AiPD: Autoinhibited Protein Database

P11277

Gene name	SPTB (SPTB1)
Protein name	Spectrin beta chain, erythrocytic
Names	Beta-I spectrin
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6710
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2075-2137 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

2075-2137 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for P11277

Entry ID	Method	Resolution	Chain	Position	Source
1S35	X-ray	240 A	A	1063-1275	PDB
3EDU	X-ray	210 A	A	1692-1907	PDB
3F57	X-ray	290 A	A/B	1686-1907	PDB
3KBT	X-ray	275 A	A/B	1583-1906	PDB
3KBU	X-ray	275 A	A/B	1583-1906	PDB
3LBX	X-ray	280 A	B	1902-2084	PDB
AF-P11277-F1	Predicted				AlphaFoldDB

1730 variants for P11277

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs121918651 RCV000013693 RCV001000731 RCV001781258	1	M>V	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinVar dbSNP
rs753928319 CA7231565 RCV000355095 RCV000297871	6	E>D	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001753775 RCV001329812 rs138437526 RCV000263879 RCV000356316 CA7231564	9	N>T	Elliptocytosis 3 Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000290958 RCV000383070 CA7231512 rs757763783	74	R>H	Variant assessed as Somatic; 0.0 impact. Spherocytosis, Dominant [NCI-TCGA, ClinVar]	Yes	ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs2082930394 RCV001812264 RCV001262268	138	I>T	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinVar dbSNP
rs121918646 VAR_001352 CA122736 RCV000013684	202	W>R	Hereditary spherocytosis type 2 SPH2; spectrin Kissimmee [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
rs1555371769 RCV003133483 RCV000655908 CA390031881	216	R>Q	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
CA7231385 RCV000403154 COSM1370636 rs764534275 RCV000306714	216	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine Spherocytosis, Dominant [NCI-TCGA, Cosmic, ClinVar]	Yes	ClinGen cosmic curated ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
RCV000352235 RCV002520912 CA7231326 RCV000406739 rs138841945	258	T>M	Spherocytosis, Dominant Variant assessed as Somatic; 0.0007865 impact. Inborn genetic diseases [ClinVar, NCI-TCGA]	Yes	ClinGen ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
RCV001810559 rs143599352 CA7231311 RCV001336807	291	G>S	Elliptocytosis 3 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA10635092 RCV000373860 RCV000321491 rs886050627	314	L>V	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs146651264 CA7231269 RCV000282927 RCV000379719	316	T>I	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs141973081 CA7231248 RCV000329227 RCV000362952	350	V>M	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7231162 RCV000405894 RCV000311567 rs780179918	429	R>Q	Variant assessed as Somatic; 0.0 impact. Spherocytosis, Dominant [NCI-TCGA, ClinVar]	Yes	ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
CA7231158 rs149521594 RCV000298689 RCV001812817 RCV000369811	435	E>Q	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000338831 RCV000243276 RCV001808673 VAR_001353 RCV000391473 RCV001640502 CA7231156 rs229587	439	S>N	Hereditary spherocytosis type 2 Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000391465 RCV000281463 COSM171755 RCV003137921 rs752079707 CA7231152	443	R>H	large_intestine Spherocytosis, Dominant [Cosmic, ClinVar]	Yes	ClinGen cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
RCV000655907 rs1555370967	444	L>missing	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinVar dbSNP
RCV000340064 RCV000287358 COSM106657 rs150698819 CA7231132	448	D>N	Spherocytosis, Dominant skin [ClinVar, Cosmic]	Yes	ClinGen cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
RCV000382998 CA7231103 RCV001329810 RCV000291040 RCV002261046 rs140796444	498	R>H	Spherocytosis, Dominant Pyropoikilocytosis, hereditary [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001002601 rs755636829 RCV000273442 RCV000330884 CA7231096 RCV003137920	502	R>C	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs886050625 RCV002522315 RCV000354950 CA10640616 RCV000260602	521	R>C	Spherocytosis, Dominant Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
CA7231079 rs145315673 RCV000403028 RCV000300035	526	T>I	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000303487 RCV000358248 rs145675502 RCV001329811 RCV001812815 CA7231074	536	D>N	Elliptocytosis 3 Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7231024 RCV000408007 RCV002520911 rs61459051 RCV000306950	589	A>T	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000385612 RCV000349718 CA10645723 rs886050623	599	G>E	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV000251527 RCV001812688 RCV000295049 VAR_038514 rs3742601 RCV000389341 CA7230994	613	S>I	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs863223304 RCV000013694	638	R>missing	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinVar dbSNP
RCV000243750 rs3742602 RCV000304071 RCV001812689 RCV000267682 CA7230958 COSM1607859	687	R>H	liver Spherocytosis, Dominant [Cosmic, ClinVar]	Yes	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs755434241 RCV000307726 CA7230947 RCV000362442	703	M>T	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
rs184962510 CA7230944 RCV001859879 RCV000349076 RCV000403276	706	R>C	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000393004 rs538347576 RCV003137919 RCV000312823 CA7230932	717	R>C	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs867858924 RCV000373232 RCV000337297 CA10640611	730	D>N	Spherocytosis, Dominant Variant assessed as Somatic; impact. [ClinVar, NCI-TCGA]	Yes	ClinGen ClinVar Ensembl NCI-TCGA dbSNP
RCV000322302 RCV000267188 CA7230900 rs147712872 RCV001812812	768	G>D	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV000380614 rs886050621 CA10645713 RCV000326052	807	Q>E	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP
RCV000270879 CA7230869 rs144219025 RCV002520910 RCV000365504	814	R>Q	Spherocytosis, Dominant Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001811601 rs146326769 CA7230848 RCV002249612 RCV001257426	840	R>H	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000313348 RCV000368002 RCV002520909 CA7230823 rs146031194	886	V>L	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1555369657 CA390047744 RCV001784220 RCV000655909	955	R>*	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV003137918 rs764571605 RCV000298942 RCV000404059 CA7230723	993	I>M	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1047765 RCV000392924 CA7230689 RCV000342059	1031	D>Y	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000286900 RCV002261045 RCV000381318 rs143827332 CA7230688	1035	R>W	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000326706 rs374648585 CA7230658 RCV000290473	1104	A>G	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000331133 RCV001812810 RCV000385687 rs141173028 CA7230634	1142	R>Q	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs77806 VAR_001354 RCV001808676 RCV000370587 RCV000251016 RCV000276049 CA7230628 RCV001539178	1151	N>D	Hereditary spherocytosis type 2 Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs76283214 CA7230618 RCV000316138 RCV001507849 RCV001001522 RCV000260948	1160	R>H	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000355761 rs886050620 CA10645701 RCV002522314 RCV000300914	1179	Q>R	Spherocytosis, Dominant Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP
RCV000995192 rs149186357 RCV002249601 CA7230553	1227	P>S	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000984331 rs1594773586	1262	K>missing	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinVar dbSNP
rs150471537 RCV001507847 CA7230456 RCV000655913	1306	R>*	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC dbSNP gnomAD
RCV000766108 rs1566754467 CA390045083	1355	E>*	Hereditary spherocytosis [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
CA7230409 rs199780681 RCV003137917 RCV000332747 RCV000296462	1359	R>Q	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV000387164 RCV001507844 RCV000292952 rs189656371 CA7230410	1359	R>W	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs760803657 CA7230403 RCV001329813 RCV002290996	1369	K>E	Elliptocytosis 3 Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs10132778 CA7230399 RCV000241653 RCV000317379 RCV001812693 VAR_001355 RCV000372015	1374	H>R	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
VAR_001356 RCV000321241 rs17180350 RCV000250003 RCV000266118 RCV001533862 CA7230380	1403	R>Q	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000241782 rs17245552 VAR_038515 RCV000306018 RCV000360695 RCV001707581 CA7230374	1408	G>R	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV002290981 CA390044638 RCV001002577 RCV001784539 rs1594767593 TCGA novel	1423	R>*	Hereditary spherocytosis type 2 Variant assessed as Somatic; impact. [ClinVar, NCI-TCGA]	Yes	ClinGen ClinVar NCI-TCGA Ensembl dbSNP
RCV000313273 CA10640603 rs886050618 RCV000349400	1450	G>V	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV002056405 rs200876438 RCV000349127 CA7230289 RCV000291893	1504	A>V	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV000261981 rs886050617 CA10640601 RCV000354478	1536	D>H	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV000351040 CA7230228 rs760176952 RCV000312530	1551	D>Y	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000283035 CA7230185 rs375478086 RCV000375251	1613	P>S	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs886050615 RCV000307239 CA10635081 RCV000364199	1704	Q>H	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV000284990 CA7230014 rs772761835 RCV000391797	1752	A>G	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001508363 RCV000013696 rs267607086 CA210954	1756	R>*	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
CA7230001 RCV000316717 rs756366285 RCV000373712	1765	A>V	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs200386310 CA7229963 RCV000490389	1819	E>*	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs201267737 CA7229962 RCV002522313 RCV000366566 RCV000328227	1819	E>V	Spherocytosis, Dominant Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV000305906 RCV000507342 RCV002520908 RCV001508362 rs200508249 RCV000397120 CA7229960	1823	D>N	Spherocytosis, Dominant Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000359511 rs886050613 CA10644518 RCV000302354	1844	E>Q	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs1555367359 RCV000655914 CA390040503	1875	Q>*	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
CA7229903 rs148337824 RCV001091049 RCV001329814	1884	A>V	Elliptocytosis 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000350974 CA7229864 rs773780733 RCV000293689	1925	Q>H	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
RCV000290321 RCV000381850 RCV002522312 RCV001812809 rs764560431 CA7229849	1937	S>C	Spherocytosis, Dominant Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001812808 RCV001329815 RCV000268024 RCV000325444 rs140141633 CA7229832	1972	R>Q	Elliptocytosis 3 Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001089553 rs2082214097	2014	F>C	Elliptocytosis 3 [ClinVar]	Yes	ClinVar dbSNP
rs121918647 CA122738 RCV000013686 VAR_001357 RCV000013687	2018	A>G	Elliptocytosis 3 Pyropoikilocytosis, hereditary (hpp) Pyropoikilocytosis, hereditary EL3; Cagliary [ClinVar, Ensembl, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
CA122740 RCV002513020 RCV001004906 VAR_001358 RCV000013688 rs121918648	2019	S>P	Elliptocytosis 3 Hereditary spherocytosis type 2 EL3; Providence [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
rs367841692 VAR_001359 COSM3769482 CA7229762	2023	A>V	pancreas EL3; Paris [Cosmic, UniProt]	Yes	ClinGen cosmic curated UniProt ESP ExAC TOPMed dbSNP gnomAD
CA390039499 rs1225539653 CA390039498 VAR_001360	2024	W>R	EL3; Linguere [UniProt]	Yes	ClinGen UniProt dbSNP gnomAD
COSM1515970 RCV003129752 RCV001004904 VAR_001361 rs121918649 RCV000013691 CA122743	2025	L>R	lung Hereditary spherocytosis type 2 ANEMIA, PERINATAL HEMOLYTIC, FATAL OR NEAR-FATAL EL3; Buffalo [Cosmic, ClinVar, UniProt]	Yes	ClinGen cosmic curated ClinVar UniProt Ensembl dbSNP
CA390039437 RCV000625738 rs1555366607	2032	L>P	Hereditary spherocytosis [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV001089997 rs1345709572	2040	T>I	Hereditary spherocytosis type 2 [ClinVar]	Yes	ClinVar dbSNP
rs863223303 RCV000013682	2046	K>missing	Elliptocytosis 3 [ClinVar]	Yes	ClinVar dbSNP
VAR_001362 rs121918645 RCV001781257 RCV000013679 CA122734	2053	A>P	Elliptocytosis 3 EL3; Kayes [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt ESP ExAC TOPMed dbSNP gnomAD
rs1594753904 RCV000013683	2060	S>missing	Elliptocytosis 3 [ClinVar]	Yes	ClinVar dbSNP
rs1690651311 RCV001329816	2061	W>G	Elliptocytosis 3 [ClinVar]	Yes	ClinVar dbSNP
RCV000013692 CA122745 rs121918650	2064	R>P	Elliptocytosis 3 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000626334 rs1555366592	2066	A>missing	Hereditary spherocytosis [ClinVar]	Yes	ClinVar dbSNP
RCV000349988 rs200787781 RCV003137916 CA7229718 RCV000403325	2079	R>H	Spherocytosis, Dominant [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA262681632 rs372733273 RCV000655915	2091	P>T	Congenital hemolytic anemia [ClinVar]	Yes	ClinGen ClinVar ESP TOPMed dbSNP gnomAD
rs750322310 CA7231568	2	T>A		No	ClinGen ExAC gnomAD
CA390038475 rs1367842585	3	S>L		No	ClinGen gnomAD
CA7231561 rs147059670	14	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1489551959 CA390038394	15	P>R		No	ClinGen gnomAD
rs774891298 CA7231559	18	R>K		No	ClinGen ExAC gnomAD
rs759868093 CA7231560	18	R>W		No	ClinGen ExAC gnomAD
rs771406838 CA7231558	19	I>L		No	ClinGen ExAC TOPMed gnomAD
rs1225208646 CA390038367	19	I>M		No	ClinGen gnomAD
CA7231557 rs761373465	19	I>T		No	ClinGen ExAC gnomAD
CA390038362 rs1306400678	20	N>S		No	ClinGen gnomAD
rs199850904 CA7231556	22	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs200116664 CA7231555	22	R>H		No	ClinGen ExAC TOPMed gnomAD
CA262667774 rs200116664	22	R>L		No	ClinGen ExAC TOPMed gnomAD
CA390038348 rs1302184341	23	W>R		No	ClinGen gnomAD
rs771875005 CA7231552	25	A>S		No	ClinGen ExAC gnomAD
rs771875005 CA7231553	25	A>T		No	ClinGen ExAC gnomAD
rs745686199 CA7231551	25	A>V		No	ClinGen ExAC TOPMed gnomAD
CA7231549 rs369115877	28	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs777962458 CA7231547	29	E>K		No	ClinGen ExAC gnomAD
CA7231543 rs767892082	34	N>S		No	ClinGen ExAC gnomAD
rs375967688 CA390038238	38	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs527744961 CA7231540	39	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1351487127 CA390038201	44	R>Q		No	ClinGen TOPMed gnomAD
rs1228690182 CA390038202	44	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7231537 rs768103906	45	I>L		No	ClinGen ExAC gnomAD
CA262667740 rs1024996523	45	I>M		No	ClinGen TOPMed gnomAD
CA390038185 rs1336011098	47	A>T		No	ClinGen TOPMed
CA390036257 rs1157089669	51	E>G		No	ClinGen TOPMed gnomAD
rs751809792 CA7231523	51	E>K		No	ClinGen ExAC
CA390036255 rs1157089669	51	E>V		No	ClinGen TOPMed gnomAD
RCV001002390 CA390036241 rs1452760098	52	R>L		No	ClinGen ClinVar dbSNP gnomAD
RCV000756716 CA390036242 rs1452760098	52	R>Q		No	ClinGen ClinVar dbSNP gnomAD
RCV001027528 rs1594796374 CA390036247	52	R>W		No	ClinGen ClinVar Ensembl dbSNP
rs191611922 CA262658556	59	T>I		No	ClinGen 1000Genomes
CA390036162 rs1594796364	59	T>P		No	ClinGen Ensembl
