs761912701 356 V>L No Ensembl
rs1232398074 357 S>R No TOPMed
gnomAD
rs1236153522 358 M>L No TOPMed
gnomAD
rs1567402817 358 M>R No Ensembl
rs1567402817 358 M>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No Ensembl
NCI-TCGA
rs1598195282 359 A>P No Ensembl
rs1273563995 360 A>D No TOPMed
gnomAD
rs1273563995 360 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
COSM972618 361 S>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs2058220460 363 S>F No gnomAD
rs764840386 364 M>V No ExAC
gnomAD
TCGA novel 367 L>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM4062010
rs199995143
 369 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
TOPMed
gnomAD
rs199995143 369 R>G No ExAC
TOPMed
gnomAD
COSM972619
rs763604843
 369 R>H large_intestine endometrium [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs199995143 369 R>S No ExAC
TOPMed
gnomAD
rs1296576921 370 S>F No TOPMed
rs1249639695 371 I>V No TOPMed
gnomAD
rs1567402832 373 Q>L No Ensembl
rs141214862 375 L>F No ESP
ExAC
TOPMed
gnomAD
rs145190865 378 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs202152584 378 R>H No 1000Genomes
ExAC
TOPMed
gnomAD
TCGA novel 379 A>G Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 379 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs756503993 380 S>P No ExAC
TOPMed
gnomAD
rs137887537 381 S>L No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs201909376 382 R>C No ExAC
TOPMed
gnomAD
rs575605513 382 R>H No 1000Genomes
ExAC
TOPMed
gnomAD
rs1008919267 383 C>Y No TOPMed
rs2058220681 386 T>A No Ensembl
rs1324257769 389 A>T No gnomAD
rs770877782 389 A>V No ExAC
rs766265181 390 Q>H No TOPMed
gnomAD
rs745836876 392 T>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs561480493 393 R>C No 1000Genomes
TOPMed
gnomAD
rs201432888
COSM972620
 393 R>H Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
1000Genomes
ExAC
NCI-TCGA
TOPMed
gnomAD
rs775281500 394 S>P No ExAC
gnomAD
rs1721410480 395 S>G No gnomAD
rs867603325 395 S>I No TOPMed
gnomAD
rs755016530 396 R>C No ExAC
TOPMed
gnomAD
rs778967004 396 R>H No ExAC
TOPMed
gnomAD
rs778967004 396 R>L No ExAC
TOPMed
gnomAD
rs773901928 398 T>I No ExAC
gnomAD
rs1467986549 398 T>S No gnomAD
COSM972621
rs1000942376
 399 R>C Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
TOPMed
gnomAD
rs968616577 399 R>H No TOPMed
gnomAD
rs2058220936 401 N>D No TOPMed
rs376293494 401 N>I No ESP
ExAC
TOPMed
gnomAD
rs376293494 401 N>S No ESP
ExAC
TOPMed
gnomAD
rs1333866869 402 K>R No TOPMed
gnomAD
rs2058220992 403 S>P No Ensembl
rs756698298 404 R>C No ExAC
gnomAD
rs766782692 404 R>H No ExAC
TOPMed
gnomAD
rs754320519 405 R>C No ExAC
TOPMed
gnomAD
rs755212982 405 R>H No ExAC
TOPMed
gnomAD
rs2058221074 406 V>A No Ensembl
rs779051799 406 V>L No ExAC
TOPMed
gnomAD
rs752646115 407 R>Q No TOPMed
gnomAD
COSM3691113
rs748229359
 407 R>W large_intestine [Cosmic] No cosmic curated
ExAC
gnomAD
rs1294185088 408 E>K No gnomAD
rs1234681997 409 R>Q No TOPMed
gnomAD
rs146152043 409 R>W No ESP
ExAC
TOPMed
gnomAD
rs1567402915 410 E>K No TOPMed
rs1567402915 410 E>Q No TOPMed
rs745748731 412 R>Q No ExAC
gnomAD
rs777852511 412 R>W No ExAC
TOPMed
gnomAD
rs1186493255 413 E>* No gnomAD
rs1186493255 413 E>K No gnomAD
rs1209336836 414 L>F No gnomAD
rs2058221259 415 N>H No TOPMed
rs1484831785 415 N>S No gnomAD
rs1186030654 417 R>C No TOPMed
gnomAD
rs1256886493 417 R>H No TOPMed
gnomAD
rs1425788462 419 Q>R No gnomAD
rs199646456 421 Q>* No 1000Genomes
ExAC
TOPMed
gnomAD
rs986396947 422 Y>* No TOPMed
gnomAD
rs915631938 423 N>H No Ensembl
rs1381152492 423 N>S No gnomAD
rs1343980301 424 G>S No gnomAD

No associated diseases with P11801

