P09208
SS
Gene name |
InR (Dir-a, Inr-a, IR, CG18402) |
Protein name |
Insulin-like receptor |
Names |
dIR , dInr , EC 2.7.10.1 , Insulin receptor homolog , dIRH , Receptor protein-tyrosine kinase InR [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1 , Insulin-like receptor subunit beta 170 kDa form , beta170; Insulin-like receptor subunit beta 2 , Insulin-like receptor subunit beta 90 kDa form , beta90; 60 kDa C-terminal fragment , Insulin-like receptor free C-terminus] |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG18402 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Insulin signaling controls metabolic homeostasis. Insulin receptor (IR) is a receptor tyrosine kinase (RTK) that plays essential roles in glucose metabolism and cell growth and comprises two copies of extracellular α- and β-subunits. The α-subunit and the N-terminal part of the β-subunit are on the extracellular side, and the β-subunit continues with a single transmembrane helix and C-terminal cytoplasmic domains that are targets of insulin-dependent phosphorylation in downstream signaling. The α-subunits are disulphide linked to each other and to their respective β-subunit, and they form a large ectodomain comprising several subdomains (L1, CR, L2, FnIII (1-3)). IR has two distinct insulin-binding sites with different affinities for insulin, termed sites 1 and 2. One insulin molecule binds to the primary site, which consists of the L1 domain of one IR protomer and the C-terminal helix of the α chain (α-CT) of the other, site 1. The second insulin molecule is bound to the FnIII-1 domain, site 2. The ectodomain of the active IR/IR dimer adopts asymmetric conformations under non-saturating insulin concentrations in the dynamic range of 1-3 insulins bound. In first, site 2 acts as the initial insulin recruitment site, enabling insulin binding to site 1 at lower concentrations of insulin. In the next step, occupancy of a single site 1 in the two-protomer receptor is sufficient to induce assembly of the TM domains, and ultimately the cytoplasmic kinase domains, which eventually rearrange the IR/IR dimer into an active conformation. On the other hand, the fully saturated insulin receptor adopts symmetric conformation with 4 insulins bound, showing the difference in the conformation of the semi-saturated IR.
Autoinhibitory domains (AIDs)
Target domain |
1371-1659 (FnIII-2 domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
- Hubbard SR (2004) "Juxtamembrane autoinhibition in receptor tyrosine kinases", Nature reviews. Molecular cell biology, 5, 464-71
- Uchikawa E et al. (2019) "Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex", eLife, 8,
- Nielsen J et al. (2022) "Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling", Journal of molecular biology, 434, 167458
- Chen YS et al. (2021) "Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation", Proceedings of the National Academy of Sciences of the United States of America, 118,
- Craddock BP et al. (2007) "Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region", FEBS letters, 581, 3235-40
- Hubbard SR et al. (1994) "Crystal structure of the tyrosine kinase domain of the human insulin receptor", Nature, 372, 746-54
- Huang X et al. (2009) "Structural insights into the inhibited states of the Mer receptor tyrosine kinase", Journal of structural biology, 165, 88-96
Autoinhibited structure
Activated structure
2 structures for P09208
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8CLS | EM | 400 A | A/B | 264-1310 | PDB |
| AF-P09208-F1 | Predicted | AlphaFoldDB |
No variants for P09208
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P09208 | |||||
No associated diseases with P09208
13 regional properties for P09208
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Receptor L-domain | 356 - 463 | IPR000494-1 |
| domain | Receptor L-domain | 663 - 777 | IPR000494-2 |
| domain | Protein kinase domain | 1371 - 1659 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 1375 - 1649 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class II, conserved site | 1543 - 1551 | IPR002011 |
| domain | Fibronectin type III | 805 - 910 | IPR003961-1 |
| domain | Fibronectin type III | 929 - 1175 | IPR003961-2 |
| domain | Fibronectin type III | 1208 - 1305 | IPR003961-3 |
| domain | Furin-like cysteine-rich domain | 510 - 648 | IPR006211 |
| repeat | Furin-like repeat | 542 - 592 | IPR006212 |
| active_site | Tyrosine-protein kinase, active site | 1515 - 1527 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 1377 - 1405 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 1371 - 1650 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| growth cone membrane | The portion of the plasma membrane surrounding a growth cone. |
| insulin receptor complex | A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| identical protein binding | Binding to an identical protein or proteins. |
| insulin binding | Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| insulin receptor activity | Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| insulin receptor substrate binding | Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. |
| metal ion binding | Binding to a metal ion. |
| phosphatidylinositol 3-kinase binding | Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
56 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| carbohydrate homeostasis | A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. |
| cellular response to starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. |
