P11234
PR
Gene name |
RALB |
Protein name |
Ras-related protein Ral-B |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5899 |
EC number |
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for P11234
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2KE5 | NMR | - | A | 12-185 | PDB |
| 2KWI | NMR | - | A | 8-185 | PDB |
| 6ZQT | X-ray | 151 A | A/B | 1-185 | PDB |
| 6ZRN | X-ray | 148 A | A/B | 1-185 | PDB |
| AF-P11234-F1 | Predicted | AlphaFoldDB |
115 variants for P11234
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
RCV001813017 rs1689908101 |
3 | A>T | No |
ClinVar dbSNP |
|
|
CA54588834 rs927547151 |
4 | N>K | No |
ClinGen TOPMed |
|
|
CA348190443 rs1185557579 |
5 | K>R | No |
ClinGen gnomAD |
|
|
rs753362144 CA1850923 |
6 | S>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 10 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA348190582 rs1162605640 |
13 | A>T | No |
ClinGen gnomAD |
|
|
rs1411301372 CA348190601 |
14 | L>F | No |
ClinGen gnomAD |
|
|
CA1850928 rs780177402 |
17 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA348190665 rs780177402 |
17 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs754996996 CA1850930 |
26 | G>S | No |
ClinGen ExAC |
|
|
rs1329309392 CA348190890 |
30 | L>P | No |
ClinGen TOPMed |
|
|
CA348190904 rs1282975021 |
31 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 32 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA348191028 rs1463767872 |
38 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA348191933 rs1227827268 |
40 | V>I | No |
ClinGen gnomAD |
|
|
rs1413734518 CA348191947 |
42 | D>H | No |
ClinGen TOPMed |
|
|
rs1270144229 CA536070991 |
43 | Y>* | No |
ClinGen TOPMed gnomAD |
|
|
CA1850967 rs751520692 |
44 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs759371436 CA54594634 |
45 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs759371436 CA1850968 |
45 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA348191998 rs1265748358 |
49 | D>G | No |
ClinGen gnomAD |
|
|
rs1171054565 CA348192014 |
51 | Y>C | No |
ClinGen TOPMed |
|
|
CA348192027 rs1455697343 |
53 | K>M | No |
ClinGen TOPMed |
|
| TCGA novel | 53 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1395917299 CA348192060 |
58 | D>N | No |
ClinGen TOPMed |
|
|
CA1850971 rs756159101 |
69 | T>S | No |
ClinGen ExAC gnomAD |
|
|
rs1388854390 CA348192166 |
70 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
| TCGA novel | 71 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1446903439 CA348192222 |
73 | E>G | No |
ClinGen gnomAD |
|
|
CA1850975 rs745779129 |
76 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1290831341 CA348192307 |
78 | I>V | No |
ClinGen gnomAD |
|
|
CA348192319 rs1389731638 COSM1005979 |
79 | R>* | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA1850979 rs758828798 |
83 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs1385099631 CA348192411 |
85 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
rs370296136 CA54594744 |
87 | E>K | No |
ClinGen ESP TOPMed |
|
|
CA54594755 rs968397587 |
90 | L>V | No |
ClinGen TOPMed |
|
|
rs747629158 CA1850981 |
91 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA1850982 rs769286298 |
92 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs1336013794 CA348192454 |
92 | V>L | No |
ClinGen TOPMed |
|
|
rs1242408164 CA348192471 |
94 | S>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs143444584 CA1850983 |
95 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs550286535 CA1850984 |
97 | E>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA1850986 rs774104098 |
100 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA348192525 rs1182915759 |
102 | T>I | No |
ClinGen gnomAD |
|
|
CA348192533 rs1256128881 |
104 | T>A | No |
ClinGen gnomAD |
|
| TCGA novel | 104 | T>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM716027 CA1850990 rs139389446 |
106 | E>K | lung Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA348192562 rs1178283834 |
108 | R>T | No |
ClinGen TOPMed |
|
|
CA1851005 COSM177320 rs745653359 |
111 | I>T | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA54596377 rs1804270 |
113 | R>C | No |
ClinGen gnomAD |
|
|
CA1851007 rs775311402 |
113 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA348193016 rs1415101276 |
116 | A>P | No |
ClinGen gnomAD |
|
|
rs1046236799 CA54596389 |
117 | E>D | No |
ClinGen TOPMed |
|
|
CA348193067 rs1175533821 |
118 | E>D | No |
ClinGen gnomAD |
|
| TCGA novel | 122 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA348193139 rs1357506134 |
123 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1207242365 CA348193152 |
