AiPD: Autoinhibited Protein Database

P11488

Gene name	GNAT1 (GNATR)
Protein name	Guanine nucleotide-binding protein G
Names	t subunit alpha-1 , Transducin alpha-1 chain
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2779
EC number
Protein Class

Descriptions

Gαi1 is a G-protein alpha subunit that plays a crucial role in signal transduction pathway initiated by G-protein-coupled receptor (GPCR) activation. G proteins function as transducers downstream of GPCRs in numerous signaling cascades. The alpha subunit contains the guanine nucleotide binding site and alternates between an active (GTP-bound state) and an inactive (GDP-bound state). Activated GPCR induces conformational change in Gαi1, which allows for GDP-to-GTP exchange by binding to the GPCR-binding site within a Ras-like domain, leading to dissociation of the Gαi1 subunit and initiation of downstream signaling.

Autoinhibitory domains (AIDs)

58-173 (α-H domain) SS

Target domain	180-344 (Ras-like domain)
Relief mechanism	Ligand binding, Partner binding
Assay

AID

58-173 (α-H domain)

Target domain

180-344 (Ras-like domain)

Relief mechanism

Ligand binding (GTP binding), Partner binding(Binding of activated GPCR)

Assay

Accessory elements

No accessory elements

References

Goricanec D et al. (2016) "Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding", Proceedings of the National Academy of Sciences of the United States of America, 113, E3629-38

Coleman DE et al. (1999) "Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex", The Journal of biological chemistry, 274, 16669-72

Lutz S et al. (2007) "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs", Science (New York, N.Y.), 318, 1923-7

Autoinhibited structure

Activated structure

2 structures for P11488

Entry ID	Method	Resolution	Chain	Position	Source
3RBQ	X-ray	200 A	G/H/I/J/K/L	2-11	PDB
AF-P11488-F1	Predicted				AlphaFoldDB

