AiPD: Autoinhibited Protein Database

P08922

Gene name	ROS1 (MCF3, ROS)
Protein name	Proto-oncogene tyrosine-protein kinase ROS
Names	EC 2.7.10.1 , Proto-oncogene c-Ros , Proto-oncogene c-Ros-1 , Receptor tyrosine kinase c-ros oncogene 1 , c-Ros receptor tyrosine kinase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6098
EC number	2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

Ror2 (receptor tyrosine kinase-like orphan receptor 2, an unconventional Wnt receptor) may be involved in the early formation of chondrocytes and may be required for cartilage and growth plate development. Ror2 autoinhibition combines several elements. Its activation loop occludes the substrate- and ATP-binding sites and the interactions between the activation loop and αC helix in the N-terminal lobe stabilizes the autoinhibited state of Ror2.

Autoinhibitory domains (AIDs)

1991-2003 (αC helix) SS

Target domain	1945-2215 (Protein kinase domain)
Relief mechanism	Others
Assay

AID

1991-2003 (αC helix)

Target domain

1945-2215 (Protein kinase domain)

Relief mechanism

Others (Dissociation of DLG motif within the activation loop from αC helix)

Assay

Accessory elements

2101-2126 (Activation loop from InterPro)

Target domain	1945-2222 (Protein kinase domain)
Relief mechanism
Assay

References

Artim SC et al. (2012) "Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family", The Biochemical journal, 448, 213-20

Uchikawa E et al. (2019) "Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex", eLife, 8,

Nielsen J et al. (2022) "Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling", Journal of molecular biology, 434, 167458

Chen YS et al. (2021) "Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation", Proceedings of the National Academy of Sciences of the United States of America, 118,

Craddock BP et al. (2007) "Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region", FEBS letters, 581, 3235-40

Autoinhibited structure

Activated structure

5 structures for P08922

Entry ID	Method	Resolution	Chain	Position	Source
3ZBF	X-ray	220 A	A	1934-2232	PDB
4UXL	X-ray	240 A	A	1934-2232	PDB
7Z5W	X-ray	225 A	A/B	1930-2256	PDB
7Z5X	X-ray	204 A	A/B	1930-2256	PDB
AF-P08922-F1	Predicted				AlphaFoldDB

