P09581
SS
Gene name |
Csf1r (Csfmr, Fms) |
Protein name |
Macrophage colony-stimulating factor 1 receptor |
Names |
CSF-1 receptor , CSF-1-R , CSF-1R , M-CSF-R , EC 2.7.10.1 , Proto-oncogene c-Fms , CD antigen CD115 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12978 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The c-Kit receptor protein-tyrosine kinase is tightly regulated in normal cells, whereas deregulated c-Kit kinase activity is implicated in the pathogenesis of human cancers. Crystal structures of c-Kit kinase reveal a manner in which the small juxtamembrane domain functions to maintain the kinase in an autoinhibited state. Insertion of this autoinhibitory domain into the cleft between the kinase N- and C-lobes flips the DFG motif into its off state, thereby inducing the activation loop to fold back over from its extended conformation in the active kinase where it binds as a pseudosubstrate at the kinase-active center.
Autoinhibitory domains (AIDs)
Target domain |
580-922 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
793-818 (Activation loop from InterPro)
Target domain |
580-914 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
793-818 (Activation loop from InterPro)
Target domain |
580-914 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Hubbard SR (2004) "Juxtamembrane autoinhibition in receptor tyrosine kinases", Nature reviews. Molecular cell biology, 5, 464-71
- Mol CD et al. (2004) "Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase", The Journal of biological chemistry, 279, 31655-63
- Liang L et al. (2016) "Structural and biochemical studies of the PDGFRA kinase domain", Biochemical and biophysical research communications, 477, 667-672
Autoinhibited structure
Activated structure
3 structures for P09581
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3EJJ | X-ray | 240 A | X | 20-296 | PDB |
| 4EXP | X-ray | 280 A | X | 20-298 | PDB |
| AF-P09581-F1 | Predicted | AlphaFoldDB |
80 variants for P09581
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389510244 | 32 | V>I | No | EVA | |
| rs3389505809 | 66 | G>V | No | EVA | |
| rs3389471802 | 67 | S>N | No | EVA | |
| rs214881658 | 68 | T>I | No | EVA | |
| rs3389471757 | 79 | T>I | No | EVA | |
| rs3389504790 | 107 | S>Y | No | EVA | |
| rs3389498735 | 112 | A>V | No | EVA | |
| rs3389498697 | 125 | L>P | No | EVA | |
| rs3389498733 | 144 | G>E | No | EVA | |
| rs227420827 | 144 | G>R | No | EVA | |
| rs3389513735 | 161 | G>A | No | EVA | |
| rs3408455070 | 161 | G>E | No | EVA | |
| rs253634222 | 170 | L>I | No | EVA | |
| rs3389510256 | 178 | K>R | No | EVA | |
| rs3389521279 | 187 | T>S | No | EVA | |
| rs221093765 | 192 | W>R | No | EVA | |
| rs219399085 | 199 | H>P | No | EVA | |
| rs235850375 | 204 | Q>H | No | EVA | |
| rs3389471838 | 223 | V>L | No | EVA | |
| rs221668085 | 230 | E>K | No | EVA | |
| rs3389484085 | 232 | G>R | No | EVA | |
| rs247558055 | 252 | F>Y | No | EVA | |
| rs37050895 | 262 | A>V | No | EVA | |
| rs36759468 | 267 | A>S | No | EVA | |
| rs3389504806 | 301 | L>V | No | EVA | |
| rs3389471785 | 306 | E>* | No | EVA | |
| rs36364886 | 331 | I>L | No | EVA | |
| rs3389415778 | 335 | N>K | No | EVA | |
| rs3389510292 | 336 | W>* | No | EVA | |
| rs37248747 | 347 | R>H | No | EVA | |
| rs212067119 | 354 | Q>R | No | EVA | |
| rs240044929 | 355 | R>K | No | EVA | |
| rs3389499231 | 369 | V>A | No | EVA | |
| rs3410685160 | 374 | A>T | No | EVA | |
| rs252789025 | 378 | F>S | No | EVA | |
| rs3389505851 | 386 | G>D | No | EVA | |
| rs3389504796 | 388 | N>K | No | EVA | |
| rs3389499356 | 397 | R>L | No | EVA | |
| rs3389499311 | 399 | P>S | No | EVA | |
| rs3389521293 | 401 | E>V | No | EVA | |
| rs36842668 | 408 | P>A | No | EVA | |
| rs37080047 | 408 | P>H | No | EVA | |
| rs3389453790 | 433 | R>W | No | EVA | |
| rs3389500546 | 457 | S>T | No | EVA | |
| rs251943055 | 463 | K>R | No | EVA | |
| rs3389504723 | 468 | S>R | No | EVA | |
| rs3389484158 | 470 | L>M | No | EVA | |
| rs3389517920 | 485 | T>I | No | EVA | |
| rs3389517979 | 498 | A>T | No | EVA | |
| rs3389499352 | 510 | E>K | No | EVA | |
| rs3389415743 | 528 | V>M | No | EVA | |
| rs3389484117 | 537 | K>E | No | EVA | |
| rs29722587 | 553 | R>S | No | EVA | |
| rs3389505837 | 612 | A>T | No | EVA | |