CA7231521 rs532240291	61	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1428890712 CA390036127	64	V>M		No	ClinGen TOPMed
CA390036117 rs1594796326	65	N>T		No	ClinGen Ensembl
CA390036110 rs1242475998	66	S>L		No	ClinGen TOPMed gnomAD
rs1242475998 CA390036108	66	S>W		No	ClinGen TOPMed gnomAD
CA390036104 rs1594796304	67	H>P		No	ClinGen Ensembl
rs760171132 CA7231518	67	H>Q		No	ClinGen ExAC gnomAD
CA262658548 rs767062363	69	A>D		No	ClinGen ExAC gnomAD
rs1204232304 CA390036093	69	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1204232304 CA390036095	69	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7231516 rs767062363	69	A>V		No	ClinGen ExAC gnomAD
RCV001812372 CA390036090 rs1566775577	70	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ClinVar Ensembl NCI-TCGA dbSNP
CA390036088 rs1293036930	70	R>P		No	ClinGen gnomAD
CA390036089 rs1293036930	70	R>Q		No	ClinGen gnomAD
CA7231515 rs199910491	71	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774078629 CA7231514	72	S>P		No	ClinGen ExAC gnomAD
rs575005279 CA7231513	74	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA7231510 rs769910649	75	I>V		No	ClinGen ExAC gnomAD
COSM957080 rs781066541 CA7231508	77	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs747147135 CA7231506	80	K>E		No	ClinGen ExAC TOPMed gnomAD
CA7231503 rs750849788	83	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs758726427 CA7231504	83	R>W		No	ClinGen ExAC TOPMed gnomAD
COSM194079 CA390035955 rs1407023521	86	R>C	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA7231502 COSM1370638 rs200814297	86	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA7231501 rs757698672	87	M>V		No	ClinGen ExAC gnomAD
rs1594796144 CA390035823	94	V>G		No	ClinGen Ensembl
rs754403061 CA7231500	98	E>D		No	ClinGen ExAC gnomAD
rs1173811332 CA390035453	101	P>A		No	ClinGen gnomAD
CA390035401 rs1468904056	102	K>M		No	ClinGen TOPMed gnomAD
rs761715254 CA7231474	104	T>S		No	ClinGen ExAC
rs768703842 CA7231472	107	K>N		No	ClinGen ExAC gnomAD
CA7231473 rs376388962	107	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs139094636 COSM1477703 CA7231471	109	R>C	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA7231469 rs772172809	109	R>H		No	ClinGen ExAC gnomAD
CA7231470 rs772172809	109	R>L		No	ClinGen ExAC gnomAD
rs1285245929 CA390035134	112	C>F		No	ClinGen TOPMed gnomAD
CA7231464 rs778131856	118	K>R		No	ClinGen ExAC gnomAD
rs1278859505 CA390035021	119	A>S		No	ClinGen gnomAD
CA262657409 rs1027165019	120	L>F		No	ClinGen Ensembl
rs756588085 CA7231463	124	K>R		No	ClinGen ExAC TOPMed gnomAD
CA7231462 rs371715699	127	R>C		No	ClinGen ESP ExAC gnomAD
CA7231461 rs779669473	127	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs897283858 CA262657394	133	M>T		No	ClinGen Ensembl
rs11623956 CA7231459	136	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1566774323 CA390034668	137	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1406317876 CA390034534	143	H>N		No	ClinGen gnomAD
CA390034516 rs1158489255	143	H>Q		No	ClinGen TOPMed gnomAD
rs547207486 CA7231456	144	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM176865 CA390034501 rs1245522195	144	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs2082929857 RCV001812430	148	G>D		No	ClinVar dbSNP
CA390034450 rs1460952313	148	G>S		No	ClinGen gnomAD
CA7231453 rs775430901	156	R>C		No	ClinGen ExAC TOPMed gnomAD
rs767566180 COSM3401412 CA7231452	156	R>H	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA390032994 rs1301821602	162	I>L		No	ClinGen gnomAD
rs1301821602 CA390032992	162	I>V		No	ClinGen gnomAD
CA7231424 rs773327035	164	V>I		No	ClinGen ExAC gnomAD
CA390032915 rs1413773421	165	Q>H		No	ClinGen TOPMed
CA262656394 rs370778123	170	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA7231422 rs745450272	170	R>H		No	ClinGen ExAC TOPMed gnomAD
rs370778123 CA390032817	170	R>S		No	ClinGen ESP TOPMed gnomAD
rs777269456 CA7231421	172	T>I		No	ClinGen ExAC TOPMed gnomAD
CA390032789 rs1423149594	172	T>P		No	ClinGen gnomAD
rs769340592 CA7231420	173	R>C		No	ClinGen ExAC TOPMed gnomAD
rs146355737 CA7231417 COSM3386637	173	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs146355737 CA7231418	173	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs146355737 CA7231419	173	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1221464632 CA390032731	174	S>L		No	ClinGen TOPMed gnomAD
CA262656368 rs1021832540	180	L>M		No	ClinGen TOPMed gnomAD
CA390032447 rs1217589697	185	M>K		No	ClinGen TOPMed
rs777334501 CA7231415	186	K>R		No	ClinGen ExAC gnomAD
CA7231414 rs184200762	187	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA390032390 rs1192490558	188	A>S		No	ClinGen TOPMed
CA7231396 rs369779185	190	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs747805892 CA7231395	191	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA390032189 rs866674387	192	H>P		No	ClinGen TOPMed gnomAD
CA262656056 rs866674387	192	H>R		No	ClinGen TOPMed gnomAD
rs1566772668 CA390032084	200	S>C		No	ClinGen Ensembl
CA7231393 rs754789252	202	W>L		No	ClinGen ExAC TOPMed gnomAD
rs74666863 CA390032047	203	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7231391 rs144388267	204	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs765367830 CA7231388	210	A>S		No	ClinGen ExAC gnomAD
rs762057472 CA7231387	211	L>V		No	ClinGen ExAC gnomAD
CA390031929 rs1353549870	213	H>Y		No	ClinGen gnomAD
rs754140720 CA7231386	215	H>Q		No	ClinGen ExAC
CA390031024 rs1186772948	218	D>E		No	ClinGen TOPMed
CA7231362 rs200062689	218	D>N	Variant assessed as Somatic; 0.0006492 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1566772276 CA390031000 RCV000761884	219	L>P		No	ClinGen ClinVar Ensembl dbSNP
rs542040700 CA262655613	219	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA390030985 rs1369788122	220	I>M		No	ClinGen TOPMed
CA7231359 rs768355411	221	D>N		No	ClinGen ExAC gnomAD
CA390030910 rs1314374830	223	D>G		No	ClinGen TOPMed
CA262655600 rs200628112	229	N>S		No	ClinGen Ensembl
CA390030746 rs1289830655	231	R>Q		No	ClinGen TOPMed gnomAD
CA7231354 rs138253722	231	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA390030722 rs1256386270	235	E>K		No	ClinGen gnomAD
CA7231351 rs540089964	237	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs756224667 CA7231350	239	N>S		No	ClinGen ExAC gnomAD
rs1010852820 CA262655552	241	A>S		No	ClinGen TOPMed
rs752995009 CA7231349 COSM303293	243	R>C	liver central_nervous_system Variant assessed as Somatic; 4.631e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs767726807 CA7231348	243	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1169509545 CA390030647	246	G>D		No	ClinGen gnomAD
rs147062348 CA7231347	247	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1485478824 CA390030626	249	P>L		No	ClinGen TOPMed
CA390030608 rs1594791834	252	D>A		No	ClinGen Ensembl
CA390030606 rs1246616403	252	D>E		No	ClinGen gnomAD
CA390030603 rs1183242252	253	P>S		No	ClinGen gnomAD
CA390030567 rs1461856269	256	V>I		No	ClinGen gnomAD
rs750955903 CA7231324	259	E>G		No	ClinGen ExAC gnomAD
rs267604024 CA262655174 COSM135653	259	E>K	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs763460080 CA7231323	260	N>D		No	ClinGen ExAC gnomAD
CA7231322 rs760278236	263	E>K		No	ClinGen ExAC gnomAD
CA7231321 rs752289369	267	I>L		No	ClinGen ExAC gnomAD
rs752289369 CA390030493	267	I>V		No	ClinGen ExAC gnomAD
CA262655152 rs1054520140	275	H>Q		No	ClinGen TOPMed gnomAD
CA7231319 rs759127935	276	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs759127935 CA390030428	276	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA262655138 rs776564000 COSM957078	277	F>L	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
rs778701629 COSM3386635 CA7231318	278	S>F	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA7231317 rs770880582	279	K>R		No	ClinGen ExAC gnomAD
rs762936267 CA390030405	280	M>L		No	ClinGen ExAC gnomAD
rs1204218223 CA390030402	280	M>R		No	ClinGen TOPMed
rs1204218223 CA390030403	280	M>T		No	ClinGen TOPMed
rs762936267 CA7231316	280	M>V		No	ClinGen ExAC gnomAD
CA7231315 rs151022993	282	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7231314 rs151022993	282	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1566771680 CA390030381	284	A>T		No	ClinGen Ensembl
CA390030371 rs1486458426	285	V>A		No	ClinGen TOPMed
rs748325242 CA7231313	285	V>M		No	ClinGen ExAC gnomAD
rs1179544605 CA390030348	289	R>C		No	ClinGen TOPMed
CA7231284 rs749794973	295	D>A		No	ClinGen ExAC gnomAD
rs771520744 CA7231283 CA262654484	295	D>E		No	ClinGen ExAC gnomAD
CA7231282 rs754585879	296	H>Y		No	ClinGen ExAC gnomAD
CA262654477 rs1002035329	298	I>T		No	ClinGen Ensembl
rs1594790275 CA390030144	298	I>V		No	ClinGen Ensembl
rs1594790255 RCV001000873	301	E>missing		No	ClinVar dbSNP
CA262654464 rs967975857	302	K>E		No	ClinGen gnomAD
rs748115462 CA262654457	302	K>M		No	ClinGen Ensembl
rs967975857 CA390030073	302	K>Q		No	ClinGen gnomAD
CA7231281 rs368472797	303	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA262654455 rs1022539299	303	M>K		No	ClinGen TOPMed
CA390030047 rs1022539299	303	M>T		No	ClinGen TOPMed
rs766203211 CA7231280	305	E>K		No	ClinGen ExAC TOPMed gnomAD
rs892191009 CA262654431	307	Y>C		No	ClinGen Ensembl
rs559699714 CA262654440	307	Y>H		No	ClinGen Ensembl
rs568301999 CA7231278	308	S>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1434727098 CA390029965	309	G>A		No	ClinGen TOPMed gnomAD
rs199658725 CA7231275	309	G>R		No	ClinGen ExAC TOPMed gnomAD
rs199658725 CA7231276	309	G>W		No	ClinGen ExAC TOPMed gnomAD
rs764135314 CA7231274	311	A>T		No	ClinGen ExAC gnomAD
CA7231272 rs775682407	312	S>L		No	ClinGen ExAC gnomAD
rs1387815749 CA390029926	313	D>E		No	ClinGen gnomAD
CA390029943 rs1196226577	313	D>N		No	ClinGen gnomAD
CA7231270 rs746095514	314	L>P		No	ClinGen ExAC gnomAD
CA390029919 rs746095514	314	L>R		No	ClinGen ExAC gnomAD
rs1566770865 CA390029882	317	W>L		No	ClinGen Ensembl
CA262654361 COSM957076 rs1024800811	319	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs202239352 CA7231267	322	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1374707569 CA390029614	323	T>I		No	ClinGen gnomAD
rs1424410096 CA390029585	324	V>A		No	ClinGen gnomAD
rs1333389950 CA390029599	324	V>I		No	ClinGen gnomAD
CA7231264 RCV001812968 rs143293179	328	R>C	Variant assessed as Somatic; 9.24e-05 impact. [NCI-TCGA]	No	ClinGen ClinVar 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs779720812 CA7231263	328	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1175103350 CA390029315	332	N>S		No	ClinGen gnomAD
CA7231261 rs750069570	333	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7231259 rs200381147	335	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1205242254 CA390029197	336	G>D		No	ClinGen gnomAD
rs1197265603 CA390029165	337	V>A		No	ClinGen gnomAD
rs1009915997 COSM433257 CA262654244	337	V>I	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA7231255 rs149837193	343	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1238023863 CA390028901	345	S>C		No	ClinGen TOPMed gnomAD
CA390028879 rs1376322051	346	T>I		No	ClinGen gnomAD
CA390028888 rs1594789979	346	T>P		No	ClinGen Ensembl
CA390028880 rs1376322051	346	T>S		No	ClinGen gnomAD
CA7231252 rs139871838	348	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7231253 rs139871838	348	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7231251 rs373606427	348	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA7231250 rs763297500	349	T>I		No	ClinGen ExAC gnomAD
rs1355427206 CA390028711	352	K>N		No	ClinGen TOPMed
CA7231247 rs748666173	353	P>L		No	ClinGen ExAC gnomAD
CA7231245 rs771726421	354	P>L		No	ClinGen ExAC TOPMed gnomAD
CA390028678 rs1566770599	354	P>S		No	ClinGen Ensembl
CA390027165 rs1211685510	358	E>D		No	ClinGen TOPMed gnomAD
rs376523884 CA7231222	362	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA7231221 rs749002006	362	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA390027033 rs1594787727	365	L>R		No	ClinGen Ensembl
CA390026982 rs1594787713	368	T>P		No	ClinGen Ensembl
rs752604792 CA7231218	369	I>F		No	ClinGen ExAC gnomAD
CA390026936 rs1594787698	370	Q>K		No	ClinGen Ensembl
rs781176597 CA7231217	370	Q>R		No	ClinGen ExAC gnomAD
rs200215995 CA7231216	372	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1019802326 CA262651986	372	R>W		No	ClinGen TOPMed
CA390026855 rs1167992290	373	M>I		No	ClinGen gnomAD
rs1466812782 CA390026849	374	R>G		No	ClinGen TOPMed gnomAD
RCV001000816 CA390026837 rs1594787664	374	R>S		No	ClinGen ClinVar Ensembl dbSNP
CA390026827 rs1378864273	375	A>P		No	ClinGen TOPMed gnomAD
rs766483443 CA7231214	375	A>V		No	ClinGen ExAC TOPMed gnomAD
CA7231213 rs763042691	377	N>H		No	ClinGen ExAC TOPMed gnomAD
CA390026703 rs1449934124	381	Y>H		No	ClinGen gnomAD
CA390026658 rs1266679700	383	P>L		No	ClinGen gnomAD
CA7231211 COSM338999 rs762308704	384	H>Q	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA390026655 rs1199372701	384	H>Y		No	ClinGen gnomAD
CA7231208 rs764565903	385	D>E		No	ClinGen ExAC gnomAD
rs777273263 CA390026632	385	D>H		No	ClinGen ExAC TOPMed gnomAD
rs777273263 CA7231209	385	D>N		No	ClinGen ExAC TOPMed gnomAD
CA7231207 rs761256991	386	G>A		No	ClinGen ExAC TOPMed gnomAD
CA390026613 rs761256991	386	G>E		No	ClinGen ExAC TOPMed gnomAD
rs773696890 CA7231206	389	V>A		No	ClinGen ExAC
rs1276536864 CA390026543	390	S>C		No	ClinGen gnomAD
CA7231205 rs770497779	392	I>T		No	ClinGen ExAC gnomAD
rs982432003 CA262651926	392	I>V		No	ClinGen TOPMed
CA262651901 rs954194255	393	N>S		No	ClinGen gnomAD
rs748918482 CA7231204	394	R>T		No	ClinGen ExAC gnomAD
rs768515967 CA7231182	395	A>D		No	ClinGen ExAC TOPMed gnomAD
CA390025381 rs1266357450	395	A>T		No	ClinGen TOPMed
rs768515967 CA7231183	395	A>V		No	ClinGen ExAC TOPMed gnomAD
rs746893701 CA7231181	402	A>T		No	ClinGen ExAC gnomAD
rs780076416 CA7231180	402	A>V		No	ClinGen ExAC gnomAD
CA390025215 rs1473222862	404	Y>C		No	ClinGen TOPMed gnomAD
rs372478057 CA7231179	405	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA262651032 rs994269978	405	R>W		No	ClinGen TOPMed gnomAD
CA7231177 rs147447737	406	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs779318405 CA7231178	406	R>W		No	ClinGen ExAC TOPMed gnomAD
CA7231176 rs200997767	407	E>G		No	ClinGen ExAC gnomAD
CA262650984 rs78857753	408	L>V		No	ClinGen Ensembl
CA390025161 rs1228426511	409	A>V		No	ClinGen gnomAD
rs764345236 CA7231174	410	L>M		No	ClinGen ExAC
CA262650963 rs1045761828	410	L>P		No	ClinGen Ensembl
rs868858742 CA262650956	411	R>K		No	ClinGen Ensembl
rs950142836 CA262650952	412	N>I		No	ClinGen TOPMed gnomAD
CA7231172 rs753141325	416	R>Q		No	ClinGen ExAC
rs756541394 CA7231173	416	R>W	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs749872891 CA7231169	421	E>G		No	ClinGen ExAC gnomAD
CA7231170 rs142982338	421	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA390025036 rs749872891	421	E>V		No	ClinGen ExAC gnomAD
CA390025032 rs1307268322	422	Q>E		No	ClinGen TOPMed
rs764755827 CA7231168	423	L>V		No	ClinGen ExAC
CA7231165 rs374066115	425	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7231166 COSM470130 rs200818459	425	R>W	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA7231164 rs557868487	426	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs977348778 CA262650888	426	R>H		No	ClinGen gnomAD
rs977348778 CA262650887	426	R>P		No	ClinGen gnomAD
rs775276485 CA390024953	429	R>W		No	ClinGen ExAC gnomAD
CA390024890 rs1195596537	431	A>S		No	ClinGen TOPMed gnomAD
CA390024882 rs1285270460	432	A>T	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA262650814 rs867629503	433	M>I		No	ClinGen Ensembl