5678 variants for P08922

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA16602597 rs1057519788 RCV000418413	2032	G>R	Lung adenocarcinoma [ClinVar]	Yes	Ensembl ClinGen ClinVar dbSNP
COSM5023743 COSM5023742 rs2128753497	2	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1489703242	3	N>H		No	gnomAD
rs369466253	4	I>F		No	ESP TOPMed gnomAD
rs369466253	4	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP NCI-TCGA TOPMed gnomAD
rs2128753481	5	Y>F		No	Ensembl
rs1340793753	5	Y>H		No	gnomAD
rs754955040	6	C>S		No	ExAC gnomAD
rs754955040	6	C>Y		No	ExAC gnomAD
rs2128753469	7	L>F		No	Ensembl
rs1229447233	8	I>V		No	TOPMed gnomAD
rs770579408	9	P>L		No	ExAC TOPMed gnomAD
COSM3619927 COSM3619926	9	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1387124417	10	K>E		No	gnomAD
rs531081004	10	K>N		No	1000Genomes
rs772804887	11	L>P		No	ExAC TOPMed gnomAD
rs772804887	11	L>R		No	ExAC TOPMed gnomAD
rs1776082502	12	V>D		No	gnomAD
rs1429387157	12	V>I		No	gnomAD
rs45606237 VAR_041442	13	N>S		No	UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1170566188	15	A>V		No	gnomAD
rs1562400875	16	T>A		No	Ensembl
rs1464664635	16	T>I		No	TOPMed gnomAD
TCGA novel	16	T>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1464664635	16	T>N		No	TOPMed gnomAD
rs1562400875	16	T>P		No	Ensembl
rs776963776	17	L>F		No	ExAC gnomAD
rs2128753394	18	G>D		No	Ensembl
rs1435247456	18	G>S		No	gnomAD
rs2128753394	18	G>V		No	Ensembl
rs1179507437	19	C>R		No	gnomAD
COSM3994572 COSM3994573 rs747481675	19	C>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs747481675	19	C>Y		No	ExAC TOPMed gnomAD
TCGA novel rs2128753371	21	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128753371	21	W>C		No	Ensembl
COSM4505330 COSM4505331 rs1562400768	23	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
rs1251827246	24	V>A		No	TOPMed gnomAD
rs1251827246	24	V>E		No	TOPMed gnomAD
rs776025396	25	V>L		No	ExAC TOPMed gnomAD
rs776025396	25	V>M		No	ExAC TOPMed gnomAD
rs2128753344	26	Q>*		No	Ensembl
rs1776077709	26	Q>L		No	TOPMed
rs1776077709	26	Q>R		No	TOPMed
rs1776077506	27	C>R		No	TOPMed
rs2128753334	27	C>Y		No	Ensembl
rs924427270	28	T>K		No	TOPMed gnomAD
rs1776076888	29	V>D		No	TOPMed
rs2128753322	29	V>I		No	Ensembl
rs1776076278	33	C>G		No	TOPMed
rs2128753295	33	C>Y		No	Ensembl
rs1776075738	34	L>V		No	TOPMed
rs1776075507	35	K>N		No	TOPMed gnomAD
rs371523377	36	S>L		No	ESP TOPMed gnomAD
rs1287982877	36	S>L		No	gnomAD
rs779056086	37	C>S		No	ExAC
rs746635415	38	V>A		No	Ensembl
rs2128753225 TCGA novel	38	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
TCGA novel	39	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128753204	40	N>Y		No	Ensembl
rs1286253504	41	L>R		No	TOPMed gnomAD
rs757365700	41	L>V		No	ExAC gnomAD
rs2128746482	42	G>D		No	Ensembl
rs1775508919	42	G>S		No	Ensembl
rs1775508513	43	Q>R		No	TOPMed
rs376113207	44	Q>K		No	ESP ExAC TOPMed gnomAD
rs779908946	45	L>V		No	ExAC gnomAD
COSM3619925 COSM3619924 rs1775507306	47	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed gnomAD
COSM3697372 rs2128746440 COSM3697373	48	G>D	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs758251496	48	G>S		No	ExAC gnomAD
rs1460150065	49	T>A		No	TOPMed
rs1347271467	49	T>I		No	gnomAD
rs1347271467	49	T>R		No	gnomAD
rs778252640	50	P>L		No	ExAC gnomAD
rs778252640	50	P>R		No	ExAC gnomAD
rs1299679736	51	H>Y		No	TOPMed
COSM483334 COSM1645900	53	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs916990656	53	L>R		No	Ensembl
rs756807424	54	S>R		No	ExAC TOPMed gnomAD
rs1163527213	54	S>R		No	gnomAD
TCGA novel	55	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs553213552	56	P>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs753367775	56	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2128746379	56	P>S		No	Ensembl
rs1775327594	57	C>Y		No	TOPMed
rs1562388720	59	Q>*		No	Ensembl
rs778854057	59	Q>P		No	ExAC gnomAD
rs1775326733	60	G>*		No	TOPMed
rs1251092701	60	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1020449619	61	C>Y		No	TOPMed gnomAD
rs757191782	62	H>Q		No	ExAC TOPMed gnomAD
rs1775325640	63	F>L		No	Ensembl
rs1219188453	64	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
COSM3619923 COSM3619922 rs1346089547	65	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs758953330	67	V>A		No	Ensembl
rs2128744294	67	V>I		No	Ensembl
rs1285596214	68	D>Y		No	gnomAD
rs1775324534	69	Q>E		No	TOPMed gnomAD
rs1775324307	69	Q>L		No	TOPMed
rs753306008	71	N>H		No	ExAC gnomAD
rs1241089279	72	C>*		No	TOPMed
COSM1072638 COSM4867278	72	C>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs777286880	74	L>V		No	ExAC gnomAD
rs1775322732	75	K>*		No	Ensembl
rs755740564	76	C>R		No	ExAC gnomAD
rs140860347	77	R>P		No	ESP ExAC gnomAD
rs140860347	77	R>Q		No	ESP ExAC gnomAD
rs746684942	77	R>W		No	ExAC TOPMed gnomAD
rs758893022	78	E>Q		No	ExAC TOPMed
rs150941257	79	S>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs757736576	80	C>R		No	ExAC TOPMed gnomAD
rs1774738285	80	C>W		No	TOPMed
rs1373871205	81	E>D		No	TOPMed
rs1405807699	82	V>G		No	gnomAD
rs1774737792	82	V>I		No	TOPMed
rs2128735130	83	G>D		No	Ensembl
rs753907292	84	C>F		No	ExAC TOPMed gnomAD
rs753907292	84	C>Y		No	ExAC TOPMed gnomAD
rs1774736707	85	S>I		No	Ensembl
rs369171859	85	S>R		No	ESP ExAC TOPMed gnomAD
rs775755714	86	S>G		No	ExAC TOPMed gnomAD
rs2128735094	86	S>N		No	Ensembl
rs545356487	86	S>R		No	1000Genomes ExAC TOPMed gnomAD
rs145609658	87	A>G		No	ESP ExAC TOPMed gnomAD
COSM3157950 COSM3157951 rs376101389	87	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs145609658	87	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1295924873	88	E>A		No	TOPMed gnomAD
rs1295924873	88	E>G		No	TOPMed gnomAD
rs2128735058	88	E>K		No	Ensembl
rs2128735041	89	G>C		No	Ensembl
rs2128735041	89	G>S		No	Ensembl
rs1774733694	90	A>T		No	TOPMed
rs2128735022	90	A>V		No	Ensembl
rs2128735018	92	E>K		No	Ensembl
rs1202390995	93	E>G		No	TOPMed gnomAD
rs1774733223	93	E>K		No	TOPMed
rs1202390995	93	E>V		No	TOPMed gnomAD
rs576811751	94	E>A		No	1000Genomes ExAC gnomAD
rs373938735	94	E>K		No	TOPMed gnomAD
rs373938735	94	E>Q		No	TOPMed gnomAD
rs1774731684	95	V>I		No	TOPMed
rs1562379765	96	L>V		No	Ensembl
rs771857560	97	E>*		No	ExAC TOPMed gnomAD
rs771857560	97	E>K		No	ExAC TOPMed gnomAD
rs1386947086	98	N>D		No	gnomAD
rs771802350	98	N>K		No	ExAC TOPMed gnomAD
rs1386947086	98	N>Y		No	gnomAD
rs1226977360	99	A>E		No	TOPMed gnomAD
rs2128727040	99	A>P		No	Ensembl
rs1226977360	99	A>V		No	TOPMed gnomAD
rs1582866217	100	D>A		No	Ensembl
rs2128727007	100	D>E		No	Ensembl
rs2128727016	100	D>H		No	Ensembl
rs1582866217	100	D>V		No	Ensembl
rs2128727016	100	D>Y		No	Ensembl
rs532503107	101	L>I		No	1000Genomes ExAC gnomAD
rs771267442	103	T>A		No	ExAC TOPMed gnomAD
rs2128726979	103	T>I		No	Ensembl
rs771267442	103	T>P		No	ExAC TOPMed gnomAD
rs2128726979	103	T>S		No	Ensembl
rs771267442	103	T>S		No	ExAC TOPMed gnomAD
rs1774226659	104	A>D		No	gnomAD
rs2128726964	104	A>P		No	Ensembl
rs2128726964	104	A>T		No	Ensembl
rs1774226659	104	A>V		No	gnomAD
rs1774226111	105	P>A		No	Ensembl
rs767519397	105	P>L		No	ExAC TOPMed gnomAD
rs767519397	105	P>R		No	ExAC TOPMed gnomAD
rs1774226111	105	P>S		No	Ensembl
rs2128726920	106	F>I		No	Ensembl
rs2128726919	106	F>L		No	Ensembl
rs2128726920	106	F>L		No	Ensembl
rs2128726920	106	F>V		No	Ensembl
rs1774224661	107	A>D		No	TOPMed
rs752731431	107	A>T		No	ExAC gnomAD
rs781268704	108	S>C		No	ExAC TOPMed gnomAD
rs781268704	108	S>F		No	ExAC TOPMed gnomAD
rs2128726906	108	S>T		No	Ensembl
rs781268704	108	S>Y		No	ExAC TOPMed gnomAD
rs2128726871	109	S>C		No	Ensembl
rs2128726871	109	S>F		No	Ensembl
rs995478812	109	S>P		No	Ensembl
rs995478812	109	S>T		No	Ensembl
rs2128726871	109	S>Y		No	Ensembl
rs751815622	110	I>T		No	ExAC TOPMed gnomAD
rs755166521	110	I>V		No	ExAC gnomAD
rs2128726850	111	G>*		No	Ensembl
rs2128726841	111	G>A		No	Ensembl
rs2128726841	111	G>E		No	Ensembl
rs2128726850 COSM5061362 COSM5061363	111	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA Cosmic
rs2128726841	111	G>V		No	Ensembl
rs2128726831	112	S>C		No	Ensembl
rs2128726831	112	S>G		No	Ensembl
rs765071235	112	S>I		No	ExAC gnomAD
rs765071235	112	S>N		No	ExAC gnomAD
rs2128726809 COSM125926	112	S>R	upper_aerodigestive_tract [Cosmic]	No	cosmic curated Ensembl
rs765071235	112	S>T		No	ExAC gnomAD
rs2128726793	113	H>Q		No	Ensembl
rs897147463	113	H>Y		No	TOPMed
rs1382176433	114	N>I		No	TOPMed gnomAD
rs1316297212	114	N>K		No	gnomAD
rs1382176433	114	N>S		No	TOPMed gnomAD
TCGA novel	114	N>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128726769	115	M>I		No	Ensembl
rs2128726778	115	M>L		No	Ensembl
rs761461938	116	T>I		No	ExAC TOPMed gnomAD
rs761461938	116	T>K		No	ExAC TOPMed gnomAD
rs761461938	116	T>R		No	ExAC TOPMed gnomAD
rs2128726736	117	L>*		No	Ensembl
rs374639065	118	R>*		No	ESP ExAC TOPMed gnomAD
rs374639065 COSM136564	118	R>G	skin [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs867759865	118	R>L		No	TOPMed gnomAD
rs867759865	118	R>P		No	TOPMed gnomAD
COSM1072635 rs867759865 COSM1072633 COSM3429917	118	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1388562198	119	W>*		No	TOPMed gnomAD
rs2128726704	119	W>*		No	Ensembl
rs1388562198	119	W>C		No	TOPMed gnomAD
rs1159992483	119	W>R		No	gnomAD
rs2128726704	119	W>S		No	Ensembl
rs2128726692	120	K>I		No	Ensembl
rs1177498366	120	K>Q		No	Ensembl
rs2128726692	120	K>R		No	Ensembl
rs2128726681	121	S>A		No	Ensembl
rs2128726676	121	S>C		No	Ensembl
rs2128726676	121	S>F		No	Ensembl
rs2128726681	121	S>T		No	Ensembl
rs763901089	122	A>E		No	ExAC TOPMed gnomAD
rs763901089	122	A>G		No	ExAC TOPMed gnomAD
rs1455911125	122	A>P		No	gnomAD
rs1455911125	122	A>T		No	gnomAD
COSM1173172 rs763901089 COSM1173173	122	A>V	oesophagus [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs2128726635	123	N>D		No	Ensembl
rs2128726635	123	N>H		No	Ensembl
rs1774218848	123	N>I		No	TOPMed
rs2128726625	123	N>K		No	Ensembl
rs1774218848	123	N>S		No	TOPMed
rs2128726635	123	N>Y		No	Ensembl
rs370602941	124	F>C		No	ESP ExAC TOPMed gnomAD
rs1774218568	124	F>I		No	Ensembl
rs2128726607	124	F>L		No	Ensembl
rs1774218568	124	F>L		No	Ensembl
rs370602941	124	F>Y		No	ESP ExAC TOPMed gnomAD
rs775119219	125	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs775119219	125	S>F		No	ExAC TOPMed gnomAD
rs2128726603	125	S>T		No	Ensembl
rs2128726592	126	G>*		No	Ensembl
rs34245787	126	G>A		No	TOPMed
COSM3619918 rs34245787 COSM3619919	126	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs2128726592	126	G>R		No	Ensembl
rs34245787 VAR_041443	126	G>V		No	UniProt TOPMed dbSNP
rs2128726553	127	V>A		No	Ensembl
rs2128726553	127	V>E		No	Ensembl
rs2128726572	127	V>I		No	Ensembl
rs2128726572	127	V>L		No	Ensembl
rs2128726540	128	K>*		No	Ensembl
rs2128726540	128	K>E		No	Ensembl
rs2128726536	128	K>I		No	Ensembl
rs2128726534	128	K>N		No	Ensembl
rs747973168	129	Y>*		No	Ensembl
rs2128726532	129	Y>F		No	Ensembl
rs1774216427	130	I>F		No	TOPMed gnomAD
rs2128726504	130	I>M		No	Ensembl
rs759258218	130	I>N		No	ExAC gnomAD
rs1774216427	130	I>V		No	TOPMed gnomAD
rs2128726502	131	I>F		No	Ensembl
rs2128726489	131	I>N		No	Ensembl
rs1774215910	132	Q>*		No	Ensembl
rs1774215910	132	Q>E		No	Ensembl
rs1774215639	132	Q>H		No	gnomAD
rs2128726479	132	Q>L		No	Ensembl
rs2128726463	133	W>*		No	Ensembl
rs867025812	133	W>*		No	Ensembl
rs867025812	133	W>C		No	Ensembl
rs2128726463	133	W>L		No	Ensembl
rs201807486	133	W>R		No	1000Genomes ExAC TOPMed gnomAD
rs2128726463	133	W>S		No	Ensembl
rs2128726454	134	K>I		No	Ensembl
rs770628464	135	Y>*		No	ExAC TOPMed gnomAD
rs746896316	135	Y>*		No	ExAC
rs2128726440	135	Y>F		No	Ensembl
rs1306678916	135	Y>H		No	gnomAD
rs1306678916	135	Y>N		No	gnomAD
rs2128726426	136	A>G		No	Ensembl
rs2128726434	136	A>P		No	Ensembl
rs2128726434	136	A>S		No	Ensembl
rs2128726434	136	A>T		No	Ensembl
rs2128726426	136	A>V		No	Ensembl
rs1774214350	137	Q>*		No	TOPMed
rs1774214350	137	Q>E		No	TOPMed
rs2128726410	137	Q>H		No	Ensembl
rs1774214350	137	Q>K		No	TOPMed
rs375619431	138	L>F		No	ESP ExAC TOPMed gnomAD
rs1774213824	138	L>H		No	TOPMed
rs1774213824	138	L>P		No	TOPMed
rs375619431	138	L>V		No	ESP ExAC TOPMed gnomAD
TCGA novel	139	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128726379	139	L>Q		No	Ensembl
rs2128726379	139	L>R		No	Ensembl
rs2128726386	139	L>V		No	Ensembl
rs2128726365	140	G>*		No	Ensembl
rs2128726348	140	G>A		No	Ensembl
rs2128726348	140	G>E		No	Ensembl
rs2128726365	140	G>R		No	Ensembl
rs773654547	141	S>C		No	ExAC gnomAD
rs773654547	141	S>G		No	ExAC gnomAD
rs2128726332	141	S>I		No	Ensembl
rs2128726323	141	S>R		No	Ensembl
rs2128726332	141	S>T		No	Ensembl
rs2128726303	142	W>*		No	Ensembl
TCGA novel rs2128726291	142	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128726291	142	W>C		No	Ensembl
rs373796868	142	W>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs373796868 RCV000908623	142	W>R		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2128726303	142	W>S		No	Ensembl
rs2128726284	143	T>I		No	Ensembl
rs2128726284	143	T>S		No	Ensembl
rs1582865569	144	Y>*		No	TOPMed
rs1340640500	144	Y>C		No	gnomAD
TCGA novel	144	Y>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128726274	144	Y>N		No	Ensembl
rs961074372	145	T>I		No	TOPMed gnomAD
rs1998206 VAR_030648	145	T>P		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2128726240	146	K>*		No	Ensembl
rs2128726240	146	K>E		No	Ensembl
rs2128726231	146	K>M		No	Ensembl
COSM4785858 COSM1440109	146	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	146	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128726231	146	K>R		No	Ensembl
rs1201922933	147	T>I		No	gnomAD
rs1201922933	147	T>N		No	gnomAD
rs1582862111	148	V>A		No	Ensembl
COSM4785530 COSM1440107	148	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs549177200	151	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs549177200	151	P>R		No	1000Genomes ExAC TOPMed gnomAD
rs1279832487	152	S>F		No	TOPMed
rs1774104819	152	S>P		No	Ensembl
rs752552490	153	Y>C		No	ExAC TOPMed gnomAD
rs1190441982	153	Y>D		No	TOPMed
rs113723823	154	V>A		No	TOPMed
rs1774102862	155	V>A		No	TOPMed
rs1774103053	155	V>I		No	TOPMed gnomAD
rs905402237	156	K>E		No	TOPMed gnomAD
rs1774102405	157	P>A		No	Ensembl
rs1215188906	158	L>M		No	gnomAD
TCGA novel	158	L>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs765959636	159	H>P		No	ExAC gnomAD
rs750152817	159	H>Q		No	ExAC gnomAD
rs2128724406	159	H>Y		No	Ensembl
rs1774100802	161	F>L		No	Ensembl
rs1774100603	162	T>I		No	Ensembl
rs2128724377	163	E>Q		No	Ensembl
rs1436374132	164	Y>C		No	TOPMed
rs180777109	164	Y>H		No	1000Genomes ExAC TOPMed gnomAD
rs180777109	164	Y>N		No	1000Genomes ExAC TOPMed gnomAD
rs769105985	167	R>*		No	ExAC gnomAD
rs769105985	167	R>G		No	ExAC gnomAD
rs2243380	167	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2243380 VAR_030649	167	R>Q		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1334656084	168	V>G		No	gnomAD
rs2128724330	168	V>M		No	Ensembl
rs898152846	169	V>D		No	TOPMed gnomAD
rs1774097984	169	V>F		No	TOPMed
rs1774098543	169	V>I		No	Ensembl
rs1774097984	169	V>L		No	TOPMed
rs1178798860	170	W>C		No	gnomAD
rs1417557820	172	F>S		No	gnomAD
rs2128724286	173	T>I		No	Ensembl
rs1407611836	173	T>P		No	gnomAD
rs772261492	174	A>E		No	ExAC TOPMed gnomAD
rs772261492	174	A>V		No	ExAC TOPMed gnomAD
COSM117963 rs2128724265	177	Q>*	ovary [Cosmic]	No	cosmic curated Ensembl
rs373315543	177	Q>R		No	ESP ExAC gnomAD
rs771282907	178	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs771282907	178	L>I		No	ExAC TOPMed gnomAD
rs747911152	179	Y>C		No	ExAC TOPMed gnomAD
COSM4902471 COSM4902472	180	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs754846972	181	P>S		No	ExAC TOPMed gnomAD
rs2128724228	182	P>T		No	Ensembl
rs751553775	183	S>G		No	ExAC gnomAD
rs2128724215	184	P>H		No	Ensembl
rs757981971	185	S>G		No	ExAC gnomAD
rs1419160274	185	S>I		No	TOPMed gnomAD
rs749944544	187	R>G		No	ExAC gnomAD
rs1774092614	187	R>K		No	Ensembl
rs1774092199	188	T>I		No	Ensembl
rs1774092408	188	T>P		No	Ensembl
COSM1697844 COSM1697843 rs764834127	189	H>N	skin [Cosmic]	No	cosmic curated ExAC gnomAD
rs1338468574	189	H>Q		No	TOPMed gnomAD
COSM3828904 COSM3828903	189	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128724167	190	P>L		No	1000Genomes
rs1451448120	190	P>S		No	gnomAD
rs761479222	191	H>D		No	ExAC TOPMed gnomAD
rs754183720	191	H>P		No	ExAC TOPMed gnomAD
rs754183720	191	H>R		No	ExAC TOPMed gnomAD
rs761479222	191	H>Y		No	ExAC TOPMed gnomAD
COSM3619915 COSM3619914	192	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs761084079	193	V>I		No	ExAC gnomAD
rs1298952570 COSM421099 COSM3157931 COSM421100	194	P>S	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs766602764	195	E>Q		No	ExAC gnomAD
rs763259655	196	T>I		No	ExAC gnomAD
rs2128716964	197	A>T		No	Ensembl
COSM95213 rs1302819459	198	P>L	lung [Cosmic]	No	cosmic curated gnomAD
rs769919414	198	P>S		No	ExAC TOPMed gnomAD
rs769919414	198	P>T		No	ExAC TOPMed gnomAD
rs746782086	200	I>V		No	ExAC gnomAD
rs775173615	201	R>G		No	ExAC gnomAD
rs1296913853	201	R>S		No	gnomAD
rs377231905	202	N>H		No	ESP ExAC gnomAD
rs564942341	203	I>N		No	1000Genomes ExAC TOPMed gnomAD
rs564942341	203	I>T		No	1000Genomes ExAC TOPMed gnomAD
rs1773550940	203	I>V		No	Ensembl
rs1009843617	204	E>K		No	TOPMed gnomAD
rs1009843617	204	E>Q		No	TOPMed gnomAD
rs148499825	205	S>G		No	ESP ExAC TOPMed gnomAD
rs1426748283	205	S>N		No	TOPMed gnomAD
rs148499825	205	S>R		No	ESP ExAC TOPMed gnomAD
rs2128716887	206	S>L		No	Ensembl
rs1052820169	207	S>G		No	TOPMed gnomAD
rs1052820169	207	S>R		No	TOPMed gnomAD
rs2128716867 TCGA novel	208	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs755751748	209	D>G		No	ExAC TOPMed gnomAD
rs777419401	209	D>H		No	ExAC TOPMed gnomAD
rs777419401	209	D>N		No	ExAC TOPMed gnomAD
rs1691833635	210	T>A		No	Ensembl
rs2128716827	211	V>M		No	Ensembl
rs372381027	212	E>K		No	ESP ExAC TOPMed gnomAD
rs372381027	212	E>Q		No	ESP ExAC TOPMed gnomAD
rs868334441	214	S>N		No	TOPMed gnomAD
rs868334441	214	S>T		No	TOPMed gnomAD
rs1200269574	216	D>N		No	gnomAD
rs752174345	217	P>L		No	ExAC TOPMed gnomAD
rs752174345	217	P>Q		No	ExAC TOPMed gnomAD
rs142201886	217	P>T		No	ESP ExAC TOPMed gnomAD
rs1773545679	218	P>L		No	gnomAD
rs766551627	218	P>S		No	ExAC gnomAD
rs763066523	219	Q>*		No	ExAC gnomAD
rs773199682	219	Q>R		No	ExAC TOPMed gnomAD
rs2128716742	220	F>S		No	Ensembl
rs2128716732	221	P>S		No	Ensembl
rs2128716720	222	G>C		No	Ensembl
rs1773543979	222	G>D		No	Ensembl
rs1240410063	223	G>E		No	gnomAD
rs2128716710	223	G>R		No	Ensembl
rs771923036	224	P>H		No	ExAC gnomAD
rs771923036	224	P>L		No	ExAC gnomAD
rs55959124 RCV000879585 VAR_041444	224	P>S		No	ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs770860620	226	L>S		No	ExAC gnomAD
rs770860620	226	L>W		No	ExAC gnomAD
rs1459152647	227	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs2128716667 RCV001728070	227	G>S		No	ClinVar Ensembl dbSNP
rs1253255306	228	Y>C		No	Ensembl
rs1773541562	228	Y>H		No	Ensembl
rs747824037	229	N>K		No	ExAC gnomAD
rs970148457	230	L>S		No	TOPMed gnomAD
rs2128716623	231	R>M		No	Ensembl
rs2128716627	231	R>W		No	Ensembl
rs137969966	233	I>N		No	ESP ExAC TOPMed gnomAD
rs939993004	234	S>G		No	Ensembl
rs1773539651	234	S>I		No	gnomAD
rs1773539651	234	S>N		No	gnomAD
rs939993004	234	S>R		No	Ensembl
rs1773539351	235	K>R		No	gnomAD
rs1773539351	235	K>T		No	gnomAD
COSM3619910 rs747794595 COSM3619911	237	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs747794595	237	Q>E		No	ExAC TOPMed gnomAD
rs781612376	237	Q>H		No	ExAC
rs747794595	237	Q>K		No	ExAC TOPMed gnomAD
rs1773538215	239	L>F		No	TOPMed
rs751983911	240	D>H		No	ExAC TOPMed gnomAD
rs780637099	240	D>V		No	ExAC gnomAD
rs751983911	240	D>Y		No	ExAC TOPMed gnomAD
rs554606784	241	A>S		No	1000Genomes ExAC gnomAD
rs554606784	241	A>T		No	1000Genomes ExAC gnomAD
rs750496946	242	G>E		No	ExAC
rs765277219	243	T>A		No	ExAC gnomAD
COSM3366272 COSM3366271	243	T>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1773535955	244	Q>*		No	TOPMed
rs1204481074	244	Q>P		No	gnomAD
COSM4865309 COSM1072629	245	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs754066414	246	T>I		No	ExAC TOPMed gnomAD
rs759261834	248	F>Y		No	ExAC gnomAD
rs1674306855	249	Q>E		No	TOPMed gnomAD
COSM4864701 COSM1072626	250	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774163740	251	Y>H		No	ExAC gnomAD
rs150306025	252	S>A		No	ESP ExAC TOPMed gnomAD
TCGA novel	252	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs150306025	252	S>T		No	ESP ExAC TOPMed gnomAD
rs955421054	253	T>A		No	TOPMed
rs955421054	253	T>S		No	TOPMed
rs772747487	254	L>F		No	ExAC gnomAD
rs1337789269	255	P>S		No	TOPMed gnomAD
rs372009449	258	I>M		No	ESP ExAC TOPMed gnomAD
rs921368375	258	I>V		No	TOPMed gnomAD
rs1403866070	259	Y>C		No	gnomAD
rs1773532310	259	Y>N		No	gnomAD
rs1156495510	260	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1337780875	262	S>P		No	gnomAD
rs1269992033	263	I>L		No	TOPMed gnomAD
rs1269992033	263	I>V		No	TOPMed gnomAD
rs2128715573	264	A>T		No	Ensembl
rs1773476999	264	A>V		No	gnomAD
rs746701860	265	A>G		No	ExAC TOPMed gnomAD
rs1562361642	265	A>T		No	Ensembl
rs746701860	265	A>V		No	ExAC TOPMed gnomAD
rs1340735325	267	N>D		No	TOPMed gnomAD
rs780565452	267	N>T		No	ExAC TOPMed gnomAD
rs886999412	270	G>A		No	gnomAD
rs886999412	270	G>D		No	gnomAD
rs2128715507	272	G>C		No	Ensembl
rs2128715498	272	G>D		No	Ensembl
rs370121653	273	P>A		No	ESP TOPMed
rs370121653	273	P>S		No	ESP TOPMed
TCGA novel	273	P>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2128715469	274	E>G		No	Ensembl
TCGA novel	274	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1562361544	275	A>T		No	Ensembl
rs1773473726	276	E>*		No	TOPMed
rs1773473229	277	S>F		No	gnomAD
rs1773473508	277	S>T		No	Ensembl
rs1773473229	277	S>Y		No	gnomAD
rs899835248	278	S>G		No	TOPMed gnomAD
rs775196449	279	I>T		No	Ensembl
rs1773471962	282	S>L		No	TOPMed
rs113942409	282	S>P		No	Ensembl
rs1426025238	283	S>F		No	gnomAD
rs1426025238	283	S>Y		No	gnomAD
rs2128715377	285	A>P		No	Ensembl
rs1773471237	285	A>V		No	gnomAD
rs1322402703	286	V>A		No	TOPMed gnomAD
rs542417250	286	V>F		No	1000Genomes ExAC gnomAD
rs542417250	286	V>I		No	1000Genomes ExAC gnomAD
rs1773357325	287	Q>E		No	TOPMed gnomAD
rs1773357083	287	Q>L		No	Ensembl
rs2128713681	289	E>V		No	Ensembl
rs371206741	290	E>*		No	ESP ExAC TOPMed gnomAD
rs371206741	290	E>K		No	ESP ExAC TOPMed gnomAD
rs371206741	290	E>Q		No	ESP ExAC TOPMed gnomAD
rs189516374	291	Q>*		No	1000Genomes ExAC TOPMed gnomAD
rs189516374	291	Q>E		No	1000Genomes ExAC TOPMed gnomAD
rs989723092	291	Q>P		No	TOPMed gnomAD
TCGA novel rs989723092	291	Q>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1378760239	292	W>*		No	gnomAD
rs1378760239	292	W>C		No	gnomAD
rs868473694	293	L>F		No	gnomAD
rs755256160	294	F>L		No	ExAC gnomAD
rs1773353857	296	S>F		No	TOPMed
rs2128713622	297	R>I		No	Ensembl
TCGA novel	298	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs757140194	299	T>I		No	ExAC gnomAD
rs201937922	300	S>A		No	ExAC TOPMed gnomAD
rs201937922	300	S>P		No	ExAC TOPMed gnomAD
rs1183336300	300	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
TCGA novel	302	R>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs775172177	303	K>R		No	ExAC gnomAD
COSM4866945 COSM1072623	304	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1211839682	304	R>S		No	gnomAD
TCGA novel	305	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs767029887	306	L>*		No	ExAC gnomAD
rs1420516084	306	L>F		No	TOPMed gnomAD
rs2128713552	309	L>V		No	Ensembl
rs1773350089	311	D>E		No	Ensembl
COSM4947904 COSM1440105	312	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs957712386	313	A>T		No	TOPMed
rs140108938	314	H>L		No	ESP ExAC TOPMed gnomAD
rs140108938	314	H>R		No	ESP ExAC TOPMed gnomAD
rs773650993	317	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
COSM136563 COSM1739214 rs200113895	317	R>W	NS skin [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1025021082	318	L>M		No	TOPMed gnomAD
rs1012331801	319	D>G		No	TOPMed gnomAD
rs1773347942	319	D>N		No	Ensembl
rs1012331801	319	D>V		No	TOPMed gnomAD
rs1773346851	320	A>D		No	Ensembl
rs148185831	320	A>P		No	ESP ExAC TOPMed gnomAD
rs148185831	320	A>T		No	ESP ExAC TOPMed gnomAD
rs781352657	321	I>M		No	ExAC gnomAD
rs1421644123	321	I>V		No	gnomAD
rs146159167	323	H>N		No	ESP ExAC TOPMed gnomAD
rs551116874	323	H>R		No	1000Genomes ExAC TOPMed gnomAD
rs753691208	325	I>T		No	ExAC TOPMed gnomAD
rs756144218	326	T>R		No	ExAC TOPMed gnomAD
rs2128713040	327	G>A		No	Ensembl
COSM3619908 COSM3619909	327	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772455106	331	D>G		No	ExAC TOPMed gnomAD
rs772455106	331	D>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1773316770	333	H>Y		No	Ensembl
rs2128713018	334	Q>*		No	Ensembl
rs1773316499	334	Q>H		No	gnomAD
rs1220701751	335	Q>*		No	gnomAD
rs1220701751	335	Q>K		No	gnomAD
rs749044063	337	V>F		No	ExAC TOPMed gnomAD
rs749044063	337	V>I		No	ExAC TOPMed gnomAD
COSM6172031 COSM6172030	337	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs55707658 VAR_041445	338	Y>C		No	UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1773315200	340	S>F		No	Ensembl
rs756089152	340	S>P		No	ExAC TOPMed gnomAD
rs2128712983	341	E>*		No	Ensembl
rs752745358	341	E>D		No	ExAC gnomAD
rs1773314733	343	T>I		No	TOPMed
rs1297010018	344	L>V		No	gnomAD
rs2128712967	346	W>*		No	Ensembl
COSM364048 rs2128712961 COSM364047	346	W>C	lung [Cosmic]	No	cosmic curated Ensembl
COSM3157902 COSM3157901 rs780553416	347	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1218175401	348	K>E		No	TOPMed gnomAD
rs2128712948	348	K>N		No	Ensembl
rs751035291	349	K>*		No	ExAC TOPMed gnomAD
rs751035291	349	K>E		No	ExAC TOPMed gnomAD
rs765972514	350	A>P		No	ExAC gnomAD
COSM1440103 COSM4783946	350	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs765972514	350	A>T		No	ExAC gnomAD
rs2128712924	351	A>S		No	Ensembl
rs1426852418	351	A>V		No	gnomAD
rs1773312511	352	N>I		No	Ensembl
rs1197516016	352	N>K		No	gnomAD
rs376663875	353	M>I		No	ESP ExAC TOPMed
rs1026474078	353	M>R		No	Ensembl
rs1026474078	353	M>T		No	Ensembl
rs1773311321	354	S>T		No	TOPMed
TCGA novel	354	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128712871	355	D>N		No	Ensembl
rs1773310568	356	V>I		No	TOPMed
rs1773310568	356	V>L		No	TOPMed
rs1773310064	357	S>C		No	Ensembl
rs1175443727	359	L>M		No	gnomAD
rs2128712835	359	L>P		No	Ensembl
rs769599473 COSM1072618 COSM1072620 COSM1672712	360	R>I	Variant assessed as Somatic; MODERATE impact. large_intestine endometrium haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1238577631	361	I>S		No	gnomAD
rs1238577631	361	I>T		No	gnomAD
rs1773308549	362	F>L		No	Ensembl
rs1562358765	363	Y>F		No	gnomAD
COSM294782 rs1392239785	363	Y>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
RCV002248663 CA3975659 rs61743088 RCV000454139 RCV003424002	365	G>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs61743088	365	G>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs373813252	365	G>S		No	ESP ExAC TOPMed
rs2128712760	367	G>R		No	Ensembl
COSM3920645 COSM3920644	368	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3697473 COSM3697472 VAR_041446 rs56274823	370	S>P	large_intestine [Cosmic]	No	cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
COSM4947028 COSM76281 rs957763915	370	S>Y	ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1773306049	371	S>P		No	TOPMed
rs772402190	372	I>F		No	ExAC gnomAD
rs1376184246	372	I>S		No	Ensembl
rs772402190	372	I>V		No	ExAC gnomAD
rs2128712716	373	S>F		No	Ensembl
rs1582835479	374	I>K		No	Ensembl
rs923637371	374	I>L		No	TOPMed
rs746135095	375	D>E		No	ExAC TOPMed gnomAD
COSM5744897 COSM5744898	375	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs773134065	376	W>R		No	1000Genomes ExAC gnomAD
rs1378031096	377	L>F		No	TOPMed gnomAD
rs1378031096	377	L>V		No	TOPMed gnomAD
rs781116397	378	Y>*		No	ExAC gnomAD
rs1773303300	378	Y>F		No	Ensembl
rs369960949	378	Y>H		No	ESP ExAC TOPMed gnomAD
rs1403417515	379	Q>E		No	TOPMed gnomAD
rs1403417515	379	Q>K		No	TOPMed gnomAD
rs1466068877 COSM202100 COSM202101	380	R>I	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA TOPMed gnomAD
rs1466068877	380	R>T		No	TOPMed gnomAD
rs1216078562	381	M>T		No	TOPMed gnomAD
rs1773300662	382	Y>*		No	TOPMed
rs746475409	382	Y>C		No	ExAC gnomAD
rs145259410	382	Y>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs936476170	383	F>V		No	Ensembl
COSM1647861 COSM739464	384	I>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128712608	385	M>I		No	Ensembl
TCGA novel	385	M>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs565037039	385	M>T		No	1000Genomes ExAC TOPMed gnomAD
rs758013138	386	D>E		No	ExAC gnomAD
rs1190652673	386	D>H		No	TOPMed gnomAD
rs750137132	387	E>G		No	ExAC gnomAD
rs2128711133	389	V>E		No	Ensembl
rs1360638449	389	V>I		No	TOPMed gnomAD
rs1360638449	389	V>L		No	TOPMed gnomAD
rs997358663	390	C>R		No	TOPMed gnomAD
rs997358663	390	C>S		No	TOPMed gnomAD
rs2128711118	390	C>S		No	Ensembl
rs2128711109	391	V>F		No	Ensembl
rs2128711109	391	V>L		No	Ensembl
rs2128711098	392	C>R		No	Ensembl
rs2128711092	392	C>S		No	Ensembl
rs1163617062	393	D>E		No	gnomAD
rs768400134	393	D>H		No	ExAC TOPMed gnomAD
rs768400134	393	D>N		No	ExAC TOPMed gnomAD
rs768400134	393	D>Y		No	ExAC TOPMed gnomAD
rs2128711070	394	L>*		No	Ensembl
rs2128711065	394	L>F		No	Ensembl
rs2128711074	394	L>I		No	Ensembl
rs2128711054	395	E>*		No	Ensembl
COSM1072615 COSM1072617 rs2128711045 COSM4865754	395	E>D	endometrium Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated Ensembl NCI-TCGA Cosmic
rs2128711054	395	E>K		No	Ensembl
rs2128711054	395	E>Q		No	Ensembl
rs2128711049	395	E>V		No	Ensembl
rs2128711033	396	N>I		No	Ensembl
rs2128711026	396	N>K		No	Ensembl
rs2128711037	396	N>Y		No	Ensembl
rs1459296351	397	C>S		No	gnomAD
rs2128711020	397	C>S		No	Ensembl
rs2128711000	397	C>W		No	Ensembl
rs1459296351	397	C>Y		No	gnomAD
rs2128710983 COSM126912	398	S>*	upper_aerodigestive_tract [Cosmic]	No	cosmic curated Ensembl
rs2128710983	398	S>L		No	Ensembl
rs2128710993	398	S>P		No	Ensembl
rs2128710993	398	S>T		No	Ensembl
rs2128710965	399	N>I		No	Ensembl
rs2128710950	399	N>K		No	Ensembl
rs1371504833	400	I>F		No	TOPMed gnomAD
rs1002056236	400	I>M		No	TOPMed gnomAD
rs1371504833	400	I>V		No	TOPMed gnomAD
rs775340905	401	E>*		No	ExAC TOPMed gnomAD
rs2128710911	401	E>D		No	Ensembl
rs1265449575	401	E>G		No	TOPMed gnomAD
rs775340905	401	E>K		No	ExAC TOPMed gnomAD
rs775340905	401	E>Q		No	ExAC TOPMed gnomAD
rs1307627482 COSM1697839 COSM1697840	402	E>K	Variant assessed as Somatic; MODERATE impact. skin [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
rs1307627482	402	E>Q		No	Ensembl
rs2128710897	403	I>F		No	Ensembl
rs2128710891	403	I>N		No	Ensembl
rs2128710897	403	I>V		No	Ensembl
rs1582832402	404	T>I		No	Ensembl
rs1197436960	404	T>P		No	gnomAD
rs1197436960	404	T>S		No	gnomAD
rs1582832402	404	T>S		No	Ensembl
rs2128710858	405	P>A		No	Ensembl
rs2128710847	405	P>L		No	Ensembl
rs2128710858	405	P>S		No	Ensembl
rs2128710858	405	P>T		No	Ensembl
rs1048953715	406	P>A		No	Ensembl
rs1199787368	406	P>H		No	TOPMed gnomAD
rs1199787368	406	P>L		No	TOPMed gnomAD
rs1199787368	406	P>R		No	TOPMed gnomAD
rs1048953715	406	P>S		No	Ensembl
rs1048953715	406	P>T		No	Ensembl
rs1291270003	407	S>C		No	gnomAD
rs1291270003	407	S>F		No	gnomAD
rs1773213262	407	S>P		No	Ensembl
rs1773213262	407	S>T		No	Ensembl
rs1466737621	408	I>F		No	Ensembl
rs2128710794	408	I>N		No	Ensembl
rs1466737621	408	I>V		No	Ensembl
rs1773212536	409	S>C		No	Ensembl
rs1773212307	409	S>R		No	TOPMed
rs2128710777	409	S>T		No	Ensembl
rs2128710765	410	A>G		No	Ensembl
rs745334216	410	A>S		No	ExAC gnomAD
rs745334216	410	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2128710765	410	A>V		No	Ensembl
rs781629779	411	P>A		No	ExAC gnomAD
rs2128710740	411	P>H		No	Ensembl
rs2128710740	411	P>L		No	Ensembl
rs781629779	411	P>S		No	ExAC gnomAD
rs781629779	411	P>T		No	ExAC gnomAD
rs2128710725	412	Q>E		No	Ensembl
rs2128710711	414	I>F		No	Ensembl
TCGA novel	414	I>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs770589705	414	I>S		No	ExAC TOPMed gnomAD
rs770589705	414	I>T		No	ExAC TOPMed gnomAD
rs2128710711	414	I>V		No	Ensembl
rs2128710683	415	V>E		No	Ensembl
rs2128710683	415	V>G		No	Ensembl
rs2128710688	415	V>L		No	Ensembl
rs2128710688	415	V>M		No	Ensembl
rs1773210564	416	A>P		No	TOPMed
rs1773210564	416	A>S		No	TOPMed
rs1773210564	416	A>T		No	TOPMed
rs1217639125	416	A>V		No	gnomAD
rs767322079	417	D>E		No	Ensembl
rs748963951	417	D>G		No	ExAC gnomAD
rs2128710632	417	D>H		No	Ensembl
rs2128710632	417	D>N		No	Ensembl
rs2128710604	418	S>*		No	Ensembl
rs2128710604	418	S>L		No	Ensembl
rs2128710610	418	S>T		No	Ensembl
rs2128710575	419	Y>*		No	Ensembl
rs1279524577 COSM1440096 COSM1440097	419	Y>C	large_intestine [Cosmic]	No	cosmic curated TOPMed gnomAD
COSM1642836 COSM1642835 VAR_041447 COSM20591 rs1444274116	419	Y>H	stomach a gastric adenocarcinoma sample; somatic mutation [Cosmic, UniProt]	No	cosmic curated UniProt TOPMed dbSNP gnomAD
rs1444274116	419	Y>N		No	TOPMed gnomAD
rs2128710560	420	N>K		No	Ensembl
rs1433758459	420	N>S		No	gnomAD
rs778189552	421	G>A		No	ExAC gnomAD
rs778189552	421	G>E		No	ExAC gnomAD
rs1773208837	421	G>R		No	Ensembl
rs778189552	421	G>V		No	ExAC gnomAD
rs1773208837 COSM1672710 COSM1672711	421	G>W	lung [Cosmic]	No	cosmic curated Ensembl
rs1239577422	422	Y>C		No	TOPMed gnomAD
rs1459389274	422	Y>D		No	TOPMed gnomAD
rs1459389274	422	Y>H		No	TOPMed gnomAD
rs752178140	423	V>A		No	ExAC TOPMed gnomAD
rs752178140	423	V>D		No	ExAC TOPMed gnomAD
rs1255187618	423	V>I		No	TOPMed gnomAD
rs867465351	425	Y>C		No	gnomAD
rs1270487763	426	L>F		No	TOPMed gnomAD
rs1270487763	426	L>V		No	TOPMed gnomAD
COSM4785356 COSM1440095	428	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	432	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1205023293	433	R>I		No	TOPMed
rs758345543	433	R>S		No	ExAC TOPMed gnomAD
rs2128705483	434	A>E		No	Ensembl
rs2128705483	434	A>V		No	Ensembl
rs1582823740	435	D>A		No	Ensembl
rs1772909704	435	D>H		No	Ensembl
rs2128705461	436	L>F		No	Ensembl
rs2128705457 COSM1697837 COSM1697838	437	P>L	skin [Cosmic]	No	cosmic curated Ensembl
rs2128705445	438	V>I		No	Ensembl
rs1447587100	439	P>Q		No	gnomAD
rs1447587100	439	P>R		No	gnomAD
rs2128705440	439	P>S		No	Ensembl
COSM141179 rs1582823688	440	S>F	upper_aerodigestive_tract [Cosmic]	No	cosmic curated Ensembl
rs1772908692	440	S>P		No	TOPMed
rs762072029	441	G>A		No	ExAC gnomAD
rs762072029	441	G>V		No	ExAC gnomAD
rs767371570	442	R>Q		No	ExAC TOPMed gnomAD
rs139256509	442	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1287758562	443	C>F		No	TOPMed gnomAD
rs1287758562	443	C>Y		No	TOPMed gnomAD
rs2128705374	444	A>S		No	Ensembl
rs1225522207	444	A>V		No	gnomAD
rs267600781	445	E>K		No	Ensembl
rs759459909	446	A>S		No	ExAC TOPMed gnomAD
rs2128705355	446	A>V		No	Ensembl
rs1772905218	447	V>M		No	TOPMed
rs766342599	448	R>C		No	ExAC TOPMed gnomAD
COSM3857813 COSM3857814 rs766342599	448	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC TOPMed gnomAD
rs374934137	448	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA gnomAD
rs769545143	449	I>T		No	ExAC TOPMed gnomAD
rs772798392	449	I>V		No	ExAC TOPMed gnomAD
rs2128705312	451	E>*		No	Ensembl
rs536309296	451	E>V		No	1000Genomes
rs1365333105	452	S>G		No	TOPMed gnomAD
rs777130376	452	S>N		No	ExAC TOPMed gnomAD
rs747412076	453	C>*		No	ExAC TOPMed gnomAD
rs769199680	453	C>G		No	ExAC gnomAD
rs2128705276	453	C>Y		No	Ensembl
rs1305515541	454	T>A		No	TOPMed gnomAD
rs780387866	454	T>M		No	ExAC TOPMed gnomAD
rs2128705244	456	K>N		No	Ensembl
rs1380119686	457	D>G		No	gnomAD
rs779093341	459	A>E		No	ExAC gnomAD
rs779093341	459	A>G		No	ExAC gnomAD
rs41291920	459	A>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs41291920	459	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs779093341	459	A>V		No	ExAC gnomAD
rs200988886	460	I>M		No	ExAC TOPMed gnomAD
rs754120533	460	I>N		No	ExAC gnomAD
rs754120533	460	I>T		No	ExAC gnomAD
rs1446220228	460	I>V		No	Ensembl
RCV000972430 rs61729671	461	K>E		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs766174223	462	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs751398495	462	P>S		No	ExAC gnomAD
rs751398495	462	P>T		No	ExAC gnomAD
rs986620798	463	Q>*		No	TOPMed gnomAD
rs986620798	463	Q>K		No	TOPMed gnomAD
rs1189662520	463	Q>R		No	TOPMed gnomAD
rs1476515066	464	A>S		No	TOPMed gnomAD
rs1476515066	464	A>T		No	TOPMed gnomAD
rs762992489	465	K>T		No	ExAC gnomAD
rs370199384	466	R>*		No	ESP ExAC TOPMed gnomAD
COSM1072614 rs140178288 COSM4393980 COSM1072612	466	R>Q	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs768456216	467	I>T		No	ExAC gnomAD
COSM3619907 COSM3619906	468	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1772894906	468	I>N		No	Ensembl
rs1292213271	469	Y>C		No	gnomAD
rs2128705105 TCGA novel	470	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs747288191	471	N>I		No	ExAC TOPMed gnomAD
rs747288191	471	N>S		No	ExAC TOPMed gnomAD
rs747288191	471	N>T		No	ExAC TOPMed gnomAD
rs775973005	472	D>G		No	ExAC TOPMed gnomAD
rs2128705083	472	D>H		No	Ensembl
rs2128705083	472	D>Y		No	Ensembl
rs1772892852	473	T>A		No	Ensembl
rs2128705062	473	T>I		No	Ensembl
rs2128705051	474	A>S		No	Ensembl
rs2128705051	474	A>T		No	Ensembl
rs2128705043	474	A>V		No	Ensembl
rs1384775761	475	Q>E		No	TOPMed
rs1384775761	475	Q>K		No	TOPMed
TCGA novel	475	Q>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1772892350	476	V>F		No	Ensembl
rs574409648	476	V>G		No	TOPMed gnomAD
rs1772892350	476	V>I		No	Ensembl
rs550021694	477	F>L		No	1000Genomes gnomAD
rs199884555	478	M>T		No	1000Genomes ExAC TOPMed gnomAD
rs1772891224	479	S>A		No	TOPMed
TCGA novel	479	S>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs778955018	480	T>I		No	ExAC gnomAD
rs746458448	480	T>S		No	ExAC TOPMed gnomAD
rs757273336	482	L>M		No	ExAC gnomAD
rs894014003	483	D>G		No	Ensembl
rs2128704971	483	D>H		No	Ensembl
rs2128704971	483	D>N		No	Ensembl
rs894014003	483	D>V		No	Ensembl
rs1772889433	484	G>D		No	Ensembl
rs1772889433	484	G>V		No	Ensembl
rs1772888531	485	S>C		No	Ensembl
rs1772888531	485	S>F		No	Ensembl
rs1422557855	485	S>P		No	TOPMed gnomAD
rs1772887946	486	A>P		No	gnomAD
rs1772887946	486	A>S		No	gnomAD
rs1772887946	486	A>T		No	gnomAD
rs749377024	486	A>V		No	ExAC TOPMed gnomAD
rs2128704908	487	S>F		No	Ensembl
rs1772886917	488	H>Q		No	Ensembl
rs777928809	488	H>R		No	ExAC TOPMed gnomAD
rs1772887445	488	H>Y		No	Ensembl
rs2128704876	489	L>F		No	Ensembl
rs1190556321	489	L>P		No	gnomAD
rs1772886439	491	L>P		No	TOPMed
rs2128704838	492	P>L		No	Ensembl
rs2128704845	492	P>S		No	Ensembl
COSM3619905 COSM3619904 rs756348072	493	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs146130970	493	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs146130970	493	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs756348072	493	R>S		No	ExAC TOPMed gnomAD
rs1380069762	494	I>L		No	TOPMed
rs2128704811	494	I>N		No	Ensembl
rs766232395	495	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs766232395	495	P>R		No	ExAC TOPMed gnomAD
rs2128704803	495	P>S		No	Ensembl
rs981528087	496	F>L		No	TOPMed gnomAD
rs2128704783	497	A>V		No	Ensembl
rs758263799	498	D>G		No	ExAC gnomAD
rs2128704777	498	D>N		No	Ensembl
rs2128704777	498	D>Y		No	Ensembl
rs2128704769	499	V>L		No	Ensembl
rs1772883690	500	K>N		No	TOPMed
rs1772883967	500	K>T		No	Ensembl
rs1310552526	501	S>N		No	gnomAD
rs1301103592	502	F>C		No	gnomAD
rs142940626	503	A>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1772882819	503	A>V		No	Ensembl
rs2128704730	505	E>K		No	Ensembl
rs2128704727	506	N>K		No	Ensembl
rs1203305316	507	N>D		No	gnomAD
rs761338135	507	N>I		No	ExAC gnomAD
rs763818587	508	D>E		No	ExAC gnomAD
rs1772881276	508	D>G		No	TOPMed
rs1399068165	508	D>H		No	gnomAD
rs1463033775	509	F>L		No	TOPMed gnomAD
rs1375443218	510	L>F		No	gnomAD
rs2128704680 COSM1647864 COSM739470 COSM739469	512	T>S	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs1466317364	513	D>E		No	TOPMed gnomAD
rs775717825	513	D>G		No	ExAC gnomAD
rs2128704673	513	D>Y		No	Ensembl
