AiPD: Autoinhibited Protein Database

P09769

Gene name	FGR (SRC2)
Protein name	Tyrosine-protein kinase Fgr
Names	FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, FGFR-2, K-sam, KGFR, Keratinocyte growth factor receptor, FGFR-3, FGFR-4, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Proto-oncogene c-Fgr, p55-Fgr, p58-Fgr, p58c-Fgr
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2268
EC number	2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

Tyrosine-protein kinase FGF plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. It is included in Src family nonreceptor tyrosine kinases. Src kinase family shares a conserved domain structure consisting of consecutive SH3, SH2, tyrosine kinase, and C-terminal tail. FGR may possess similar autoinhibitory mechanisms.

Autoinhibitory domains (AIDs)

77-138 (SH3 domain) SS

Target domain	263-516 (Protein kinase domain)
Relief mechanism	Partner binding
Assay

AID

77-138 (SH3 domain)

Target domain

263-516 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

142-241 (SH2 domain) SS

Target domain	263-516 (Protein kinase domain)
Relief mechanism	Partner binding
Assay

AID

142-241 (SH2 domain)

Target domain

263-516 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

242-262 (SH2-kinase domain linker) SS

Target domain	263-516 (Protein kinase domain)
Relief mechanism
Assay

AID

242-262 (SH2-kinase domain linker)

Target domain

263-516 (Protein kinase domain)

Relief mechanism

Assay

517-529 (C-terminal regulatory tail) SS

Target domain	263-516 (Protein kinase domain)
Relief mechanism	PTM
Assay

AID

517-529 (C-terminal regulatory tail)

Target domain

263-516 (Protein kinase domain)

Relief mechanism

PTM (Dephosphorylation of Tyr residue)

Assay

Accessory elements

No accessory elements

References

Boggon TJ et al. (2004) "Structure and regulation of Src family kinases", Oncogene, 23, 7918-27

Hong E et al. (2004) "Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain", The Journal of biological chemistry, 279, 29700-8

Ko S et al. (2009) "Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6", Biochemical and biophysical research communications, 384, 236-42

Qiu H et al. (2002) "Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition", The Journal of biological chemistry, 277, 34634-41

Williams JC et al. (1997) "The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions", Journal of molecular biology, 274, 757-75

Meng Y et al. (2014) "Locking the active conformation of c-Src kinase through the phosphorylation of the activation loop", Journal of molecular biology, 426, 423-35

Register AC et al. (2014) "SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family", Biochemistry, 53, 6910-23

Autoinhibited structure

Activated structure

4 structures for P09769

Entry ID	Method	Resolution	Chain	Position	Source
7JT9	X-ray	193 A	A	77-138	PDB
7UY0	X-ray	255 A	A/B	80-527	PDB
7UY3	X-ray	299 A	A	80-527	PDB
AF-P09769-F1	Predicted				AlphaFoldDB