125 | V>A | No |
ClinGen TOPMed |
|
|
rs372920618 CA1851008 |
125 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs762186246 CA1851012 |
126 | V>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA1851011 rs762186246 |
126 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA348193170 rs1322940534 |
128 | N>K | No |
ClinGen TOPMed |
|
|
rs750595222 CA1851013 |
130 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA54596422 rs200211173 |
132 | L>V | No |
ClinGen 1000Genomes |
|
|
CA1851016 rs752056136 |
133 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA54596427 rs71424343 |
133 | E>K | No |
ClinGen Ensembl |
|
|
CA1851018 COSM1005981 rs141928830 |
135 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs755448540 CA1851017 |
135 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1573360347 CA348193234 |
138 | V>G | No |
ClinGen Ensembl |
|
|
rs1203529801 CA348193259 |
142 | E>G | No |
ClinGen gnomAD |
|
| TCGA novel | 142 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA348193264 rs756687512 |
143 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1851020 rs756687512 |
143 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1387220448 CA348193268 |
144 | R>G | No |
ClinGen TOPMed |
|
|
rs1573360374 CA348193282 |
145 | S>R | No |
ClinGen Ensembl |
|
|
CA348193291 rs1478441191 |
147 | A>T | No |
ClinGen gnomAD |
|
|
CA1851022 rs745475477 |
148 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA348193317 rs1463339148 |
150 | W>* | No |
ClinGen gnomAD |
|
|
CA348193319 rs1170388506 |
150 | W>C | No |
ClinGen gnomAD |
|
|
CA1851024 rs201399252 |
152 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA348193339 rs1296862435 |
153 | Q>H | No |
ClinGen Ensembl |
|
|
rs746983312 CA1851025 |
154 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
rs1436686867 CA348193348 |
155 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1436686867 CA348193347 |
155 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
CA348193354 rs1266253050 |
156 | E>Q | No |
ClinGen TOPMed |
|
|
CA54596463 rs915414317 |
157 | T>M | Variant assessed as Somatic; 4.632e-05 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs769404128 CA54596467 |
158 | S>* | No |
ClinGen Ensembl |
|
|
rs776654341 CA1851027 |
159 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs769957680 CA1851029 |
161 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763212829 CA348193390 |
162 | R>G | No |
ClinGen ExAC TOPMed |
|
|
CA1851032 rs766695594 |
162 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA1851031 rs763212829 |
162 | R>W | No |
ClinGen ExAC TOPMed |
|
|
CA348193408 rs760095690 |
165 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760095690 CA1851034 |
165 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA348193418 rs1158405394 |
166 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
rs768014302 CA1851035 |
166 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA348193412 rs768014302 |
166 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
CA54596488 rs200981856 |
167 | K>E | No |
ClinGen Ensembl |
|
|
CA348193591 rs1380068901 |
174 | R>G | No |
ClinGen gnomAD |
|
|
rs1341945275 CA348193620 |
178 | T>A | No |
ClinGen gnomAD |
|
|
rs757787374 CA1851060 |
181 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA1851061 rs766062021 |
182 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA348193668 rs1352735357 |
184 | N>K | No |
ClinGen gnomAD |
|
|
CA54598321 rs865830396 |
184 | N>S | No |
ClinGen Ensembl |
|
|
CA1851062 rs751217728 |
186 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs1229197182 CA348193678 |
186 | D>H | No |
ClinGen gnomAD |
|
|
rs1327134387 CA348193696 COSM1223048 |
188 | N>S | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs754843520 CA1851063 |
189 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA348193724 rs1317472279 |
192 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1276426100 CA348193727 |
192 | S>R | No |
ClinGen TOPMed |
|
|
rs1220471819 CA348193732 |
193 | S>N | No |
ClinGen TOPMed |
|
|
rs1280648584 CA348193736 |
193 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs781112936 CA1851064 |
194 | K>T | No |
ClinGen ExAC |
|
| TCGA novel | 196 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs756077966 CA1851067 |
198 | S>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 202 | R>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
No associated diseases with P11234
3 regional properties for P11234
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Heat shock protein 70, conserved site | 11 - 18 | IPR018181-1 |