rs1772879507	514	G>D		No	Ensembl
rs2128704655	514	G>S		No	Ensembl
rs201527593	515	K>R		No	Ensembl
rs2128704631	516	V>I		No	Ensembl
rs2128704631	516	V>L		No	Ensembl
rs1396856660	517	I>V		No	gnomAD
rs2128704608	520	Q>*		No	Ensembl
rs2128704601	520	Q>H		No	Ensembl
rs2128704597	521	D>N		No	Ensembl
rs1457175155	521	D>V		No	gnomAD
rs1772877369	522	A>V		No	TOPMed
rs774776316	524	S>C		No	ExAC gnomAD
rs1772877142	524	S>T		No	TOPMed
rs771457051	526	N>I		No	ExAC TOPMed gnomAD
rs771457051	526	N>S		No	ExAC TOPMed gnomAD
rs2128704578	526	N>Y		No	Ensembl
rs1766824259	527	E>*		No	Ensembl
rs749314336	527	E>A		No	ExAC gnomAD
rs1766824259 COSM3619901 COSM1440092 COSM1440093	527	E>K	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic Ensembl
rs1766824259	527	E>Q		No	Ensembl
rs749314336	527	E>V		No	ExAC gnomAD
rs2128704524	528	F>L		No	Ensembl
rs1772875855	529	I>F		No	gnomAD
rs527529345	529	I>M		No	1000Genomes ExAC TOPMed gnomAD
rs1772875855	529	I>V		No	gnomAD
rs878999513	530	V>L		No	Ensembl
rs878999513	530	V>M		No	Ensembl
rs1442991049	531	G>*		No	TOPMed gnomAD
rs1234135807	531	G>E		No	gnomAD
rs1442991049	531	G>R		No	TOPMed gnomAD
rs1234135807	531	G>V		No	gnomAD
rs2128704477	532	C>*		No	Ensembl
rs2128704481	532	C>S		No	Ensembl
rs2128704477	532	C>W		No	Ensembl
rs2128704481	532	C>Y		No	Ensembl
rs2128704466	533	D>E		No	Ensembl
rs2128704473	533	D>H		No	Ensembl
rs2128704470	533	D>V		No	Ensembl
rs2128704473	533	D>Y		No	Ensembl
rs748468509	534	L>M		No	ExAC TOPMed
rs2128704455	534	L>P		No	Ensembl
rs748468509	534	L>V		No	ExAC TOPMed
rs779701008	535	S>C		No	ExAC gnomAD
rs779701008	535	S>G		No	ExAC gnomAD
rs2128704427	535	S>I		No	Ensembl
TCGA novel	535	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128704421	535	S>R		No	Ensembl
rs779701008	535	S>R		No	ExAC gnomAD
rs2128704414	536	H>D		No	Ensembl
rs2128704407	536	H>L		No	Ensembl
rs2128704403	536	H>Q		No	Ensembl
rs2128704407	536	H>R		No	Ensembl
rs2128704414	536	H>Y		No	Ensembl
rs28639589 VAR_041448	537	I>M		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1378148607	537	I>T		No	gnomAD
rs758152077	537	I>V		No	ExAC gnomAD
rs757314497	538	E>A		No	ExAC TOPMed gnomAD
TCGA novel rs2128704369	538	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs778946604	538	E>Q		No	ExAC TOPMed gnomAD
COSM4864797 COSM1072611 rs1772873017 COSM1072609	539	E>*	Variant assessed as Somatic; HIGH impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic Ensembl
rs2128704348	539	E>D		No	Ensembl
rs1772873017	539	E>K		No	Ensembl
rs1772873017	539	E>Q		No	Ensembl
rs1466151077	540	F>L		No	gnomAD
rs1301719041	540	F>S		No	gnomAD
rs753367494	541	G>A		No	ExAC TOPMed gnomAD
rs753367494	541	G>E		No	ExAC TOPMed gnomAD
rs753367494	541	G>V		No	ExAC TOPMed gnomAD
rs760234329	543	G>A		No	ExAC TOPMed gnomAD
rs763765128	543	G>C		No	ExAC TOPMed gnomAD
rs760234329	543	G>D		No	ExAC TOPMed gnomAD
rs763765128	543	G>R		No	ExAC TOPMed gnomAD
rs763765128	543	G>S		No	ExAC TOPMed gnomAD
rs760234329	543	G>V		No	ExAC TOPMed gnomAD
rs752340723	544	N>S		No	ExAC gnomAD
rs2128704295	545	L>F		No	Ensembl
rs991227380	545	L>S		No	Ensembl
rs767083171	546	V>A		No	ExAC TOPMed gnomAD
rs767083171	546	V>D		No	ExAC TOPMed gnomAD
rs2128704286	546	V>F		No	Ensembl
rs2128704286	546	V>I		No	Ensembl
rs2128704286	546	V>L		No	Ensembl
rs1772869943	547	I>F		No	TOPMed
rs149258740	547	I>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128704264	547	I>T		No	Ensembl
rs1772869943	547	I>V		No	TOPMed
rs2128704251	548	F>I		No	Ensembl
rs762731566	548	F>L		No	ExAC TOPMed gnomAD
rs556303105	548	F>S		No	1000Genomes
rs2128704228	549	G>A		No	Ensembl
rs1298125194	549	G>C		No	gnomAD
rs2128704228	549	G>D		No	Ensembl
rs1298125194	549	G>R		No	gnomAD
rs1298125194	549	G>S		No	gnomAD
rs2128704228	549	G>V		No	Ensembl
rs763487146	550	S>*		No	ExAC TOPMed gnomAD
rs763487146	550	S>L		No	ExAC TOPMed gnomAD
rs2128704214	550	S>P		No	Ensembl
rs2128704214	550	S>T		No	Ensembl
rs865940125	551	S>C		No	Ensembl
rs865940125 COSM450403 COSM450404 COSM3157880	551	S>F	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
rs2128704195	551	S>P		No	Ensembl
rs773272241	552	S>A		No	ExAC gnomAD
rs769974183	552	S>C		No	ExAC gnomAD
rs769974183	552	S>F		No	ExAC gnomAD
rs773272241	552	S>P		No	ExAC gnomAD
rs748189554	553	Q>*		No	ExAC gnomAD
rs748189554	553	Q>E		No	ExAC gnomAD
rs2128704148	553	Q>H		No	Ensembl
rs748189554	553	Q>K		No	ExAC gnomAD
rs2128704156	553	Q>L		No	Ensembl
rs2128704139	554	L>M		No	Ensembl
rs2128704130	554	L>P		No	Ensembl
rs2128704130	554	L>Q		No	Ensembl
rs2128704139	554	L>V		No	Ensembl
rs2128704120	555	H>D		No	Ensembl
rs2128704110	555	H>L		No	Ensembl
rs2128704110	555	H>P		No	Ensembl
rs2128704104	555	H>Q		No	Ensembl
rs2128704110	555	H>R		No	Ensembl
rs2128704120	555	H>Y		No	Ensembl
rs2128704099	556	P>A		No	Ensembl
rs2128704087	556	P>H		No	Ensembl
rs2128704087	556	P>L		No	Ensembl
rs2128704087	556	P>R		No	Ensembl
rs2128704099	556	P>S		No	Ensembl
rs2128704075 TCGA novel	557	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128704056	558	P>A		No	Ensembl
rs2128704044	558	P>L		No	Ensembl
rs2128704044	558	P>R		No	Ensembl
rs2128704056	558	P>S		No	Ensembl
rs2128704008	559	G>A		No	Ensembl
rs2128704008	559	G>D		No	Ensembl
rs2128704025	559	G>R		No	Ensembl
rs2128704025	559	G>S		No	Ensembl
rs2128704008	559	G>V		No	Ensembl
COSM95211 rs768790336	560	R>C	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs768790336	560	R>G		No	ExAC TOPMed gnomAD
rs145765584	560	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs145765584	560	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs145765584	560	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128703960	561	P>A		No	Ensembl
COSM421102 COSM4811787 COSM421101 rs199766618	561	P>L	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs199766618	561	P>Q		No	1000Genomes ExAC TOPMed gnomAD
rs199766618	561	P>R		No	1000Genomes ExAC TOPMed gnomAD
rs2128703960	561	P>S		No	Ensembl
rs2128703960	561	P>T		No	Ensembl
rs2128703929	562	Q>E		No	Ensembl
rs2128703911	562	Q>H		No	Ensembl
rs2128703923	562	Q>L		No	Ensembl
rs1772865085	563	E>D		No	gnomAD
rs2128703885	563	E>K		No	Ensembl
rs2128703885	563	E>Q		No	Ensembl
rs2128703878	563	E>V		No	Ensembl
rs1414828115	564	L>F		No	TOPMed gnomAD
rs2128703842	564	L>H		No	Ensembl
rs1414828115	564	L>I		No	TOPMed gnomAD
rs2128703842	564	L>P		No	Ensembl
rs1414828115	564	L>V		No	TOPMed gnomAD
rs142303126	565	S>L		No	ESP ExAC TOPMed gnomAD
rs142303126	565	S>W		No	ESP ExAC TOPMed gnomAD
rs2128703809	566	V>E		No	Ensembl
rs752182904	566	V>L		No	ExAC gnomAD
rs752182904	566	V>M		No	ExAC gnomAD
rs1772862569	567	L>P		No	Ensembl
rs372925583	567	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1262579913	568	F>S		No	TOPMed gnomAD
rs1262579913	568	F>Y		No	TOPMed gnomAD
rs2128703765	569	G>A		No	Ensembl
rs2128703765	569	G>D		No	Ensembl
rs2128703775	569	G>S		No	Ensembl
rs2128703765	569	G>V		No	Ensembl
rs751886816	570	S>F		No	ExAC gnomAD
rs1011035461	570	S>P		No	TOPMed gnomAD
rs1011035461	570	S>T		No	TOPMed gnomAD
rs2128703729	571	H>L		No	Ensembl
rs1052612678	571	H>N		No	Ensembl
rs2128703724	571	H>Q		No	Ensembl
rs1052612678	571	H>Y		No	Ensembl
rs976221573	572	Q>*		No	TOPMed gnomAD
rs2128703711	572	Q>H		No	Ensembl
rs976221573	572	Q>K		No	TOPMed gnomAD
rs2128703700	573	A>P		No	Ensembl
rs2128703700	573	A>S		No	Ensembl
rs2128703700	573	A>T		No	Ensembl
rs2128703693	573	A>V		No	Ensembl
rs2128703670	574	L>H		No	Ensembl
rs2128703670	574	L>P		No	Ensembl
rs2128703680	574	L>V		No	Ensembl
rs2128703655	575	V>D		No	Ensembl
rs2128703655	575	V>G		No	Ensembl
rs2128703660	575	V>I		No	Ensembl
rs2128703660	575	V>L		No	Ensembl
COSM3157873 COSM3157872 rs2128703641	576	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128703641	576	Q>E		No	Ensembl
rs2128703607	577	W>*		No	Ensembl
rs2128703615	577	W>*		No	Ensembl
rs2128703607	577	W>C		No	Ensembl
rs1582821593	577	W>G		No	Ensembl
rs2128703615	577	W>L		No	Ensembl
rs1582821593	577	W>R		No	Ensembl
rs2128703615	577	W>S		No	Ensembl
rs2128703602	578	K>*		No	Ensembl
rs2128703595	578	K>N		No	Ensembl
rs1261108140	579	P>A		No	gnomAD
rs2128703587	579	P>L		No	Ensembl
rs1261108140	579	P>S		No	gnomAD
rs1772858237	580	P>A		No	Ensembl
rs2128703570	580	P>L		No	Ensembl
rs1772858237	580	P>S		No	Ensembl
rs267600780	581	A>D		No	TOPMed gnomAD
rs773651108	581	A>P		No	ExAC gnomAD
rs773651108	581	A>S		No	ExAC gnomAD
rs773651108	581	A>T		No	ExAC gnomAD
rs267600780	581	A>V		No	TOPMed gnomAD
rs2128703550	582	L>F		No	Ensembl
rs1582821484	582	L>P		No	Ensembl
rs2128703550	582	L>V		No	Ensembl
rs1264432555	583	A>D		No	gnomAD
rs1264432555	583	A>G		No	gnomAD
rs761911387	583	A>P		No	ExAC TOPMed gnomAD
rs761911387	583	A>S		No	ExAC TOPMed gnomAD
rs761911387	583	A>T		No	ExAC TOPMed gnomAD
rs1264432555	583	A>V		No	gnomAD
rs776624648	584	I>K		No	ExAC TOPMed gnomAD
rs2128703511	584	I>L		No	Ensembl
rs1772855734	585	G>*		No	gnomAD
rs2128703495	585	G>A		No	Ensembl
rs2128703495	585	G>E		No	Ensembl
rs1772855734	585	G>R		No	gnomAD
rs747302749	586	A>D		No	ExAC TOPMed gnomAD
rs747302749	586	A>G		No	ExAC TOPMed gnomAD
rs747302749	586	A>V		No	ExAC TOPMed gnomAD
rs185334662	587	N>S		No	1000Genomes ExAC TOPMed gnomAD
rs185334662	587	N>T		No	1000Genomes ExAC TOPMed gnomAD
rs2128703466	587	N>Y		No	Ensembl
rs2128701569	588	V>A		No	Ensembl
rs2128701583	588	V>I		No	Ensembl
rs2128701583	588	V>L		No	Ensembl
rs776770495	589	I>F		No	ExAC gnomAD
rs1416061465	589	I>M		No	gnomAD
rs776770495	589	I>V		No	ExAC gnomAD
rs764138686	590	L>P		No	ExAC gnomAD
rs1442896981	591	I>M		No	gnomAD
rs2128701535	591	I>T		No	Ensembl
rs1772736986	591	I>V		No	TOPMed gnomAD
rs2128701525	592	S>C		No	Ensembl
TCGA novel	592	S>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128701521	592	S>N		No	Ensembl
rs1398319876	592	S>R		No	gnomAD
rs2128701498	593	D>E		No	Ensembl
rs1330973277	593	D>N		No	TOPMed gnomAD
rs1330973277	593	D>Y		No	TOPMed gnomAD
rs2128701494	594	I>V		No	Ensembl
rs2128701479	595	I>F		No	Ensembl
rs1772735885	595	I>T		No	Ensembl
rs2128701456	596	E>*		No	Ensembl
rs2128701448	596	E>D		No	Ensembl
COSM450402	596	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128701456	596	E>Q		No	Ensembl
rs2128701452	596	E>V		No	Ensembl
rs775792027	597	L>F		No	ExAC gnomAD
rs775792027	597	L>V		No	ExAC gnomAD
rs749046164	598	F>L		No	ExAC gnomAD
rs2128701421	599	E>A		No	Ensembl
rs1477984030	599	E>D		No	gnomAD
COSM1697835 rs867987684 COSM1697836	599	E>K	Variant assessed as Somatic; MODERATE impact. skin [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
rs2128701421	599	E>V		No	Ensembl
COSM4920963 COSM4920964	600	L>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128701409	600	L>F		No	Ensembl
rs1772734278	600	L>S		No	TOPMed
rs769737276	601	G>A		No	ExAC gnomAD
rs2128701401	601	G>C		No	Ensembl
rs769737276	601	G>D		No	ExAC gnomAD
rs2128701401	601	G>R		No	Ensembl
rs2128701401	601	G>S		No	Ensembl
rs769737276	601	G>V		No	ExAC gnomAD
rs1438247113	602	P>A		No	gnomAD
rs2128701365	602	P>H		No	Ensembl
rs2128701365	602	P>L		No	Ensembl
rs2128701365	602	P>R		No	Ensembl
rs1438247113	602	P>S		No	gnomAD
rs1235934351	603	S>A		No	TOPMed gnomAD
rs1713882489	603	S>C		No	TOPMed
rs1713882489	603	S>F		No	TOPMed
rs780736075	604	A>G		No	ExAC gnomAD
rs1772732533	604	A>P		No	Ensembl
rs1772732533	604	A>S		No	Ensembl
rs1772732533	604	A>T		No	Ensembl
rs780736075	604	A>V		No	ExAC gnomAD
rs2128701291	605	W>*		No	Ensembl
rs2128701303	605	W>*		No	Ensembl
rs2128701291	605	W>C		No	Ensembl
rs2128701309	605	W>R		No	Ensembl
rs2128701303	605	W>S		No	Ensembl
rs2128701283	606	Q>H		No	Ensembl
rs2128701278	607	N>D		No	Ensembl
rs2128701271	607	N>K		No	Ensembl
rs2128701278	607	N>Y		No	Ensembl
rs779640008	608	W>*		No	ExAC TOPMed gnomAD
rs1772730824	608	W>*		No	Ensembl
rs1772730824	608	W>C		No	Ensembl
rs779640008	608	W>L		No	ExAC TOPMed gnomAD
rs376165477	608	W>R		No	ESP ExAC TOPMed gnomAD
rs779640008	608	W>S		No	ExAC TOPMed gnomAD
rs2128701235	609	T>I		No	Ensembl
rs2128701242	609	T>P		No	Ensembl
rs2128701235	609	T>S		No	Ensembl
rs750770442	610	Y>C		No	ExAC gnomAD
rs750770442	610	Y>F		No	ExAC gnomAD
rs2128701216	610	Y>N		No	Ensembl
rs1465868712	611	E>D		No	TOPMed gnomAD
rs2128701201	611	E>G		No	Ensembl
rs2128701204	611	E>K		No	Ensembl
rs2128701204	611	E>Q		No	Ensembl
rs2128701201	611	E>V		No	Ensembl
rs2128701172	612	V>E		No	Ensembl
rs1357720968	612	V>L		No	gnomAD
rs779213880	613	K>E		No	ExAC gnomAD
COSM1647865 COSM739472 COSM739471 rs1582817966	614	V>A	lung [Cosmic]	No	cosmic curated Ensembl
rs1582817966	614	V>E		No	Ensembl
rs1582817966	614	V>G		No	Ensembl
TCGA novel	614	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs757769588	615	S>A		No	ExAC gnomAD
rs188607208	615	S>C		No	1000Genomes ExAC TOPMed gnomAD
rs188607208	615	S>F		No	1000Genomes ExAC TOPMed gnomAD
rs188607208	615	S>Y		No	1000Genomes ExAC TOPMed gnomAD
rs764706003	616	T>I		No	ExAC TOPMed gnomAD
rs764706003	616	T>S		No	ExAC TOPMed gnomAD
rs950724665	617	Q>*		No	TOPMed gnomAD
rs950724665	617	Q>E		No	TOPMed gnomAD
rs752848792	617	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs950724665	617	Q>K		No	TOPMed gnomAD
rs1178195749	618	D>E		No	gnomAD
rs151183861 RCV000897120	618	D>G		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1438145481	618	D>H		No	TOPMed gnomAD
rs1438145481	618	D>N		No	TOPMed gnomAD
rs151183861	618	D>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1438145481	618	D>Y		No	TOPMed gnomAD
rs1470291308	619	P>A		No	gnomAD
rs1772725760	619	P>H		No	gnomAD
rs1772725760	619	P>L		No	gnomAD
rs1772725760	619	P>R		No	gnomAD
rs1470291308	619	P>S		No	gnomAD
rs1234303360	620	P>A		No	TOPMed gnomAD
rs2128701016	620	P>L		No	Ensembl
rs2128701016	620	P>R		No	Ensembl
rs1234303360	620	P>S		No	TOPMed gnomAD
rs2128700988	621	E>D		No	Ensembl
COSM3619895 rs759714879 COSM3619896	621	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs759714879	621	E>Q		No	ExAC gnomAD
rs2128700994	621	E>V		No	Ensembl
rs2128700970	622	V>D		No	Ensembl
rs2128700975	622	V>F		No	Ensembl
rs2128700970	622	V>G		No	Ensembl
TCGA novel	622	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128700975	622	V>L		No	Ensembl
rs1562349493	623	T>I		No	Ensembl
rs1562349493	623	T>S		No	Ensembl
rs1562349506	623	T>S		No	Ensembl
rs773053104	623	T>S		No	ExAC TOPMed gnomAD
rs2128700936	624	H>D		No	Ensembl
rs2128700936	624	H>N		No	Ensembl
rs2128700929	624	H>Q		No	Ensembl
rs769530508	624	H>R		No	ExAC TOPMed gnomAD
rs2128700936 TCGA novel	624	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128700922	625	I>F		No	Ensembl
rs1280879862	625	I>N		No	gnomAD
rs1280879862	625	I>T		No	gnomAD
rs2128700899	626	F>I		No	Ensembl
rs776365305	626	F>L		No	ExAC
rs2128700897	626	F>Y		No	Ensembl
rs2128700888	627	L>*		No	Ensembl
rs2128700879	628	N>I		No	Ensembl
rs2128700872	628	N>K		No	Ensembl
rs2128700885	628	N>Y		No	Ensembl
rs1285043088	629	I>T		No	gnomAD
rs142877218	629	I>V		No	ESP ExAC TOPMed gnomAD
rs1772722306	630	S>G		No	Ensembl
rs1224165751	630	S>N		No	TOPMed gnomAD
rs2128700851	630	S>R		No	Ensembl
rs1224165751	630	S>T		No	TOPMed gnomAD
rs1282664597	631	G>E		No	gnomAD
rs1375767478	631	G>R		No	TOPMed gnomAD
rs148952125	632	T>I		No	ESP ExAC TOPMed gnomAD
rs148952125	632	T>N		No	ESP ExAC TOPMed gnomAD
rs148952125	632	T>S		No	ESP ExAC TOPMed gnomAD
rs2128700805	633	M>I		No	Ensembl
rs2128700815	633	M>K		No	Ensembl
rs373150912	633	M>V		No	ESP TOPMed gnomAD
TCGA novel	634	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128700789	634	L>Q		No	Ensembl
rs2128700797	634	L>V		No	Ensembl
rs1418393917	635	N>D		No	gnomAD
rs2128700760	635	N>K		No	Ensembl
rs2128700765	635	N>S		No	Ensembl
rs2128700741	636	V>E		No	Ensembl
rs146800947	636	V>I		No	ESP ExAC TOPMed gnomAD
rs146800947	636	V>L		No	ESP ExAC TOPMed gnomAD
rs2128700718	637	P>A		No	Ensembl
rs2128700706	637	P>H		No	Ensembl
rs2128700706	637	P>R		No	Ensembl
rs2128700718	637	P>S		No	Ensembl
rs190237500	638	E>D		No	1000Genomes TOPMed
rs2128700682	638	E>G		No	Ensembl
rs745567393	638	E>K		No	ExAC TOPMed gnomAD
rs745567393	638	E>Q		No	ExAC TOPMed gnomAD
rs2128700682	638	E>V		No	Ensembl
rs2128700667	639	L>Q		No	Ensembl
rs2128700670	639	L>V		No	Ensembl
rs2128700650	640	Q>*		No	Ensembl
rs2128700650	640	Q>E		No	Ensembl
rs757498661	640	Q>H		No	ExAC gnomAD
rs1772718414	640	Q>L		No	Ensembl
rs1772718414	640	Q>P		No	Ensembl
rs1772718414	640	Q>R		No	Ensembl
rs2128700628	641	S>I		No	Ensembl
rs2128700621	641	S>R		No	Ensembl
rs2128700609	642	A>G		No	Ensembl
rs2128700616	642	A>S		No	Ensembl
rs2128700616	642	A>T		No	Ensembl
rs2128700609	642	A>V		No	Ensembl
rs1772717502	643	M>I		No	TOPMed
rs2128700593	643	M>K		No	Ensembl
rs1772717785	643	M>V		No	Ensembl
rs2128700569	645	Y>*		No	Ensembl
rs1772717255	645	Y>C		No	TOPMed
rs1772717255	645	Y>F		No	TOPMed
rs2128700581	645	Y>N		No	Ensembl
rs2128700560	646	K>E		No	Ensembl
rs2128700550	646	K>M		No	Ensembl
rs1257591659	646	K>N		No	gnomAD
rs2128700550	646	K>R		No	Ensembl
rs1189533164	647	V>G		No	gnomAD
rs2128700541	647	V>L		No	Ensembl
rs754263972	648	S>C		No	ExAC TOPMed gnomAD
rs754263972	648	S>F		No	ExAC TOPMed gnomAD
rs2128700506	649	V>E		No	Ensembl
rs2128700512	649	V>L		No	Ensembl
rs2128700512	649	V>M		No	Ensembl
rs756738703	650	R>*		No	ExAC gnomAD
rs991348240	650	R>T		No	Ensembl
rs1287908780	651	A>E		No	gnomAD
rs1287908780	651	A>G		No	gnomAD
rs959532375	651	A>S		No	TOPMed gnomAD
rs959532375	651	A>T		No	TOPMed gnomAD
rs752789600	652	S>I		No	ExAC gnomAD
rs752789600	652	S>N		No	ExAC gnomAD
rs767768845	652	S>R		No	ExAC gnomAD
VAR_041449 RCV000883933 rs34203286	653	S>F		No	ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2128700458	653	S>T		No	Ensembl
rs2128700440	654	P>Q		No	Ensembl
rs768882618	654	P>S		No	ExAC TOPMed gnomAD
rs1290003301	655	K>E		No	gnomAD
rs1463259574	655	K>N		No	TOPMed
rs766626912	655	K>R		No	ExAC TOPMed gnomAD
rs950981570	656	R>S		No	gnomAD
rs1668481562	657	P>R		No	TOPMed
rs2128700412	657	P>S		No	Ensembl
rs755395111	658	G>D		No	Ensembl
rs1025709504 COSM3619890 COSM3619889	658	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs2128700390	659	P>A		No	Ensembl
rs1772711497	659	P>L		No	TOPMed
rs993831048	660	W>*		No	Ensembl
rs2128700369	660	W>L		No	Ensembl
rs1772710525	661	S>*		No	TOPMed
rs1772710525	661	S>L		No	TOPMed
rs9489143	662	E>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1234660715	663	P>S		No	gnomAD
rs1234660715	663	P>T		No	gnomAD
rs1166433247	664	S>L		No	gnomAD
TCGA novel	665	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs776432501	666	G>D		No	ExAC gnomAD
rs1772709248	666	G>S		No	gnomAD
rs776432501	666	G>V		No	ExAC gnomAD
rs1772708278	667	T>I		No	Ensembl
rs768558296	668	T>A		No	ExAC TOPMed gnomAD
rs2128700244	671	P>A		No	Ensembl
rs2128700244	671	P>S		No	Ensembl
rs1197748682	672	A>D		No	TOPMed gnomAD
rs1197748682	672	A>V		No	TOPMed gnomAD
rs767522283	674	E>K		No	ExAC gnomAD
rs2128698834	675	P>S		No	Ensembl
rs1455451657	676	P>Q		No	TOPMed gnomAD
rs2128698815	679	M>T		No	Ensembl
rs1772635464	679	M>V		No	gnomAD
TCGA novel	680	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128698805	680	A>V		No	Ensembl
rs200174940	681	V>G		No	gnomAD
rs1298220220	681	V>M		No	gnomAD
rs78135931	682	K>E		No	Ensembl
COSM1072605 COSM4865496	682	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3619885 COSM3619886	682	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1772634109	684	D>G		No	Ensembl
rs1772634374	684	D>N		No	TOPMed
rs773963225	685	G>E		No	ExAC gnomAD
rs758924871	685	G>R		No	ExAC TOPMed gnomAD
rs770462582	686	L>F		No	ExAC gnomAD
rs986408020	688	S>C		No	Ensembl
rs749011714	688	S>N		No	ExAC TOPMed gnomAD
rs1772631970	688	S>R		No	TOPMed
rs924678775	690	P>A		No	TOPMed gnomAD
rs1418694067	690	P>L		No	gnomAD
rs924678775	690	P>S		No	TOPMed gnomAD
rs924678775	690	P>T		No	TOPMed gnomAD
rs773694464	691	L>S		No	ExAC TOPMed gnomAD
rs770223989	692	N>D		No	ExAC gnomAD
rs748525048	694	F>S		No	ExAC gnomAD
rs2128698647	695	G>V		No	Ensembl
rs144476736	696	P>A		No	ESP ExAC TOPMed gnomAD
rs756401492	696	P>L		No	Ensembl
rs1350752092	697	G>A		No	gnomAD
rs1350752092	697	G>E		No	gnomAD
rs139359697	698	E>K		No	ESP ExAC TOPMed gnomAD
rs1772628057	699	F>V		No	gnomAD
rs1021788151	699	F>Y		No	TOPMed gnomAD
rs747038362	700	L>S		No	ExAC gnomAD
rs150866859	701	S>P		No	ESP TOPMed gnomAD
rs150866859	701	S>T		No	ESP TOPMed gnomAD
rs979171969	703	D>V		No	Ensembl
rs758536297	704	I>T		No	ExAC TOPMed gnomAD
rs1307288773	704	I>V		No	TOPMed gnomAD
COSM1722624 rs868430526 COSM1722625	705	G>E	NS [Cosmic]	No	cosmic curated Ensembl
rs2128698546	709	D>N		No	Ensembl
rs772072753	710	M>T		No	ExAC TOPMed gnomAD
rs148214833	710	M>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1443464945	711	D>G		No	TOPMed gnomAD
rs745980825 COSM1647867 COSM739476	711	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs779059461	713	Y>C		No	ExAC TOPMed gnomAD
COSM4783165 COSM1440088 COSM1440087 rs779059461	713	Y>F	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC TOPMed gnomAD
rs1237169331	714	N>K		No	TOPMed
rs868736129	714	N>S		No	TOPMed gnomAD
rs1281615431	715	N>D		No	TOPMed
rs1582811825	715	N>T		No	Ensembl
rs1044819500	716	S>N		No	Ensembl
rs752460038	716	S>R		No	ExAC gnomAD
rs2128696952	717	L>F		No	Ensembl
rs1336317487 COSM1072600 COSM4866065 COSM1072602	718	Y>*	Variant assessed as Somatic; HIGH impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1772532255	719	Y>C		No	TOPMed
rs781112268	719	Y>D		No	ExAC gnomAD
rs754861620	720	S>G		No	ExAC gnomAD
rs1656690011	721	D>N		No	TOPMed
COSM4435153 rs372637439 COSM4435152	722	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs1192547872	723	K>I		No	TOPMed gnomAD
rs2128696887	724	G>C		No	Ensembl
rs368540212	725	D>E		No	ESP ExAC TOPMed gnomAD
rs764959275	725	D>H		No	ExAC TOPMed gnomAD
rs764959275 COSM277105 COSM3157852 COSM277104	725	D>N	kidney Variant assessed as Somatic; MODERATE impact. large_intestine [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs761597558	725	D>V		No	ExAC gnomAD
rs764959275	725	D>Y		No	ExAC TOPMed gnomAD
rs776027945	726	V>F		No	ExAC TOPMed gnomAD
rs776027945 COSM3157851 COSM3157850	726	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs776027945	726	V>L		No	ExAC TOPMed gnomAD
COSM95209 rs1476008353	727	F>S	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1166225687	729	W>C		No	TOPMed gnomAD
rs1772527807	729	W>L		No	TOPMed
rs199693780	731	L>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1197137422	731	L>P		No	gnomAD
rs199693780	731	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1772525882	733	G>E		No	gnomAD
COSM3619884 COSM3619883 rs745928815	733	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1772525882	733	G>V		No	gnomAD
rs779006477	734	T>M		No	ExAC TOPMed gnomAD
rs779006477	734	T>R		No	ExAC TOPMed gnomAD
rs575172787	735	D>A		No	1000Genomes ExAC gnomAD
rs2128696696	735	D>E		No	Ensembl
rs575172787	735	D>G		No	1000Genomes ExAC gnomAD
rs1270271107	735	D>N		No	gnomAD
rs1339970861	736	I>N		No	gnomAD
rs2128696666	737	S>*		No	Ensembl
TCGA novel	738	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2128696649 COSM202096 COSM202097	738	E>D	large_intestine [Cosmic]	No	cosmic curated Ensembl
COSM1647869 COSM739480	738	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128696658	738	E>Q		No	Ensembl
rs1231753319	740	Y>*		No	TOPMed gnomAD
rs2128696626	741	H>L		No	Ensembl
rs754731646	741	H>Q		No	ExAC TOPMed gnomAD
rs777867372	741	H>Y		No	ExAC TOPMed gnomAD
COSM4874285 COSM1072599	742	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1772522469	742	L>P		No	TOPMed
rs779989121	743	P>H		No	ExAC TOPMed gnomAD
rs779989121	743	P>L		No	ExAC TOPMed gnomAD
COSM1292191 rs1334242622 COSM1292190	743	P>S	haematopoietic_and_lymphoid_tissue [Cosmic]	No	cosmic curated gnomAD
rs1334242622	743	P>T		No	gnomAD
rs2128696595	744	S>I		No	Ensembl
rs2128696595	744	S>N		No	Ensembl
rs758457911	744	S>R		No	ExAC TOPMed gnomAD
rs749919362	745	I>L		No	ExAC gnomAD
rs764906451	745	I>N		No	ExAC gnomAD
rs764906451	745	I>T		No	ExAC gnomAD
rs1396060666	746	A>S		No	gnomAD
rs1396060666	746	A>T		No	gnomAD
rs2128696560 COSM3619882 COSM3619881	746	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1772520151	747	G>E		No	TOPMed
TCGA novel	748	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs753464937	748	A>V		No	ExAC gnomAD
rs1582811221	749	G>E		No	Ensembl
rs2128696525	750	A>S		No	Ensembl
rs761052833	751	L>F		No	ExAC
rs1772518339	751	L>S		No	gnomAD
rs775768999	754	E>K		No	ExAC gnomAD
rs372359152	755	W>*		No	ESP ExAC gnomAD
rs1328235226	755	W>*		No	TOPMed
rs1328235226	755	W>C		No	TOPMed
rs372359152	755	W>L		No	ESP ExAC gnomAD
rs760105730	755	W>R		No	ExAC
rs1347143996	756	L>V		No	gnomAD
rs773440188	758	H>D		No	ExAC
rs542174827	759	F>L		No	1000Genomes ExAC gnomAD
rs141715386	760	L>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141715386 RCV000968602	760	L>I		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs745858708	760	L>P		No	ExAC gnomAD
rs745858708	760	L>R		No	ExAC gnomAD
rs2128696416	761	Y>*		No	Ensembl
rs1311205624	761	Y>C		No	TOPMed gnomAD
rs1376640341	762	W>L		No	gnomAD
rs761749336	762	W>R		No	ExAC gnomAD
rs1772513586	763	A>D		No	TOPMed
rs1772513586	763	A>G		No	TOPMed
rs2128696396	763	A>T		No	Ensembl
rs1175898010	764	G>*		No	TOPMed gnomAD
rs1175898010	764	G>R		No	TOPMed gnomAD
rs368679172	764	G>V		No	ESP TOPMed
rs147011370	765	K>N		No	ESP TOPMed
rs1405296671	766	T>I		No	TOPMed gnomAD
rs753311379	766	T>S		No	ExAC gnomAD
rs763782411	767	Y>*		No	ExAC TOPMed gnomAD
rs2128696360	767	Y>C		No	Ensembl
rs1010874419	768	V>L		No	gnomAD
rs1562342854	769	I>T		No	Ensembl
rs1562342866	769	I>V		No	Ensembl
rs529695010	770	Q>P		No	1000Genomes ExAC TOPMed gnomAD
rs529695010	770	Q>R		No	1000Genomes ExAC TOPMed gnomAD
rs745689107	772	Q>P		No	ExAC gnomAD
rs778946384	773	S>C		No	ExAC TOPMed gnomAD
rs778946384	773	S>F		No	ExAC TOPMed gnomAD
rs2128693078	774	V>M		No	Ensembl
rs565705980	775	L>V		No	1000Genomes ExAC TOPMed gnomAD
rs149313880	776	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs149313880	776	T>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1772320905	776	T>S		No	TOPMed
rs2128693046	777	G>R		No	Ensembl
rs2128693030	778	H>Q		No	Ensembl
rs2128693042	778	H>Y		No	Ensembl
rs1772320170	779	T>A		No	TOPMed
rs2128693016	779	T>I		No	Ensembl
COSM1496215 COSM1496216 rs201235239	780	D>E	Variant assessed as Somatic; MODERATE impact. kidney [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC gnomAD
rs2128693007	780	D>H		No	Ensembl
COSM3157843 COSM1072596	780	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs767165414	781	I>V		No	ExAC gnomAD
rs1271113755	782	V>A		No	gnomAD
rs1271113755	782	V>D		No	gnomAD
rs755291346	782	V>F		No	ExAC TOPMed gnomAD
rs755291346	782	V>I		No	ExAC TOPMed gnomAD
rs1341994272	783	T>I		No	TOPMed
rs532316698	784	H>Q		No	1000Genomes ExAC TOPMed gnomAD
rs1582804554	784	H>Y		No	Ensembl
rs763408803	785	V>L		No	ExAC TOPMed gnomAD
rs763408803	785	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2128692913	787	L>I		No	Ensembl
COSM739482 COSM1647870	789	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs750511195	789	V>L		No	ExAC gnomAD
rs750511195	789	V>M		No	ExAC gnomAD
rs34582164 RCV000971532 VAR_049712	790	N>S		No	ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs761966360	791	D>N		No	ExAC gnomAD
rs2128692877	791	D>V		No	Ensembl
COSM4160150 COSM4160151 rs140511382 RCV000896640	792	M>I	thyroid [Cosmic]	No	cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1426636306	792	M>V		No	gnomAD
rs769023640	793	V>M		No	ExAC TOPMed
rs2128692839	794	V>M		No	Ensembl
rs2128692821	796	S>L		No	Ensembl
rs111621779	797	V>A		No	ESP ExAC TOPMed gnomAD
rs111621779	797	V>D		No	ESP ExAC TOPMed gnomAD
rs2128692803	797	V>F		No	Ensembl
rs2128692803	797	V>I		No	Ensembl
rs2128692785	798	G>C		No	Ensembl
rs2128692775	799	G>E		No	Ensembl
rs1772314649	799	G>R		No	TOPMed
rs1040006908	801	L>F		No	Ensembl
rs1040006908	801	L>I		No	Ensembl
rs759565527	802	Y>*		No	ExAC TOPMed
rs1193257514	803	W>*		No	TOPMed gnomAD
rs200615700	804	T>I		No	1000Genomes ESP ExAC TOPMed gnomAD
RCV000882242 rs200615700	804	T>N		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1159939787	805	T>A		No	TOPMed
rs1772312157	806	L>F		No	TOPMed
rs1772312157	806	L>I		No	TOPMed
rs145036129	807	Y>C		No	ESP ExAC gnomAD
rs1772311416 COSM3619879 COSM3619880	808	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs1307375070	809	V>L		No	TOPMed gnomAD
rs1772310913	810	E>K		No	Ensembl
rs748595080	811	S>G		No	Ensembl
rs780771072	812	T>A		No	ExAC TOPMed gnomAD
rs1772310191	813	R>G		No	Ensembl
rs779132348	813	R>I		No	Ensembl
rs1772309691	813	R>S		No	Ensembl
COSM1672709 rs1216622336 COSM1672708	814	L>I	haematopoietic_and_lymphoid_tissue [Cosmic]	No	cosmic curated gnomAD
rs1216622336	814	L>V		No	gnomAD
rs914246389	815	N>S		No	Ensembl
rs1465256284	816	G>R		No	TOPMed
rs751888809	817	E>*		No	ExAC gnomAD
COSM4537689 COSM4537690	817	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs751888809	817	E>Q		No	ExAC gnomAD
rs780347313	818	S>C		No	ExAC gnomAD
rs780347313	818	S>G		No	ExAC gnomAD
rs2128692570	818	S>N		No	Ensembl
rs2128692570	818	S>T		No	Ensembl
rs2128692553	819	S>F		No	Ensembl
rs1371334533	819	S>T		No	gnomAD
rs2128692537	820	L>F		No	Ensembl
rs1772306735	820	L>P		No	TOPMed
rs544407860	821	V>I		No	TOPMed gnomAD
rs544407860	821	V>L		No	TOPMed gnomAD
rs924426086	822	L>P		No	TOPMed gnomAD
rs924426086	822	L>R		No	TOPMed gnomAD
rs1353818269	823	Q>*		No	gnomAD
rs2128692499	823	Q>H		No	Ensembl
rs765778935	824	T>A		No	ExAC gnomAD
rs761936637	825	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs761936637	825	Q>K		No	ExAC TOPMed gnomAD
rs1772304690	825	Q>P		No	TOPMed gnomAD
rs2128692461	826	P>A		No	Ensembl
rs1682914708	827	W>*		No	Ensembl
rs2128692446	830	G>V		No	Ensembl
rs1454855400	831	K>E		No	gnomAD
rs1269764595	831	K>N		No	TOPMed gnomAD
rs1374573342	832	K>E		No	TOPMed gnomAD
rs981224591	832	K>N		No	TOPMed gnomAD
rs36029166	832	K>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs769788471	834	I>V		No	ExAC TOPMed gnomAD
rs1771908926	836	L>P		No	Ensembl
rs1771908926	836	L>R		No	Ensembl
rs1274193277	837	T>A		No	TOPMed
rs370903490	837	T>N		No	ESP ExAC TOPMed gnomAD
rs1418777494	838	L>S		No	gnomAD
rs1157208285	838	L>V		No	TOPMed gnomAD
rs199731317	839	D>E		No	ESP ExAC TOPMed gnomAD
rs780718091	839	D>H		No	ExAC gnomAD
rs780718091	839	D>N		No	ExAC gnomAD
rs1484966865	840	L>F		No	gnomAD
rs1771904828	840	L>H		No	TOPMed
rs1771904828	840	L>P		No	TOPMed
rs746721106	841	S>R		No	ExAC gnomAD
rs1771904350	842	D>G		No	TOPMed
rs2128685170	842	D>Y		No	Ensembl
rs2128685156	843	G>R		No	Ensembl
rs1211997454	844	L>F		No	TOPMed gnomAD
rs1211997454	844	L>I		No	TOPMed gnomAD
rs201920657	846	Y>C		No	ExAC TOPMed gnomAD
rs201920657	846	Y>S		No	ExAC TOPMed gnomAD
rs779266768	847	W>*		No	ExAC TOPMed gnomAD
rs779266768	847	W>C		No	ExAC TOPMed gnomAD
rs1771902550	847	W>L		No	TOPMed
rs61729670	847	W>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs757880878	848	L>W		No	ExAC gnomAD
rs1353443254	849	V>I		No	gnomAD
rs764329833	850	Q>*		No	ExAC gnomAD
COSM739486 COSM1647872	850	Q>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	853	Q>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	853	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4992419 COSM4992418	854	C>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1460047377	855	I>F		No	Ensembl
TCGA novel	855	I>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1771900046	856	H>Q		No	Ensembl
COSM3619878 COSM3619877	856	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs752798332	857	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA
rs1771899359	857	L>R		No	TOPMed
rs767816340	858	Y>*		No	ExAC gnomAD
rs762602217	859	T>K		No	ExAC TOPMed gnomAD
rs1231286589	860	A>D		No	TOPMed gnomAD
rs1771897924	861	V>A		No	TOPMed
rs2128684955 COSM3619874 COSM3619873	862	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1161406135	862	L>P		No	gnomAD
rs146533107	863	R>G		No	ESP ExAC TOPMed gnomAD
rs142979736	863	R>L		No	ESP ExAC TOPMed gnomAD
rs142979736	863	R>Q		No	ESP ExAC TOPMed gnomAD
COSM1072591 COSM3619872 rs146533107 COSM1072593	863	R>W	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
COSM3619870 rs768095857 COSM3619871	865	Q>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
VAR_041450	865	Q>H	a lung large cell carcinoma sample; somatic mutation [UniProt]	No	UniProt
COSM1440079 COSM1440080 rs776103430	865	Q>R	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs979014772	866	S>N		No	TOPMed gnomAD
rs934233893	866	S>R		No	TOPMed
rs1358315577	867	T>A		No	gnomAD
rs767616403	869	D>N		No	ExAC TOPMed gnomAD
rs755272149	869	D>V		No	ExAC gnomAD
rs922898650	870	T>A		No	TOPMed
rs973411916	870	T>I		No	TOPMed gnomAD
rs973411916	870	T>N		No	TOPMed gnomAD
rs750183711	871	T>A		No	ExAC gnomAD
rs1370586180	873	T>I		No	gnomAD
rs1780227164	874	E>A		No	TOPMed
rs765076581	875	F>S		No	ExAC
rs963388678	875	F>V		No	Ensembl
rs539820527	876	A>T		No	1000Genomes ExAC gnomAD
rs2128662668	876	A>V		No	Ensembl
TCGA novel	877	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1780225719	877	A>S		No	Ensembl
rs2128662654	877	A>V		No	Ensembl
rs1394879221	878	W>*		No	gnomAD
rs2128662640	878	W>L		No	Ensembl
rs776486332	878	W>R		No	ExAC gnomAD
rs760081041	879	S>N		No	ExAC gnomAD
rs760081041	879	S>T		No	ExAC gnomAD
rs775105679	880	T>A		No	ExAC gnomAD
rs2128662598	880	T>I		No	Ensembl
rs1172204797	881	S>*		No	gnomAD
rs1562321708	883	I>T		No	Ensembl
rs146570171 COSM109622	884	S>F	skin [Cosmic]	No	cosmic curated Ensembl
rs1780221892	885	Q>R		No	TOPMed
rs117865341	887	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs369516763	888	L>Q		No	ESP ExAC TOPMed gnomAD
rs369516763	888	L>R		No	ESP ExAC TOPMed gnomAD
rs1476549252	889	M>I		No	TOPMed gnomAD
rs763350500	889	M>K		No	Ensembl
rs1452840689	889	M>L		No	TOPMed gnomAD
rs763350500	889	M>R		No	Ensembl
rs1248261976	890	Y>C		No	gnomAD
rs1780219326	890	Y>D		No	Ensembl
COSM95208 rs749698242	891	Y>C	lung [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs749698242	891	Y>F		No	ExAC TOPMed gnomAD
rs557592852	891	Y>H		No	1000Genomes ExAC TOPMed gnomAD
rs1240882470	892	S>G		No	gnomAD
rs1240882470	892	S>R		No	gnomAD
rs778372043	893	G>C		No	ExAC gnomAD
rs2128662421	893	G>D		No	Ensembl
rs2128662421	893	G>V		No	Ensembl
rs748148750	894	R>G		No	ExAC TOPMed gnomAD
rs535778217	894	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs535778217	894	R>Q		No	1000Genomes ExAC TOPMed gnomAD
rs748148750	894	R>W		No	ExAC TOPMed gnomAD
rs1780216629	896	F>L		No	TOPMed
rs866590541	897	W>*		No	gnomAD
rs866590541	897	W>C		No	gnomAD
rs1410939393	897	W>R		No	gnomAD
rs1780215163	898	I>V		No	Ensembl
rs1255849184	899	N>D		No	gnomAD
rs2128662310	900	G>D		No	Ensembl
rs2128662310	900	G>V		No	Ensembl
rs1374376426	901	F>L		No	TOPMed gnomAD
rs1780213284	902	R>M		No	Ensembl
rs780260360	903	I>M		No	ExAC TOPMed gnomAD
rs751748673	903	I>V		No	ExAC gnomAD
rs1780211548	904	I>M		No	Ensembl
rs1030521764	904	I>S		No	TOPMed gnomAD
rs1030521764	904	I>T		No	TOPMed gnomAD
rs984585547	905	T>I		No	TOPMed
rs984585547	905	T>R		No	TOPMed
rs757007505	906	T>I		No	ExAC gnomAD
rs1361557179	908	E>Q		No	gnomAD
rs1780209755	909	I>L		No	TOPMed
rs763987499	909	I>T		No	ExAC TOPMed gnomAD
rs1316079381	910	G>C		No	TOPMed gnomAD
rs371677605	910	G>D		No	ESP ExAC TOPMed gnomAD
rs371677605	910	G>V		No	ESP ExAC TOPMed gnomAD
rs1314684858	911	Q>E		No	TOPMed
rs2128662162	913	T>S		No	Ensembl
rs1357348863	915	V>A		No	TOPMed
rs2128662138	917	V>I		No	Ensembl
COSM4864798 COSM1072590	919	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774104513	920	P>A		No	ExAC gnomAD
rs2128662104	920	P>L		No	Ensembl
rs774104513	920	P>S		No	ExAC gnomAD
rs2128662081	921	A>P		No	Ensembl
rs2128662081	921	A>S		No	Ensembl
rs2128662081	921	A>T		No	Ensembl
rs2128662073	921	A>V		No	Ensembl
rs368975857	922	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP NCI-TCGA TOPMed gnomAD
rs368975857	922	R>K		No	ESP TOPMed gnomAD
rs1780204616	925	Q>H		No	TOPMed
rs1780205071	925	Q>K		No	TOPMed
rs770726875	925	Q>P		No	ExAC TOPMed gnomAD
rs770726875	925	Q>R		No	ExAC TOPMed gnomAD
rs1203951044	927	T>K		No	TOPMed gnomAD
rs1339675608	929	I>V		No	TOPMed gnomAD
rs2128662003	930	Q>R		No	Ensembl
rs145830106	931	T>A		No	ESP ExAC TOPMed gnomAD
rs145830106	931	T>S		No	ESP ExAC TOPMed gnomAD
rs748750515	932	S>A		No	1000Genomes ExAC gnomAD
COSM3828893 COSM3828894	932	S>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs781566302	935	P>H		No	ExAC gnomAD
rs768716438	937	P>T		No	ExAC TOPMed gnomAD
COSM3157824 COSM3157823	938	G>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128661919	938	G>R		No	Ensembl
rs2128661290	938	G>V		No	Ensembl
rs750031784	939	N>D		No	ExAC gnomAD
rs2128661250	939	N>K		No	Ensembl
rs764831115	939	N>S		No	ExAC gnomAD
rs750031784	939	N>Y		No	ExAC gnomAD
rs2128661247	940	F>L		No	Ensembl
rs2128661245	940	F>S		No	Ensembl
COSM228087	941	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs558256028	941	S>P		No	1000Genomes ExAC gnomAD
rs1780160191	942	F>L		No	TOPMed
rs115534545 RCV000912448	942	F>L		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs764657413	943	T>A		No	ExAC gnomAD
rs2128661194	943	T>I		No	Ensembl
rs2128661194	943	T>S		No	Ensembl
rs764657413	943	T>S		No	ExAC gnomAD
rs2128661158	944	P>R		No	Ensembl
rs2128661174	944	P>S		No	Ensembl
rs999670889	945	K>*		No	TOPMed
rs999670889	945	K>E		No	TOPMed
rs140885860	945	K>N		No	ESP TOPMed
TCGA novel	945	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs147172890	946	V>F		No	ESP ExAC TOPMed gnomAD
rs2128661118	946	V>G		No	Ensembl
rs147172890	946	V>I		No	ESP ExAC TOPMed gnomAD
rs147172890	946	V>L		No	ESP ExAC TOPMed gnomAD
rs2128661115	947	I>F		No	Ensembl
rs2128661108	947	I>T		No	Ensembl
rs1169032817	948	P>A		No	gnomAD
rs774580552	948	P>L		No	ExAC TOPMed gnomAD
rs774580552	948	P>Q		No	ExAC TOPMed gnomAD
rs774580552	948	P>R		No	ExAC TOPMed gnomAD
rs1169032817	948	P>S		No	gnomAD
rs2128661083	949	D>H		No	Ensembl
rs2128661075	949	D>V		No	Ensembl
rs2128661083 TCGA novel	949	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1251397232	950	S>A		No	gnomAD
rs2128661063	950	S>C		No	Ensembl
rs2128661063	950	S>F		No	Ensembl
rs2128661040	951	V>D		No	Ensembl
rs1780157829	951	V>F		No	Ensembl
rs1780157829	951	V>I		No	Ensembl
rs1780157829	951	V>L		No	Ensembl
rs2128661021	952	Q>*		No	Ensembl
rs2128661021	952	Q>E		No	Ensembl
rs2128660999	953	E>D		No	Ensembl
rs2128661012	953	E>Q		No	Ensembl
rs2128661003	953	E>V		No	Ensembl
rs2128660984	954	S>C		No	Ensembl
rs2128660984	954	S>F		No	Ensembl
rs2128660995	954	S>T		No	Ensembl
rs2128660984	954	S>Y		No	Ensembl
rs2128660967	955	S>*		No	Ensembl
rs2128660967	955	S>L		No	Ensembl
rs2128660973	955	S>P		No	Ensembl
rs2128660950	957	R>G		No	Ensembl
rs771104079	957	R>K		No	ExAC gnomAD
rs771104079	957	R>M		No	ExAC gnomAD
rs191810593	957	R>S		No	1000Genomes ExAC TOPMed gnomAD
rs2128660950	957	R>W		No	Ensembl
rs754956947	958	I>F		No	ExAC gnomAD
rs754956947	958	I>V		No	ExAC gnomAD
rs2229078	959	E>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1780156917	959	E>K		No	gnomAD
rs1780156917	959	E>Q		No	gnomAD
rs866331955	960	G>*		No	Ensembl
rs868806134	960	G>A		No	Ensembl
rs868806134	960	G>E		No	Ensembl
rs866331955	960	G>R		No	Ensembl
TCGA novel	961	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128660848	961	N>K		No	Ensembl
rs1562320406	961	N>S		No	Ensembl
rs2128660866	961	N>Y		No	Ensembl
TCGA novel	962	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel rs2128660832	962	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs780146524	962	A>P		No	ExAC gnomAD
rs780146524	962	A>S		No	ExAC gnomAD
rs780146524	962	A>T		No	ExAC gnomAD
rs2128660832	962	A>V		No	Ensembl
rs1780155274	963	S>*		No	Ensembl
rs1780155274	963	S>L		No	Ensembl
rs1275770178	964	S>C		No	gnomAD
rs1275770178	964	S>G		No	gnomAD
rs2128660789	964	S>I		No	Ensembl
rs2128660789	964	S>N		No	Ensembl
rs2128660782	964	S>R		No	Ensembl
rs2128660789	964	S>T		No	Ensembl
rs2128660766	965	F>L		No	Ensembl
rs1231099518	965	F>L		No	gnomAD
rs2128660752	966	Q>*		No	Ensembl
rs2128660752	966	Q>E		No	Ensembl
rs371626074	966	Q>R		No	ESP ExAC TOPMed gnomAD
rs764921433	967	I>M		No	ExAC gnomAD