326 variants for P09769

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA19894046 rs751282096	2	G>S		No	ClinGen gnomAD
CA19894040 rs77780281	9	L>W		No	ClinGen Ensembl
rs752716889 CA716633	11	P>L		No	ClinGen ExAC TOPMed gnomAD
CA716631 rs758535258	14	T>P		No	ClinGen ExAC gnomAD
CA339232182 rs1246773632	17	E>Q		No	ClinGen TOPMed
rs146161565 CA716628	18	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1462087141 CA339232146	19	A>V		No	ClinGen TOPMed
CA716627 rs776884502	20	G>V		No	ClinGen ExAC gnomAD
rs1257760064 CA339232111	22	E>D		No	ClinGen TOPMed
CA716626 rs555769133	23	G>E		No	ClinGen 1000Genomes ExAC gnomAD
CA339232109 rs1228339136	23	G>R		No	ClinGen gnomAD
CA19893972 rs555769133	23	G>V		No	ClinGen 1000Genomes ExAC gnomAD
CA339232040 rs1351464248	27	S>N		No	ClinGen gnomAD
rs891652600 CA339232025	28	Y>C		No	ClinGen TOPMed
rs1343617893 CA339232029	28	Y>H		No	ClinGen TOPMed
rs891652600 CA19893945	28	Y>S		No	ClinGen TOPMed
rs745374693 COSM1296253 CA716622	29	G>R	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs773958032 CA716621	30	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1296872415 CA339231961	33	H>Y		No	ClinGen TOPMed
rs1052489128 CA19893886	34	Y>C		No	ClinGen TOPMed gnomAD
CA339231949 rs1352065017	34	Y>H		No	ClinGen gnomAD
CA716620 rs770509406	36	P>S		No	ClinGen ExAC gnomAD
CA339231898 rs1297681498	37	D>E		No	ClinGen gnomAD
CA716619 rs749016269	38	P>R		No	ClinGen ExAC gnomAD
rs1557735748 CA339231887	39	T>P		No	ClinGen Ensembl
rs371790198 CA716616	42	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs371790198 CA716615	42	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA716617 rs756000945	42	R>W		No	ClinGen ExAC gnomAD
CA716614 rs754846513	43	P>L		No	ClinGen ExAC gnomAD
rs750537230 CA716613	44	A>V		No	ClinGen ExAC gnomAD
rs1248374546 CA339231810	45	S>F		No	ClinGen gnomAD
CA19893783 rs1039700474	48	A>S		No	ClinGen Ensembl
rs1450509321 CA339231723	52	N>S		No	ClinGen TOPMed gnomAD
CA716611 rs757264630	53	Y>H		No	ClinGen ExAC gnomAD
rs1431773797 CA339231699	54	S>G		No	ClinGen TOPMed
rs370434747 CA716610	54	S>N		No	ClinGen ESP ExAC gnomAD
CA19893773 rs942727362	55	N>K		No	ClinGen TOPMed gnomAD
rs764218601 CA716609	56	F>L		No	ClinGen ExAC gnomAD
CA339231659 rs1288130754	58	S>C		No	ClinGen gnomAD
rs910120741 CA19893763	60	A>T		No	ClinGen Ensembl
CA716608 rs761114087	60	A>V		No	ClinGen ExAC TOPMed gnomAD
CA716607 rs775929271	61	I>F		No	ClinGen ExAC gnomAD
rs1370596658 CA339231627	63	P>R		No	ClinGen TOPMed
rs1392397173 CA339231622	64	G>D		No	ClinGen TOPMed gnomAD
rs760070174 CA716604	67	D>Y		No	ClinGen ExAC gnomAD
rs770512024 CA716602	68	S>I		No	ClinGen ExAC gnomAD
CA716601 rs762361522	72	R>K		No	ClinGen ExAC gnomAD
CA716600 rs772979438	73	G>V		No	ClinGen ExAC gnomAD
rs1557735562 CA339231505	74	V>M		No	ClinGen Ensembl
CA716565 rs763333359	76	G>E		No	ClinGen ExAC gnomAD
rs1437774474 CA339231020	77	I>T		No	ClinGen gnomAD
CA716564 rs749974945	79	V>L		No	ClinGen ExAC TOPMed gnomAD
CA339231012 rs749974945	79	V>M		No	ClinGen ExAC TOPMed gnomAD
rs761281413 CA716562	81	L>M		No	ClinGen ExAC gnomAD
CA339230999 rs1226887373	81	L>P		No	ClinGen TOPMed
rs1272573454 CA339230996	82	F>L		No	ClinGen gnomAD
CA339230938 rs1557735093	90	A>P		No	ClinGen Ensembl
rs763724015 CA716560	91	R>Q		No	ClinGen ExAC gnomAD
CA339230916 rs760465857	93	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1007395671 CA19893051	94	D>N		No	ClinGen TOPMed gnomAD
rs766542896 CA19893049	97	T>S		No	ClinGen Ensembl
rs1283299814 CA339230874	100	K>E		No	ClinGen TOPMed
CA716557 rs772069319	101	G>D		No	ClinGen ExAC gnomAD
CA716555 rs376667196	102	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1390856692 CA339230862	102	E>K		No	ClinGen gnomAD
CA339230850 rs1459554976	103	K>M		No	ClinGen gnomAD
rs1048378161 CA19892985	103	K>N		No	ClinGen TOPMed gnomAD
CA339230849 rs1048378161	103	K>N		No	ClinGen TOPMed gnomAD
rs770062509 CA716554	105	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA716552 VAR_041700 rs34597831	110	T>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA716553 rs34597831	110	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA339230788 rs1281891352	111	E>A		No	ClinGen gnomAD
rs1571392991 CA339230745	116	E>D		No	ClinGen Ensembl
rs927827271 CA19891993	118	R>P		No	ClinGen TOPMed gnomAD
CA339230736 rs927827271	118	R>Q		No	ClinGen TOPMed gnomAD
rs774209795 RCV001263546 CA716537	118	R>W		No	ClinGen ClinVar ExAC dbSNP gnomAD
CA339230732 rs1571392960	119	S>A		No	ClinGen Ensembl
rs1293721916 CA339230719	121	S>N		No	ClinGen TOPMed
CA339230706 rs1270230493	123	G>E		No	ClinGen gnomAD
rs748240752 CA716535	123	G>R		No	ClinGen ExAC gnomAD
CA339230697 rs1429591241	124	K>N		No	ClinGen gnomAD