| conserved_site | Heat shock protein 70, conserved site | 201 - 214 | IPR018181-2 |
| conserved_site | Heat shock protein 70, conserved site | 338 - 352 | IPR018181-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.2 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| G protein activity | A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). |
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cellular response to exogenous dsRNA | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. |
| cellular response to starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. |
| negative regulation of protein binding | Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. |
| positive regulation of autophagosome assembly | Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly. |
| positive regulation of epidermal growth factor receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
| positive regulation of protein binding | Any process that activates or increases the frequency, rate or extent of protein binding. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| positive regulation of protein serine/threonine kinase activity | Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. |
| Ras protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
| receptor internalization | A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. |
| regulation of exocyst assembly | Any process that modulates the frequency, rate or extent of exocyst assembly. |
| regulation of exocyst localization | Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
34 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P08642 | HRAS | GTPase HRas | Gallus gallus (Chicken) | SS |
| Q6T310 | RASL11A | Ras-like protein family member 11A | Homo sapiens (Human) | PR |
| Q8IYK8 | REM2 | GTP-binding protein REM 2 | Homo sapiens (Human) | PR |
| P55040 | GEM | GTP-binding protein GEM | Homo sapiens (Human) | PR |
| Q6IQ22 | RAB12 | Ras-related protein Rab-12 | Homo sapiens (Human) | PR |
| Q9BU20 | CPLANE2 | Ciliogenesis and planar polarity effector 2 | Homo sapiens (Human) | PR |
| Q96HU8 | DIRAS2 | GTP-binding protein Di-Ras2 | Homo sapiens (Human) | PR |
| P62070 | RRAS2 | Ras-related protein R-Ras2 | Homo sapiens (Human) | PR |
| P11233 | RALA | Ras-related protein Ral-A | Homo sapiens (Human) | PR |
| Q99578 | RIT2 | GTP-binding protein Rit2 | Homo sapiens (Human) | PR |
| P01116 | KRAS | GTPase KRas | Homo sapiens (Human) | EV |
| P01112 | HRAS | GTPase HRas | Homo sapiens (Human) | SS |
| Q61411 | Hras | GTPase HRas | Mus musculus (Mouse) | SS |
| P32883 | Kras | GTPase KRas | Mus musculus (Mouse) | SS |
| O08989 | Mras | Ras-related protein M-Ras | Mus musculus (Mouse) | PR |
| Q5PR73 | Diras2 | GTP-binding protein Di-Ras2 | Mus musculus (Mouse) | PR |
| Q91Z61 | Diras1 | GTP-binding protein Di-Ras1 | Mus musculus (Mouse) | PR |
| P62071 | Rras2 | Ras-related protein R-Ras2 | Mus musculus (Mouse) | PR |
| P35283 | Rab12 | Ras-related protein Rab-12 | Mus musculus (Mouse) | PR |
| Q08AT1 | Rasl12 | Ras-like protein family member 12 | Mus musculus (Mouse) | PR |
| A2A825 | Cplane2 | Ciliogenesis and planar polarity effector 2 | Mus musculus (Mouse) | PR |
| P55041 | Gem | GTP-binding protein GEM | Mus musculus (Mouse) | PR |
| P70425 | Rit2 | GTP-binding protein Rit2 | Mus musculus (Mouse) | PR |
| Q8VEL9 | Rem2 | GTP-binding protein REM 2 | Mus musculus (Mouse) | PR |
| Q9JIW9 | Ralb | Ras-related protein Ral-B | Mus musculus (Mouse) | PR |
| P08644 | Kras | GTPase KRas | Rattus norvegicus (Rat) | SS |
| Q9WTY2 | Rem2 | GTP-binding protein REM 2 | Rattus norvegicus (Rat) | PR |
| P20171 | Hras | GTPase HRas | Rattus norvegicus (Rat) | SS |
| Q5BJQ5 | Rit2 | GTP-binding protein Rit2 | Rattus norvegicus (Rat) | PR |
| P97538 | Mras | Ras-related protein M-Ras | Rattus norvegicus (Rat) | PR |
| P36860 | Ralb | Ras-related protein Ral-B | Rattus norvegicus (Rat) | PR |
| B7ZTR0 | cplane2 | Ciliogenesis and planar polarity effector 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| P79737 | nras | GTPase NRas | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A1DZY4 | zgc:110179 | Ras-like protein family member 11A-like | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAANKSKGQS | SLALHKVIMV | GSGGVGKSAL | TLQFMYDEFV | EDYEPTKADS | YRKKVVLDGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EVQIDILDTA | GQEDYAAIRD | NYFRSGEGFL | LVFSITEHES | FTATAEFREQ | ILRVKAEEDK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IPLLVVGNKS | DLEERRQVPV | EEARSKAEEW | GVQYVETSAK | TRANVDKVFF | DLMREIRTKK |
| 190 | 200 | ||||
| MSENKDKNGK | KSSKNKKSFK | ERCCLL |