430 variants for P11488

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1575415957 RCV001003035	3	A>missing	Retinitis pigmentosa [ClinVar]	Yes	ClinVar dbSNP
RCV001412336 RCV000299430 CA2412421 rs201006405	13	R>K	Congenital stationary night blindness autosomal dominant 3 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000259457 CA2412433 rs149936603 RCV001437241	28	R>Q	Congenital stationary night blindness autosomal dominant 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001370367 rs772024349 RCV000787836	36	G>D	Retinitis pigmentosa Retinitis pigmentosa (rp) [ClinVar, Ensembl]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
RCV000017277 CA126053 VAR_009279 rs104893740	38	G>D	Congenital stationary night blindness autosomal dominant 3 CSNBAD3 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt ExAC dbSNP gnomAD
RCV002050635 rs765432703 RCV003355558	79	A>G	Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs201849628 RCV001498016 CA2412489 RCV000361876 RCV002520163	81	V>I	Inborn genetic diseases Congenital stationary night blindness autosomal dominant 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001197099 rs1699444080	87	L>F	Congenital stationary night blindness 1G [ClinVar]	Yes	ClinVar Ensembl dbSNP
RCV001388651 RCV002476734 rs143481438	91	Y>*	Congenital stationary night blindness autosomal dominant 3 [ClinVar]	Yes	ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001075209 rs778059585	95	A>missing	Retinal dystrophy [ClinVar]	Yes	ClinVar dbSNP
rs778497200 RCV001593238 RCV001060334	120	S>*	Congenital stationary night blindness autosomal dominant 3 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
RCV003166747 RCV001306731 rs199611280	125	R>Q	Inborn genetic diseases [ClinVar]	Yes	ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV002573468 RCV001971465 rs540227694	125	R>W	Inborn genetic diseases [ClinVar]	Yes	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV000171141 VAR_073798 rs786205854 CA250324	129	D>G	Congenital stationary night blindness 1G CSNB1G [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
rs771466852 RCV001347341 RCV002547075	148	A>S	Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
RCV001003036 rs1293620319	154	D>Y	Retinitis pigmentosa [ClinVar]	Yes	ClinVar TOPMed dbSNP gnomAD
rs1559746613 RCV000785165 RCV000785164	163	Y>S	Congenital stationary night blindness 1G Congenital stationary night blindness autosomal dominant 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
rs149647295 RCV001724867	170	V>L	Retinitis pigmentosa Retinitis pigmentosa (rp) [ClinVar, Ensembl]	Yes	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA199760 RCV000171140 rs786205853 VAR_073799	200	Q>E	Congenital stationary night blindness autosomal dominant 3 CSNBAD3 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
rs777846284 RCV003246877 RCV001321257	204	R>G	Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC dbSNP gnomAD
RCV001233414 rs769077570 RCV001150686	258	T>M	Congenital stationary night blindness autosomal dominant 3 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs751585772 RCV001351190 RCV002547518	270	F>L	Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs886058685 CA10616962 RCV000383999	277	A>V	Congenital stationary night blindness autosomal dominant 3 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
RCV000578484 RCV001237857 RCV001150687 CA2412765 rs374913800	302	Q>*	Congenital stationary night blindness 1G Congenital stationary night blindness autosomal dominant 3 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000382489 CA2412769 RCV001850834 rs367790137	309	R>P	Congenital stationary night blindness autosomal dominant 3 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs772111717 RCV001073737	316	Y>C	Retinal dystrophy [ClinVar]	Yes	ClinVar ExAC dbSNP gnomAD
rs1699480267 RCV001199362	339	I>V	Congenital stationary night blindness 1G [ClinVar]	Yes	ClinVar Ensembl dbSNP
RCV001348235 rs753375778	1	M>I		No	ClinVar dbSNP
RCV001968871 rs763736641	1	M>V		No	ClinVar dbSNP
rs1420138504	2	G>V		No	TOPMed gnomAD
rs1266812415 RCV002001578	3	A>T		No	ClinVar TOPMed dbSNP
rs1699413898 RCV001867666	4	G>R		No	ClinVar Ensembl dbSNP
rs1699413898	4	G>W		No	Ensembl
rs780667765 RCV001317593	6	S>G		No	ClinVar ExAC dbSNP gnomAD
rs1459356965	6	S>R		No	TOPMed gnomAD
rs1293986442 COSM1424120	7	A>V	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
TCGA novel	8	E>D	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1384503071	8	E>Q		No	gnomAD
rs1575415985	9	E>A		No	Ensembl