CA7231159 rs143289471	433	M>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs779089363 CA7231160	433	M>V		No	ClinGen ExAC gnomAD
CA262650803 rs953282126	436	T>S		No	ClinGen Ensembl
CA7231155 CA390024730 rs753052140	439	S>R		No	ClinGen ExAC gnomAD
rs781543548 CA7231154	442	Q>R		No	ClinGen ExAC gnomAD
CA7231153 COSM1227457 rs372278924	443	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1594786052 CA390024628	445	V>M		No	ClinGen Ensembl
CA390024606 rs1162777186	446	A>V		No	ClinGen gnomAD
rs755750964 CA7231130	448	D>G		No	ClinGen ExAC gnomAD
CA7231131 rs150698819	448	D>H		No	ClinGen ExAC TOPMed gnomAD
CA7231129 rs752448028	450	F>S		No	ClinGen ExAC
CA7231127 rs759470847	451	G>V		No	ClinGen ExAC TOPMed gnomAD
CA390024299 rs1594785227	453	D>A		No	ClinGen Ensembl
CA390024295 rs200407185	453	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs568264177 CA7231126	453	D>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs576643197 CA262649984	456	A>S		No	ClinGen TOPMed gnomAD
CA390024229 rs1594785207	457	V>G		No	ClinGen Ensembl
CA7231122 rs377510670	460	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1594785199 CA390024188	461	K>Q		No	ClinGen Ensembl
rs748376558 CA7231121	461	K>R		No	ClinGen ExAC TOPMed gnomAD
CA7231120 rs373287476	462	K>N		No	ClinGen ESP ExAC gnomAD
CA390024138 rs1173000675	464	H>Y		No	ClinGen gnomAD
CA262649941 rs1034917443	467	I>V		No	ClinGen gnomAD
CA390024085 rs1418100152	468	E>K		No	ClinGen gnomAD
CA7231116 rs758872603	470	D>N		No	ClinGen ExAC gnomAD
rs746390869 CA7231115	471	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1594785170 CA390024048	471	T>P		No	ClinGen Ensembl
CA390024017 rs1566766968	473	A>V		No	ClinGen Ensembl
CA262649911 rs778518936	474	Y>C		No	ClinGen Ensembl
rs200071450 CA7231112	475	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1288189443 CA390023989	476	E>*		No	ClinGen gnomAD
CA390023991 rs1288189443	476	E>K		No	ClinGen gnomAD
CA390023984 rs1238093921	476	E>V		No	ClinGen gnomAD
rs767337494 CA7231111	477	R>Q		No	ClinGen ExAC
CA390023959 rs1594785116	478	V>G		No	ClinGen Ensembl
rs1594785122 CA390023968	478	V>M		No	ClinGen Ensembl
CA390023957 rs1335363319	479	R>G		No	ClinGen gnomAD
CA7231110 rs754692333	480	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1377891764 CA390023939	480	A>V		No	ClinGen TOPMed
CA7231109 rs751336266	481	L>V		No	ClinGen ExAC
CA7231108 rs766122956	486	Q>K		No	ClinGen ExAC gnomAD
rs762902447 CA7231107	489	E>K		No	ClinGen ExAC TOPMed gnomAD
CA390023836 rs762902447	489	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs773068965 CA7231106	494	H>Y		No	ClinGen ExAC
CA390023707 rs1312059301	497	K>N		No	ClinGen gnomAD
rs144624027 RCV001812278 CA7231104	498	R>C	Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA]	No	ClinGen ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
CA7231105 rs144624027	498	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7231102 rs768807740	499	I>N		No	ClinGen ExAC gnomAD
CA390023675 rs1325711290	499	I>V		No	ClinGen TOPMed
rs775790438 CA7231100 COSM957074	500	T>A	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs371029401 CA7231099	500	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs550344847 CA7231097	501	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs769871954 CA7231095	502	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs754641316 CA7231093	503	K>E		No	ClinGen ExAC gnomAD
rs751281187 CA7231092	503	K>N		No	ClinGen ExAC gnomAD
CA262649782 rs981578613	505	N>H		No	ClinGen TOPMed
CA7231090 rs377621722	506	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs750365417 COSM2248696 CA7231089	508	R>C	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs142541718 CA7231088	508	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1200072657 CA390023324	511	S>N		No	ClinGen TOPMed
CA390023285 rs753847520	512	Y>C		No	ClinGen ExAC gnomAD
CA7231086 rs753847520	512	Y>F		No	ClinGen ExAC gnomAD
CA390023283 rs753847520	512	Y>S		No	ClinGen ExAC gnomAD
CA390023177 rs1296320449	515	E>D		No	ClinGen gnomAD
CA390023174 rs1381156110	516	L>M		No	ClinGen gnomAD
rs1469177099 CA390023169	516	L>Q		No	ClinGen TOPMed
COSM957073 rs1181994000 CA390023097	520	R>Q	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA7231084 rs760837664	521	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs760837664 COSM315579 CA390023076	521	R>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs772481672 CA7231082	523	R>S		No	ClinGen ExAC TOPMed gnomAD
CA7231080 rs55752508 VAR_061084	525	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen UniProt 1000Genomes ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs55752508 CA262649705	525	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1594784903 CA390022980	527	T>P		No	ClinGen Ensembl
rs969131309 CA262649688	528	L>P		No	ClinGen Ensembl
CA390022963 rs1377106577	529	A>P		No	ClinGen TOPMed
rs780802539 CA7231077	530	L>V		No	ClinGen ExAC gnomAD
rs573438233 CA7231075	535	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758196795 CA7231073	539	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA7231072 rs750124646	540	S>N		No	ClinGen ExAC gnomAD
rs140225792 CA7231070	542	D>N		No	ClinGen ESP ExAC gnomAD
CA390022784 rs1384605202	543	W>R		No	ClinGen gnomAD
rs267604023 CA262649636	544	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1232155679 CA390021864	550	H>L		No	ClinGen TOPMed
rs539283144 CA7231048	550	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA7231047 rs767667413	551	L>F		No	ClinGen ExAC gnomAD
rs368886050 CA7231046	551	L>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA390021836 rs1280642082	552	L>F		No	ClinGen gnomAD
rs376738838 CA7231045	553	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1208559492 CA390021835	553	S>P		No	ClinGen TOPMed gnomAD
rs1003421463 CA262648794	554	A>D		No	ClinGen Ensembl
CA7231044 rs766824367	554	A>T		No	ClinGen ExAC gnomAD
CA390021821 rs1278642208	555	E>D		No	ClinGen gnomAD
CA7231043 rs570709723	555	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA390021811 rs1441917693	557	G>R		No	ClinGen gnomAD
CA390021784 rs1315196865	560	L>F		No	ClinGen gnomAD
rs765778666 CA7231041	562	E>D		No	ClinGen ExAC TOPMed gnomAD
CA7231040 rs762383059	563	V>A		No	ClinGen ExAC TOPMed gnomAD
CA7231038 rs771632136	565	D>E		No	ClinGen ExAC gnomAD
rs556939239 CA7231037	566	L>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs770700837 CA7231035	569	K>E		No	ClinGen ExAC gnomAD
rs1267571960 CA390021676	570	H>Y		No	ClinGen TOPMed
rs777550092 CA7231033	572	L>V		No	ClinGen ExAC gnomAD
CA390021639 rs1485283390	573	M>V		No	ClinGen gnomAD
CA390021602 rs1455343299	575	A>D		No	ClinGen TOPMed
rs144668591 CA7231032	577	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs781111810 CA7231030	578	A>T		No	ClinGen ExAC gnomAD
rs776683477 CA7231029	580	Q>H		No	ClinGen ExAC gnomAD
rs766762166 CA262648693	582	D>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1033968687 CA262648671	583	K>T		No	ClinGen TOPMed gnomAD
CA7231026 rs758702417	584	V>A		No	ClinGen ExAC gnomAD
rs903631784 CA262648643	586	A>T		No	ClinGen Ensembl
CA390021407 rs1343438732	590	A>T		No	ClinGen gnomAD
rs1416270783 CA390021303	595	T>I		No	ClinGen gnomAD
rs759151834 CA7231020	596	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7231019 rs773865584	597	G>E		No	ClinGen ExAC gnomAD
rs748973588 CA7231017	598	K>Q		No	ClinGen ExAC gnomAD
rs765897258 CA7231000	600	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs1018237397 CA262647982	600	Y>F		No	ClinGen gnomAD
CA390021057 rs1196623209	603	C>Y		No	ClinGen TOPMed
rs772895139 CA7230998	605	P>L		No	ClinGen ExAC gnomAD
CA390021012 rs1219878096	605	P>S		No	ClinGen TOPMed gnomAD
rs1301348044 CA390020987	607	V>A		No	ClinGen gnomAD
rs1377963089 CA390020944	610	D>V		No	ClinGen gnomAD
CA7230996 rs761729520	611	R>C		No	ClinGen ExAC TOPMed gnomAD
rs148927610 CA7230995	611	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA262647952 rs148927610	611	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390020912 rs1353840648	613	S>G		No	ClinGen gnomAD
CA262647947 rs1034587612	617	Q>L		No	ClinGen TOPMed
rs1415427504 CA390020816	619	F>I		No	ClinGen TOPMed
rs1439882520 CA390020779	621	E>K		No	ClinGen gnomAD
rs779261630 CA7230989	624	N>D		No	ClinGen ExAC TOPMed gnomAD
CA390020706 rs1328766457 CA390020707	625	M>I		No	ClinGen TOPMed
CA390020719 rs1397944514	625	M>V		No	ClinGen TOPMed
rs757548423 CA7230988	626	A>E		No	ClinGen ExAC gnomAD
rs1594783138 CA390020683	627	A>G		No	ClinGen Ensembl
CA7230987 rs754164238	628	G>R		No	ClinGen ExAC gnomAD
CA7230985 rs375567377	629	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230986 rs778031606	629	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA390020637 rs1278230826	631	A>S		No	ClinGen TOPMed gnomAD
CA390020640 rs1278230826	631	A>T		No	ClinGen TOPMed gnomAD
rs1355258527 CA390020621	632	Q>R		No	ClinGen TOPMed
rs1372257114 CA390020555	637	K>R		No	ClinGen gnomAD
rs371216825 CA262647933 COSM1707463	638	R>Q	skin [Cosmic]	No	ClinGen cosmic curated ESP TOPMed gnomAD
rs1347159378 CA390020524	640	W>R		No	ClinGen gnomAD
rs750065922 CA7230981	642	F>L		No	ClinGen ExAC gnomAD
rs1373593604 CA390020472	643	F>V		No	ClinGen gnomAD
rs764890720 CA7230980	644	W>R		No	ClinGen ExAC gnomAD
rs2082718032 RCV001812455	645	E>*		No	ClinVar dbSNP
CA390020426 rs1316572886	645	E>D		No	ClinGen gnomAD
rs761372149 CA7230978	646	M>T		No	ClinGen ExAC TOPMed gnomAD
CA262647923 rs993529208	650	E>Q		No	ClinGen TOPMed
rs776443913 CA7230977	651	S>G		No	ClinGen ExAC gnomAD
CA390020301 rs1250189126	654	K>E		No	ClinGen gnomAD
CA390020294 rs1189125436	654	K>R		No	ClinGen gnomAD
CA7230975 rs377670964	656	K>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs775607932 CA7230974	657	E>K		No	ClinGen ExAC TOPMed gnomAD
CA390020220 rs1210232258	659	I>F		No	ClinGen gnomAD
CA390020221 rs1210232258	659	I>V		No	ClinGen gnomAD
rs375659876 CA7230973	660	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230972 rs375659876	660	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA262647902 rs1056571409	662	S>Y		No	ClinGen TOPMed
CA390020163 rs1237082371	663	L>P		No	ClinGen gnomAD
rs749496373 CA7230969	664	D>G		No	ClinGen ExAC TOPMed gnomAD
rs141730908 CA7230970	664	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs141730908 CA262647855	664	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs765506008 CA262647854	665	Y>H		No	ClinGen gnomAD
CA262647852 rs995821770	666	G>D		No	ClinGen TOPMed gnomAD
rs900152568 CA262647848	668	D>E		No	ClinGen TOPMed gnomAD
rs778179430 CA7230968	670	T>I		No	ClinGen ExAC gnomAD
rs1286630711 CA390019964	672	V>M		No	ClinGen gnomAD
CA390019882 rs1297984865	675	L>F		No	ClinGen TOPMed
rs1166073457 CA390019865	676	Q>P		No	ClinGen gnomAD
CA390019867 rs1166073457	676	Q>R		No	ClinGen gnomAD
COSM957072 CA7230964 rs755493619	677	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs138774947 CA7230963	677	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs936565423 CA262647780	681	A>D		No	ClinGen TOPMed gnomAD
rs753480687 CA390019583	684	D>E		No	ClinGen ExAC TOPMed gnomAD
rs756881722 CA7230961	684	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1485648469 CA390019593	684	D>V		No	ClinGen gnomAD
CA7230959 rs763916428	687	R>C		No	ClinGen ExAC gnomAD
CA390019469 rs1390983563	690	D>A		No	ClinGen gnomAD
rs868450644 CA262647702	692	H>Q		No	ClinGen Ensembl
rs987994868 CA262647709	692	H>Y		No	ClinGen Ensembl
CA390019325 CA7230953 rs770967001	695	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA7230952 rs749496235	696	I>N		No	ClinGen ExAC
rs1392664372 CA390019320	696	I>V		No	ClinGen TOPMed gnomAD
rs773376094 CA7230951	697	F>S		No	ClinGen ExAC gnomAD
CA7230950 rs770132994	698	Q>R		No	ClinGen ExAC gnomAD
rs748458507 CA7230949	700	A>V		No	ClinGen ExAC gnomAD
rs946135261 CA262647608	701	H>R		No	ClinGen TOPMed gnomAD
CA7230948 rs781545542	701	H>Y		No	ClinGen ExAC gnomAD
rs112923222 CA390019126	705	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1467323426 CA390019138	705	A>T		No	ClinGen gnomAD
rs112923222 CA7230946	705	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM1323429 CA7230942 rs201889680	706	R>H	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs201889680 CA390019110	706	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201889680 CA7230943	706	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1331108244 CA390019086	707	K>N		No	ClinGen TOPMed gnomAD
CA390019056 rs1305006518	708	Q>L		No	ClinGen TOPMed gnomAD
CA390019046 rs776701697	709	F>I		No	ClinGen ExAC TOPMed gnomAD
CA7230941 rs776701697	709	F>V		No	ClinGen ExAC TOPMed gnomAD
CA7230940 rs752501133	710	G>R		No	ClinGen ExAC gnomAD
CA7230938 rs751493156	711	H>Q		No	ClinGen ExAC gnomAD
CA390018953 rs1399245468	712	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs763003753 CA7230935	714	I>M		No	ClinGen ExAC TOPMed gnomAD
CA7230934 rs773358270	715	E>K	Variant assessed as Somatic; 9.246e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA390018894 rs1301121444	716	A>D		No	ClinGen TOPMed
rs769940259 CA7230933	716	A>P		No	ClinGen ExAC gnomAD
rs199594314 CA7230931 COSM3956154	717	R>H	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA390018884 rs199594314	717	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769054911 CA7230930	718	I>L		No	ClinGen ExAC gnomAD
rs769054911 CA390018878	718	I>V		No	ClinGen ExAC gnomAD
rs780490335 CA7230928	719	K>R		No	ClinGen ExAC gnomAD
CA7230927 rs369224543	720	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA390018830 rs1231488517	721	V>L		No	ClinGen TOPMed gnomAD
rs150328574 CA7230925	722	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230923 rs752447945	723	A>P		No	ClinGen ExAC TOPMed gnomAD
CA390018807 rs752447945	723	A>T		No	ClinGen ExAC TOPMed gnomAD
CA390018791 rs1327286039	724	Q>*		No	ClinGen gnomAD
rs781104894 CA7230922	725	W>C		No	ClinGen ExAC gnomAD
CA390018750 rs1175567202	726	D>E		No	ClinGen gnomAD
CA390018759 rs1376630629	726	D>N		No	ClinGen TOPMed gnomAD
CA390018731 rs1432995300	727	Q>H		No	ClinGen gnomAD
rs1594782650 CA390018740	727	Q>P		No	ClinGen Ensembl
rs963622491 CA262647487	729	K>R		No	ClinGen TOPMed gnomAD
CA390018690 rs1159293569	730	D>E		No	ClinGen gnomAD
CA390018685 rs1471286182	731	L>V		No	ClinGen TOPMed gnomAD
CA262647476 rs868474604 COSM140032	732	A>T	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA7230921 RCV000415846 rs772434433	733	A>P		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA7230920 rs751504585	733	A>V		No	ClinGen ExAC
CA390018595 rs1180860976	737	K>N		No	ClinGen TOPMed gnomAD
CA262647467 rs536482067	738	N>S		No	ClinGen 1000Genomes
CA7230919 rs766172170	739	L>F		No	ClinGen ExAC gnomAD
CA390018551 rs1485098539	740	Q>H		No	ClinGen gnomAD
CA390018556 rs1208086065	740	Q>R		No	ClinGen gnomAD
rs1284351415 CA390018548	741	D>H		No	ClinGen gnomAD
CA7230915 rs369831704	743	E>K		No	ClinGen ESP ExAC gnomAD
CA390018467 rs1003635786	746	F>C		No	ClinGen Ensembl
rs1278111786 CA390018475	746	F>L		No	ClinGen gnomAD
CA262647407 rs1003635786	746	F>S		No	ClinGen Ensembl
CA390018439 rs1228210390	748	F>S		No	ClinGen gnomAD
CA7230913 rs769001913	749	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1402625880 CA390018396	751	D>G		No	ClinGen gnomAD
rs775936031 CA7230911	751	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA390018382 rs151164761	752	A>G		No	ClinGen ESP ExAC gnomAD
rs1045108609 CA262647366	752	A>T		No	ClinGen Ensembl
