P0DOY1
SS
Gene name |
Dnmt3c (Gm14490) |
Protein name |
DNA |
Names |
cytosine-5-methyltransferase 3C , Dnmt3c , EC 2.1.1.37 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
|
EC number |
2.1.1.37: Methyltransferases |
Protein Class |
|
Descriptions
Oligomerization of DNMT3B, a mammalian de novo DNA methyltransferase, critically regulates its chromatin targeting and DNA methylation activities. The ADD domain of DNMT3B interacts with the MTase domain to form an autoinhibitory conformation, regulating the dynamic assembly of DNMT3B and its DNA methylation activities.
Autoinhibitory domains (AIDs)
Target domain |
462-740 (Methyltransferase domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0DOY1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0DOY1-F1 | Predicted | AlphaFoldDB |
39 variants for P0DOY1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs234220151 | 5 | S>G | No | EVA | |
| rs255529070 | 6 | R>G | No | EVA | |
| rs27385251 | 51 | N>S | No | EVA | |
| rs230037958 | 72 | V>I | No | EVA | |
| rs27385222 | 77 | G>R | No | EVA | |
| rs3392377728 | 90 | S>I | No | EVA | |
| rs27385221 | 112 | P>T | No | EVA | |
| rs50004177 | 129 | S>P | No | EVA | |
| rs27385211 | 159 | D>H | No | EVA | |
| rs224011326 | 199 | A>S | No | EVA | |
| rs27385200 | 203 | L>P | No | EVA | |
| rs264294806 | 208 | E>K | No | EVA | |
| rs27385199 | 212 | R>C | No | EVA | |
| rs256744657 | 270 | R>H | No | EVA | |
| rs108506682 | 275 | P>S | No | EVA | |
| rs108284820 | 281 | S>P | No | EVA | |
| rs108057582 | 284 | K>R | No | EVA | |
| rs3388599198 | 285 | R>L | No | EVA | |
| rs3388599205 | 290 | S>N | No | EVA | |
| rs108358352 | 305 | Q>R | No | EVA | |
| rs108042250 | 309 | D>E | No | EVA | |
| rs3388605208 | 347 | R>S | No | EVA | |
| rs3388586573 | 389 | C>S | No | EVA | |
| rs3388598215 | 391 | E>G | No | EVA | |
| rs3388604268 | 400 | E>K | No | EVA | |
| rs224935600 | 402 | V>A | No | EVA | |
| rs3388597489 | 413 | C>S | No | EVA | |
| rs585760676 | 423 | R>Q | No | EVA | |
| rs3388586569 | 451 | Y>C | No | EVA | |
| rs3388586517 | 459 | R>G | No | EVA | |
| rs3388599174 | 460 | R>G | No | EVA | |
| rs216420980 | 503 | V>I | No | EVA | |
| rs3392117292 | 543 | C>* | No | EVA | |
| rs3392117292 | 543 | C>* | No | EVA | |
| rs3392245897 | 543 | C>* | No | EVA | |
| rs3392438676 | 545 | N>I | No | EVA | |
| rs3392431973 | 547 | V>D | No | EVA | |
| rs3392257291 | 550 | G>D | No | EVA | |
| rs3388602151 | 668 | I>F | No | EVA |
No associated diseases with P0DOY1
10 regional properties for P0DOY1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 359 - 515 | IPR000008 |
| domain | Protein kinase domain | 863 - 1122 | IPR000719 |
| domain | AGC-kinase, C-terminal | 1123 - 1190 | IPR000961 |
| active_site | Serine/threonine-protein kinase, active site | 984 - 996 | IPR008271 |
| domain | HR1 rho-binding domain | 28 - 103 | IPR011072-1 |
| domain | HR1 rho-binding domain | 142 - 220 | IPR011072-2 |
| domain | HR1 rho-binding domain | 242 - 323 | IPR011072-3 |
| binding_site | Protein kinase, ATP binding site | 869 - 892 | IPR017441 |
| domain | Protein kinase, C-terminal | 1143 - 1185 | IPR017892 |
| domain | Serine/threonine-protein kinase N, first HR1 domain | 37 - 100 | IPR037313 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.37 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA (cytosine-5-)-methyltransferase activity | Catalysis of the reaction |
| DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates | Catalysis of the reaction |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| metal ion binding | Binding to a metal ion. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| homologous chromosome pairing at meiosis | The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. |
| male meiosis I | A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| piRNA-mediated retrotransposon silencing by heterochromatin formation | A retrotransposon silencing mechanism in which a piRNA triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription. |
| retrotransposon silencing by heterochromatin formation | A retrotransposon silencing mechanism involving heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UBC3 | DNMT3B | DNA | Homo sapiens (Human) | EV |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRGGSRHLSN | EEDVSGCEDC | IIISGTCSDQ | SSDPKTVPLT | QVLEAVCTVE | NRGCRTSSQP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKRKASSLIS | YVQDLTGDGD | EDRDGEVGGS | SGSGTPVMPQ | LFCETRIPSK | TPAPLSWQAN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TSASTPWLSP | ASPYPIIDLT | DEDVIPQSIS | TPSVDWSQDS | HQEGMDTTQV | DAESRDGGNI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EYQVSADKLL | LSQSCILAAF | YKLVPYRESI | YRTLEKARVR | AGKACPSSPG | ESLEDQLKPM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LEWAHGGFKP | TGIEGLKPNK | KQPENKSRRR | TTNDPAASES | SPPKRLKTNS | YGGKDRGEDE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESREQMASDV | TNNKGNLEDH | CLSCGRKDPV | SFHPLFEGGL | CQSCRDRFLE | LFYMYDEDGY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QSYCTVCCEG | RELLLCSNTS | CCRCFCVECL | EVLVGAGTAE | DVKLQEPWSC | YMCLPQRCHG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLRRRKDWNM | RLQDFFTTDP | DLEEFEPPKL | YPAIPAAKRR | PIRVLSLFDG | IATGYLVLKE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LGIKVEKYIA | SEVCAESIAV | GTVKHEGQIK | YVDDIRNITK | EHIDEWGPFD | LVIGGSPCND |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LSCVNPVRKG | LFEGTGRLFF | EFYRLLNYSC | PEEEDDRPFF | WMFENVVAME | VGDKRDISRF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LECNPVMIDA | IKVSAAHRAR | YFWGNLPGMN | RPVMASKNDK | LELQDCLEFS | RTAKLKKVQT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ITTKSNSIRQ | GKNQLFPVVM | NGKDDVLWCT | ELERIFGFPE | HYTDVSNMGR | GARQKLLGRS |
| 730 | |||||
| WSVPVIRHLF | APLKDHFACE |