3 regional properties for P11801

Type Name Position InterPro Accession
domain Protein kinase domain 98 - 355 IPR000719
active_site Serine/threonine-protein kinase, active site 214 - 226 IPR008271
binding_site Protein kinase, ATP binding site 104 - 127 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Golgi apparatus
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Nucleus speckle
  • Endoplasmic reticulum membrane; Lipid-anchor
  • Cell membrane; Lipid-anchor
  • Cytoplasm
  • Localized in the brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm
  • Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells
  • The acylation-negative form may be only cytoplasmic and nuclear
  • Acylation seems to allow the sequestering to the intracellular membranes
  • Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes
  • Dual acylation is required to stabilize the interaction with Golgi membranes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions

3 GO annotations of biological process

Name Definition
determination of left/right symmetry The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

106 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A4IFM7 MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle Bos taurus (Bovine) SS
Q0VD22 STK33 Serine/threonine-protein kinase 33 Bos taurus (Bovine) PR
Q0V7M1 PSKH1 Serine/threonine-protein kinase H1 Bos taurus (Bovine) SS
O15075 DCLK1 Serine/threonine-protein kinase DCLK1 Homo sapiens (Human) EV
Q9UIK4 DAPK2 Death-associated protein kinase 2 Homo sapiens (Human) EV
O94768 STK17B Serine/threonine-protein kinase 17B Homo sapiens (Human) PR
Q16566 CAMK4 Calcium/calmodulin-dependent protein kinase type IV Homo sapiens (Human) SS
Q8N568 DCLK2 Serine/threonine-protein kinase DCLK2 Homo sapiens (Human) PR
Q9UEE5 STK17A Serine/threonine-protein kinase 17A Homo sapiens (Human) SS
O75962 TRIO Triple functional domain protein Homo sapiens (Human) EV
Q8WWF8 CAPSL Calcyphosin-like protein Homo sapiens (Human) PR
P53355 DAPK1 Death-associated protein kinase 1 Homo sapiens (Human) EV
Q9BYT3 STK33 Serine/threonine-protein kinase 33 Homo sapiens (Human) PR
O43293 DAPK3 Death-associated protein kinase 3 Homo sapiens (Human) PR
Q14012 CAMK1 Calcium/calmodulin-dependent protein kinase type 1 Homo sapiens (Human) EV
Q9H1R3 MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle Homo sapiens (Human) EV
Q16816 PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Homo sapiens (Human) PR
P15735 PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Homo sapiens (Human) PR
Q13554 CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta Homo sapiens (Human) EV
Q9UQM7 CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens (Human) EV
Q13555 CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma Homo sapiens (Human) EV
Q13557 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta Homo sapiens (Human) EV
Q32MK0 MYLK3 Myosin light chain kinase 3 Homo sapiens (Human) SS
Q86YV6 MYLK4 Myosin light chain kinase family member 4 Homo sapiens (Human) SS
Q6P2M8 PNCK Calcium/calmodulin-dependent protein kinase type 1B Homo sapiens (Human) SS
Q96NX5 CAMK1G Calcium/calmodulin-dependent protein kinase type 1G Homo sapiens (Human) SS
Q8IU85 CAMK1D Calcium/calmodulin-dependent protein kinase type 1D Homo sapiens (Human) SS
Q8NCB2 CAMKV CaM kinase-like vesicle-associated protein Homo sapiens (Human) SS
Q9QYK9 Pnck Calcium/calmodulin-dependent protein kinase type 1B Mus musculus (Mouse) PR
Q91VB2 Camk1g Calcium/calmodulin-dependent protein kinase type 1G Mus musculus (Mouse) SS
