Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

31 structures for P09661

Entry ID Method Resolution Chain Position Source
1A9N X-ray 238 A A/C 1-176 PDB
5MQF EM 590 A W 1-255 PDB
5O9Z EM 450 A z 1-255 PDB
5XJC EM 360 A o 1-255 PDB
5YZG EM 410 A o 1-255 PDB
5Z56 EM 510 A o 1-255 PDB
5Z57 EM 650 A o 1-255 PDB
5Z58 EM 490 A o 1-255 PDB
6AH0 EM 570 A o 1-255 PDB
6AHD EM 380 A o 1-255 PDB
6FF7 EM 450 A W 1-255 PDB
6ICZ EM 300 A o 1-255 PDB
6ID0 EM 290 A o 1-255 PDB
6ID1 EM 286 A o 1-255 PDB
6QDV EM 330 A W 2-162 PDB
6QX9 EM 328 A 2A 1-255 PDB
6Y53 EM 710 A a 1-255 PDB
6Y5Q EM 710 A a 1-255 PDB
7A5P EM 500 A W 1-255 PDB
7ABG EM 780 A W 1-255 PDB
7ABI EM 800 A W 1-255 PDB
7EVO EM 250 A F 1-255 PDB
7VPX EM 300 A F 1-255 PDB
7W59 EM 360 A o 1-255 PDB
7W5A EM 360 A o 1-255 PDB
7W5B EM 430 A o 1-255 PDB
8C6J EM 280 A W 1-255 PDB
8CH6 EM 590 A r 1-255 PDB
8HK1 EM 270 A F 1-255 PDB
8QO9 EM 529 A 2A 1-255 PDB
AF-P09661-F1 Predicted AlphaFoldDB

