AiPD: Autoinhibited Protein Database

P10767

Gene name	FGF6 (HST2, HSTF2)
Protein name	Fibroblast growth factor 6
Names	FGF-6 , Heparin secretory-transforming protein 2 , HST-2 , HSTF-2 , Heparin-binding growth factor 6 , HBGF-6
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2251
EC number
Protein Class

Descriptions

The mammalian fibroblast growth factor (FGF)1 family contains at least 22 distinct polypeptides (FGF1–FGF22) that are expressed in a specific spatial and temporal pattern. FGF9 was originally described as a glia-activating factor and is expressed in the nervous system as a potent mitogen for glia cells. FGF9 adopts a beta-trefoil fold similar to other FGFs, but the N- and C-terminal regions outside the beta-trefoil core are ordered (typical FGFs have disordered tails) and involved in reversible dimerization. Due to the dimerization, a significant surface area is buried in the dimer interface that occludes a major receptor binding site of FGF9 within the beta-trefoil core. Sequence alignment of FGFs shows that most of the residues that participate in this interface in FGF9 are conserved in FGF16, suggesting that FGF16 may also dimerize for autoinhibition.

Autoinhibitory domains (AIDs)

75-82 (N-terminal helix) SS

Target domain	85-207 (beta-trefoil core)
Relief mechanism
Assay

AID

75-82 (N-terminal helix)

Target domain

85-207 (beta-trefoil core)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Plotnikov AN et al. (2001) "Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition", The Journal of biological chemistry, 276, 4322-9

Autoinhibited structure

Activated structure

1 structures for P10767

Entry ID	Method	Resolution	Chain	Position	Source
AF-P10767-F1	Predicted				AlphaFoldDB