RCV000082616 rs398124522 CA224144	9	E>missing		No	ClinGen ClinVar dbSNP
COSM1424121	10	K>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1377171417	11	H>Y		No	gnomAD
rs748389570	14	E>D		No	ExAC TOPMed gnomAD
COSM5583542	14	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs770031393	16	E>G		No	ExAC gnomAD
rs1699414664	17	K>N		No	TOPMed
rs753761683 RCV001883391	18	K>missing		No	ClinVar dbSNP
rs1699414848	20	K>E		No	Ensembl
rs1177827474	23	A>D		No	gnomAD
rs1053549443	23	A>S		No	TOPMed gnomAD
rs1053549443	23	A>T		No	TOPMed gnomAD
rs1378270615	25	K>N		No	TOPMed gnomAD
rs1575416010	25	K>R		No	Ensembl
rs1425289444	26	D>E		No	gnomAD
rs1161256318	27	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1165407105	27	A>V		No	gnomAD
rs774214573 RCV000658963 COSM3595519	28	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ClinVar ExAC NCI-TCGA dbSNP gnomAD
rs149936603	28	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1400630067	29	T>A		No	gnomAD
rs145040990	30	V>L		No	ESP ExAC TOPMed gnomAD
rs145040990 RCV001878192	30	V>M		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs2109137515 RCV002025294	34	L>H		No	ClinVar Ensembl dbSNP
rs1487464362	36	G>S		No	TOPMed gnomAD
TCGA novel	38	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1347967126	38	G>S		No	gnomAD
rs34797487 RCV001307134	39	E>D		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1575416566	40	S>P		No	Ensembl
rs1699439597	41	G>A		No	Ensembl
rs768429545	41	G>W		No	ExAC
rs1699439647	42	K>E		No	TOPMed gnomAD
rs776367777	42	K>N		No	ExAC TOPMed gnomAD
rs1575416575	44	T>P		No	Ensembl
rs764910362 RCV002020824	46	V>I		No	ClinVar ExAC dbSNP gnomAD
COSM116906	47	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs749921670 RCV001910851	48	Q>E		No	ClinVar ExAC dbSNP gnomAD
rs1559746052	49	M>I		No	Ensembl
rs1466539542	49	M>V		No	TOPMed
rs2109138350 RCV001930469	50	K>missing		No	ClinVar dbSNP
rs1699441764	53	H>R		No	TOPMed
rs778486199	54	Q>*		No	Ensembl
rs776566245	55	D>E		No	ExAC TOPMed gnomAD
rs1041904269 RCV001305259	55	D>Y		No	ClinVar TOPMed dbSNP gnomAD
rs190126440	57	Y>*		No	1000Genomes TOPMed gnomAD
rs1242103172	60	E>K		No	TOPMed gnomAD
rs1242103172	60	E>Q		No	TOPMed gnomAD
rs1699442559	63	L>V		No	Ensembl
rs1352647422	65	F>L		No	gnomAD
rs762489106	70	Y>*		No	ExAC TOPMed gnomAD
rs767935708 RCV001373234	71	G>C		No	ClinVar ExAC dbSNP gnomAD
rs767935708	71	G>S		No	ExAC gnomAD
rs776116147	72	N>H		No	ExAC gnomAD
rs1236654107	73	T>K		No	TOPMed
rs1236654107 RCV001209348	73	T>M		No	ClinVar TOPMed dbSNP
rs1699443183	75	Q>*		No	Ensembl
COSM269252	75	Q>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
RCV001961109 rs764511104	77	I>F		No	ClinVar ExAC dbSNP gnomAD
RCV001314060 rs754189877	77	I>M		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs757483692	78	L>Q		No	ExAC gnomAD
rs765432703	79	A>D		No	ExAC TOPMed gnomAD
rs1699443540	80	I>M		No	TOPMed
rs1699443661	81	V>A		No	TOPMed gnomAD
rs201849628	81	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1406092062	82	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1699443746	82	R>H		No	TOPMed
rs1406092062	82	R>S		No	TOPMed gnomAD
RCV002040640 COSM145454 rs1325267297	83	A>T	Variant assessed as Somatic; MODERATE impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ClinVar NCI-TCGA TOPMed dbSNP gnomAD
rs1559746197	83	A>V		No	Ensembl
TCGA novel	84	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	85	T>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1575416692	85	T>P		No	Ensembl
rs2109138520 RCV001382720	86	T>missing		No	ClinVar dbSNP
rs1338199628	86	T>A		No	TOPMed gnomAD
rs2109138528	86	T>K		No	Ensembl
rs1338199628	86	T>P		No	TOPMed gnomAD
rs1338199628	86	T>S		No	TOPMed gnomAD
RCV002009853 rs767518257	88	N>S		No	ClinVar TOPMed dbSNP gnomAD
rs1375880116	89	I>L		No	gnomAD
rs1055779105	90	Q>*		No	Ensembl
COSM1424122	90	Q>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
RCV001244594 rs1403539761	91	Y>C		No	ClinVar Ensembl dbSNP
rs747889085	92	G>R		No	ExAC gnomAD
rs772876090 RCV001219562	93	D>G		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs2109138554 RCV001903560	93	D>I		No	ClinVar Ensembl dbSNP
rs769366813	93	D>N		No	ExAC TOPMed gnomAD
rs772876090	93	D>V		No	ExAC TOPMed gnomAD
COSM1046424	94	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1424123	96	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs748872282	96	R>H		No	ExAC TOPMed gnomAD
rs748872282	96	R>L		No	ExAC TOPMed gnomAD
rs1418453394	96	R>S		No	TOPMed gnomAD
rs1263559950	98	D>N		No	TOPMed gnomAD
rs1263559950	98	D>Y		No	TOPMed gnomAD
