Descriptions

lab is a member of the Homeotic complex (HOX) family of homeoproteins that are required for specifying cell fates and morphological differences along the anterior-posterior axes of most animals. The lab hexapeptide(also called YPWM motif or pentapeptide) inhibits lab function and activates inappropriate target genes in vivo by inhibiting DNA binding. LAB-EXD interactions functions to remove the inhibitory effect of the hexapeptide and to enhance DNA binding to relevant target sequences by cooperative interactions.

Autoinhibitory domains (AIDs)

Target domain

223-287 (Homeodomain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P09022

Entry ID Method Resolution Chain Position Source
AF-P09022-F1 Predicted AlphaFoldDB

No variants for P09022

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P09022

No associated diseases with P09022

4 regional properties for P09022

Type Name Position InterPro Accession
domain Homeodomain 223 - 287 IPR001356
conserved_site Homeobox, conserved site 258 - 281 IPR017970
domain Homeodomain, metazoa 247 - 258 IPR020479-1
domain Homeodomain, metazoa 262 - 281 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

17 GO annotations of biological process

Name Definition
anatomical structure formation involved in morphogenesis The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
anatomical structure morphogenesis The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
anterior/posterior pattern specification The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
cellular response to ethanol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
cellular response to retinoic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
central nervous system neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
facial nerve structural organization The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
facial nucleus development The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.
hindbrain development The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
inner ear morphogenesis The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
motor neuron axon guidance The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
rhombomere 3 development The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
rhombomere 4 development The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
rhombomere 5 development The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P23459 HOXD8 Homeobox protein Hox-D8 Gallus gallus (Chicken) PR
A2T6Z0 HOXB1 Homeobox protein Hox-B1 Pan troglodytes (Chimpanzee) SS
P10105 lab Homeotic protein labial Drosophila melanogaster (Fruit fly) EV
P31268 HOXA7 Homeobox protein Hox-A7 Homo sapiens (Human) SS
P14653 HOXB1 Homeobox protein Hox-B1 Homo sapiens (Human) SS
P49639 HOXA1 Homeobox protein Hox-A1 Homo sapiens (Human) SS
O08656 Hoxa1 Homeobox protein Hox-A1 Rattus norvegicus (Rat) SS
A2D649 HOXB1 Homeobox protein Hox-B1 Macaca mulatta (Rhesus macaque) SS
P46603 HAT9 Homeobox-leucine zipper protein HAT9 Arabidopsis thaliana (Mouse-ear cress) PR
Q28IU6 hoxd1 Homeobox protein Hox-D1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q8JH55 hoxb8b Homeobox protein Hox-B8b Danio rerio (Zebrafish) (Brachydanio rerio) PR
F1Q4R9 meox1 Homeobox protein MOX-1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MNSFLEYPIL GSGDSGTCSA RAYPSDHGIT TFQSCAVSAN SCGGDDRFLV GRGVQISSPH
70 80 90 100 110 120
HHHHHHHHHH PQTATYQTSG NLGISYSHSS CGPSYGAQNF SAPYGPYGLN QEADVSGGYP
130 140 150 160 170 180
PCAPAVYSGN LSTPMVQHHH HHQGYAGGTV GSPQYIHHSY GQEQQTLALA TYNNSLSPLH
190 200 210 220 230 240
ASHQEACRSP ASETSSPAQT FDWMKVKRNP PKTGKVGEYG YVGQPNAVRT NFTTKQLTEL
250 260 270 280 290 300
EKEFHFNKYL TRARRVEIAA SLQLNETQVK IWFQNRRMKQ KKREKEGLLP ISPATPPGSD
310 320 330
EKTEESSEKS SPSPSAPSPA SSTSDTLTTS H