Q8BG48 Stk17b Serine/threonine-protein kinase 17B Mus musculus (Mouse) PR
Q8VCR8 Mylk2 Myosin light chain kinase 2, skeletal/cardiac muscle Mus musculus (Mouse) SS
Q6PGN3 Dclk2 Serine/threonine-protein kinase DCLK2 Mus musculus (Mouse) PR
Q91YS8 Camk1 Calcium/calmodulin-dependent protein kinase type 1 Mus musculus (Mouse) SS
Q3UIZ8 Mylk3 Myosin light chain kinase 3 Mus musculus (Mouse) SS
Q8VDF3 Dapk2 Death-associated protein kinase 2 Mus musculus (Mouse) EV
Q6P8Y1 Capsl Calcyphosin-like protein Mus musculus (Mouse) PR
Q8BW96 Camk1d Calcium/calmodulin-dependent protein kinase type 1D Mus musculus (Mouse) SS
Q3UHL1 Camkv CaM kinase-like vesicle-associated protein Mus musculus (Mouse) SS
P08414 Camk4 Calcium/calmodulin-dependent protein kinase type IV Mus musculus (Mouse) SS
Q9JLM8 Dclk1 Serine/threonine-protein kinase DCLK1 Mus musculus (Mouse) SS
Q80YE7 Dapk1 Death-associated protein kinase 1 Mus musculus (Mouse) SS
Q62407 Speg Striated muscle-specific serine/threonine-protein kinase Mus musculus (Mouse) SS
Q0KL02 Trio Triple functional domain protein Mus musculus (Mouse) SS
Q924X7 Stk33 Serine/threonine-protein kinase 33 Mus musculus (Mouse) PR
O54784 Dapk3 Death-associated protein kinase 3 Mus musculus (Mouse) PR
Q91YA2 Pskh1 Serine/threonine-protein kinase H1 Mus musculus (Mouse) SS
Q7TNJ7 Camk1g Calcium/calmodulin-dependent protein kinase type 1G Rattus norvegicus (Rat) SS
P20689 Mylk2 Myosin light chain kinase 2, skeletal/cardiac muscle Rattus norvegicus (Rat) SS
F1M0Z1 Trio Triple functional domain protein Rattus norvegicus (Rat) SS
Q91XS8 Stk17b Serine/threonine-protein kinase 17B Rattus norvegicus (Rat) PR
O08875 Dclk1 Serine/threonine-protein kinase DCLK1 Rattus norvegicus (Rat) PR
E9PT87 Mylk3 Myosin light chain kinase 3 Rattus norvegicus (Rat) SS
O70150 Pnck Calcium/calmodulin-dependent protein kinase type 1B Rattus norvegicus (Rat) PR
Q63092 Camkv CaM kinase-like vesicle-associated protein Rattus norvegicus (Rat) SS
Q63638 Speg Striated muscle-specific serine/threonine-protein kinase Rattus norvegicus (Rat) SS
O88764 Dapk3 Death-associated protein kinase 3 Rattus norvegicus (Rat) PR
P13234 Camk4 Calcium/calmodulin-dependent protein kinase type IV Rattus norvegicus (Rat) SS
Q63450 Camk1 Calcium/calmodulin-dependent protein kinase type 1 Rattus norvegicus (Rat) EV
P97924 Kalrn Kalirin Rattus norvegicus (Rat) SS
Q5MPA9 Dclk2 Serine/threonine-protein kinase DCLK2 Rattus norvegicus (Rat) PR
Q6AVM3 CCAMK Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase Oryza sativa subsp japonica (Rice) PR
P53682 CPK23 Calcium-dependent protein kinase 23 Oryza sativa subsp japonica (Rice) PR
P53684 CPK7 Calcium-dependent protein kinase 7 Oryza sativa subsp japonica (Rice) PR
Q5VQQ5 CPK2 Calcium-dependent protein kinase 2 Oryza sativa subsp. japonica (Rice) SS
Q6I5I8 CPK16 Calcium-dependent protein kinase 16 Oryza sativa subsp. japonica (Rice) SS
Q6K968 CPK6 Calcium-dependent protein kinase 6 Oryza sativa subsp. japonica (Rice) SS
Q75GE8 CPK8 Calcium-dependent protein kinase 8 Oryza sativa subsp. japonica (Rice) SS
Q84SL0 CPK20 Calcium-dependent protein kinase 20 Oryza sativa subsp. japonica (Rice) SS
Q8LPZ7 CPK3 Calcium-dependent protein kinase 3 Oryza sativa subsp. japonica (Rice) SS
Q9TXJ0 cmk-1 Calcium/calmodulin-dependent protein kinase type 1 Caenorhabditis elegans PR
O44997 dapk-1 Death-associated protein kinase dapk-1 Caenorhabditis elegans SS
Q95QC4 zyg-8 Serine/threonine-protein kinase zyg-8 Caenorhabditis elegans PR
P28583 Calcium-dependent protein kinase SK5 Glycine max (Soybean) (Glycine hispida) PR