rs766450007	99	D>A		No	ExAC gnomAD
rs759644439	100	A>T		No	ExAC gnomAD
COSM1046426 rs767686983	101	R>Q	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1222830660	103	L>V		No	TOPMed gnomAD
rs1014696655	104	M>R		No	TOPMed
RCV001316043 rs1699447851	104	M>V		No	ClinVar Ensembl dbSNP
rs965873488	105	H>Y		No	TOPMed gnomAD
rs1699448058	106	M>I		No	gnomAD
rs752725817	106	M>L		No	ExAC gnomAD
rs918866339	106	M>T		No	Ensembl
rs752906907	107	A>V		No	TOPMed gnomAD
rs2109138728	109	T>S		No	Ensembl
RCV001226202 rs756003441	110	I>N		No	ClinVar ExAC dbSNP gnomAD
rs777683622	112	E>A		No	ExAC gnomAD
rs753519744	113	G>R		No	ExAC gnomAD
rs1279193204	114	T>M		No	TOPMed gnomAD
rs2109138755	119	M>I		No	Ensembl
rs778497200 COSM4118712	120	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC TOPMed gnomAD
rs778497200	120	S>W		No	ExAC TOPMed gnomAD
rs2109138765	121	D>H		No	1000Genomes
rs1453636003	122	I>S		No	gnomAD
rs771618545	122	I>V		No	ExAC gnomAD
rs200450293	123	I>L		No	1000Genomes ExAC TOPMed gnomAD
rs1699448634	123	I>N		No	TOPMed
rs200450293	123	I>V		No	1000Genomes ExAC TOPMed gnomAD
rs2109138776	124	Q>*		No	Ensembl
rs748754383	124	Q>R		No	ExAC gnomAD
TCGA novel	125	R>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs199611280	125	R>P		No	ESP ExAC TOPMed gnomAD
rs763156863 RCV001045234	126	L>Q		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs759804674	127	W>*		No	ExAC gnomAD
rs373544213	127	W>G		No	ESP ExAC TOPMed gnomAD
RCV001723414 rs373544213	127	W>R		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs928804929 RCV001948880	130	S>A		No	ClinVar Ensembl dbSNP
rs752708194	131	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
RCV001033959 rs141497735	132	I>S		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1240433262	133	Q>*		No	gnomAD
TCGA novel	133	Q>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1055894672	133	Q>P		No	Ensembl
RCV001301799 rs1699452379	134	A>G		No	ClinVar Ensembl dbSNP
rs1699452452	135	C>Y		No	TOPMed
rs753698158	136	F>S		No	ExAC TOPMed gnomAD
rs138533270	137	E>K		No	ESP ExAC
RCV001989206 rs1268403135	138	R>G		No	ClinVar TOPMed dbSNP gnomAD
rs2109138833	138	R>H		No	Ensembl
rs758039880	139	A>P		No	ExAC gnomAD
rs758039880	139	A>S		No	ExAC gnomAD
COSM2851060	139	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1440003996	140	S>*		No	TOPMed gnomAD
rs1361979499	141	E>*		No	TOPMed gnomAD
rs1453708491	141	E>G		No	gnomAD
rs1361979499	141	E>K		No	TOPMed gnomAD
TCGA novel	141	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs778098995	145	N>I		No	ExAC gnomAD
rs1699453394	146	D>E		No	TOPMed
rs1699453366	146	D>N		No	TOPMed
rs771466852	148	A>T		No	ExAC TOPMed gnomAD
TCGA novel	148	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs746153500	149	G>C		No	ExAC gnomAD
rs1306986926	149	G>D		No	TOPMed gnomAD
rs746153500	149	G>S		No	ExAC gnomAD
rs1306986926	149	G>V		No	TOPMed gnomAD
rs375063932	151	Y>*		No	ESP ExAC TOPMed gnomAD
rs752200483	151	Y>C		No	ExAC TOPMed gnomAD
rs1699457258	151	Y>N		No	TOPMed
rs1293620319	154	D>H		No	TOPMed gnomAD
rs1293620319 RCV001995962	154	D>N		No	ClinVar TOPMed dbSNP gnomAD
rs1279604764	155	L>P		No	gnomAD
rs1211321547	155	L>V		No	TOPMed gnomAD
rs779522093	157	R>C		No	ExAC gnomAD
rs779522093	157	R>G		No	ExAC gnomAD
rs1334509024	157	R>L		No	Ensembl
rs779522093	157	R>S		No	ExAC gnomAD
rs1242217198	159	V>I		No	TOPMed gnomAD
TCGA novel	160	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1474755659	160	T>N		No	TOPMed gnomAD
rs1474755659	160	T>S		No	TOPMed gnomAD
rs1399876988	161	P>A		No	TOPMed gnomAD
rs1699458313	161	P>L		No	TOPMed
rs1399876988 RCV002027438	161	P>T		No	ClinVar TOPMed dbSNP gnomAD
rs995607401	162	G>A		No	Ensembl
rs747259508	163	Y>*		No	ExAC gnomAD
rs1455904263	164	V>A		No	TOPMed gnomAD
rs1455904263	164	V>E		No	TOPMed gnomAD
rs1405575787	164	V>M		No	TOPMed gnomAD
rs781142235	165	P>R		No	ExAC gnomAD
rs768908387	165	P>S		No	ExAC gnomAD
rs1028826170	166	T>I		No	TOPMed gnomAD
rs1439988252	166	T>S		No	TOPMed
rs1028826170	166	T>S		No	TOPMed gnomAD
rs769750483 RCV001883932	167	E>*		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs749642690	167	E>D		No	TOPMed
rs769750483	167	E>K		No	ExAC TOPMed gnomAD
rs773081995	168	Q>R		No	ExAC gnomAD
rs1470513134	169	D>E		No	gnomAD
rs762850401	169	D>H		No	ExAC gnomAD
COSM1424125 rs149647295 RCV002049351	170	V>M	large_intestine Retinitis pigmentosa (rp) [Cosmic, Ensembl]	No	cosmic curated ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs2109139123 RCV001359694	171	L>Q		No	ClinVar Ensembl dbSNP