rs948830271 CA19891968	125	T>S		No	ClinGen TOPMed
rs1324257162 CA339230678	127	C>*		No	ClinGen gnomAD
CA339230684 rs1304900043	127	C>R		No	ClinGen Ensembl
rs376909607 CA716534	128	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_041701 CA716533 rs35334091	130	S>R		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
CA339230657 rs1375419336	131	N>H		No	ClinGen TOPMed gnomAD
CA716531 rs780292527	133	V>M		No	ClinGen ExAC gnomAD
CA716530 rs758756429	137	D>G		No	ClinGen ExAC gnomAD
CA716529 rs746232366	139	I>T		No	ClinGen ExAC gnomAD
rs902726074 CA19891908	141	A>G		No	ClinGen TOPMed
rs1557733735 CA339230584	142	E>*		No	ClinGen Ensembl
CA339230577 rs779407504	143	E>*		No	ClinGen ExAC TOPMed gnomAD
rs779407504 CA716528	143	E>K		No	ClinGen ExAC TOPMed gnomAD
rs771261181 CA716509	144	W>*		No	ClinGen ExAC gnomAD
CA19888432 rs959934596	149	I>M		No	ClinGen Ensembl
rs755633359 CA716506	149	I>T		No	ClinGen ExAC TOPMed gnomAD
CA19888401 rs867246914	150	G>E		No	ClinGen Ensembl
CA339228309 rs1435547867	151	R>K		No	ClinGen gnomAD
rs1034293860 CA19888399	153	D>N		No	ClinGen Ensembl
rs1233561855 CA339228242	154	A>V		No	ClinGen TOPMed gnomAD
CA716503 rs754615461	157	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1291837821 CA339228192	157	Q>L		No	ClinGen gnomAD
CA339228185 rs751425969	158	L>V		No	ClinGen ExAC TOPMed gnomAD
rs553405331 CA19888376	159	L>F		No	ClinGen Ensembl
CA716499 rs535305096	161	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762814220 CA716500	161	P>S		No	ClinGen ExAC gnomAD
CA716498 rs765208097	162	G>S		No	ClinGen ExAC gnomAD
CA19888362 rs968554929	163	N>K		No	ClinGen TOPMed
CA19888333 rs866819600	166	G>R		No	ClinGen Ensembl
rs775574356 CA716496	167	A>T		No	ClinGen ExAC gnomAD
CA716494 rs759801265	171	R>Q		No	ClinGen ExAC gnomAD
rs371101270 CA716492	172	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs774524869 CA716493	172	E>K		No	ClinGen ExAC
rs749636419 CA716491	173	S>I		No	ClinGen ExAC TOPMed gnomAD
rs769464544 CA716489	174	E>K		No	ClinGen ExAC TOPMed gnomAD
CA339227967 rs1213713059	176	T>I		No	ClinGen gnomAD
rs1467799748 CA339227962	177	K>E		No	ClinGen gnomAD
rs1299870297 CA339227842	184	I>L		No	ClinGen gnomAD
rs1361466036 CA339227827	185	R>Q		No	ClinGen TOPMed gnomAD
rs768352044 CA716469	185	R>W		No	ClinGen ExAC TOPMed gnomAD
rs746505513 CA716468	188	D>N		No	ClinGen ExAC TOPMed gnomAD
CA339227776 rs1432115988	189	Q>K		No	ClinGen TOPMed
rs1428380626 CA339227753	190	T>N		No	ClinGen gnomAD
CA716466 rs758058977	193	D>N		No	ClinGen ExAC gnomAD
CA716460 rs777849644	201	R>C		No	ClinGen ExAC TOPMed gnomAD
rs376766171 CA716459	201	R>H		No	ClinGen ESP ExAC gnomAD
rs1484940246 CA339227604	202	K>R		No	ClinGen TOPMed gnomAD
rs773286331 CA716456	205	M>I		No	ClinGen ExAC gnomAD
rs763110954 CA716457	205	M>K		No	ClinGen ExAC TOPMed gnomAD
rs763110954 CA339227564	205	M>T		No	ClinGen ExAC TOPMed gnomAD
CA339227570 rs1222866917	205	M>V		No	ClinGen TOPMed
rs1293663250 CA339227556	206	G>R		No	ClinGen gnomAD
rs762083500 CA716454 COSM907906	207	G>S	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs777257494 CA716453	209	Y>C		No	ClinGen ExAC gnomAD
CA716452 rs758448350	213	R>W		No	ClinGen ExAC gnomAD
CA716451 rs746522240	215	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs775100881 CA716450	216	F>S		No	ClinGen ExAC gnomAD
rs771875645 CA19887945	217	N>I		No	ClinGen ExAC TOPMed gnomAD
rs952303536 CA19887928	217	N>K		No	ClinGen TOPMed
rs771875645 CA716449	217	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1475959694 CA339227281	226	Y>H		No	ClinGen gnomAD
rs972434806 CA19887908	227	M>T		No	ClinGen TOPMed gnomAD
CA19887154 rs1003793936	229	V>A		No	ClinGen TOPMed
rs200015580 CA339227019	231	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2231878 CA716432	231	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA339226999 rs1557728297	232	G>V		No	ClinGen Ensembl
rs1371331124 CA339226927	236	L>M		No	ClinGen gnomAD
rs1324783399 CA339226907	237	L>F		No	ClinGen gnomAD
rs1459506091 CA339226893	237	L>R		No	ClinGen gnomAD
CA339226877 rs1453743304	238	I>T		No	ClinGen TOPMed gnomAD
CA339226837 rs1454746726	240	P>L		No	ClinGen gnomAD
rs1052772957 CA19887065	240	P>S		No	ClinGen TOPMed
rs1252398132 CA339226823	241	C>G		No	ClinGen gnomAD
CA339226806 rs1571381575	242	T>P		No	ClinGen Ensembl
rs1437330152 CA339226781	243	I>F		No	ClinGen TOPMed
rs542482063 CA716425	243	I>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1571381517 CA339226753	244	M>I		No	ClinGen Ensembl
rs769552626 CA716424	244	M>T		No	ClinGen ExAC TOPMed gnomAD
CA339226708 COSM907905 rs1205492492	246	P>L	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1283758241 CA339226703	247	Q>K		No	ClinGen gnomAD