144 variants for P09661

Variant ID(s) Position Change Description Diseaes Association Provenance
TCGA novel 1 M>? Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA7763347
rs777988186
4 L>M No ClinGen
ExAC
TOPMed
gnomAD
rs1404929833
CA393967197
5 T>A No ClinGen
TOPMed
gnomAD
rs772555366
CA7763346
5 T>M No ClinGen
ExAC
TOPMed
gnomAD
CA393967167
rs1390475867
10 E>K No ClinGen
TOPMed
CA276343375
rs561721413
CA7763344
11 Q>H No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1040869856
CA276343370
13 A>V No ClinGen
TOPMed
gnomAD
CA7763343
rs755005074
14 Q>R No ClinGen
ExAC
gnomAD
rs1243664450
CA393967133
15 Y>H No ClinGen
TOPMed
rs1447146268
CA393967126
16 T>A No ClinGen
gnomAD
rs1314344421
CA393967118
17 N>S No ClinGen
TOPMed
CA7763342
rs753952520
20 R>H No ClinGen
ExAC
gnomAD
CA7763341
rs781038951
21 D>Y No ClinGen
ExAC
gnomAD
CA7763340
rs757152353
22 R>W No ClinGen
ExAC
TOPMed
gnomAD
CA393967072
rs1400924250
25 D>N Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA7763338
rs763788242
26 L>F No ClinGen
ExAC
gnomAD
rs754665870
CA7763314
28 G>E No ClinGen
ExAC
rs905473905
CA276343248
28 G>R No ClinGen
TOPMed
rs1226462085
CA393967034
29 Y>C No ClinGen
gnomAD
rs1272146544
CA393967037
29 Y>H No ClinGen
gnomAD
TCGA novel 30 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs138801817
CA7763311
32 P>S No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs755270186
CA276340915
33 V>I No ClinGen
TOPMed
gnomAD
CA393966990
rs1443545247
36 N>H No ClinGen
gnomAD
rs749503765
CA7763305
40 T>K No ClinGen
ExAC
gnomAD
rs749503765
CA7763306
40 T>M No ClinGen
ExAC
gnomAD
rs143051052
CA276340882
47 I>V No ClinGen
ESP
TOPMed
gnomAD
CA7763301
rs557125509
51 D>E No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1421616242
CA393966888
51 D>N No ClinGen
gnomAD
CA393966883
rs1404755444
51 D>V No ClinGen
TOPMed
gnomAD
rs138420806
CA7763300
53 E>D No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs947423040
CA276340853
58 D>N No ClinGen
TOPMed
rs1490445110
CA393966830
59 G>D No ClinGen
gnomAD
CA7763299
rs748156963
59 G>S No ClinGen
ExAC
gnomAD
TCGA novel 60 F>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 61 P>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA276340847
rs1053301275
63 L>S No ClinGen
TOPMed
gnomAD
CA7763298
rs778848364
64 R>K No ClinGen
ExAC
gnomAD
rs753518771
CA7763296
66 L>P No ClinGen
ExAC
gnomAD
rs1438341100
CA393966778
67 K>R No ClinGen
TOPMed
CA393966751
rs1157834138
71 V>A No ClinGen
gnomAD
CA393966741
rs1286980212
73 N>H No ClinGen
gnomAD
CA393966738
rs1409644499
73 N>S No ClinGen
gnomAD
TCGA novel 75 R>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA7763295
rs766082491
75 R>T No ClinGen
ExAC
gnomAD
rs755543547
CA7763294
76 I>L No ClinGen
ExAC
gnomAD
CA7763284
rs745867854
78 R>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs776784734
CA7763283
78 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs745867854
CA393980516
78 R>S No ClinGen
ExAC
gnomAD
TCGA novel 81 E>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 82 G>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA276391133
rs768641217
83 L>V No ClinGen
Ensembl
rs1271985821
CA393980451
88 P>S No ClinGen
TOPMed
rs1207067390
CA393980439
90 L>V No ClinGen
TOPMed
rs749129281
CA7763278
94 I>F No ClinGen
ExAC
gnomAD
rs1243754804
CA393980392
97 N>S No ClinGen
gnomAD
rs142731245
CA7763275
99 S>N No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs114919170
CA7763273
100 L>I No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs114919170
CA7763274
100 L>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs369821067
CA393980366
101 V>L No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA7763271
rs369821067
101 V>M Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
CA7763242
rs769605360
108 P>L No ClinGen
ExAC
gnomAD
CA7763243
rs775327517
108 P>S No ClinGen
ExAC
TOPMed
gnomAD
CA7763241
rs745669436
112 L>V No ClinGen
ExAC
TOPMed
gnomAD
CA7763240
rs577233883
114 S>L No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1244018389
CA393979883
118 L>V No ClinGen
gnomAD
TCGA novel 119 S>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA393979769
rs1305290777
122 R>G No ClinGen
gnomAD
rs772901598
CA7763219
124 P>A No ClinGen
ExAC
gnomAD
CA393979702
rs1276985340
125 V>A No ClinGen
gnomAD
CA7763217
rs747643637
125 V>I No ClinGen
ExAC
gnomAD
CA7763216
rs779411044
126 T>I No ClinGen
ExAC
rs755457351
CA7763215
127 N>S No ClinGen
ExAC
TOPMed
gnomAD
rs749866603
CA7763214
129 K>Q No ClinGen
ExAC
gnomAD
rs780565103
CA7763213
130 H>Q No ClinGen
ExAC
gnomAD
CA393979591
rs1479198702
130 H>R No ClinGen
gnomAD
rs1400280744
CA393979582
131 Y>D No ClinGen
TOPMed
gnomAD
CA393979511
rs1464999709
133 L>W No ClinGen
gnomAD
rs1255731640
CA393979466
135 V>A No ClinGen
TOPMed
rs756583632
CA7763212
136 I>T No ClinGen
ExAC
gnomAD
CA393979462
rs1249280480
136 I>V No ClinGen
gnomAD
CA393979420
rs1446316109
138 K>E No ClinGen
gnomAD
rs757317130
CA7763209
140 P>L No ClinGen
ExAC
gnomAD
rs767869756
CA7763210
140 P>S No ClinGen
ExAC
gnomAD
rs767869756
CA7763211
140 P>T No ClinGen
ExAC
gnomAD
CA393979347
rs1596470717
142 V>I No ClinGen
Ensembl
rs1233769122
CA393979336
143 R>G No ClinGen
gnomAD
TCGA novel 148 Q>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA276385869
rs908504284
151 K>Q No ClinGen
Ensembl
CA7763192
rs150710048
155 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
1000Genomes
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1316539546
CA393978396
158 A>S No ClinGen
Ensembl
rs1459858540
CA393978376
160 K>N No ClinGen
gnomAD
CA7763191
rs781405747
161 M>I No ClinGen
ExAC
gnomAD
rs1476596171
CA393978370
161 M>T No ClinGen
TOPMed
rs1166981227
CA393978350
164 G>S No ClinGen
TOPMed
TCGA novel 165 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA393978335
rs1166299700
166 R>W No ClinGen
gnomAD
CA393978291
rs1427468833
173 D>N No ClinGen
gnomAD
rs1413812521
CA393978279
174 I>T No ClinGen
gnomAD
CA276385184
rs967280716
175 A>T No ClinGen
TOPMed
CA393978262
rs1396580511
177 R>K No ClinGen
TOPMed
rs150109462
CA276385157
180 T>I No ClinGen
ESP
TOPMed
gnomAD
rs186863613
CA7763161
182 N>S No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1002602341
CA276384705
183 P>L No ClinGen
TOPMed
rs761721002
CA393978201
184 G>A No ClinGen
ExAC
gnomAD
CA7763160
rs761721002
184 G>D No ClinGen
ExAC
gnomAD
rs527750619
CA393978189
186 G>A No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs527750619
CA7763159
186 G>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs763834626
CA7763158
187 L>F No ClinGen
ExAC
gnomAD
CA276384698
rs866869396
188 P>S No ClinGen
gnomAD
rs531907281
CA7763157
COSM959677
189 T>A endometrium [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
CA7763153
rs142009828
195 G>A No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA393978131
rs142009828
195 G>E No ClinGen
ESP
ExAC
TOPMed
gnomAD
TCGA novel 196 P>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1426191744
CA393978129
196 P>T No ClinGen
gnomAD
CA7763150
COSM1708589
rs773240837
197 S>F skin [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
CA7763149
rs772297229
198 P>S Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
CA7763147
rs147560644
200 D>E No ClinGen
ESP
ExAC
TOPMed
gnomAD
TCGA novel 200 D>G Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA7763148
rs748428177
200 D>N No ClinGen
ExAC
gnomAD
CA393978100
rs1474091788
201 V>I No ClinGen
TOPMed
CA393978082
rs1418348854
203 A>V No ClinGen
TOPMed
CA7763123
rs780921357
208 I>V No ClinGen
ExAC
gnomAD
CA276383963
rs755978201
209 A>T No ClinGen
Ensembl
rs1231250957
CA393978016
211 A>V No ClinGen
TOPMed
rs1396477329
CA393977998
215 A>T No ClinGen
gnomAD
CA393977995
rs1381110043
215 A>V No ClinGen
gnomAD
CA393977977
rs1375110306
218 E>K No ClinGen
gnomAD
CA276383958
rs943781712
219 R>K No ClinGen
Ensembl
rs1463642202
CA393977951
222 G>R No ClinGen
gnomAD
TCGA novel 224 L>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA7763118
rs752376277
226 S>A No ClinGen
ExAC
TOPMed
gnomAD
rs1567124067
CA393977890
231 G>D No ClinGen
Ensembl
CA7763117
rs373922948
233 E>G No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1258736102
CA393977873
233 E>K No ClinGen
TOPMed
CA7763116
rs145302917
234 R>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
gnomAD
rs753401813
CA7763115
234 R>H No ClinGen
ExAC
TOPMed
gnomAD
rs1567122671
CA393977173
243 E>K No ClinGen
Ensembl
CA7763094
rs141391407
244 E>D No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs991548658
CA276380484
247 E>Q No ClinGen
TOPMed
gnomAD
rs762095184
CA7763093
249 D>G No ClinGen
ExAC
TOPMed
gnomAD
CA393977081
rs1413188935
250 T>K No ClinGen
gnomAD
CA7763092
rs751930111
252 T>I No ClinGen
ExAC
gnomAD
CA393977043
rs1473049355
254 G>R No ClinGen
Ensembl