COSM1424126 rs1699459195	172	R>H	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs1699459195 RCV002276119	172	R>P		No	ClinVar TOPMed dbSNP
rs774185121	172	R>S		No	ExAC gnomAD
rs914564235	173	S>L		No	TOPMed
rs928754225	174	R>*		No	gnomAD
rs1699459406	174	R>L		No	TOPMed gnomAD
COSM4826728	174	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1699459521	175	V>A		No	TOPMed
rs760213416	175	V>I		No	ExAC TOPMed gnomAD
rs1314421649	177	T>I		No	Ensembl
rs1213030549	178	T>I		No	gnomAD
rs1243899846	178	T>S		No	TOPMed
rs1468622659	180	I>N		No	TOPMed gnomAD
RCV001314657 rs751005737	181	I>M		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs758939252	182	E>K		No	ExAC gnomAD
rs1452893155	183	T>A		No	TOPMed gnomAD
rs375795574 COSM3781656	183	T>M	Variant assessed as Somatic; MODERATE impact. pancreas [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
RCV001058966 rs1452893155	183	T>P		No	ClinVar TOPMed dbSNP gnomAD
rs1409342994	184	Q>*		No	gnomAD
rs1559746732	184	Q>H		No	Ensembl
rs751891744	184	Q>L		No	ExAC TOPMed gnomAD
rs1419856584	185	F>I		No	Ensembl
rs1699460164	186	S>Y		No	Ensembl
COSM731215	187	F>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	189	D>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1272845943	189	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
COSM1309296	190	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs372188249	191	N>K		No	1000Genomes TOPMed gnomAD
RCV002036932 rs1042087188	192	F>L		No	ClinVar TOPMed dbSNP gnomAD
rs755156826	193	R>P		No	ExAC TOPMed gnomAD
rs755156826	193	R>Q		No	ExAC TOPMed gnomAD
rs1699464808	194	M>I		No	Ensembl
rs928625009	194	M>L		No	TOPMed gnomAD
rs928625009	194	M>V		No	TOPMed gnomAD
rs960398499	195	F>V		No	TOPMed gnomAD
rs751898545	197	V>M		No	ExAC TOPMed gnomAD
rs755317184	199	G>R		No	ExAC gnomAD
rs755317184	199	G>W		No	ExAC gnomAD
rs1221785183	201	R>G		No	TOPMed
rs752987189	201	R>H		No	ExAC TOPMed gnomAD
rs752987189	201	R>P		No	ExAC TOPMed gnomAD
rs1699465186	202	S>L		No	TOPMed
rs571471319 RCV002000220	203	E>*		No	ClinVar 1000Genomes TOPMed dbSNP gnomAD
rs777846284	204	R>C		No	ExAC gnomAD
rs749325459	204	R>L		No	ExAC TOPMed gnomAD
rs749325459	204	R>P		No	ExAC TOPMed gnomAD
rs777846284	204	R>S		No	ExAC gnomAD
COSM1309297	205	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1699465451	206	K>E		No	Ensembl
rs2109139429	207	W>*		No	Ensembl
rs1559746925	207	W>C		No	Ensembl
TCGA novel	207	W>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1448085077	208	I>N		No	TOPMed gnomAD
rs1699465595	209	H>Y		No	Ensembl
rs2109139440	210	C>F		No	Ensembl
TCGA novel	211	F>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs745771623	212	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs745771623	212	E>Q		No	ExAC gnomAD
rs538795841	213	G>D		No	1000Genomes ExAC gnomAD
rs1327628053	213	G>S		No	gnomAD
RCV002003157 rs538795841	213	G>V		No	ClinVar 1000Genomes ExAC dbSNP gnomAD
rs1269159422	215	T>A		No	TOPMed gnomAD
rs746716339	215	T>I		No	ExAC gnomAD
rs1699465851	216	C>Y		No	TOPMed
COSM480246	217	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs768364063 RCV001364595	218	I>T		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs1486272162	219	F>L		No	gnomAD
rs1699466014	219	F>Y		No	TOPMed
rs1699466127	221	A>T		No	TOPMed
rs766815295	222	A>E		No	ExAC gnomAD
rs558297346	222	A>S		No	1000Genomes ExAC TOPMed gnomAD
rs1372709296 COSM3824210	225	A>T	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
RCV001359881 rs2109139492	225	A>V		No	ClinVar Ensembl dbSNP
rs534226069	226	Y>*		No	1000Genomes ExAC TOPMed gnomAD
rs1699466674	228	M>I		No	Ensembl
rs753005762	228	M>V		No	ExAC gnomAD
rs1382184490	231	V>A		No	TOPMed
rs764263965	231	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1317279783	232	E>A		No	gnomAD
rs1179340527	233	D>H		No	TOPMed gnomAD
rs1179340527	233	D>N		No	TOPMed gnomAD
rs1226709526	234	D>N		No	gnomAD
RCV001767606 rs1306113271	235	E>K		No	ClinVar TOPMed dbSNP gnomAD
rs1348995092	236	V>M		No	gnomAD
rs751418123	238	R>H		No	ExAC gnomAD
rs751418123	238	R>L		No	ExAC gnomAD
rs1348727426 RCV002003884	239	M>T		No	ClinVar TOPMed dbSNP gnomAD
rs373605188	240	H>Y		No	ESP ExAC TOPMed gnomAD
rs1699472592	241	E>D		No	TOPMed gnomAD
rs1699472630	242	S>R		No	TOPMed
rs780817002	243	L>M		No	ExAC gnomAD
rs940268662	244	H>P		No	TOPMed gnomAD
rs1699472741	245	L>P		No	TOPMed
COSM731214 rs1252882654	249	I>V	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs747897846	250	C>R		No	ExAC TOPMed gnomAD
rs200018227	251	N>K		No	1000Genomes ExAC TOPMed gnomAD
rs1476813148	252	H>R		No	TOPMed gnomAD
rs777343556	253	R>C		No	ExAC gnomAD