rs1320461763 CA339226650	249	L>R		No	ClinGen TOPMed
CA339226642 rs1302018530	250	G>S		No	ClinGen TOPMed gnomAD
rs865786988 CA19887038	252	A>T		No	ClinGen Ensembl
CA716418 rs757382308	255	A>G		No	ClinGen ExAC gnomAD
CA339226492 rs1381975613	257	E>K		No	ClinGen gnomAD
rs1176103466 CA339226457	259	S>N		No	ClinGen gnomAD
rs1394560528 CA339226428	260	R>H		No	ClinGen gnomAD
rs754253842 CA716417	261	S>N		No	ClinGen ExAC gnomAD
rs1171205273 CA339226394	263	I>L		No	ClinGen TOPMed
rs1373856540 CA339226373	264	T>R		No	ClinGen TOPMed gnomAD
CA339226319 rs1260711632	268	R>Q		No	ClinGen gnomAD
rs753312344 CA716414	270	G>S		No	ClinGen ExAC gnomAD
CA716413 rs768078200	271	T>A		No	ClinGen ExAC gnomAD
rs888952996 CA19886960	276	D>G		No	ClinGen gnomAD
CA339226218 rs888952996	276	D>V		No	ClinGen gnomAD
CA339226198 rs1341083357	278	W>R		No	ClinGen gnomAD
rs1341083357 CA339226196	278	W>R		No	ClinGen gnomAD
CA339226076 rs1189357604	285	S>G		No	ClinGen gnomAD
CA339226061 rs1355225479	286	T>A		No	ClinGen gnomAD
CA339226053 rs1453937582	286	T>I		No	ClinGen TOPMed
rs148586227 CA339226044	287	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs148586227 CA716393	287	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA339226004 rs1571380810	290	V>G		No	ClinGen Ensembl
CA339226012 rs1396947832	290	V>M		No	ClinGen gnomAD
CA716392 rs149452269	295	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs970335559 CA339225940	296	G>R		No	ClinGen gnomAD
rs970335559 CA19886837	296	G>S		No	ClinGen gnomAD
CA339225928 rs1416829600	297	T>P		No	ClinGen gnomAD
CA716391 rs765844880	300	P>A		No	ClinGen ExAC gnomAD
rs1471081844 CA339225879	300	P>R		No	ClinGen gnomAD
CA339225814 rs1388939695	305	E>A		No	ClinGen TOPMed
rs1274633156 CA339225774	308	Q>P		No	ClinGen gnomAD
rs1571380586 CA339225752	309	V>G		No	ClinGen Ensembl
rs762522098 CA716390	309	V>I		No	ClinGen ExAC gnomAD
rs1446317344 CA339225746	310	M>V		No	ClinGen TOPMed
CA19886742 rs962155929	316	D>E		No	ClinGen TOPMed gnomAD
CA339225628 rs1571380520	319	V>G		No	ClinGen Ensembl
CA339225638 rs1288125206	319	V>M		No	ClinGen gnomAD
CA339225620 rs1571380510	320	Q>P		No	ClinGen Ensembl
CA716386 COSM295801 rs142690351	324	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC
CA339225538 rs1274938789	326	S>W		No	ClinGen TOPMed
CA716385 rs776370581	327	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1327246918 CA339225509	328	E>D		No	ClinGen Ensembl
CA339225466 rs1391223463	332	I>V		No	ClinGen Ensembl
CA339225454 rs901527530	333	V>L		No	ClinGen gnomAD
CA19886688 rs901527530	333	V>L		No	ClinGen gnomAD
CA339225455 rs901527530	333	V>M		No	ClinGen gnomAD
rs1349092643 CA339225428	335	E>D		No	ClinGen gnomAD
rs1018780685 CA19886682	339	H>Q		No	ClinGen Ensembl
CA716384 rs768661282	340	G>S		No	ClinGen ExAC gnomAD
rs1571379185 CA339224419	342	L>V		No	ClinGen Ensembl
rs1486409465 CA339224298	348	N>S		No	ClinGen gnomAD
rs1394276965 CA339224285	350	E>K		No	ClinGen TOPMed
rs1241847732 CA339224262	351	G>R		No	ClinGen gnomAD
rs1486906319 CA339224204	354	L>S		No	ClinGen gnomAD
CA339224134 rs1310705959	358	Q>R		No	ClinGen gnomAD
rs1362437486 CA339224081	360	V>M		No	ClinGen gnomAD
rs868013931 CA19886158	363	A>E		No	ClinGen gnomAD
rs1398090450 CA339223984	364	A>S		No	ClinGen gnomAD
rs752493866 CA716345	366	V>I		No	ClinGen ExAC gnomAD
rs907261374 CA19885891	369	G>S		No	ClinGen Ensembl
rs767580735 CA716344	372	Y>C		No	ClinGen ExAC gnomAD
rs759595392 CA716343	373	M>V		No	ClinGen ExAC gnomAD
CA339223788 rs774399386	374	E>D		No	ClinGen ExAC gnomAD
CA339223778 rs879373811	375	R>H		No	ClinGen gnomAD
rs879373811 CA19885860	375	R>L		No	ClinGen gnomAD
rs879373811 CA19885868	375	R>P		No	ClinGen gnomAD
CA716341 rs770064698	378	Y>C		No	ClinGen ExAC gnomAD
rs372083839 CA716339	381	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA19885838 rs756507665	381	R>H		No	ClinGen TOPMed
CA339223686 rs1571378110	382	D>A		No	ClinGen Ensembl
rs1308601532 CA339223608	388	I>V		No	ClinGen gnomAD
rs138858537 CA716336	391	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1328901950 CA339223563	392	E>K		No	ClinGen gnomAD
CA339223552 rs1463503186	392	E>V		No	ClinGen TOPMed
CA716332 rs779390995	393	R>Q		No	ClinGen ExAC gnomAD
rs746418519 CA716333	393	R>W		No	ClinGen ExAC gnomAD
CA716331 rs141214383	395	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA339223527 rs1200858737	395	A>T		No	ClinGen TOPMed
rs141214383 CA716330	395	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA716329 rs777318062	396	C>G		No	ClinGen ExAC
rs1439143818 CA339223428	402	G>D		No	ClinGen TOPMed gnomAD
rs1439143818 CA339223430	402	G>V		No	ClinGen TOPMed gnomAD
CA716328 rs755738879	404	A>V		No	ClinGen ExAC gnomAD