| cholesterol homeostasis | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. |
| circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
| determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| developmental growth | The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. |
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| embryonic development via the syncytial blastoderm | The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. |
| female germ-line stem cell asymmetric division | The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. |
| female germ-line stem cell population maintenance | The process by which an organism or tissue maintains a population of female germ-line stem cells. |
| female gonad development | The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. |
| female mating behavior | The specific behavior of a female organism that is associated with reproduction. |
| follicle cell of egg chamber development | The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster. |
| germ-band shortening | The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo. |
| germ-line stem cell division | The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. |
| germ-line stem-cell niche homeostasis | A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion. |
| glucose homeostasis | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. |
| imaginal disc growth | The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. |
| insulin receptor signaling pathway | The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. |
| intestinal stem cell homeostasis | Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells. |
| lipid homeostasis | Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. |
| locomotory behavior | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. |
| lymph gland development | The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. |
| male germ-line stem cell asymmetric division | The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes. |
| multicellular organism growth | The increase in size or mass of an entire multicellular organism, as opposed to cell growth. |
| negative regulation of autophagy | Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| negative regulation of circadian sleep/wake cycle, sleep | Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. |
| negative regulation of entry into reproductive diapause | Any process that stops, prevents, or reduces the frequency, rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. |
| negative regulation of feeding behavior | Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior. |
| negative regulation of peptide hormone secretion | Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| open tracheal system development | The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster. |
| positive regulation of border follicle cell migration | Any process that activates or increases the frequency, rate or extent of border follicle cell migration. |
| positive regulation of cell growth | Any process that activates or increases the frequency, rate, extent or direction of cell growth. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of cell size | Any process that increases cell size. |
| positive regulation of fat cell proliferation | Any process that activates or increases the rate or extent of fat cell proliferation. |
| positive regulation of lipid storage | Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of multicellular organism growth | Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. |
| positive regulation of neuroblast proliferation | Any process that activates or increases the rate of neuroblast proliferation. |
| positive regulation of neuron remodeling | Any process that activates or increases the frequency, rate or extent of neuron remodeling. |
| positive regulation of organ growth | Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| positive regulation of wound healing | Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. |
| primary spermatocyte growth | The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| regulation of multicellular organism growth | Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. |
| regulation of organ growth | Any process that modulates the frequency, rate or extent of growth of an organ of an organism. |
| response to anoxia | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. |
| response to cocaine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| triglyceride homeostasis | Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. |
31 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05688 | IGF1R | Insulin-like growth factor 1 receptor | Bos taurus (Bovine) | SS |
| Q24488 | Ror | Tyrosine-protein kinase transmembrane receptor Ror | Drosophila melanogaster (Fruit fly) | SS |
| Q9V6K3 | Nrk | Tyrosine-protein kinase transmembrane receptor Ror2 | Drosophila melanogaster (Fruit fly) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P06213 | INSR | Insulin receptor | Homo sapiens (Human) | EV |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| P24062 | Igf1r | Insulin-like growth factor 1 receptor | Rattus norvegicus (Rat) | SS |
| P15127 | Insr | Insulin receptor | Rattus norvegicus (Rat) | SS |