CA7230910 rs151164761	752	A>V		No	ClinGen ESP ExAC gnomAD
rs1475445478 CA390018378	753	D>N		No	ClinGen gnomAD
CA7230908 rs776388224	756	K>E		No	ClinGen ExAC gnomAD
rs1474848178 CA390018284	758	W>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA390018230 rs769469651	760	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA390018222 rs1594782497	761	D>Y		No	ClinGen Ensembl
CA262647338 rs369439568	762	A>S		No	ClinGen ESP TOPMed gnomAD
rs369439568 CA390018199	762	A>T	Variant assessed as Somatic; 9.706e-05 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs1052362411 CA262647330	763	H>L		No	ClinGen Ensembl
CA7230904 rs754670202	764	R>P		No	ClinGen ExAC TOPMed gnomAD
CA7230905 rs754670202	764	R>Q		No	ClinGen ExAC TOPMed gnomAD
RCV000756713 rs376198076 CA262647329	764	R>W		No	ClinGen ClinVar ESP TOPMed dbSNP gnomAD
rs751243495 CA7230903	766	L>F		No	ClinGen ExAC TOPMed
rs779925712 CA7230902	767	S>T		No	ClinGen ExAC
rs757397544 CA7230898	771	V>G		No	ClinGen ExAC gnomAD
rs141749822 CA7230897	772	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA390017983 rs1343640117	772	G>R		No	ClinGen gnomAD
rs1396334985 CA390017968	773	Q>K		No	ClinGen gnomAD
rs1162556241 CA390017948	774	D>V		No	ClinGen gnomAD
CA7230895 rs551791156	775	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA390017919 rs1187745599	777	A>T		No	ClinGen gnomAD
CA390017907 rs1594782394	778	T>A		No	ClinGen Ensembl
rs371595430 CA7230894	778	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230893 rs371595430	778	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs150063025 COSM1266748 CA7230890	779	R>Q	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs200389830 CA7230891	779	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1275392695 CA390017890	780	A>T		No	ClinGen gnomAD
CA7230889 rs747601257	781	L>P		No	ClinGen ExAC gnomAD
CA390017864 rs1216398547	782	G>E		No	ClinGen gnomAD
CA7230888 rs776282987	782	G>R		No	ClinGen ExAC gnomAD
CA7230887 rs768150365	783	K>E		No	ClinGen ExAC TOPMed gnomAD
CA262647277 rs983773153	783	K>R		No	ClinGen gnomAD
CA390017807 rs1357166979	786	K>R		No	ClinGen TOPMed
rs746692205 CA7230886	788	F>L		No	ClinGen ExAC TOPMed gnomAD
CA7230885 rs559474125	796	R>C		No	ClinGen 1000Genomes ExAC gnomAD
COSM247592 CA7230884 rs779141940	796	R>H	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs768427782 CA262647257	797	G>E		No	ClinGen gnomAD
rs778881764 CA7230882 CA390017662	797	G>R		No	ClinGen ExAC gnomAD
CA262647255 rs902395486	800	E>G		No	ClinGen TOPMed gnomAD
CA7230881 rs757201845	801	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA7230880 rs566689631	803	E>*		No	ClinGen ExAC gnomAD
CA7230879 rs546740686	803	E>G		No	ClinGen ExAC gnomAD
CA7230877 rs753002999	804	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1233823929 CA390016624	810	P>L		No	ClinGen gnomAD
CA7230876 rs767767799	810	P>S		No	ClinGen ExAC TOPMed gnomAD
rs140584449 CA7230873	811	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230872 rs144888014	812	E>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230870 rs148718822	814	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230871 rs148718822	814	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230868 rs775282320	815	D>N		No	ClinGen ExAC gnomAD
CA7230867 rs771843664	815	D>V		No	ClinGen ExAC gnomAD
rs778685523 CA7230865	820	T>A		No	ClinGen ExAC gnomAD
CA7230864 rs368515091	820	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230862 rs777683294	821	H>R		No	ClinGen ExAC gnomAD
rs1174835310 CA390016555	822	R>Q		No	ClinGen gnomAD
rs201338747 CA7230861	822	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1409112163 CA390016548	823	L>Q		No	ClinGen gnomAD
rs752847367 CA7230860	824	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA7230858 rs150013838	827	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201451634 CA7230859	827	R>W		No	ClinGen ExAC TOPMed gnomAD
CA7230857 rs751929073	829	L>V		No	ClinGen ExAC gnomAD
CA390016504 rs1486735780	831	Q>E		No	ClinGen gnomAD
rs766869436 CA7230856	831	Q>R		No	ClinGen ExAC
rs1594782154 CA390016486	833	V>G		No	ClinGen Ensembl
CA7230855 rs763528404	833	V>M		No	ClinGen ExAC gnomAD
CA390016482 rs1308836800	834	V>E		No	ClinGen TOPMed gnomAD
CA390016480 rs1308836800	834	V>G		No	ClinGen TOPMed gnomAD
rs139325158 CA7230853	837	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs139325158 CA7230852	837	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs759218961 COSM194076 CA7230849	840	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA7230847 rs770752260	844	L>P		No	ClinGen ExAC gnomAD
CA390016413 rs1161709794	845	Q>R		No	ClinGen gnomAD
RCV001290763 rs2082703730	847	A>missing		No	ClinVar dbSNP
CA390016396 rs1215505905	847	A>V		No	ClinGen Ensembl
CA390016378 rs1471849890	850	L>P		No	ClinGen gnomAD
rs370204007 CA262647087	851	Y>C		No	ClinGen ESP TOPMed
rs753867736 CA262647056 COSM1227462	852	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA262647063 rs753867736	852	T>R		No	ClinGen TOPMed gnomAD
rs1254118286 CA390016362	853	V>L		No	ClinGen gnomAD
rs12433436 CA390016352	854	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748190264 CA7230842 CA390016350	855	G>R		No	ClinGen ExAC TOPMed gnomAD
rs755198398 CA7230840	856	E>K		No	ClinGen ExAC TOPMed
CA390016332 rs1328144787	857	T>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1054843687 CA262647031	858	D>N		No	ClinGen TOPMed
rs942424375 COSM1177615 CA262647018	859	A>T	large_intestine Variant assessed as Somatic; impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1235010327 CA390016320	859	A>V		No	ClinGen TOPMed gnomAD
CA7230839 rs780538811	861	E>D		No	ClinGen ExAC TOPMed gnomAD
CA390016282 rs750883612 CA7230836	864	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1363623560 CA390016288	864	M>V		No	ClinGen TOPMed gnomAD
CA7230835 rs567473643	865	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs762232792 CA7230834	869	K>E		No	ClinGen ExAC
CA390016237 rs1388294619	870	W>C		No	ClinGen TOPMed gnomAD
rs1171931483 CA390016236	871	L>M		No	ClinGen TOPMed
CA7230833 rs752212117	873	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA390016200 rs1298161867	876	M>V		No	ClinGen gnomAD
rs770698912 CA7230829	880	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs762750732 CA7230827	881	E>K		No	ClinGen ExAC
rs918255341 CA262646978	882	D>G		No	ClinGen TOPMed
CA262646984 rs181243939	882	D>N		No	ClinGen 1000Genomes
CA7230826 rs772885580	883	L>V		No	ClinGen ExAC gnomAD
rs1594781923 CA390015816	885	V>G		No	ClinGen Ensembl
rs146031194 CA7230824	886	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230821 rs747235133	887	Q>H		No	ClinGen ExAC gnomAD
CA262646963 rs868238812	887	Q>R		No	ClinGen Ensembl
CA390015775 rs1354144509	888	H>Q		No	ClinGen gnomAD
CA390015783 rs1226990297	888	H>R		No	ClinGen TOPMed
CA7230820 rs780485535	888	H>Y		No	ClinGen ExAC gnomAD
rs758566525 CA7230819	889	R>K		No	ClinGen ExAC gnomAD
CA7230800 rs779314843	890	F>L		No	ClinGen ExAC gnomAD
CA7230798 rs749781587	891	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1566762838 CA390015664	894	D>Y		No	ClinGen Ensembl
rs980370978 CA262646224	896	E>K		No	ClinGen TOPMed
CA390015601 rs1376811028	897	M>I		No	ClinGen gnomAD
CA7230796 rs376848372	897	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs373593599 CA7230795	899	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390015540 rs1439464736	902	T>I		No	ClinGen gnomAD
rs746868966 CA262646192	903	Q>H		No	ClinGen Ensembl
CA390015528 rs1249597109	904	I>T		No	ClinGen gnomAD
rs765893110 CA7230794	906	G>D		No	ClinGen ExAC gnomAD
CA7230793 rs758045310	907	V>A		No	ClinGen ExAC gnomAD
CA390015506 rs1306830178	908	N>D		No	ClinGen gnomAD
rs750079421 RCV000761883 CA7230792	908	N>S		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA390015493 rs1566762795	910	A>T		No	ClinGen Ensembl
CA7230789 rs776584817	911	A>T		No	ClinGen ExAC gnomAD
CA7230788 rs764059771	912	N>K		No	ClinGen ExAC gnomAD
CA390015480 rs1594780839	912	N>S		No	ClinGen Ensembl
CA7230787 rs142637501	913	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs775663450 CA7230786	913	S>R		No	ClinGen ExAC gnomAD
CA390015464 rs1282438063	914	L>F		No	ClinGen TOPMed
rs1409755521 CA390015468	914	L>W		No	ClinGen gnomAD
CA390015448 rs1376089312	917	S>G		No	ClinGen gnomAD
CA262646103 rs951323347	919	H>R		No	ClinGen TOPMed
rs772095325 CA7230785	919	H>Y		No	ClinGen ExAC TOPMed
CA390015428 rs1401823259	920	P>A		No	ClinGen gnomAD
rs944154148 CA262646099	920	P>L		No	ClinGen Ensembl
rs1401823259 CA390015429	920	P>T		No	ClinGen gnomAD
rs564951922 CA7230783	921	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs147984790 CA7230782	921	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs564951922 CA7230784	921	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199859148 CA7230781	922	S>G		No	ClinGen ExAC gnomAD
rs1181287253 CA390015418	922	S>T		No	ClinGen gnomAD
CA390015396 rs1475506896	925	V>E		No	ClinGen gnomAD
CA390015394 rs1475506896	925	V>G		No	ClinGen gnomAD
CA390015376 rs1207462803	928	Y>H		No	ClinGen gnomAD
rs1404767677 CA390015363	929	Q>H		No	ClinGen gnomAD
CA262646061 COSM1290311 rs976167557	930	D>G	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs770234768 CA7230779	930	D>N		No	ClinGen ExAC gnomAD
rs1189194929 CA390015355	931	H>Y		No	ClinGen TOPMed
CA390015331 rs1331593364	934	T>N		No	ClinGen TOPMed gnomAD
rs1331593364 CA390015330	934	T>S		No	ClinGen TOPMed gnomAD
rs199733111 CA7230757	936	W>C		No	ClinGen ExAC TOPMed gnomAD
rs776193793 CA262704478	938	A>S		No	ClinGen Ensembl
CA7230756 rs745310809	938	A>V		No	ClinGen ExAC TOPMed gnomAD
rs867901225 CA262704453	941	T>N		No	ClinGen gnomAD
rs1404681447 CA390047810	943	V>L		No	ClinGen gnomAD
rs1404681447 CA390047811	943	V>M		No	ClinGen gnomAD
rs778518876 COSM957069 CA7230755	944	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA390047797 rs1293991279	945	E>A		No	ClinGen TOPMed
CA7230752 rs374252512	946	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753596088 CA7230753	946	R>W		No	ClinGen ExAC gnomAD
CA7230750 rs752667759	947	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7230751 rs756040841	947	R>W		No	ClinGen ExAC TOPMed gnomAD
CA262704420 rs865914584	948	E>G		No	ClinGen gnomAD
CA390047786 rs1248808289	948	E>K		No	ClinGen gnomAD
CA390047775 rs1273842355	949	A>G		No	ClinGen gnomAD
rs767289762 CA7230749	951	D>E		No	ClinGen ExAC TOPMed gnomAD
CA262704415 rs200830894	951	D>G		No	ClinGen gnomAD
CA262704403 RCV001812415 rs983201841	953	A>G		No	ClinGen ClinVar TOPMed dbSNP
CA262704376 rs935007562	954	L>F		No	ClinGen Ensembl
CA7230747 rs370398211 COSM1227463	955	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA390047733 rs1566759394	957	H>Y		No	ClinGen Ensembl
CA262704374 rs922976456	958	N>D		No	ClinGen TOPMed gnomAD
rs1354994260 CA390047719	959	Y>N		No	ClinGen gnomAD
rs200877686 CA7230746	960	C>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA390047710 rs1309335219	960	C>Y		No	ClinGen gnomAD
rs149316006 RCV001508726 CA7230744 RCV000733349	961	V>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7230745 rs149316006	961	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230743 rs367782249	963	C>Y		No	ClinGen ESP ExAC gnomAD
rs777063192 CA7230741	964	E>K		No	ClinGen ExAC TOPMed gnomAD
CA7230740 rs769006810	965	E>D		No	ClinGen ExAC gnomAD
rs1175750348 CA390047654	968	K>R		No	ClinGen TOPMed
rs138556050 CA7230739 COSM241752	971	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1408138151 CA390047615	973	K>N		No	ClinGen gnomAD
CA390047589 rs986293048	977	V>A		No	ClinGen TOPMed gnomAD
CA262704312 rs986293048	977	V>G		No	ClinGen TOPMed gnomAD
CA7230734 rs72724498	978	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs777627078 CA7230735	978	E>G		No	ClinGen ExAC gnomAD
CA7230736 rs748944269	978	E>K		No	ClinGen ExAC gnomAD
rs1314130251 CA390047583	979	S>T		No	ClinGen gnomAD
CA262704272 rs543732559	984	G>E		No	ClinGen 1000Genomes gnomAD
CA7230729 rs562590442	985	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
COSM1562577 CA7230730 rs371628390	985	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA7230728 rs758526994	986	D>Y		No	ClinGen ExAC gnomAD
CA390047532 rs1566759241	987	L>R		No	ClinGen Ensembl
CA7230727 rs541056104	989	G>C		No	ClinGen 1000Genomes ExAC gnomAD
CA7230726 rs550669563	989	G>V		No	ClinGen ExAC TOPMed gnomAD
CA390047512 rs1357023468	991	I>V		No	ClinGen gnomAD
rs776814615 CA7230724 COSM1370624	992	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs761057312 CA7230722	994	Q>R		No	ClinGen ExAC gnomAD
CA7230721 rs776134235	999	G>E		No	ClinGen ExAC TOPMed gnomAD
CA390047460 rs1251222122	999	G>R		No	ClinGen gnomAD
CA7230716 rs146911028	1002	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230717 rs146911028	1002	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230715 rs780815297	1002	R>H		No	ClinGen ExAC TOPMed gnomAD
rs146911028 CA7230718	1002	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1226542860 CA390047435	1003	D>V		No	ClinGen gnomAD
RCV001812280 CA7230712 rs779906104	1004	V>M		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs151112486 CA390047421	1006	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs151112486 CA7230710	1006	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs370871216 CA7230709	1009	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs377620114 CA7230706	1010	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230705 RCV001810654 rs556377923	1010	R>H		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs377620114 CA7230707	1010	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230704 rs776012646	1012	D>N		No	ClinGen ExAC gnomAD
rs760141425 CA7230702	1014	L>P		No	ClinGen ExAC gnomAD
COSM303294 rs573498417 CA7230701	1016	R>C	Variant assessed as Somatic; 0.0 impact. central_nervous_system stomach [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM2248634 rs769384891 CA7230700	1016	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs761363915 CA7230699	1017	E>K		No	ClinGen ExAC TOPMed gnomAD
CA390047358 rs761363915	1017	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1341052202 CA390047337	1020	Q>K		No	ClinGen Ensembl
CA390047334 rs1206538272	1020	Q>P		No	ClinGen gnomAD
CA7230697 rs768203873	1022	M>I		No	ClinGen ExAC gnomAD
CA7230698 rs776399099	1022	M>T		No	ClinGen ExAC gnomAD
rs142823994 CA390047311	1023	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230694 rs190108600	1024	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230695 rs190108600	1024	S>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390047303 rs1396905761	1025	H>Y		No	ClinGen gnomAD
CA7230692 rs778936613	1026	P>A		No	ClinGen ExAC gnomAD
CA390047281 rs1366865059	1028	Q>R		No	ClinGen gnomAD
rs1232166362 CA390047273	1029	K>T		No	ClinGen TOPMed
rs757425728 CA7230691	1030	E>K		No	ClinGen ExAC gnomAD
rs1047765 CA262704046	1031	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1164403722 CA390047246	1033	G>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA390047248 rs1164403722	1033	G>S		No	ClinGen TOPMed gnomAD
CA390047239 rs1213126107	1034	Q>R		No	ClinGen TOPMed
rs148507591 CA7230687	1035	R>Q		No	ClinGen ESP ExAC gnomAD
rs1164127919 CA390047227	1036	Q>R		No	ClinGen gnomAD
CA7230685 rs760088579	1038	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs986795772 CA262704000	1039	L>V		No	ClinGen TOPMed gnomAD
CA390047202 rs1211615857	1040	E>K		No	ClinGen gnomAD