rs777343556	253	R>G		No	ExAC gnomAD
rs1475939846 RCV001983314	253	R>H		No	ClinVar dbSNP gnomAD
rs748761041	254	Y>H		No	ExAC TOPMed gnomAD
rs772592889	255	F>L		No	ExAC gnomAD
rs772592889	255	F>V		No	ExAC gnomAD
rs79816946	257	T>M		No	ExAC gnomAD
rs1405282226	257	T>P		No	gnomAD
rs2109139828	258	T>S		No	Ensembl
rs370211781	260	I>V		No	ESP
rs1416751412	261	V>A		No	TOPMed gnomAD
rs1416751412	261	V>E		No	TOPMed gnomAD
rs1416751412	261	V>G		No	TOPMed gnomAD
TCGA novel	261	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
RCV001315070 rs762106912	262	L>F		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs765309886	264	L>V		No	ExAC TOPMed gnomAD
rs763074721	268	D>A		No	ExAC gnomAD
rs766541249	269	V>F		No	ExAC
rs766541249	269	V>L		No	ExAC
rs754959065	271	F>L		No	ExAC TOPMed gnomAD
rs1699474190	272	E>G		No	TOPMed
RCV001864492 rs1276796249	273	K>missing		No	ClinVar dbSNP
rs1486599826	273	K>N		No	TOPMed gnomAD
rs947123026 RCV001903038	275	K>N		No	ClinVar TOPMed dbSNP gnomAD
rs752370885	275	K>R		No	ExAC TOPMed gnomAD
rs1481950985	276	K>E		No	TOPMed gnomAD
rs1187921368	276	K>M		No	gnomAD
rs886058685	277	A>G		No	TOPMed gnomAD
rs532366141	278	H>Y		No	1000Genomes ExAC gnomAD
rs187456952	279	L>F		No	1000Genomes ExAC TOPMed gnomAD
rs778392995	281	I>V		No	ExAC gnomAD
rs2109139906 RCV002015433	285	D>G		No	ClinVar Ensembl dbSNP
rs1699474879	287	D>N		No	Ensembl
rs773704753	289	P>S		No	ExAC TOPMed gnomAD
rs954449962	290	N>H		No	TOPMed gnomAD
rs749576739	290	N>K		No	ExAC gnomAD
rs771213734	292	Y>C		No	ExAC TOPMed gnomAD
rs759489972	293	E>*		No	ExAC TOPMed gnomAD
COSM281413	293	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs759489972	293	E>K		No	ExAC TOPMed gnomAD
rs759489972	293	E>Q		No	ExAC TOPMed gnomAD
rs1013548480	294	D>V		No	Ensembl
rs371673064	295	A>S		No	ESP ExAC gnomAD
rs371673064	295	A>T		No	ESP ExAC gnomAD
RCV001300189 rs1241953207	296	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinVar NCI-TCGA TOPMed dbSNP gnomAD
rs1219121764	297	N>D		No	TOPMed gnomAD
rs1699477139	297	N>K		No	TOPMed
rs763936466	297	N>S		No	ExAC gnomAD
rs753572984	298	Y>N		No	ExAC gnomAD
RCV001238593 rs772467993	299	I>missing		No	ClinVar dbSNP
rs756905728	300	K>E		No	ExAC TOPMed gnomAD
rs764827963	301	V>M		No	ExAC TOPMed gnomAD
rs757893975	302	Q>R		No	ExAC gnomAD
rs779581721	304	L>F		No	ExAC TOPMed gnomAD
rs1358427033	304	L>H		No	TOPMed
rs779581721	304	L>I		No	ExAC TOPMed gnomAD
rs1399146386	305	E>*		No	TOPMed
rs753206978	305	E>G		No	ExAC gnomAD
rs924423072	308	M>L		No	Ensembl
rs1699478168 RCV001302534	308	M>T		No	ClinVar Ensembl dbSNP
rs924423072	308	M>V		No	Ensembl
rs367790137	309	R>Q		No	ESP ExAC TOPMed gnomAD
rs778292500	310	R>C		No	ExAC gnomAD
rs1207261147	311	D>E		No	gnomAD
RCV001048725 rs999064639	311	D>N		No	ClinVar dbSNP gnomAD
rs999064639	311	D>Y		No	gnomAD
rs1233953441	312	V>L		No	TOPMed gnomAD
COSM77783 rs1416616268	314	E>D	ovary [Cosmic]	No	cosmic curated TOPMed
COSM3595520 rs779330892	314	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs746076205 RCV001242161	315	I>V		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs376830581	316	Y>*		No	ESP ExAC TOPMed gnomAD
rs776440552	319	M>I		No	ExAC gnomAD
rs752720192	319	M>V		No	ExAC TOPMed gnomAD
rs1369841395	320	T>K		No	TOPMed gnomAD
rs761545070	321	C>*		No	ExAC gnomAD
rs764994417	322	A>V		No	ExAC gnomAD
rs1699479544	323	T>A		No	TOPMed gnomAD
rs895692880	324	D>N		No	TOPMed gnomAD
rs750079496	325	T>M		No	ExAC gnomAD
rs750079496	325	T>R		No	ExAC gnomAD
rs765861017	326	Q>H		No	ExAC gnomAD
rs1440961711	326	Q>K		No	gnomAD
rs1699479769	326	Q>P		No	Ensembl
rs567554388	328	V>L		No	1000Genomes ExAC gnomAD
rs202170742	329	K>I		No	ExAC TOPMed gnomAD
RCV001063050 rs202170742	329	K>T		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs754379390	332	F>L		No	ExAC gnomAD
RCV001246958 rs1699480118	335	V>A		No	ClinVar TOPMed dbSNP
rs1699480118	335	V>D		No	TOPMed
rs140221218	335	V>I		No	ESP ExAC TOPMed gnomAD
rs140221218	335	V>L		No	ESP ExAC TOPMed gnomAD
rs1366927641	336	T>I		No	gnomAD
RCV001359238 rs2109140172	339	I>missing		No	ClinVar dbSNP
rs1168259545	340	I>S		No	gnomAD
rs1389264153	341	K>R		No	TOPMed gnomAD
TCGA novel rs1699480385	342	E>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
TCGA novel	342	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs780003957	342	E>K		No	ExAC gnomAD
rs747068938 RCV001887667	343	N>S		No	ClinVar ExAC dbSNP gnomAD
rs551001437	344	L>V		No	Ensembl
rs1375537782	346	D>G		No	gnomAD
rs1331868461	349	L>H		No	gnomAD
rs1445156543	351	F>L		No	TOPMed gnomAD