| Q9SXB5 | At1g11303 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64783 | At1g61370 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64770 | At1g61490 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SYA0 | At1g61500 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LW83 | CES101 | G-type lectin S-receptor-like serine/threonine-protein kinase CES101 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81833 | SD11 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64774 | At1g61460 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64782 | SD129 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64776 | At1g61440 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SY95 | At1g61550 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64778 | At1g61420 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64780 | At1g61400 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64793 | At1g67520 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64784 | At1g61360 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39203 | SD22 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFNMPRGVTK | SKSKRGKIKM | ENDMAAAATT | TACTLGHICV | LCRQEMLLDT | CCCRQAVEAV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DSPASSEEAY | SSSNSSSCQA | SSEISAEEVW | FLSHDDIVLC | RRPKFDEVET | TGKKRDVKCS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GHQCSNECDD | GSTKNNRQQR | ENFNIFSNCH | NILRTLQSLL | LLMFNCGIFN | KRRRRQHQQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HHHHYQHHHQ | QHHQQHHQRQ | QANVSYTKFL | LLLQTLAAAT | TRLSLSPKNY | KQQQQLQHNQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QLPRATPQQK | QQEKDRHKCF | HYKHNYSYSP | GISLLLFILL | ANTLAIQAVV | LPAHQQHLLH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NDIADGLDKT | ALSVSGTQSR | WTRSESNPTM | RLSQNVKPCK | SMDIRNMVSH | FNQLENCTVI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EGFLLIDLIN | DASPLNRSFP | KLTEVTDYII | IYRVTGLHSL | SKIFPNLSVI | RGNKLFDGYA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LVVYSNFDLM | DLGLHKLRSI | TRGGVRIEKN | HKLCYDRTID | WLEILAENET | QLVVLTENGK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EKECRLSKCP | GEIRIEEGHD | TTAIEGELNA | SCQLHNNRRL | CWNSKLCQTK | CPEKCRNNCI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DEHTCCSQDC | LGGCVIDKNG | NESCISCRNV | SFNNICMDSC | PKGYYQFDSR | CVTANECITL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TKFETNSVYS | GIPYNGQCIT | HCPTGYQKSE | NKRMCEPCPG | GKCDKECSSG | LIDSLERARE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FHGCTIITGT | EPLTISIKRE | SGAHVMDELK | YGLAAVHKIQ | SSLMVHLTYG | LKSLKFFQSL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TEISGDPPMD | ADKYALYVLD | NRDLDELWGP | NQTVFIRKGG | VFFHFNPKLC | VSTINQLLPM |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LASKPKFFEK | SDVGADSNGN | RGSCGTAVLN | VTLQSVGANS | AMLNVTTKVE | IGEPQKPSNA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TIVFKDPRAF | IGFVFYHMID | PYGNSTKSSD | DPCDDRWKVS | SPEKSGVMVL | SNLIPYTNYS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| YYVRTMAISS | ELTNAESDVK | NFRTNPGRPS | KVTEVVATAI | SDSKINVTWS | YLDKPYGVLT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RYFIKAKLIN | RPTRNNNRDY | CTEPLVKAME | NDLPATTPTK | KISDPLAGDC | KCVEGSKKTS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SQEYDDRKVQ | AGMEFENALQ | NFIFVPNIRK | SKNGSSDKSD | GAEGAALDSN | AIPNGGATNP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| SRRRRDVALE | PELDDVEGSV | LLRHVRSITD | DTDAFFEKDD | ENTYKDEEDL | SSNKQFYEVF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| AKELPPNQTH | FVFEKLRHFT | RYAIFVVACR | EEIPSEKLRD | TSFKKSLCSD | YDTVFQTTKR |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| KKFADIVMDL | KVDLEHANNT | ESPVRVRWTP | PVDPNGEIVT | YEVAYKLQKP | DQVEEKKCIP |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| AADFNQTAGY | LIKLNEGLYS | FRVRANSIAG | YGDFTEVEHI | KVEPPPSYAK | VFFWLLGIGL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| AFLIVSLFGY | VCYLHKRKVP | SNDLHMNTEV | NPFYASMQYI | PDDWEVLREN | IIQLAPLGQG |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| SFGMVYEGIL | KSFPPNGVDR | ECAIKTVNEN | ATDRERTNFL | SEASVMKEFD | TYHVVRLLGV |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| CSRGQPALVV | MELMKKGDLK | SYLRAHRPEE | RDEAMMTYLN | RIGVTGNVQP | PTYGRIYQMA |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| IEIADGMAYL | AAKKFVHRDL | AARNCMVADD | LTVKIGDFGM | TRDIYETDYY | RKGTKGLLPV |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| RWMPPESLRD | GVYSSASDVF | SFGVVLWEMA | TLAAQPYQGL | SNEQVLRYVI | DGGVMERPEN |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| CPDFLHKLMQ | RCWHHRSSAR | PSFLDIIAYL | EPQCPNSQFK | EVSFYHSEAG | LQHREKERKE |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| RNQLDAFAAV | PLDQDLQDRE | QQEDATTPLR | MGDYQQNSSL | DQPPESPIAM | VDDQGSHLPF |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| SLPSGFIASS | TPDGQTVMAT | AFQNIPAAQG | DISATYVVPD | ADALDGDRGY | EIYDPSPKCA |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| ELPTSRSGST | GGGKLSGEQH | LLPRKGRQPT | IMSSSMPDDV | IGGSSLQPST | ASAGSSNASS |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| HTGRPSLKKT | VADSVRNKAN | FINRHLFNHK | RTGSNASHKS | NASNAPSTSS | NTNLTSHPVA |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| MGNLGTIESG | GSGSAGSYTG | TPRFYTPSAT | PGGGSGMAIS | DNPNYRLLDE | SIASEQATIL |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| TTSSPNPNYE | MMHPPTSLVS | TNPNYMPMNE | TPVQMAGVTI | SHNPNYQPMQ | APLNARQSQS |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| SSDEDNEQEE | DDEDEDDDVD | DEHVEHIKME | RMPLSRPRQR | ALPSKTQPPR | SRSVSQTRKS |
| 2110 | 2120 | 2130 | 2140 | ||
| PTNPNSGIGA | TGAGNRSNLL | KENWLRPAST | PRPPPPNGFI | GREA |