290 variants for P10767

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1263936373	1	M>?	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs921822059	2	A>V		No	TOPMed gnomAD
rs761528202	6	K>E		No	ExAC gnomAD
rs1232603436	7	L>M		No	gnomAD
rs113373093	7	L>P		No	TOPMed gnomAD
rs113373093	7	L>Q		No	TOPMed gnomAD
rs548134803	9	I>M		No	1000Genomes ExAC gnomAD
rs768003495	9	I>T		No	ExAC gnomAD
rs1462734961 COSM161061	11	M>T	NS [Cosmic]	No	cosmic curated TOPMed gnomAD
COSM4912434	11	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs775224777	12	S>Y		No	ExAC TOPMed gnomAD
COSM4655600 rs1565472687	13	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
COSM1165346 rs771915903	13	R>W	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
TCGA novel	14	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs778673100	17	R>C		No	ExAC TOPMed gnomAD
rs1194520233	17	R>H		No	TOPMed gnomAD
rs778673100	17	R>S		No	ExAC TOPMed gnomAD
rs1427949837	19	Q>*		No	gnomAD
rs1195704124	20	G>A		No	gnomAD
rs1195704124	20	G>D		No	gnomAD
rs1273570877	21	T>M		No	TOPMed gnomAD
rs1273570877	21	T>R		No	TOPMed gnomAD
rs1865753829	21	T>S		No	Ensembl
rs749489333	22	L>P		No	ExAC gnomAD
rs777927880	23	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1228094811	24	A>D		No	gnomAD
rs1214285156	24	A>S		No	TOPMed
rs756102466	25	L>F		No	ExAC TOPMed gnomAD
rs756102466	25	L>V		No	ExAC TOPMed gnomAD
rs767850309	26	V>F		No	ExAC TOPMed gnomAD
rs767850309	26	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1865753231	28	L>P		No	Ensembl
TCGA novel	29	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs139098855	29	G>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs368976437	31	L>P		No	Ensembl
rs1865753075	31	L>V		No	TOPMed gnomAD
rs1488604695	32	V>A		No	TOPMed
rs766832668	32	V>L		No	ExAC TOPMed gnomAD
rs766832668	32	V>M		No	ExAC TOPMed gnomAD
rs1403885085	33	G>S		No	TOPMed gnomAD
rs1399115761	33	G>V		No	gnomAD
TCGA novel	34	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1865752724	34	M>T		No	TOPMed
COSM4041948	35	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs11613495 VAR_018882	36	V>A		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs11613495	36	V>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200335803	36	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs775052841	37	P>S		No	ExAC TOPMed gnomAD
rs200279711	38	S>*		No	ExAC TOPMed gnomAD
rs200279711	38	S>L		No	ExAC TOPMed gnomAD
rs1865752197	39	P>L		No	TOPMed
rs770662346	40	A>S		No	ExAC gnomAD
rs749551405	40	A>V		No	ExAC TOPMed gnomAD
rs756228531	41	G>D		No	ExAC gnomAD
rs777789412	41	G>R		No	ExAC gnomAD
rs777789412	41	G>S		No	ExAC gnomAD
rs1865751863	42	T>I		No	Ensembl
rs1430310170	43	R>C		No	TOPMed
rs1430310170	43	R>G		No	TOPMed
COSM123163 rs373568166	43	R>H	upper_aerodigestive_tract Variant assessed as Somatic; MODERATE impact. breast [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
COSM6136987	43	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	44	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1347976478	47	T>M		No	gnomAD
rs1347976478	47	T>R		No	gnomAD
rs11063156	48	L>M		No	Ensembl
rs1565472603	49	L>P		No	Ensembl
rs1337877742	50	D>E		No	gnomAD
rs752067820	51	S>*		No	ExAC TOPMed gnomAD
rs752067820	51	S>L		No	ExAC TOPMed gnomAD
rs2137032801	51	S>P		No	Ensembl
rs1176086971	53	G>C		No	gnomAD
rs984090852	53	G>D		No	TOPMed gnomAD
rs1176086971	53	G>S		No	gnomAD
rs984090852	53	G>V		No	TOPMed gnomAD
rs370482414	54	W>*		No	ESP ExAC gnomAD
rs370482414	54	W>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA gnomAD
COSM6136988	54	W>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1394582963	55	G>D		No	gnomAD
rs1865750977	55	G>S		No	Ensembl
rs1321896007	56	T>A		No	TOPMed
rs575676359	56	T>I		No	1000Genomes ExAC TOPMed gnomAD
rs575676359	56	T>N		No	1000Genomes ExAC TOPMed gnomAD
rs1321896007	56	T>P		No	TOPMed
rs375947087	57	L>V		No	ESP TOPMed
rs952218723 TCGA novel	58	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs752187013	58	L>P		No	ExAC gnomAD
rs759490846	59	S>P		No	ExAC gnomAD
rs1865750174	60	R>T		No	Ensembl
rs774228889	61	S>C		No	ExAC TOPMed gnomAD
rs774228889	61	S>Y		No	ExAC TOPMed gnomAD
COSM3812038	62	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs562208785	62	R>G		No	1000Genomes ExAC TOPMed gnomAD
COSM4684537 rs892861468	62	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs17183529	63	A>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs148657794	63	A>S		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM1361678 rs148657794	63	A>T	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs17183529 VAR_018883 COSM178933	63	A>V	large_intestine [Cosmic]	No	cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1865749268	64	G>E		No	TOPMed