rs2128660726	967	I>N		No	Ensembl
rs2128660701	968	L>P		No	Ensembl
rs2128660707	968	L>V		No	Ensembl
rs2128660664	969	W>*		No	Ensembl
COSM1264497 COSM1264498 rs2128660655	969	W>C	oesophagus [Cosmic]	No	cosmic curated Ensembl
rs2128660674	969	W>R		No	Ensembl
rs2128660664	969	W>S		No	Ensembl
rs756900916	970	N>K		No	ExAC gnomAD
rs2128660648	970	N>T		No	Ensembl
rs2128660629	971	G>A		No	Ensembl
rs199835491	971	G>C		No	ExAC gnomAD
rs2128660629	971	G>D		No	Ensembl
rs1369931780	972	P>A		No	gnomAD
rs761029946	972	P>H		No	ExAC gnomAD
rs761029946	972	P>L		No	ExAC gnomAD
rs761029946	972	P>R		No	ExAC gnomAD
rs1369931780	972	P>S		No	gnomAD
rs1369931780	972	P>T		No	gnomAD
rs2128660579	973	P>A		No	Ensembl
rs917101052	973	P>L		No	TOPMed gnomAD
rs917101052	973	P>R		No	TOPMed gnomAD
rs2128660579	973	P>S		No	Ensembl
rs2128660579	973	P>T		No	Ensembl
rs759586931	974	A>G		No	ExAC TOPMed gnomAD
rs376831258	974	A>P		No	ExAC TOPMed gnomAD
rs376831258	974	A>S		No	ExAC TOPMed gnomAD
rs376831258	974	A>T		No	ExAC TOPMed gnomAD
rs759586931	974	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2128660533	975	V>E		No	Ensembl
rs2128660545	975	V>I		No	Ensembl
rs2128660545	975	V>L		No	Ensembl
rs749533554	976	D>A		No	ExAC TOPMed gnomAD
rs2128660497	976	D>E		No	Ensembl
rs749533554	976	D>G		No	ExAC TOPMed gnomAD
rs771176235	976	D>H		No	ExAC TOPMed gnomAD
rs771176235	976	D>N		No	ExAC TOPMed gnomAD
rs749533554	976	D>V		No	ExAC TOPMed gnomAD
rs771176235	976	D>Y		No	ExAC TOPMed gnomAD
rs2128660476	977	W>*		No	Ensembl
TCGA novel rs2128660472	977	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128660472	977	W>C		No	Ensembl
rs2128660488	977	W>G		No	Ensembl
rs2128660476	977	W>L		No	Ensembl
rs2128660488	977	W>R		No	Ensembl
rs370129182	978	G>A		No	ESP ExAC gnomAD
rs978782444	978	G>C		No	TOPMed gnomAD
rs370129182	978	G>D		No	ESP ExAC gnomAD
rs978782444	978	G>R		No	TOPMed gnomAD
rs978782444	978	G>S		No	TOPMed gnomAD
rs370129182	978	G>V		No	ESP ExAC gnomAD
rs139467403	979	V>A		No	ESP ExAC TOPMed gnomAD
rs139467403	979	V>E		No	ESP ExAC TOPMed gnomAD
rs1780150593	979	V>I		No	Ensembl
rs1780150593	979	V>L		No	Ensembl
rs2128660414	980	V>I		No	Ensembl
rs2128660414	980	V>L		No	Ensembl
rs746834710	981	F>L		No	ExAC gnomAD
rs2128660373	982	Y>*		No	Ensembl
rs1255828711	982	Y>*		No	gnomAD
COSM6104786 COSM594205 COSM594206 rs2128660381 COSM1650494 COSM6104787	982	Y>F	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic Ensembl
rs2128660391	982	Y>N		No	Ensembl
rs2128660381	982	Y>S		No	Ensembl
rs2128660359	983	S>N		No	Ensembl
rs374498314	983	S>R		No	ESP ExAC gnomAD
rs2128660359	983	S>T		No	Ensembl
rs2128660340	984	V>E		No	Ensembl
rs1780149722	985	E>K		No	Ensembl
rs1780149722	985	E>Q		No	Ensembl
rs2128660312	986	F>Y		No	Ensembl
rs2128660277	987	S>N		No	Ensembl
rs2128660277	987	S>T		No	Ensembl
rs147350512	988	A>G		No	ESP ExAC TOPMed gnomAD
rs1562320184	988	A>P		No	Ensembl
rs147350512	988	A>V		No	ESP ExAC TOPMed gnomAD
rs747041649	989	H>R		No	TOPMed gnomAD
COSM3920642 COSM3920643	989	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756804061	990	S>C		No	ExAC gnomAD
rs756804061	990	S>Y		No	ExAC gnomAD
rs1780147707	991	K>E		No	Ensembl
rs753364114	991	K>N		No	ExAC gnomAD
COSM1329343 rs1287346255 COSM1329344	992	F>L	ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated gnomAD NCI-TCGA Cosmic
rs1456965447	994	A>G		No	gnomAD
rs1456965447 COSM387705 COSM387706	994	A>V	lung [Cosmic]	No	cosmic curated gnomAD
rs1780117442	995	S>R		No	Ensembl
COSM1722623 COSM1722622	996	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1444061608	997	Q>*		No	TOPMed gnomAD
rs1444061608	997	Q>E		No	TOPMed gnomAD
rs772131519	997	Q>R		No	ExAC gnomAD
rs943452007	998	H>R		No	Ensembl
rs2128659447	998	H>Y		No	Ensembl
rs1780115455	999	S>C		No	Ensembl
rs778913413	999	S>P		No	ExAC TOPMed gnomAD
rs778913413	999	S>T		No	ExAC TOPMed gnomAD
rs1368425429	1000	L>F		No	TOPMed gnomAD
rs2128659369	1001	P>L		No	Ensembl
rs1028345885	1001	P>T		No	TOPMed
rs770304963	1002	V>A		No	ExAC TOPMed gnomAD
rs2128659365	1002	V>I		No	Ensembl
rs1257766314	1004	T>I		No	TOPMed gnomAD
rs2128659352	1006	E>*		No	Ensembl
rs748850729	1007	G>E		No	ExAC TOPMed
rs141385549	1007	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP NCI-TCGA TOPMed gnomAD
rs748850729	1007	G>V		No	ExAC TOPMed
rs777378778	1009	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs755801647	1009	E>V		No	ExAC gnomAD
rs200278757	1010	P>A		No	ESP ExAC TOPMed gnomAD
rs200278757	1010	P>S		No	ESP ExAC TOPMed gnomAD
rs200278757	1010	P>T		No	ESP ExAC TOPMed gnomAD
rs1302519741	1011	Y>*		No	TOPMed gnomAD
rs141171688	1011	Y>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141171688	1011	Y>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs781590553	1011	Y>H		No	ExAC gnomAD
rs1780111403	1012	A>T		No	TOPMed
rs751947980	1012	A>V		No	ExAC TOPMed gnomAD
rs766943523	1013	L>F		No	ExAC gnomAD
rs1323268309	1014	F>L		No	gnomAD
rs2128659258	1015	N>I		No	Ensembl
rs1295211193	1016	L>F		No	TOPMed gnomAD
rs2128659235	1017	S>F		No	Ensembl
rs1434611083	1017	S>P		No	TOPMed gnomAD
TCGA novel	1018	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1366263868	1019	T>I		No	gnomAD
COSM3374025 COSM3374024	1020	P>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs762895148	1021	Y>C		No	ExAC TOPMed gnomAD
rs1285354534	1022	T>I		No	TOPMed
rs1285354534	1022	T>S		No	TOPMed
rs1385190956	1023	Y>*		No	gnomAD
rs2128659151	1024	W>C		No	Ensembl
rs1780108004	1024	W>G		No	TOPMed
rs1780108004	1024	W>R		No	TOPMed
rs750566587 COSM3619865 COSM3619864	1025	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs2128659143	1025	G>V		No	Ensembl
rs765527922	1026	K>*		No	ExAC gnomAD
rs765527922	1026	K>E		No	ExAC gnomAD
RCV000912447 rs143148482	1026	K>M		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000897322 rs149513638	1027	G>D		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1381266956	1029	K>E		No	gnomAD
RCV000736227 rs770947269	1030	T>A		No	ClinVar ExAC dbSNP
TCGA novel	1031	S>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs748712887	1032	L>P		No	ExAC gnomAD
COSM229019 rs772772410 COSM229020 COSM3928055	1035	R>*	Variant assessed as Somatic; HIGH impact. skin [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA
rs769418999	1035	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2128659032	1036	A>T		No	Ensembl
rs1780103139	1036	A>V		No	Ensembl
rs2128659009	1037	P>H		No	Ensembl
rs747744775	1037	P>S		No	ExAC gnomAD
rs1489445418	1038	E>A		No	gnomAD
TCGA novel	1038	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128658993	1038	E>Q		No	Ensembl
rs755260953	1040	V>F		No	ExAC TOPMed gnomAD
rs755260953	1040	V>I		No	ExAC TOPMed gnomAD
rs1185167609	1041	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1185167609	1041	P>T		No	gnomAD
rs747095069	1043	A>P		No	ExAC TOPMed gnomAD
rs747095069 COSM314880 COSM314879	1043	A>S	lung [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs747095069	1043	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs756422681	1047	P>T		No	ExAC gnomAD
rs1779917967	1048	R>S		No	Ensembl
rs1327147007	1049	I>M		No	gnomAD
rs751294687	1051	I>T		No	ExAC gnomAD
rs1779917011 COSM3777050 COSM3777051	1051	I>V	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs2128655485	1052	L>*		No	Ensembl
rs766135828	1052	L>F		No	ExAC TOPMed gnomAD
rs534570805	1053	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs1282740458	1054	S>G		No	gnomAD
rs1327113707	1055	G>A		No	TOPMed gnomAD
rs2128655436	1057	C>F		No	Ensembl
rs200648331	1057	C>R		No	1000Genomes ExAC TOPMed gnomAD
rs1210694550	1058	C>Y		No	Ensembl
rs1339445079	1059	N>K		No	TOPMed gnomAD
rs765184541	1060	K>E		No	ExAC TOPMed gnomAD
rs746698627	1061	N>D		No	gnomAD
rs1582741918	1061	N>S		No	Ensembl
rs761293495	1062	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2128655385	1063	V>D		No	Ensembl
rs1779913382	1064	V>A		No	gnomAD
rs2128655379	1064	V>L		No	Ensembl
rs776246659	1065	V>A		No	ExAC TOPMed gnomAD
rs776246659	1065	V>E		No	ExAC TOPMed gnomAD
rs1779912617	1066	E>*		No	gnomAD
rs1779912617	1066	E>Q		No	gnomAD
TCGA novel	1067	F>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1779912143	1068	R>T		No	TOPMed
rs1779911466	1069	W>*		No	Ensembl
rs1779911032	1070	N>K		No	Ensembl
rs2128655309	1071	K>E		No	Ensembl
rs1258683387	1071	K>N		No	TOPMed gnomAD
rs1475745760	1073	K>M		No	TOPMed
rs1159595080	1074	H>P		No	TOPMed
TCGA novel	1076	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs61729673	1077	G>A		No	ESP ExAC gnomAD
rs61729673	1077	G>E		No	ESP ExAC gnomAD
rs902648185	1077	G>R		No	TOPMed
rs61729673	1077	G>V		No	ESP ExAC gnomAD
rs1463744260	1078	V>E		No	gnomAD
rs1458536244	1078	V>L		No	TOPMed gnomAD
rs1458536244	1078	V>M		No	TOPMed gnomAD
COSM277098	1081	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1779906931	1081	K>R		No	Ensembl
COSM3619860 COSM3619861	1083	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs771605740	1084	I>T		No	ExAC gnomAD
rs193271148	1084	I>V		No	1000Genomes ExAC TOPMed gnomAD
rs1041559440	1085	F>L		No	Ensembl
rs777710055	1086	Y>C		No	TOPMed gnomAD
rs1357481298	1087	N>S		No	gnomAD
rs1779904625	1088	I>L		No	TOPMed
rs777962826	1088	I>M		No	ExAC gnomAD
rs145056487	1088	I>T		No	ESP ExAC TOPMed gnomAD
rs1779904625	1088	I>V		No	TOPMed
COSM1647873 COSM739489 COSM739488 rs1319247583	1089	S>C	lung [Cosmic]	No	cosmic curated gnomAD
rs1319247583	1089	S>F		No	gnomAD
rs772396536	1090	N>D		No	ExAC TOPMed gnomAD
rs1582741417	1090	N>S		No	TOPMed
rs781304519	1091	Q>E		No	ExAC TOPMed gnomAD
rs781304519	1091	Q>K		No	ExAC TOPMed gnomAD
rs1404760277	1091	Q>L		No	TOPMed gnomAD
rs1404760277	1091	Q>P		No	TOPMed gnomAD
rs1404760277 COSM1180436 COSM1180437	1091	Q>R	prostate [Cosmic]	No	cosmic curated TOPMed gnomAD
COSM3619858 COSM3619859 rs2128655040	1092	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128655030	1093	I>T		No	Ensembl
rs758142339	1093	I>V		No	ExAC gnomAD
rs765131630	1095	N>D		No	ExAC TOPMed gnomAD
RCV000959656 rs115286894	1095	N>I		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs765131630	1095	N>Y		No	ExAC TOPMed gnomAD
rs2128654983	1099	E>Q		No	Ensembl
COSM1440078 COSM4784548	1100	D>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1486897923	1100	D>N		No	gnomAD
rs1779900810	1100	D>V		No	Ensembl
COSM1720295 COSM1720294 rs200145587	1101	W>*	NS [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs200145587	1101	W>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1409023701	1101	W>R		No	TOPMed gnomAD
rs867263615	1102	I>S		No	gnomAD
rs867263615	1102	I>T		No	gnomAD
rs760109353	1103	A>G		No	ExAC gnomAD
rs2128654942	1103	A>T		No	Ensembl
rs760109353	1103	A>V		No	ExAC gnomAD
rs2128654932	1104	V>F		No	Ensembl
rs1452738796	1105	N>H		No	TOPMed gnomAD
rs775158731	1105	N>S		No	ExAC TOPMed gnomAD
rs759947584	1106	V>A		No	ExAC TOPMed gnomAD
rs1779899006	1106	V>I		No	gnomAD
rs774918950	1107	T>P		No	ExAC gnomAD
rs992780681	1107	T>S		No	gnomAD
rs2128654871	1108	P>*		No	Ensembl
rs754292558 COSM1697831 COSM1697832	1108	P>L	skin [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
COSM1720293 COSM1720292	1108	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128654853	1108	P>T		No	Ensembl
VAR_030650 rs2229079	1109	S>L		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1191924885	1110	V>L		No	TOPMed gnomAD
rs1191924885	1110	V>M		No	TOPMed gnomAD
rs1779896417	1111	M>T		No	Ensembl
rs1477759913	1111	M>V		No	gnomAD
rs375027302	1113	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs2128654771	1114	Q>*		No	Ensembl
rs1304686859	1115	L>V		No	gnomAD
rs2128654750	1118	M>K		No	Ensembl
rs1427586364	1118	M>L		No	gnomAD
TCGA novel	1118	M>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1427586364	1118	M>V		No	gnomAD
rs2128654739	1119	S>I		No	Ensembl
rs2128654739	1119	S>N		No	Ensembl
TCGA novel	1120	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs748201668	1121	R>G		No	ExAC
COSM1072587 COSM4872449	1121	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128654717	1121	R>S		No	Ensembl
rs150397191	1121	R>T		No	ESP ExAC TOPMed gnomAD
COSM5813293 COSM5813292	1122	C>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs755237907	1122	C>W		No	ExAC gnomAD
rs1562316462	1123	F>I		No	TOPMed
rs1779894539	1123	F>S		No	Ensembl
rs750215153	1126	F>S		No	ExAC TOPMed gnomAD
rs2128654674	1127	Q>R		No	Ensembl
COSM739491 COSM1647874	1129	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs757007708	1130	A>S		No	ExAC gnomAD
TCGA novel	1132	T>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs767073922	1133	S>C		No	ExAC TOPMed gnomAD
rs767073922	1133	S>F		No	ExAC TOPMed gnomAD
rs1779703269	1134	K>E		No	Ensembl
rs142442666	1135	G>A		No	ESP ExAC TOPMed gnomAD
rs142442666	1135	G>E		No	ESP ExAC TOPMed gnomAD
rs151330473	1135	G>R		No	ESP ExAC TOPMed gnomAD
rs1779701479	1136	P>L		No	Ensembl
rs1312405953	1136	P>S		No	Ensembl
rs2128650395	1137	G>A		No	Ensembl
rs2128650409	1137	G>R		No	Ensembl
rs2128650367	1139	Y>F		No	Ensembl
rs140926672	1141	D>E		No	1000Genomes ESP ExAC gnomAD
rs752818337	1141	D>N		No	Ensembl
rs777135627	1142	V>F		No	ExAC TOPMed gnomAD
rs777135627	1142	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
COSM4949238 COSM1440076	1143	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1179127158	1143	V>G		No	TOPMed gnomAD
rs768658324	1143	V>I		No	ExAC gnomAD
rs1452552506	1144	K>R		No	TOPMed gnomAD
rs1007387781	1145	S>T		No	TOPMed
rs2128650279	1146	T>A		No	Ensembl
rs2128650269	1146	T>K		No	Ensembl
rs375496236	1147	T>I		No	ESP ExAC TOPMed gnomAD
rs1429075405	1148	S>P		No	TOPMed gnomAD
rs775665843	1149	E>*		No	ExAC gnomAD
COSM594208 COSM594207 COSM1650495 rs775665843	1149	E>K	lung [Cosmic]	No	cosmic curated ExAC gnomAD
rs779824765	1150	I>V		No	ExAC gnomAD
COSM3857805 COSM3857806	1152	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1311786162	1154	P>L		No	gnomAD
COSM3619855 COSM3619854	1154	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs762243820	1155	H>Y		No	ExAC TOPMed gnomAD
rs1439883984	1157	I>M		No	TOPMed
rs2128649134	1158	T>I		No	Ensembl
rs1434469853	1159	L>F		No	gnomAD
rs2128649092	1161	G>C		No	Ensembl
rs2128649084	1161	G>V		No	Ensembl
rs1779652984	1162	N>S		No	TOPMed gnomAD
rs775612586	1163	K>M		No	ExAC TOPMed gnomAD
TCGA novel	1163	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs760713115	1163	K>Q		No	ExAC TOPMed gnomAD
rs775612586	1163	K>R		No	ExAC TOPMed gnomAD
rs772324949	1164	I>K		No	1000Genomes ExAC gnomAD
rs772324949	1164	I>T		No	1000Genomes ExAC gnomAD
rs1444817510	1164	I>V		No	gnomAD
rs759618879	1165	V>A		No	ExAC TOPMed gnomAD
COSM1440074 COSM3157786 rs748436511	1167	L>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
COSM1440072 COSM5143985 rs748436511	1167	L>F	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs1278003360	1167	L>S		No	TOPMed
rs1779650281	1168	D>E		No	TOPMed
rs2128648997	1168	D>H		No	Ensembl
rs2128648997	1168	D>Y		No	Ensembl
rs769432383	1169	M>T		No	ExAC TOPMed gnomAD
rs1779650070	1169	M>V		No	Ensembl
rs2128648967	1173	Q>E		No	Ensembl
rs2128648957	1173	Q>L		No	Ensembl
rs747975385	1174	V>I		No	ExAC gnomAD
rs1779649150	1175	V>L		No	gnomAD
rs1779649150	1175	V>M		No	gnomAD
COSM1440070 rs370524859 COSM1440069 COSM4782966	1177	T>M	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs2128648907	1178	F>S		No	Ensembl
rs2128648907	1178	F>Y		No	Ensembl
rs2128648897	1179	S>L		No	Ensembl
rs2128648869	1180	A>G		No	Ensembl
rs887790221	1180	A>P		No	TOPMed gnomAD
rs887790221 COSM1072581 COSM3920641 COSM1072579	1180	A>T	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs2128648869	1180	A>V		No	Ensembl
rs1038505092	1181	E>G		No	Ensembl
rs1440893130	1181	E>K		No	Ensembl
TCGA novel	1181	E>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1228020371	1182	R>S		No	gnomAD
rs2128648828	1183	V>I		No	Ensembl
rs1390676503	1185	S>G		No	TOPMed gnomAD
rs1304093001	1185	S>N		No	TOPMed gnomAD
rs1390676503	1185	S>R		No	TOPMed gnomAD
rs377528980	1186	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1366995131	1186	A>V		No	gnomAD
rs749977900	1187	V>F		No	ExAC TOPMed gnomAD
rs749977900	1187	V>I		No	ExAC TOPMed gnomAD
rs1779644374	1189	Y>C		No	TOPMed
rs778659970	1189	Y>N		No	ExAC gnomAD
rs986632095	1190	T>I		No	Ensembl
rs1395082157	1190	T>P		No	TOPMed gnomAD
rs754239222	1191	A>P		No	ExAC TOPMed gnomAD
rs754239222	1191	A>T		No	ExAC TOPMed gnomAD
rs1440151759	1192	D>G		No	TOPMed
rs2128648711	1192	D>N		No	Ensembl
COSM3857804 COSM3857803	1192	D>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128648711	1192	D>Y		No	Ensembl
rs764578818	1193	N>D		No	ExAC TOPMed gnomAD
rs2128648676	1193	N>I		No	Ensembl
rs144455439	1193	N>K		No	ESP ExAC TOPMed gnomAD
rs764578818	1193	N>Y		No	ExAC TOPMed gnomAD
rs753216129	1194	E>K		No	ExAC gnomAD
rs767426303	1195	M>I		No	ExAC gnomAD
rs567175783	1195	M>T		No	gnomAD
rs142826369	1196	G>*		No	ExAC TOPMed gnomAD
TCGA novel rs1779640971	1196	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
COSM109716 rs142826369	1196	G>R	skin [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs2128648616	1199	A>V		No	Ensembl
rs1213277193	1201	G>R		No	TOPMed gnomAD
rs2128648592	1201	G>V		No	Ensembl
rs1213277193	1201	G>W		No	TOPMed gnomAD
rs774383914	1202	D>G		No	ExAC gnomAD
rs1231203749	1202	D>Y		No	TOPMed gnomAD
rs1054726851	1203	S>L		No	TOPMed gnomAD
rs1779639321	1203	S>T		No	Ensembl
rs1407363767	1204	L>F		No	gnomAD
rs761671299	1206	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1779637694	1206	L>P		No	TOPMed
rs2128648484	1208	H>L		No	Ensembl
rs35302901	1209	L>*		No	ESP ExAC TOPMed gnomAD
rs201618389	1210	H>P		No	1000Genomes ExAC gnomAD
rs2128648459	1210	H>Y		No	Ensembl
rs746889818	1211	N>S		No	ExAC
COSM284675	1211	N>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs780046038	1212	R>C		No	ExAC TOPMed gnomAD
COSM1072578 rs771443531 COSM4874720 COSM1072576	1212	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs771443531	1212	R>P		No	ExAC TOPMed gnomAD
rs780046038	1212	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1249324272	1213	S>C		No	TOPMed gnomAD
rs1779634540	1214	S>C		No	TOPMed
rs1181216517	1214	S>N		No	gnomAD
rs1181216517	1214	S>T		No	gnomAD
rs1779634100	1215	S>T		No	TOPMed gnomAD
rs2128648369	1216	E>K		No	Ensembl
TCGA novel	1218	F>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs907999496	1219	Q>R		No	Ensembl
rs1779474622	1220	D>V		No	gnomAD
TCGA novel	1221	S>H	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs777430404	1221	S>L		No	ExAC gnomAD
rs1282834794	1221	S>T		No	gnomAD
rs781517393	1223	V>D		No	ExAC gnomAD
rs748591196	1223	V>F		No	ExAC TOPMed gnomAD
rs1459800881	1225	D>N		No	gnomAD
rs755577962	1229	I>T		No	ExAC TOPMed gnomAD
rs2128645864	1230	T>I		No	Ensembl
rs766512849	1231	I>S		No	ExAC TOPMed gnomAD
rs766512849	1231	I>T		No	ExAC TOPMed gnomAD
rs1779470889	1231	I>V		No	TOPMed
rs1161261865	1232	D>G		No	TOPMed gnomAD
rs550870633	1232	D>N		No	1000Genomes ExAC TOPMed gnomAD
rs550870633	1232	D>Y		No	1000Genomes ExAC TOPMed gnomAD
rs1239630506	1233	W>*		No	gnomAD
rs1779468824	1233	W>C		No	TOPMed
rs1444191883	1234	I>T		No	gnomAD
rs1488238763	1234	I>V		No	TOPMed gnomAD
rs558769547	1236	R>M		No	Ensembl
rs376300326	1238	L>I		No	ESP TOPMed gnomAD
rs765579396	1238	L>P		No	ExAC TOPMed gnomAD
rs765579396	1238	L>R		No	ExAC TOPMed gnomAD
rs56192249	1239	Y>C		No	1000Genomes ExAC TOPMed gnomAD
VAR_041451 rs56192249	1239	Y>F		No	UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1027270934	1241	A>E		No	TOPMed gnomAD
rs1027270934	1241	A>V		No	TOPMed gnomAD
rs767342486	1243	K>R		No	ExAC gnomAD
COSM4866627 COSM1072575	1244	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1779465754	1244	E>K		No	TOPMed
rs994551577	1245	S>L		No	TOPMed
rs905591135	1246	Q>H		No	TOPMed gnomAD
TCGA novel	1247	N>M	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1456027028	1248	G>R		No	TOPMed gnomAD
rs770388201	1249	M>I		No	ExAC TOPMed gnomAD
rs774159081	1249	M>K		No	ExAC TOPMed gnomAD
rs774159081	1249	M>T		No	ExAC TOPMed gnomAD
rs2128645742	1251	V>I		No	Ensembl
TCGA novel	1252	F>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs772825686	1252	F>I		No	ExAC gnomAD
rs772825686	1252	F>V		No	ExAC gnomAD
rs1779461956	1253	D>G		No	TOPMed
rs923546663	1254	V>A		No	TOPMed gnomAD
rs373788450	1257	E>Q		No	ESP TOPMed
rs769474033	1258	H>L		No	ExAC gnomAD
rs1215089429	1260	V>M		No	TOPMed gnomAD
rs976398256	1261	K>R		No	Ensembl
rs2128645685 COSM2153171 COSM2153170	1263	P>H	Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
COSM5960067 COSM5960066	1264	R>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs866824848	1265	E>D		No	TOPMed
rs1779459474	1265	E>K		No	TOPMed gnomAD
rs1779459474	1265	E>Q		No	TOPMed gnomAD
rs1223560262	1266	V>M		No	TOPMed gnomAD
rs1562310695	1267	K>N		No	Ensembl
rs1779457836	1268	I>F		No	Ensembl
rs369902845	1268	I>N		No	ESP gnomAD
rs369902845	1268	I>S		No	ESP gnomAD
COSM3619853 COSM3619852	1268	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs781664984	1272	N>S		No	ExAC gnomAD
COSM3619851 COSM3619850	1273	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1490594972	1274	T>A		No	TOPMed gnomAD
rs895672289	1274	T>R		No	TOPMed
rs768919164	1275	I>V		No	ExAC TOPMed gnomAD
rs1418866423	1276	I>F		No	gnomAD
rs1324096328	1276	I>T		No	TOPMed gnomAD
rs1779454795	1277	S>C		No	Ensembl
COSM225584 rs1779454795 COSM225583	1277	S>F	NS [Cosmic]	No	cosmic curated Ensembl
rs751309238	1278	F>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs780738813	1281	Y>*		No	ExAC TOPMed gnomAD
rs747487272	1281	Y>D		No	ExAC gnomAD
rs138034064	1282	P>H		No	ESP ExAC TOPMed gnomAD
rs138034064	1282	P>L		No	ESP ExAC TOPMed gnomAD
COSM3619848 COSM3619849 rs1052987141	1282	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs750581358	1283	L>F		No	ExAC TOPMed gnomAD
rs750581358	1283	L>I		No	ExAC TOPMed gnomAD
rs779247154	1284	L>S		No	ExAC gnomAD
rs199725375	1286	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs373090808 COSM3157781 COSM3157780	1286	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs373090808	1286	R>L		No	ESP ExAC TOPMed gnomAD
rs373090808	1286	R>P		No	ESP ExAC TOPMed gnomAD
rs199725375	1286	R>S		No	1000Genomes ExAC TOPMed gnomAD
rs2128644490	1287	L>M		No	Ensembl
rs2128644490	1287	L>V		No	Ensembl
rs1481438598	1288	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs369009006	1289	W>*		No	ESP TOPMed gnomAD
rs754776601	1291	E>D		No	ExAC gnomAD
rs777881304	1291	E>G		No	ExAC gnomAD
rs754051395	1291	E>K		No	ExAC TOPMed gnomAD
rs754051395	1291	E>Q		No	ExAC TOPMed gnomAD
COSM3619847 COSM3619846	1293	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1221206742	1294	N>D		No	Ensembl
COSM1072570 COSM1072572 rs1779361336 COSM4864649	1294	N>S	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic gnomAD
rs918200907	1295	F>I		No	TOPMed gnomAD
rs563695654	1295	F>L		No	1000Genomes ExAC gnomAD
rs575502427	1295	F>Y		No	1000Genomes ExAC gnomAD
rs1562309446	1296	G>C		No	Ensembl
rs762938706	1296	G>D		No	ExAC TOPMed gnomAD
rs762938706	1296	G>V		No	ExAC TOPMed gnomAD
rs1779359915	1297	Y>C		No	TOPMed
rs764738348	1299	M>I		No	ExAC TOPMed gnomAD
rs750376505	1299	M>R		No	ExAC TOPMed gnomAD
rs750376505	1299	M>T		No	ExAC TOPMed gnomAD
rs1453485026	1301	Y>C		No	gnomAD
rs1408460393	1302	Y>C		No	gnomAD
rs1346133891	1305	I>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1346133891	1305	I>T		No	TOPMed gnomAD
rs2128644314	1306	S>N		No	Ensembl
rs1779357345	1307	H>R		No	Ensembl
rs768246519	1309	L>V		No	ExAC gnomAD
rs772575534	1310	H>L		No	ExAC gnomAD
rs772575534	1310	H>R		No	ExAC gnomAD
rs761092788	1310	H>Y		No	ExAC gnomAD
rs1008170196	1311	R>*		No	TOPMed gnomAD
rs62430836	1311	R>L		No	ExAC TOPMed gnomAD
rs62430836	1311	R>P		No	ExAC TOPMed gnomAD
rs62430836 COSM1072567 COSM1072569	1311	R>Q	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs2128644235	1314	Q>*		No	Ensembl
rs2128644230	1314	Q>L		No	Ensembl
rs2128644222	1315	P>S		No	Ensembl
rs1779355056	1316	T>A		No	Ensembl
rs2128644195	1317	A>S		No	Ensembl
rs2128644192	1317	A>V		No	Ensembl
rs1779354843	1318	T>I		No	gnomAD
rs2128644175	1319	N>K		No	Ensembl
rs2128644168	1320	Q>*		No	Ensembl
rs1779354403	1320	Q>R		No	TOPMed gnomAD
rs1203284336	1321	Q>*		No	TOPMed gnomAD
rs1203284336	1321	Q>E		No	TOPMed gnomAD
rs968500864	1321	Q>R		No	TOPMed gnomAD
rs1779353314	1322	N>K		No	Ensembl
rs1779353119	1323	K>I		No	Ensembl
rs1779352896	1324	R>G		No	TOPMed
COSM1072566 COSM4868613	1324	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1779352678 COSM1072563 COSM4874673 COSM1072561	1324	R>S	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated TOPMed NCI-TCGA Cosmic
rs770990202	1326	Q>*		No	ExAC gnomAD
rs749376024	1326	Q>R		No	ExAC gnomAD
rs2128644098	1327	C>F		No	Ensembl
rs756357483	1327	C>R		No	ExAC TOPMed gnomAD
rs2128644098	1327	C>Y		No	Ensembl
rs2128644095	1328	S>F		No	Ensembl
rs1385042218	1329	C>F		No	gnomAD
rs2128644078	1330	N>K		No	Ensembl
rs2128644075	1332	T>S		No	Ensembl
COSM3619845 COSM3619844	1333	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1438970357	1334	F>I		No	Ensembl
rs2128644057	1335	E>*		No	Ensembl
rs779769013	1335	E>D		No	ExAC gnomAD
rs1779350765	1335	E>G		No	TOPMed
rs145742603	1336	L>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1192485576	1337	S>R		No	TOPMed gnomAD
rs1402555599	1340	M>I		No	TOPMed gnomAD
rs553278368	1340	M>K		No	1000Genomes ExAC TOPMed gnomAD
rs553278368	1340	M>T		No	1000Genomes ExAC TOPMed gnomAD
rs1456727448	1341	A>D		No	gnomAD
rs765109582	1341	A>T		No	ExAC gnomAD
rs1456727448	1341	A>V		No	gnomAD
rs1365408486	1343	D>G		No	gnomAD
rs2128643992	1343	D>H		No	Ensembl
rs2128643992 COSM4900320 COSM4900319	1343	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1779346071	1344	T>A		No	Ensembl
rs368099011	1344	T>N		No	TOPMed gnomAD
rs2128643959	1347	L>I		No	Ensembl
rs1162533892	1347	L>R		No	gnomAD
COSM1440067 COSM1440068 rs1779344251	1348	E>D	large_intestine [Cosmic]	No	cosmic curated TOPMed
COSM483327 COSM483328 COSM1645902 rs2128643931	1350	P>Q	kidney Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs2128643936	1350	P>S		No	Ensembl
rs2128643908	1351	L>F		No	Ensembl
rs934940589	1351	L>V		No	gnomAD
rs923571332	1352	I>V		No	Ensembl
rs35269727 VAR_041452	1353	Y>S		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	1354	F>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2128643880	1355	A>D		No	Ensembl
rs2128643880	1355	A>V		No	Ensembl
rs1779340755	1357	A>P		No	TOPMed
rs1779340755	1357	A>T		No	TOPMed
rs1188265810	1358	Q>L		No	TOPMed gnomAD
rs1188265810	1358	Q>R		No	TOPMed gnomAD
rs760464623	1359	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1779339431	1359	E>G		No	TOPMed
rs775283285	1360	I>F		No	ExAC gnomAD
rs2128643816	1360	I>M		No	Ensembl
rs2128643800	1361	W>L		No	Ensembl
rs1361880790	1361	W>R		No	TOPMed gnomAD
rs2128643795	1362	A>G		No	Ensembl
rs1226824505	1363	M>I		No	TOPMed gnomAD
rs1249622633	1363	M>V		No	TOPMed gnomAD
rs2128643786	1364	D>N		No	Ensembl
rs372697979	1365	L>V		No	ESP TOPMed gnomAD
COSM1731133 rs759998400 COSM1731132	1366	E>*	liver [Cosmic]	No	cosmic curated ExAC gnomAD
rs1562308913	1366	E>G		No	Ensembl
rs759998400	1366	E>Q		No	ExAC gnomAD
rs1304190335	1367	G>D		No	TOPMed gnomAD
rs1304190335	1367	G>V		No	TOPMed gnomAD
rs949132311	1368	C>S		No	TOPMed gnomAD
rs774895292	1368	C>S		No	ExAC gnomAD
rs949132311	1368	C>Y		No	TOPMed gnomAD
rs2128643708	1369	Q>E		No	Ensembl
rs771382014	1369	Q>H		No	ExAC gnomAD
rs1373192508	1370	C>F		No	gnomAD
rs36106063 VAR_041453	1370	C>R		No	UniProt Ensembl dbSNP
rs1373192508	1370	C>S		No	gnomAD
rs1373192508	1370	C>Y		No	gnomAD
rs2128643672	1371	W>L		No	Ensembl
rs200679820	1372	R>*		No	1000Genomes ExAC TOPMed gnomAD
rs200679820	1372	R>G		No	1000Genomes ExAC TOPMed gnomAD
COSM1544589 COSM1663954	1374	I>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs773222044	1375	T>I		No	ExAC gnomAD
rs773222044	1375	T>R		No	ExAC gnomAD
rs769929206	1376	V>A		No	ExAC TOPMed gnomAD
rs2128643651	1376	V>I		No	Ensembl
rs368568897	1377	P>A		No	ESP ExAC TOPMed gnomAD
rs781424868	1377	P>L		No	ExAC TOPMed gnomAD
rs781424868	1377	P>R		No	ExAC TOPMed gnomAD
rs368568897	1377	P>S		No	ESP ExAC TOPMed gnomAD
rs2128643619	1378	A>T		No	Ensembl
rs758140275	1379	M>I		No	ExAC TOPMed gnomAD
rs1248711517	1379	M>V		No	gnomAD
rs745716185	1380	L>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs2128643606	1380	L>V		No	Ensembl
rs779854799	1381	A>P		No	ExAC gnomAD
rs779854799	1381	A>T		No	ExAC gnomAD
rs746109140	1383	K>E		No	Ensembl
rs754735161	1383	K>I		No	ExAC gnomAD
rs183156700	1384	T>P		No	1000Genomes ExAC gnomAD
COSM3619843 COSM3619842	1384	T>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs766583476	1385	L>I		No	ExAC gnomAD
rs763408577	1386	V>I		No	ExAC gnomAD
rs1396897004	1387	S>N		No	TOPMed gnomAD
rs1396897004	1387	S>T		No	TOPMed gnomAD
rs2128638276	1389	T>I		No	Ensembl
rs1444059505	1389	T>P		No	gnomAD
rs1243900066	1390	V>M		No	gnomAD
rs750846787	1391	D>V		No	ExAC TOPMed gnomAD
rs1206111595	1391	D>Y		No	gnomAD
rs2128638237	1392	G>E		No	Ensembl
rs891479903	1392	G>R		No	Ensembl
rs765782172	1393	D>E		No	ExAC TOPMed gnomAD
TCGA novel rs1779016748	1393	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1405707094	1393	D>V		No	TOPMed gnomAD
rs1206124997	1394	L>F		No	TOPMed gnomAD
rs1206124997	1394	L>I		No	TOPMed gnomAD
rs1052769795	1394	L>P		No	TOPMed gnomAD
rs1206124997	1394	L>V		No	TOPMed gnomAD
rs1779015011	1395	I>M		No	TOPMed gnomAD
rs1779014775	1396	Y>H		No	Ensembl
rs1287692177	1397	W>*		No	gnomAD
rs761853713	1397	W>R		No	ExAC gnomAD
rs1381396919	1400	T>R		No	gnomAD
rs2128638141	1401	A>T		No	Ensembl
rs138678303	1402	K>E		No	ESP ExAC gnomAD
rs1779012704	1403	D>G		No	TOPMed
rs2128638128	1403	D>H		No	Ensembl
rs1779012416	1404	S>I		No	TOPMed
rs1779012416	1404	S>N		No	TOPMed
rs150274045	1405	T>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs770579061	1405	T>I		No	ExAC gnomAD
rs770579061	1405	T>R		No	ExAC gnomAD
rs1469221153	1406	Q>H		No	TOPMed gnomAD
rs1779011487	1406	Q>R		No	TOPMed gnomAD
rs1207686047	1408	Y>N		No	TOPMed gnomAD
rs2128638072	1409	Q>*		No	Ensembl
rs2128638057	1409	Q>H		No	Ensembl
rs2128638066	1409	Q>R		No	Ensembl
rs1582710410	1410	A>E		No	Ensembl
rs2128638048	1410	A>T		No	Ensembl
rs1217876302	1412	K>Q		No	gnomAD
rs2128637999	1413	G>A		No	Ensembl
COSM1697829 rs2128637999 COSM1697830	1413	G>E	Variant assessed as Somatic; MODERATE impact. skin [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs928456849	1413	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
TCGA novel	1415	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128637993	1415	G>W		No	Ensembl
rs2128637968	1416	A>G		No	Ensembl
TCGA novel	1416	A>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2128637975	1416	A>S		No	Ensembl
rs2128637975	1416	A>T		No	Ensembl
rs2128637968	1416	A>V		No	Ensembl
TCGA novel	1418	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs777817381	1418	V>I		No	ExAC TOPMed gnomAD
rs1385882714	1419	S>C		No	gnomAD
rs1385882714	1419	S>F		No	gnomAD
rs1183678053	1420	Q>H		No	gnomAD
rs1779007923	1421	V>A		No	TOPMed
rs2128637922	1421	V>M		No	Ensembl
rs2128637905	1422	K>M		No	Ensembl
COSM3857801 COSM3857802	1422	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1418282255	1423	A>G		No	TOPMed gnomAD
rs374701749	1423	A>T		No	ESP ExAC TOPMed gnomAD
rs1418282255	1423	A>V		No	TOPMed gnomAD
rs2128637865	1425	R>T		No	Ensembl
rs1779006730	1425	R>W		No	Ensembl
rs1779006296	1426	S>N		No	Ensembl
rs1779006110	1426	S>R		No	TOPMed
rs2128637833	1428	H>Q		No	Ensembl
rs1779005905	1429	I>V		No	TOPMed
rs1358301021	1431	A>G		No	TOPMed gnomAD
rs1312975656	1431	A>P		No	gnomAD
rs1312975656	1431	A>T		No	gnomAD
rs1358301021	1431	A>V		No	TOPMed gnomAD
rs1779004353	1432	Y>C		No	gnomAD
rs867268246	1432	Y>H		No	Ensembl
rs751133474	1433	S>G		No	ExAC TOPMed gnomAD
rs2128637776	1433	S>N		No	Ensembl
rs2128637774	1434	S>*		No	Ensembl
rs2128637767	1435	V>I		No	Ensembl
rs779780358	1436	M>I		No	ExAC TOPMed gnomAD
rs1229565223	1436	M>T		No	gnomAD
rs2128637733	1437	Q>*		No	Ensembl
rs1779003031	1437	Q>R		No	Ensembl
rs758668577	1438	P>A		No	ExAC gnomAD
rs948632310	1438	P>R		No	TOPMed gnomAD
VAR_030651 rs17079086	1439	F>S		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs765733079 COSM1697828 COSM1697827	1440	P>L	skin [Cosmic]	No	cosmic curated ExAC gnomAD
COSM1072557 rs867084033 COSM3157753 COSM1072555	1440	P>S	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic Ensembl NCI-TCGA
rs147732228	1441	D>G		No	ESP ExAC TOPMed gnomAD
rs2128637679	1441	D>N		No	Ensembl
rs2128637679	1441	D>Y		No	Ensembl
rs2128626380	1442	K>N		No	Ensembl
rs376021394	1443	A>E		No	ExAC TOPMed gnomAD
rs376021394	1443	A>G		No	ExAC TOPMed gnomAD
rs1452299600	1443	A>T		No	TOPMed
rs376021394	1443	A>V		No	ExAC TOPMed gnomAD
rs2128626356	1444	F>C		No	Ensembl
COSM1645904 COSM483324	1445	L>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1480952819	1446	S>F		No	gnomAD
rs2128626335	1447	L>P		No	Ensembl
TCGA novel	1447	L>Q	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs756112469	1447	L>V		No	ExAC
rs1435575705	1448	A>V		No	TOPMed
rs752884684	1450	D>G		No	ExAC TOPMed gnomAD
rs752884684	1450	D>V		No	ExAC TOPMed gnomAD
COSM3429912 COSM3429911	1450	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1192560596	1451	T>A		No	TOPMed gnomAD
rs1192560596	1451	T>S		No	TOPMed gnomAD
rs1778188118	1452	V>M		No	TOPMed
rs2128626289	1453	E>G		No	Ensembl
rs2128626295	1453	E>Q		No	Ensembl
rs2128626281	1454	P>A		No	Ensembl
rs2128626275	1454	P>L		No	Ensembl
rs2128626281	1454	P>S		No	Ensembl
rs767620506	1455	T>A		No	ExAC gnomAD
rs2128626262	1455	T>I		No	Ensembl
rs1231753858	1456	I>T		No	TOPMed gnomAD
rs759746491	1457	L>V		No	ExAC gnomAD
rs2128626226	1459	A>P		No	Ensembl
rs2128626226	1459	A>S		No	Ensembl
COSM739499 COSM1647876	1459	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs765083865	1459	A>V		No	ExAC TOPMed gnomAD
rs761724280	1462	T>A		No	ExAC TOPMed gnomAD
rs1312553343	1463	S>N		No	TOPMed gnomAD
rs1778183426	1464	L>I		No	TOPMed
rs1303212090	1465	T>A		No	gnomAD
TCGA novel	1466	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs551574654	1467	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs2128626167	1468	L>F		No	Ensembl
rs533175529	1469	P>L		No	1000Genomes TOPMed gnomAD
rs533175529	1469	P>R		No	1000Genomes TOPMed gnomAD
rs746497124	1470	L>R		No	ExAC gnomAD
rs1404057865	1471	A>T		No	TOPMed gnomAD
rs1778181537	1473	T>P		No	TOPMed
rs1308794945	1474	N>D		No	TOPMed gnomAD
rs963068602	1475	L>I		No	TOPMed gnomAD
rs1046794283	1477	W>*		No	TOPMed gnomAD
rs929759630	1477	W>*		No	Ensembl
rs929759630	1477	W>C		No	Ensembl
rs1046794283	1477	W>L		No	TOPMed gnomAD
rs1046794283	1477	W>S		No	TOPMed gnomAD
TCGA novel	1478	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs745459533	1479	G>D		No	ExAC TOPMed gnomAD
rs745459533	1479	G>V		No	ExAC TOPMed gnomAD
rs1240801198	1480	I>M		No	TOPMed gnomAD
rs1182896315	1481	T>N		No	gnomAD
rs757592384	1482	S>G		No	ExAC gnomAD
rs1257469550	1482	S>N		No	gnomAD
rs749689925	1483	P>R		No	ExAC gnomAD
rs922427037	1484	T>I		No	Ensembl
rs2128626024	1485	P>A		No	Ensembl
rs2128626020	1485	P>Q		No	Ensembl
rs2128626024	1485	P>T		No	Ensembl
rs1040880336	1487	Y>C		No	TOPMed gnomAD
rs1286980491	1487	Y>H		No	gnomAD
COSM1544591 rs1562294207 COSM6172038 COSM1544590 COSM6172037	1489	V>F	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic gnomAD
rs1562294207	1489	V>I		No	gnomAD
rs753157680	1490	Y>H		No	ExAC TOPMed gnomAD
rs373575161	1491	Y>C		No	ESP ExAC TOPMed gnomAD
rs2128625969	1492	A>E		No	Ensembl
rs2128625978	1492	A>T		No	Ensembl
TCGA novel	1493	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs151172982	1493	E>G		No	ESP ExAC gnomAD
rs142098208	1494	V>A		No	ESP ExAC TOPMed gnomAD
rs142098208	1494	V>G		No	ESP ExAC TOPMed gnomAD
rs766758100 COSM72473	1495	N>D	ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM1440060 COSM1440061 rs1778174340	1495	N>S	large_intestine [Cosmic]	No	cosmic curated TOPMed
rs1778173843	1496	D>E		No	gnomAD
rs1158871186	1496	D>Y		No	gnomAD
rs1778173601	1497	R>G		No	TOPMed
rs1278804712	1498	K>*		No	gnomAD
TCGA novel	1499	N>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1778172885	1500	S>G		No	gnomAD
rs148612298	1501	S>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1226545186	1502	D>E		No	gnomAD
rs1421203380	1502	D>G		No	TOPMed gnomAD
rs958026755	1505	Y>C		No	TOPMed gnomAD
rs143849918	1505	Y>H		No	ESP TOPMed gnomAD
RCV000956407 VAR_041454 rs35841892	1506	R>G		No	ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1258207555	1506	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1258207555	1506	R>K		No	gnomAD
rs1258207555	1506	R>T		No	gnomAD
rs1489503636 COSM4548633 COSM4548632	1509	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1489503636	1509	E>Q		No	TOPMed gnomAD
rs1371845070	1511	Q>R		No	TOPMed gnomAD
rs1778029096	1512	D>E		No	gnomAD
rs1778029433	1512	D>G		No	gnomAD
rs1778029784	1512	D>N		No	Ensembl
rs1227267213	1513	S>N		No	TOPMed gnomAD
COSM483321 COSM483322 COSM1645905 rs1778028516	1514	I>M	kidney [Cosmic]	No	cosmic curated gnomAD
rs1778028168	1515	A>P		No	1000Genomes
rs1778028168	1515	A>S		No	1000Genomes
rs2128624110	1515	A>V		No	Ensembl
rs770437430	1517	I>T		No	ExAC
rs866401304	1518	E>*		No	Ensembl
rs866401304	1518	E>K		No	Ensembl
rs762524687	1519	D>N		No	ExAC gnomAD
TCGA novel	1519	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs139406677	1520	L>F		No	ESP TOPMed gnomAD
rs910993051	1520	L>S		No	TOPMed gnomAD
rs2128624067	1521	Q>*		No	Ensembl
rs112739824	1522	P>L		No	ESP ExAC TOPMed gnomAD
rs112739824	1522	P>Q		No	ESP ExAC TOPMed gnomAD
rs772770962	1522	P>T		No	ExAC
rs1778024048	1523	F>KK*		No	Ensembl
rs986408985	1524	S>L		No	TOPMed gnomAD
rs1345318306	1525	T>A		No	TOPMed
rs141763354	1525	T>R		No	ESP ExAC TOPMed gnomAD
rs925004365	1526	Y>C		No	gnomAD
rs138573193	1526	Y>D		No	ESP ExAC TOPMed gnomAD
rs138573193	1526	Y>H		No	ESP ExAC TOPMed gnomAD
rs138573193	1526	Y>N		No	ESP ExAC TOPMed gnomAD
rs1778022335	1527	M>I		No	TOPMed gnomAD
rs369511700	1527	M>L		No	ESP ExAC TOPMed gnomAD
rs369511700	1527	M>V		No	ESP ExAC TOPMed gnomAD
TCGA novel	1528	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs780225613	1528	I>V		No	ExAC gnomAD
rs758560276	1529	Q>*		No	ExAC TOPMed gnomAD
rs2128623984	1529	Q>H		No	Ensembl
rs750621559	1529	Q>R		No	ExAC TOPMed gnomAD
rs374813403	1530	I>M		No	ESP TOPMed gnomAD
rs1778021494	1530	I>T		No	gnomAD
rs1017338335	1531	A>G		No	TOPMed
rs531086338	1531	A>T		No	1000Genomes ExAC gnomAD
rs1017338335	1531	A>V		No	TOPMed
rs2128623953	1532	V>I		No	Ensembl
rs2128623953	1532	V>L		No	Ensembl
rs755903627	1533	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs776274768 RCV000736226	1534	N>missing		No	ClinVar dbSNP
rs776274768	1534	N>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs776274768	1534	N>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs979161310	1534	N>S		No	Ensembl
TCGA novel	1535	Y>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1199837770	1536	Y>F		No	gnomAD
rs752499456	1537	S>L		No	ExAC gnomAD
rs754848627	1538	D>E		No	ExAC TOPMed gnomAD
rs2128623886	1538	D>H		No	Ensembl
rs373022618	1538	D>V		No	ESP ExAC TOPMed gnomAD
rs1185119698	1539	P>H		No	TOPMed
COSM3619839 rs751502071 COSM3619838	1539	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs762390077	1541	E>D		No	ExAC gnomAD
rs202169003	1541	E>K		No	1000Genomes ExAC gnomAD
rs1459609360	1542	H>Y		No	TOPMed
rs1778015572	1544	P>T		No	TOPMed
rs772896918	1545	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
COSM4549053 COSM1072550	1546	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128623830	1546	G>V		No	Ensembl
rs1033731821	1547	K>E		No	TOPMed gnomAD
rs542373889	1548	E>Q		No	1000Genomes ExAC
rs776919099	1549	I>T		No	ExAC gnomAD
rs150147295	1549	I>V		No	1000Genomes ExAC gnomAD
rs561775569	1550	W>*		No	1000Genomes ExAC gnomAD
rs2128623789	1550	W>C		No	Ensembl
rs561775569	1550	W>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA gnomAD
COSM739500 COSM739501 rs1417876029 COSM1647877	1551	G>E	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs776176321	1551	G>R		No	ExAC gnomAD
rs772231643	1552	K>N		No	ExAC gnomAD