rs1469029358 CA339223401	405	R>C		No	ClinGen gnomAD
rs752268862 CA716327	405	R>H		No	ClinGen ExAC gnomAD
CA339223391 rs1370332766	406	L>F		No	ClinGen TOPMed
CA716326 rs767460030	407	I>M		No	ClinGen ExAC TOPMed gnomAD
rs759399215 CA716325	408	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1318291250 CA339223352	409	D>N		No	ClinGen TOPMed
CA339223307 rs751602520	411	E>D		No	ClinGen ExAC TOPMed gnomAD
rs751602520 CA339223308	411	E>D		No	ClinGen ExAC TOPMed gnomAD
CA339223320 rs1240721834	411	E>K		No	ClinGen gnomAD
rs1571377758 CA339223280	413	N>T		No	ClinGen Ensembl
CA716321 rs776733746	414	P>L		No	ClinGen ExAC gnomAD
rs761805327 CA716322	414	P>T		No	ClinGen ExAC
CA19885734 rs1041850783	415	C>W		No	ClinGen Ensembl
CA339223239 rs1385425342	416	Q>R		No	ClinGen TOPMed gnomAD
CA19884925 rs368600484	417	G>A		No	ClinGen ESP
CA339223007 rs1280973173	420	F>I		No	ClinGen TOPMed
CA339222985 rs1194101468	421	P>S		No	ClinGen gnomAD
CA339222960 rs1260900691	422	I>M		No	ClinGen gnomAD
CA19884921 rs945553067	426	A>T		No	ClinGen TOPMed
CA19884920 rs770749136	428	E>K		No	ClinGen Ensembl
rs759921948 CA716297	430	A>T		No	ClinGen ExAC gnomAD
CA339222800 rs1571375190	431	L>V		No	ClinGen Ensembl
CA339222707 rs1462953942	435	F>C		No	ClinGen TOPMed
rs1300861005 CA339222702	435	F>L		No	ClinGen gnomAD
rs755893994 CA19884884	440	D>E		No	ClinGen ExAC TOPMed gnomAD
CA716292 rs202144510	441	V>G		No	ClinGen ExAC TOPMed gnomAD
rs773586690 CA716293	441	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1408956056 CA339222571	442	W>*		No	ClinGen TOPMed
CA339222545 rs1449343830	443	S>C		No	ClinGen gnomAD
rs780998575 CA716290	444	F>S		No	ClinGen ExAC
rs1444183227 CA339222487	446	I>V		No	ClinGen TOPMed gnomAD
CA716288 rs746822700	451	L>F		No	ClinGen ExAC gnomAD
rs987403407 CA19884848	452	I>M		No	ClinGen TOPMed gnomAD
CA339222345 rs1200124502	453	T>S		No	ClinGen TOPMed
CA339222312 rs1557724584	455	G>D		No	ClinGen Ensembl
rs780043692 CA716287	456	R>*		No	ClinGen ExAC gnomAD
rs758102069 CA716286	456	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs765075016 CA716284	460	P>L		No	ClinGen ExAC TOPMed gnomAD
rs765075016 CA19884829	460	P>R		No	ClinGen ExAC TOPMed gnomAD
CA339221861 rs1369354908	462	M>T		No	ClinGen Ensembl
rs374251329 CA19884737	463	N>Y		No	ClinGen ESP TOPMed
rs895105804 CA19884732	465	R>W		No	ClinGen TOPMed gnomAD
rs779572041 CA716268	466	E>Q		No	ClinGen ExAC gnomAD
rs1456131761 CA339221687	472	E>G		No	ClinGen gnomAD
CA339221690 rs1345191474	472	E>K		No	ClinGen TOPMed
rs1456131761 CA339221685	472	E>V		No	ClinGen gnomAD
rs1222768368 CA339221656	474	G>D		No	ClinGen gnomAD
rs1046195142 CA19884698	477	M>I		No	ClinGen Ensembl
rs1363737705 CA339221594	478	P>L		No	ClinGen TOPMed
CA339221519 rs1278695094	483	C>S		No	ClinGen Ensembl
CA716260 rs144356569	489	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA19884639 rs768843133	495	W>*		No	ClinGen Ensembl
rs371312816 CA716258 COSM184504	496	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA716259 rs371312816	496	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141451773 COSM1341531 CA716257	496	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs371312816 CA19884618	496	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA339221328 rs762460007	498	D>E		No	ClinGen ExAC TOPMed gnomAD
CA339221326 rs762460007	498	D>E		No	ClinGen ExAC TOPMed gnomAD
CA716256 rs765797580	498	D>N		No	ClinGen ExAC gnomAD
CA339221314 rs1475319902	499	P>L		No	ClinGen TOPMed
rs777247084 CA716254	499	P>S		No	ClinGen ExAC gnomAD
CA19884581 rs201375566	501	E>G		No	ClinGen Ensembl
CA716252 rs200096273	503	P>A		No	ClinGen ExAC TOPMed
CA19884574 rs200096273	503	P>T		No	ClinGen ExAC TOPMed
CA339221225 rs1310198090	505	F>C		No	ClinGen gnomAD
rs1557724123 CA339221209	506	E>A		No	ClinGen Ensembl
CA339221180 rs1157515518	508	L>V		No	ClinGen gnomAD
CA716250 rs567317051	511	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745694834 CA716249	513	E>G		No	ClinGen ExAC TOPMed gnomAD
CA716248 rs374523467	515	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1571374246 CA339221091	517	T>P		No	ClinGen Ensembl
rs111872585 CA19884511	518	S>P		No	ClinGen Ensembl
CA19884526 rs111872585	518	S>T		No	ClinGen Ensembl
CA716246 rs371077484	519	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA339221034 rs1214498552	523	Y>C		No	ClinGen gnomAD
rs755064154 CA716244	524	Q>E		No	ClinGen ExAC gnomAD
rs143850913 CA716243 RCV001263547	525	P>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs758501487 CA716241	526	G>R		No	ClinGen ExAC TOPMed gnomAD
rs750638129 CA716240	527	D>A		No	ClinGen ExAC gnomAD
CA716239 rs765560511	528	Q>R		No	ClinGen ExAC gnomAD
rs139187589 CA716238	530	T>Y		No	ClinGen ESP ExAC