rs1040263555	64	G>R		No	TOPMed gnomAD
COSM386489	64	G>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2137032684	67	G>V		No	Ensembl
rs1402652408	68	E>Q		No	gnomAD
rs1865748804	68	E>V		No	Ensembl
rs1408911035	69	I>T		No	TOPMed gnomAD
rs1158215717	70	A>D		No	gnomAD
rs2137032662	70	A>T		No	Ensembl
rs1158215717	70	A>V		No	gnomAD
rs750821885	71	G>A		No	ExAC TOPMed gnomAD
rs758962655 COSM4575397	71	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1591694086	72	V>G		No	TOPMed
rs960925964	73	N>D		No	TOPMed gnomAD
rs867341297	74	W>C		No	Ensembl
rs1284475092	75	E>A		No	gnomAD
rs1448230216 COSM3460948	75	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs767044753	76	S>G		No	ExAC TOPMed gnomAD
rs1865747839	76	S>N		No	Ensembl
rs758975759	77	G>D		No	ExAC gnomAD
rs1222837591	78	Y>C		No	TOPMed gnomAD
rs201208817	78	Y>D		No	1000Genomes
COSM3986921	79	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3986920	80	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2137032576	81	G>R		No	Ensembl
rs751508514	83	K>M		No	ExAC gnomAD
rs773667611	83	K>N		No	Ensembl
rs912537551	83	K>Q		No	Ensembl
rs762919183	84	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
COSM4041946 rs373061794	84	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs2137032551	85	Q>*		No	Ensembl
rs780465055	86	R>G		No	ExAC TOPMed gnomAD
rs373272192	86	R>Q		No	ESP ExAC TOPMed gnomAD
rs780465055 COSM4041945	86	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs2137032535	87	R>W		No	Ensembl
rs1047038278	89	Y>C		No	TOPMed gnomAD
rs776927964	89	Y>H		No	ExAC TOPMed gnomAD
rs2137032516	91	N>T		No	Ensembl
rs780277371	92	V>L		No	ExAC TOPMed gnomAD
rs780277371	92	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs147431575	93	G>D		No	ESP ExAC TOPMed gnomAD
rs1865746631	94	I>L		No	gnomAD
rs201860096	94	I>M		No	1000Genomes ExAC TOPMed gnomAD
rs1412898446	94	I>S		No	gnomAD
rs1412898446	94	I>T		No	gnomAD
rs1865746631	94	I>V		No	gnomAD
rs2137032489	95	G>D		No	Ensembl
rs1476081901	95	G>R		No	TOPMed gnomAD
rs1476081901 COSM5808996	95	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs2137032482	96	F>L		No	Ensembl
rs1591694016	97	H>P		No	Ensembl
rs1187509229	97	H>Q		No	TOPMed gnomAD
rs1242246869	97	H>Y		No	gnomAD
rs757600194	98	L>F		No	ExAC gnomAD
rs1865746111	99	Q>L		No	Ensembl
rs1591694010	100	V>G		No	Ensembl
rs1214643843	100	V>L		No	gnomAD
rs1321500673	101	L>F		No	TOPMed gnomAD
rs1565472408	102	P>L		No	Ensembl
rs754609591	102	P>S		No	ExAC gnomAD
rs2137032437	103	D>A		No	Ensembl
rs758292506	103	D>N		No	ExAC TOPMed gnomAD
COSM6136989	103	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs761612677	104	G>D		No	ExAC gnomAD
rs568105919	104	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs369471848	105	R>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs199938701	105	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs369471848	105	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1865745147	106	I>N		No	TOPMed gnomAD
rs1865745147	106	I>S		No	TOPMed gnomAD
rs1162574593	107	S>G		No	gnomAD
rs1236384347	107	S>N		No	TOPMed gnomAD
rs1865744907	108	G>E		No	TOPMed
rs1419606614	108	G>R		No	gnomAD
rs1865744907	108	G>V		No	TOPMed
rs2137032384	109	T>P		No	Ensembl
rs1865744695	109	T>S		No	gnomAD
COSM468369	110	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1447145095	110	H>Q		No	gnomAD
rs1865744522	111	E>A		No	TOPMed
rs746392824	111	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1865744522	111	E>V		No	TOPMed
rs774854335	112	E>K		No	ExAC gnomAD
rs771210347	113	N>K		No	ExAC gnomAD
rs1245390500	113	N>S		No	gnomAD
rs1245390500	113	N>T		No	gnomAD
rs1193286982	113	N>Y		No	TOPMed
rs1865744105	114	P>L		No	Ensembl
rs749706231	116	S>G		No	ExAC TOPMed gnomAD
rs771531962	116	S>R		No	ExAC TOPMed gnomAD
rs1167949833	117	L>P		No	TOPMed gnomAD
rs139049599	120	I>V		No	ESP ExAC TOPMed gnomAD
rs377044251	122	T>I		No	ESP ExAC gnomAD
rs1180612567	123	V>A		No	gnomAD
rs746672335 COSM3384355	123	V>M	Variant assessed as Somatic; MODERATE impact. pancreas haematopoietic_and_lymphoid_tissue breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1476511683	124	E>K		No	TOPMed gnomAD
rs1476511683	124	E>Q		No	TOPMed gnomAD
COSM275166 rs779702937	125	R>*	Variant assessed as Somatic; HIGH impact. large_intestine urinary_tract [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM693930 rs532205756	125	R>Q	lung Variant assessed as Somatic; MODERATE impact. urinary_tract [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs2137031606 COSM3968223	126	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes
COSM939451 rs375876276	127	V>M	endometrium [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1865728671	129	S>R		No	gnomAD
