P0CW01

PR
Gene name
TSPY10
Protein name
Testis-specific Y-encoded protein 10
Names
Species
Homo sapiens (Human)
KEGG Pathway
hsa:728137
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

59-173 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CW01

Entry ID Method Resolution Chain Position Source
AF-P0CW01-F1 Predicted AlphaFoldDB

17 variants for P0CW01

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1603145591
CA414974447
 35 K>N No ClinGen
Ensembl
CA414974989
rs1603145604
 74 V>G No ClinGen
Ensembl
rs1603145607
CA414975016
 76 V>G No ClinGen
Ensembl
rs1603145614
CA414975170
 88 E>G No ClinGen
Ensembl
rs1603145619
CA414975186
 89 E>G No ClinGen
Ensembl
rs1353461329
CA414975451
 109 L>P No ClinGen
gnomAD
rs1556185323
CA414975744
 131 S>T No ClinGen
Ensembl
CA414975936
rs1401946011
 144 H>Q No ClinGen
gnomAD
rs1556185358
CA414975964
 147 R>C No ClinGen
Ensembl
CA414976207
rs1278882587
 164 A>S No ClinGen
gnomAD
CA414976604
rs1603145682
 190 E>G No ClinGen
Ensembl
CA414977164
rs1225448270
 228 R>G No ClinGen
gnomAD
rs1556185436
CA414977292
 237 W>* No ClinGen
Ensembl
CA414977427
rs1556185448
 247 R>C No ClinGen
Ensembl
CA414977745
rs1556185461
 269 S>F No ClinGen
Ensembl
TCGA novel 302 G>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs746060619
CA10572532
 304 S>F No ClinGen
ExAC

No associated diseases with P0CW01

1 regional properties for P0CW01

Type Name Position InterPro Accession
conserved_site TATA-box binding protein, conserved site 246 - 295 IPR030491

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
gonadal mesoderm development The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O19110 TSPY1 Testis-specific Y-encoded protein 1 Bos taurus (Bovine) PR
Q99457 NAP1L3 Nucleosome assembly protein 1-like 3 Homo sapiens (Human) PR
P55209 NAP1L1 Nucleosome assembly protein 1-like 1 Homo sapiens (Human) PR
Q01534 TSPY1 Testis-specific Y-encoded protein 1 Homo sapiens (Human) PR
P0CV99 TSPY4 Testis-specific Y-encoded protein 4 Homo sapiens (Human) PR
P0CV98 TSPY3 Testis-specific Y-encoded protein 3 Homo sapiens (Human) PR
P0CW00 TSPY8 Testis-specific Y-encoded protein 8 Homo sapiens (Human) PR
A6NKD2 TSPY2 Testis-specific Y-encoded protein 2 Homo sapiens (Human) PR
Q8N831 TSPYL6 Testis-specific Y-encoded-like protein 6 Homo sapiens (Human) PR
Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 Homo sapiens (Human) PR
P0DME0 SETSIP Protein SETSIP Homo sapiens (Human) SS
Q01105 SET Protein SET Homo sapiens (Human) SS
Q9H489 TSPY26P Putative testis-specific Y-encoded-like protein 3 Homo sapiens (Human) PR
Q9EQU5 Set Protein SET Mus musculus (Mouse) EV
Q9R1M3 Tspy1 Testis-specific Y-encoded protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MRPEGSLTYR VPERLRQGFC GVGRAAQALV CASAKEGTAF RMEAVQEGAA GVESEQAALG
70 80 90 100 110 120
EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP GPMTPESALE ELLAVQVELE
130 140 150 160 170 180
PVNAQARKAF SRQREKMERR RKPHLDRRGA VIQSVPGFWA NVIANHPQMS ALITDEDEDM
190 200 210 220 230 240
LSYMVSLEVE EEKHPVHLCK IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYPD
250 260 270 280 290 300
YEVEAYRRRH HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET
SGDSQLLS