TCGA novel	1552	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs745987821	1554	K>E		No	ExAC gnomAD
rs779188243	1555	N>S		No	ExAC TOPMed gnomAD
rs779188243	1555	N>T		No	ExAC TOPMed gnomAD
rs1362301601	1556	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
COSM1645906 rs150852319 COSM1137420 COSM1137419	1557	V>I	kidney [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs2128622807	1559	E>V		No	Ensembl
rs2128622798	1562	Q>*		No	Ensembl
rs779963365	1563	L>P		No	ExAC TOPMed gnomAD
rs1562291174	1567	T>I		No	Ensembl
rs2128622769	1568	V>M		No	Ensembl
rs141448347	1569	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141448347 COSM3857799 COSM3857800	1569	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
COSM3920639 COSM3920640 rs199762082	1569	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs1284677397	1570	S>L		No	gnomAD
rs192730088	1570	S>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs192730088	1570	S>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1582673789	1571	D>A		No	Ensembl
rs1582673754	1572	T>P		No	Ensembl
rs1562291079 COSM1440058 COSM4786714 COSM1440059	1573	S>N	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic Ensembl NCI-TCGA
rs1324451226	1573	S>R		No	TOPMed gnomAD
rs761092844	1575	I>T		No	ExAC gnomAD
rs763892419	1575	I>V		No	ExAC gnomAD
rs767933411	1576	I>T		No	ExAC gnomAD
rs200762545	1576	I>V		No	1000Genomes ExAC TOPMed gnomAD
rs1404812280	1577	S>C		No	gnomAD
rs1278454013	1577	S>P		No	TOPMed gnomAD
rs770865174	1578	W>*		No	ExAC TOPMed gnomAD
rs759890825	1578	W>*		No	ExAC
rs770865174	1578	W>C		No	ExAC TOPMed gnomAD
rs1165438791	1578	W>R		No	TOPMed gnomAD
rs2128622663	1579	R>*		No	Ensembl
rs1777928810 COSM3619837 COSM3619836	1579	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs763067644	1580	E>G		No	ExAC
rs1165495915	1580	E>K		No	gnomAD
rs763067644	1580	E>V		No	ExAC
COSM1311504 COSM4811450	1581	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1474721113	1581	S>F		No	gnomAD
rs1423277535	1582	H>Y		No	TOPMed gnomAD
rs773391483	1583	K>N		No	ExAC gnomAD
rs2128622627	1584	P>S		No	Ensembl
rs531832845	1586	G>E		No	TOPMed
rs2128622622	1586	G>R		No	Ensembl
rs2128622599	1587	P>A		No	Ensembl
rs1264849617	1587	P>L		No	TOPMed gnomAD
rs2128622599	1587	P>S		No	Ensembl
COSM1440057 COSM4948447	1589	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1777925811	1591	V>F		No	Ensembl
rs1777925811	1591	V>I		No	Ensembl
rs368206665	1592	R>C		No	ExAC gnomAD
rs148310006	1592	R>H		No	ESP ExAC gnomAD
rs148310006	1592	R>P		No	ESP ExAC gnomAD
rs368206665	1592	R>S		No	ExAC gnomAD
rs1337370599	1593	Y>F		No	TOPMed gnomAD
COSM5869181 COSM5869182 rs2128622556	1594	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1018937624	1594	Q>H		No	Ensembl
rs1777923516	1595	L>*		No	Ensembl
rs3752564	1595	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128622524	1596	A>S		No	Ensembl
rs2128622524	1596	A>T		No	Ensembl
rs2128622520	1596	A>V		No	Ensembl
rs1342190901	1597	I>*		No	gnomAD
rs1281612889	1597	I>V		No	TOPMed gnomAD
rs1436107648	1600	L>P		No	gnomAD
rs45439298	1601	A>D		No	1000Genomes ExAC TOPMed gnomAD
rs1777922068	1601	A>P		No	TOPMed
rs1777922068	1601	A>T		No	TOPMed
TCGA novel	1601	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1408672277	1604	P>S		No	TOPMed gnomAD
rs547983474	1605	E>Q		No	1000Genomes ExAC TOPMed gnomAD
rs1172074849	1606	T>A		No	gnomAD
TCGA novel rs2128622474	1606	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
COSM3619834 COSM3619835	1607	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs753442951	1607	P>S		No	ExAC gnomAD
rs143210953	1608	L>V		No	ExAC gnomAD
rs1291943165	1609	R>*		No	TOPMed gnomAD
rs1477497007	1609	R>K		No	gnomAD
rs1777918988	1611	S>N		No	Ensembl
TCGA novel	1612	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1777918629	1612	E>K		No	TOPMed
rs755766404	1614	P>L		No	ExAC TOPMed gnomAD
COSM3619832 COSM3619833	1614	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1456345928	1615	N>D		No	gnomAD
rs1777916721	1615	N>S		No	Ensembl
rs751986538	1617	R>S		No	ExAC TOPMed gnomAD
rs1319726072	1618	L>H		No	gnomAD
rs1319726072	1618	L>P		No	gnomAD
rs2128622392	1619	T>I		No	Ensembl
rs146668165	1620	L>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1777913566	1620	L>H		No	TOPMed
rs1777913249	1621	L>V		No	Ensembl
rs1777912886	1622	V>I		No	Ensembl
rs773338439	1623	T>N		No	ExAC gnomAD
rs769875440	1625	L>V		No	ExAC TOPMed gnomAD
COSM323108 COSM323109 rs142109327	1626	S>C	lung [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs142109327	1626	S>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1010526451	1626	S>P		No	Ensembl
rs2128622328	1627	G>C		No	Ensembl
COSM3619831 COSM3619830	1627	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128622328	1627	G>S		No	Ensembl
rs2128622317	1627	G>V		No	Ensembl
rs2128622310	1628	G>V		No	Ensembl
rs1264334742	1631	Y>C		No	TOPMed gnomAD
rs776944811	1631	Y>H		No	ExAC TOPMed gnomAD
rs1777908292	1632	V>A		No	gnomAD
rs1777908539	1632	V>M		No	Ensembl
rs2128622134	1635	V>D		No	Ensembl
rs765279582	1635	V>F		No	TOPMed gnomAD
rs765279582	1635	V>I		No	TOPMed gnomAD
rs370393953	1636	L>F		No	ESP ExAC TOPMed gnomAD
rs370393953	1636	L>I		No	ESP ExAC TOPMed gnomAD
rs367999236	1637	A>D		No	TOPMed gnomAD
rs367999236	1637	A>G		No	TOPMed gnomAD
rs1361333016	1637	A>P		No	gnomAD
rs367999236	1637	A>V		No	TOPMed gnomAD
rs1417503410	1638	C>*		No	gnomAD
rs147104879	1638	C>F		No	ESP ExAC TOPMed gnomAD
rs147104879	1638	C>S		No	ESP ExAC TOPMed gnomAD
rs2128622111	1638	C>S		No	Ensembl
rs147104879	1638	C>Y		No	ESP ExAC TOPMed gnomAD
rs1379084378	1639	H>L		No	gnomAD
rs768081803	1639	H>Q		No	TOPMed gnomAD
rs1379084378	1639	H>R		No	gnomAD
COSM1316562 COSM1316561 rs2128622094	1639	H>Y	haematopoietic_and_lymphoid_tissue [Cosmic]	No	cosmic curated Ensembl
rs937896470	1640	S>A		No	TOPMed
rs1441413725	1640	S>C		No	TOPMed gnomAD
rs1441413725	1640	S>F		No	TOPMed gnomAD
rs2128622058	1641	E>D		No	Ensembl
rs2128622064	1641	E>K		No	Ensembl
rs2128622064	1641	E>Q		No	Ensembl
rs2128622046	1642	E>*		No	Ensembl
rs758846560	1642	E>D		No	ExAC TOPMed gnomAD
COSM1697823 COSM1697824 rs2128622046	1642	E>K	NS Variant assessed as Somatic; MODERATE impact. skin [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs2128622046	1642	E>Q		No	Ensembl
rs1260462127	1643	M>I		No	TOPMed
rs1181248171	1643	M>V		No	TOPMed gnomAD
rs750934790	1644	W>C		No	ExAC TOPMed gnomAD
TCGA novel rs1777893903	1644	W>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs2128622023	1644	W>L		No	Ensembl
rs1777893903	1644	W>R		No	TOPMed gnomAD
rs2128621999	1645	C>*		No	Ensembl
rs765262539	1645	C>F		No	ExAC gnomAD
rs1777893244	1645	C>R		No	TOPMed gnomAD
rs2128621999	1645	C>W		No	Ensembl
rs765262539	1645	C>Y		No	ExAC gnomAD
rs761904834	1646	T>A		No	ExAC TOPMed gnomAD
rs1046359018	1646	T>I		No	TOPMed gnomAD
rs761904834	1646	T>S		No	ExAC TOPMed gnomAD
rs2128621977	1647	E>D		No	Ensembl
rs2128621986	1647	E>Q		No	Ensembl
rs2128621983	1647	E>V		No	Ensembl
rs764420063	1648	S>C		No	ExAC TOPMed gnomAD
rs764420063	1648	S>G		No	ExAC TOPMed gnomAD
rs1421889146	1648	S>N		No	TOPMed gnomAD
rs2128621959	1648	S>R		No	Ensembl
rs1242429496	1649	H>N		No	gnomAD
rs2128621953	1649	H>R		No	Ensembl
rs1242429496	1649	H>Y		No	gnomAD
rs1320046867	1650	P>A		No	TOPMed gnomAD
rs201532881	1650	P>L		No	1000Genomes TOPMed gnomAD
rs201532881	1650	P>R		No	1000Genomes TOPMed gnomAD
rs1320046867	1650	P>S		No	TOPMed gnomAD
rs1320046867	1650	P>T		No	TOPMed gnomAD
rs2128621922	1651	V>D		No	Ensembl
rs1777890523	1651	V>F		No	TOPMed
rs1777890523	1651	V>I		No	TOPMed
rs1777890523	1651	V>L		No	TOPMed
TCGA novel	1652	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128621899	1652	T>I		No	Ensembl
rs1562290184	1652	T>P		No	Ensembl
rs1562290184	1652	T>S		No	Ensembl
rs2128621899	1652	T>S		No	Ensembl
rs1472359289	1653	V>A		No	TOPMed gnomAD
rs1472359289	1653	V>E		No	TOPMed gnomAD
rs1472359289	1653	V>G		No	TOPMed gnomAD
rs2128621887	1653	V>L		No	Ensembl
rs2128621887	1653	V>M		No	Ensembl
rs2128621858	1654	E>*		No	Ensembl
rs2128621858	1654	E>K		No	Ensembl
rs2128621858	1654	E>Q		No	Ensembl
rs2128621849	1655	M>I		No	Ensembl
rs2128621853	1655	M>K		No	Ensembl
rs2128621856	1655	M>V		No	Ensembl
rs2128621843	1656	F>I		No	Ensembl
rs2128621831	1656	F>L		No	Ensembl
rs2128621836	1656	F>S		No	Ensembl
rs2128621836	1656	F>Y		No	Ensembl
rs2128621825	1657	N>I		No	Ensembl
rs2128621815	1657	N>K		No	Ensembl
rs2128621799	1658	T>I		No	Ensembl
rs2128621799	1658	T>R		No	Ensembl
rs2128621808	1658	T>S		No	Ensembl
rs184429367	1659	P>A		No	1000Genomes ExAC TOPMed gnomAD
rs1359523756	1659	P>L		No	gnomAD
rs1359523756	1659	P>R		No	gnomAD
rs184429367	1659	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs184429367 RCV000963035	1659	P>T		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs2128621770	1660	E>*		No	Ensembl
rs2128621755	1660	E>D		No	Ensembl
rs2128621765	1660	E>G		No	Ensembl
rs2128621770	1660	E>K		No	Ensembl
rs2128621770	1660	E>Q		No	Ensembl
rs1468695285	1661	K>N		No	gnomAD
COSM3828891 COSM3828892	1661	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1777888433	1661	K>R		No	TOPMed
rs1777888433	1661	K>T		No	TOPMed
rs141772440	1662	P>A		No	ESP ExAC gnomAD
rs769404232	1662	P>H		No	ExAC gnomAD
rs769404232	1662	P>L		No	ExAC gnomAD
rs769404232	1662	P>R		No	ExAC gnomAD
rs141772440	1662	P>S		No	ESP ExAC gnomAD
rs754717204	1663	Y>*		No	ExAC gnomAD
rs2128621714	1663	Y>N		No	Ensembl
rs1777886627	1664	S>C		No	TOPMed
rs1777886627	1664	S>F		No	TOPMed
rs1777886627	1664	S>Y		No	TOPMed
rs2128621682	1665	L>*		No	Ensembl
rs780398903	1665	L>F		No	ExAC TOPMed gnomAD
rs2128621686	1665	L>M		No	Ensembl
rs2128621661	1666	V>D		No	Ensembl
rs758795675	1666	V>F		No	ExAC gnomAD
COSM35766 rs758795675 COSM1559726	1666	V>I	central_nervous_system [Cosmic]	No	cosmic curated ExAC gnomAD
rs758795675	1666	V>L		No	ExAC gnomAD
rs1777885821	1667	P>A		No	Ensembl
rs866472077 COSM3857795 COSM3857796	1667	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
rs866472077	1667	P>R		No	Ensembl
rs1777885821	1667	P>T		No	Ensembl
rs2128621626	1668	E>*		No	Ensembl
rs145788522	1668	E>D		No	ESP ExAC TOPMed gnomAD
rs2128621626	1668	E>K		No	Ensembl
rs2128621626	1668	E>Q		No	Ensembl
rs2128621616	1669	N>D		No	Ensembl
rs2128621612	1669	N>I		No	Ensembl
rs2128621616	1669	N>Y		No	Ensembl
rs1360437041	1670	T>A		No	TOPMed
rs1360437041	1670	T>S		No	TOPMed
rs2128621604	1670	T>S		No	Ensembl
rs1191272034	1671	S>C		No	gnomAD
rs149694844	1671	S>N		No	ESP
rs2128621584	1671	S>R		No	Ensembl
rs149694844	1671	S>T		No	ESP
rs1280459437	1672	L>F		No	TOPMed gnomAD
rs2128621570	1673	Q>*		No	Ensembl
rs2128621570	1673	Q>E		No	Ensembl
rs2128621557	1673	Q>H		No	Ensembl
rs2128621565	1673	Q>R		No	Ensembl
rs2128621552	1674	F>I		No	Ensembl
rs1264140574	1674	F>L		No	gnomAD
rs2128621547	1674	F>Y		No	Ensembl
rs2128621528	1675	N>I		No	Ensembl
rs757298192	1675	N>K		No	ExAC
rs2128621528	1675	N>S		No	Ensembl
rs1777883679	1675	N>Y		No	TOPMed
rs2128621515	1676	W>*		No	Ensembl
rs1777883048	1676	W>*		No	Ensembl
rs2128621515	1676	W>C		No	Ensembl
rs1777883048	1676	W>L		No	Ensembl
rs754020828	1676	W>R		No	ExAC gnomAD
rs2128621507	1677	K>M		No	Ensembl
rs2128621502	1677	K>N		No	Ensembl
rs2128621507	1677	K>R		No	Ensembl
rs1283157285	1678	A>D		No	gnomAD
rs1283157285	1678	A>G		No	gnomAD
rs2128621492	1678	A>P		No	Ensembl
rs2128621492	1678	A>S		No	Ensembl
rs2128621492	1678	A>T		No	Ensembl
rs1283157285	1678	A>V		No	gnomAD
rs764212412	1679	P>A		No	ExAC TOPMed gnomAD
rs764212412	1679	P>S		No	ExAC TOPMed gnomAD
rs764212412	1679	P>T		No	ExAC TOPMed gnomAD
rs2128621454	1680	L>*		No	Ensembl
rs2128621447	1680	L>F		No	Ensembl
rs1725767255	1680	L>M		No	gnomAD
rs2128621454	1680	L>S		No	Ensembl
rs2128621442	1681	N>D		No	Ensembl
rs760880286	1681	N>I		No	ExAC gnomAD
rs762297422	1681	N>K		No	Ensembl
rs2128621428	1682	V>D		No	Ensembl
COSM739502 COSM1647878 rs2128621434 COSM739503	1682	V>F	lung [Cosmic]	No	cosmic curated Ensembl
rs2128621434	1682	V>I		No	Ensembl
rs2128621434	1682	V>L		No	Ensembl
rs1777881454	1683	N>D		No	TOPMed
rs1281997419	1683	N>I		No	TOPMed gnomAD
rs2128621415	1683	N>K		No	Ensembl
rs1281997419	1683	N>S		No	TOPMed gnomAD
rs2128621411	1684	L>F		No	Ensembl
rs2128621402	1684	L>H		No	Ensembl
rs2128621411	1684	L>I		No	Ensembl
rs2128621402	1684	L>P		No	Ensembl
rs775601610	1685	I>L		No	ExAC TOPMed gnomAD
rs2128621382	1685	I>M		No	Ensembl
rs575473741	1685	I>N		No	Ensembl
rs575473741	1685	I>T		No	Ensembl
rs2128621374	1686	R>K		No	Ensembl
rs2128621374	1686	R>T		No	Ensembl
rs2128621362	1687	F>L		No	Ensembl
rs2128621366	1687	F>Y		No	Ensembl
TCGA novel	1688	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2128621358	1688	W>G		No	Ensembl
rs766225570	1689	V>A		No	ExAC TOPMed gnomAD
rs766225570	1689	V>D		No	ExAC TOPMed gnomAD
rs2128621355	1689	V>I		No	Ensembl
rs1278432974	1690	E>K		No	TOPMed gnomAD
rs1278432974	1690	E>Q		No	TOPMed gnomAD
rs2128621342	1690	E>V		No	Ensembl
rs1777879636	1691	L>I		No	Ensembl
rs2128621331	1691	L>Q		No	Ensembl
rs1777879636	1691	L>V		No	Ensembl
rs2128621325	1692	Q>*		No	Ensembl
rs2128621325	1692	Q>E		No	Ensembl
TCGA novel rs2128621318	1692	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs140772370	1692	Q>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs140772370	1692	Q>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128621311	1693	K>E		No	Ensembl
rs2128621305	1693	K>N		No	Ensembl
rs2128621309	1693	K>R		No	Ensembl
rs2128617409 COSM1487171 COSM1487172	1694	W>*	breast [Cosmic]	No	cosmic curated Ensembl
rs2128617400 COSM4813176 COSM1487172 COSM4813177 COSM1487171	1694	W>*	Variant assessed as Somatic; HIGH impact. breast [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic Ensembl
rs2128617400	1694	W>C		No	Ensembl
rs112475836	1694	W>R		No	Ensembl
rs2128617409	1694	W>S		No	Ensembl
rs2128617393	1695	K>N		No	Ensembl
rs762836563	1696	Y>*		No	ExAC gnomAD
rs1777560244	1696	Y>D		No	TOPMed gnomAD
rs2128617385	1696	Y>F		No	Ensembl
rs1777560244	1696	Y>N		No	TOPMed gnomAD
rs750301229	1697	N>D		No	ExAC gnomAD
rs2128617372	1697	N>I		No	Ensembl
rs765137339	1697	N>K		No	ExAC TOPMed gnomAD
rs750301229	1697	N>Y		No	ExAC gnomAD
rs2128617359	1698	E>*		No	Ensembl
rs2128617359	1698	E>K		No	Ensembl
rs2128617359	1698	E>Q		No	Ensembl
rs2128617355	1698	E>V		No	Ensembl
rs2128617346	1699	F>I		No	Ensembl
rs2128617346	1699	F>V		No	Ensembl
rs2128617339	1699	F>Y		No	Ensembl
rs2128617330	1700	Y>*		No	Ensembl
rs1400675993	1701	H>D		No	TOPMed gnomAD
rs1400675993	1701	H>N		No	TOPMed gnomAD
rs2128617320	1701	H>Q		No	Ensembl
rs1172596225	1701	H>R		No	gnomAD
rs1400675993	1701	H>Y		No	TOPMed gnomAD
rs776465526	1702	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs776465526	1702	V>D		No	ExAC TOPMed gnomAD
rs776465526	1702	V>G		No	ExAC TOPMed gnomAD
rs2128617316	1702	V>I		No	Ensembl
rs2128617316	1702	V>L		No	Ensembl
rs1777556873	1703	K>E		No	gnomAD
rs2128617301	1703	K>I		No	Ensembl
rs2128617294	1703	K>N		No	Ensembl
rs2128617291	1704	T>S		No	Ensembl
rs2128617279	1705	S>*		No	Ensembl
COSM4852720 COSM1720290 rs2128617279 COSM1720291	1705	S>L	NS Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs771782242	1706	C>*		No	ExAC gnomAD
TCGA novel	1706	C>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs143981354	1706	C>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs143981354	1706	C>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128617264	1706	C>S		No	Ensembl
rs771782242	1706	C>W		No	ExAC gnomAD
rs2128617264	1706	C>Y		No	Ensembl
rs1777555169	1707	S>C		No	TOPMed
rs2128617250	1707	S>I		No	Ensembl
COSM3157723 COSM3157724 rs2128617250 COSM3619829	1707	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1777554857	1707	S>R		No	gnomAD
rs2128617250	1707	S>T		No	Ensembl
rs546018658	1708	Q>*		No	1000Genomes ExAC gnomAD
rs546018658	1708	Q>E		No	1000Genomes ExAC gnomAD
rs2128617236	1708	Q>H		No	Ensembl
rs577629463	1708	Q>L		No	1000Genomes ExAC TOPMed gnomAD
rs1240366975	1709	G>C		No	TOPMed gnomAD
rs1777553859	1709	G>V		No	TOPMed
rs771226930	1710	P>A		No	ExAC TOPMed gnomAD
rs2128617202	1710	P>L		No	Ensembl
rs2128617202	1710	P>R		No	Ensembl
rs771226930	1710	P>S		No	ExAC TOPMed gnomAD
rs2128617178	1711	A>G		No	Ensembl
rs1344810205	1711	A>P		No	TOPMed gnomAD
rs1344810205	1711	A>S		No	TOPMed gnomAD
rs2128617178	1711	A>V		No	Ensembl
rs2128617161	1712	Y>*		No	Ensembl
rs2128617166	1712	Y>N		No	Ensembl
rs2128617154	1713	V>D		No	Ensembl
rs1233603510	1713	V>F		No	gnomAD
rs1233603510	1713	V>I		No	gnomAD
rs1233603510	1713	V>L		No	gnomAD
rs2128617136	1714	C>*		No	Ensembl
rs1330583699	1714	C>F		No	TOPMed gnomAD
rs2128617146	1714	C>R		No	Ensembl
rs2128617146	1714	C>S		No	Ensembl
rs1330583699	1714	C>S		No	TOPMed gnomAD
rs1330583699	1714	C>Y		No	TOPMed gnomAD
rs2128617130	1715	N>D		No	Ensembl
rs2128617124	1715	N>I		No	Ensembl
rs2128617130	1715	N>Y		No	Ensembl
rs2128617110	1716	I>M		No	Ensembl
rs778189228	1716	I>N		No	ExAC TOPMed gnomAD
rs778189228	1716	I>T		No	ExAC TOPMed gnomAD
rs749750510	1716	I>V		No	ExAC gnomAD
TCGA novel rs2128617105	1717	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs756185420	1717	T>I		No	ExAC TOPMed gnomAD
rs756185420	1717	T>K		No	ExAC TOPMed gnomAD
rs756185420	1717	T>R		No	ExAC TOPMed gnomAD
rs2128617105	1717	T>S		No	Ensembl
rs1777551250	1718	N>D		No	TOPMed
rs1777551079	1718	N>I		No	Ensembl
rs2128617078	1718	N>K		No	Ensembl
rs1777551079	1718	N>S		No	Ensembl
rs1777551079	1718	N>T		No	Ensembl
rs1777551250	1718	N>Y		No	TOPMed
rs369993254	1719	L>I		No	ESP ExAC TOPMed gnomAD
rs2128617071	1719	L>Q		No	Ensembl
rs369993254	1719	L>V		No	ESP ExAC TOPMed gnomAD
rs2128617062	1720	Q>E		No	Ensembl
rs2128617050	1720	Q>H		No	Ensembl
rs1562285267	1720	Q>L		No	Ensembl
rs1777550222	1721	P>A		No	TOPMed
rs2128617045	1721	P>L		No	Ensembl
rs2128617045	1721	P>R		No	Ensembl
rs1777550222	1721	P>S		No	TOPMed
rs1777550222	1721	P>T		No	TOPMed
rs2128617030	1722	Y>*		No	Ensembl
rs2128617035	1722	Y>H		No	Ensembl
rs1394041847	1723	T>A		No	gnomAD
rs1777549804	1723	T>I		No	TOPMed
rs1777549804	1723	T>N		No	TOPMed
rs1394041847	1723	T>P		No	gnomAD
rs1777549804 COSM1739241 COSM1739240	1723	T>S	haematopoietic_and_lymphoid_tissue [Cosmic]	No	cosmic curated TOPMed
COSM1739241 rs1394041847 COSM1739240	1723	T>S	haematopoietic_and_lymphoid_tissue [Cosmic]	No	cosmic curated gnomAD
rs2128616998	1724	S>*		No	Ensembl
rs888269782	1724	S>A		No	TOPMed gnomAD
rs2128616998	1724	S>L		No	Ensembl
rs888269782	1724	S>P		No	TOPMed gnomAD
rs888269782	1724	S>T		No	TOPMed gnomAD
rs2128616983	1725	Y>*		No	Ensembl
rs1777548452	1725	Y>C		No	TOPMed
rs1777548452	1725	Y>F		No	TOPMed
rs2128616989	1725	Y>N		No	Ensembl
rs2128616978	1726	N>D		No	Ensembl
rs2128616973	1726	N>I		No	Ensembl
rs2128616952	1727	V>A		No	Ensembl
rs2128616952	1727	V>D		No	Ensembl
rs2128616960	1727	V>F		No	Ensembl
rs2128616960	1727	V>L		No	Ensembl
rs2128616938	1728	R>*		No	Ensembl
rs2128616938	1728	R>G		No	Ensembl
rs1436828538	1728	R>K		No	gnomAD
rs2128616927	1728	R>S		No	Ensembl
rs1436828538	1728	R>T		No	gnomAD
rs2128616919	1729	V>I		No	Ensembl
COSM172878 TCGA novel rs2128616919 COSM172879	1729	V>L	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Ensembl
rs2128616909	1730	V>E		No	Ensembl
rs1777547550	1730	V>L		No	TOPMed
rs1777547550	1730	V>M		No	TOPMed
rs2128616898	1731	V>L		No	Ensembl
rs2128616898	1731	V>M		No	Ensembl
rs1777546932	1732	V>F		No	Ensembl
rs1777546932	1732	V>I		No	Ensembl
rs1777546932	1732	V>L		No	Ensembl
rs2128616873	1733	Y>*		No	Ensembl
rs765042516	1733	Y>C		No	ExAC TOPMed gnomAD
rs761535895	1734	K>*		No	ExAC gnomAD
rs2128616861	1734	K>M		No	Ensembl
rs2128616857	1734	K>N		No	Ensembl
rs2128616861	1734	K>R		No	Ensembl
rs375957426	1735	T>K		No	ESP ExAC TOPMed gnomAD
rs375957426	1735	T>M		No	ESP ExAC TOPMed gnomAD
rs2128616850	1735	T>P		No	Ensembl
rs375957426	1735	T>R		No	ESP ExAC TOPMed gnomAD
rs2128616850	1735	T>S		No	Ensembl
rs2128616835	1736	G>*		No	Ensembl
rs2128616826	1736	G>A		No	Ensembl
rs2128616826	1736	G>E		No	Ensembl
rs2128616835	1736	G>R		No	Ensembl
rs2128616826	1736	G>V		No	Ensembl
COSM1440054 COSM3157719 COSM1440055 COSM3857794 rs372371100	1737	E>*	Variant assessed as Somatic; HIGH impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ESP ExAC TOPMed gnomAD
rs372371100	1737	E>K		No	ESP ExAC TOPMed gnomAD
rs372371100	1737	E>Q		No	ESP ExAC TOPMed gnomAD
rs1777544837	1738	N>K		No	TOPMed gnomAD
rs2128616817	1738	N>Y		No	Ensembl
rs143435239	1739	S>G		No	ESP ExAC TOPMed gnomAD
rs1200612813	1739	S>I		No	TOPMed gnomAD
rs1200612813	1739	S>N		No	TOPMed gnomAD
rs143435239	1739	S>R		No	ESP ExAC TOPMed gnomAD
rs2128616790	1739	S>R		No	Ensembl
rs1200612813	1739	S>T		No	TOPMed gnomAD
TCGA novel	1740	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128616776	1740	T>I		No	Ensembl
rs2128616776	1740	T>N		No	Ensembl
rs2128616783	1740	T>P		No	Ensembl
rs2128616783	1740	T>S		No	Ensembl
rs2128616776	1740	T>S		No	Ensembl
rs1238762897	1741	S>*		No	gnomAD
rs1238762897	1741	S>L		No	gnomAD
rs774010287	1741	S>T		No	ExAC gnomAD
rs1353853010	1742	L>F		No	gnomAD
rs1353853010	1742	L>V		No	gnomAD
rs771301135	1743	P>A		No	ExAC TOPMed gnomAD
rs1242593536	1743	P>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
COSM387704 COSM387703 rs771301135	1743	P>S	lung [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs771301135	1743	P>T		No	ExAC TOPMed gnomAD
rs2128616724	1744	E>*		No	Ensembl
TCGA novel rs2128616713	1744	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128616719	1744	E>G		No	Ensembl
rs2128616724	1744	E>K		No	Ensembl
rs2128616724	1744	E>Q		No	Ensembl
rs2128616719	1744	E>V		No	Ensembl
rs749651979	1745	S>R		No	ExAC gnomAD
rs773762930	1746	F>I		No	ExAC gnomAD
rs2128616688	1746	F>L		No	Ensembl
rs2128616694	1746	F>S		No	Ensembl
rs773762930	1746	F>V		No	ExAC gnomAD
rs2128616694	1746	F>Y		No	Ensembl
rs2128616683	1747	K>M		No	Ensembl
rs2128616675	1748	T>A		No	Ensembl
rs1213350416	1748	T>I		No	TOPMed gnomAD
rs1213350416	1748	T>K		No	TOPMed gnomAD
rs1213350416	1748	T>R		No	TOPMed gnomAD
rs2128616675	1748	T>S		No	Ensembl
rs537810933	1749	K>I		No	1000Genomes ExAC TOPMed gnomAD
rs2128616653	1749	K>Q		No	Ensembl
rs537810933	1749	K>R		No	1000Genomes ExAC TOPMed gnomAD
rs537810933	1749	K>T		No	1000Genomes ExAC TOPMed gnomAD
rs768835741	1750	A>D		No	ExAC TOPMed gnomAD
rs768835741	1750	A>G		No	ExAC TOPMed gnomAD
rs1035565334	1750	A>P		No	TOPMed gnomAD
rs1035565334	1750	A>S		No	TOPMed gnomAD
rs1035565334	1750	A>T		No	TOPMed gnomAD
rs768835741	1750	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2128593641	1751	G>*		No	Ensembl
rs2128593633	1751	G>A		No	Ensembl
rs2128593633	1751	G>E		No	Ensembl
rs2128593641	1751	G>R		No	Ensembl
rs2128593633	1751	G>V		No	Ensembl
rs2128593626	1752	V>F		No	Ensembl
rs762214304	1752	V>G		No	ExAC TOPMed gnomAD
rs2128593626	1752	V>I		No	Ensembl
rs2128593626	1752	V>L		No	Ensembl
rs2128593609	1753	P>A		No	Ensembl
rs575187153	1753	P>L		No	1000Genomes ExAC gnomAD
rs575187153	1753	P>Q		No	1000Genomes ExAC gnomAD
rs575187153	1753	P>R		No	1000Genomes ExAC gnomAD
rs2128593609	1753	P>S		No	Ensembl
rs2128593609	1753	P>T		No	Ensembl
rs376099341	1754	N>K		No	ESP ExAC TOPMed gnomAD
rs2128593598	1754	N>S		No	Ensembl
rs1015244536	1754	N>Y		No	Ensembl
rs971150436	1755	K>*		No	TOPMed
rs971150436	1755	K>E		No	TOPMed
rs2128593587	1755	K>N		No	Ensembl
rs1270018924	1756	P>L		No	gnomAD
rs1270018924	1756	P>Q		No	gnomAD
rs1270018924	1756	P>R		No	gnomAD
rs2128593582	1756	P>T		No	Ensembl
rs2128593566	1757	G>A		No	Ensembl
rs1007896648	1757	G>C		No	TOPMed gnomAD
rs2128593566	1757	G>D		No	Ensembl
rs1007896648	1757	G>R		No	TOPMed gnomAD
rs1007896648	1757	G>S		No	TOPMed gnomAD
rs2128593566	1757	G>V		No	Ensembl
rs1254307589	1758	I>F		No	Ensembl
rs1254307589	1758	I>L		No	Ensembl
rs2128593553	1758	I>N		No	Ensembl
rs2128593553	1758	I>T		No	Ensembl
rs1254307589	1758	I>V		No	Ensembl
rs2128593537	1759	P>A		No	Ensembl
rs2128593532	1759	P>H		No	Ensembl
rs2128593532	1759	P>L		No	Ensembl
rs2128593532	1759	P>R		No	Ensembl
rs2128593537	1759	P>S		No	Ensembl
rs2128593537	1759	P>T		No	Ensembl
rs2128593518	1760	K>N		No	Ensembl
rs2128593523	1760	K>R		No	Ensembl
rs777368850	1761	L>*		No	ExAC gnomAD
rs777368850	1761	L>S		No	ExAC gnomAD
rs1776891255	1761	L>V		No	Ensembl
rs2128593503	1762	L>Q		No	Ensembl
rs2128593506	1762	L>V		No	Ensembl
rs755939085	1763	E>A		No	ExAC
rs2128593484	1763	E>D		No	Ensembl
rs755939085	1763	E>V		No	ExAC
rs1776890399	1764	G>A		No	gnomAD
rs1776890399	1764	G>E		No	gnomAD
rs2128593479	1764	G>R		No	Ensembl
rs1776890399	1764	G>V		No	gnomAD
rs767479948	1765	S>C		No	ExAC TOPMed gnomAD
rs2128593457	1765	S>I		No	Ensembl
rs2128593457	1765	S>N		No	Ensembl
rs1268010906	1765	S>R		No	TOPMed gnomAD
rs2128593457	1765	S>T		No	Ensembl
rs1776888919	1766	K>E		No	Ensembl
rs2128593446	1766	K>I		No	Ensembl
rs2128593444	1766	K>N		No	Ensembl
rs2128593440	1767	N>D		No	Ensembl
TCGA novel	1767	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128593429	1767	N>I		No	Ensembl
rs1776888739	1767	N>K		No	Ensembl
rs2128593429	1767	N>S		No	Ensembl
rs2128593407	1768	S>*		No	Ensembl
rs2128593413	1768	S>A		No	Ensembl
COSM3619828 COSM229018 COSM3619827 COSM229017 rs2128593407	1768	S>L	Variant assessed as Somatic; MODERATE impact. skin [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs2128593413	1768	S>T		No	Ensembl
rs1049529195	1769	I>K		No	Ensembl
rs2128593384	1769	I>M		No	Ensembl
rs1049529195	1769	I>R		No	Ensembl
rs1049529195	1769	I>T		No	Ensembl
rs1776888367	1769	I>V		No	Ensembl
rs2128593376	1770	Q>*		No	Ensembl
rs2128593376	1770	Q>E		No	Ensembl
rs2128593370	1770	Q>H		No	Ensembl
COSM228085 COSM228086 rs199563442	1771	W>*	skin [Cosmic]	No	cosmic curated gnomAD
COSM228085 COSM228086 rs1776887767	1771	W>*	skin [Cosmic]	No	cosmic curated TOPMed gnomAD
rs1776887767	1771	W>C		No	TOPMed gnomAD
rs2128593363	1771	W>G		No	Ensembl
rs199563442	1771	W>L		No	gnomAD
rs2128593363	1771	W>R		No	Ensembl
rs199563442	1771	W>S		No	gnomAD
rs1192695384	1772	E>*		No	TOPMed gnomAD
TCGA novel rs2128593329	1772	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1192695384	1772	E>K		No	TOPMed gnomAD
rs1192695384	1772	E>Q		No	TOPMed gnomAD
rs2128593324	1773	K>*		No	Ensembl
rs2128593320	1773	K>I		No	Ensembl
rs2128593317	1773	K>N		No	Ensembl
rs2128593302	1774	A>D		No	Ensembl
rs2128593302	1774	A>G		No	Ensembl
rs1776887404	1774	A>P		No	Ensembl
rs1776887404	1774	A>S		No	Ensembl
rs1776887404	1774	A>T		No	Ensembl
rs2128593302	1774	A>V		No	Ensembl
rs2128593292	1775	E>*		No	Ensembl
rs1435810299	1775	E>D		No	TOPMed gnomAD
rs2128593286	1775	E>G		No	Ensembl
rs2128593292	1775	E>K		No	Ensembl
rs2128593292	1775	E>Q		No	Ensembl
rs2128593286	1775	E>V		No	Ensembl
rs1776886464	1776	D>E		No	TOPMed
rs2128593269	1776	D>G		No	Ensembl
rs12664076 COSM150171 VAR_030652 RCV000953544 COSM150172	1776	D>H	stomach [Cosmic]	No	cosmic curated ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs12664076	1776	D>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128593269	1776	D>V		No	Ensembl
rs1776886282	1777	N>D		No	TOPMed
rs891668128	1777	N>I		No	TOPMed gnomAD
rs891668128	1777	N>S		No	TOPMed gnomAD
rs1776886282	1777	N>Y		No	TOPMed
COSM3857793 COSM3857791 rs2128593243 COSM3857792	1778	G>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128593238	1778	G>A		No	Ensembl
rs2128593238	1778	G>E		No	Ensembl
rs2128593243	1778	G>R		No	Ensembl
rs2128593238	1778	G>V		No	Ensembl
rs2128593207	1779	C>*		No	Ensembl
rs1171864743	1779	C>F		No	TOPMed gnomAD
rs762445305	1779	C>G		No	ExAC TOPMed gnomAD
rs762445305	1779	C>R		No	ExAC TOPMed gnomAD
rs762445305	1779	C>S		No	ExAC TOPMed gnomAD
rs1171864743	1779	C>S		No	TOPMed gnomAD
rs2128593207	1779	C>W		No	Ensembl
rs1171864743	1779	C>Y		No	TOPMed gnomAD
rs2128593202	1780	R>*		No	Ensembl
rs2128593202	1780	R>G		No	Ensembl
rs1410132066	1780	R>I		No	gnomAD
rs1410132066	1780	R>K		No	gnomAD
rs2128593190	1780	R>S		No	Ensembl
rs1410132066	1780	R>T		No	gnomAD
rs2128593181	1781	I>N		No	Ensembl
rs2128593181	1781	I>S		No	Ensembl
rs2128593185	1781	I>V		No	Ensembl
rs149390376	1782	T>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128593168	1782	T>I		No	Ensembl
rs149390376	1782	T>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128593168	1782	T>R		No	Ensembl
rs1295617724	1783	Y>*		No	TOPMed
rs1253149587	1783	Y>C		No	TOPMed gnomAD
rs762317256	1783	Y>D		No	ExAC TOPMed gnomAD
rs1253149587	1783	Y>F		No	TOPMed gnomAD
rs762317256	1783	Y>H		No	ExAC TOPMed gnomAD
rs762317256	1783	Y>N		No	ExAC TOPMed gnomAD
rs1195358594	1784	Y>*		No	TOPMed gnomAD
rs2128593134	1784	Y>F		No	Ensembl
rs2128593139	1784	Y>H		No	Ensembl
rs2128593139	1784	Y>N		No	Ensembl
rs2128593127	1785	I>F		No	Ensembl
rs2128593115	1785	I>M		No	Ensembl
rs2128593122	1785	I>N		No	Ensembl
rs2128593127	1785	I>V		No	Ensembl
rs2128593107	1786	L>F		No	Ensembl
rs2128593101	1786	L>H		No	Ensembl
rs2128593107	1786	L>I		No	Ensembl
rs2128593101	1786	L>P		No	Ensembl
rs2128593107	1786	L>V		No	Ensembl
rs945272881	1787	E>*		No	Ensembl
rs777247123	1787	E>D		No	ExAC gnomAD
rs2128593070	1787	E>G		No	Ensembl
rs945272881	1787	E>K		No	Ensembl
rs945272881	1787	E>Q		No	Ensembl
rs2128593070	1787	E>V		No	Ensembl
rs769355146	1788	I>L		No	ExAC TOPMed gnomAD
rs760826500	1788	I>T		No	ExAC gnomAD
rs769355146	1788	I>V		No	ExAC TOPMed gnomAD
rs2128593045	1789	R>*		No	Ensembl
rs2128593036	1789	R>I		No	Ensembl
rs2128593036	1789	R>K		No	Ensembl
rs2128582393	1789	R>S		No	Ensembl
rs2128593036	1789	R>T		No	Ensembl
rs768131640	1790	K>*		No	ExAC gnomAD
rs2128582378	1790	K>M		No	Ensembl
rs2128582375	1790	K>N		No	Ensembl
rs768131640	1790	K>Q		No	ExAC gnomAD
rs2128582371	1791	S>C		No	Ensembl
rs759533205	1791	S>I		No	ExAC gnomAD
rs759533205	1791	S>N		No	ExAC gnomAD
rs2128582360	1791	S>R		No	Ensembl
rs759533205	1791	S>T		No	ExAC gnomAD
rs2128582354	1792	T>A		No	Ensembl
rs2128582354	1792	T>S		No	Ensembl
rs2128582340	1793	S>*		No	Ensembl
rs2128582340	1793	S>L		No	Ensembl
rs2128582348	1793	S>T		No	Ensembl
rs1461762268	1794	N>D		No	TOPMed gnomAD
rs2128582324	1794	N>K		No	Ensembl
rs774351357	1794	N>T		No	ExAC gnomAD
rs1461762268	1794	N>Y		No	TOPMed gnomAD
rs1191704312	1795	N>H		No	gnomAD
rs2128582311	1795	N>K		No	Ensembl
rs1191704312	1795	N>Y		No	gnomAD
rs2128582300	1796	L>*		No	Ensembl
rs766461873	1796	L>I		No	ExAC TOPMed gnomAD
rs766461873	1796	L>V		No	ExAC TOPMed gnomAD
COSM1663951 COSM1663953 rs2128582297 COSM1663952	1797	Q>*	kidney [Cosmic]	No	cosmic curated Ensembl
rs2128582297	1797	Q>E		No	Ensembl
COSM4869092 COSM1072539 COSM1072541 rs2128582294	1797	Q>H	endometrium Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated Ensembl NCI-TCGA Cosmic
rs2128582285	1798	N>I		No	Ensembl
rs2128582283	1798	N>K		No	Ensembl
rs2128582285	1798	N>S		No	Ensembl
rs2128582291	1798	N>Y		No	Ensembl
rs2128582278	1799	Q>*		No	Ensembl
rs2128582278	1799	Q>E		No	Ensembl
rs2128582274	1799	Q>H		No	Ensembl
rs2128582278	1799	Q>K		No	Ensembl
rs763113386	1800	N>D		No	ExAC gnomAD
rs2128582267	1800	N>I		No	Ensembl
COSM3857790 COSM3857789	1800	N>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128582255	1801	L>*		No	Ensembl
rs2128582260	1801	L>I		No	Ensembl
rs2128582249	1802	R>G		No	Ensembl
rs2128582242	1802	R>S		No	Ensembl
rs1385575949	1802	R>T		No	TOPMed gnomAD
rs2128582249	1802	R>W		No	Ensembl
rs2128582229	1803	W>*		No	Ensembl
rs2128582219	1803	W>*		No	Ensembl
rs2128582219	1803	W>C		No	Ensembl
rs2128582229	1803	W>L		No	Ensembl
rs2128582238	1803	W>R		No	Ensembl
rs2128582229	1803	W>S		No	Ensembl
rs2128582212	1804	K>M		No	Ensembl
COSM4863626 COSM1072538 rs2128582209 COSM1072536	1804	K>N	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated Ensembl NCI-TCGA Cosmic
rs2128582192	1805	M>I		No	Ensembl
rs2128582200	1805	M>K		No	Ensembl
rs2128582208	1805	M>L		No	Ensembl
rs2128582200	1805	M>T		No	Ensembl
rs538540508	1806	T>A		No	1000Genomes ExAC TOPMed gnomAD
rs768305668	1806	T>I		No	ExAC gnomAD
rs768305668	1806	T>R		No	ExAC gnomAD
rs538540508	1806	T>S		No	1000Genomes ExAC TOPMed gnomAD
rs376765085	1807	F>I		No	ESP ExAC gnomAD
rs376765085	1807	F>L		No	ESP ExAC gnomAD
rs2128582171	1807	F>L		No	Ensembl
rs2128582176	1807	F>Y		No	Ensembl
rs2128582169	1808	N>I		No	Ensembl
rs1337334412	1808	N>K		No	gnomAD
rs2128582169	1808	N>S		No	Ensembl
rs2128582160	1809	G>*		No	Ensembl
rs1776645074	1809	G>A		No	TOPMed
rs1776645074	1809	G>E		No	TOPMed
rs2128582160	1809	G>R		No	Ensembl
rs1776645074	1809	G>V		No	TOPMed
rs1256569613	1810	S>C		No	TOPMed gnomAD
COSM139667 COSM3619826 rs1256569613	1810	S>F	Variant assessed as Somatic; MODERATE impact. skin [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1776644896	1810	S>P		No	TOPMed
rs1776644896	1810	S>T		No	TOPMed
rs1256569613	1810	S>Y		No	TOPMed gnomAD
rs775276256	1811	C>*		No	ExAC gnomAD
rs1776644440	1811	C>F		No	TOPMed
rs1776644609	1811	C>R		No	gnomAD
rs1776644440	1811	C>S		No	TOPMed
rs1776644609	1811	C>S		No	gnomAD
rs775276256	1811	C>W		No	ExAC gnomAD
rs981579627	1812	S>C		No	TOPMed gnomAD
rs981579627	1812	S>G		No	TOPMed gnomAD
rs2128582105	1812	S>N		No	Ensembl
rs1776643916	1812	S>R		No	Ensembl
rs981579627	1812	S>R		No	TOPMed gnomAD
rs2128582105	1812	S>T		No	Ensembl
rs2128582097	1813	S>C		No	Ensembl
rs2128582097	1813	S>G		No	Ensembl
rs1562274440	1813	S>R		No	Ensembl
rs2128582094	1813	S>T		No	Ensembl
rs2128582077	1814	V>A		No	Ensembl
rs2128582077	1814	V>D		No	Ensembl
rs2128582080	1814	V>F		No	Ensembl
rs2128582080	1814	V>I		No	Ensembl
rs2128582080	1814	V>L		No	Ensembl
rs2128582056	1815	C>*		No	Ensembl
rs2128582066	1815	C>R		No	Ensembl
rs374557840	1815	C>S		No	ESP ExAC TOPMed gnomAD
rs2128582066	1815	C>S		No	Ensembl
rs2128582056	1815	C>W		No	Ensembl
rs139756894	1816	T>I		No	ESP ExAC TOPMed
rs139756894	1816	T>K		No	ESP ExAC TOPMed
rs745796221	1816	T>P		No	ExAC TOPMed gnomAD
rs139756894	1816	T>R		No	ESP ExAC TOPMed
rs745796221	1816	T>S		No	ExAC TOPMed gnomAD
COSM4875583 COSM1697822 COSM1697821 COSM1072533 rs1441561770 COSM1072535	1817	W>*	Variant assessed as Somatic; HIGH impact. skin endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA gnomAD
COSM1697822 rs1325118655 COSM1697821 COSM1072533 COSM1072535	1817	W>*	Variant assessed as Somatic; HIGH impact. endometrium skin [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA gnomAD
rs1441561770	1817	W>C		No	gnomAD
rs1364957975	1817	W>R		No	gnomAD
rs1325118655	1817	W>S		No	gnomAD
rs2128582022	1818	K>M		No	Ensembl
rs2128582020	1818	K>N		No	Ensembl
rs1444793816	1819	S>C		No	TOPMed gnomAD
rs1444793816	1819	S>F		No	TOPMed gnomAD
rs2128582013	1819	S>P		No	Ensembl
rs2128582013	1819	S>T		No	Ensembl
rs1444793816	1819	S>Y		No	TOPMed gnomAD
rs2128581993	1820	K>I		No	Ensembl
rs2128581993	1820	K>R		No	Ensembl
rs571578275	1821	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes NCI-TCGA gnomAD
rs916060109	1821	N>I		No	Ensembl
rs916060109	1821	N>S		No	Ensembl
rs916060109	1821	N>T		No	Ensembl
COSM1440053 COSM5140753	1821	N>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel rs2128581956	1822	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128581950	1822	L>P		No	Ensembl
rs2128581950	1822	L>Q		No	Ensembl
rs2128581956	1822	L>V		No	Ensembl
rs2128581938	1823	K>*		No	Ensembl
rs756847163	1823	K>N		No	ExAC gnomAD
rs1776641070	1824	G>A		No	Ensembl
rs1776641070	1824	G>E		No	Ensembl
rs2128581929	1824	G>R		No	Ensembl
rs1776641070	1824	G>V		No	Ensembl
rs2128581903	1825	I>K		No	Ensembl
rs199815114	1825	I>M		No	1000Genomes ExAC TOPMed gnomAD
rs991660668	1825	I>V		No	TOPMed gnomAD
COSM272180 rs2128581888 COSM272179	1826	F>L	large_intestine Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated Ensembl NCI-TCGA Cosmic
rs1172893180	1826	F>S		No	gnomAD
rs1172893180	1826	F>Y		No	gnomAD
rs867760368	1827	Q>*		No	Ensembl
rs867760368	1827	Q>E		No	Ensembl
rs1562274313	1827	Q>H		No	Ensembl
rs867760368	1827	Q>K		No	Ensembl
rs1202977274	1827	Q>L		No	gnomAD
rs1202977274	1827	Q>R		No	gnomAD
rs2128581860	1828	F>I		No	Ensembl
rs2128581848	1828	F>L		No	Ensembl
rs2128581860	1828	F>L		No	Ensembl
rs2128581860	1828	F>V		No	Ensembl
rs2128581856	1828	F>Y		No	Ensembl
rs2128581842	1829	R>*		No	Ensembl
rs2128581842	1829	R>G		No	Ensembl
rs2128581835	1829	R>I		No	Ensembl
TCGA novel	1829	R>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128581835	1829	R>K		No	Ensembl
TCGA novel rs2128581835	1829	R>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128581817	1830	V>E		No	Ensembl
rs2128581817	1830	V>G		No	Ensembl
rs1263855825	1830	V>I		No	TOPMed
rs1263855825	1830	V>L		No	TOPMed
rs1266780413	1831	V>A		No	gnomAD
rs1266780413	1831	V>E		No	gnomAD
rs777604573	1831	V>I		No	ExAC TOPMed gnomAD
rs777604573	1831	V>L		No	ExAC TOPMed gnomAD
rs2128581783	1832	A>D		No	Ensembl
rs2128581783	1832	A>G		No	Ensembl
rs2128581791	1832	A>P		No	Ensembl
rs2128581791	1832	A>S		No	Ensembl
rs2128581791	1832	A>T		No	Ensembl
rs2128581783	1832	A>V		No	Ensembl
rs1017229529	1833	A>E		No	gnomAD
rs1017229529	1833	A>G		No	gnomAD
rs2128581772	1833	A>P		No	Ensembl
rs2128581772	1833	A>T		No	Ensembl
rs1017229529	1833	A>V		No	gnomAD
rs2128581765	1834	N>K		No	Ensembl
rs1562274270	1834	N>S		No	Ensembl
rs2128581759	1835	N>I		No	Ensembl
rs2128581758	1835	N>K		No	Ensembl
rs2128581751	1836	L>Q		No	Ensembl
rs2128581755	1836	L>V		No	Ensembl
rs2128581733	1837	G>A		No	Ensembl
rs2128581733	1837	G>E		No	Ensembl
rs2128581744	1837	G>R		No	Ensembl
rs2128581733	1837	G>V		No	Ensembl
TCGA novel rs2128581744	1837	G>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128581719	1838	F>I		No	Ensembl
rs2128581719	1838	F>L		No	Ensembl
rs753176603	1838	F>L		No	ExAC gnomAD
rs2128581719	1838	F>V		No	Ensembl
rs2128581713	1838	F>Y		No	Ensembl
rs2128581702	1839	G>A		No	Ensembl
rs147253951	1839	G>C		No	ESP ExAC gnomAD
rs2128581702	1839	G>D		No	Ensembl
rs2128581702	1839	G>V		No	Ensembl
COSM1072530 rs2128581694 COSM1072532 COSM4865525	1840	E>*	Variant assessed as Somatic; HIGH impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic Ensembl
rs2128581694	1840	E>K		No	Ensembl
rs377348361	1841	Y>*		No	ESP ExAC TOPMed gnomAD
rs755458230	1841	Y>C		No	ExAC gnomAD
rs2128581691	1841	Y>D		No	Ensembl
rs755458230	1841	Y>F		No	ExAC gnomAD
rs2128581691	1841	Y>N		No	Ensembl
rs1776638145	1842	S>C		No	TOPMed
rs1776638145	1842	S>G		No	TOPMed
rs1229224998	1842	S>N		No	gnomAD
rs766406712	1842	S>R		No	ExAC gnomAD
rs1229224998	1842	S>T		No	gnomAD
rs2128581669	1843	G>*		No	Ensembl
rs2128581663	1843	G>A		No	Ensembl
COSM4394786 COSM4394787 rs2128581669	1843	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128581660	1844	I>L		No	Ensembl
rs2128581647	1844	I>M		No	Ensembl
rs2128581654	1844	I>N		No	Ensembl
rs2128581654	1844	I>S		No	Ensembl
rs2128581660	1844	I>V		No	Ensembl
rs1163897006	1845	S>C		No	TOPMed gnomAD
rs1163897006	1845	S>G		No	TOPMed gnomAD
rs2128581636	1845	S>I		No	Ensembl
rs2128581636	1845	S>N		No	Ensembl
rs2128581633	1845	S>R		No	Ensembl
rs1163897006	1845	S>R		No	TOPMed gnomAD
rs2128581636	1845	S>T		No	Ensembl
rs763061412	1846	E>G		No	ExAC gnomAD
rs2128581629	1846	E>K		No	Ensembl
rs2128581629	1846	E>Q		No	Ensembl
rs2128581615	1847	N>K		No	Ensembl
rs2128581623	1847	N>Y		No	Ensembl
rs765553432	1848	I>F		No	ExAC gnomAD
rs765553432	1848	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2128581605	1848	I>N		No	Ensembl
rs2128581605	1848	I>T		No	Ensembl
rs765553432	1848	I>V		No	ExAC gnomAD
rs2128581593	1849	I>K		No	Ensembl
rs1329285758	1849	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs143846827	1849	I>V		No	ESP ExAC TOPMed gnomAD
rs1399029201	1850	L>*		No	TOPMed gnomAD
rs1390601271	1850	L>F		No	gnomAD
rs2128581574	1851	V>D		No	Ensembl
rs2128581577	1851	V>F		No	Ensembl
rs2128581577	1851	V>I		No	Ensembl
rs2128581577	1851	V>L		No	Ensembl
rs1776636276	1852	G>*		No	Ensembl
rs2128581568	1852	G>A		No	Ensembl
rs2128581568	1852	G>E		No	Ensembl
rs1776636276	1852	G>R		No	Ensembl
rs2128581568	1852	G>V		No	Ensembl
rs138265888	1853	D>A		No	ESP ExAC TOPMed gnomAD
rs1776495123	1853	D>E		No	Ensembl
rs138265888	1853	D>G		No	ESP ExAC TOPMed gnomAD
rs1776636107	1853	D>H		No	Ensembl
rs1776636107	1853	D>N		No	Ensembl
rs1776636107	1853	D>Y		No	Ensembl
TCGA novel rs192321490	1854	D>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC TOPMed gnomAD NCI-TCGA
