Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
669-918 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for P0C0K6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0C0K6-F1 | Predicted | AlphaFoldDB |
No variants for P0C0K6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0C0K6 | |||||
No associated diseases with P0C0K6
10 regional properties for P0C0K6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 669 - 918 | IPR000719 |
| domain | Ephrin receptor ligand binding domain | 33 - 236 | IPR001090 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 669 - 913 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 212 - 232 | IPR001426-1 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 285 - 305 | IPR001426-2 |
| domain | Sterile alpha motif domain | 944 - 1011 | IPR001660 |
| domain | Fibronectin type III | 368 - 485 | IPR003961-1 |
| domain | Fibronectin type III | 486 - 581 | IPR003961-2 |
| domain | Tyrosine-protein kinase ephrin type A/B receptor-like | 305 - 344 | IPR011641 |
| domain | Ephrin receptor, transmembrane domain | 595 - 666 | IPR027936 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
65 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C77 | At4g34220 | Receptor protein kinase-like protein At4g34220 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WR59 | At5g10020 | Probable inactive receptor kinase At5g10020 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGX1 | At5g65240 | Probable LRR receptor-like serine/threonine-protein kinase At5g65240 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXF2 | RKF1 | Probable LRR receptor-like serine/threonine-protein kinase RFK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGJ1 | At1g74360 | Probable LRR receptor-like serine/threonine-protein kinase At1g74360 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64556 | At2g19230 | Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGE4 | At1g12460 | Probable LRR receptor-like serine/threonine-protein kinase At1g12460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E991 | PRK6 | Pollen receptor-like kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATEGAAQLG | NRVAGMVCSL | WVLLLVSSVL | ALEEVLLDTT | GETSEIGWLT | YPPGGWDEVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLDDQRRLTR | TFEACHVAGA | PPGTGQDNWL | QTHFVERRGA | QRAHIRLHFS | VRACSSLGVS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GGTCRETFTL | YYRQAEEPDS | PDSVSSWHLK | RWTKVDTIAA | DESFPSSSSS | SSSSSAAWAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GPHGAGQRAG | LQLNVKERSF | GPLTQRGFYV | AFQDTGACLA | LVAVRLFSYT | CPAVLRSFAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FPETQASGAG | GASLVAAVGT | CVAHAEPEED | GVGGQAGGSP | PRLHCNGEGK | WMVAVGGCRC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QPGYQPARGD | KACQACPRGL | YKASAGNAPC | SPCPARSHAA | NPAAPVCPCL | EGFYRASSDP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEAPCTGPPS | APQELWFEVQ | GSALMLHWRL | PRELGGRGDL | LFNVVCKECE | GRQEPASGGG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GTCRRCRDEV | HFDPRQRGLT | ESRVLVGGLR | AHVPYILEVQ | AVNGVSELSP | DPPQAAAINV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| STSHEVPSAV | PVVHQVSRAS | NSITVSWPQP | DQTNGNILDY | QLRYYDQVED | ESHSFTLTSE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TNTATVTQLS | PGHIYGFQVR | ARTAAGHGPY | GGKVYFQTLP | QGELSSQLPE | RLSLVIGSIL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GALAFLLLAA | ITVLAVVFQR | KRRGTGYTEQ | LQQYSSPGLG | VKYYIDPSTY | EDPCQAIREL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AREVDPAYIK | IEEVIGTGSF | GEVRRGRLQP | RGRREQTVAI | QALWAGGAES | LQMTFLGRAA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VLGQFQHPNI | LRLEGVVTKS | RPLMVLTEFM | ELGPLDSFLR | QREGQFSSLQ | LVAMQRGVAA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AMQYLSSFAF | VHRSLSAHSV | LVNSHLVCKV | ARLGHSPQGP | SCLLRWAAPE | VIAHGKHTTS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SDVWSFGILM | WEVMSYGERP | YWDMSEQEVL | NAIEQEFRLP | PPPGCPPGLH | LLMLDTWQKD |
| 910 | 920 | 930 | 940 | 950 | 960 |
| RARRPHFDQL | VAAFDKMIRK | PDTLQACGDP | GERPSQALLT | PVALDFPCLD | SPQAWLSAIG |
| 970 | 980 | 990 | 1000 | 1010 | |
| LECYQDNFSK | FGLCTFSDVA | QLSLEDLPAL | GITLAGHQKK | LLHHIQLLQQ | HLRQQGSVEV |