P0A6A0

SS
Gene name
ubiB
Protein name
Probable protein kinase UbiB
Names
Ubiquinone biosynthesis protein UbiB
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b3835
EC number
Protein Class

Descriptions

UbiB is a protein kinase involved in coenzyme Q biosynthesis. Ubi1 may be autoinhibited by the intramolecular interaction between the KxGQ motif in N-termianl region and the binding site of the catalytic domain in the protein.

Autoinhibitory domains (AIDs)

70-73 (KxGQ motif) SS

Target domain

93-344 (ADCK3-like domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0A6A0

Entry ID Method Resolution Chain Position Source
AF-P0A6A0-F1 Predicted AlphaFoldDB

No variants for P0A6A0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0A6A0

No associated diseases with P0A6A0

2 regional properties for P0A6A0

Type Name Position InterPro Accession
domain ABC1 atypical kinase-like domain 93 - 344 IPR004147
domain UbiB domain, bacteria 93 - 344 IPR045308

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

2 GO annotations of biological process

Name Definition
regulation of ubiquinone biosynthetic process Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9MA15 ABC1K3 Protein ACTIVITY OF BC1 COMPLEX KINASE 3, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTPGEVRRLY FIIRTFLSYG LDELIPKMRI TLPLRLWRYS LFWMPNRHKD KLLGERLRLA
70 80 90 100 110 120
LQELGPVWIK FGQMLSTRRD LFPPHIADQL ALLQDKVAPF DGKLAKQQIE AAMGGLPVEA
130 140 150 160 170 180
WFDDFEIKPL ASASIAQVHT ARLKSNGKEV VIKVIRPDIL PVIKADLKLI YRLARWVPRL
190 200 210 220 230 240
LPDGRRLRPT EVVREYEKTL IDELNLLRES ANAIQLRRNF EDSPMLYIPE VYPDYCSEGM
250 260 270 280 290 300
MVMERIYGIP VSDVAALEKN GTNMKLLAER GVQVFFTQVF RDSFFHADMH PGNIFVSYEH
310 320 330 340 350 360
PENPKYIGID CGIVGSLNKE DKRYLAENFI AFFNRDYRKV AELHVDSGWV PPDTNVEEFE
370 380 390 400 410 420
FAIRTVCEPI FEKPLAEISF GHVLLNLFNT ARRFNMEVQP QLVLLQKTLL YVEGVGRQLY
430 440 450 460 470 480
PQLDLWKTAK PFLESWIKDQ VGIPALVRAF KEKAPFWVEK MPELPELVYD SLRQGKYLQH
490 500 510 520 530 540
SVDKIARELQ SNHVRQGQSR YFLGIGATLV LSGTFLLVSR PEWGLMPGWL MAGGLIAWFV
GWRKTR