TCGA novel	130	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs148135963	130	L>V		No	ESP ExAC TOPMed gnomAD
rs1318845637	131	F>S		No	TOPMed
rs1226488676	132	G>E		No	gnomAD
rs752875740	133	V>G		No	ExAC TOPMed gnomAD
rs974386309	135	S>T		No	Ensembl
rs1237427957	136	A>G		No	gnomAD
rs1865728175	136	A>T		No	Ensembl
rs1865728064	137	L>F		No	TOPMed
COSM239873 rs759669908	139	V>I	Variant assessed as Somatic; MODERATE impact. prostate [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs963085944	140	A>S		No	TOPMed gnomAD
COSM4884377 rs963085944	140	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1477139038	140	A>V		No	TOPMed gnomAD
rs1865727505	141	M>K		No	TOPMed
rs1157479065	141	M>V		No	gnomAD
rs1463359942	142	N>D		No	gnomAD
rs149005865	142	N>I		No	ESP ExAC TOPMed gnomAD
rs1422079813	143	S>G		No	TOPMed gnomAD
rs569853562	143	S>N		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	145	G>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM3460946	145	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1357543116	145	G>R		No	gnomAD
rs776856016	147	L>V		No	ExAC gnomAD
rs1565472003	147	L>W		No	Ensembl
rs138991329	148	Y>*		No	ESP ExAC TOPMed gnomAD
rs1406814273	148	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs145168026	149	A>T		No	ESP ExAC TOPMed gnomAD
rs140216440	150	T>M		No	ESP ExAC TOPMed gnomAD
COSM348670	151	P>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1565469324	152	S>I		No	TOPMed
rs1565469324	152	S>N		No	TOPMed
TCGA novel	154	Q>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3460945	154	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1332009777	155	E>A		No	TOPMed gnomAD
rs530698141	157	C>F		No	1000Genomes gnomAD
rs748009704	157	C>R		No	ExAC gnomAD
rs530698141	157	C>Y		No	1000Genomes gnomAD
rs1865604520	160	R>*		No	Ensembl
rs781060929	160	R>T		No	ExAC gnomAD
COSM939447	161	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs140796118	162	T>I		No	ESP ExAC TOPMed gnomAD
rs780317311	165	P>L		No	ExAC gnomAD
rs1379688841	167	N>K		No	TOPMed gnomAD
COSM4397202	169	N>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1027205381	170	A>V		No	Ensembl
rs542608820	171	Y>*		No	1000Genomes ExAC TOPMed gnomAD
rs372503617	172	E>*		No	ESP ExAC TOPMed gnomAD
rs760889331	172	E>G		No	ExAC TOPMed gnomAD
rs372503617	172	E>K		No	ESP ExAC TOPMed gnomAD
rs1865603501	173	S>*		No	Ensembl
rs7961645	174	D>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1013679511	174	D>E		No	TOPMed gnomAD
VAR_018884 COSM4147045 RCV001638856 rs7961645	174	D>V	thyroid [Cosmic]	No	cosmic curated ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	176	Y>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1865603148	177	Q>*		No	Ensembl
COSM693931	177	Q>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2137025069	177	Q>R		No	Ensembl
rs538985259	180	Y>H		No	ExAC TOPMed gnomAD
rs1865602716	181	I>T		No	TOPMed gnomAD
rs1337930478	181	I>V		No	TOPMed gnomAD
rs748123118	182	A>S		No	ExAC gnomAD
TCGA novel	182	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs746850556 COSM3764418	187	G>R	Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs71583765	188	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM3688207 rs71583765	188	R>Q	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs142642694 COSM431121	188	R>W	large_intestine breast [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs757215677	189	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1324420921	189	V>L		No	TOPMed
rs372807700 COSM1252416	191	R>Q	Variant assessed as Somatic; MODERATE impact. oesophagus [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ESP NCI-TCGA TOPMed gnomAD
rs17183778 VAR_018885	191	R>W		No	UniProt ESP ExAC TOPMed dbSNP gnomAD
rs868450985	192	G>S		No	Ensembl
rs754902494	192	G>V		No	ExAC TOPMed gnomAD
rs756639377	193	S>R		No	ExAC TOPMed gnomAD
rs147421559	195	V>A		No	1000Genomes ExAC TOPMed gnomAD
rs147421559	195	V>G		No	1000Genomes ExAC TOPMed gnomAD
rs1214676658	195	V>L		No	Ensembl
rs772957912	196	S>F		No	ExAC gnomAD
rs567606742	197	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs567606742	197	P>Q		No	1000Genomes ExAC TOPMed gnomAD
rs567606742	197	P>R		No	1000Genomes ExAC TOPMed gnomAD
rs1228309395	198	I>N		No	TOPMed gnomAD
rs2137024991	198	I>V		No	Ensembl
rs768516368	199	M>I		No	ExAC gnomAD
rs368545163	200	T>I		No	ESP ExAC TOPMed gnomAD
rs775289727	201	V>I		No	ExAC TOPMed gnomAD
rs771816989	202	T>S		No	ExAC gnomAD
rs936944465	203	H>L		No	Ensembl
COSM299936	203	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs746093109	203	H>Y		No	ExAC gnomAD
rs1370920223	207	R>S		No	TOPMed gnomAD
rs144536126	208	I>T		No	ESP ExAC TOPMed gnomAD