1 associated diseases with P11488

Without disease ID

5 regional properties for P11488

Type	Name	Position	InterPro Accession
domain	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	486 - 819	IPR002073
domain	GAF domain	75 - 234	IPR003018-1
domain	GAF domain	256 - 443	IPR003018-2
domain	HD/PDEase domain	559 - 746	IPR003607
conserved_site	3'5'-cyclic nucleotide phosphodiesterase, conserved site	602 - 613	IPR023174

Functions

		Description
EC Number
Subcellular Localization	Cell projection, cilium, photoreceptor outer segment Membrane ; Peripheral membrane protein Photoreceptor inner segment	Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

12 GO annotations of cellular component

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
heterotrimeric G-protein complex	Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
photoreceptor connecting cilium	The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.
photoreceptor disc membrane	Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
photoreceptor inner segment	The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
photoreceptor outer segment	The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
photoreceptor outer segment membrane	The membrane surrounding the outer segment of a vertebrate photoreceptor.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

8 GO annotations of molecular function

Name	Definition
acyl binding	Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.
G protein-coupled receptor binding	Binding to a G protein-coupled receptor.
G-protein beta/gamma-subunit complex binding	Binding to a complex of G-protein beta/gamma subunits.
GDP binding	Binding to GDP, guanosine 5'-diphosphate.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction
metal ion binding	Binding to a metal ion.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

21 GO annotations of biological process

Name	Definition
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
background adaptation	Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity.
cell population proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cellular response to electrical stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
detection of chemical stimulus involved in sensory perception of bitter taste	The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
detection of light stimulus involved in visual perception	The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
dopamine secretion	The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone.
eye photoreceptor cell development	Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.
negative regulation of cyclic-nucleotide phosphodiesterase activity	Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction
neural tissue regeneration	The regrowth of neural tissue following its loss or destruction.
phototransduction, visible light	The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
regulation of rhodopsin mediated signaling pathway	Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.
response to light stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
response to organic cyclic compound	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
retinal cone cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.
retinal rod cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell.
rhodopsin mediated signaling pathway	A G protein-coupled receptor signaling pathway initiated by the excitation of rhodopsin by a photon, and ending with the regulation of a downstream cellular process.
sensory perception of umami taste	The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
visual behavior	The behavior of an organism in response to a visual stimulus.
visual perception	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