Q9M9V8 CPK10 Calcium-dependent protein kinase 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FX86 CRK8 CDPK-related kinase 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SSF8 CPK30 Calcium-dependent protein kinase 30 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIQ7 CPK24 Calcium-dependent protein kinase 24 Arabidopsis thaliana (Mouse-ear cress) PR
P93759 GK-1 Calcium-dependent protein kinase 14 Arabidopsis thaliana (Mouse-ear cress) PR
Q8S8S2 LPEAT2 Lysophospholipid acyltransferase LPEAT2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LJL9 CRK2 CDPK-related kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SG12 CRK6 CDPK-related kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCS2 CRK5 CDPK-related kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W4I7 CPK13 Calcium-dependent protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NLQ6 CPK32 Calcium-dependent protein kinase 32 Arabidopsis thaliana (Mouse-ear cress) PR
Q38873 CPK7 Calcium-dependent protein kinase 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q42438 CPK8 Calcium-dependent protein kinase 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q06850 CPK1 Calcium-dependent protein kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q38869 CPK4 Calcium-dependent protein kinase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q38870 CPK2 Calcium-dependent protein kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q38872 CPK6 Calcium-dependent protein kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q39016 CPK11 Calcium-dependent protein kinase 11 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E9C0 CPK34 Calcium-dependent protein kinase 34 Arabidopsis thaliana (Mouse-ear cress) PR
Q42396 CPK12 Calcium-dependent protein kinase 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q42479 CPK3 Calcium-dependent protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q7XJR9 CPK16 Calcium-dependent protein kinase 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FMP5 CPK17 Calcium-dependent protein kinase 17 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SJ61 CPK25 Calcium-dependent protein kinase 25 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZSA4 CPK27 Calcium-dependent protein kinase 27 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZV15 CPK20 Calcium-dependent protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) PR
Q1PE17 CPK18 Calcium-dependent protein kinase 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FKW4 CPK28 Calcium-dependent protein kinase 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q38997 KIN10 SNF1-related protein kinase catalytic subunit alpha KIN10 Arabidopsis thaliana (Mouse-ear cress) SS
Q1LUA6 trio Triple functional domain protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
A8C984 mylk3 Myosin light chain kinase 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q7SY49 camkv CaM kinase-like vesicle-associated protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MGCGTSKVLP EPPKDVQLDL VKKVEPFSGT KSDVYKHFIT EVDSVGPVKA GFPAASQYAH
70 80 90 100 110 120
PCPGPPTAGH TEPPSEPPRR ARVAKYRAKF DPRVTAKYDI KALIGRGSFS RVVRVEHRAT
130 140 150 160 170 180
RQPYAIKMIE TKYREGREVC ESELRVLRRV RHANIIQLVE VFETQERVYM VMELATGGEL
190 200 210 220 230 240
FDRIIAKGSF TERDATRVLQ MVLDGVRYLH ALGITHRDLK PENLLYYHPG TDSKIIITDF
250 260 270 280 290 300
GLASARKKGD DCLMKTTCGT PEYIAPEVLV RKPYTNSVDM WALGVIAYIL LSGTMPFEDD
310 320 330 340 350 360
NRTRLYRQIL RGKYSYSGEP WPSVSNLAKD FIDRLLTVDP GARMTALQAL RHPWVVSMAA
370 380 390 400 410 420
SSSMKNLHRS ISQNLLKRAS SRCQSTKSAQ STRSSRSTRS NKSRRVRERE LRELNLRYQQ
QYNG