1 associated diseases with P09769

Without disease ID

8 regional properties for P09769

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	263 - 516	IPR000719
domain	SH2 domain	142 - 241	IPR000980
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	263 - 512	IPR001245
domain	SH3 domain	77 - 138	IPR001452
active_site	Tyrosine-protein kinase, active site	378 - 390	IPR008266
binding_site	Protein kinase, ATP binding site	269 - 291	IPR017441
domain	Tyrosine-protein kinase, catalytic domain	263 - 512	IPR020635
domain	Tyrosine-protein kinase Fgr, SH2 domain	140 - 240	IPR035693

Functions

		Description
EC Number	2.7.10.2	Protein-tyrosine kinases
Subcellular Localization	Cell membrane ; Lipid-anchor ; Cytoplasmic side Cell membrane; Peripheral membrane protein; Cytoplasmic side Cell projection, ruffle membrane Cytoplasm, cytosol Cytoplasm, cytoskeleton Mitochondrion inner membrane Mitochondrion intermembrane space	Detected in mitochondrial intermembrane space and at inner membranes (By similarity) Colocalizes with actin fibers at membrane ruffles Detected at plasma membrane lipid rafts
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
aggresome	An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extrinsic component of cytoplasmic side of plasma membrane	The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial intermembrane space	The region between the inner and outer lipid bilayers of the mitochondrial envelope.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ruffle membrane	The portion of the plasma membrane surrounding a ruffle.
secretory granule lumen	The volume enclosed by the membrane of a secretory granule.

9 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Fc-gamma receptor I complex binding	Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.
immunoglobulin receptor binding	Binding to one or more specific sites on an immunoglobulin receptor molecule.
non-membrane spanning protein tyrosine kinase activity	Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
phosphotyrosine residue binding	Binding to a phosphorylated tyrosine residue within a protein.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

24 GO annotations of biological process

Name	Definition
bone mineralization	The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
defense response to Gram-positive bacterium	Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
Fc-gamma receptor signaling pathway involved in phagocytosis	An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
immune response-regulating cell surface receptor signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
integrin-mediated signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
negative regulation of inflammatory response to antigenic stimulus	Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
negative regulation of natural killer cell activation	Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation.
peptidyl-tyrosine phosphorylation	The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cytokine production	Any process that activates or increases the frequency, rate or extent of production of a cytokine.
positive regulation of mast cell degranulation	Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
positive regulation of phosphatidylinositol 3-kinase activity	Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
positive regulation of phosphatidylinositol 3-kinase signaling	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of cell shape	Any process that modulates the surface configuration of a cell.
regulation of innate immune response	Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
regulation of phagocytosis	Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
regulation of protein kinase activity	Any process that modulates the frequency, rate or extent of protein kinase activity.
response to virus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
skeletal system morphogenesis	The process in which the anatomical structures of the skeleton are generated and organized.
transmembrane receptor protein tyrosine kinase signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