rs1158436866	1854	D>G		No	gnomAD
rs1776494978	1854	D>H		No	TOPMed gnomAD
rs1776494978	1854	D>N		No	TOPMed gnomAD
rs1158436866	1854	D>V		No	gnomAD
rs1776494978	1854	D>Y		No	TOPMed gnomAD
TCGA novel rs2128575146	1855	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128575152	1855	F>S		No	Ensembl
rs1776494361	1855	F>V		No	gnomAD
rs2128575133	1856	W>*		No	Ensembl
rs2128575133	1856	W>C		No	Ensembl
rs2128575139	1856	W>G		No	Ensembl
rs2128575139	1856	W>R		No	Ensembl
rs1776493978	1857	I>K		No	TOPMed
rs2128575129	1857	I>M		No	Ensembl
rs1776493791	1858	P>A		No	Ensembl
rs1185894476	1858	P>L		No	gnomAD
rs1185894476	1858	P>R		No	gnomAD
rs1776493791	1858	P>S		No	Ensembl
COSM4946245 COSM1568110 COSM1568111 rs1776493791	1858	P>T	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic Ensembl
rs2128575102	1859	E>D		No	Ensembl
rs1366078744	1859	E>G		No	gnomAD
rs2128575114	1859	E>K		No	Ensembl
rs2128575114	1859	E>Q		No	Ensembl
rs1366078744	1859	E>V		No	gnomAD
rs1256328685	1860	T>I		No	gnomAD
rs1423646118	1860	T>P		No	gnomAD
rs1256328685	1860	T>R		No	gnomAD
rs1423646118	1860	T>S		No	gnomAD
rs774405508	1861	S>C		No	ExAC gnomAD
rs774405508	1861	S>G		No	ExAC gnomAD
rs2128575084	1861	S>I		No	Ensembl
rs2128575084	1861	S>N		No	Ensembl
rs2128575078	1861	S>R		No	Ensembl
rs2128575084	1861	S>T		No	Ensembl
rs2128575076	1862	F>I		No	Ensembl
rs1299626570	1862	F>L		No	TOPMed
rs2128575067	1862	F>S		No	Ensembl
rs2128575067	1862	F>Y		No	Ensembl
rs2128575049	1863	I>K		No	Ensembl
rs771062502	1863	I>L		No	ExAC TOPMed gnomAD
rs2128575045	1863	I>M		No	Ensembl
rs2128575049	1863	I>T		No	Ensembl
rs771062502	1863	I>V		No	ExAC TOPMed gnomAD
rs762992946	1864	L>F		No	ExAC gnomAD
rs2128575030	1864	L>H		No	1000Genomes
rs762992946	1864	L>I		No	ExAC gnomAD
TCGA novel rs2128575030	1864	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA 1000Genomes
rs762992946	1864	L>V		No	ExAC gnomAD
rs772723253	1865	T>A		No	ExAC gnomAD
rs373534757 COSM1568113 COSM4946293 COSM1568112	1865	T>I	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ESP ExAC TOPMed gnomAD
rs373534757	1865	T>S		No	ESP ExAC TOPMed gnomAD
rs2128575006	1866	I>F		No	Ensembl
rs1281863309	1867	I>T		No	TOPMed gnomAD
rs1357854573	1868	V>A		No	TOPMed
rs1357854573	1868	V>D		No	TOPMed
rs2128574993	1868	V>F		No	Ensembl
rs2128574993	1868	V>I		No	Ensembl
rs2128574993	1868	V>L		No	Ensembl
rs747799388	1869	G>A		No	ExAC gnomAD
rs747799388	1869	G>E		No	ExAC gnomAD
rs1246573918	1869	G>R		No	TOPMed
rs747799388	1869	G>V		No	ExAC gnomAD
rs2128574958	1870	I>K		No	Ensembl
rs2128574965	1870	I>L		No	Ensembl
rs2128574953	1870	I>M		No	Ensembl
rs2128574958	1870	I>R		No	Ensembl
rs2128574958	1870	I>T		No	Ensembl
rs2128574947	1871	F>L		No	Ensembl
rs1354660665	1871	F>L		No	gnomAD
rs1354660665	1871	F>V		No	gnomAD
rs2128574936	1872	L>P		No	Ensembl
rs2128574936	1872	L>Q		No	Ensembl
rs2128574941	1872	L>V		No	Ensembl
rs1416865807	1873	V>F		No	gnomAD
rs1416865807	1873	V>I		No	gnomAD
rs1416865807	1873	V>L		No	gnomAD
rs2128574910	1874	V>A		No	Ensembl
rs2128574910	1874	V>D		No	Ensembl
rs2128574910	1874	V>G		No	Ensembl
rs2128574918	1874	V>I		No	Ensembl
rs2128574918	1874	V>L		No	Ensembl
rs1338433823	1875	T>I		No	gnomAD
rs1338433823	1875	T>R		No	gnomAD
rs1317756919	1876	I>F		No	gnomAD
rs1317756919	1876	I>L		No	gnomAD
rs768985780	1876	I>M		No	ExAC gnomAD
rs2128574885	1876	I>N		No	Ensembl
rs1317756919	1876	I>V		No	gnomAD
rs147114498	1877	P>A		No	ESP TOPMed gnomAD
rs2128574874	1877	P>L		No	Ensembl
rs2128574874	1877	P>Q		No	Ensembl
rs2128574874	1877	P>R		No	Ensembl
rs147114498	1877	P>S		No	ESP TOPMed gnomAD
rs147114498	1877	P>T		No	ESP TOPMed gnomAD
rs2128574861	1878	L>P		No	Ensembl
rs2128574861	1878	L>Q		No	Ensembl
rs2128574864	1878	L>V		No	Ensembl
rs1365189835	1879	T>I		No	gnomAD
rs1365189835	1879	T>N		No	gnomAD
rs1365189835	1879	T>S		No	gnomAD
rs2128574852	1879	T>S		No	Ensembl
rs2128574837	1880	F>I		No	Ensembl
rs2128574837	1880	F>L		No	Ensembl
rs2128574830	1880	F>L		No	Ensembl
rs2128574836	1880	F>S		No	Ensembl
rs2128574836	1880	F>Y		No	Ensembl
rs2128563736	1881	V>D		No	Ensembl
rs2128574826	1881	V>F		No	Ensembl
rs2128574826	1881	V>I		No	Ensembl
rs2128574826	1881	V>L		No	Ensembl
rs2128563722	1882	W>*		No	Ensembl
rs779681565	1882	W>*		No	Ensembl
rs779681565	1882	W>C		No	Ensembl
rs2128563722	1882	W>L		No	Ensembl
rs2128563728	1882	W>R		No	Ensembl
rs2128563722	1882	W>S		No	Ensembl
TCGA novel	1883	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs368278112	1883	H>Q		No	ESP ExAC gnomAD
rs768363603	1883	H>R		No	ExAC TOPMed gnomAD
rs867259158	1884	R>*		No	Ensembl
rs867259158	1884	R>G		No	Ensembl
rs2128563706 COSM360222 COSM360221	1884	R>I	lung [Cosmic]	No	cosmic curated Ensembl
rs2128563706 COSM1697819 COSM1697820	1884	R>K	skin [Cosmic]	No	cosmic curated Ensembl
rs1776281708	1884	R>S		No	gnomAD
rs2128563706	1884	R>T		No	Ensembl
rs2128563694	1885	R>*		No	Ensembl
rs2128563691	1885	R>I		No	Ensembl
rs2128563691	1885	R>K		No	Ensembl
rs2128563691	1885	R>T		No	Ensembl
rs2128563680	1886	L>*		No	Ensembl
rs531342025	1886	L>F		No	Ensembl
rs2128563685	1886	L>I		No	Ensembl
rs2128563669	1887	K>M		No	Ensembl
rs2128563666	1887	K>N		No	Ensembl
COSM1072527 COSM4870129 rs1243356301 COSM1072529	1887	K>Q	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA gnomAD
rs2128563660	1888	N>D		No	Ensembl
rs2128563655	1888	N>K		No	Ensembl
rs932526376	1888	N>S		No	Ensembl
rs2128563660	1888	N>Y		No	Ensembl
rs1191591961	1889	Q>*		No	gnomAD
rs1191591961	1889	Q>E		No	gnomAD
rs2128563638	1889	Q>H		No	Ensembl
rs1191591961	1889	Q>K		No	gnomAD
rs1015032434	1889	Q>L		No	Ensembl
COSM1072524 rs1015032434 COSM1072526 COSM4876074	1889	Q>P	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic Ensembl
rs1015032434	1889	Q>R		No	Ensembl
rs144529412	1890	K>*		No	1000Genomes ESP ExAC TOPMed gnomAD
RCV000905994 rs144529412	1890	K>E		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs772446253	1890	K>I		No	ExAC gnomAD
rs2128563625	1890	K>N		No	Ensembl
COSM1720289 rs772446253 COSM1720288	1890	K>R	NS [Cosmic]	No	cosmic curated ExAC gnomAD
rs1484121618	1891	S>C		No	TOPMed gnomAD
rs1484121618	1891	S>G		No	TOPMed gnomAD
rs1776279723	1891	S>N		No	Ensembl
rs1215308837	1891	S>R		No	TOPMed gnomAD
rs2128563611	1892	A>D		No	Ensembl
rs2128563611	1892	A>G		No	Ensembl
rs2128563619	1892	A>P		No	Ensembl
rs2128563619	1892	A>S		No	Ensembl
rs2128563619	1892	A>T		No	Ensembl
rs2128563611	1892	A>V		No	Ensembl
rs1776279132	1893	K>M		No	TOPMed
rs1776278991	1893	K>N		No	gnomAD
rs1776279132	1893	K>R		No	TOPMed
rs2128563596	1894	E>*		No	Ensembl
rs1562269193 COSM3857786 COSM3857785	1894	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA Cosmic
rs2128563596 TCGA novel	1894	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128563596	1894	E>Q		No	Ensembl
rs2128563579	1895	G>A		No	Ensembl
rs2128563579	1895	G>E		No	Ensembl
rs1582613950	1895	G>R		No	TOPMed
rs1582613950	1895	G>W		No	TOPMed
rs1215395631	1896	V>A		No	gnomAD
rs2128563569	1896	V>M		No	Ensembl
rs2128563554	1897	T>I		No	Ensembl
rs2128563554	1897	T>R		No	Ensembl
rs1273188915	1898	V>E		No	gnomAD
rs2128563543 TCGA novel	1898	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs2128563543	1898	V>M		No	Ensembl
rs2128563534	1899	L>F		No	Ensembl
rs2128563529	1899	L>H		No	Ensembl
rs2128563529	1899	L>P		No	Ensembl
rs2128563534	1899	L>V		No	Ensembl
rs2128563523	1900	I>K		No	Ensembl
rs757333668	1900	I>M		No	ExAC gnomAD
rs2128563523	1900	I>R		No	Ensembl
rs2128563518	1901	N>I		No	Ensembl
rs9489124	1902	E>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1354382723	1902	E>D		No	gnomAD
RCV000949726 VAR_030653 rs9489124	1902	E>K		No	ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs9489124	1902	E>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128563505	1902	E>V		No	Ensembl
rs2128563494	1903	D>A		No	Ensembl
rs2128563490	1903	D>E		No	Ensembl
rs2128563494	1903	D>G		No	Ensembl
rs2128563501	1903	D>H		No	Ensembl
rs2128563501	1903	D>N		No	Ensembl
rs2128563494	1903	D>V		No	Ensembl
TCGA novel	1903	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs752993568	1904	K>*		No	ExAC gnomAD
rs752993568	1904	K>E		No	ExAC gnomAD
rs2128563483	1904	K>I		No	Ensembl
rs2128563480	1904	K>N		No	Ensembl
rs2128563483	1904	K>R		No	Ensembl
rs1776276302	1905	E>D		No	Ensembl
rs1776276465	1905	E>K		No	Ensembl
COSM4849994 rs1776276465 COSM4849995	1905	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128563471	1905	E>V		No	Ensembl
rs2128563462	1906	L>*		No	Ensembl
rs2128563456	1906	L>F		No	Ensembl
rs2128563466	1906	L>M		No	Ensembl
rs2128563462	1906	L>S		No	Ensembl
rs2128563466	1906	L>V		No	Ensembl
rs2128563462	1906	L>W		No	Ensembl
rs2128563445	1907	A>D		No	Ensembl
rs2128563445	1907	A>G		No	Ensembl
rs1193401267	1907	A>P		No	TOPMed gnomAD
TCGA novel rs1193401267	1907	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1193401267	1907	A>T		No	TOPMed gnomAD
rs2128563445	1907	A>V		No	Ensembl
rs900769132	1908	E>*		No	Ensembl
rs1171222730	1908	E>D		No	TOPMed gnomAD
rs1420974283	1908	E>G		No	gnomAD
rs900769132	1908	E>K		No	Ensembl
rs900769132	1908	E>Q		No	Ensembl
rs1420974283	1908	E>V		No	gnomAD
rs2128563414	1909	L>P		No	Ensembl
rs2128563414	1909	L>Q		No	Ensembl
rs2128563417	1909	L>V		No	Ensembl
COSM1487168 rs750354810 COSM1487167 COSM4815175	1910	R>*	Variant assessed as Somatic; HIGH impact. breast [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs750354810	1910	R>G		No	ExAC TOPMed gnomAD
rs765146445	1910	R>P		No	ExAC gnomAD
rs765146445	1910	R>Q		No	ExAC gnomAD
rs1195494731	1911	G>A		No	gnomAD
rs2128563388	1911	G>C		No	Ensembl
rs1195494731	1911	G>D		No	gnomAD
rs2128563388	1911	G>R		No	Ensembl
rs2128563388	1911	G>S		No	Ensembl
rs1195494731	1911	G>V		No	gnomAD
rs761381751	1912	L>P		No	ExAC TOPMed gnomAD
rs761381751	1912	L>Q		No	ExAC TOPMed gnomAD
rs2128563376	1912	L>V		No	Ensembl
rs1232097218	1913	A>G		No	gnomAD
rs1225424758	1913	A>P		No	TOPMed gnomAD
rs1225424758	1913	A>S		No	TOPMed gnomAD
rs1225424758	1913	A>T		No	TOPMed gnomAD
rs1206955918	1914	A>D		No	Ensembl
rs1206955918	1914	A>G		No	Ensembl
rs2128563348	1914	A>P		No	Ensembl
rs2128563348	1914	A>T		No	Ensembl
rs1206955918	1914	A>V		No	Ensembl
rs759091073	1915	G>*		No	ExAC TOPMed gnomAD
rs759091073	1915	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1776272603	1915	G>V		No	TOPMed
rs1582613564	1916	V>A		No	Ensembl
rs1582613564	1916	V>E		No	Ensembl
rs1582613564	1916	V>G		No	Ensembl
rs201309045	1916	V>I		No	1000Genomes
rs201309045	1916	V>L		No	1000Genomes
rs775152205	1917	G>A		No	ExAC gnomAD
rs2128563292	1917	G>C		No	Ensembl
rs775152205	1917	G>D		No	ExAC gnomAD
rs2128563292	1917	G>R		No	Ensembl
rs2128563292	1917	G>S		No	Ensembl
rs775152205	1917	G>V		No	ExAC gnomAD
rs1438069741	1918	L>P		No	TOPMed gnomAD
rs1438069741	1918	L>Q		No	TOPMed gnomAD
rs201816432	1918	L>V		No	1000Genomes ExAC TOPMed gnomAD
rs2128563262	1919	A>P		No	Ensembl
rs2128563262	1919	A>S		No	Ensembl
rs2128563262	1919	A>T		No	Ensembl
rs1348779301	1919	A>V		No	TOPMed gnomAD
rs2128563248	1920	N>H		No	Ensembl
rs2128563241	1920	N>I		No	Ensembl
rs2128563241	1920	N>S		No	Ensembl
rs2128563248	1920	N>Y		No	Ensembl
rs2128563225	1921	A>G		No	Ensembl
rs2128563230	1921	A>P		No	Ensembl
rs2128563230	1921	A>S		No	Ensembl
rs2128563230	1921	A>T		No	Ensembl
rs2128563225	1921	A>V		No	Ensembl
rs2128563211	1922	C>F		No	Ensembl
rs2128563211	1922	C>S		No	Ensembl
rs2128563217	1922	C>S		No	Ensembl
rs1361114278	1922	C>W		No	TOPMed
rs2128563211	1922	C>Y		No	Ensembl
rs2128563199	1923	Y>*		No	Ensembl
rs149066655	1923	Y>C		No	ESP TOPMed gnomAD
rs149066655	1923	Y>F		No	ESP TOPMed gnomAD
rs2128563206	1923	Y>H		No	Ensembl
rs2128563206	1923	Y>N		No	Ensembl
rs2128563192	1924	A>G		No	Ensembl
rs952758019	1924	A>S		No	TOPMed gnomAD
TCGA novel rs2128563192	1924	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128563185	1925	I>K		No	Ensembl
rs2128563180	1925	I>M		No	Ensembl
rs2128563185	1925	I>R		No	Ensembl
rs144955662	1926	H>D		No	ESP ExAC TOPMed gnomAD
rs771279875	1926	H>L		No	ExAC TOPMed gnomAD
rs144955662	1926	H>N		No	ESP ExAC TOPMed gnomAD
rs2128559202	1926	H>Q		No	Ensembl
rs771279875	1926	H>R		No	ExAC TOPMed gnomAD
rs144955662	1926	H>Y		No	ESP ExAC TOPMed gnomAD
rs1776181305	1927	T>I		No	TOPMed gnomAD
rs2128559200	1927	T>P		No	Ensembl
rs1776181305	1927	T>S		No	TOPMed gnomAD
rs2128559200	1927	T>S		No	Ensembl
COSM202090 COSM202089 rs2128559187	1928	L>F	large_intestine [Cosmic]	No	cosmic curated Ensembl
rs2128559182	1928	L>H		No	Ensembl
rs2128559187	1928	L>I		No	Ensembl
rs2128559187	1928	L>V		No	Ensembl
rs1420331738	1929	P>A		No	gnomAD
rs2128559170 TCGA novel	1929	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128559170	1929	P>Q		No	Ensembl
rs2128559170	1929	P>R		No	Ensembl
rs1420331738	1929	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1420331738	1929	P>T		No	gnomAD
COSM4454781 COSM4454782 rs1467543506	1930	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed gnomAD
rs763424996	1930	T>I		No	ExAC gnomAD
rs763424996	1930	T>N		No	ExAC gnomAD
rs1467543506	1930	T>P		No	TOPMed gnomAD
rs763424996	1930	T>S		No	ExAC gnomAD
rs1467543506	1930	T>S		No	TOPMed gnomAD
rs2128559146	1931	Q>*		No	Ensembl
rs1776180125	1931	Q>H		No	Ensembl
rs762415150	1932	E>D		No	ExAC gnomAD
rs773843792	1932	E>K		No	ExAC gnomAD
rs773843792	1932	E>Q		No	ExAC gnomAD
rs776794430	1933	E>D		No	ExAC gnomAD
rs2128559131	1933	E>G		No	Ensembl
COSM3157686 COSM3157687	1933	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128559131	1933	E>V		No	Ensembl
rs2128559120	1934	I>F		No	Ensembl
rs145318764	1934	I>M		No	ESP TOPMed gnomAD
rs1562267809	1934	I>N		No	Ensembl
rs1562267809	1934	I>S		No	Ensembl
rs1562267809	1934	I>T		No	Ensembl
rs2128559111	1935	E>D		No	Ensembl
rs1266834243	1936	N>I		No	TOPMed gnomAD
rs1266834243	1936	N>S		No	TOPMed gnomAD
rs1266834243	1936	N>T		No	TOPMed gnomAD
rs2128559108	1936	N>Y		No	Ensembl
rs2128559097	1937	L>F		No	Ensembl
rs2128559091	1937	L>H		No	Ensembl
rs2128559091	1937	L>P		No	Ensembl
rs2128559097	1937	L>V		No	Ensembl
rs2128559085	1938	P>A		No	Ensembl
rs2128559082	1938	P>H		No	Ensembl
rs2128559082	1938	P>L		No	Ensembl
rs2128559082	1938	P>R		No	Ensembl
rs2128559085	1938	P>S		No	Ensembl
rs747157273	1939	A>D		No	ExAC TOPMed gnomAD
rs747157273	1939	A>G		No	ExAC TOPMed gnomAD
rs2128559075	1939	A>P		No	Ensembl
rs2128559075	1939	A>S		No	Ensembl
rs2128559075	1939	A>T		No	Ensembl
rs747157273	1939	A>V		No	ExAC TOPMed gnomAD
rs2128559064	1940	F>I		No	Ensembl
rs2128559064	1940	F>L		No	Ensembl
rs2128559060	1941	P>A		No	Ensembl
rs1306349293	1941	P>L		No	gnomAD
rs2128559060	1941	P>S		No	Ensembl
rs2128559060	1941	P>T		No	Ensembl
rs370269692	1942	R>G		No	ESP ExAC TOPMed gnomAD
COSM739505 COSM739504 COSM1647879 rs1562267726	1942	R>L	lung [Cosmic]	No	cosmic curated Ensembl
rs1562267726	1942	R>P		No	Ensembl
rs1562267726	1942	R>Q		No	Ensembl
rs370269692	1942	R>W		No	ESP ExAC TOPMed gnomAD
rs2128559025	1943	E>D		No	Ensembl
COSM3619825 rs866970127 COSM3619824	1943	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
rs376207197	1944	K>E		No	ESP ExAC gnomAD
rs2128559020	1944	K>I		No	Ensembl
rs2128559016	1944	K>N		No	Ensembl
COSM1440049 COSM4783524 COSM1440048 rs2128559013	1945	L>P	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic Ensembl
rs2128559013	1945	L>Q		No	Ensembl
rs2128559008	1946	T>A		No	Ensembl
rs2128559008	1946	T>P		No	Ensembl
rs2128559008	1946	T>S		No	Ensembl
rs2128559002	1946	T>S		No	Ensembl
rs2128558996	1947	L>V		No	Ensembl
rs777678761	1948	R>C		No	ExAC TOPMed gnomAD
rs777678761	1948	R>G		No	ExAC TOPMed gnomAD
rs140237260	1948	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs140237260	1948	R>L		No	ESP ExAC TOPMed gnomAD
rs777678761	1948	R>S		No	ExAC TOPMed gnomAD
rs2128558980 COSM5922541 COSM5922542	1949	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128558972	1949	L>H		No	Ensembl
rs2128558980	1949	L>V		No	Ensembl
rs1776175234	1950	L>F		No	Ensembl
rs1776175430	1950	L>M		No	Ensembl
rs2128558962	1950	L>S		No	Ensembl
COSM1072521 COSM1072523 rs2128558952	1951	L>M	endometrium [Cosmic]	No	cosmic curated Ensembl
rs1776175069	1951	L>P		No	TOPMed
rs1776175069	1951	L>Q		No	TOPMed
rs1776175069	1951	L>R		No	TOPMed
rs2128558952	1951	L>V		No	Ensembl
rs2128558939	1952	G>E		No	Ensembl
rs2128558941	1952	G>R		No	Ensembl
rs1776174545	1953	S>C		No	Ensembl
rs1776174545	1953	S>G		No	Ensembl
rs2128558929	1953	S>I		No	Ensembl
rs2128558929	1953	S>N		No	Ensembl
rs2128558923	1953	S>R		No	Ensembl
rs2128558929	1953	S>T		No	Ensembl
rs752657920	1954	G>E		No	ExAC gnomAD
rs1776174228	1955	A>D		No	TOPMed
rs1776174228	1955	A>G		No	TOPMed
rs780532965	1955	A>P		No	ExAC gnomAD
rs780532965	1955	A>S		No	ExAC gnomAD
rs780532965	1955	A>T		No	ExAC gnomAD
rs1776174228	1955	A>V		No	TOPMed
rs2128558883	1956	F>I		No	Ensembl
rs1207412705	1956	F>L		No	TOPMed gnomAD
rs2128558878	1956	F>Y		No	Ensembl
rs2128558870	1957	G>*		No	Ensembl
rs2128558863	1957	G>A		No	Ensembl
rs2128558863	1957	G>E		No	Ensembl
rs2128558870	1957	G>R		No	Ensembl
rs2128558863	1957	G>V		No	Ensembl
rs986549979	1958	E>*		No	TOPMed
rs2128558846	1958	E>D		No	Ensembl
rs1776173488	1958	E>G		No	Ensembl
rs986549979	1958	E>K		No	TOPMed
rs986549979	1958	E>Q		No	TOPMed
rs1776173488	1958	E>V		No	Ensembl
rs2128558837	1959	V>A		No	Ensembl
rs2128558837	1959	V>E		No	Ensembl
rs2128558837	1959	V>G		No	Ensembl
rs2128558841	1959	V>L		No	Ensembl
rs2128558841	1959	V>M		No	Ensembl
rs2128558828	1960	Y>*		No	Ensembl
rs138420858	1960	Y>C		No	1000Genomes ExAC gnomAD
rs2128558832	1960	Y>D		No	Ensembl
rs138420858	1960	Y>F		No	1000Genomes ExAC gnomAD
COSM4868810 COSM1072520	1960	Y>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128558832	1960	Y>N		No	Ensembl
rs2128558824	1961	E>*		No	Ensembl
rs2128558817	1961	E>A		No	Ensembl
rs2128558810	1961	E>D		No	Ensembl
rs2128558817	1961	E>G		No	Ensembl
rs2128558824	1961	E>K		No	Ensembl
rs2128558824	1961	E>Q		No	Ensembl
rs2128558817	1961	E>V		No	Ensembl
rs751153523	1962	G>A		No	ExAC TOPMed gnomAD
rs751153523	1962	G>E		No	ExAC TOPMed gnomAD
rs2128558804	1962	G>R		No	Ensembl
rs751153523	1962	G>V		No	ExAC TOPMed gnomAD
rs1455810428	1963	T>I		No	TOPMed gnomAD
rs1455810428	1963	T>K		No	TOPMed gnomAD
rs1455810428	1963	T>R		No	TOPMed gnomAD
rs2128558791	1963	T>S		No	Ensembl
rs2128558772	1964	A>E		No	Ensembl
rs2128558772	1964	A>G		No	Ensembl
rs766115237	1964	A>P		No	ExAC TOPMed gnomAD
COSM284673 COSM284674 rs766115237	1964	A>T	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs2128558772	1964	A>V		No	Ensembl
rs2128558758	1965	V>A		No	Ensembl
rs2128558758	1965	V>E		No	Ensembl
rs2128558764	1965	V>L		No	Ensembl
rs2128558764	1965	V>M		No	Ensembl
rs2128558739	1966	D>E		No	Ensembl
rs2128558746	1966	D>H		No	Ensembl
rs2128558746	1966	D>N		No	Ensembl
rs2128558746	1966	D>Y		No	Ensembl
rs765711132	1967	I>F		No	ExAC gnomAD
rs2128558728	1967	I>M		No	Ensembl
rs1486456431	1967	I>N		No	TOPMed
rs765711132	1967	I>V		No	ExAC gnomAD
rs2128558718	1968	L>*		No	Ensembl
rs2128558727	1968	L>I		No	Ensembl
rs1776170037	1969	G>R		No	TOPMed
rs2128558707	1969	G>V		No	Ensembl
rs371159504	1970	V>A		No	ESP ExAC TOPMed gnomAD
rs371159504	1970	V>D		No	ESP ExAC TOPMed gnomAD
rs371159504	1970	V>G		No	ESP ExAC TOPMed gnomAD
rs2128558700	1970	V>I		No	Ensembl
rs2128558700	1970	V>L		No	Ensembl
rs2128558680	1971	G>A		No	Ensembl
rs2128558680	1971	G>E		No	Ensembl
rs760855335	1971	G>R		No	ExAC TOPMed gnomAD
rs2128558680	1971	G>V		No	Ensembl
rs2128558671	1972	S>C		No	Ensembl
rs2128558671	1972	S>G		No	Ensembl
rs1332539257	1972	S>I		No	gnomAD
rs1332539257	1972	S>N		No	gnomAD
rs2128558658	1972	S>R		No	Ensembl
rs1332539257	1972	S>T		No	gnomAD
rs1216964547	1973	G>*		No	Ensembl
rs2128558644	1973	G>A		No	Ensembl
rs2128558644	1973	G>E		No	Ensembl
rs1216964547	1973	G>R		No	Ensembl
rs2128558644	1973	G>V		No	Ensembl
rs2128558637	1974	E>G		No	Ensembl
COSM3857782 COSM3857781	1974	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs146653150	1975	I>M		No	ESP ExAC TOPMed gnomAD
rs1776167165	1975	I>V		No	Ensembl
rs2128558615	1976	K>E		No	Ensembl
rs2128558612	1976	K>I		No	Ensembl
rs2128558612	1976	K>T		No	Ensembl
rs145889490	1977	V>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs145889490	1977	V>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128558588	1978	A>E		No	Ensembl
rs2128558588	1978	A>G		No	Ensembl
rs1373810021	1978	A>P		No	TOPMed
rs1373810021	1978	A>T		No	TOPMed
rs2128558588	1978	A>V		No	Ensembl
rs2128558575	1979	V>E		No	Ensembl
rs2128558575	1979	V>G		No	Ensembl
rs2128558582	1979	V>L		No	Ensembl
rs2128558582	1979	V>M		No	Ensembl
rs377281534	1980	K>E		No	ESP ExAC TOPMed gnomAD
rs1432927530	1980	K>M		No	gnomAD
rs2128558551	1980	K>N		No	Ensembl
rs377281534	1980	K>Q		No	ESP ExAC TOPMed gnomAD
rs1432927530	1980	K>R		No	gnomAD
rs994343717	1981	T>I		No	Ensembl
rs768571352	1981	T>P		No	ExAC gnomAD
COSM1440046 rs768571352 COSM1440047	1981	T>S	large_intestine [Cosmic]	No	cosmic curated ExAC gnomAD
rs994343717 COSM1440046 COSM1440047	1981	T>S	large_intestine [Cosmic]	No	cosmic curated Ensembl
rs2128556977	1982	L>F		No	Ensembl
rs2128556974	1983	K>N		No	Ensembl
rs2128556970	1984	K>M		No	Ensembl
rs2128556967	1984	K>N		No	Ensembl
rs2128556970	1984	K>R		No	Ensembl
rs2128556963	1985	G>C		No	Ensembl
rs2128556963	1985	G>S		No	Ensembl
rs2128556954	1986	S>C		No	Ensembl
rs2128556954	1986	S>F		No	Ensembl
rs1776055528	1986	S>T		No	TOPMed
rs2128556954	1986	S>Y		No	Ensembl
rs746934594	1987	T>A		No	ExAC TOPMed gnomAD
rs758011864	1987	T>I		No	ExAC TOPMed gnomAD
rs758011864	1987	T>K		No	ExAC TOPMed gnomAD
rs1776054678	1988	D>E		No	TOPMed
rs745485549	1988	D>G		No	ExAC gnomAD
rs2128556943	1988	D>H		No	Ensembl
rs2128556943	1988	D>N		No	Ensembl
rs745485549	1988	D>V		No	ExAC gnomAD
rs2128556943	1988	D>Y		No	Ensembl
rs1351039722	1989	Q>*		No	gnomAD
rs1351039722	1989	Q>E		No	gnomAD
rs139620900	1989	Q>H		No	ESP ExAC TOPMed gnomAD
rs1351039722	1989	Q>K		No	gnomAD
rs1776053836	1990	E>*		No	Ensembl
rs2128556917	1990	E>D		No	Ensembl
rs1776053836	1990	E>K		No	Ensembl
rs1776053836	1990	E>Q		No	Ensembl
rs2128556907	1991	K>N		No	Ensembl
rs2128556915	1991	K>Q		No	Ensembl
rs2128556912	1991	K>R		No	Ensembl
rs150992008	1992	I>N		No	ESP ExAC TOPMed gnomAD
rs150992008	1992	I>S		No	ESP ExAC TOPMed gnomAD
rs150992008	1992	I>T		No	ESP ExAC TOPMed gnomAD
rs906320421	1992	I>V		No	TOPMed
rs2128556891	1993	E>*		No	Ensembl
rs1040011127	1993	E>A		No	TOPMed
rs1040011127	1993	E>G		No	TOPMed
rs2128556891	1993	E>K		No	Ensembl
rs2128556891	1993	E>Q		No	Ensembl
rs2128556885	1994	F>I		No	Ensembl
rs375091643	1994	F>L		No	ESP ExAC TOPMed gnomAD
rs2128556882	1994	F>Y		No	Ensembl
rs2128556875	1995	L>P		No	Ensembl
rs2128556875	1995	L>Q		No	Ensembl
rs2128556867	1996	K>*		No	Ensembl
rs2128556862	1996	K>N		No	Ensembl
rs1318185001	1996	K>R		No	TOPMed gnomAD
rs2128556847	1998	A>G		No	Ensembl
rs1383276210	1998	A>P		No	TOPMed gnomAD
rs1383276210	1998	A>S		No	TOPMed gnomAD
rs1383276210	1998	A>T		No	TOPMed gnomAD
rs2128556847	1998	A>V		No	Ensembl
rs756583901	1999	H>L		No	ExAC gnomAD
VAR_041455 rs45569132	1999	H>N		No	UniProt ExAC TOPMed dbSNP gnomAD
rs2128556831	1999	H>Q		No	Ensembl
rs756583901	1999	H>R		No	ExAC gnomAD
rs2128556827	2000	L>P		No	Ensembl
rs2128556827	2000	L>Q		No	Ensembl
rs1461295528	2000	L>V		No	gnomAD
rs2128556809	2001	M>I		No	Ensembl
rs2128556814	2001	M>K		No	Ensembl
rs753178466	2002	S>C		No	ExAC gnomAD
rs753178466	2002	S>G		No	ExAC gnomAD
rs1776051397	2002	S>N		No	TOPMed
rs1775985958	2002	S>R		No	TOPMed gnomAD
rs1272626011	2003	K>E		No	gnomAD
VAR_041456	2003	K>R	a colorectal adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt
rs2128555814	2004	F>I		No	Ensembl
rs2128555812	2004	F>L		No	Ensembl
rs897773765	2005	N>I		No	TOPMed gnomAD
rs897773765	2005	N>S		No	TOPMed gnomAD
rs2128555808	2005	N>Y		No	Ensembl
rs2128555800	2006	H>D		No	Ensembl
rs2128555797	2006	H>L		No	Ensembl
rs763916632	2006	H>Q		No	ExAC TOPMed gnomAD
rs2128555800	2006	H>Y		No	Ensembl
rs760434481	2007	P>A		No	ExAC gnomAD
rs2128555792	2007	P>H		No	Ensembl
rs760434481	2007	P>S		No	ExAC gnomAD
rs760434481	2007	P>T		No	ExAC gnomAD
rs376237932	2008	N>I		No	ESP TOPMed gnomAD
rs2128555775	2008	N>K		No	Ensembl
rs376237932	2008	N>S		No	ESP TOPMed gnomAD
rs376237932	2008	N>T		No	ESP TOPMed gnomAD
rs2128555770	2009	I>F		No	Ensembl
rs2128555768	2009	I>N		No	Ensembl
rs2128555768	2009	I>S		No	Ensembl
rs1278741519	2010	L>M		No	gnomAD
rs1278741519	2010	L>V		No	gnomAD
rs1401547479	2011	K>*		No	TOPMed
rs2128555751	2011	K>M		No	Ensembl
rs2128555747	2011	K>N		No	Ensembl
rs1401547479	2011	K>Q		No	TOPMed
rs2128555745	2012	Q>*		No	Ensembl
rs2128555745	2012	Q>E		No	Ensembl
rs1234205299	2012	Q>H		No	gnomAD
rs2128555740	2012	Q>L		No	Ensembl
rs942065555	2013	L>F		No	TOPMed
rs2128555727	2013	L>H		No	Ensembl
rs942065555	2013	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs2128555727	2013	L>P		No	Ensembl
COSM1287693 COSM1287694 rs942065555	2013	L>V	Variant assessed as Somatic; MODERATE impact. autonomic_ganglia [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic TOPMed
rs2128555716	2014	G>*		No	Ensembl
rs2128555713	2014	G>A		No	Ensembl
rs2128555713	2014	G>E		No	Ensembl
rs2128555716	2014	G>R		No	Ensembl
rs2128555713	2014	G>V		No	Ensembl
rs2128555706	2015	V>A		No	Ensembl
rs2128555706	2015	V>D		No	Ensembl
rs2128555708	2015	V>I		No	Ensembl
rs2128555708	2015	V>L		No	Ensembl
rs2128555692	2016	C>*		No	Ensembl
rs2128555695	2016	C>S		No	Ensembl
rs1775983462	2016	C>S		No	TOPMed
rs2128555692	2016	C>W		No	Ensembl
rs2128555695	2016	C>Y		No	Ensembl
rs1332464408	2017	L>V		No	TOPMed gnomAD
rs2128555679	2018	L>Q		No	Ensembl
rs2128555681	2018	L>V		No	Ensembl
rs2128555669	2019	N>I		No	Ensembl
rs775554788	2019	N>K		No	ExAC gnomAD
rs2128555670	2019	N>Y		No	Ensembl
rs2128555663	2020	E>*		No	Ensembl
rs1440520941	2020	E>D		No	TOPMed gnomAD
rs2128555663	2020	E>K		No	Ensembl
rs2128555663	2020	E>Q		No	Ensembl
rs2128555661	2020	E>V		No	Ensembl
rs762511151	2021	P>A		No	TOPMed gnomAD
rs2128555654	2021	P>H		No	Ensembl
rs2128555654	2021	P>L		No	Ensembl
rs2128555654	2021	P>R		No	Ensembl
rs762511151	2021	P>S		No	TOPMed gnomAD
rs762511151	2021	P>T		No	TOPMed gnomAD
rs2128555647	2022	Q>*		No	Ensembl
rs2128555647	2022	Q>E		No	Ensembl
rs372757261	2022	Q>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128555647	2022	Q>K		No	Ensembl
rs2128555631	2023	Y>*		No	Ensembl
rs2128555635	2023	Y>C		No	Ensembl
rs2128555635	2023	Y>F		No	Ensembl
rs2128555641	2023	Y>N		No	Ensembl
rs2128555626	2024	I>N		No	Ensembl
rs2128555626	2024	I>T		No	Ensembl
rs1582600835	2024	I>V		No	Ensembl
rs2128555619	2025	I>F		No	Ensembl
rs2128555613	2025	I>M		No	Ensembl
rs2128555615	2025	I>N		No	Ensembl
rs2128555610	2026	L>M		No	Ensembl
rs2128555608	2026	L>P		No	Ensembl
rs2128555608	2026	L>Q		No	Ensembl
rs2128555610	2026	L>V		No	Ensembl
rs1775981779	2027	E>*		No	Ensembl
rs773937780	2027	E>D		No	ExAC gnomAD
rs1775981779	2027	E>K		No	Ensembl
rs1775981779	2027	E>Q		No	Ensembl
rs1434062038	2028	L>V		No	TOPMed gnomAD
rs2128555578	2029	M>I		No	Ensembl
rs1337321469	2029	M>K		No	TOPMed
rs199682124	2029	M>L		No	ExAC TOPMed gnomAD
rs1337321469	2029	M>T		No	TOPMed
TCGA novel rs2128555574	2030	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs575209344	2030	E>D		No	1000Genomes ExAC TOPMed gnomAD
rs2128555574	2030	E>K		No	Ensembl
rs2128555574	2030	E>Q		No	Ensembl
rs2128555565	2031	G>*		No	Ensembl
rs1468447100	2031	G>A		No	TOPMed gnomAD
rs1468447100	2031	G>E		No	TOPMed gnomAD
rs2128555565	2031	G>R		No	Ensembl
rs1468447100	2031	G>V		No	TOPMed gnomAD
rs1057519788	2032	G>*		No	Ensembl
rs777342450	2032	G>A		No	ExAC gnomAD
rs777342450	2032	G>E		No	ExAC gnomAD
rs777342450	2032	G>V		No	ExAC gnomAD
rs557108710	2033	D>E		No	1000Genomes ExAC TOPMed gnomAD
rs748581568	2033	D>G		No	ExAC TOPMed gnomAD
rs1484038087	2033	D>H		No	gnomAD
rs1484038087	2033	D>N		No	gnomAD
rs748581568	2033	D>V		No	ExAC TOPMed gnomAD
rs2128555531	2034	L>F		No	Ensembl
rs2128555530	2034	L>H		No	Ensembl
rs2128555530	2034	L>P		No	Ensembl
rs2128555531	2034	L>V		No	Ensembl
rs755420040	2035	L>F		No	ExAC TOPMed gnomAD
rs2128555524	2035	L>H		No	Ensembl
rs755420040	2035	L>V		No	ExAC TOPMed gnomAD
rs1775978954	2036	T>A		No	TOPMed
rs2128555510	2036	T>I		No	Ensembl
rs2128555510	2036	T>S		No	Ensembl
rs2128555501	2037	Y>H		No	Ensembl
rs1281394663	2038	L>F		No	TOPMed gnomAD
rs2128555497	2038	L>M		No	Ensembl
rs752085591	2039	R>C		No	ExAC TOPMed gnomAD
rs752085591	2039	R>G		No	ExAC TOPMed gnomAD
VAR_030654 rs3752566	2039	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	UniProt 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs3752566	2039	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs3752566	2039	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs752085591	2039	R>S		No	ExAC TOPMed gnomAD
rs2128555469	2040	K>I		No	Ensembl
rs2128555462	2040	K>N		No	Ensembl
rs2128555469	2040	K>R		No	Ensembl
rs1775978230	2041	A>D		No	TOPMed
rs1775978230	2041	A>G		No	TOPMed
rs1775978230	2041	A>V		No	TOPMed
rs758446263	2042	R>G		No	ExAC TOPMed gnomAD
rs369340872	2042	R>L		No	ESP ExAC TOPMed gnomAD
rs369340872	2042	R>Q		No	ESP ExAC TOPMed gnomAD
rs758446263	2042	R>W		No	ExAC TOPMed gnomAD
rs2128555441	2043	M>I		No	Ensembl
rs2128555445	2043	M>K		No	Ensembl
rs2128555449	2043	M>L		No	Ensembl
rs2128555445	2043	M>R		No	Ensembl
rs2128555449	2043	M>V		No	Ensembl
rs147277840	2044	A>P		No	ESP ExAC gnomAD
rs147277840	2044	A>S		No	ESP ExAC gnomAD
rs147277840	2044	A>T		No	ESP ExAC gnomAD
rs2128555435	2045	T>A		No	Ensembl
rs957947676	2045	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs957947676	2045	T>R		No	TOPMed gnomAD
rs2128555435	2045	T>S		No	Ensembl
rs2128550100	2046	F>I		No	Ensembl
COSM1647881 COSM739508 rs2128550096 COSM739509	2046	F>Y	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs2128550090	2047	Y>*		No	Ensembl
rs2128550086	2047	Y>F		No	Ensembl
rs1321755162	2047	Y>H		No	gnomAD
rs1321755162	2047	Y>N		No	gnomAD
rs2128550068	2048	G>A		No	Ensembl
rs2128550081	2048	G>C		No	Ensembl
rs2128550068	2048	G>D		No	Ensembl
rs2128550081	2048	G>R		No	Ensembl
rs2128550068	2048	G>V		No	Ensembl
rs2128550067	2049	P>A		No	Ensembl
rs1775511666 COSM3619820 COSM3619821	2049	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128550067	2049	P>S		No	Ensembl
rs1775511388	2050	L>F		No	Ensembl
rs2128550051	2051	L>H		No	Ensembl
rs2128550053	2051	L>V		No	Ensembl
rs529164211	2052	T>I		No	1000Genomes ExAC TOPMed gnomAD
rs529164211	2052	T>N		No	1000Genomes ExAC TOPMed gnomAD
rs1562259733	2052	T>P		No	Ensembl
rs529164211	2052	T>S		No	1000Genomes ExAC TOPMed gnomAD
rs1562259733	2052	T>S		No	Ensembl
rs766298478	2053	L>F		No	ExAC gnomAD
rs201894511	2054	V>F		No	ESP ExAC TOPMed gnomAD
rs201894511	2054	V>I		No	ESP ExAC TOPMed gnomAD
rs201894511	2054	V>L		No	ESP ExAC TOPMed gnomAD
rs1775509983	2055	D>E		No	TOPMed gnomAD
rs1775510174	2055	D>H		No	gnomAD
rs1775510174	2055	D>N		No	gnomAD
rs2128550014	2055	D>V		No	Ensembl
rs1775510174	2055	D>Y		No	gnomAD
rs1775509786	2056	L>F		No	gnomAD
rs2128549994	2056	L>H		No	Ensembl
rs1775509786	2056	L>I		No	gnomAD
rs2128549994	2056	L>P		No	Ensembl
rs1034471676	2057	V>A		No	TOPMed
rs1436986770	2057	V>I		No	gnomAD
rs1436986770	2057	V>L		No	gnomAD
rs2128549948	2058	D>E		No	Ensembl
rs764825728	2058	D>G		No	ExAC gnomAD
rs772539932	2058	D>H		No	ExAC gnomAD
rs772539932	2058	D>N		No	ExAC gnomAD
rs764825728	2058	D>V		No	ExAC gnomAD
rs772539932	2058	D>Y		No	ExAC gnomAD
TCGA novel	2059	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs761415842	2059	L>P		No	ExAC gnomAD
rs761415842	2059	L>Q		No	ExAC gnomAD
rs2128549941	2059	L>V		No	Ensembl
rs368003464	2060	C>*		No	ESP ExAC gnomAD
rs2128549911	2060	C>F		No	Ensembl
rs1393239973	2060	C>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs2128549911	2060	C>S		No	Ensembl
rs1393239973	2060	C>S		No	TOPMed gnomAD
TCGA novel	2061	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2128549892	2061	V>E		No	Ensembl
rs2128549900	2061	V>I		No	Ensembl
rs2128549900	2061	V>L		No	Ensembl
rs1775507652	2062	D>E		No	Ensembl
rs2128549875	2062	D>H		No	Ensembl
rs2128549875	2062	D>N		No	Ensembl
rs2128549872	2062	D>V		No	Ensembl
rs2128549875	2062	D>Y		No	Ensembl
rs2128549864	2063	I>F		No	Ensembl
rs193121244	2063	I>N		No	1000Genomes ExAC gnomAD
rs2128549848	2064	S>*		No	Ensembl
rs2128549848	2064	S>L		No	Ensembl
rs2128549852	2064	S>T		No	Ensembl
rs776060632	2065	K>*		No	ExAC gnomAD
rs776060632	2065	K>E		No	ExAC gnomAD
rs1775506664	2066	G>A		No	Ensembl
COSM6172043 COSM6172042	2066	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1775506664	2066	G>D		No	Ensembl
rs1775506664	2066	G>V		No	Ensembl
rs2128549811	2067	C>*		No	Ensembl
COSM3857777 COSM3857778	2067	C>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772393224	2067	C>R		No	ExAC gnomAD
rs772393224	2067	C>S		No	ExAC gnomAD
rs1775506273	2067	C>Y		No	TOPMed
rs2128549806	2068	V>I		No	Ensembl
rs2128549806	2068	V>L		No	Ensembl
rs1775505857	2069	Y>*		No	TOPMed
rs1190220728	2069	Y>C		No	gnomAD
rs1190220728	2069	Y>F		No	gnomAD
rs2128549802	2069	Y>N		No	Ensembl
rs1190220728	2069	Y>S		No	gnomAD
rs1488589803	2070	L>*		No	gnomAD
rs1488589803	2070	L>S		No	gnomAD
rs2128549787	2071	E>A		No	Ensembl
rs2128549782	2071	E>D		No	Ensembl
rs139881304	2072	R>G		No	1000Genomes ESP ExAC gnomAD
rs779401784	2072	R>L		No	ExAC TOPMed gnomAD
rs779401784	2072	R>P		No	ExAC TOPMed gnomAD
rs779401784	2072	R>Q		No	ExAC TOPMed gnomAD
rs139881304	2072	R>W		No	1000Genomes ESP ExAC gnomAD
rs2128549760	2073	M>I		No	Ensembl
rs1775505126	2073	M>K		No	Ensembl
rs2128549766	2073	M>L		No	Ensembl
rs1775505126	2073	M>R		No	Ensembl
rs2128549756	2074	H>D		No	Ensembl
rs1001750135	2074	H>L		No	Ensembl
rs1001750135	2074	H>P		No	Ensembl
rs1001750135	2074	H>R		No	Ensembl
rs2128549756	2074	H>Y		No	Ensembl
rs868183177	2075	F>L		No	Ensembl
rs1340913308	2077	H>L		No	gnomAD
rs2128549737	2077	H>Q		No	Ensembl
rs1340913308	2077	H>R		No	gnomAD
rs2128549735	2078	R>G		No	Ensembl
rs528528184	2078	R>K		No	1000Genomes
rs528528184	2078	R>M		No	1000Genomes
rs147454452	2078	R>S		No	ESP ExAC TOPMed gnomAD
rs528528184	2078	R>T		No	1000Genomes
COSM6172044 COSM6172045	2078	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128548761	2079	D>E		No	Ensembl
rs774960557	2079	D>G		No	ExAC TOPMed gnomAD
rs1416655668	2079	D>H		No	Ensembl
COSM1697815 rs1416655668 COSM1697816	2079	D>N	skin [Cosmic]	No	cosmic curated Ensembl
rs774960557	2079	D>V		No	ExAC TOPMed gnomAD
rs1416655668	2079	D>Y		No	Ensembl
rs2128548756	2080	L>P		No	Ensembl
rs2128548756	2080	L>Q		No	Ensembl
rs1166389096	2081	A>P		No	TOPMed gnomAD
rs1166389096	2081	A>S		No	TOPMed gnomAD
COSM1072514 COSM1072512 COSM4867723 rs1166389096	2081	A>T	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs2128548732	2082	A>D		No	Ensembl
rs2128548732	2082	A>G		No	Ensembl
rs2128548737	2082	A>P		No	Ensembl
rs2128548737	2082	A>T		No	Ensembl
TCGA novel rs2128548732	2082	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs552183	2083	R>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs749448229	2083	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1775438250	2084	N>D		No	Ensembl
rs2128548710	2084	N>I		No	Ensembl
rs2128548703	2084	N>K		No	Ensembl
rs1775438250	2084	N>Y		No	Ensembl
rs1775437483	2085	C>F		No	Ensembl
rs770087460	2085	C>G		No	ExAC gnomAD
rs770087460	2085	C>R		No	ExAC gnomAD
rs770087460	2085	C>S		No	ExAC gnomAD
rs1775437483	2085	C>S		No	Ensembl
rs1775437272	2085	C>W		No	TOPMed
rs1775437483	2085	C>Y		No	Ensembl
rs1775437042	2086	L>F		No	TOPMed
rs2128548686	2086	L>H		No	Ensembl
rs1775437042	2086	L>I		No	TOPMed
rs1775437042	2086	L>V		No	TOPMed
rs779674711	2087	V>A		No	ExAC gnomAD
rs779674711	2087	V>D		No	ExAC gnomAD
rs748425390	2087	V>F		No	ExAC TOPMed gnomAD
rs779674711	2087	V>G		No	ExAC gnomAD
rs748425390	2087	V>I		No	ExAC TOPMed gnomAD
rs748425390	2087	V>L		No	ExAC TOPMed gnomAD
rs2128548665 COSM3619819 COSM3619818	2088	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128548667	2088	S>P		No	Ensembl
rs2128548652	2089	V>E		No	Ensembl
rs2128548652	2089	V>G		No	Ensembl
rs750308356	2089	V>L		No	ExAC TOPMed gnomAD
COSM4722425 COSM4722426 rs750308356	2089	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs2128548644	2090	K>*		No	Ensembl
rs2128548638	2090	K>I		No	Ensembl
rs2128548626	2091	D>E		No	Ensembl
rs778877637	2091	D>G		No	ExAC TOPMed gnomAD
rs1775435625	2091	D>H		No	gnomAD
rs1775435625	2091	D>N		No	gnomAD
rs778877637	2091	D>V		No	ExAC TOPMed gnomAD
rs1775435625	2091	D>Y		No	gnomAD
rs2128548617	2092	Y>*		No	Ensembl
COSM1647883 COSM739515	2092	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128548620	2092	Y>F		No	Ensembl
rs2128548622	2092	Y>N		No	Ensembl
rs2128548610	2093	T>A		No	Ensembl
rs1775435080	2093	T>I		No	TOPMed gnomAD
rs1775435080	2093	T>N		No	TOPMed gnomAD
rs1775435080	2093	T>S		No	TOPMed gnomAD
rs2128548610	2093	T>S		No	Ensembl
rs1225166807	2094	S>G		No	gnomAD
rs2128548594	2094	S>I		No	Ensembl
rs2128548594	2094	S>N		No	Ensembl
rs2128548589	2094	S>R		No	Ensembl
rs2128548594	2094	S>T		No	Ensembl
rs2128548582	2095	P>L		No	Ensembl
rs2128548582	2095	P>R		No	Ensembl
rs1775434448	2095	P>S		No	TOPMed
rs371087942	2096	R>G		No	ESP ExAC TOPMed gnomAD
rs1022614558	2096	R>L		No	TOPMed gnomAD
rs1022614558	2096	R>P		No	TOPMed gnomAD
COSM3857775 COSM3857776 rs1022614558	2096	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs371087942 COSM4871660 COSM1072511 COSM1072509	2096	R>W	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs753277535	2097	I>K		No	ExAC gnomAD
rs2128548563	2097	I>L		No	Ensembl
rs2128548550	2097	I>M		No	Ensembl
rs753277535	2097	I>R		No	ExAC gnomAD
rs753277535	2097	I>T		No	ExAC gnomAD
rs2128548563	2097	I>V		No	Ensembl
rs2128548536	2098	V>A		No	Ensembl
rs2128548536	2098	V>E		No	Ensembl
rs2128548536	2098	V>G		No	Ensembl
rs2128548542	2098	V>L		No	Ensembl
rs2128548542	2098	V>M		No	Ensembl
rs1231534643	2099	K>N		No	TOPMed gnomAD
rs1775433158	2100	I>F		No	Ensembl
rs763607384	2100	I>M		No	ExAC gnomAD
rs1775432981	2100	I>N		No	Ensembl
rs1775432981	2100	I>S		No	Ensembl
rs1775432981	2100	I>T		No	Ensembl
rs2128548505	2101	G>*		No	Ensembl
rs2128548497	2101	G>A		No	Ensembl
rs2128548497	2101	G>E		No	Ensembl
rs2128548505	2101	G>R		No	Ensembl
rs2128548497	2101	G>V		No	Ensembl
rs760267537	2102	D>E		No	ExAC TOPMed gnomAD
rs2128548484	2102	D>G		No	Ensembl
rs2128548486	2102	D>H		No	Ensembl
rs2128548486	2102	D>N		No	Ensembl
rs2128548484	2102	D>V		No	Ensembl
rs2128548471	2103	F>I		No	Ensembl
rs2128548467	2103	F>S		No	Ensembl
rs1775432135	2104	G>*		No	gnomAD
rs1681569421	2104	G>A		No	gnomAD
rs1681569421	2104	G>E		No	gnomAD
rs1775432135	2104	G>R		No	gnomAD
rs1681569421	2104	G>V		No	gnomAD
rs1322389853	2105	L>F		No	Ensembl
rs1012650170	2105	L>H		No	Ensembl
rs1012650170	2105	L>P		No	Ensembl
rs1322389853	2105	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs2128548421	2106	A>D		No	Ensembl
rs2128548421	2106	A>G		No	Ensembl
rs150262256	2106	A>P		No	ESP ExAC TOPMed gnomAD
rs150262256	2106	A>S		No	ESP ExAC TOPMed gnomAD
rs150262256 COSM76280 COSM4947626	2106	A>T	ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs2128548421	2106	A>V		No	Ensembl
rs1775430553	2107	R>G		No	TOPMed
rs2128548398	2107	R>K		No	Ensembl
rs2128548393	2107	R>S		No	Ensembl
rs2128548398	2107	R>T		No	Ensembl
rs2128548373	2108	D>E		No	Ensembl
rs563507203	2108	D>G		No	1000Genomes ExAC TOPMed gnomAD
rs2128548388	2108	D>H		No	Ensembl
rs2128548388	2108	D>N		No	Ensembl
rs563507203	2108	D>V		No	1000Genomes ExAC TOPMed gnomAD
rs2128548388	2108	D>Y		No	Ensembl
rs2128548358	2109	I>M		No	Ensembl
rs2128548363	2109	I>N		No	Ensembl
rs1582578695	2109	I>V		No	Ensembl
rs2128548346	2110	Y>*		No	Ensembl
rs763571645	2110	Y>C		No	ExAC TOPMed gnomAD
rs2128548355 TCGA novel	2110	Y>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs763571645	2110	Y>S		No	ExAC TOPMed gnomAD
rs2128548344	2111	K>*		No	Ensembl
rs2128548340	2111	K>I		No	Ensembl
rs773381586	2111	K>N		No	ExAC gnomAD
rs770025086	2112	N>D		No	ExAC TOPMed gnomAD
rs2128548323	2112	N>I		No	Ensembl
rs770025086	2112	N>Y		No	ExAC TOPMed gnomAD
rs2128548313	2113	D>E		No	Ensembl
rs2128548316	2113	D>H		No	Ensembl
rs2128548316	2113	D>N		No	Ensembl
rs748287694	2113	D>V		No	ExAC gnomAD