| rs3389484087 | 662 | E>* | No | EVA | |
| rs3408617755 | 685 | L>R | No | EVA | |
| rs3408644384 | 688 | G>D | No | EVA | |
| rs3408535350 | 693 | G>A | No | EVA | |
| rs3408455127 | 699 | N>H | No | EVA | |
| rs3408542553 | 702 | L>* | No | EVA | |
| rs3389504805 | 719 | D>N | No | EVA | |
| rs3389471833 | 728 | S>* | No | EVA | |
| rs3389506379 | 744 | A>T | No | EVA | |
| rs3389513729 | 778 | A>T | No | EVA | |
| rs3389505816 | 810 | K>E | No | EVA | |
| rs3389510275 | 843 | L>P | No | EVA | |
| rs36964862 | 845 | E>D | No | EVA | |
| rs37883490 | 848 | S>W | No | EVA | |
| rs3389463081 | 859 | V>E | No | EVA | |
| rs3389500540 | 886 | I>N | No | EVA | |
| rs222713371 | 897 | R>K | No | EVA | |
| rs257881286 | 910 | E>K | No | EVA | |
| rs3389471786 | 920 | D>V | No | EVA | |
| rs3389521283 | 928 | G>R | No | EVA | |
| rs219116838 | 930 | S>C | No | EVA | |
| rs3389499327 | 940 | S>R | No | EVA | |
| rs3389521264 | 950 | E>K | No | EVA | |
| rs3389504792 | 955 | H>N | No | EVA | |
| rs3389463091 | 955 | H>Q | No | EVA | |
| rs3389500542 | 966 | Q>R | No | EVA |
No associated diseases with P09581
18 regional properties for P09581
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 580 - 914 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 580 - 905 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class III, conserved site | 639 - 652 | IPR001824 |
| domain | Immunoglobulin subtype 2 | 33 - 91 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 215 - 285 | IPR003598-2 |
| domain | Immunoglobulin subtype | 27 - 102 | IPR003599-1 |
| domain | Immunoglobulin subtype | 112 - 196 | IPR003599-2 |
| domain | Immunoglobulin subtype | 209 - 296 | IPR003599-3 |
| domain | Immunoglobulin subtype | 308 - 397 | IPR003599-4 |
| domain | Immunoglobulin subtype | 402 - 504 | IPR003599-5 |
| domain | Immunoglobulin-like domain | 21 - 85 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 104 - 188 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 203 - 294 | IPR007110-3 |
| domain | Immunoglobulin-like domain | 400 - 500 | IPR007110-4 |
| active_site | Tyrosine-protein kinase, active site | 772 - 784 | IPR008266 |
| domain | Immunoglobulin-like beta-sandwich domain | 214 - 290 | IPR013151 |
| binding_site | Protein kinase, ATP binding site | 586 - 614 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 580 - 908 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell body | The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| CSF1-CSF1R complex | A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cytokine binding | Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. |
| growth factor binding | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| macrophage colony-stimulating factor receptor activity | Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
| organic cyclic compound binding | Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein phosphatase binding | Binding to a protein phosphatase. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
51 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| cell-cell junction maintenance | The maintenance of junctions between cells. |
| cellular response to cytokine stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. |
| cellular response to macrophage colony-stimulating factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. |
| dentate gyrus development | The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. |
| forebrain neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| macrophage colony-stimulating factor signaling pathway | The series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| microglia development | The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
| microglial cell activation | The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. |
| microglial cell proliferation | The expansion of a microglial cell population by cell division. |
| monocyte homeostasis | The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| negative regulation of epithelial cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. |
| negative regulation of myotube differentiation | Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. |
