P0CW00

PR
Gene name
TSPY8
Protein name
Testis-specific Y-encoded protein 8
Names
Species
Homo sapiens (Human)
KEGG Pathway
hsa:728403
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

58-166 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CW00

Entry ID Method Resolution Chain Position Source
AF-P0CW00-F1 Predicted AlphaFoldDB

46 variants for P0CW00

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1603140079
CA414787533
 2 R>C No ClinGen
Ensembl
rs760572223
CA10572407
 3 P>R No ClinGen
ExAC
gnomAD
rs753631588
CA10572409
 5 G>C No ClinGen
ExAC
gnomAD
CA10572410
rs758572301
 5 G>D No ClinGen
ExAC
rs757408537
CA10572413
 7 L>M No ClinGen
ExAC
rs780310523
CA414787650
CA10572417
 10 W>C No ClinGen
ExAC
gnomAD
CA10572418
rs749613655
 11 V>L No ClinGen
ExAC
gnomAD
CA10572419
rs1556180031
 13 E>G No ClinGen
Ensembl
CA10572421
rs768306591
 14 R>S No ClinGen
ExAC
gnomAD
rs1476646611
CA414787750
 18 G>C No ClinGen
gnomAD
rs747718289
CA10572423
 20 C>Y No ClinGen
ExAC
CA414787798
rs1172231287
 22 V>M No ClinGen
gnomAD
CA10572424
rs771553199
 23 G>S No ClinGen
ExAC
rs773243424
CA414787822
 24 R>W No ClinGen
ExAC
gnomAD
TCGA novel 39 A>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA414788157
rs1464787539
 48 G>R No ClinGen
gnomAD
rs1464787539
CA414788158
 48 G>W No ClinGen
gnomAD
TCGA novel 57 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA414788348
rs1603140150
 62 E>* No ClinGen
Ensembl
TCGA novel 77 V>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA414789284
rs1556180134
 131 S>T No ClinGen
Ensembl
CA414789477
rs1328941043
 144 H>Q No ClinGen
gnomAD
CA414789509
rs1556180155
 147 R>C No ClinGen
Ensembl
rs1432728779
CA414791239
 232 S>Y No ClinGen
gnomAD
rs1603140212
CA414791291
 235 I>S No ClinGen
Ensembl
rs1278931930
CA414791280
 235 I>V No ClinGen
gnomAD
CA10572426
rs760563458
 237 W>* No ClinGen
ExAC
gnomAD
CA414791348
rs760563458
 237 W>C No ClinGen
ExAC
gnomAD
rs1216872203
CA645293768
 238 Y>* No ClinGen
gnomAD
rs410975
CA337637650
 239 L>P No ClinGen
Ensembl
CA414791416
rs1603140251
 240 D>E No ClinGen
Ensembl
CA414791410
rs1603140245
 240 D>G No ClinGen
Ensembl
CA414791399
rs1603140240
 240 D>H No ClinGen
Ensembl
CA414791447
rs1603140259
 242 E>* No ClinGen
Ensembl
rs1238925689
CA414791508
 244 E>G No ClinGen
Ensembl
rs1603140269
CA414791553
 246 Y>* No ClinGen
Ensembl
CA10572427
rs770855086
 246 Y>D No ClinGen
ExAC
CA10572428
rs78649013
 247 R>C No ClinGen
ExAC
gnomAD
CA414791558
rs78649013
 247 R>S No ClinGen
ExAC
gnomAD
CA10572429
rs759309586
 248 R>H No ClinGen
ExAC
gnomAD
CA10572430
rs764478973
 259 N>H No ClinGen
ExAC
gnomAD
CA414791892
rs1477246214
 263 D>N No ClinGen
gnomAD
rs1556180322
CA414791995
 269 S>F No ClinGen
Ensembl
COSM4157084
rs368632690
CA10572431
 304 S>F thyroid [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
CA414792681
rs1603140324
 305 Q>H No ClinGen
Ensembl
CA414792738
rs1603140329
 309 S>S No ClinGen
Ensembl

No associated diseases with P0CW00

9 regional properties for P0CW00

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 422 - 645 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1211 - 1444 IPR003439-2
domain AAA+ ATPase domain 449 - 638 IPR003593-1
domain AAA+ ATPase domain 1237 - 1419 IPR003593-2
domain ABC transporter type 1, transmembrane domain 82 - 350 IPR011527-1
domain ABC transporter type 1, transmembrane domain 860 - 1158 IPR011527-2
conserved_site ABC transporter-like, conserved site 547 - 561 IPR017871
domain CFTR regulator domain 638 - 849 IPR025837
domain Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1 389 - 669 IPR047082

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
gonadal mesoderm development The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O19110 TSPY1 Testis-specific Y-encoded protein 1 Bos taurus (Bovine) PR
Q99457 NAP1L3 Nucleosome assembly protein 1-like 3 Homo sapiens (Human) PR
P55209 NAP1L1 Nucleosome assembly protein 1-like 1 Homo sapiens (Human) PR
Q01534 TSPY1 Testis-specific Y-encoded protein 1 Homo sapiens (Human) PR
P0CV99 TSPY4 Testis-specific Y-encoded protein 4 Homo sapiens (Human) PR
P0CV98 TSPY3 Testis-specific Y-encoded protein 3 Homo sapiens (Human) PR
P0CW01 TSPY10 Testis-specific Y-encoded protein 10 Homo sapiens (Human) PR
A6NKD2 TSPY2 Testis-specific Y-encoded protein 2 Homo sapiens (Human) PR
Q8N831 TSPYL6 Testis-specific Y-encoded-like protein 6 Homo sapiens (Human) PR
Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 Homo sapiens (Human) PR
P0DME0 SETSIP Protein SETSIP Homo sapiens (Human) SS
Q01105 SET Protein SET Homo sapiens (Human) SS
Q9H489 TSPY26P Putative testis-specific Y-encoded-like protein 3 Homo sapiens (Human) PR
Q9R1M3 Tspy1 Testis-specific Y-encoded protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MRPEGSLTYW VPERLRQGFC GVGRAAQALV CASAKEGTAF RMEAVQEGAA GVESEQAALG
70 80 90 100 110 120
EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP GPMTPESALE ELLAVQVELE
130 140 150 160 170 180
PVNAQARKAF SRQREKMERR RKPHLDRRGA VIQSVPGFWA NVIANHPQMS ALITDEDEDM
190 200 210 220 230 240
LSYMVSLEVE EEKHPVHLCK IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYLD
250 260 270 280 290 300
YEVEAYRRRH HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET
SGDSQLLS