rs2128548309	2114	Y>*		No	Ensembl
rs201206180	2114	Y>C		No	1000Genomes ExAC gnomAD
rs745741484	2115	Y>*		No	ExAC gnomAD
rs150994413	2115	Y>C		No	1000Genomes ExAC TOPMed gnomAD
rs150994413	2115	Y>F		No	1000Genomes ExAC TOPMed gnomAD
rs2128548300	2115	Y>H		No	Ensembl
rs2128548300	2115	Y>N		No	Ensembl
rs2128548291	2116	R>*		No	Ensembl
rs2128548287	2116	R>I		No	Ensembl
rs2128548283	2116	R>S		No	Ensembl
rs2128548287	2116	R>T		No	Ensembl
rs1484526625	2117	K>Q		No	TOPMed
rs778683218	2118	R>S		No	ExAC gnomAD
rs757128233	2119	G>E		No	ExAC gnomAD
rs2128548262	2119	G>R		No	Ensembl
rs2128548262	2119	G>W		No	Ensembl
rs2128548241	2120	E>D		No	Ensembl
rs2128548245	2120	E>G		No	Ensembl
rs2128548249	2120	E>K		No	Ensembl
rs2128548249	2120	E>Q		No	Ensembl
rs2128548245	2120	E>V		No	Ensembl
rs749246490	2121	G>A		No	ExAC gnomAD
rs1305422933	2121	G>C		No	gnomAD
rs749246490	2121	G>D		No	ExAC gnomAD
rs1305422933	2121	G>S		No	gnomAD
rs749246490	2121	G>V		No	ExAC gnomAD
rs2128548215	2122	L>Q		No	Ensembl
rs2128548220	2122	L>V		No	Ensembl
rs886941681	2123	L>F		No	Ensembl
rs2128548191	2123	L>H		No	Ensembl
rs2128548191	2123	L>P		No	Ensembl
rs886941681	2123	L>V		No	Ensembl
rs2128548183	2124	P>A		No	Ensembl
rs752266755	2124	P>L		No	ExAC gnomAD
rs2128548183	2124	P>S		No	Ensembl
rs2128548183	2124	P>T		No	Ensembl
rs2128548165	2125	V>A		No	Ensembl
rs2128548165	2125	V>D		No	Ensembl
rs1355678032	2125	V>F		No	TOPMed gnomAD
rs2128548165	2125	V>G		No	Ensembl
COSM139666 rs1355678032	2125	V>I	skin [Cosmic]	No	cosmic curated TOPMed gnomAD
rs1355678032	2125	V>L		No	TOPMed gnomAD
rs138376257 COSM1559724 COSM1559725	2126	R>G	central_nervous_system [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs199882276	2126	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs199882276	2126	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
RCV000880789 rs199882276	2126	R>Q		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs138376257 COSM227019 COSM227020	2126	R>W	skin [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs2128548137 COSM1697814 COSM1697813	2127	W>*	skin [Cosmic]	No	cosmic curated Ensembl
COSM1697814 rs2128548131 COSM1697813	2127	W>*	skin [Cosmic]	No	cosmic curated Ensembl
rs2128548131	2127	W>C		No	Ensembl
rs1321959715	2127	W>G		No	gnomAD
rs1321959715	2127	W>R		No	gnomAD
rs1775424027	2128	M>I		No	Ensembl
rs1775424227	2128	M>K		No	TOPMed
rs1775424227	2128	M>R		No	TOPMed
rs1402698762	2128	M>V		No	TOPMed gnomAD
rs1775423828	2129	A>P		No	TOPMed
rs1775423828	2129	A>S		No	TOPMed
rs1775423828	2129	A>T		No	TOPMed
rs1297604319	2129	A>V		No	TOPMed gnomAD
rs2128548104	2130	P>A		No	Ensembl
rs2128548088	2130	P>L		No	Ensembl
rs2128548088	2130	P>Q		No	Ensembl
rs2128548088	2130	P>R		No	Ensembl
rs2128548104	2130	P>S		No	Ensembl
rs2128548104	2130	P>T		No	Ensembl
COSM4893814 COSM4893815	2131	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128548084	2131	E>K		No	Ensembl
rs2128548084	2131	E>Q		No	Ensembl
rs2128548075	2132	S>C		No	Ensembl
rs2128548075	2132	S>G		No	Ensembl
rs773896715	2132	S>I		No	1000Genomes ExAC TOPMed gnomAD
COSM3619816 COSM3619817 rs773896715	2132	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC TOPMed gnomAD
rs2128548061	2132	S>R		No	Ensembl
rs773896715	2132	S>T		No	1000Genomes ExAC TOPMed gnomAD
rs1582578243	2133	L>*		No	gnomAD
rs2128548046	2133	L>F		No	Ensembl
rs765386753	2133	L>M		No	ExAC gnomAD
rs1582578243	2133	L>W		No	gnomAD
rs2128548033	2134	M>I		No	Ensembl
rs762013317	2134	M>K		No	ExAC TOPMed gnomAD
rs1775422675	2134	M>L		No	Ensembl
rs762013317	2134	M>T		No	ExAC TOPMed gnomAD
rs1775422675	2134	M>V		No	Ensembl
rs1163300111	2135	D>E		No	gnomAD
rs376507701	2135	D>G		No	ESP ExAC TOPMed gnomAD
rs2128548027	2135	D>H		No	Ensembl
rs2128548027	2135	D>N		No	Ensembl
rs376507701	2135	D>V		No	ESP ExAC TOPMed gnomAD
rs2128548027	2135	D>Y		No	Ensembl
COSM5902807 COSM5902806 rs1459053852	2136	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	gnomAD NCI-TCGA Cosmic NCI-TCGA
rs1158125322	2137	I>L		No	gnomAD
rs1305518433	2137	I>M		No	TOPMed gnomAD
rs2128548007	2137	I>N		No	Ensembl
rs747208320	2138	F>I		No	ExAC gnomAD
rs2128547984 COSM1440040 COSM1440041	2138	F>L	large_intestine [Cosmic]	No	cosmic curated Ensembl
COSM1440040 COSM1440041 rs747208320	2138	F>L	large_intestine [Cosmic]	No	cosmic curated ExAC gnomAD
VAR_041457	2138	F>S	a gastric adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt
COSM1440043 COSM1440042 rs747208320	2138	F>V	large_intestine [Cosmic]	No	cosmic curated ExAC gnomAD
rs2128547988	2138	F>Y		No	Ensembl
rs774083623	2140	T>A		No	ExAC gnomAD
rs2128547966	2140	T>I		No	Ensembl
rs774083623	2140	T>P		No	ExAC gnomAD
rs2128547966	2140	T>S		No	Ensembl
rs774083623	2140	T>S		No	ExAC gnomAD
rs770739791	2141	Q>*		No	ExAC gnomAD
COSM3857774 COSM3857773	2141	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128547957	2141	Q>L		No	Ensembl
rs2128547943	2142	S>C		No	Ensembl
rs2128547943	2142	S>F		No	Ensembl
rs2128547943	2142	S>Y		No	Ensembl
rs2128547925	2143	D>E		No	Ensembl
rs2128547932	2143	D>H		No	Ensembl
rs2128547932	2143	D>N		No	Ensembl
rs2128547927	2143	D>V		No	Ensembl
rs2128547932	2143	D>Y		No	Ensembl
rs2128547914	2144	V>A		No	Ensembl
rs2128547914	2144	V>E		No	Ensembl
rs749189360 COSM739516 COSM1647884 COSM739517	2144	V>I	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs749189360	2144	V>L		No	ExAC gnomAD
rs2128546443	2145	W>*		No	Ensembl
rs755564042	2145	W>*		No	ExAC TOPMed gnomAD
rs2128546443	2145	W>C		No	Ensembl
rs2128547905	2145	W>R		No	Ensembl
rs2128546433	2146	S>C		No	Ensembl
rs2128546433	2146	S>F		No	Ensembl
rs760847633	2146	S>P		No	ExAC gnomAD
rs760847633	2146	S>T		No	ExAC gnomAD
rs2128546433	2146	S>Y		No	Ensembl
rs2128546427	2147	F>L		No	Ensembl
rs2128546417	2148	G>A		No	Ensembl
COSM5910528 COSM5910529 rs2128546417	2148	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128546417	2148	G>V		No	Ensembl
rs2128546408	2149	I>F		No	Ensembl
rs1285782510	2149	I>N		No	gnomAD
rs1285782510	2149	I>S		No	gnomAD
rs1285782510	2149	I>T		No	gnomAD
rs2128546395	2150	L>Q		No	Ensembl
rs2128546382 COSM95206	2151	I>F	lung [Cosmic]	No	cosmic curated Ensembl
rs2128546380	2151	I>N		No	Ensembl
rs2128546382	2151	I>V		No	Ensembl
rs2128546357	2152	W>*		No	Ensembl
rs2128546364	2152	W>*		No	Ensembl
rs2128546357	2152	W>C		No	Ensembl
rs2128546364	2152	W>L		No	Ensembl
rs1310146010	2152	W>R		No	TOPMed
rs2128546364	2152	W>S		No	Ensembl
rs1775321457	2153	E>*		No	TOPMed gnomAD
rs1775321187	2153	E>D		No	TOPMed gnomAD
rs1775321457	2153	E>K		No	TOPMed gnomAD
rs2128546344	2154	I>F		No	Ensembl
rs1278895252	2154	I>N		No	gnomAD
rs1278895252	2154	I>T		No	gnomAD
rs1346166157	2155	L>*		No	gnomAD
COSM3619814 COSM3619815	2155	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs775729194	2155	L>I		No	ExAC gnomAD
rs1346166157	2155	L>S		No	gnomAD
rs2128546313	2156	T>I		No	Ensembl
rs2128546319	2156	T>S		No	Ensembl
rs2128546313	2156	T>S		No	Ensembl
rs2128546308	2157	L>F		No	Ensembl
rs1775320283	2157	L>H		No	TOPMed
rs1775320283	2157	L>P		No	TOPMed
rs1775320283	2157	L>R		No	TOPMed
rs2128546308	2157	L>V		No	Ensembl
rs2128546279	2158	G>A		No	Ensembl
rs2128546285	2158	G>C		No	Ensembl
rs2128546279	2158	G>D		No	Ensembl
rs2128546285	2158	G>R		No	Ensembl
rs2128546285 COSM3783928 COSM3783927	2158	G>S	Variant assessed as Somatic; MODERATE impact. prostate [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs2128546279	2158	G>V		No	Ensembl
rs770688968	2159	H>D		No	ExAC TOPMed gnomAD
rs749138188	2159	H>L		No	ExAC gnomAD
rs770688968	2159	H>N		No	ExAC TOPMed gnomAD
rs1775319690	2159	H>Q		No	Ensembl
rs749138188	2159	H>R		No	ExAC gnomAD
rs770688968	2159	H>Y		No	ExAC TOPMed gnomAD
rs2128546253	2160	Q>*		No	Ensembl
rs2128546253	2160	Q>E		No	Ensembl
rs2128546244	2160	Q>H		No	Ensembl
rs2128546250	2160	Q>L		No	Ensembl
rs2128546240	2161	P>A		No	Ensembl
rs772998388	2161	P>H		No	ExAC gnomAD
rs772998388	2161	P>L		No	ExAC gnomAD
rs772998388	2161	P>R		No	ExAC gnomAD
rs2128546240	2161	P>S		No	Ensembl
rs748058744	2162	Y>D		No	ExAC gnomAD
rs748058744	2162	Y>H		No	ExAC gnomAD
rs748058744	2162	Y>N		No	ExAC gnomAD
rs2128546205	2163	P>A		No	Ensembl
TCGA novel rs2128546196	2163	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128546196	2163	P>Q		No	Ensembl
rs2128546196	2163	P>R		No	Ensembl
rs2128546205	2163	P>S		No	Ensembl
rs2128546205	2163	P>T		No	Ensembl
rs2128546187	2164	A>D		No	Ensembl
rs2128546187	2164	A>G		No	Ensembl
rs1740235982	2164	A>P		No	TOPMed gnomAD
rs1740235982	2164	A>S		No	TOPMed gnomAD
rs1740235982	2164	A>T		No	TOPMed gnomAD
rs2128546187	2164	A>V		No	Ensembl
rs780713592	2165	H>D		No	ExAC gnomAD
rs2128546174	2165	H>L		No	Ensembl
rs780713592	2165	H>N		No	ExAC gnomAD
rs2128546168	2165	H>Q		No	Ensembl
rs780713592	2165	H>Y		No	ExAC gnomAD
rs2128546164	2166	S>A		No	Ensembl
rs976517290	2166	S>C		No	Ensembl
rs976517290	2166	S>F		No	Ensembl
rs976517290	2166	S>Y		No	Ensembl
rs2128546150	2167	N>I		No	Ensembl
rs374358403	2167	N>K		No	ESP ExAC TOPMed gnomAD
rs2128546150	2167	N>T		No	Ensembl
rs746642345	2168	L>F		No	ExAC gnomAD
rs1775317741	2168	L>H		No	gnomAD
rs746642345	2168	L>I		No	ExAC gnomAD
rs1775317741	2168	L>P		No	gnomAD
rs746642345	2168	L>V		No	ExAC gnomAD
rs2128546102	2169	D>G		No	Ensembl
rs2128546111	2169	D>H		No	Ensembl
rs2128546111	2169	D>N		No	Ensembl
rs2128546102	2169	D>V		No	Ensembl
rs2128546111	2169	D>Y		No	Ensembl
rs2128546081	2170	V>E		No	Ensembl
rs2128546089	2170	V>L		No	Ensembl
rs2128546089	2170	V>M		No	Ensembl
rs2128546062	2171	L>*		No	Ensembl
rs2128546059	2171	L>F		No	Ensembl
rs2128546070	2171	L>I		No	Ensembl
rs2128546062	2171	L>S		No	Ensembl
rs758832763	2172	N>H		No	ExAC gnomAD
rs750748780	2172	N>I		No	ExAC gnomAD
rs2128546047	2172	N>K		No	Ensembl
rs750748780	2172	N>S		No	ExAC gnomAD
rs758832763	2172	N>Y		No	ExAC gnomAD
rs2128546031	2173	Y>*		No	Ensembl
rs377356164	2173	Y>C		No	ESP ExAC TOPMed gnomAD
rs377356164	2173	Y>F		No	ESP ExAC TOPMed gnomAD
rs182529844	2173	Y>N		No	1000Genomes ExAC TOPMed gnomAD
rs377356164	2173	Y>S		No	ESP ExAC TOPMed gnomAD
rs754329824	2174	V>E		No	ExAC gnomAD
rs2128546022	2174	V>L		No	Ensembl
rs2128546022	2174	V>M		No	Ensembl
rs764203432	2175	Q>*		No	ExAC gnomAD
rs764203432	2175	Q>E		No	ExAC gnomAD
rs764203432	2175	Q>K		No	ExAC gnomAD
rs1440090931	2176	T>I		No	TOPMed
rs2128546012	2176	T>P		No	Ensembl
rs1440090931	2176	T>R		No	TOPMed
rs1775315228	2177	G>A		No	Ensembl
rs1775315228	2177	G>E		No	Ensembl
rs2128546003	2177	G>R		No	Ensembl
rs1775315228	2177	G>V		No	Ensembl
rs2128545990	2178	G>A		No	Ensembl
rs2128545990	2178	G>E		No	Ensembl
rs2128545994	2178	G>R		No	Ensembl
rs2128545990	2178	G>V		No	Ensembl
rs1775315045	2179	R>I		No	TOPMed
rs1775315045	2179	R>K		No	TOPMed
rs2128545976	2179	R>S		No	Ensembl
rs1775315045	2179	R>T		No	TOPMed
rs2128545972	2180	L>M		No	Ensembl
rs2128545969	2180	L>Q		No	Ensembl
rs2128545969	2180	L>R		No	Ensembl
rs2128545972	2180	L>V		No	Ensembl
rs1281192538	2181	E>D		No	gnomAD
COSM3619812 COSM3619813 rs2128545962	2181	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128545962	2181	E>Q		No	Ensembl
rs760792633	2182	P>A		No	ExAC gnomAD
COSM4992398 rs760792633 COSM4992399	2182	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs760792633	2182	P>T		No	ExAC gnomAD
rs767792683	2183	P>A		No	ExAC gnomAD
rs2128545939	2183	P>L		No	Ensembl
rs2128545939	2183	P>Q		No	Ensembl
rs2128545939	2183	P>R		No	Ensembl
rs767792683	2183	P>S		No	ExAC gnomAD
rs767792683	2183	P>T		No	ExAC gnomAD
rs1224719700	2184	R>*		No	TOPMed gnomAD
COSM169762 rs2128545926 COSM169763 COSM1672706	2184	R>I	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
COSM3429909 COSM3429910 rs2128545926	2184	R>K	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs2128545926	2184	R>T		No	Ensembl
rs2128545921	2185	N>D		No	Ensembl
rs2128545918	2185	N>I		No	Ensembl
rs1018137213	2185	N>K		No	TOPMed gnomAD
rs2128545904	2186	C>*		No	Ensembl
rs759768879	2186	C>F		No	ExAC gnomAD
rs1775313296	2186	C>S		No	TOPMed gnomAD
rs1775312906	2187	P>A		No	gnomAD
rs1775312906	2187	P>S		No	gnomAD
COSM314883 COSM314884 rs1775312906	2187	P>T	lung [Cosmic]	No	cosmic curated gnomAD
COSM1650497 COSM6104793 COSM594218 rs2128545883 COSM6104792 COSM594217	2188	D>G	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic Ensembl
COSM351311 COSM351312 rs1367476083	2188	D>H	lung [Cosmic]	No	cosmic curated gnomAD
rs1367476083	2188	D>N		No	gnomAD
rs2128545883	2188	D>V		No	Ensembl
rs2128545874	2189	D>G		No	Ensembl
rs2128545878	2189	D>H		No	Ensembl
rs2128545878 COSM1697812 COSM1697811	2189	D>N	skin [Cosmic]	No	cosmic curated Ensembl
rs2128545874	2189	D>V		No	Ensembl
rs2128545865	2190	L>Q		No	Ensembl
rs2128545870	2190	L>V		No	Ensembl
rs2128537293	2191	W>*		No	Ensembl
rs776629258	2191	W>*		No	ExAC TOPMed gnomAD
rs2128537293	2191	W>C		No	Ensembl
rs776629258	2191	W>L		No	ExAC TOPMed gnomAD
rs776629258	2191	W>S		No	ExAC TOPMed gnomAD
rs2128537291	2192	N>I		No	Ensembl
rs2128537287	2192	N>K		No	Ensembl
rs2128537281	2193	L>F		No	Ensembl
rs1213243422	2194	M>I		No	TOPMed gnomAD
rs2128537271	2194	M>K		No	Ensembl
rs2128537271	2194	M>T		No	Ensembl
rs2128537276	2194	M>V		No	Ensembl
rs768649987	2195	T>A		No	ExAC TOPMed gnomAD
rs140284927	2195	T>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs140284927	2195	T>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs768649987	2195	T>S		No	ExAC TOPMed gnomAD
rs2128537231	2196	Q>*		No	Ensembl
rs2128537231	2196	Q>E		No	Ensembl
rs2128537223	2196	Q>H		No	Ensembl
rs2128537217	2197	C>G		No	Ensembl
rs2128537217	2197	C>S		No	Ensembl
rs2128537211	2197	C>S		No	Ensembl
rs1459039958	2197	C>W		No	gnomAD
rs2128537211	2197	C>Y		No	Ensembl
rs775088466	2198	W>*		No	ExAC gnomAD
rs2128537189	2198	W>*		No	Ensembl
rs2128537189	2198	W>C		No	Ensembl
rs2128537205	2198	W>G		No	Ensembl
rs2128537205	2198	W>R		No	Ensembl
rs775088466	2198	W>S		No	ExAC gnomAD
rs1164131685	2200	Q>*		No	TOPMed gnomAD
rs1164131685	2200	Q>E		No	TOPMed gnomAD
rs146680210	2200	Q>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs146680210	2200	Q>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs146680210 COSM1319161 COSM1319162	2200	Q>R	haematopoietic_and_lymphoid_tissue [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
COSM4785391 COSM1440038	2201	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128537151	2201	E>D		No	Ensembl
rs2128537161	2201	E>K		No	Ensembl
rs2128537161	2201	E>Q		No	Ensembl
rs2128537158	2201	E>V		No	Ensembl
rs745498493	2202	P>A		No	ExAC TOPMed gnomAD
rs1774688129	2202	P>H		No	Ensembl
rs1774688129	2202	P>L		No	Ensembl
rs1774688129	2202	P>R		No	Ensembl
rs745498493	2202	P>S		No	ExAC TOPMed gnomAD
rs745498493	2202	P>T		No	ExAC TOPMed gnomAD
rs1774687631	2203	D>E		No	TOPMed
rs556427413	2203	D>H		No	1000Genomes ExAC TOPMed gnomAD
VAR_041458 rs556427413	2203	D>N		No	UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs2128537110	2203	D>V		No	Ensembl
rs771313001	2204	Q>*		No	ExAC TOPMed gnomAD
rs771313001	2204	Q>E		No	ExAC TOPMed gnomAD
rs771313001	2204	Q>K		No	ExAC TOPMed gnomAD
rs144594219	2204	Q>L		No	ESP ExAC TOPMed gnomAD
rs144594219	2204	Q>R		No	ESP ExAC TOPMed gnomAD
rs2128537083	2205	R>*		No	Ensembl
rs145104466	2205	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs145104466	2205	R>K		No	ESP ExAC TOPMed gnomAD
rs2128537068	2205	R>S		No	Ensembl
rs145104466	2205	R>T		No	ESP ExAC TOPMed gnomAD
rs2128537063	2206	P>A		No	Ensembl
rs2128537056	2206	P>L		No	Ensembl
rs2128537056	2206	P>R		No	Ensembl
rs2128537063	2206	P>S		No	Ensembl
rs2128537063	2206	P>T		No	Ensembl
rs149949391	2207	T>A		No	ESP ExAC TOPMed gnomAD
TCGA novel rs2128537038	2207	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
COSM4160146 rs2128537038 COSM4160147	2207	T>S	thyroid [Cosmic]	No	cosmic curated Ensembl
COSM4160146 rs149949391 COSM4160147	2207	T>S	thyroid [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs1051601581	2208	F>C		No	TOPMed gnomAD
rs2128537028	2208	F>L		No	Ensembl
rs2128537019	2209	H>D		No	Ensembl
rs748687432	2209	H>L		No	ExAC TOPMed gnomAD
rs2128537019 COSM4006105 COSM4006106	2209	H>N	urinary_tract [Cosmic]	No	cosmic curated Ensembl
rs748687432	2209	H>P		No	ExAC TOPMed gnomAD
rs538165958	2209	H>Q		No	1000Genomes ExAC TOPMed gnomAD
rs748687432	2209	H>R		No	ExAC TOPMed gnomAD
rs2128537019	2209	H>Y		No	Ensembl
COSM739519 COSM1647885 COSM739518 rs1278629013	2210	R>*	lung Variant assessed as Somatic; HIGH impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
rs1278629013	2210	R>G		No	TOPMed
COSM1440036 COSM1440035 rs148104006	2210	R>I	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs148104006	2210	R>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs148104006	2210	R>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128536986	2211	I>N		No	Ensembl
rs2128536993	2211	I>V		No	Ensembl
rs866580908	2212	Q>*		No	TOPMed gnomAD
rs866580908	2212	Q>E		No	TOPMed gnomAD
rs1774684203	2212	Q>H		No	Ensembl
rs2128536970	2212	Q>L		No	Ensembl
rs2128536970	2212	Q>R		No	Ensembl
VAR_041459 rs75510639	2213	D>E		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs529038	2213	D>H		No	1000Genomes ESP ExAC TOPMed gnomAD
VAR_030655 rs529038	2213	D>N		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2128536949	2213	D>V		No	Ensembl
rs529038	2213	D>Y		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128536938	2214	Q>*		No	Ensembl
rs2128536934	2214	Q>H		No	Ensembl
rs2128536938	2214	Q>K		No	Ensembl
rs1358712826	2215	L>F		No	gnomAD
rs1383744493	2215	L>H		No	TOPMed gnomAD
rs1383744493	2215	L>P		No	TOPMed gnomAD
rs1358712826	2215	L>V		No	gnomAD
COSM4504401 rs2128536920 COSM4504402	2216	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128536920	2216	Q>E		No	Ensembl
rs373160577	2216	Q>H		No	ESP ExAC TOPMed gnomAD
rs2128536912	2216	Q>L		No	Ensembl
rs2128536912	2216	Q>R		No	Ensembl
rs1293220338	2217	L>*		No	gnomAD
rs2128536893	2217	L>F		No	Ensembl
rs993857429	2217	L>I		No	Ensembl
rs1293220338	2217	L>S		No	gnomAD
rs376903822	2218	F>L		No	ESP TOPMed gnomAD
rs2128536887	2218	F>Y		No	Ensembl
rs1351695625	2219	R>K		No	gnomAD
rs1351695625	2219	R>T		No	gnomAD
rs760646608	2220	N>I		No	ExAC TOPMed gnomAD
rs775605839	2220	N>K		No	ExAC gnomAD
rs760646608	2220	N>S		No	ExAC TOPMed gnomAD
rs2128536858	2221	F>I		No	Ensembl
COSM6172046 COSM6172047	2222	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs759025806	2222	F>S		No	ExAC TOPMed gnomAD
rs767110496	2222	F>V		No	ExAC gnomAD
rs759025806	2222	F>Y		No	ExAC TOPMed gnomAD
rs2128536843	2223	L>*		No	Ensembl
rs2128536837	2223	L>F		No	Ensembl
rs1475122880	2224	N>H		No	TOPMed gnomAD
rs777946284	2224	N>I		No	Ensembl
TCGA novel	2224	N>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs777946284	2224	N>T		No	Ensembl
rs2128536824	2225	S>C		No	Ensembl
rs774048022	2225	S>I		No	ExAC TOPMed gnomAD
rs774048022	2225	S>N		No	ExAC TOPMed gnomAD
rs2128536813	2225	S>R		No	Ensembl
rs774048022	2225	S>T		No	ExAC TOPMed gnomAD
rs2128536799	2227	Y>*		No	Ensembl
rs565633598	2227	Y>C		No	1000Genomes ExAC TOPMed gnomAD
rs2128536805	2227	Y>N		No	Ensembl
rs529156	2228	K>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs529156	2228	K>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs529156 VAR_041460	2228	K>Q		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	2228	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs619203 VAR_030656	2229	S>C		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs619203	2229	S>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128536782	2229	S>T		No	Ensembl
rs619203	2229	S>Y		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128536751	2230	R>I		No	Ensembl
COSM3619811 COSM3619810 rs2128536751	2230	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
COSM4844841 rs2128536751 COSM4844840	2230	R>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1341332039	2231	D>E		No	TOPMed gnomAD
rs2128536742	2231	D>H		No	Ensembl
rs2128536742	2231	D>N		No	Ensembl
rs2128536742	2231	D>Y		No	Ensembl
rs1275344272 COSM4844545 COSM4844544	2232	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs2128536717	2232	E>D		No	Ensembl
COSM1440033 COSM4783153 COSM1440034 rs1774677457	2232	E>G	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic TOPMed gnomAD
rs1275344272 RCV001728069	2232	E>K		No	ClinVar dbSNP gnomAD
rs1275344272	2232	E>Q		No	gnomAD
rs1774677457	2232	E>V		No	TOPMed gnomAD
rs748632361	2233	A>E		No	ExAC gnomAD
rs748632361	2233	A>G		No	ExAC gnomAD
rs1385257970	2233	A>P		No	TOPMed gnomAD
rs1385257970	2233	A>S		No	TOPMed gnomAD
rs1385257970	2233	A>T		No	TOPMed gnomAD
rs748632361	2233	A>V		No	ExAC gnomAD
rs1053611030	2234	N>D		No	TOPMed gnomAD
COSM450397 COSM1224150 COSM1224151 rs2128536688 COSM450396 COSM4814528	2234	N>K	Variant assessed as Somatic; MODERATE impact. large_intestine breast [NCI-TCGA, Cosmic]	No	cosmic curated Ensembl NCI-TCGA Cosmic
rs2128536699	2234	N>T		No	Ensembl
rs1053611030	2234	N>Y		No	TOPMed gnomAD
rs781709699	2235	N>I		No	ExAC TOPMed gnomAD
rs2128536673	2235	N>K		No	Ensembl
rs781709699	2235	N>S		No	ExAC TOPMed gnomAD
rs781709699	2235	N>T		No	ExAC TOPMed gnomAD
rs2128536684	2235	N>Y		No	Ensembl
rs2128536671	2236	S>C		No	Ensembl
rs368902897	2236	S>N		No	ESP ExAC TOPMed gnomAD
rs746997621	2236	S>R		No	ExAC TOPMed gnomAD
rs368902897	2236	S>T		No	ESP ExAC TOPMed gnomAD
rs2128536656	2237	G>*		No	Ensembl
rs564889461	2237	G>A		No	1000Genomes ExAC gnomAD
rs564889461 COSM3619809 COSM3619808	2237	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA gnomAD
rs2128536656	2237	G>R		No	Ensembl
rs2128536646	2238	V>A		No	Ensembl
rs2128536646	2238	V>D		No	Ensembl
rs2128536651	2238	V>L		No	Ensembl
rs2128536632	2239	I>K		No	Ensembl
rs2128536636	2239	I>L		No	Ensembl
rs2128536623	2239	I>M		No	Ensembl
rs2128536636	2239	I>V		No	Ensembl
VAR_030657 rs210968	2240	N>K		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
COSM3619807 rs2128536614 COSM3619806	2241	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128536614	2241	E>Q		No	Ensembl
rs1774675235 COSM3619805 COSM3619804	2242	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs1774675235	2242	S>G		No	TOPMed
rs1310399838	2242	S>R		No	gnomAD
rs750686582	2242	S>T		No	ExAC TOPMed gnomAD
rs2128536594	2243	F>L		No	Ensembl
rs2128536601	2243	F>Y		No	Ensembl
rs1466970576	2244	E>D		No	Ensembl
rs1774674564	2244	E>Q		No	TOPMed gnomAD
rs148710046	2245	G>A		No	ESP ExAC gnomAD
rs148710046	2245	G>D		No	ESP ExAC gnomAD
rs142264513	2245	G>S		No	1000Genomes ESP TOPMed gnomAD
TCGA novel rs148710046	2245	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA ESP ExAC gnomAD
rs1582513438	2246	E>D		No	Ensembl
rs1412107750	2246	E>K		No	TOPMed gnomAD
rs1412107750	2246	E>Q		No	TOPMed gnomAD
rs2128521408	2247	D>E		No	Ensembl
rs2128521409	2247	D>G		No	Ensembl
rs2128521409	2247	D>V		No	Ensembl
COSM1072505 COSM4866554	2247	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128521397	2248	G>A		No	Ensembl
rs2128521397	2248	G>D		No	Ensembl
rs2128521404	2248	G>R		No	Ensembl
rs2128521404	2248	G>S		No	Ensembl
rs2128521397	2248	G>V		No	Ensembl
rs2128521382	2249	D>E		No	Ensembl
rs369184938	2249	D>H		No	ESP ExAC TOPMed gnomAD
COSM1072502 rs369184938 COSM1072500 COSM4868878	2249	D>N	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs2128521387	2249	D>V		No	Ensembl
rs369184938	2249	D>Y		No	ESP ExAC TOPMed gnomAD
rs1304088293	2250	V>A		No	TOPMed gnomAD
rs1304088293	2250	V>E		No	TOPMed gnomAD
rs1304088293	2250	V>G		No	TOPMed gnomAD
rs2128521376	2250	V>L		No	Ensembl
rs2128521376	2250	V>M		No	Ensembl
rs2128521367	2251	I>F		No	Ensembl
rs2128521367	2251	I>V		No	Ensembl
rs1200820127	2252	C>*		No	gnomAD
rs779954823	2252	C>F		No	ExAC TOPMed gnomAD
rs779954823	2252	C>S		No	ExAC TOPMed gnomAD
rs2128521361	2252	C>S		No	Ensembl
rs1200820127	2252	C>W		No	gnomAD
rs779954823	2252	C>Y		No	ExAC TOPMed gnomAD
rs2128521346	2253	L>*		No	Ensembl
rs2128521342	2254	N>D		No	Ensembl
rs772230848	2254	N>I		No	ExAC gnomAD
rs2128521336	2254	N>K		No	Ensembl
rs772230848	2254	N>S		No	ExAC gnomAD
rs2128521342	2254	N>Y		No	Ensembl
rs538891848	2255	S>*		No	1000Genomes ExAC TOPMed gnomAD
rs538891848	2255	S>L		No	1000Genomes ExAC TOPMed gnomAD
rs547573917	2255	S>P		No	1000Genomes ExAC TOPMed gnomAD
rs2128521319	2256	D>E		No	Ensembl
rs2128521324	2256	D>H		No	Ensembl
rs2128521324	2256	D>N		No	Ensembl
rs755967485	2256	D>V		No	ExAC gnomAD
rs2128521324	2256	D>Y		No	Ensembl
rs754820794	2257	D>E		No	ExAC TOPMed gnomAD
rs375010729	2257	D>G		No	ESP ExAC TOPMed gnomAD
rs144393305	2257	D>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs144393305	2257	D>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs375010729	2257	D>V		No	ESP ExAC TOPMed gnomAD
rs144393305	2257	D>Y		No	1000Genomes ESP ExAC TOPMed gnomAD
rs954647191	2258	I>L		No	TOPMed gnomAD
rs751557733	2258	I>T		No	ExAC TOPMed gnomAD
rs954647191	2258	I>V		No	TOPMed gnomAD
rs2128521294	2259	M>I		No	Ensembl
rs2128521297	2259	M>K		No	Ensembl
rs1195270053	2260	P>A		No	Ensembl
rs2128521281	2260	P>L		No	Ensembl
rs2128521281	2260	P>Q		No	Ensembl
rs2128521281	2260	P>R		No	Ensembl
rs1195270053 COSM1072499 COSM1072497 COSM4139066	2260	P>S	ovary Variant assessed as Somatic; MODERATE impact. endometrium [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic Ensembl
rs1195270053	2260	P>T		No	Ensembl
rs552282840	2261	V>D		No	1000Genomes
rs371313465	2261	V>F		No	ESP ExAC TOPMed gnomAD
rs371313465	2261	V>I		No	ESP ExAC TOPMed gnomAD
rs371313465	2261	V>L		No	ESP ExAC TOPMed gnomAD
rs2128521265	2262	A>G		No	Ensembl
rs2128521268	2262	A>P		No	Ensembl
rs2128521268	2262	A>S		No	Ensembl
rs2128521265	2262	A>V		No	Ensembl
rs2128521250	2263	L>*		No	Ensembl
rs2128521253	2263	L>I		No	Ensembl
COSM3619802 COSM3619803 rs761470868	2264	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC gnomAD NCI-TCGA Cosmic NCI-TCGA
rs764807682	2264	M>K		No	ExAC TOPMed
rs750075965	2264	M>L		No	ExAC gnomAD
rs764807682	2264	M>T		No	ExAC TOPMed
rs201673653	2265	E>*		No	ExAC TOPMed gnomAD
rs149630222	2265	E>D		No	ESP ExAC TOPMed gnomAD
rs201673653	2265	E>K		No	ExAC TOPMed gnomAD
rs201673653	2265	E>Q		No	ExAC TOPMed gnomAD
rs781588795	2266	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2128521226	2266	T>S		No	Ensembl
rs2128521216	2267	K>M		No	Ensembl
rs138446817	2267	K>N		No	ESP ExAC TOPMed gnomAD
rs2128521216	2267	K>R		No	Ensembl
rs1187748126	2268	N>I		No	gnomAD
rs746010215	2268	N>K		No	ExAC gnomAD
rs1187748126 COSM3619800 COSM3619801	2268	N>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs2128521214	2268	N>Y		No	Ensembl
rs202153378 COSM4166710 COSM4166711	2269	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs202153378	2269	R>G		No	ExAC TOPMed gnomAD
rs771217753	2269	R>L		No	ExAC TOPMed gnomAD
rs771217753	2269	R>P		No	ExAC TOPMed gnomAD
rs771217753	2269	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
COSM371982	2270	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1355743227	2270	E>D		No	gnomAD
rs2128521196	2270	E>G		No	Ensembl
COSM249317 COSM249318 rs1302341778	2270	E>K	kidney [Cosmic]	No	cosmic curated TOPMed
rs1302341778	2270	E>Q		No	TOPMed
rs2128521196	2270	E>V		No	Ensembl
rs749542060	2271	G>A		No	ExAC TOPMed gnomAD
COSM229499 rs749542060 COSM229500	2271	G>E	skin [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs1773608412 COSM3920635 COSM3920636	2271	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	TOPMed NCI-TCGA Cosmic
rs749542060	2271	G>V		No	ExAC TOPMed gnomAD
rs1773608412	2271	G>W		No	TOPMed
rs2128521170	2272	L>*		No	Ensembl
rs2128521168	2272	L>F		No	Ensembl
rs1747701150	2272	L>I		No	TOPMed
rs2128521170	2272	L>S		No	Ensembl
rs1747701150	2272	L>V		No	TOPMed
rs2128521166	2273	N>D		No	Ensembl
rs1773607883	2273	N>I		No	Ensembl
rs1773607883	2273	N>S		No	Ensembl
rs754854156	2274	Y>*		No	ExAC gnomAD
rs780819532	2274	Y>C		No	ExAC gnomAD
rs1773607698	2274	Y>H		No	TOPMed
rs1773607698	2274	Y>N		No	TOPMed
rs2128521155	2275	M>I		No	Ensembl
rs751439620	2275	M>K		No	ExAC gnomAD
TCGA novel	2275	M>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs751439620	2275	M>T		No	ExAC gnomAD
TCGA novel rs1773606797	2276	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1773606797	2276	V>L		No	TOPMed
rs1406518415	2277	L>F		No	TOPMed gnomAD
rs2128521144	2277	L>H		No	Ensembl
rs1406518415	2277	L>I		No	TOPMed gnomAD
rs1406518415	2277	L>V		No	TOPMed gnomAD
rs958426252	2278	A>D		No	Ensembl
rs1297293945	2278	A>P		No	gnomAD
rs1297293945	2278	A>S		No	gnomAD
rs1297293945	2278	A>T		No	gnomAD
rs374450773	2279	T>A		No	ESP TOPMed gnomAD
rs183984056	2279	T>I		No	1000Genomes ExAC TOPMed gnomAD
rs374450773	2279	T>P		No	ESP TOPMed gnomAD
rs183984056	2279	T>R		No	1000Genomes ExAC TOPMed gnomAD
rs374450773	2279	T>S		No	ESP TOPMed gnomAD
rs1319948197	2280	E>*		No	gnomAD
rs2128521103	2280	E>D		No	Ensembl
rs1319948197	2280	E>K		No	gnomAD
rs1319948197	2280	E>Q		No	gnomAD
rs2128521104	2280	E>V		No	Ensembl
rs2128521092	2281	C>*		No	Ensembl
rs758340327	2281	C>S		No	ExAC gnomAD
rs2128521092	2281	C>W		No	Ensembl
rs758340327	2281	C>Y		No	ExAC gnomAD
rs41291918	2282	G>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128521091	2282	G>C		No	Ensembl
rs41291918	2282	G>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128521091	2282	G>R		No	Ensembl
rs2128521091	2282	G>S		No	Ensembl
rs41291918	2282	G>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128521082	2283	Q>*		No	Ensembl
rs2128521082	2283	Q>E		No	Ensembl
rs1299949449	2283	Q>H		No	gnomAD
rs2128521082	2283	Q>K		No	Ensembl
rs1164075306	2283	Q>R		No	gnomAD
rs764751833	2284	G>A		No	ExAC TOPMed gnomAD
rs2128521066	2284	G>C		No	Ensembl
COSM284671 COSM5438007 rs764751833 COSM284672	2284	G>D	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs2128521066	2284	G>R		No	Ensembl
rs2128521066	2284	G>S		No	Ensembl
rs764751833	2284	G>V		No	ExAC TOPMed gnomAD
rs1442895655	2285	E>*		No	gnomAD
rs2128521050	2285	E>D		No	Ensembl
rs1442895655	2285	E>K		No	gnomAD
rs1442895655	2285	E>Q		No	gnomAD
rs2128521046	2286	E>K		No	Ensembl
rs2128521046	2286	E>Q		No	Ensembl
rs2128521038	2286	E>V		No	Ensembl
rs2128521036	2287	K>R		No	Ensembl
COSM1264502	2287	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1306014510	2288	S>C		No	TOPMed gnomAD
rs1306014510	2288	S>F		No	TOPMed gnomAD
rs1167721609	2288	S>P		No	gnomAD
rs1167721609	2288	S>T		No	gnomAD
rs1306014510	2288	S>Y		No	TOPMed gnomAD
rs2128521026	2289	E>*		No	Ensembl
rs2128521014	2289	E>D		No	Ensembl
rs2128521022	2289	E>G		No	Ensembl
rs2128521026	2289	E>K		No	Ensembl
rs2128521026	2289	E>Q		No	Ensembl
rs2128521022	2289	E>V		No	Ensembl
rs200558565	2290	G>A		No	TOPMed gnomAD
rs200558565	2290	G>D		No	TOPMed gnomAD
rs200558565	2290	G>V		No	TOPMed gnomAD
rs2128521000	2291	P>L		No	Ensembl
rs2128521000	2291	P>R		No	Ensembl
rs1291536074	2292	L>I		No	TOPMed gnomAD
rs1291536074	2292	L>V		No	TOPMed gnomAD
rs2128520982	2293	G>A		No	Ensembl
rs1664453826	2293	G>C		No	Ensembl
rs2128520982	2293	G>D		No	Ensembl
rs1664453826	2293	G>R		No	Ensembl
rs1664453826	2293	G>S		No	Ensembl
rs2128520982	2293	G>V		No	Ensembl
rs2128520969	2294	S>C		No	Ensembl
COSM4401922 COSM4401923 rs2128520969	2294	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2128520974	2294	S>T		No	Ensembl
rs1773601729	2295	Q>*		No	TOPMed
rs1773601729	2295	Q>E		No	TOPMed
COSM3619796 COSM3619797 rs2128520960	2295	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA Cosmic
rs2128520949	2296	E>D		No	Ensembl
rs2128520951	2296	E>G		No	Ensembl
rs761155034 COSM739520 COSM739521 COSM1647886	2296	E>K	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs761155034	2296	E>Q		No	ExAC gnomAD
rs2128520951	2296	E>V		No	Ensembl
rs2128520942	2297	S>C		No	Ensembl
rs2128520942	2297	S>F		No	Ensembl
rs2128520946	2297	S>T		No	Ensembl
rs2128520942	2297	S>Y		No	Ensembl
rs543882573	2298	E>D		No	ExAC TOPMed gnomAD
COSM3619795 COSM3619794 rs1451070985	2298	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs1451070985	2298	E>Q		No	gnomAD
rs1268176818	2298	E>V		No	gnomAD
rs952691474	2299	S>A		No	Ensembl
rs2128520924	2299	S>C		No	Ensembl
rs2128520924	2299	S>F		No	Ensembl
rs952691474	2299	S>P		No	Ensembl
rs952691474	2299	S>T		No	Ensembl
rs1773599439	2300	C>*		No	Ensembl
rs1162487585	2300	C>F		No	gnomAD
rs1267697295	2300	C>R		No	Ensembl
rs1162487585	2300	C>S		No	gnomAD
rs1773599439	2300	C>W		No	Ensembl
rs1162487585	2300	C>Y		No	gnomAD
rs2128520903	2301	G>A		No	Ensembl
rs2128520903 TCGA novel	2301	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128520903	2301	G>V		No	Ensembl
rs1773599085	2302	L>M		No	Ensembl
rs2128520896	2302	L>P		No	Ensembl
rs1773599085	2302	L>V		No	Ensembl
rs2128520887	2303	R>K		No	Ensembl
rs2128520887	2303	R>M		No	Ensembl
rs2128520887	2303	R>T		No	Ensembl
rs2128520883	2304	K>*		No	Ensembl
rs2128520883	2304	K>E		No	Ensembl
rs2128520877	2304	K>N		No	Ensembl
rs141670885	2305	E>*		No	ESP ExAC TOPMed gnomAD
rs2128520866	2305	E>D		No	Ensembl
rs1773598163	2305	E>G		No	TOPMed
rs141670885	2305	E>K		No	ESP ExAC TOPMed gnomAD
rs141670885	2305	E>Q		No	ESP ExAC TOPMed gnomAD
rs1773597884	2306	E>*		No	TOPMed
rs2128520853	2306	E>D		No	Ensembl
rs760133473	2306	E>G		No	ExAC gnomAD
rs1773597884	2306	E>K		No	TOPMed
rs1773597884	2306	E>Q		No	TOPMed
rs2128520849	2307	K>*		No	Ensembl
rs2128520844	2307	K>M		No	Ensembl
TCGA novel rs2128520836	2307	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2128520844	2307	K>R		No	Ensembl
rs2128520828	2308	E>D		No	Ensembl
COSM3920634 rs2128520834 COSM3920633	2308	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
COSM483316 COSM1645908	2308	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128520831	2308	E>V		No	Ensembl
rs1271530026	2309	P>A		No	gnomAD
rs199825447	2309	P>L		No	Ensembl
rs199825447	2309	P>R		No	Ensembl
rs1271530026	2309	P>S		No	gnomAD
rs1271530026	2309	P>T		No	gnomAD
rs2128520819	2310	H>D		No	Ensembl
rs1409586765	2310	H>L		No	gnomAD
rs1409586765 COSM4930667 COSM4930666	2310	H>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic gnomAD
rs2128520811	2310	H>Q		No	Ensembl
rs1409586765	2310	H>R		No	gnomAD
rs1773596227	2311	A>G		No	Ensembl
rs1773596532	2311	A>P		No	Ensembl
rs1773596532	2311	A>S		No	Ensembl
rs1773596532	2311	A>T		No	Ensembl
rs1773596227	2311	A>V		No	Ensembl
rs2128520788	2312	D>E		No	Ensembl
rs774522126	2312	D>G		No	ExAC gnomAD
rs2128520793	2312	D>H		No	Ensembl
rs2128520793	2312	D>N		No	Ensembl
rs774522126	2312	D>V		No	ExAC gnomAD
rs2128520793	2312	D>Y		No	Ensembl
rs2128520775	2314	D>E		No	Ensembl
rs771164515	2314	D>H		No	ExAC gnomAD
rs771164515	2314	D>N		No	ExAC gnomAD
rs2128520776	2314	D>V		No	Ensembl
rs771164515	2314	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2128520772	2315	F>I		No	Ensembl
rs2128520772	2315	F>L		No	Ensembl
rs1773595131	2315	F>L		No	TOPMed gnomAD
rs199971914	2315	F>S		No	1000Genomes ExAC TOPMed gnomAD
rs199971914	2315	F>Y		No	1000Genomes ExAC TOPMed gnomAD
rs2128520750	2316	C>*		No	Ensembl
rs773542381	2316	C>F		No	ExAC gnomAD
rs773542381	2316	C>S		No	ExAC gnomAD
rs2128520762	2316	C>S		No	Ensembl
rs2128520750	2316	C>W		No	Ensembl
rs773542381	2316	C>Y		No	ExAC gnomAD
rs2128520741	2317	Q>*		No	Ensembl
rs2128520741	2317	Q>E		No	Ensembl
rs2128520740	2317	Q>H		No	Ensembl
rs2128520741	2317	Q>K		No	Ensembl
rs768332561	2318	E>*		No	ExAC TOPMed gnomAD
rs1307353332	2318	E>G		No	gnomAD
rs768332561	2318	E>K		No	ExAC TOPMed gnomAD
rs768332561	2318	E>Q		No	ExAC TOPMed gnomAD
rs2128520731	2319	K>E		No	Ensembl
rs1430357922	2319	K>N		No	Ensembl
rs746755507	2320	Q>*		No	ExAC TOPMed
rs779731708	2320	Q>H		No	ExAC TOPMed gnomAD
rs1773593720	2320	Q>R		No	TOPMed
rs756068637	2320	Q>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1773593324	2321	V>A		No	gnomAD
rs1773593324	2321	V>E		No	gnomAD
rs1773593324	2321	V>G		No	gnomAD
rs2128520707	2321	V>L		No	Ensembl
rs2128520707	2321	V>M		No	Ensembl
rs559726522	2322	A>P		No	1000Genomes ExAC gnomAD
rs559726522	2322	A>S		No	1000Genomes ExAC gnomAD
COSM4403686 COSM4403687 rs559726522	2322	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA gnomAD
rs2128520680	2323	Y>*		No	Ensembl
rs2128520687	2323	Y>D		No	Ensembl
rs1477810013	2323	Y>F		No	gnomAD
rs1773592818	2324	C>F		No	Ensembl
rs2128520676	2324	C>S		No	Ensembl
rs1773592818	2324	C>S		No	Ensembl
rs1459307793	2324	C>W		No	TOPMed
rs1773592818	2324	C>Y		No	Ensembl
rs2128520668	2325	P>A		No	Ensembl
rs2128520664	2325	P>L		No	Ensembl
rs2128520664	2325	P>R		No	Ensembl
rs2128520668	2325	P>S		No	Ensembl
rs1430294646	2326	S>C		No	gnomAD
COSM3828887 rs1430294646 COSM3828888	2326	S>F	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs2128520660	2326	S>T		No	Ensembl
rs1430294646	2326	S>Y		No	gnomAD
rs1039978685	2327	G>A		No	TOPMed gnomAD
rs372807954	2327	G>C		No	ESP ExAC TOPMed gnomAD
rs1039978685	2327	G>D		No	TOPMed gnomAD
rs372807954	2327	G>R		No	ESP ExAC TOPMed gnomAD
rs372807954	2327	G>S		No	ESP ExAC TOPMed gnomAD
rs1039978685	2327	G>V		No	TOPMed gnomAD
rs35932630	2328	K>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1439867576	2328	K>N		No	TOPMed gnomAD
VAR_049713 rs35932630 RCV000963870	2328	K>R		No	ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs143434059	2329	P>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1773591322	2329	P>H		No	TOPMed
rs1773591322	2329	P>L		No	TOPMed
rs1773591322	2329	P>R		No	TOPMed
rs143434059	2329	P>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs143434059	2329	P>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2128520612	2330	E>D		No	Ensembl
rs2128520617	2330	E>G		No	Ensembl
rs2128520620	2330	E>K		No	Ensembl
rs2128520620	2330	E>Q		No	Ensembl
rs2128520617	2330	E>V		No	Ensembl
rs2128520603	2331	G>A		No	Ensembl
rs2128520609	2331	G>C		No	Ensembl
rs2128520603	2331	G>D		No	Ensembl
rs2128520609	2331	G>R		No	Ensembl
rs2128520603	2331	G>V		No	Ensembl
rs2128520598	2332	L>M		No	Ensembl
rs2128520596	2332	L>P		No	Ensembl
rs2128520596	2332	L>Q		No	Ensembl
rs2128520598	2332	L>V		No	Ensembl
rs2128520584	2333	N>K		No	Ensembl
rs2128520591	2333	N>S		No	Ensembl
rs2128520580	2334	Y>*		No	Ensembl
rs755725202	2334	Y>C		No	ExAC gnomAD
rs755725202	2334	Y>F		No	ExAC gnomAD
rs2128520582	2334	Y>H		No	Ensembl
rs2128520582	2334	Y>N		No	Ensembl
rs2128520571	2335	A>D		No	Ensembl
rs2128520571	2335	A>G		No	Ensembl
rs2128520576	2335	A>P		No	Ensembl
rs2128520576	2335	A>T		No	Ensembl
rs2128520571	2335	A>V		No	Ensembl
rs565221390	2336	C>*		No	1000Genomes ExAC TOPMed gnomAD
rs2128520562	2336	C>F		No	Ensembl
rs2128520566	2336	C>R		No	Ensembl
rs2128520562	2336	C>S		No	Ensembl
rs565221390	2336	C>W		No	1000Genomes ExAC TOPMed gnomAD
rs2128520552	2337	L>F		No	Ensembl
rs2128520547	2337	L>H		No	Ensembl
rs2128520547	2337	L>P		No	Ensembl
rs2128520552	2337	L>V		No	Ensembl
rs1773589751	2338	T>A		No	Ensembl
rs1773589751	2338	T>S		No	Ensembl
rs2128520531	2338	T>S		No	Ensembl
rs2128520524	2339	H>D		No	Ensembl
rs200900115	2339	H>L		No	ExAC gnomAD
rs2128520524	2339	H>N		No	Ensembl
rs200900115	2339	H>P		No	ExAC gnomAD
rs2128520512	2339	H>Q		No	Ensembl
rs2128520524	2339	H>Y		No	Ensembl
rs2128520502	2340	S>N		No	Ensembl
rs760078455	2340	S>R		No	ExAC gnomAD
rs2128520502	2340	S>T		No	Ensembl
rs2128520493 TCGA novel	2341	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1442866318	2341	G>R		No	TOPMed gnomAD
rs2128520482	2342	Y>*		No	Ensembl
COSM267349	2342	Y>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2128520487	2342	Y>N		No	Ensembl
rs2128520474	2343	G>A		No	Ensembl
rs2128520474	2343	G>E		No	Ensembl
rs2128520478	2343	G>R		No	Ensembl
rs2128520474	2343	G>V		No	Ensembl
rs1266344795	2344	D>E		No	TOPMed
rs766555708	2344	D>H		No	ExAC TOPMed gnomAD
rs766555708	2344	D>N		No	ExAC TOPMed gnomAD
rs766555708	2344	D>Y		No	ExAC TOPMed gnomAD
rs371063080	2345	G>A		No	ESP ExAC TOPMed gnomAD
rs371063080	2345	G>E		No	ESP ExAC TOPMed gnomAD
rs2128520466	2345	G>R		No	Ensembl
rs371063080	2345	G>V		No	ESP ExAC TOPMed gnomAD
rs2128520458	2346	S>A		No	Ensembl
rs1178874356	2346	S>C		No	TOPMed gnomAD
rs2128520458	2346	S>P		No	Ensembl
rs2128520458	2346	S>T		No	Ensembl
rs2128520441	2347	D>E		No	Ensembl
rs2128520449	2347	D>H		No	Ensembl
rs2128520449	2347	D>N		No	Ensembl
rs2128520445	2347	D>V		No	Ensembl
rs2128520438	2348	D>K		No	Ensembl
rs2128520435 COSM291293	2348	D>Y	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl

1 associated diseases with P08922

Without disease ID

19 regional properties for P08922

Type	Name	Position	InterPro Accession
repeat	LDLR class B repeat	359 - 399	IPR000033-1
repeat	LDLR class B repeat	697 - 736	IPR000033-2
repeat	LDLR class B repeat	738 - 780	IPR000033-3
repeat	LDLR class B repeat	781 - 819	IPR000033-4
domain	Protein kinase domain	1945 - 2222	IPR000719
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	1948 - 2215	IPR001245
conserved_site	Tyrosine-protein kinase, receptor class II, conserved site	2108 - 2116	IPR002011
domain	Fibronectin type III	99 - 196	IPR003961-1
domain	Fibronectin type III	195 - 285	IPR003961-2
domain	Fibronectin type III	557 - 671	IPR003961-3
domain	Fibronectin type III	948 - 1028	IPR003961-4
domain	Fibronectin type III	1041 - 1150	IPR003961-5
domain	Fibronectin type III	1469 - 1539	IPR003961-6
domain	Fibronectin type III	1557 - 1656	IPR003961-7
domain	Fibronectin type III	1658 - 1751	IPR003961-8
domain	Fibronectin type III	1753 - 1842	IPR003961-9
active_site	Tyrosine-protein kinase, active site	2075 - 2087	IPR008266
binding_site	Protein kinase, ATP binding site	1951 - 1980	IPR017441
domain	Tyrosine-protein kinase, catalytic domain	1945 - 2215	IPR020635

Functions

		Description
EC Number	2.7.10.1	Protein-tyrosine kinases
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

4 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein phosphatase binding	Binding to a protein phosphatase.
protein tyrosine kinase activity	Catalysis of the reaction
transmembrane receptor protein tyrosine kinase activity	Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction

8 GO annotations of biological process

Name	Definition
cell differentiation	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
columnar/cuboidal epithelial cell development	The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of cell growth	Any process that modulates the frequency, rate, extent or direction of cell growth.
regulation of ERK1 and ERK2 cascade	Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
regulation of TOR signaling	Any process that modulates the frequency, rate or extent of TOR signaling.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
transmembrane receptor protein tyrosine kinase signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

53 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q769I5	MET	Hepatocyte growth factor receptor	Bos taurus (Bovine)	PR
A0M8S8	MET	Hepatocyte growth factor receptor	Felis catus (Cat) (Felis silvestris catus)	PR
P14616	INSRR	Insulin receptor-related protein	Homo sapiens (Human)	SS
Q9UM73	ALK	ALK tyrosine kinase receptor	Homo sapiens (Human)	EV
Q06418	TYRO3	Tyrosine-protein kinase receptor TYRO3	Homo sapiens (Human)	SS
P08069	IGF1R	Insulin-like growth factor 1 receptor	Homo sapiens (Human)	EV
Q12866	MERTK	Tyrosine-protein kinase Mer	Homo sapiens (Human)	EV
Q01974	ROR2	Tyrosine-protein kinase transmembrane receptor ROR2	Homo sapiens (Human)	EV
P07949	RET	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (Human)	EV
O15146	MUSK	Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (Human)	EV
Q01973	ROR1	Inactive tyrosine-protein kinase transmembrane receptor ROR1	Homo sapiens (Human)	PR
Q16832	DDR2	Discoidin domain-containing receptor 2	Homo sapiens (Human)	SS
Q08345	DDR1	Epithelial discoidin domain-containing receptor 1	Homo sapiens (Human)	EV
Q16620	NTRK2	BDNF/NT-3 growth factors receptor	Homo sapiens (Human)	EV
P04629	NTRK1	High affinity nerve growth factor receptor	Homo sapiens (Human)	EV
Q16288	NTRK3	NT-3 growth factor receptor	Homo sapiens (Human)	SS
P35916	FLT4	Vascular endothelial growth factor receptor 3	Homo sapiens (Human)	SS
P17948	FLT1	Vascular endothelial growth factor receptor 1	Homo sapiens (Human)	SS
P35968	KDR	Vascular endothelial growth factor receptor 2	Homo sapiens (Human)	EV
P29317	EPHA2	Ephrin type-A receptor 2	Homo sapiens (Human)	SS
P21709	EPHA1	Ephrin type-A receptor 1	Homo sapiens (Human)	SS
P54760	EPHB4	Ephrin type-B receptor 4	Homo sapiens (Human)	SS
P29376	LTK	Leukocyte tyrosine kinase receptor	Homo sapiens (Human)	SS
P06213	INSR	Insulin receptor	Homo sapiens (Human)	EV
P11362	FGFR1	Fibroblast growth factor receptor 1	Homo sapiens (Human)	EV
P21802	FGFR2	Fibroblast growth factor receptor 2	Homo sapiens (Human)	EV
P22455	FGFR4	Fibroblast growth factor receptor 4	Homo sapiens (Human)	SS
P22607	FGFR3	Fibroblast growth factor receptor 3	Homo sapiens (Human)	EV
Q04912	MST1R	Macrophage-stimulating protein receptor	Homo sapiens (Human)	EV
P30530	AXL	Tyrosine-protein kinase receptor UFO	Homo sapiens (Human)	PR
P08581	MET	Hepatocyte growth factor receptor	Homo sapiens (Human)	EV
P04626	ERBB2	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (Human)	SS
Q15303	ERBB4	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (Human)	SS
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (Human)	SS
P00533	EGFR	Epidermal growth factor receptor	Homo sapiens (Human)	EV
P34925	RYK	Tyrosine-protein kinase RYK	Homo sapiens (Human)	PR
Q02763	TEK	Angiopoietin-1 receptor	Homo sapiens (Human)	SS
P35590	TIE1	Tyrosine-protein kinase receptor Tie-1	Homo sapiens (Human)	PR
P10721	KIT	Mast/stem cell growth factor receptor Kit	Homo sapiens (Human)	EV
P09619	PDGFRB	Platelet-derived growth factor receptor beta	Homo sapiens (Human)	EV
P07333	CSF1R	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (Human)	SS
P16234	PDGFRA	Platelet-derived growth factor receptor alpha	Homo sapiens (Human)	EV
P36888	FLT3	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (Human)	EV
Q9WTL4	Insrr	Insulin receptor-related protein	Mus musculus (Mouse)	SS
Q62190	Mst1r	Macrophage-stimulating protein receptor	Mus musculus (Mouse)	SS
P97793	Alk	ALK tyrosine kinase receptor	Mus musculus (Mouse)	SS
P16056	Met	Hepatocyte growth factor receptor	Mus musculus (Mouse)	PR
P97523	Met	Hepatocyte growth factor receptor	Rattus norvegicus (Rat)	PR
Q64716	Insrr	Insulin receptor-related protein	Rattus norvegicus (Rat)	SS
H2KZU7	svh-2	Tyrosine-protein kinase receptor svh-2	Caenorhabditis elegans	SS
Q8I7I5	rol-3	Protein roller-3	Caenorhabditis elegans	PR
F1QVU0	ltk	Tyrosine-protein kinase receptor	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
F8W3R9	alk	ALK tyrosine kinase receptor	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MKNIYCLIPK	LVNFATLGCL	WISVVQCTVL	NSCLKSCVTN	LGQQLDLGTP	HNLSEPCIQG
70	80	90	100	110	120
CHFWNSVDQK	NCALKCRESC	EVGCSSAEGA	YEEEVLENAD	LPTAPFASSI	GSHNMTLRWK
130	140	150	160	170	180
SANFSGVKYI	IQWKYAQLLG	SWTYTKTVSR	PSYVVKPLHP	FTEYIFRVVW	IFTAQLQLYS
190	200	210	220	230	240
PPSPSYRTHP	HGVPETAPLI	RNIESSSPDT	VEVSWDPPQF	PGGPILGYNL	RLISKNQKLD
250	260	270	280	290	300
AGTQRTSFQF	YSTLPNTIYR	FSIAAVNEVG	EGPEAESSIT	TSSSAVQQEE	QWLFLSRKTS
310	320	330	340	350	360
LRKRSLKHLV	DEAHCLRLDA	IYHNITGISV	DVHQQIVYFS	EGTLIWAKKA	ANMSDVSDLR
370	380	390	400	410	420
IFYRGSGLIS	SISIDWLYQR	MYFIMDELVC	VCDLENCSNI	EEITPPSISA	PQKIVADSYN
430	440	450	460	470	480
GYVFYLLRDG	IYRADLPVPS	GRCAEAVRIV	ESCTLKDFAI	KPQAKRIIYF	NDTAQVFMST
490	500	510	520	530	540
FLDGSASHLI	LPRIPFADVK	SFACENNDFL	VTDGKVIFQQ	DALSFNEFIV	GCDLSHIEEF
550	560	570	580	590	600
GFGNLVIFGS	SSQLHPLPGR	PQELSVLFGS	HQALVQWKPP	ALAIGANVIL	ISDIIELFEL
610	620	630	640	650	660
GPSAWQNWTY	EVKVSTQDPP	EVTHIFLNIS	GTMLNVPELQ	SAMKYKVSVR	ASSPKRPGPW
670	680	690	700	710	720
SEPSVGTTLV	PASEPPFIMA	VKEDGLWSKP	LNSFGPGEFL	SSDIGNVSDM	DWYNNSLYYS
730	740	750	760	770	780
DTKGDVFVWL	LNGTDISENY	HLPSIAGAGA	LAFEWLGHFL	YWAGKTYVIQ	RQSVLTGHTD
790	800	810	820	830	840
IVTHVKLLVN	DMVVDSVGGY	LYWTTLYSVE	STRLNGESSL	VLQTQPWFSG	KKVIALTLDL
850	860	870	880	890	900
SDGLLYWLVQ	DSQCIHLYTA	VLRGQSTGDT	TITEFAAWST	SEISQNALMY	YSGRLFWING
910	920	930	940	950	960
FRIITTQEIG	QKTSVSVLEP	ARFNQFTIIQ	TSLKPLPGNF	SFTPKVIPDS	VQESSFRIEG
970	980	990	1000	1010	1020
NASSFQILWN	GPPAVDWGVV	FYSVEFSAHS	KFLASEQHSL	PVFTVEGLEP	YALFNLSVTP
1030	1040	1050	1060	1070	1080
YTYWGKGPKT	SLSLRAPETV	PSAPENPRIF	ILPSGKCCNK	NEVVVEFRWN	KPKHENGVLT
1090	1100	1110	1120	1130	1140
KFEIFYNISN	QSITNKTCED	WIAVNVTPSV	MSFQLEGMSP	RCFIAFQVRA	FTSKGPGPYA
1150	1160	1170	1180	1190	1200
DVVKSTTSEI	NPFPHLITLL	GNKIVFLDMD	QNQVVWTFSA	ERVISAVCYT	ADNEMGYYAE
1210	1220	1230	1240	1250	1260
GDSLFLLHLH	NRSSSELFQD	SLVFDITVIT	IDWISRHLYF	ALKESQNGMQ	VFDVDLEHKV
1270	1280	1290	1300	1310	1320
KYPREVKIHN	RNSTIISFSV	YPLLSRLYWT	EVSNFGYQMF	YYSIISHTLH	RILQPTATNQ
1330	1340	1350	1360	1370	1380
QNKRNQCSCN	VTEFELSGAM	AIDTSNLEKP	LIYFAKAQEI	WAMDLEGCQC	WRVITVPAML
1390	1400	1410	1420	1430	1440
AGKTLVSLTV	DGDLIYWIIT	AKDSTQIYQA	KKGNGAIVSQ	VKALRSRHIL	AYSSVMQPFP
1450	1460	1470	1480	1490	1500
DKAFLSLASD	TVEPTILNAT	NTSLTIRLPL	AKTNLTWYGI	TSPTPTYLVY	YAEVNDRKNS
1510	1520	1530	1540	1550	1560
SDLKYRILEF	QDSIALIEDL	QPFSTYMIQI	AVKNYYSDPL	EHLPPGKEIW	GKTKNGVPEA
1570	1580	1590	1600	1610	1620
VQLINTTVRS	DTSLIISWRE	SHKPNGPKES	VRYQLAISHL	ALIPETPLRQ	SEFPNGRLTL
1630	1640	1650	1660	1670	1680
LVTRLSGGNI	YVLKVLACHS	EEMWCTESHP	VTVEMFNTPE	KPYSLVPENT	SLQFNWKAPL
1690	1700	1710	1720	1730	1740
NVNLIRFWVE	LQKWKYNEFY	HVKTSCSQGP	AYVCNITNLQ	PYTSYNVRVV	VVYKTGENST
1750	1760	1770	1780	1790	1800
SLPESFKTKA	GVPNKPGIPK	LLEGSKNSIQ	WEKAEDNGCR	ITYYILEIRK	STSNNLQNQN
1810	1820	1830	1840	1850	1860
LRWKMTFNGS	CSSVCTWKSK	NLKGIFQFRV	VAANNLGFGE	YSGISENIIL	VGDDFWIPET
1870	1880	1890	1900	1910	1920
SFILTIIVGI	FLVVTIPLTF	VWHRRLKNQK	SAKEGVTVLI	NEDKELAELR	GLAAGVGLAN
1930	1940	1950	1960	1970	1980
ACYAIHTLPT	QEEIENLPAF	PREKLTLRLL	LGSGAFGEVY	EGTAVDILGV	GSGEIKVAVK
1990	2000	2010	2020	2030	2040
TLKKGSTDQE	KIEFLKEAHL	MSKFNHPNIL	KQLGVCLLNE	PQYIILELME	GGDLLTYLRK
2050	2060	2070	2080	2090	2100
ARMATFYGPL	LTLVDLVDLC	VDISKGCVYL	ERMHFIHRDL	AARNCLVSVK	DYTSPRIVKI
2110	2120	2130	2140	2150	2160
GDFGLARDIY	KNDYYRKRGE	GLLPVRWMAP	ESLMDGIFTT	QSDVWSFGIL	IWEILTLGHQ
2170	2180	2190	2200	2210	2220
PYPAHSNLDV	LNYVQTGGRL	EPPRNCPDDL	WNLMTQCWAQ	EPDQRPTFHR	IQDQLQLFRN
2230	2240	2250	2260	2270	2280
FFLNSIYKSR	DEANNSGVIN	ESFEGEDGDV	ICLNSDDIMP	VALMETKNRE	GLNYMVLATE
2290	2300	2310	2320	2330	2340
CGQGEEKSEG	PLGSQESESC	GLRKEEKEPH	ADKDFCQEKQ	VAYCPSGKPE	GLNYACLTHS

GYGDGSD