| negative regulation of platelet formation | Any process that stops, prevents or reduces the frequency, rate or extent of platelet formation. |
| neuron projection extension | Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| neutrophil homeostasis | The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. |
| olfactory bulb development | The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex. |
| osteoclast differentiation | The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. |
| peptidyl-tyrosine phosphorylation | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
| positive regulation by host of viral process | A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. |
| positive regulation of astrocyte activation | Any process that increases the frequency, rate or extent of astrocyte activation. |
| positive regulation of bone mineralization | Any process that activates or increases the frequency, rate or extent of bone mineralization. |
| positive regulation of cell cycle G1/S phase transition | Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of chemokine production | Any process that activates or increases the frequency, rate, or extent of chemokine production. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of leukocyte proliferation | Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. |
| positive regulation of lymphocyte proliferation | Any process that activates or increases the rate or extent of lymphocyte proliferation. |
| positive regulation of macrophage chemotaxis | Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. |
| positive regulation of macrophage migration | Any process that activates or increases the frequency, rate or extent of macrophage migration. |
| positive regulation of macrophage proliferation | Any process that activates or increases the frequency, rate or extent of macrophage proliferation. |
| positive regulation of myoblast proliferation | Any process that activates or increases the frequency, rate or extent of myoblast proliferation. |
| positive regulation of osteoclast differentiation | Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| positive regulation of tumor necrosis factor production | Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. |
| positive regulation of tyrosine phosphorylation of STAT protein | Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of actin cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| regulation of bone resorption | Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| regulation of macrophage migration | Any process that modulates the frequency, rate or extent of macrophage migration. |
| regulation of MAPK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. |
| regulation of mononuclear cell proliferation | Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. |
| response to ischemia | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. |
| ruffle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
113 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| P18460 | FGFR3 | Fibroblast growth factor receptor 3 | Gallus gallus (Chicken) | SS |
| P21804 | FGFR1 | Fibroblast growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| Q9PUF6 | PDGFRA | Platelet-derived growth factor receptor alpha | Gallus gallus (Chicken) | SS |
| Q08156 | KIT | Mast/stem cell growth factor receptor Kit | Gallus gallus (Chicken) | SS |
| Q8QHL3 | FLT1 | Vascular endothelial growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| P18461 | FGFR2 | Fibroblast growth factor receptor 2 | Gallus gallus (Chicken) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P36888 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (Human) | EV |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens (Human) | EV |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens (Human) | EV |
| P35916 | FLT4 | Vascular endothelial growth factor receptor 3 | Homo sapiens (Human) | SS |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens (Human) | EV |
| P17948 | FLT1 | Vascular endothelial growth factor receptor 1 | Homo sapiens (Human) | SS |
| P10721 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens (Human) | EV |