No associated diseases with P10767

No regional properties for P10767

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P10767

Functions

		Description
EC Number
Subcellular Localization	Secreted, extracellular space
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
sarcolemma	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.

2 GO annotations of molecular function

Name	Definition
fibroblast growth factor receptor binding	Binding to a fibroblast growth factor receptor (FGFR).
growth factor activity	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

11 GO annotations of biological process

Name	Definition
angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
animal organ morphogenesis	Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
cartilage condensation	The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
cell differentiation	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
fibroblast growth factor receptor signaling pathway	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
myoblast differentiation	The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
positive regulation of cell division	Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
regulation of cell migration	Any process that modulates the frequency, rate or extent of cell migration.

28 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P48801	FGF3	Fibroblast growth factor 3	Gallus gallus (Chicken)	SS
O15520	FGF10	Fibroblast growth factor 10	Homo sapiens (Human)	SS
O43320	FGF16	Fibroblast growth factor 16	Homo sapiens (Human)	EV SS
P11487	FGF3	Fibroblast growth factor 3	Homo sapiens (Human)	SS
P31371	FGF9	Fibroblast growth factor 9	Homo sapiens (Human)	EV
Q92914	FGF11	Fibroblast growth factor 11	Homo sapiens (Human)	SS
Q9HCT0	FGF22	Fibroblast growth factor 22	Homo sapiens (Human)	SS
Q9NP95	FGF20	Fibroblast growth factor 20	Homo sapiens (Human)	SS
Q9NSA1	FGF21	Fibroblast growth factor 21	Homo sapiens (Human)	PR
P08620	FGF4	Fibroblast growth factor 4	Homo sapiens (Human)	PR
Q9ESS2	Fgf22	Fibroblast growth factor 22	Mus musculus (Mouse)	SS
O35565	Fgf10	Fibroblast growth factor 10	Mus musculus (Mouse)	SS
P54130	Fgf9	Fibroblast growth factor 9	Mus musculus (Mouse)	SS
Q9JJN1	Fgf21	Fibroblast growth factor 21	Mus musculus (Mouse)	PR
Q9ESL8	Fgf16	Fibroblast growth factor 16	Mus musculus (Mouse)	SS
Q9ESL9	Fgf20	Fibroblast growth factor 20	Mus musculus (Mouse)	SS
P11403	Fgf4	Fibroblast growth factor 4	Mus musculus (Mouse)	PR
P61329	Fgf12	Fibroblast growth factor 12	Mus musculus (Mouse)	PR
P05524	Fgf3	Fibroblast growth factor 3	Mus musculus (Mouse)	SS
P21658	Fgf6	Fibroblast growth factor 6	Mus musculus (Mouse)	SS
Q95L12	FGF9	Fibroblast growth factor 9	Sus scrofa (Pig)	SS
Q9EST9	Fgf20	Fibroblast growth factor 20	Rattus norvegicus (Rat)	SS
O54769	Fgf16	Fibroblast growth factor 16	Rattus norvegicus (Rat)	SS
P36364	Fgf9	Fibroblast growth factor 9	Rattus norvegicus (Rat)	SS
P70492	Fgf10	Fibroblast growth factor 10	Rattus norvegicus (Rat)	SS
Q6PBT8	fgf1	Putative fibroblast growth factor 1	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q2HXK8	fgf16	Fibroblast growth factor 16	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
P48802	fgf3	Fibroblast growth factor 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MALGQKLFIT	MSRGAGRLQG	TLWALVFLGI	LVGMVVPSPA	GTRANNTLLD	SRGWGTLLSR
70	80	90	100	110	120
SRAGLAGEIA	GVNWESGYLV	GIKRQRRLYC	NVGIGFHLQV	LPDGRISGTH	EENPYSLLEI
130	140	150	160	170	180
STVERGVVSL	FGVRSALFVA	MNSKGRLYAT	PSFQEECKFR	ETLLPNNYNA	YESDLYQGTY
190	200
IALSKYGRVK	RGSKVSPIMT	VTHFLPRI