P0CB48

PR
Gene name
UBTFL6
Protein name
Putative upstream-binding factor 1-like protein 6
Names
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

39-400 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CB48

Entry ID Method Resolution Chain Position Source
AF-P0CB48-F1 Predicted AlphaFoldDB

No variants for P0CB48

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CB48

No associated diseases with P0CB48

9 regional properties for P0CB48

Type Name Position InterPro Accession
domain B-box-type zinc finger 88 - 129 IPR000315
domain Zinc finger, RING-type 15 - 56 IPR001841
domain B30.2/SPRY domain 269 - 446 IPR001870
domain SPRY domain 334 - 446 IPR003877
domain Butyrophylin-like, SPRY domain 319 - 343 IPR003879-1
domain Butyrophylin-like, SPRY domain 349 - 362 IPR003879-2
domain Butyrophylin-like, SPRY domain 394 - 418 IPR003879-3
domain Butyrophylin-like, SPRY domain 425 - 443 IPR003879-4
conserved_site Zinc finger, RING-type, conserved site 30 - 39 IPR017907

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
RNA polymerase I core promoter sequence-specific DNA binding Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.
RNA polymerase I general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs.

2 GO annotations of biological process

Name Definition
positive regulation of transcription by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
transcription by RNA polymerase I The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P17480 UBTF Nucleolar transcription factor 1 Homo sapiens (Human) EV
Q3USZ2 Ubtfl1 Upstream-binding factor 1-like protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MPAKDIKVAL PRSQGHWSNA DILRLLECME NNLPYDDNGT FSSTQSHMDW GKVAFKNFSG
70 80 90 100 110 120
EMCRLKWLEI SCSLRKFSTL KKLVLEAKKC VKNTNKSQKG RNHPDFPKRL LTAYIRFFKE
130 140 150 160 170 180
NWPQYSQMYP GMRSQEVTKI LSKKYKELPE QMKQKHIQDF RKEKQEFEEK LARFREEHPD
190 200 210 220 230 240
LDQKGKKSDI CKRVQTKVQK KVQKNIEEVR SLPKTDQFFK KVKFHGEPQK PPMNGYQKFH
250 260 270 280 290 300
QDSWSSKELQ HLSLRERMVE IGRRWQRIPQ SQKDHYKSQA ELLQKEYKVE LDLWLKTLSP
310 320 330 340 350 360
EDYAAYKEST YAKGKNMAMM GGPAPSLKQT DPQSSSAKGL QEGFGEGQGL QAAGTEASQT
370 380 390
IWVNCQVSME PEDNRKKDGE EEESSNSLDC SSGEDMEVDV