No associated diseases with P09661

2 regional properties for P09661

Type Name Position InterPro Accession
repeat Leucine-rich repeat 89 - 110 IPR001611
domain U2A'/phosphoprotein 32 family A, C-terminal 128 - 146 IPR003603

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
small nuclear ribonucleoprotein complex A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs.
spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
U2 snRNP A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes.
U2-type catalytic step 2 spliceosome A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.
U2-type precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
U2 snRNA binding Binding to a U2 small nuclear RNA (U2 snRNA).

4 GO annotations of biological process

Name Definition
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
U2-type prespliceosome assembly The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P57784 Snrpa1 U2 small nuclear ribonucleoprotein A' Mus musculus (Mouse) PR
P43333 At1g09760 U2 small nuclear ribonucleoprotein A' Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVKLTAELIE QAAQYTNAVR DRELDLRGYK IPVIENLGAT LDQFDAIDFS DNEIRKLDGF
70 80 90 100 110 120
PLLRRLKTLL VNNNRICRIG EGLDQALPCL TELILTNNSL VELGDLDPLA SLKSLTYLSI
130 140 150 160 170 180
LRNPVTNKKH YRLYVIYKVP QVRVLDFQKV KLKERQEAEK MFKGKRGAQL AKDIARRSKT
190 200 210 220 230 240
FNPGAGLPTD KKKGGPSPGD VEAIKNAIAN ASTLAEVERL KGLLQSGQIP GRERRSGPTD
250
DGEEEMEEDT VTNGS