| P22455 | FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens (Human) | SS |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| P07949 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (Human) | EV |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P11362 | FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens (Human) | EV |
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens (Human) | EV |
| P07333 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens (Human) | SS |
| Q91V87 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Mus musculus (Mouse) | PR |
| Q6J9G1 | Styk1 | Tyrosine-protein kinase STYK1 | Mus musculus (Mouse) | PR |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q2HWD6 | KIT | Mast/stem cell growth factor receptor Kit | Sus scrofa (Pig) | SS |
| Q7TQM3 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Rattus norvegicus (Rat) | PR |
| P53767 | Flt1 | Vascular endothelial growth factor receptor 1 | Rattus norvegicus (Rat) | PR |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| Q00495 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Rattus norvegicus (Rat) | PR |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| O64556 | At2g19230 | Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6XAT2 | ERL2 | LRR receptor-like serine/threonine-protein kinase ERL2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E991 | PRK6 | Pollen receptor-like kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C77 | At4g34220 | Receptor protein kinase-like protein At4g34220 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGJ1 | At1g74360 | Probable LRR receptor-like serine/threonine-protein kinase At1g74360 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGQ4 | MDIS2 | Protein MALE DISCOVERER 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFG1 | At3g53590 | Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WR59 | At5g10020 | Probable inactive receptor kinase At5g10020 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGX1 | At5g65240 | Probable LRR receptor-like serine/threonine-protein kinase At5g65240 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXF2 | RKF1 | Probable LRR receptor-like serine/threonine-protein kinase RFK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8AXB3 | kdrl | Vascular endothelial growth factor receptor kdr-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELGPPLVLL | LATVWHGQGA | PVIEPSGPEL | VVEPGETVTL | RCVSNGSVEW | DGPISPYWTL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DPESPGSTLT | TRNATFKNTG | TYRCTELEDP | MAGSTTIHLY | VKDPAHSWNL | LAQEVTVVEG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QEAVLPCLIT | DPALKDSVSL | MREGGRQVLR | KTVYFFSPWR | GFIIRKAKVL | DSNTYVCKTM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VNGRESTSTG | IWLKVNRVHP | EPPQIKLEPS | KLVRIRGEAA | QIVCSATNAE | VGFNVILKRG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DTKLEIPLNS | DFQDNYYKKV | RALSLNAVDF | QDAGIYSCVA | SNDVGTRTAT | MNFQVVESAY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LNLTSEQSLL | QEVSVGDSLI | LTVHADAYPS | IQHYNWTYLG | PFFEDQRKLE | FITQRAIYRY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TFKLFLNRVK | ASEAGQYFLM | AQNKAGWNNL | TFELTLRYPP | EVSVTWMPVN | GSDVLFCDVS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GYPQPSVTWM | ECRGHTDRCD | EAQALQVWND | THPEVLSQKP | FDKVIIQSQL | PIGTLKHNMT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YFCKTHNSVG | NSSQYFRAVS | LGQSKQLPDE | SLFTPVVVAC | MSVMSLLVLL | LLLLLYKYKQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KPKYQVRWKI | IERYEGNSYT | FIDPTQLPYN | EKWEFPRNNL | QFGKTLGAGA | FGKVVEATAF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GLGKEDAVLK | VAVKMLKSTA | HADEKEALMS | ELKIMSHLGQ | HENIVNLLGA | CTHGGPVLVI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TEYCCYGDLL | NFLRRKAEAM | LGPSLSPGQD | SEGDSSYKNI | HLEKKYVRRD | SGFSSQGVDT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YVEMRPVSTS | SSDSFFKQDL | DKEASRPLEL | WDLLHFSSQV | AQGMAFLASK | NCIHRDVAAR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NVLLTSGHVA | KIGDFGLARD | IMNDSNYVVK | GNARLPVKWM | APESIFDCVY | TVQSDVWSYG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ILLWEIFSLG | LNPYPGILVN | NKFYKLVKDG | YQMAQPVFAP | KNIYSIMQSC | WDLEPTRRPT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| FQQICFLLQE | QARLERRDQD | YANLPSSGGS | SGSDSGGGSS | GGSSSEPEEE | SSSEHLACCE |
| 970 | |||||
| PGDIAQPLLQ | PNNYQFC |