Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P11403

Entry ID Method Resolution Chain Position Source
AF-P11403-F1 Predicted AlphaFoldDB

8 variants for P11403

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1134385044 3 K>N No EVA
rs1135369471 5 G>R No EVA
rs245226391 47 V>M No EVA
rs1132078627 80 R>Q No EVA
rs3388963830 116 P>R No EVA
rs3388953309 161 N>H No EVA
rs3388963608 166 E>K No EVA
rs3388960136 185 K>N No EVA

No associated diseases with P11403

3 regional properties for P11403

Type Name Position InterPro Accession
domain Protein kinase domain 33 - 289 IPR000719
active_site Serine/threonine-protein kinase, active site 148 - 160 IPR008271
binding_site Protein kinase, ATP binding site 39 - 62 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

2 GO annotations of molecular function

Name Definition
fibroblast growth factor receptor binding Binding to a fibroblast growth factor receptor (FGFR).
growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

29 GO annotations of biological process

Name Definition
animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
apoptotic process involved in morphogenesis Any apoptotic process that contributes to the shaping of an anatomical structure.
cartilage condensation The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cellular response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
chondroblast differentiation The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.
cranial suture morphogenesis The process in which any suture between cranial bones is generated and organized.
embryonic hindlimb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal.
embryonic limb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.
epithelial cell apoptotic process Any apoptotic process in an epithelial cell.
fibroblast growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
mesenchymal cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
odontogenesis of dentin-containing tooth The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.
positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of stem cell proliferation Any process that activates or increases the frequency, rate or extent of stem cell proliferation.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of endothelial cell chemotaxis to fibroblast growth factor Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
somatic stem cell population maintenance Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
stem cell population maintenance The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
stem cell proliferation The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.

28 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P48801 FGF3 Fibroblast growth factor 3 Gallus gallus (Chicken) SS
Q9NP95 FGF20 Fibroblast growth factor 20 Homo sapiens (Human) SS
Q9HCT0 FGF22 Fibroblast growth factor 22 Homo sapiens (Human) SS
P10767 FGF6 Fibroblast growth factor 6 Homo sapiens (Human) SS
O15520 FGF10 Fibroblast growth factor 10 Homo sapiens (Human) SS
Q92914 FGF11 Fibroblast growth factor 11 Homo sapiens (Human) SS
P11487 FGF3 Fibroblast growth factor 3 Homo sapiens (Human) SS
P31371 FGF9 Fibroblast growth factor 9 Homo sapiens (Human) EV
O43320 FGF16 Fibroblast growth factor 16 Homo sapiens (Human) EV SS
Q9NSA1 FGF21 Fibroblast growth factor 21 Homo sapiens (Human) PR
P08620 FGF4 Fibroblast growth factor 4 Homo sapiens (Human) PR
O35565 Fgf10 Fibroblast growth factor 10 Mus musculus (Mouse) SS
P21658 Fgf6 Fibroblast growth factor 6 Mus musculus (Mouse) SS
P54130 Fgf9 Fibroblast growth factor 9 Mus musculus (Mouse) SS
Q9ESL8 Fgf16 Fibroblast growth factor 16 Mus musculus (Mouse) SS
Q9ESL9 Fgf20 Fibroblast growth factor 20 Mus musculus (Mouse) SS
Q9ESS2 Fgf22 Fibroblast growth factor 22 Mus musculus (Mouse) SS
Q9JJN1 Fgf21 Fibroblast growth factor 21 Mus musculus (Mouse) PR
P61329 Fgf12 Fibroblast growth factor 12 Mus musculus (Mouse) PR
P05524 Fgf3 Fibroblast growth factor 3 Mus musculus (Mouse) SS
Q95L12 FGF9 Fibroblast growth factor 9 Sus scrofa (Pig) SS
Q9EST9 Fgf20 Fibroblast growth factor 20 Rattus norvegicus (Rat) SS
O54769 Fgf16 Fibroblast growth factor 16 Rattus norvegicus (Rat) SS
P36364 Fgf9 Fibroblast growth factor 9 Rattus norvegicus (Rat) SS
P70492 Fgf10 Fibroblast growth factor 10 Rattus norvegicus (Rat) SS
Q6PBT8 fgf1 Putative fibroblast growth factor 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q2HXK8 fgf16 Fibroblast growth factor 16 Danio rerio (Zebrafish) (Brachydanio rerio) SS
P48802 fgf3 Fibroblast growth factor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAKRGPTTGT LLPRVLLALV VALADRGTAA PNGTRHAELG HGWDGLVARS LARLPVAAQP
70 80 90 100 110 120
PQAAVRSGAG DYLLGLKRLR RLYCNVGIGF HLQVLPDGRI GGVHADTRDS LLELSPVQRG
130 140 150 160 170 180
VVSIFGVASR FFVAMSSRGK LFGVPFFTDE CKFKEILLPN NYNAYESYAY PGMFMALSKN
190 200
GRTKKGNRVS PTMKVTHFLP RL