90 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A0JNB0	FYN	Tyrosine-protein kinase Fyn	Bos taurus (Bovine)	SS
Q0VBZ0	CSK	Tyrosine-protein kinase CSK	Bos taurus (Bovine)	SS
Q3ZC95	BTK	Tyrosine-protein kinase	Bos taurus (Bovine)	EV SS
P42683	LCK	Proto-oncogene tyrosine-protein kinase LCK	Gallus gallus (Chicken)	SS
P41239	CSK	Tyrosine-protein kinase CSK	Gallus gallus (Chicken)	SS
P00523	SRC	Proto-oncogene tyrosine-protein kinase Src	Gallus gallus (Chicken)	EV
Q8JH64	BTK	Tyrosine-protein kinase BTK	Gallus gallus (Chicken)	SS
P09324	YES1	Tyrosine-protein kinase Yes	Gallus gallus (Chicken)	SS
Q05876	FYN	Tyrosine-protein kinase Fyn	Gallus gallus (Chicken)	SS
Q75R65	JAK2	Tyrosine-protein kinase JAK2	Gallus gallus (Chicken)	SS
Q02977	YRK	Proto-oncogene tyrosine-protein kinase Yrk	Gallus gallus (Chicken)	SS
Q24592	hop	Tyrosine-protein kinase hopscotch	Drosophila melanogaster (Fruit fly)	PR
P08630	Btk	Tyrosine-protein kinase Btk	Drosophila melanogaster (Fruit fly)	SS
P00528	Src64B	Tyrosine-protein kinase Src64B	Drosophila melanogaster (Fruit fly)	SS
Q9V9J3	Src42A	Tyrosine-protein kinase Src42A	Drosophila melanogaster (Fruit fly)	SS
P23458	JAK1	Tyrosine-protein kinase JAK1	Homo sapiens (Human)	SS
O60674	JAK2	Tyrosine-protein kinase JAK2	Homo sapiens (Human)	EV
P52333	JAK3	Tyrosine-protein kinase JAK3	Homo sapiens (Human)	SS
P29597	TYK2	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (Human)	EV
P07947	YES1	Tyrosine-protein kinase Yes	Homo sapiens (Human)	SS
P41240	CSK	Tyrosine-protein kinase CSK	Homo sapiens (Human)	SS
P42680	TEC	Tyrosine-protein kinase Tec	Homo sapiens (Human)	SS
P51451	BLK	Tyrosine-protein kinase Blk	Homo sapiens (Human)	SS
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (Human)	SS
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Homo sapiens (Human)	EV
P43405	SYK	Tyrosine-protein kinase SYK	Homo sapiens (Human)	EV
P43403	ZAP70	Tyrosine-protein kinase ZAP-70	Homo sapiens (Human)	EV
Q13882	PTK6	Protein-tyrosine kinase 6	Homo sapiens (Human)	EV
P07948	LYN	Tyrosine-protein kinase Lyn	Homo sapiens (Human)	SS
P06241	FYN	Tyrosine-protein kinase Fyn	Homo sapiens (Human)	SS
P12931	SRC	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (Human)	EV
P06239	LCK	Tyrosine-protein kinase Lck	Homo sapiens (Human)	EV
P08631	HCK	Tyrosine-protein kinase HCK	Homo sapiens (Human)	EV
P42685	FRK	Tyrosine-protein kinase FRK	Homo sapiens (Human)	EV
Q06187	BTK	Tyrosine-protein kinase BTK	Homo sapiens (Human)	EV
P42679	MATK	Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (Human)	SS
Q14289	PTK2B	Protein-tyrosine kinase 2-beta	Homo sapiens (Human)	PR
Q05397	PTK2	Focal adhesion kinase 1	Homo sapiens (Human)	EV
Q13470	TNK1	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (Human)	PR
Q07912	TNK2	Activated CDC42 kinase 1	Homo sapiens (Human)	EV
P16591	FER	Tyrosine-protein kinase Fer	Homo sapiens (Human)	PR
Q6J9G0	STYK1	Tyrosine-protein kinase STYK1	Homo sapiens (Human)	PR
P42684	ABL2	Tyrosine-protein kinase ABL2	Homo sapiens (Human)	SS
P00519	ABL1	Tyrosine-protein kinase ABL1	Homo sapiens (Human)	EV
Q9R117	Tyk2	Non-receptor tyrosine-protein kinase TYK2	Mus musculus (Mouse)	SS
P08103	Hck	Tyrosine-protein kinase HCK	Mus musculus (Mouse)	SS
P16277	Blk	Tyrosine-protein kinase Blk	Mus musculus (Mouse)	SS
Q62270	Srms	Tyrosine-protein kinase Srms	Mus musculus (Mouse)	SS
Q64434	Ptk6	Protein-tyrosine kinase 6	Mus musculus (Mouse)	SS
P05480	Src	Proto-oncogene tyrosine-protein kinase Src	Mus musculus (Mouse)	EV
P35991	Btk	Tyrosine-protein kinase BTK	Mus musculus (Mouse)	EV
P41241	Csk	Tyrosine-protein kinase CSK	Mus musculus (Mouse)	EV