rs1485350366 CA390047191	1041	E>A		No	ClinGen TOPMed
rs764635536 CA7230683	1042	L>P		No	ClinGen ExAC gnomAD
RCV001002152 rs1594775390 RCV003141926 CA390047180	1043	W>*		No	ClinGen ClinVar Ensembl dbSNP
CA7230682 rs146819160	1043	W>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1228426231 CA390047164	1045	G>S		No	ClinGen gnomAD
rs1424196999 CA390047161	1045	G>V		No	ClinGen TOPMed
CA390047145 rs1343868033	1048	Q>*		No	ClinGen gnomAD
rs199994404 CA262703975	1048	Q>H		No	ClinGen 1000Genomes
CA390047129 rs1227199684	1051	Q>K		No	ClinGen gnomAD
CA7230679 rs143644014	1052	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230680 rs768317667	1052	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1389071244 CA390047101	1055	D>N		No	ClinGen gnomAD
CA390047088 rs1594775353	1056	L>F		No	ClinGen Ensembl
COSM1707461 CA390047081 rs1389145740	1058	G>R	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
CA262703953 rs763939872	1058	G>V		No	ClinGen Ensembl
rs962149048 CA262703950	1059	E>A		No	ClinGen Ensembl
rs775248207 CA7230678	1059	E>D		No	ClinGen ExAC TOPMed gnomAD
rs771898660 CA7230677	1060	V>I		No	ClinGen ExAC gnomAD
CA390047046 rs1372481726	1063	L>P		No	ClinGen gnomAD
rs375116881 CA390047037	1064	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA262703918 rs905862271	1066	F>S		No	ClinGen TOPMed
CA7230674 rs770789297	1068	Q>K		No	ClinGen ExAC gnomAD
CA7230673 rs371774042	1068	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs777736294 CA7230672	1072	D>V		No	ClinGen ExAC gnomAD
CA262703885 rs1006492983	1073	F>I		No	ClinGen TOPMed
CA390046979 rs1269972919	1073	F>L		No	ClinGen TOPMed
rs1205252633 CA390046976	1074	Q>E		No	ClinGen gnomAD
CA390046977 rs1205252633	1074	Q>K		No	ClinGen gnomAD
CA390046965 rs1346219302	1075	A>G		No	ClinGen TOPMed
CA7230670 rs45507992	1076	W>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230671 rs756334913	1076	W>G		No	ClinGen ExAC TOPMed gnomAD
rs1347462204 CA390046954	1077	L>F		No	ClinGen TOPMed
CA7230669 rs200926839	1078	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230668 rs755447675	1080	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1287097479 CA390046930	1081	Q>R		No	ClinGen Ensembl
rs374585997 CA7230667	1083	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390046908 rs1301265044	1084	V>A		No	ClinGen TOPMed gnomAD
rs766839603 CA7230666	1085	A>V		No	ClinGen ExAC TOPMed gnomAD
CA390046885 rs1429381408	1088	D>Y		No	ClinGen gnomAD
CA7230664 rs753342542	1089	M>V		No	ClinGen ExAC TOPMed gnomAD
CA7230662 rs760294011	1091	E>K		No	ClinGen ExAC TOPMed gnomAD
CA390046857 rs1318178118	1092	S>P		No	ClinGen TOPMed
rs1376847984 CA390046850	1093	L>F		No	ClinGen gnomAD
CA262703771 rs201653621	1095	E>K		No	ClinGen 1000Genomes TOPMed gnomAD
CA262703763 rs1023515670	1096	A>T		No	ClinGen TOPMed
CA390046815 rs1180768765	1098	Q>H		No	ClinGen gnomAD
CA7230661 rs138439282	1098	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA390046813 rs1370491661	1099	L>F		No	ClinGen TOPMed
COSM1370622 rs1241237774 CA390046790	1102	Q>R	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA390046780 rs1198368141	1103	H>Q		No	ClinGen TOPMed gnomAD
rs759269770 CA7230659	1103	H>R		No	ClinGen ExAC TOPMed gnomAD
CA390046775 rs374648585	1104	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs893624840 CA262703702	1106	I>M		No	ClinGen TOPMed gnomAD
rs770863430 CA7230657	1106	I>V		No	ClinGen ExAC
CA390046748 rs1229590428	1108	D>E		No	ClinGen gnomAD
rs139214218 CA7230656	1111	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA390046723 rs748367584	1112	G>A		No	ClinGen ExAC TOPMed gnomAD
CA7230653 rs748367584	1112	G>E		No	ClinGen ExAC TOPMed gnomAD
CA7230654 rs150796721	1112	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230652 rs781503502	1113	H>R		No	ClinGen ExAC gnomAD
CA390046714 rs1594775034	1114	Q>E		No	ClinGen Ensembl
rs1394493410 CA390046686	1117	Y>C		No	ClinGen gnomAD
rs747335265 CA7230650	1119	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7230649 rs553593159	1119	R>H		No	ClinGen ExAC TOPMed gnomAD
CA390046674 rs747335265	1119	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1395588185 CA390046670	1120	V>I		No	ClinGen gnomAD
CA7230648 rs775202372	1123	S>P		No	ClinGen ExAC TOPMed gnomAD
CA390046622 rs1157779083	1126	K>N		No	ClinGen gnomAD
rs767091844 CA7230643	1128	I>M		No	ClinGen ExAC TOPMed gnomAD
CA7230644 rs752216665	1128	I>T		No	ClinGen ExAC gnomAD
CA7230645 rs755679221	1128	I>V		No	ClinGen ExAC gnomAD
CA7230642 rs769684663	1129	Q>R		No	ClinGen ExAC TOPMed gnomAD
RCV001812371 rs2082573854	1131	Q>*		No	ClinVar dbSNP
rs1394283404 CA390046593	1131	Q>R		No	ClinGen TOPMed
CA7230640 rs186859277	1132	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773081060 CA7230638	1133	D>G		No	ClinGen ExAC gnomAD
CA7230636 rs748167525	1135	E>D		No	ClinGen ExAC TOPMed gnomAD
rs375618460 CA7230637	1135	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
RCV001002421 CA7230635 rs776879148	1137	L>M		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1320997133 CA390046548	1139	L>M		No	ClinGen gnomAD
rs141173028 CA390046526	1142	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390046528 rs1436929613	1142	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7230632 rs199840127	1144	E>G		No	ClinGen ExAC gnomAD
CA7230633 rs747247179	1144	E>Q		No	ClinGen ExAC gnomAD
rs571964071 CA7230631	1145	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs199709844 CA262703507	1146	L>M		No	ClinGen 1000Genomes TOPMed gnomAD
rs1390340680 CA390046503	1147	D>Y		No	ClinGen gnomAD
rs77806 CA262703478	1151	N>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230626 rs767038559	1151	N>K		No	ClinGen ExAC gnomAD
rs752165358 CA7230627	1151	N>S		No	ClinGen ExAC gnomAD
CA262703448 rs980602524	1152	A>G		No	ClinGen TOPMed gnomAD
rs754591398 CA7230625	1152	A>T		No	ClinGen ExAC
CA7230624 COSM698953 rs751235570	1154	G>D	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA390046463 rs1435734860	1154	G>S		No	ClinGen TOPMed
rs751235570 CA390046459	1154	G>V		No	ClinGen ExAC TOPMed gnomAD
CA262703431 rs1016291916	1155	R>G		No	ClinGen TOPMed
rs79725829 CA7230623	1157	W>G		No	ClinGen ExAC
CA7230622 rs762597840	1158	E>Q		No	ClinGen ExAC gnomAD
CA262703419 rs771810616	1159	S>G		No	ClinGen Ensembl
CA390046425 rs1359006770	1159	S>T		No	ClinGen gnomAD
rs765222922 CA7230620	1160	R>C		No	ClinGen ExAC TOPMed gnomAD
rs76283214 CA7230619	1160	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230617 rs768901063	1161	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1300290638 CA390046418	1161	S>R		No	ClinGen TOPMed
CA390046412 rs1437142594	1161	S>R		No	ClinGen gnomAD
CA7230615 rs377560569	1163	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs377560569 CA390046399	1163	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1490726834 CA390046392	1165	A>T		No	ClinGen gnomAD
CA7230612 rs779282753	1166	Q>R		No	ClinGen ExAC gnomAD
rs145875201 CA262703353	1168	L>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs1388745080 CA390046369	1168	L>P		No	ClinGen gnomAD
CA7230611 rs749833541	1171	Q>P		No	ClinGen ExAC gnomAD
CA7230610 rs749833541	1171	Q>R		No	ClinGen ExAC gnomAD
rs1231541608 CA390046342	1172	E>G		No	ClinGen TOPMed
rs754503810 CA7230608	1175	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1291286548 CA390046318	1175	K>R		No	ClinGen TOPMed
rs1490223841 CA390046303	1177	A>G		No	ClinGen gnomAD
rs1275420408 CA390046297	1178	K>R		No	ClinGen gnomAD
CA7230607 rs143493156	1180	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs3210340 CA262703326	1180	A>V		No	ClinGen Ensembl
rs1007738752 CA262703320	1183	I>V		No	ClinGen TOPMed
CA390046251 rs1227189633	1185	S>I		No	ClinGen TOPMed gnomAD
CA390046253 rs1227189633	1185	S>N		No	ClinGen TOPMed gnomAD
CA390046256 rs1194934142	1185	S>R		No	ClinGen TOPMed
rs1469756813 CA390046220	1188	E>K		No	ClinGen gnomAD
rs201441326 CA7230583	1190	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756109744 CA7230582	1190	T>S		No	ClinGen ExAC
rs767687371 CA7230580	1191	L>R		No	ClinGen ExAC TOPMed gnomAD
rs752671489 CA262703083	1191	L>V		No	ClinGen ExAC TOPMed gnomAD
rs759671854 CA7230579	1192	A>P		No	ClinGen ExAC gnomAD
rs766601064 CA7230577	1194	L>W		No	ClinGen ExAC gnomAD
rs367840098 CA7230575	1195	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1566757728 CA390046167	1196	P>R		No	ClinGen Ensembl
rs1229710369 CA390046153	1198	D>E		No	ClinGen gnomAD
rs774828453 CA7230572	1198	D>N		No	ClinGen ExAC TOPMed gnomAD
CA390046122 rs1389836671	1203	A>E		No	ClinGen TOPMed gnomAD
rs1452286295 CA390046126	1203	A>T		No	ClinGen gnomAD
CA390046109 rs1323207561	1205	A>D		No	ClinGen gnomAD
rs1452230204 CA390046107	1206	G>R		No	ClinGen gnomAD
rs1363336216 CA390046100	1207	I>V		No	ClinGen gnomAD
CA7230566 rs139262198	1208	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
COSM433254 rs374240422 CA7230567	1208	R>W	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA7230563 rs752722915	1209	K>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs754992620 CA7230561	1212	D>G		No	ClinGen ExAC gnomAD
CA390046061 rs1265540580	1213	F>I		No	ClinGen gnomAD
rs766548051 CA7230559	1215	G>A		No	ClinGen ExAC gnomAD
CA390046041 rs1348896251	1216	S>A		No	ClinGen TOPMed
CA390046040 rs1348896251	1216	S>P		No	ClinGen TOPMed
CA7230558 rs146846892	1217	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368552247 CA7230557	1219	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA7230556 rs368552247	1219	N>T		No	ClinGen ESP ExAC gnomAD
rs1300227594 CA390046011	1220	N>H		No	ClinGen gnomAD
CA7230555 rs201849832	1221	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA390046004 rs1381051370	1221	R>W		No	ClinGen gnomAD
rs777255682 CA390046000	1222	D>N		No	ClinGen ExAC TOPMed gnomAD
COSM1732556 rs777255682 CA7230554	1222	D>Y	NS [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA262702957 rs1006582019	1228	V>L		No	ClinGen gnomAD
rs1450292241 CA390045951	1229	D>G		No	ClinGen gnomAD
CA7230551 rs774029248	1230	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1267889389 CA390045915	1235	V>I		No	ClinGen gnomAD
CA390045903 rs1192844436	1237	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM1707459 rs1184589084 CA390045890	1238	G>E	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
CA390045881 rs1445784766	1240	L>I		No	ClinGen Ensembl
CA390045875 rs1205472431	1241	Y>H		No	ClinGen gnomAD
CA7230548 rs777400404	1243	D>E		No	ClinGen ExAC gnomAD
rs976130875 CA262702932	1247	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA390045816 rs1373154036	1249	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1343483831 CA390045807	1250	Q>R		No	ClinGen gnomAD
COSM1227456 rs1302660993 CA390045794	1252	I>T	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA7230545 rs781116290	1253	E>G		No	ClinGen ExAC gnomAD
rs868131072 CA262702917	1253	E>K		No	ClinGen Ensembl
CA390045785 rs1347493519	1254	D>N		No	ClinGen TOPMed
rs965294354 CA262702800	1259	N>K		No	ClinGen Ensembl
CA390045724 rs1450102801	1260	N>S		No	ClinGen gnomAD
CA7230508 rs776378723	1260	N>Y		No	ClinGen ExAC TOPMed gnomAD
CA7230505 rs775350990	1261	E>G		No	ClinGen ExAC gnomAD
CA7230506 rs746933929	1261	E>K		No	ClinGen ExAC TOPMed gnomAD
CA390045704 rs1405209052	1263	A>G		No	ClinGen gnomAD
rs904850369 CA262702786	1263	A>S		No	ClinGen TOPMed
CA262702783 rs912491095	1266	A>T		No	ClinGen Ensembl
CA7230501 rs757483034	1267	S>C		No	ClinGen ExAC gnomAD
CA262702754 rs765221153	1268	V>I		No	ClinGen Ensembl
rs765221153 CA262702758	1268	V>L		No	ClinGen Ensembl
rs201313127 CA7230498	1269	L>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7230500 rs778280369	1269	L>V		No	ClinGen ExAC gnomAD
rs1267445474 CA390045652	1272	D>A		No	ClinGen TOPMed
rs370662950 CA7230495	1274	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs370662950 CA7230496	1274	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1282268795 CA390045629	1276	L>V		No	ClinGen gnomAD
CA390045619 rs1204568319	1277	Q>H		No	ClinGen gnomAD
rs764693974 CA7230493	1278	N>S		No	ClinGen ExAC TOPMed gnomAD
CA7230492 rs376325010	1279	F>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs369252262 CA7230489	1283	C>F		No	ClinGen ExAC gnomAD
rs771997733 CA390045568	1284	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA390045574 rs1343304057	1284	Q>K		No	ClinGen gnomAD
rs775296073 CA7230488	1284	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA7230486 rs745845637	1285	E>A		No	ClinGen ExAC gnomAD
rs1271170656 CA390045546	1286	L>F		No	ClinGen gnomAD
CA390045542 rs1197292878	1287	T>A		No	ClinGen gnomAD
CA390045537 rs1490250188	1287	T>I		No	ClinGen gnomAD
CA390045541 rs1197292878	1287	T>S		No	ClinGen gnomAD
CA7230469 rs774216236	1291	N>K		No	ClinGen ExAC TOPMed gnomAD
rs770916821 CA7230467	1292	D>N		No	ClinGen ExAC gnomAD
CA7230466 rs763084936	1293	K>E		No	ClinGen ExAC gnomAD
rs145433957 CA390045494	1293	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770115757 CA7230464	1294	L>M		No	ClinGen ExAC gnomAD
CA7230461 rs368833188	1297	S>F		No	ClinGen ESP ExAC TOPMed
rs1350562659 CA614440949	1297	S>I		No	ClinGen gnomAD
rs368833188 CA390045475	1297	S>Y		No	ClinGen ESP ExAC TOPMed
rs747412251 CA7230460	1300	V>A		No	ClinGen ExAC gnomAD
CA262702041 rs948225516	1301	S>C		No	ClinGen TOPMed
CA7230459 rs780357227	1302	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA262702032 rs753297883	1303	D>H		No	ClinGen ExAC gnomAD
rs753297883 CA7230457	1303	D>Y		No	ClinGen ExAC gnomAD
CA7230454 rs752416927	1306	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA262702004 rs1038287944 CA390045411	1307	N>K		No	ClinGen TOPMed gnomAD
rs1174904742 CA390045406	1308	L>P		No	ClinGen gnomAD
rs767333869 CA7230453	1309	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA7230452 rs759195991	1310	N>K		No	ClinGen ExAC gnomAD
CA390045394 rs1594772211	1310	N>S		No	ClinGen Ensembl
rs140446828 CA7230451	1312	W>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1479756011 CA390045368	1314	K>E		No	ClinGen gnomAD
rs766175855 CA7230449	1315	H>Q		No	ClinGen ExAC gnomAD
CA390045359 rs1594772189	1315	H>Y		No	ClinGen Ensembl
rs763029819 CA7230448	1317	A>P		No	ClinGen ExAC gnomAD
CA7230447 COSM1370618 rs768710888	1317	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1594772168 CA390045328	1320	A>T		No	ClinGen Ensembl
rs762112620 CA7230445	1320	A>V		No	ClinGen ExAC gnomAD
CA390045312 rs1308471547	1322	L>R		No	ClinGen gnomAD
CA262701953 rs541889464	1322	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1221739657 CA390045310	1323	A>P		No	ClinGen gnomAD
CA390045296 rs146778255	1325	H>P		No	ClinGen ESP TOPMed gnomAD
rs146778255 CA262701952	1325	H>R		No	ClinGen ESP TOPMed gnomAD
CA390045286 rs1279342786	1326	E>D		No	ClinGen gnomAD
rs1453923191 CA390045284	1327	G>R		No	ClinGen gnomAD
rs1408744606 CA390045279	1327	G>V		No	ClinGen gnomAD
rs1469708148 CA390045270	1328	W>C		No	ClinGen gnomAD
rs1594772110 CA390045276	1328	W>G		No	ClinGen Ensembl
rs1299379767 CA390045260	1330	E>G		No	ClinGen TOPMed
rs1339398663 CA390045255	1331	N>H		No	ClinGen TOPMed
CA7230440 rs746414660	1333	D>H		No	ClinGen ExAC TOPMed gnomAD
rs746414660 CA7230439	1333	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
RCV000756712 rs113139501 CA7230438	1334	A>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs758666794 CA262700925	1335	E>K		No	ClinGen Ensembl
rs865845274 CA262700922	1336	G>R		No	ClinGen Ensembl
rs1224287786 CA390045204	1337	K>R		No	ClinGen gnomAD
CA390045194 rs1356759800	1338	Q>L		No	ClinGen gnomAD
