P10105
Gene name |
lab |
Protein name |
Homeotic protein labial |
Names |
F24, F90-2 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG1264 |
EC number |
|
Protein Class |
HOMEOBOX PROTEIN ROUGH-RELATED (PTHR45946) |
Descriptions
lab is a member of the Homeotic complex (HOX) family of homeoproteins that are required for specifying cell fates and morphological differences along the anterior-posterior axes of most animals. The lab hexapeptide(also called YPWM motif or pentapeptide) inhibits lab function and activates inappropriate target genes in vivo by inhibiting DNA binding. LAB-EXD interactions functions to remove the inhibitory effect of the hexapeptide and to enhance DNA binding to relevant target sequences by cooperative interactions.
Autoinhibitory domains (AIDs)
Target domain |
505-569 (Homeodomain) |
Relief mechanism |
Partner binding |
Assay |
Mutagenesis experiment, Deletion assay |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P10105
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P10105-F1 | Predicted | AlphaFoldDB |
No variants for P10105
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P10105 | |||||
No associated diseases with P10105
4 regional properties for P10105
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Homeobox domain | 505 - 569 | IPR001356 |
| conserved_site | Homeobox, conserved site | 540 - 563 | IPR017970 |
| domain | Homeobox domain, metazoa | 529 - 540 | IPR020479-1 |
| domain | Homeobox domain, metazoa | 544 - 563 | IPR020479-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR45946 | HOMEOBOX PROTEIN ROUGH-RELATED |
| PANTHER Subfamily | PTHR45946:SF4 | HOMEOBOX PROTEIN ROUGH-RELATED |
| PANTHER Protein Class | homeodomain transcription factor | |
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| brain segmentation | Division of the brain into a series of semi-repetitive parts or segments. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cell fate determination | A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. |
| head morphogenesis | The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. |
| midgut development | The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P23459 | HOXD8 | Homeobox protein Hox-D8 | Gallus gallus (Chicken) | PR |
| A2T6Z0 | HOXB1 | Homeobox protein Hox-B1 | Pan troglodytes (Chimpanzee) | SS |
| P31268 | HOXA7 | Homeobox protein Hox-A7 | Homo sapiens (Human) | SS |
| P14653 | HOXB1 | Homeobox protein Hox-B1 | Homo sapiens (Human) | SS |
| P49639 | HOXA1 | Homeobox protein Hox-A1 | Homo sapiens (Human) | SS |
| P09022 | Hoxa1 | Homeobox protein Hox-A1 | Mus musculus (Mouse) | SS |
| O08656 | Hoxa1 | Homeobox protein Hox-A1 | Rattus norvegicus (Rat) | SS |
| A2D649 | HOXB1 | Homeobox protein Hox-B1 | Macaca mulatta (Rhesus macaque) | SS |
| Q28IU6 | hoxd1 | Homeobox protein Hox-D1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q8JH55 | hoxb8b | Homeobox protein Hox-B8b | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| F1Q4R9 | meox1 | Homeobox protein MOX-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMDVSSMYGN | HPHHHHPHAN | AYDGYSTTTA | SAANASSYFA | PQQHQPHLQL | QQQQQHQHLQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QPQQHLTYNG | YESSSPGNYY | PQQQAQLTPP | PTSSHQVVQQ | HQQQQQAQQQ | QLYPHSHLFS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSAAEYGITT | STTTGNPGTP | LHPSSHSPAD | SYYESDSVHS | YYATAAVATV | APPSNSSPIT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AANASATSNT | QQQQQQAAII | SSENGMMYTN | LDCMYPTAQA | QAPVHGYAGQ | IEEKYAAVLH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ASYAPGMVLE | DQDPMMQQAT | QSQMWHHQQH | LAGSYALDAM | DSLGMHAHMH | HGLPHGHLGN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LANNPHQQQP | QVQQQQQQPH | QQPQHPQNQS | PAAHQQHHQN | SVSPNGGMNR | QQRGGVISPG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSTSSSTSAS | NGAHPASTQS | KSPNHSSSIP | TYKWMQLKRN | VPKPQAPSYL | PAPKLPASGI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ASMHDYQMNG | QLDMCRGGGG | GGSGVGNGPV | GVGGNGSPGI | GGVLSVQNSL | IMANSAAAAG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SAHPNGMGVG | LGSGSGLSSC | SLSSNTNNSG | RTNFTNKQLT | ELEKEFHFNR | YLTRARRIEI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ANTLQLNETQ | VKIWFQNRRM | KQKKRVKEGL | IPADILTQHS | TSVISEKPPQ | QQQPQPPELQ |
| 610 | 620 | 630 | |||
| LKSQGSDLGG | NELATGAPST | PTTAMTLTAP | TSKQS |