P0CV99

PR
Gene name
TSPY4
Protein name
Testis-specific Y-encoded protein 4
Names
Species
Homo sapiens (Human)
KEGG Pathway
hsa:728395
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

59-173 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CV99

Entry ID Method Resolution Chain Position Source
AF-P0CV99-F1 Predicted AlphaFoldDB

18 variants for P0CV99

Variant ID(s) Position Change Description Diseaes Association Provenance
rs879057884
CA337637587
 10 R>W No ClinGen
Ensembl
CA414781682
rs1603139257
 52 V>A No ClinGen
Ensembl
CA414782147
rs1603139262
 74 V>E No ClinGen
Ensembl
rs1603139262
CA414782153
 74 V>G No ClinGen
Ensembl
CA414782268
rs1603139267
 80 V>G No ClinGen
Ensembl
CA414782307
rs1603139270
 82 V>G No ClinGen
Ensembl
CA414782527
rs1603139271
 94 E>G No ClinGen
Ensembl
rs1603139275
CA414782547
 95 E>G No ClinGen
Ensembl
rs1603139282
CA414782876
 113 S>A No ClinGen
Ensembl
CA414783351
rs1556179159
 137 S>T No ClinGen
Ensembl
CA414783409
rs1259762569
 140 R>W No ClinGen
Ensembl
rs1332765786
CA414783639
 150 H>Q No ClinGen
gnomAD
CA414783687
rs1199647885
 153 R>C No ClinGen
Ensembl
rs1257206373
CA414783804
 159 Q>P No ClinGen
Ensembl
CA414785745
rs1556179224
 243 W>* No ClinGen
Ensembl
rs1556179230
CA414785946
 253 R>C No ClinGen
Ensembl
rs1556179264
CA414787350
 310 S>F No ClinGen
Ensembl
CA414787358
rs1603139360
 311 Q>* No ClinGen
Ensembl

No associated diseases with P0CV99

No regional properties for P0CV99

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P0CV99

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
gonadal mesoderm development The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O19110 TSPY1 Testis-specific Y-encoded protein 1 Bos taurus (Bovine) PR
Q99457 NAP1L3 Nucleosome assembly protein 1-like 3 Homo sapiens (Human) PR
P55209 NAP1L1 Nucleosome assembly protein 1-like 1 Homo sapiens (Human) PR
Q01534 TSPY1 Testis-specific Y-encoded protein 1 Homo sapiens (Human) PR
P0CV98 TSPY3 Testis-specific Y-encoded protein 3 Homo sapiens (Human) PR
P0CW00 TSPY8 Testis-specific Y-encoded protein 8 Homo sapiens (Human) PR
P0CW01 TSPY10 Testis-specific Y-encoded protein 10 Homo sapiens (Human) PR
A6NKD2 TSPY2 Testis-specific Y-encoded protein 2 Homo sapiens (Human) PR
Q8N831 TSPYL6 Testis-specific Y-encoded-like protein 6 Homo sapiens (Human) PR
Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 Homo sapiens (Human) PR
P0DME0 SETSIP Protein SETSIP Homo sapiens (Human) SS
Q01105 SET Protein SET Homo sapiens (Human) SS
Q9H489 TSPY26P Putative testis-specific Y-encoded-like protein 3 Homo sapiens (Human) PR
Q9EQU5 Set Protein SET Mus musculus (Mouse) EV
Q9R1M3 Tspy1 Testis-specific Y-encoded protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MRPEGSLTYR VPERLRQGFC GVGRAAQALV CASAKEGTAF RMEAVQEGAA GVESEQAALG
70 80 90 100 110 120
EEAVLLLDDI MAEVEVVAEV EVVAEEEGLV ERREEAQRAQ QAVPGPGPMT PESALEELLA
130 140 150 160 170 180
VQVELEPVNA QARKAFSRQR EKMERRRKPH LDRRGAVIQS VPGFWANVIA NHPQMSALIT
190 200 210 220 230 240
DEDEDMLSYM VSLEVEEEKH PVHLCKIMLF FRSNPYFQNK VITKEYLVNI TEYRASHSTP
250 260 270 280 290 300
IEWYPDYEVE AYRRRHHNSS LNFFNWFSDH NFAGSNKIAE ILCKDLWRNP LQYYKRMKPP
310
EEGTETSGDS QLLS