P0DME0
SS
Gene name |
SETSIP (SETP18) |
Protein name |
Protein SETSIP |
Names |
SET pseudogene protein 18 , SET similar protein , Similar to SET translocation protein |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:646817 |
EC number |
|
Protein Class |
|
Descriptions
Template-activating factor I (TAF-I) is a multifunctional protein that plays a role in apoptosis, transcription, nucleosome assembly, and histone chaperoning. In human and murine cells, two TAF-I subtypes exist, namely TAF-Iɑ and TAF-Iβ. In comparison to the histone chaperone activity of TAF-Iβ, TAF-Iɑ exhibits reduced histone chaperone activity due to the N-terminal region of TAF-Iɑ autoinhibiting its activity via intramolecular interaction with its C-terminal region. The replacement of basic amino acids within the N-terminal region with alanines disrupts the intramolecular interactions between the N- and C-terminal regions, enhancing the histone chaperone activity to a similar extent to that of TAF-Iβ.
Autoinhibitory domains (AIDs)
Target domain |
248-302 (C-terminal regions) |
Relief mechanism |
Others |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0DME0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0DME0-F1 | Predicted | AlphaFoldDB |
No variants for P0DME0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0DME0 | |||||
No associated diseases with P0DME0
No regional properties for P0DME0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P0DME0 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| endothelial cell differentiation | The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. |
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O19110 | TSPY1 | Testis-specific Y-encoded protein 1 | Bos taurus (Bovine) | PR |
| Q8N831 | TSPYL6 | Testis-specific Y-encoded-like protein 6 | Homo sapiens (Human) | PR |
| Q9H2G4 | TSPYL2 | Testis-specific Y-encoded-like protein 2 | Homo sapiens (Human) | PR |
| Q99457 | NAP1L3 | Nucleosome assembly protein 1-like 3 | Homo sapiens (Human) | PR |
| P55209 | NAP1L1 | Nucleosome assembly protein 1-like 1 | Homo sapiens (Human) | PR |
| Q01534 | TSPY1 | Testis-specific Y-encoded protein 1 | Homo sapiens (Human) | PR |
| P0CV99 | TSPY4 | Testis-specific Y-encoded protein 4 | Homo sapiens (Human) | PR |
| P0CV98 | TSPY3 | Testis-specific Y-encoded protein 3 | Homo sapiens (Human) | PR |
| P0CW00 | TSPY8 | Testis-specific Y-encoded protein 8 | Homo sapiens (Human) | PR |
| P0CW01 | TSPY10 | Testis-specific Y-encoded protein 10 | Homo sapiens (Human) | PR |
| A6NKD2 | TSPY2 | Testis-specific Y-encoded protein 2 | Homo sapiens (Human) | PR |
| Q01105 | SET | Protein SET | Homo sapiens (Human) | SS |
| Q9H489 | TSPY26P | Putative testis-specific Y-encoded-like protein 3 | Homo sapiens (Human) | PR |
| Q9EQU5 | Set | Protein SET | Mus musculus (Mouse) | EV |
| Q63945 | Set | Protein SET | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPKRQSPLP | LQKKKPRPPP | ALGLEETSAS | AGLPKKGEKE | QQEAIEHIDE | VQNEIDRLNE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QDSEEILKVE | QKYNKLRQPF | FQKRSELIAK | IPNFGVTTFV | NHPQVSSLLG | EEDEEALHYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TKVEVTEFED | IKSGYRIDFY | FDENPYFENK | VFSKEFHLNE | SGDPSSKSTK | IKWKSGKDVT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KRSSQTQNKA | SRKRQHEEPE | SFFTWFTDHS | DAGADELEEV | IKDDIWPNPL | QYYLVPDMDD |
| 250 | 260 | 270 | 280 | 290 | |
| EEGGEDDDDD | DDDGDEGEEE | LEDIDEGDED | EGEEDEDDDE | GEEGEEDEGE | DD |