CA7230417 rs746365542	1339	L>R		No	ClinGen ExAC gnomAD
rs1290056339 CA390045190	1339	L>V		No	ClinGen gnomAD
rs908533278 CA262700906	1347	T>I		No	ClinGen TOPMed gnomAD
CA7230413 rs369444753	1349	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1163171250 CA390045105	1352	Q>K		No	ClinGen gnomAD
rs1594770057 RCV001000999	1353	K>missing		No	ClinVar dbSNP
rs146570433 CA262700889	1358	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs905908428 CA262700891	1358	H>R		No	ClinGen Ensembl
CA390045046 rs1405421214	1361	W>S		No	ClinGen TOPMed
CA7230408 rs765225112	1362	D>E		No	ClinGen ExAC TOPMed gnomAD
COSM273299 CA7230406 rs776511812	1363	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1196004546 CA390045020	1365	Q>*		No	ClinGen gnomAD
rs753842456 CA262700865	1366	A>P		No	ClinGen ExAC TOPMed gnomAD
rs753842456 CA7230405	1366	A>T		No	ClinGen ExAC TOPMed gnomAD
CA390045009 rs1253412586	1367	T>A		No	ClinGen gnomAD
CA7230402 rs775843992	1371	K>R		No	ClinGen ExAC gnomAD
rs142640389 CA7230400	1373	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA390044961 rs1221558226	1374	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs200559187 CA7230398	1376	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1052947217 CA262700839	1377	A>T		No	ClinGen Ensembl
CA390044923 rs775995989	1380	S>I		No	ClinGen ExAC gnomAD
CA7230396 rs775995989	1380	S>N		No	ClinGen ExAC gnomAD
CA390044910 rs371649655	1382	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230393 rs569713799	1382	D>G		No	ClinGen 1000Genomes ExAC gnomAD
rs746513424 CA7230394	1382	D>N		No	ClinGen ExAC TOPMed gnomAD
rs367610564 CA7230391	1383	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1194374612 CA390044906	1383	L>P		No	ClinGen gnomAD
rs778901641 CA7230390	1384	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7230389 rs757113392	1384	R>H		No	ClinGen ExAC gnomAD
rs894413251 CA262700814	1387	T>S		No	ClinGen TOPMed
rs1405959110 CA390044876	1388	H>R		No	ClinGen gnomAD
CA262700796 rs1055690350	1390	D>H		No	ClinGen TOPMed
rs886050619 CA390044847	1392	N>K		No	ClinGen TOPMed
CA7230387 rs764068701	1392	N>S		No	ClinGen ExAC gnomAD
rs144621253 CA7230386 CA390044831	1394	W>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1337694456 CA390044820	1396	S>N		No	ClinGen gnomAD
rs759799491 CA7230384	1397	A>S		No	ClinGen ExAC TOPMed gnomAD
rs759799491 CA7230383	1397	A>T		No	ClinGen ExAC TOPMed gnomAD
rs17180350 CA7230381	1403	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs545984220 CA7230382	1403	R>W		No	ClinGen ExAC TOPMed gnomAD
CA262700760 rs950346432	1404	S>L		No	ClinGen Ensembl
CA7230378 rs770206796	1406	D>N		No	ClinGen ExAC TOPMed gnomAD
rs147131185 CA7230377	1407	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390044749 rs1159711774	1407	P>S		No	ClinGen TOPMed gnomAD
rs1159711774 CA390044751	1407	P>T		No	ClinGen TOPMed gnomAD
rs17245552 CA7230375	1408	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390044745 rs1594769822	1408	G>D		No	ClinGen Ensembl
CA7230373 rs778846532	1410	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1460335603 CA390044701	1415	N>H		No	ClinGen TOPMed gnomAD
CA262700712 rs921527857	1415	N>S		No	ClinGen TOPMed gnomAD
rs1460335603 CA390044702	1415	N>Y		No	ClinGen TOPMed gnomAD
CA7230370 rs777704033	1416	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs975597244 CA262700706	1416	R>W		No	ClinGen TOPMed gnomAD
rs756040224 CA7230369	1417	M>K		No	ClinGen ExAC gnomAD
CA262700694 rs1021660417	1418	L>F		No	ClinGen Ensembl
rs1271230465 CA390044673	1419	A>V		No	ClinGen gnomAD
rs150323295 CA7230351	1423	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs781231618 RCV001812506 CA7230350	1425	E>K		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs780282298 CA7230347	1426	D>E		No	ClinGen ExAC TOPMed gnomAD
rs754988940 CA7230349	1426	D>V		No	ClinGen ExAC gnomAD
rs750776585 CA7230345	1428	V>G		No	ClinGen ExAC gnomAD
CA390044607 rs567454803	1428	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7230346 rs567454803	1428	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA390044594 rs1240452276	1430	V>M		No	ClinGen gnomAD
CA7230343 rs757836263 COSM957062	1431	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA262699348 COSM698955 rs943876155	1431	R>Q	lung Variant assessed as Somatic; 0.0 impact. skin [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs759052809 CA7230340	1433	E>D		No	ClinGen ExAC gnomAD
rs764712285 CA7230341	1433	E>G		No	ClinGen ExAC gnomAD
CA7230339 rs773768310	1434	E>Q		No	ClinGen ExAC gnomAD
rs1277028532 CA390044565	1435	L>V		No	ClinGen TOPMed gnomAD
CA390044557 rs1300958852	1436	G>E		No	ClinGen gnomAD
rs1346828165 CA390044561	1436	G>R		No	ClinGen gnomAD
CA262699277 rs953675033	1440	A>S		No	ClinGen TOPMed
CA7230336 rs773051278	1441	Q>E		No	ClinGen ExAC gnomAD
rs769530469 CA7230335	1442	V>M		No	ClinGen ExAC gnomAD
rs747947771 CA7230334	1445	M>V		No	ClinGen ExAC TOPMed gnomAD
CA390044457 rs1431504811	1451	D>E		No	ClinGen gnomAD
rs997243304 CA262699245	1452	A>T		No	ClinGen TOPMed
rs768609633 CA7230331	1452	A>V		No	ClinGen ExAC gnomAD
rs1487199875 CA390044437	1455	S>G		No	ClinGen TOPMed
rs371440362 CA262699239	1457	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs371440362 CA262699224	1457	E>Q		No	ClinGen ESP TOPMed gnomAD
CA390044410 rs1233259263	1458	K>N		No	ClinGen gnomAD
COSM1235254 rs148127231 CA7230328	1459	R>Q	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA gnomAD
rs780155773 CA7230329	1459	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs757639847 CA7230325	1462	D>G		No	ClinGen ExAC TOPMed gnomAD
rs779323039 CA390044392	1462	D>N		No	ClinGen ExAC gnomAD
rs779323039 CA7230326	1462	D>Y		No	ClinGen ExAC gnomAD
rs754260970 CA7230324	1465	E>D		No	ClinGen ExAC gnomAD
rs1160994776 CA390044371	1465	E>G		No	ClinGen TOPMed
rs1280762398 CA390044375	1465	E>K		No	ClinGen gnomAD
CA390044364 rs1358996802	1466	P>R		No	ClinGen TOPMed
rs756714150 CA7230322	1470	R>G		No	ClinGen ExAC gnomAD
rs570908790 CA7230321	1471	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA390044278 rs1408422452	1479	A>V		No	ClinGen TOPMed gnomAD
CA7230320 rs765869279	1480	K>R		No	ClinGen ExAC gnomAD
rs1409357450 CA390044255	1483	I>F		No	ClinGen Ensembl
rs1377781579 CA390044245	1484	S>N		No	ClinGen TOPMed
rs143829550 CA7230317	1484	S>R		No	ClinGen ESP ExAC gnomAD
CA7230314 rs140697785	1485	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230313 rs140697785	1485	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
RCV001001225 CA7230315 rs373557486	1485	R>W		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1184164788 CA390044197	1491	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7230294 rs763942503	1492	L>V		No	ClinGen ExAC gnomAD
rs1295859631 CA390044177	1493	W>G		No	ClinGen gnomAD
rs1295859631 CA390044179	1493	W>R		No	ClinGen gnomAD
rs1594766743 CA390044165	1494	V>G		No	ClinGen Ensembl
rs772053165 CA7230291	1495	E>K		No	ClinGen ExAC gnomAD
rs1594766703 CA390044144	1497	R>S		No	ClinGen Ensembl
rs1303977341 CA390044121	1501	A>V		No	ClinGen gnomAD
rs141214410 CA262698807	1504	A>T		No	ClinGen ESP TOPMed gnomAD
rs1421043694 CA390044098	1505	D>G		No	ClinGen gnomAD
COSM3401410 rs1429001823 CA390044102	1505	D>N	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1190796752 CA390044090	1506	Y>C		No	ClinGen TOPMed gnomAD
CA7230285 rs375743316	1509	N>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA262698759 rs979945351	1510	L>P		No	ClinGen Ensembl
rs1251163772 CA390044063	1511	Q>K		No	ClinGen TOPMed
CA7230284 rs748548058	1512	T>A		No	ClinGen ExAC gnomAD
rs1468130075 CA390044049	1513	V>L		No	ClinGen TOPMed
CA7230282 rs755530704	1515	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1297820684 CA390044031	1516	F>L		No	ClinGen gnomAD
rs756897454 CA7230279	1517	M>I		No	ClinGen ExAC TOPMed gnomAD
CA7230280 rs146588994	1517	M>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs146588994 CA7230281	1517	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs200187680 CA7230278	1519	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA262698720 rs890997122	1520	N>T		No	ClinGen TOPMed gnomAD
CA390043970 rs1240372784	1522	T>I		No	ClinGen gnomAD
CA7230248 rs765352994	1524	Q>K		No	ClinGen ExAC gnomAD
rs1457666793 CA390043955	1525	N>D		No	ClinGen gnomAD
CA7230247 rs373724473	1525	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1457666793 CA390043954	1525	N>Y		No	ClinGen gnomAD
rs1411392408 CA390043930	1528	L>P		No	ClinGen Ensembl
rs747387364 CA7230244	1529	G>C		No	ClinGen ExAC TOPMed gnomAD
CA390043928 rs747387364	1529	G>S		No	ClinGen ExAC TOPMed gnomAD
rs775909340 CA7230243	1530	H>R		No	ClinGen ExAC TOPMed gnomAD
rs149999354 CA390043913	1531	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs149999354 CA7230242	1531	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs149999354 CA390043912	1531	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230240 rs200639803	1532	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs868739957 CA262695926	1533	R>Q		No	ClinGen gnomAD
CA7230238 rs140301241	1533	R>W	Variant assessed as Somatic; 4.67e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA390043899 rs1400842547	1534	V>A		No	ClinGen gnomAD
CA7230237 rs780839859	1536	D>G		No	ClinGen ExAC gnomAD
CA7230234 rs766366799	1541	G>W		No	ClinGen ExAC gnomAD
rs1460983869 CA390043831	1545	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA262695859 rs753726387	1547	A>T		No	ClinGen gnomAD
rs758456079 CA7230233	1547	A>V		No	ClinGen ExAC gnomAD
rs377634587 COSM40652 CA7230231	1548	A>V	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA390043801 rs1336461504	1549	E>D		No	ClinGen TOPMed
CA390043800 rs776854894	1550	I>F		No	ClinGen ExAC TOPMed gnomAD
rs776854894 CA7230229	1550	I>V		No	ClinGen ExAC TOPMed gnomAD
COSM1266754 rs760176952 CA7230227	1551	D>N	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1239239273 CA390043787	1552	C>R		No	ClinGen gnomAD
rs1359866151 CA390043762	1555	L>F		No	ClinGen gnomAD
rs1307153504 CA390043761	1555	L>P		No	ClinGen TOPMed
CA7230226 RCV001507835 rs140648376	1557	E>G		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7230225 rs373885193	1558	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs746416668 CA7230224	1558	R>H		No	ClinGen ExAC TOPMed gnomAD
rs373885193 CA390043743	1558	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA390043731 rs1465230559	1560	G>E		No	ClinGen TOPMed
rs769407207 CA7230222	1561	H>P		No	ClinGen ExAC gnomAD
rs878914236 CA262695772	1561	H>Y		No	ClinGen gnomAD
CA7230221 rs147213872	1563	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390043707 rs1472065566	1564	S>N		No	ClinGen gnomAD
CA7230220 rs780852707	1565	S>T		No	ClinGen ExAC gnomAD
rs1427578525 CA390043683	1567	D>E		No	ClinGen TOPMed
rs138126360 RCV001000295 CA7230218 RCV002068749	1567	D>H		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7230219 rs138126360	1567	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230216 rs139446085	1570	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230217 rs780033343	1570	R>W		No	ClinGen ExAC TOPMed gnomAD
CA262695735 rs927272478	1571	E>V		No	ClinGen TOPMed
rs750432544 CA7230215	1573	A>V		No	ClinGen ExAC gnomAD
rs1437656100 CA390043649	1574	A>T		No	ClinGen TOPMed
rs368865153 CA7230212	1575	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390043638 rs1594762236	1576	R>G		No	ClinGen Ensembl
CA390043625 rs1337741915	1578	Q>E		No	ClinGen gnomAD
rs927773729 CA262695697	1578	Q>R		No	ClinGen Ensembl
RCV001508365 rs760938057	1579	R>*		No	ClinVar dbSNP
CA7230209 rs376789095	1579	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA390043614 rs1350852044	1580	L>V		No	ClinGen TOPMed gnomAD
rs372204766 CA7230206	1583	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230205 rs372204766	1583	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1329787884 CA390043587	1584	N>S		No	ClinGen TOPMed
rs776051162 CA7230203	1585	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA390043576 rs1421537038	1586	A>T		No	ClinGen TOPMed gnomAD
RCV001813125 rs746722532	1589	Y>*		No	ClinVar dbSNP
CA7230199 rs549797168	1591	L>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7230198 rs536189861	1592	D>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA7230197 rs778870352	1593	A>E		No	ClinGen ExAC gnomAD
rs778870352 CA390043523	1593	A>V		No	ClinGen ExAC gnomAD
rs138279396 CA390043517 CA390043516	1594	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230195 rs753933934	1594	D>N		No	ClinGen ExAC gnomAD
CA7230193 rs756327499	1595	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1330864772 CA390043459	1602	E>D		No	ClinGen gnomAD
CA390043461 rs1434837735	1602	E>G		No	ClinGen gnomAD
COSM194074 CA390043466 rs1180402020	1602	E>K	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs4899145 CA7230189	1606	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs527302642 CA7230191	1606	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs527302642 CA7230190	1606	Y>S		No	ClinGen 1000Genomes ExAC gnomAD
rs763407007 CA7230187	1607	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1018561609 CA262695642	1608	I>L		No	ClinGen TOPMed
rs1169975625 CA390043422	1608	I>T		No	ClinGen gnomAD
rs1427595749 CA390043414	1610	D>N		No	ClinGen TOPMed gnomAD
CA7230183 rs775215288	1614	K>E		No	ClinGen ExAC gnomAD
CA390043336 rs537141390	1619	A>S		No	ClinGen ExAC TOPMed gnomAD
CA7230163 rs537141390	1619	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA390043335 rs1322921068	1619	A>V		No	ClinGen gnomAD
rs229592 CA390043326	1620	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390043331 rs1594761407	1620	I>V		No	ClinGen Ensembl
CA390043325 rs1229350121	1621	V>M		No	ClinGen TOPMed gnomAD
rs1361492153 CA390043300	1624	K>M		No	ClinGen gnomAD
CA7230160 rs749125417	1625	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA390043291 rs1392262841	1626	H>N		No	ClinGen Ensembl
CA390043276 COSM1370606 rs755882611	1628	R>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA7230159 rs755882611	1628	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA390043277 rs1457032754	1628	R>W		No	ClinGen gnomAD
RCV001810679 rs372503030 CA7230158	1631	R>C		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs201082918 CA7230157	1631	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs201082918 CA390043256	1631	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781286844 CA390043251	1632	A>E		No	ClinGen ExAC TOPMed gnomAD
rs1411013976 CA390043252	1632	A>S		No	ClinGen gnomAD
rs1411013976 CA390043254	1632	A>T		No	ClinGen gnomAD
rs781286844 CA7230156	1632	A>V		No	ClinGen ExAC TOPMed gnomAD
CA390043237 rs1594761292	1633	V>G		No	ClinGen Ensembl
rs1264943949 CA390043244	1633	V>M		No	ClinGen TOPMed gnomAD
CA7230154 rs747251107	1634	E>K		No	ClinGen ExAC TOPMed gnomAD
rs901736099 CA262691929	1635	D>G		No	ClinGen TOPMed
rs780335342 CA390043213	1635	D>N		No	ClinGen ExAC TOPMed gnomAD
rs780335342 CA7230153	1635	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1299401986 CA390043190	1636	Y>C		No	ClinGen TOPMed
CA390043197 rs1323954872	1636	Y>N		No	ClinGen TOPMed gnomAD
CA390043173 rs1227874792	1637	G>S		No	ClinGen gnomAD
rs368063704 CA7230151	1638	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765799075 CA7230150	1639	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1359689800 CA390043127	1641	K>E		No	ClinGen gnomAD
CA390043122 rs1293840327	1641	K>R		No	ClinGen gnomAD
