P0CV98
PR
Gene name |
TSPY3 |
Protein name |
Testis-specific Y-encoded protein 3 |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:728137 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0CV98
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0CV98-F1 | Predicted | AlphaFoldDB |
32 variants for P0CV98
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1603141598 CA414794463 |
22 | V>L | No |
ClinGen Ensembl |
|
|
CA414794872 rs1603141603 |
52 | V>G | No |
ClinGen Ensembl |
|
|
rs1603141608 CA414794899 |
54 | S>R | No |
ClinGen Ensembl |
|
|
CA414795926 rs1556181266 |
131 | S>T | No |
ClinGen Ensembl |
|
|
rs1556181276 CA414796140 |
147 | R>C | No |
ClinGen Ensembl |
|
|
rs1603141654 CA414796679 |
184 | M>V | No |
ClinGen Ensembl |
|
|
CA414797083 rs1219141147 |
206 | R>W | No |
ClinGen Ensembl |
|
|
CA414797655 rs1379353911 |
228 | R>S | No |
ClinGen gnomAD |
|
|
rs755328003 CA10572440 |
235 | I>V | No |
ClinGen ExAC |
|
|
CA414797895 rs1603141715 |
239 | P>Q | No |
ClinGen Ensembl |
|
|
rs747771474 CA10572442 |
241 | Y>* | No |
ClinGen ExAC |
|
|
rs778589299 CA10572441 |
241 | Y>H | No |
ClinGen ExAC |
|
|
CA414798017 rs1352162650 |
244 | E>A | No |
ClinGen gnomAD |
|
|
CA10572443 rs771675793 |
245 | A>E | No |
ClinGen ExAC gnomAD |
|
|
CA414798029 rs1224356028 |
245 | A>T | No |
ClinGen gnomAD |
|
|
CA10572444 rs771675793 |
245 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA10572446 rs746471360 |
247 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs770780960 CA10572447 |
247 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA10572448 rs776627032 |
248 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA10572449 rs759462673 |
248 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs759462673 CA10572450 |
248 | R>P | No |
ClinGen ExAC gnomAD |
|
|
CA414798183 rs774753415 |
251 | H>L | No |
ClinGen ExAC gnomAD |
|
|
CA10572451 rs774753415 |
251 | H>R | No |
ClinGen ExAC gnomAD |
|
|
rs1179056320 CA414798170 |
251 | H>Y | No |
ClinGen gnomAD |
|
|
rs762155735 CA10572452 |
259 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA414798396 rs1166895573 |
260 | W>* | No |
ClinGen gnomAD |
|
|
CA10572453 rs767726541 |
260 | W>C | No |
ClinGen ExAC |
|
|
rs1368977900 CA414798445 |
262 | S>C | No |
ClinGen gnomAD |
|
|
CA10572454 rs773175478 |
263 | D>E | No |
ClinGen ExAC |
|
|
CA414798548 rs1457502683 |
267 | A>T | No |
ClinGen gnomAD |
|
|
rs1556181519 CA414798594 |
269 | S>F | No |
ClinGen Ensembl |
|
|
CA414799465 rs1556181563 |
304 | S>F | No |
ClinGen Ensembl |
No associated diseases with P0CV98
No regional properties for P0CV98
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P0CV98 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| gonadal mesoderm development | The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. |
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O19110 | TSPY1 | Testis-specific Y-encoded protein 1 | Bos taurus (Bovine) | PR |
| Q99457 | NAP1L3 | Nucleosome assembly protein 1-like 3 | Homo sapiens (Human) | PR |
| P55209 | NAP1L1 | Nucleosome assembly protein 1-like 1 | Homo sapiens (Human) | PR |
| Q01534 | TSPY1 | Testis-specific Y-encoded protein 1 | Homo sapiens (Human) | PR |
| P0CV99 | TSPY4 | Testis-specific Y-encoded protein 4 | Homo sapiens (Human) | PR |
| P0CW00 | TSPY8 | Testis-specific Y-encoded protein 8 | Homo sapiens (Human) | PR |
| P0CW01 | TSPY10 | Testis-specific Y-encoded protein 10 | Homo sapiens (Human) | PR |
| A6NKD2 | TSPY2 | Testis-specific Y-encoded protein 2 | Homo sapiens (Human) | PR |
| Q8N831 | TSPYL6 | Testis-specific Y-encoded-like protein 6 | Homo sapiens (Human) | PR |
| Q9H2G4 | TSPYL2 | Testis-specific Y-encoded-like protein 2 | Homo sapiens (Human) | PR |
| P0DME0 | SETSIP | Protein SETSIP | Homo sapiens (Human) | SS |
| Q01105 | SET | Protein SET | Homo sapiens (Human) | SS |
| Q9H489 | TSPY26P | Putative testis-specific Y-encoded-like protein 3 | Homo sapiens (Human) | PR |
| Q9EQU5 | Set | Protein SET | Mus musculus (Mouse) | EV |
| Q9R1M3 | Tspy1 | Testis-specific Y-encoded protein 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRPEGSLTYR | VPERLRQGFC | GVGRAAQALV | CASAKEGTAF | RMEAVQEGAA | GVESEQAALG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEAVLLLDDI | MAEVEVVAEE | EGLVERREEA | QRAQQAVPGP | GPMTPESALE | ELLAVQVELE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PVNAQARKAF | SRQREKMERR | RKPHLDRRGA | VIQSVPGFWA | NVIANHPQMS | ALITDEDEDM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSYMVSLEVE | EEKHPVHLCK | IMLFFRSNPY | FQNKVITKEY | LVNITEYRAS | HSTPIEWYPD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YEVEAYRRRH | HNSSLNFFNW | FSDHNFAGSN | KIAEILCKDL | WRNPLQYYKR | MKPPEEGTET |
| SGDSQLLS |