P10157
Gene name |
ETS2 |
Protein name |
Protein C-ets-2 |
Names |
|
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:396250 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
369-453 (ETS domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
369-453 (ETS domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Garvie CW et al. (2002) "Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships", The Journal of biological chemistry, 277, 45529-36
- Nelson ML et al. (2010) "Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP", Proceedings of the National Academy of Sciences of the United States of America, 107, 10026-31
- Ning S et al. (2022) "The auto-inhibition mechanism of transcription factor Ets-1 induced by phosphorylation on the intrinsically disordered region", Computational and structural biotechnology journal, 20, 1132-1141
- Newman JA et al. (2015) "Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2", The Journal of biological chemistry, 290, 8539-49
- Samorodnitsky D et al. (2015) "A Role for Autoinhibition in Preventing Dimerization of the Transcription Factor ETS1", The Journal of biological chemistry, 290, 22101-10
- Basuyaux JP et al. (1997) "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner", The Journal of biological chemistry, 272, 26188-95
- Shiina M et al. (2015) "A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions", Journal of molecular biology, 427, 1655-69
- Babayeva ND et al. (2010) "Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA", Cell cycle (Georgetown, Tex.), 9, 3054-62
- Leprivier G et al. (2009) "Ets-1 p51 and p42 isoforms differentially modulate Stromelysin-1 promoter according to induced DNA bend orientation", Nucleic acids research, 37, 4341-52
Autoinhibited structure
Activated structure
1 structures for P10157
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P10157-F1 | Predicted | AlphaFoldDB |
12 variants for P10157
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1057909292 | 19 | Y>H | No | Ensembl | |
| rs739568810 | 108 | L>W | No | Ensembl | |
| rs740346689 | 137 | M>R | No | Ensembl | |
| rs738912820 | 198 | S>T | No | Ensembl | |
| rs740748661 | 206 | T>P | No | Ensembl | |
| rs15377341 | 210 | I>M | No | Ensembl | |
| rs1059479269 | 226 | L>F | No | Ensembl | |
| rs318138059 | 354 | Q>K | No | Ensembl | |
| rs734506671 | 370 | S>R | No | Ensembl | |
| rs731999948 | 412 | R>G | No | Ensembl | |
| rs734179509 | 413 | W>G | No | Ensembl | |
| rs313938946 | 460 | L>R | No | Ensembl |
No associated diseases with P10157
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| RNA polymerase II-specific DNA-binding transcription factor binding | Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| branching involved in blood vessel morphogenesis | The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. |
| coronary artery morphogenesis | The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle. |
| ectodermal cell fate commitment | The cell differentiation process that results in commitment of a cell to become part of the ectoderm. |
| mesoderm development | The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| primitive streak formation | The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
33 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KIC2 | ETV1 | ETS translocation variant 1 | Bos taurus (Bovine) | SS |
| A1A4L6 | ETS2 | Protein C-ets-2 | Bos taurus (Bovine) | SS |
| Q90837 | ERG | Transcriptional regulator Erg | Gallus gallus (Chicken) | SS |
| P15062 | ETS1 | Transforming protein p68/c-ets-1 | Gallus gallus (Chicken) | SS |
| A2T762 | ETV3 | ETS translocation variant 3 | Pan troglodytes (Chimpanzee) | PR |
| Q04688 | Ets97D | DNA-binding protein Ets97D | Drosophila melanogaster (Fruit fly) | PR |
| P50548 | ERF | ETS domain-containing transcription factor ERF | Homo sapiens (Human) | PR |
| P41970 | ELK3 | ETS domain-containing protein Elk-3 | Homo sapiens (Human) | SS |
| P41161 | ETV5 | ETS translocation variant 5 | Homo sapiens (Human) | SS |
| P43268 | ETV4 | ETS translocation variant 4 | Homo sapiens (Human) | EV |
| Q06546 | GABPA | GA-binding protein alpha chain | Homo sapiens (Human) | SS |
| P28324 | ELK4 | ETS domain-containing protein Elk-4 | Homo sapiens (Human) | EV |
| P41162 | ETV3 | ETS translocation variant 3 | Homo sapiens (Human) | PR |
| P14921 | ETS1 | Protein C-ets-1 | Homo sapiens (Human) | EV |
| P50549 | ETV1 | ETS translocation variant 1 | Homo sapiens (Human) | EV |
| P11308 | ERG | Transcriptional regulator ERG | Homo sapiens (Human) | EV |
| P19419 | ELK1 | ETS domain-containing protein Elk-1 | Homo sapiens (Human) | EV |
| P15036 | ETS2 | Protein C-ets-2 | Homo sapiens (Human) | EV |
| P41971 | Elk3 | ETS domain-containing protein Elk-3 | Mus musculus (Mouse) | EV |
| Q00422 | Gabpa | GA-binding protein alpha chain | Mus musculus (Mouse) | EV |
| P41969 | Elk1 | ETS domain-containing protein Elk-1 | Mus musculus (Mouse) | PR |
| P28322 | Etv4 | ETS translocation variant 4 | Mus musculus (Mouse) | SS |
| P27577 | Ets1 | Protein C-ets-1 | Mus musculus (Mouse) | EV |
| P70459 | Erf | ETS domain-containing transcription factor ERF | Mus musculus (Mouse) | PR |
| Q9CXC9 | Etv5 | ETS translocation variant 5 | Mus musculus (Mouse) | SS |
| P41158 | Elk4 | ETS domain-containing protein Elk-4 | Mus musculus (Mouse) | PR |
| P41164 | Etv1 | ETS translocation variant 1 | Mus musculus (Mouse) | SS |
| P81270 | Erg | Transcriptional regulator ERG | Mus musculus (Mouse) | SS |
| P15037 | Ets2 | Protein C-ets-2 | Mus musculus (Mouse) | SS |
| P41156 | Ets1 | Protein C-ets-1 | Rattus norvegicus (Rat) | SS |
| A4GTP4 | Elk1 | ETS domain-containing protein Elk-1 | Rattus norvegicus (Rat) | PR |
| Q9PUQ1 | etv4 | ETS translocation variant 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A3FEM2 | fev | Protein FEV | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEFAIRNMD | QVAPVSNMYR | GMLKRQPAFD | TFDSSNSLFA | GYFLSLNEDQ | TLQEVPTGFD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| STSYESNNCE | LPLLTPCSKA | VMSQALKDTF | SGFTKEQCRL | GIPNNPWLWT | EQHVCQWLAW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ATNEFSLANV | NIHQFLMSGQ | DLCNLGKERF | LELAPDYVGD | ILWEHLEQMI | KDSQEKTQDQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YVESSHLTSV | PHWVNNNSLT | VNVDQTPYGI | QMPGYPKALS | YPKPNLLSDI | CQTSTGPNLL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SPEQDFSLFP | KTQVDAVSVN | YCTVNQDFTR | SNLNLLIDNS | GKLREHESSE | SGAESYESSD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SMLQSWNSQS | SLVDLQRVPS | YESFEDDCSQ | SLCMSKPTMS | FKDYIQDRSD | PVEQGKPVIP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AAILAGFTGS | GPIQLWQFLL | ELLTDKSCQS | FISWTGDGWE | FKLADPDEVA | RRWGRRKNKP |
| 430 | 440 | 450 | 460 | 470 | |
| KMNYEKLSRG | LRYYYDKNII | HKTSGKRYVY | RFVCDLQNLL | GYTAEELHAM | LGVQPDTED |