rs1459384589 CA390043111	1642	Q>E		No	ClinGen gnomAD
rs867559352 CA262691904	1644	A>V		No	ClinGen Ensembl
rs1004837830 CA262691884	1645	S>N		No	ClinGen TOPMed
CA7230148 rs752231474	1646	R>Q		No	ClinGen ExAC gnomAD
CA7230149 rs111849078	1646	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1425099247 CA390043042	1647	A>S		No	ClinGen gnomAD
CA7230147 rs766992918	1649	G>D		No	ClinGen ExAC gnomAD
rs766992918 CA390043004	1649	G>V		No	ClinGen ExAC gnomAD
rs759219902 CA7230146	1652	S>C		No	ClinGen ExAC gnomAD
CA390042955 rs1261470871	1653	A>V		No	ClinGen gnomAD
CA390042917 rs1192200629	1656	P>S		No	ClinGen gnomAD
rs567367723 CA262691837	1658	G>E		No	ClinGen TOPMed gnomAD
CA262690545 rs1049329878	1661	I>V		No	ClinGen TOPMed
CA7230109 rs749681760	1664	L>F		No	ClinGen ExAC gnomAD
rs1023936846 CA262690510	1664	L>P		No	ClinGen Ensembl
rs778089194 CA7230108	1665	Q>K		No	ClinGen ExAC gnomAD
CA390042564 rs1256890835	1666	G>E		No	ClinGen gnomAD
RCV001091050 rs2082308925	1668	V>missing		No	ClinVar dbSNP
CA7230107 rs756672281	1668	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1477804445 CA390042539	1668	V>M		No	ClinGen TOPMed
CA7230106 rs751016084	1669	D>E		No	ClinGen ExAC gnomAD
CA7230105 rs201504825	1671	H>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs762226943 CA7230104	1672	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs756999416 CA7230101	1673	A>P		No	ClinGen ExAC gnomAD
CA7230102 rs756999416	1673	A>S		No	ClinGen ExAC gnomAD
rs756999416 CA390042457	1673	A>T		No	ClinGen ExAC gnomAD
rs773895447 CA7230100	1674	G>E		No	ClinGen ExAC TOPMed gnomAD
CA7230097 rs775419321	1675	L>V		No	ClinGen ExAC gnomAD
CA390042380 rs188341589	1678	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7230095 rs188341589	1678	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7230094 rs774655120 COSM2248549	1679	A>V	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs868011757 CA262690341	1680	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs111611921 CA7230090	1682	R>C		No	ClinGen ExAC TOPMed gnomAD
rs111611921 CA7230091	1682	R>G		No	ClinGen ExAC TOPMed gnomAD
rs748760619 CA7230089 COSM174055	1682	R>H	ovary large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs748760619 CA390042313	1682	R>L		No	ClinGen ExAC TOPMed gnomAD
rs781558180 CA7230088	1683	K>R		No	ClinGen ExAC gnomAD
RCV000733351 CA7230087 rs141226650	1684	R>C		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs148074782 CA7230085	1684	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230086 rs148074782	1684	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1489168804 CA390042287	1685	K>E		No	ClinGen gnomAD
CA390042256 rs1204496414	1687	E>G		No	ClinGen gnomAD
CA390042264 rs1200865169	1687	E>K		No	ClinGen TOPMed
rs375616137 CA7230082	1688	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7230079 rs767572838	1689	M>I		No	ClinGen ExAC gnomAD
rs752610763 CA7230080	1689	M>V		No	ClinGen ExAC gnomAD
CA7230077 rs774600016	1694	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1362857968 CA390042134	1695	L>F		No	ClinGen gnomAD
RCV001001746 CA7230074 rs199551302	1697	R>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs763298902 CA7230075	1697	R>W		No	ClinGen ExAC TOPMed gnomAD
CA390042074 rs1165481787	1699	T>N		No	ClinGen gnomAD
rs748477590 CA390042065	1700	D>H		No	ClinGen ExAC TOPMed gnomAD
COSM3719661 rs748477590 CA7230072	1700	D>N	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA7230069 rs369208136	1701	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7230070 rs369208136	1701	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1260772700 CA390042019	1703	E>*		No	ClinGen gnomAD
CA390042012 rs1192288927	1703	E>A		No	ClinGen gnomAD
rs778444104 CA7230068	1713	A>V		No	ClinGen ExAC gnomAD
rs376122148 CA262690122	1714	S>T		No	ClinGen ESP
CA262690117 rs991520284	1715	S>C		No	ClinGen TOPMed gnomAD
CA7230067 rs146532725	1716	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs777293570 CA7230065	1717	E>K		No	ClinGen ExAC gnomAD
COSM3744412 CA7230063 rs752454815 CA7230064	1721	D>E	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA390041732 rs1487638521	1721	D>Y		No	ClinGen TOPMed
CA7230060 rs145753633	1725	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1439284112 CA390041633	1726	T>I		No	ClinGen gnomAD
rs762481264 CA7230032	1727	L>F		No	ClinGen ExAC gnomAD
CA262689596 RCV001812432 rs753928257	1729	R>G		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA7230030 rs769460523	1729	R>L		No	ClinGen ExAC gnomAD
rs769460523 CA262689561	1729	R>Q		No	ClinGen ExAC gnomAD
CA7230031 rs753928257	1729	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1278963787 CA390041502	1730	D>E		No	ClinGen gnomAD
rs747858034 CA390041517	1730	D>N		No	ClinGen ExAC gnomAD
CA7230029 rs747858034	1730	D>Y		No	ClinGen ExAC gnomAD
CA390041460 rs1361177309	1733	R>Q		No	ClinGen TOPMed gnomAD
rs781000542 CA7230028	1733	R>W		No	ClinGen ExAC TOPMed gnomAD
CA390041418 rs1311263389	1736	A>T		No	ClinGen gnomAD
CA7230026 rs561976171	1737	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7230027 rs149727354	1737	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1216559614 CA390041409	1738	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs541815393 CA262689487	1740	G>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs1422841899 CA390041388	1741	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
COSM1370604 rs745940095 CA7230023	1741	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA262689418 rs929853070	1745	E>Q		No	ClinGen TOPMed
rs764312726 CA7230019	1746	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs200080131 CA7230020	1746	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA7230018 rs756419736	1749	N>D		No	ClinGen ExAC gnomAD
CA7230017 rs753089242	1749	N>S		No	ClinGen ExAC gnomAD
CA7230015 rs760005477	1751	N>S		No	ClinGen ExAC TOPMed gnomAD
CA262689368 rs772761835	1752	A>D		No	ClinGen ExAC TOPMed gnomAD
rs772761835 CA262689358	1752	A>V		No	ClinGen ExAC TOPMed gnomAD
rs764588479 CA7230013	1754	I>V		No	ClinGen ExAC gnomAD
rs374977591 CA262689334	1755	E>K		No	ClinGen ESP
RCV001813118 rs776376302 CA262689316	1756	R>L		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs776376302 CA7230011	1756	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7230010 rs768458105	1758	I>F		No	ClinGen ExAC gnomAD
CA390041287 rs1288432051	1758	I>T		No	ClinGen TOPMed
rs775200185 CA7230008	1759	D>N		No	ClinGen ExAC gnomAD
CA7230006 rs745859916	1760	A>T		No	ClinGen ExAC gnomAD
CA7230005 rs778913256	1760	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1264873239 CA390041272	1761	G>S		No	ClinGen gnomAD
rs200617821 CA7230003 RCV001811009	1763	S>G		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1222896246 CA390041251	1764	E>K		No	ClinGen TOPMed gnomAD
rs1318954030 CA390041218	1769	A>T		No	ClinGen gnomAD
rs375893423 CA7229997	1770	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs953620091 CA262689201	1771	W>R		No	ClinGen TOPMed
rs1360974439 CA390041195	1772	K>T		No	ClinGen gnomAD
CA390041182 rs1389090249	1774	G>R		No	ClinGen TOPMed
rs761370429 CA7229995	1776	N>Y		No	ClinGen ExAC gnomAD
rs763816993 CA7229993	1777	E>K		No	ClinGen ExAC gnomAD
CA390041151 rs1490526768	1778	M>I		No	ClinGen gnomAD
CA390041104 rs1321981607	1785	L>F		No	ClinGen TOPMed
rs1011120419 CA262689128	1786	I>T		No	ClinGen TOPMed
rs1594758947 CA390041086	1788	T>A		No	ClinGen Ensembl
rs1167836684 CA390041081 COSM957057	1788	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA7229989 rs745688508	1789	R>C		No	ClinGen ExAC TOPMed gnomAD
CA262689089 rs139477432	1789	R>H		No	ClinGen ESP TOPMed gnomAD
rs1192295823 CA390041071	1790	M>I		No	ClinGen gnomAD
rs1030785965 CA262689086	1790	M>V		No	ClinGen TOPMed
CA7229988 rs768086142	1792	L>Q		No	ClinGen ExAC gnomAD
CA390041018 rs1251681287	1794	A>G		No	ClinGen gnomAD
rs749332448 CA7229986	1795	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1356951148 CA390041004	1797	Y>H		No	ClinGen TOPMed
rs769986867 CA7229984	1800	H>P		No	ClinGen ExAC gnomAD
rs769986867 CA390040982	1800	H>R		No	ClinGen ExAC gnomAD
rs777877007 CA7229985	1800	H>Y		No	ClinGen ExAC gnomAD
CA7229982 rs781493805	1801	R>C		No	ClinGen ExAC gnomAD
CA7229983 rs781493805	1801	R>G		No	ClinGen ExAC gnomAD
rs755253000 CA7229981	1801	R>H		No	ClinGen ExAC TOPMed gnomAD
CA390040971 rs1594758877	1802	Y>C		No	ClinGen Ensembl
rs142051792 CA7229978	1805	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA262689005 rs1046495906	1805	T>S		No	ClinGen TOPMed
rs753387708 CA7229977	1806	G>A		No	ClinGen ExAC TOPMed gnomAD
rs143950158 CA7229975	1808	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1372870402 CA390040911	1812	L>F		No	ClinGen gnomAD
CA7229972 rs142187216	1813	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA390040895 rs1458297386	1814	D>G		No	ClinGen gnomAD
rs1193527563 CA390040898	1814	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7229969 rs751881161	1815	E>K		No	ClinGen ExAC gnomAD
CA390040884 rs1480466529	1816	K>E		No	ClinGen gnomAD
rs773272203 CA7229968	1817	H>Y		No	ClinGen ExAC gnomAD
rs548493652 CA7229967	1818	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7229966 rs748286261	1818	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7229964 rs200386310	1819	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1304147798 CA390040850	1821	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA262688893 rs763716590	1822	E>K		No	ClinGen TOPMed gnomAD
rs138157205 CA390040834	1824	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs138157205 CA7229958	1824	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA390040827 rs1173587715	1825	G>E		No	ClinGen gnomAD
rs370441240 CA7229955	1828	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs370441240 CA7229956	1828	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs766226678 CA7229953 RCV000756717	1829	S>N		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs773088290 CA7229952	1830	T>K		No	ClinGen ExAC TOPMed gnomAD
rs773088290 CA7229951	1830	T>M		No	ClinGen ExAC TOPMed gnomAD
rs773088290 CA390040797	1830	T>R		No	ClinGen ExAC TOPMed gnomAD
rs532526634 CA7229948	1832	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1352830843 CA390040782	1833	S>P		No	ClinGen gnomAD
CA262688783 rs1025613350	1834	F>L		No	ClinGen Ensembl
rs1340521360 CA390040759	1836	R>P		No	ClinGen gnomAD
CA390040760 rs1340521360	1836	R>Q		No	ClinGen gnomAD
rs1237768541 CA390040761	1836	R>W		No	ClinGen gnomAD
rs1327485592 CA390040757	1837	V>M		No	ClinGen gnomAD
CA7229946 rs747322463	1838	H>R		No	ClinGen ExAC TOPMed gnomAD
rs775861576 CA7229945	1840	A>D		No	ClinGen ExAC gnomAD
CA390040727 rs772509663 CA7229944	1841	F>L		No	ClinGen ExAC gnomAD
CA390040732 rs1420676524	1841	F>L		No	ClinGen gnomAD
rs1157307521 CA390040726	1842	E>K		No	ClinGen TOPMed gnomAD
rs1157307521 CA390040725	1842	E>Q		No	ClinGen TOPMed gnomAD
rs553755523 CA7229943	1843	R>G		No	ClinGen ExAC TOPMed gnomAD
rs534004149 COSM76583 CA7229941	1843	R>Q	ovary Variant assessed as Somatic; 5.233e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
CA7229942 rs553755523	1843	R>W		No	ClinGen ExAC TOPMed gnomAD
CA262688718 rs895736691	1844	E>G		No	ClinGen gnomAD
rs1474309123 CA390040708	1845	L>F		No	ClinGen gnomAD
rs1394325411 CA390040707	1845	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA7229939 rs780809373	1846	H>N		No	ClinGen ExAC TOPMed gnomAD
rs1384561485 COSM1515968 CA390040685	1849	G>C	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs751142647 CA7229937	1850	V>G		No	ClinGen ExAC gnomAD
CA7229936 rs377094747	1851	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs369630504 CA7229915	1858	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA390040600 rs1594757359	1860	T>P		No	ClinGen Ensembl
rs757007250 CA7229914	1861	R>C		No	ClinGen ExAC TOPMed gnomAD
CA390040593 rs757007250	1861	R>G		No	ClinGen ExAC TOPMed gnomAD
CA7229913 rs375479678	1861	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs763962262 CA7229912	1866	Y>F		No	ClinGen ExAC gnomAD
CA390040564 rs1238188714	1866	Y>H		No	ClinGen gnomAD
CA7229911 rs760795766	1868	G>A		No	ClinGen ExAC gnomAD
rs1271832569 CA390040530	1871	A>T		No	ClinGen gnomAD
rs775750950 CA7229910	1872	E>K		No	ClinGen ExAC gnomAD
rs1306312978 CA390040518	1873	A>T		No	ClinGen gnomAD
CA7229908 rs759894414	1879	Q>K		No	ClinGen ExAC gnomAD
rs185125059 CA7229907	1879	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
CA7229906 rs771256092	1880	E>G		No	ClinGen ExAC TOPMed gnomAD
CA390040459 rs1328396050 CA390040458	1881	V>L		No	ClinGen gnomAD
rs373473270 CA390040441	1884	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
RCV001297481 rs373473270 CA7229904	1884	A>T		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA7229901 rs779601232	1887	A>V		No	ClinGen ExAC TOPMed gnomAD
CA390040403 rs1209365743	1890	D>A		No	ClinGen gnomAD
CA7229897 rs757030587 RCV001002645	1890	D>N		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA7229896 rs753608080	1892	C>R		No	ClinGen ExAC gnomAD
CA390040377 rs1371219955	1894	G>E		No	ClinGen gnomAD
CA7229894 rs116677071	1894	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs759689339 CA7229891 COSM194073	1895	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1357134262 CA390040372	1895	R>H		No	ClinGen TOPMed gnomAD
rs1357134262 CA390040370	1895	R>L		No	ClinGen TOPMed gnomAD
CA7229890 rs147607076	1896	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1310916716 CA390040368	1896	R>W		No	ClinGen gnomAD
CA7229889 rs147013623	1897	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA262686908 rs148911293	1897	T>I		No	ClinGen ESP TOPMed gnomAD
CA390040359 rs1398484902	1898	Q>K		No	ClinGen gnomAD
CA390040357 rs1566744840	1898	Q>R		No	ClinGen Ensembl
rs763349032 CA7229888	1899	L>I		No	ClinGen ExAC gnomAD
rs773500781 CA7229887	1900	V>M		No	ClinGen ExAC gnomAD
CA390040344 rs1448965155	1901	D>N		No	ClinGen Ensembl
CA390040333 rs747851511	1902	T>K		No	ClinGen ExAC TOPMed gnomAD
CA7229886 rs747851511	1902	T>M		No	ClinGen ExAC TOPMed gnomAD
CA7229884 rs200540305	1903	A>V		No	ClinGen ExAC TOPMed gnomAD
rs745394216 CA7229882	1904	D>G		No	ClinGen ExAC TOPMed gnomAD
rs145604702 CA7229881	1906	F>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs770527904 CA7229880	1907	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7229879 rs368348495	1907	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA390040301 rs368348495	1907	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs576500528 CA7229878	1909	F>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756115510 CA7229877	1910	S>I		No	ClinGen ExAC TOPMed gnomAD
CA262686798 rs756115510	1910	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1291643280 CA390040266	1912	A>D		No	ClinGen gnomAD
rs752611530 CA7229876	1913	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs201489818 CA7229875	1913	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7229874 rs755057264	1914	D>V		No	ClinGen ExAC gnomAD
CA390040250 rs1428484387	1915	L>F		No	ClinGen gnomAD
CA7229871 rs149678681	1917	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766604416 CA7229872	1917	S>P		No	ClinGen ExAC gnomAD
CA7229869 rs374275794	1921	S>G		No	ClinGen ESP ExAC gnomAD
CA7229870 rs374275794	1921	S>R		No	ClinGen ESP ExAC gnomAD
CA7229868 rs201844140	1921	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1420592937 CA390040204	1922	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs764617663 CA390040191	1924	R>G		No	ClinGen ExAC TOPMed gnomAD