61 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P63097	GNAI1	Guanine nucleotide-binding protein G	Bos taurus (Bovine)	SS
P0C7Q4	GNAT3	Guanine nucleotide-binding protein G	Bos taurus (Bovine)	SS
P04696	GNAT2	Guanine nucleotide-binding protein G	Bos taurus (Bovine)	SS
P08239	GNAO1	Guanine nucleotide-binding protein G	Bos taurus (Bovine)	SS
P04695	GNAT1	Guanine nucleotide-binding protein G	Bos taurus (Bovine)	SS
P50147	GNAI2	Guanine nucleotide-binding protein G	Gallus gallus (Chicken)	SS
P50146	GNAI1	Guanine nucleotide-binding protein G	Gallus gallus (Chicken)	SS
P20353	Galphai	G protein alpha i subunit	Drosophila melanogaster (Fruit fly)	SS
P16378	Galphao	G protein alpha o subunit	Drosophila melanogaster (Fruit fly)	SS
P25157	cta	Guanine nucleotide-binding protein subunit alpha homolog	Drosophila melanogaster (Fruit fly)	SS
A8MTJ3	GNAT3	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P08754	GNAI3	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P19086	GNAZ	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P19087	GNAT2	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P29992	GNA11	Guanine nucleotide-binding protein subunit alpha-11	Homo sapiens (Human)	SS
P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	Homo sapiens (Human)	SS
P50148	GNAQ	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
O95837	GNA14	Guanine nucleotide-binding protein subunit alpha-14	Homo sapiens (Human)	SS
Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	Homo sapiens (Human)	SS
Q03113	GNA12	Guanine nucleotide-binding protein subunit alpha-12	Homo sapiens (Human)	SS
P38405	GNAL	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P04899	GNAI2	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P63096	GNAI1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	EV
P09471	GNAO1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
Q9DC51	Gnai3	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P27600	Gna12	Guanine nucleotide-binding protein subunit alpha-12	Mus musculus (Mouse)	SS
P27601	Gna13	Guanine nucleotide-binding protein subunit alpha-13	Mus musculus (Mouse)	SS
Q3V3I2	Gnat3	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
O70443	Gnaz	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P50149	Gnat2	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P08752	Gnai2	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
B2RSH2	Gnai1	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P18872	Gnao1	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P20612	Gnat1	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P93564	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Solanum tuberosum (Potato)	SS
Q63210	Gna12	Guanine nucleotide-binding protein subunit alpha-12	Rattus norvegicus (Rat)	SS
P19627	Gnaz	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
P29348	Gnat3	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
P04897	Gnai2	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
P59215	Gnao1	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
P08753	Gnai3	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
Q6Q7Y5	Gna13	Guanine nucleotide-binding protein subunit alpha-13	Rattus norvegicus (Rat)	SS
Q0DJ33	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Oryza sativa subsp. japonica (Rice)	SS
P51875	goa-1	Guanine nucleotide-binding protein G	Caenorhabditis elegans	SS
Q18434	odr-3	Guanine nucleotide-binding protein alpha-17 subunit	Caenorhabditis elegans	SS
Q9BIG4	gpa-10	Guanine nucleotide-binding protein alpha-10 subunit	Caenorhabditis elegans	PR
P28052	gpa-3	Guanine nucleotide-binding protein alpha-3 subunit	Caenorhabditis elegans	SS
Q9XTB2	gpa-13	Guanine nucleotide-binding protein alpha-13 subunit	Caenorhabditis elegans	SS
Q9BIG5	gpa-4	Guanine nucleotide-binding protein alpha-4 subunit	Caenorhabditis elegans	SS
P28051	gpa-1	Guanine nucleotide-binding protein alpha-1 subunit	Caenorhabditis elegans	SS
Q9N2V6	gpa-16	Guanine nucleotide-binding protein alpha-16 subunit	Caenorhabditis elegans	SS
P91907	gpa-15	Guanine nucleotide-binding protein alpha-15 subunit	Caenorhabditis elegans	SS
Q20907	gpa-8	Guanine nucleotide-binding protein alpha-8 subunit	Caenorhabditis elegans	PR
Q21917	gpa-7	Guanine nucleotide-binding protein alpha-7 subunit	Caenorhabditis elegans	SS
Q93743	gpa-6	Guanine nucleotide-binding protein alpha-6 subunit	Caenorhabditis elegans	SS
O76584	gpa-11	Guanine nucleotide-binding protein alpha-11 subunit	Caenorhabditis elegans	SS
P49084	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Glycine max (Soybean) (Glycine hispida)	SS
P93163	GPA2	Guanine nucleotide-binding protein alpha-2 subunit	Glycine max (Soybean) (Glycine hispida)	SS
O80462	XLG1	Extra-large guanine nucleotide-binding protein 1	Arabidopsis thaliana (Mouse-ear cress)	PR
P18064	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Arabidopsis thaliana (Mouse-ear cress)	SS
P26981	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	SS

10	20	30	40	50	60
MGAGASAEEK	HSRELEKKLK	EDAEKDARTV	KLLLLGAGES	GKSTIVKQMK	IIHQDGYSLE
70	80	90	100	110	120
ECLEFIAIIY	GNTLQSILAI	VRAMTTLNIQ	YGDSARQDDA	RKLMHMADTI	EEGTMPKEMS
130	140	150	160	170	180
DIIQRLWKDS	GIQACFERAS	EYQLNDSAGY	YLSDLERLVT	PGYVPTEQDV	LRSRVKTTGI
190	200	210	220	230	240
IETQFSFKDL	NFRMFDVGGQ	RSERKKWIHC	FEGVTCIIFI	AALSAYDMVL	VEDDEVNRMH
250	260	270	280	290	300
ESLHLFNSIC	NHRYFATTSI	VLFLNKKDVF	FEKIKKAHLS	ICFPDYDGPN	TYEDAGNYIK
310	320	330	340
VQFLELNMRR	DVKEIYSHMT	CATDTQNVKF	VFDAVTDIII	KENLKDCGLF