P25911	Lyn	Tyrosine-protein kinase Lyn	Mus musculus (Mouse)	EV
Q62137	Jak3	Tyrosine-protein kinase JAK3	Mus musculus (Mouse)	SS
Q62120	Jak2	Tyrosine-protein kinase JAK2	Mus musculus (Mouse)	EV
P06240	Lck	Proto-oncogene tyrosine-protein kinase LCK	Mus musculus (Mouse)	SS
P24604	Tec	Tyrosine-protein kinase Tec	Mus musculus (Mouse)	SS
Q04736	Yes1	Tyrosine-protein kinase Yes	Mus musculus (Mouse)	SS
P39688	Fyn	Tyrosine-protein kinase Fyn	Mus musculus (Mouse)	SS
P52332	Jak1	Tyrosine-protein kinase JAK1	Mus musculus (Mouse)	SS
Q03526	Itk	Tyrosine-protein kinase ITK/TSK	Mus musculus (Mouse)	SS
P41242	Matk	Megakaryocyte-associated tyrosine-protein kinase	Mus musculus (Mouse)	SS
Q922K9	Frk	Tyrosine-protein kinase FRK	Mus musculus (Mouse)	SS
P14234	Fgr	Tyrosine-protein kinase Fgr	Mus musculus (Mouse)	SS
A1Y2K1	FYN	Tyrosine-protein kinase Fyn	Sus scrofa (Pig)	SS
O19064	JAK2	Tyrosine-protein kinase JAK2	Sus scrofa (Pig)	SS
Q62662	Frk	Tyrosine-protein kinase FRK	Rattus norvegicus (Rat)	SS
Q62844	Fyn	Tyrosine-protein kinase Fyn	Rattus norvegicus (Rat)	SS
Q07014	Lyn	Tyrosine-protein kinase Lyn	Rattus norvegicus (Rat)	SS
P50545	Hck	Tyrosine-protein kinase HCK	Rattus norvegicus (Rat)	SS
Q9WUD9	Src	Proto-oncogene tyrosine-protein kinase Src	Rattus norvegicus (Rat)	SS
Q01621	Lck	Proto-oncogene tyrosine-protein kinase LCK	Rattus norvegicus (Rat)	SS
Q62689	Jak2	Tyrosine-protein kinase JAK2	Rattus norvegicus (Rat)	SS
Q63272	Jak3	Tyrosine-protein kinase JAK3	Rattus norvegicus (Rat)	SS
P32577	Csk	Tyrosine-protein kinase CSK	Rattus norvegicus (Rat)	SS
P41243	Matk	Megakaryocyte-associated tyrosine-protein kinase	Rattus norvegicus (Rat)	SS
F1LM93	Yes1	Tyrosine-protein kinase Yes	Rattus norvegicus (Rat)	SS
Q6P6U0	Fgr	Tyrosine-protein kinase Fgr	Rattus norvegicus (Rat)	SS
G5ECJ6	csk-1	Tyrosine-protein kinase csk-1	Caenorhabditis elegans	SS
O45539	src-2	Tyrosine protein-kinase src-2	Caenorhabditis elegans	SS
G5EE56	src-1	Tyrosine protein-kinase src-1	Caenorhabditis elegans	SS
Q2MHE4	HT1	Serine/threonine/tyrosine-protein kinase HT1	Arabidopsis thaliana (Mouse-ear cress)	PR
O22558	STY8	Serine/threonine-protein kinase STY8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8RWL6	STY17	Serine/threonine-protein kinase STY17	Arabidopsis thaliana (Mouse-ear cress)	PR
F4JTP5	STY46	Serine/threonine-protein kinase STY46	Arabidopsis thaliana (Mouse-ear cress)	PR
A1A5H8	yes1	Tyrosine-protein kinase yes	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
F1RDG9	fynb	Tyrosine-protein kinase fynb	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
O12990	jak1	Tyrosine-protein kinase JAK1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q1JPZ3	src	Proto-oncogene tyrosine-protein kinase Src	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q6EWH2	fyna	Tyrosine-protein kinase fyna	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MGCVFCKKLE	PVATAKEDAG	LEGDFRSYGA	ADHYGPDPTK	ARPASSFAHI	PNYSNFSSQA
70	80	90	100	110	120
INPGFLDSGT	IRGVSGIGVT	LFIALYDYEA	RTEDDLTFTK	GEKFHILNNT	EGDWWEARSL
130	140	150	160	170	180
SSGKTGCIPS	NYVAPVDSIQ	AEEWYFGKIG	RKDAERQLLS	PGNPQGAFLI	RESETTKGAY
190	200	210	220	230	240
SLSIRDWDQT	RGDHVKHYKI	RKLDMGGYYI	TTRVQFNSVQ	ELVQHYMEVN	DGLCNLLIAP
250	260	270	280	290	300
CTIMKPQTLG	LAKDAWEISR	SSITLERRLG	TGCFGDVWLG	TWNGSTKVAV	KTLKPGTMSP
310	320	330	340	350	360
KAFLEEAQVM	KLLRHDKLVQ	LYAVVSEEPI	YIVTEFMCHG	SLLDFLKNPE	GQDLRLPQLV
370	380	390	400	410	420
DMAAQVAEGM	AYMERMNYIH	RDLRAANILV	GERLACKIAD	FGLARLIKDD	EYNPCQGSKF
430	440	450	460	470	480
PIKWTAPEAA	LFGRFTIKSD	VWSFGILLTE	LITKGRIPYP	GMNKREVLEQ	VEQGYHMPCP
490	500	510	520
PGCPASLYEA	MEQTWRLDPE	ERPTFEYLQS	FLEDYFTSAE	PQYQPGDQT