rs182057003 CA262686717	1924	R>Q		No	ClinGen 1000Genomes TOPMed
rs764617663 CA7229866	1924	R>W	Variant assessed as Somatic; 9.24e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs759057720 CA7229865	1925	Q>L		No	ClinGen ExAC gnomAD
CA390040176 rs139457633	1926	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA390040181 rs1469854717	1926	I>V		No	ClinGen gnomAD
rs1232851302 CA390040175	1927	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA390040136 rs1307874385	1932	P>S		No	ClinGen TOPMed gnomAD
CA7229850 rs754243214	1935	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1202249104 CA390040065	1941	L>P		No	ClinGen gnomAD
CA390040050 rs1468563153	1943	K>R		No	ClinGen TOPMed
CA7229847 rs772454723	1944	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs370190815 CA390040025	1946	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA390040016 rs1302137506	1948	I>V		No	ClinGen gnomAD
CA7229844 rs772947721	1949	N>S		No	ClinGen ExAC TOPMed gnomAD
CA390039999 rs1410690035	1950	A>G		No	ClinGen TOPMed
rs138039383 CA7229843 RCV000756718	1952	I>T		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1594755901 CA390039975	1954	T>P		No	ClinGen Ensembl
CA7229841 rs776627782	1955	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7229842 rs747917733 COSM285341	1955	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA7229839 rs746858620	1956	S>N		No	ClinGen ExAC gnomAD
CA7229840 rs768636719	1956	S>R		No	ClinGen ExAC gnomAD
CA390039961 rs1041944546	1956	S>R		No	ClinGen TOPMed
CA390039949 rs1594755885	1958	N>T		No	ClinGen Ensembl
rs199572062 CA7229838	1959	F>S		No	ClinGen 1000Genomes ExAC gnomAD
CA7229837 rs758361668	1964	E>G		No	ClinGen ExAC gnomAD
CA262685237 rs779077726	1966	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7229836 rs143489400	1966	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA7229835 rs779077726	1966	G>V		No	ClinGen ExAC gnomAD
CA7229834 rs144016437	1967	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1482611902 CA390039883	1968	S>C		No	ClinGen gnomAD
rs1280691745 CA390039873	1970	L>P		No	ClinGen TOPMed gnomAD
CA390039874 rs1280691745	1970	L>Q		No	ClinGen TOPMed gnomAD
CA7229833 rs529298380	1972	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs1594755834 CA390039851	1974	H>D		No	ClinGen Ensembl
rs959784550 CA262685187	1974	H>R		No	ClinGen TOPMed gnomAD
CA7229830 rs753088107	1976	A>T		No	ClinGen ExAC gnomAD
CA7229804 rs201049665	1981	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7229803 rs201049665	1981	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs146513976 CA7229801 RCV000756714	1981	R>H		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs146513976 CA7229802	1981	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7229799 rs145664609	1982	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390039746 rs1274699639	1988	M>V		No	ClinGen gnomAD
CA7229797 rs749393104	1989	S>C		No	ClinGen ExAC gnomAD
CA7229796 rs777814175	1990	R>S		No	ClinGen ExAC gnomAD
CA7229795 rs368955956	1991	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1228595311 CA390039722	1991	R>S		No	ClinGen gnomAD
rs1220872610 CA390039688	1996	E>K		No	ClinGen TOPMed
rs573846501 CA7229794	1997	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA390039672 rs1395246319	1998	W>R		No	ClinGen gnomAD
CA262684462 rs760877945	2000	A>T		No	ClinGen TOPMed gnomAD
CA7229793 rs376489437	2001	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs148593138 CA7229792	2001	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA262684428 rs148593138	2001	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1168342444 CA390039635	2003	E>G		No	ClinGen gnomAD
rs144839610 CA7229790	2004	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA7229789 rs372967907	2004	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7229791 rs144839610	2004	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA390039627 rs1454353070	2005	L>F		No	ClinGen gnomAD
CA390039625 rs1254275602	2005	L>P		No	ClinGen gnomAD
rs140490240 CA7229786	2006	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs767230972 CA7229785	2006	R>H		No	ClinGen ExAC TOPMed gnomAD
rs767230972 CA7229784	2006	R>L		No	ClinGen ExAC TOPMed gnomAD
rs767230972 CA390039621	2006	R>P		No	ClinGen ExAC TOPMed gnomAD
CA262684333 rs1027966609	2007	M>I		No	ClinGen Ensembl
CA390039576 rs1377241560	2011	V>A		No	ClinGen gnomAD
CA7229766 rs755580710	2012	C>Y		No	ClinGen ExAC gnomAD
CA390039559 rs1413431965	2013	Q>H		No	ClinGen gnomAD
CA390039562 rs1406790023	2013	Q>R		No	ClinGen gnomAD
rs752332760 CA7229765	2015	S>L		No	ClinGen ExAC gnomAD
rs754723993 CA7229763	2017	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs775701663 CA262682865	2019	S>F		No	ClinGen gnomAD
CA390039517 rs1405939052	2020	V>G		No	ClinGen TOPMed
rs1486186891 CA390039521	2020	V>L		No	ClinGen TOPMed gnomAD
rs929734499 RCV001811591 CA262682848	2021	A>P		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs1028735989 CA262682846	2022	E>D		No	ClinGen TOPMed gnomAD
CA390039501 rs367841692	2023	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA390039488 rs1327398928	2025	L>V		No	ClinGen gnomAD
CA390039444 rs1287925327	2031	Y>C		No	ClinGen gnomAD
rs745476248 COSM3956152 CA262682837	2034	S>N	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA390039422 rs1206516197	2035	G>R		No	ClinGen TOPMed gnomAD
CA390039420 rs1206516197	2035	G>W		No	ClinGen TOPMed gnomAD
CA7229758 rs373697277	2039	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA390039380 rs1345709572	2040	T>R		No	ClinGen gnomAD
CA7229756 rs776954379	2041	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1279582799 CA390039363	2043	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA390039360 rs1165149172	2043	S>R		No	ClinGen gnomAD
CA390039362 rs1279582799	2043	S>T		No	ClinGen TOPMed gnomAD
CA390039352 rs1416341754	2045	E>K		No	ClinGen gnomAD
rs906427175 COSM348969 CA262682723	2050	R>S	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA262682718 rs12888773	2051	H>Q		No	ClinGen Ensembl
rs200806426 CA7229751	2057	S>Y		No	ClinGen 1000Genomes ExAC
rs756849461 RCV001290762 CA7229750	2058	T>M		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs780791721 CA7229748	2060	S>G		No	ClinGen ExAC gnomAD
CA390039230 rs1302703654	2062	A>E		No	ClinGen gnomAD
rs1310397240 CA390039227	2063	E>K		No	ClinGen gnomAD
CA7229745 rs779889677	2064	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7229746 rs779889677	2064	R>G		No	ClinGen ExAC TOPMed gnomAD
rs121918650 CA7229744	2064	R>H		No	ClinGen ExAC TOPMed gnomAD
RCV001810627 rs143894722 CA7229743	2065	F>V		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1327732912 CA390039203	2067	A>T		No	ClinGen TOPMed
rs1454069256 CA390039175	2071	P>S		No	ClinGen TOPMed
CA7229741 rs138377308	2073	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA390039137 rs1235889026	2075	E>G		No	ClinGen gnomAD
CA7229719 rs192618182	2079	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs759910047 CA7229717	2080	Q>H		No	ClinGen ExAC gnomAD
rs146990471 CA7229716	2081	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1361547791 CA390039100	2081	I>V		No	ClinGen TOPMed
rs1164312867 CA390039095	2082	A>T		No	ClinGen TOPMed
CA7229715 rs771454363	2083	E>D		No	ClinGen ExAC gnomAD
rs1186658009 CA390039089	2083	E>K		No	ClinGen gnomAD
CA7229713 rs773712048	2084	R>I		No	ClinGen ExAC gnomAD
rs773712048 CA7229714	2084	R>K		No	ClinGen ExAC gnomAD
rs746553902 CA390039070	2086	A>S		No	ClinGen ExAC TOPMed gnomAD
rs746553902 CA7229711 COSM1227460	2086	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA7229710 rs201339590	2087	E>G		No	ClinGen 1000Genomes ExAC gnomAD
rs201339590 CA7229709	2087	E>V		No	ClinGen 1000Genomes ExAC gnomAD
CA7229687 rs771754701	2091	P>L		No	ClinGen ExAC gnomAD
rs745447608 CA7229686 CA262681626	2093	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1328912901 CA390038920	2093	E>K		No	ClinGen gnomAD
rs748216421 CA262681623	2094	E>K		No	ClinGen Ensembl
rs774068563 CA7229685	2094	E>V		No	ClinGen ExAC gnomAD
CA390038857 rs1312598730	2100	G>R		No	ClinGen gnomAD
rs1330172047 CA390038814	2103	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs749123042 CA7229683 RCV001002502	2105	S>A		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs1395474623 CA390038786	2105	S>F		No	ClinGen gnomAD
rs1456168742 CA390038780	2106	H>D		No	ClinGen TOPMed gnomAD
rs1456168742 CA390038781	2106	H>Y		No	ClinGen TOPMed gnomAD
rs1566741532 CA390038758	2107	H>L		No	ClinGen Ensembl
rs1594752693 CA390038749	2107	H>Q		No	ClinGen Ensembl
CA7229682 rs369676353	2108	A>V		No	ClinGen ESP ExAC TOPMed
rs1193748994 CA390038731	2109	A>T		No	ClinGen gnomAD
rs748245626 CA7229680	2109	A>V		No	ClinGen ExAC gnomAD
CA7229675 rs758734157	2111	E>K		No	ClinGen ExAC gnomAD
CA7229676 rs758734157	2111	E>Q		No	ClinGen ExAC gnomAD
rs750835527 CA7229674	2113	T>M		No	ClinGen ExAC gnomAD
rs762377368 CA7229672	2115	P>L		No	ClinGen ExAC TOPMed gnomAD
CA390038660 rs1212051430	2115	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs112886579 CA262681531	2116	V>G		No	ClinGen Ensembl
CA262681479 rs375155686	2120	S>F		No	ClinGen ESP TOPMed
rs773831998 CA7229668	2121	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7229667 rs770745304	2121	R>H		No	ClinGen ExAC gnomAD
CA390038603 rs1205508644	2122	L>F		No	ClinGen TOPMed
rs151232626 CA7229666	2122	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7229665 rs773195221	2124	S>R		No	ClinGen ExAC gnomAD
CA390038578 rs1384892799	2126	W>R		No	ClinGen gnomAD
CA7229664 rs769849087	2126	W>S		No	ClinGen ExAC gnomAD
CA7229663 rs747968623	2129	L>V		No	ClinGen ExAC gnomAD
rs371741651 CA7229662	2133	P>S		No	ClinGen ESP ExAC
rs368060934 CA262681428	2134	S>F		No	ClinGen ESP TOPMed
CA7229659 rs747154534	2136	P>H		No	ClinGen ExAC TOPMed gnomAD
CA262681406 rs747154534	2136	P>R		No	ClinGen ExAC TOPMed gnomAD
CA7229660 rs768567783	2136	P>T		No	ClinGen ExAC gnomAD
CA7229658 rs780235497	2137	Y>C		No	ClinGen ExAC gnomAD

No associated diseases with P11277

4 regional properties for P11277

Type	Name	Position	InterPro Accession
domain	Forkhead-associated (FHA) domain	55 - 128	IPR000253
domain	Protein kinase domain	200 - 480	IPR000719
active_site	Serine/threonine-protein kinase, active site	324 - 336	IPR008271
binding_site	Protein kinase, ATP binding site	206 - 229	IPR017441

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton Cytoplasm, cell cortex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cell junction	A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cell projection	A prolongation or process extending from a cell, e.g. a flagellum or axon.
cell surface	The external part of the cell wall and/or plasma membrane.
cortical actin cytoskeleton	The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intrinsic component of the cytoplasmic side of the plasma membrane	The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
spectrin	Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.
spectrin-associated cytoskeleton	The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane.

4 GO annotations of molecular function

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
ankyrin binding	Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
structural constituent of cytoskeleton	The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.

2 GO annotations of biological process

Name	Definition
actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
actin filament capping	The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	Homo sapiens (Human)	PR
Q01082	SPTBN1	Spectrin beta chain, non-erythrocytic 1	Homo sapiens (Human)	PR
P35609	ACTN2	Alpha-actinin-2	Homo sapiens (Human)	EV
Q08043	ACTN3	Alpha-actinin-3	Homo sapiens (Human)	SS
O43707	ACTN4	Alpha-actinin-4	Homo sapiens (Human)	SS
P12814	ACTN1	Alpha-actinin-1	Homo sapiens (Human)	SS
Q62261	Sptbn1	Spectrin beta chain, non-erythrocytic 1	Mus musculus (Mouse)	PR
P15508	Sptb	Spectrin beta chain, erythrocytic	Mus musculus (Mouse)	PR
Q9QWN8	Sptbn2	Spectrin beta chain, non-erythrocytic 2	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MTSATEFENV	GNQPPYSRIN	ARWDAPDDEL	DNDNSSARLF	ERSRIKALAD	EREVVQKKTF
70	80	90	100	110	120
TKWVNSHLAR	VSCRITDLYK	DLRDGRMLIK	LLEVLSGEML	PKPTKGKMRI	HCLENVDKAL
130	140	150	160	170	180
QFLKEQRVHL	ENMGSHDIVD	GNHRLVLGLI	WTIILRFQIQ	DIVVQTQEGR	ETRSAKDALL
190	200	210	220	230	240
LWCQMKTAGY	PHVNVTNFTS	SWKDGLAFNA	LIHKHRPDLI	DFDKLKDSNA	RHNLEHAFNV
250	260	270	280	290	300
AERQLGIIPL	LDPEDVFTEN	PDEKSIITYV	VAFYHYFSKM	KVLAVEGKRV	GKVIDHAIET
310	320	330	340	350	360
EKMIEKYSGL	ASDLLTWIEQ	TITVLNSRKF	ANSLTGVQQQ	LQAFSTYRTV	EKPPKFQEKG
370	380	390	400	410	420
NLEVLLFTIQ	SRMRANNQKV	YTPHDGKLVS	DINRAWESLE	EAEYRRELAL	RNELIRQEKL
430	440	450	460	470	480
EQLARRFDRK	AAMRETWLSE	NQRLVAQDNF	GYDLAAVEAA	KKKHEAIETD	TAAYEERVRA
490	500	510	520	530	540
LEDLAQELEK	ENYHDQKRIT	ARKDNILRLW	SYLQELLQSR	RQRLETTLAL	QKLFQDMLHS
550	560	570	580	590	600
IDWMDEIKAH	LLSAEFGKHL	LEVEDLLQKH	KLMEADIAIQ	GDKVKAITAA	TLKFTEGKGY
610	620	630	640	650	660
QPCDPQVIQD	RISHLEQCFE	ELSNMAAGRK	AQLEQSKRLW	KFFWEMDEAE	SWIKEKEQIY
670	680	690	700	710	720
SSLDYGKDLT	SVLILQRKHK	AFEDELRGLD	AHLEQIFQEA	HGMVARKQFG	HPQIEARIKE
730	740	750	760	770	780
VSAQWDQLKD	LAAFCKKNLQ	DAENFFQFQG	DADDLKAWLQ	DAHRLLSGED	VGQDEGATRA
790	800	810	820	830	840
LGKKHKDFLE	ELEESRGVME	HLEQQAQGFP	EEFRDSPDVT	HRLQALRELY	QQVVAQADLR
850	860	870	880	890	900
QQRLQEALDL	YTVFGETDAC	ELWMGEKEKW	LAEMEMPDTL	EDLEVVQHRF	DILDQEMKTL
910	920	930	940	950	960
MTQIDGVNLA	ANSLVESGHP	RSREVKQYQD	HLNTRWQAFQ	TLVSERREAV	DSALRVHNYC
970	980	990	1000	1010	1020
VDCEETSKWI	TDKTKVVEST	KDLGRDLAGI	IAIQRKLSGL	ERDVAAIQAR	VDALERESQQ
1030	1040	1050	1060	1070	1080
LMDSHPEQKE	DIGQRQKHLE	ELWQGLQQSL	QGQEDLLGEV	SQLQAFLQDL	DDFQAWLSIT
1090	1100	1110	1120	1130	1140
QKAVASEDMP	ESLPEAEQLL	QQHAGIKDEI	DGHQDSYQRV	KESGEKVIQG	QTDPEYLLLG
1150	1160	1170	1180	1190	1200
QRLEGLDTGW	NALGRMWESR	SHTLAQCLGF	QEFQKDAKQA	EAILSNQEYT	LAHLEPPDSL
1210	1220	1230	1240	1250	1260
EAAEAGIRKF	EDFLGSMENN	RDKVLSPVDS	GNKLVAEGNL	YSDKIKEKVQ	LIEDRHRKNN
1270	1280	1290	1300	1310	1320
EKAQEASVLL	RDNLELQNFL	QNCQELTLWI	NDKLLTSQDV	SYDEARNLHN	KWLKHQAFVA
1330	1340	1350	1360	1370	1380
ELASHEGWLE	NIDAEGKQLM	DEKPQFTALV	SQKLEALHRL	WDELQATTKE	KTQHLSAARS
1390	1400	1410	1420	1430	1440
SDLRLQTHAD	LNKWISAMED	QLRSDDPGKD	LTSVNRMLAK	LKRVEDQVNV	RKEELGELFA
1450	1460	1470	1480	1490	1500
QVPSMGEEGG	DADLSIEKRF	LDLLEPLGRR	KKQLESSRAK	LQISRDLEDE	TLWVEERLPL
1510	1520	1530	1540	1550	1560
AQSADYGTNL	QTVQLFMKKN	QTLQNEILGH	TPRVEDVLQR	GQQLVEAAEI	DCQDLEERLG
1570	1580	1590	1600	1610	1620
HLQSSWDRLR	EAAAGRLQRL	RDANEAQQYY	LDADEAEAWI	GEQELYVISD	EIPKDEEGAI
1630	1640	1650	1660	1670	1680
VMLKRHLRQQ	RAVEDYGRNI	KQLASRAQGL	LSAGHPEGEQ	IIRLQGQVDK	HYAGLKDVAE
1690	1700	1710	1720	1730	1740
ERKRKLENMY	HLFQLKRETD	DLEQWISEKE	LVASSPEMGQ	DFDHVTLLRD	KFRDFARETG
1750	1760	1770	1780	1790	1800
AIGQERVDNV	NAFIERLIDA	GHSEAATIAE	WKDGLNEMWA	DLLELIDTRM	QLLAASYDLH
1810	1820	1830	1840	1850	1860
RYFYTGAEIL	GLIDEKHREL	PEDVGLDAST	AESFHRVHTA	FERELHLLGV	QVQQFQDVAT
1870	1880	1890	1900	1910	1920
RLQTAYAGEK	AEAIQNKEQE	VSAAWQALLD	ACAGRRTQLV	DTADKFRFFS	MARDLLSWME
1930	1940	1950	1960	1970	1980
SIIRQIETQE	RPRDVSSVEL	LMKYHQGINA	EIETRSKNFS	ACLELGESLL	QRQHQASEEI
1990	2000	2010	2020	2030	2040
REKLQQVMSR	RKEMNEKWEA	RWERLRMLLE	VCQFSRDASV	AEAWLIAQEP	YLASGDFGHT
2050	2060	2070	2080	2090	2100
VDSVEKLIKR	HEAFEKSTAS	WAERFAALEK	PTTLELKERQ	IAERPAEETG	PQEEEGETAG
2110	2120	2130
EAPVSHHAAT	ERTSPVSLWS	RLSSSWESLQ	PEPSHPY