P08631
EV
Gene name |
HCK |
Protein name |
Tyrosine-protein kinase HCK |
Names |
Hematopoietic cell kinase, Hemopoietic cell kinase, p59-HCK/p60-HCK, p59Hck, p61Hck |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:3055 |
EC number |
2.7.10.2: Protein-tyrosine kinases |
Protein Class |
TYROSINE-PROTEIN KINASE (PTHR24418) |
Descriptions
The Src-family kinases include Src, Hck, Fyn, Lyn, Lck, Yes, Fgr, Blk and Frk. They are involved in diverse cellular functions such as immune responses and cell survival and proliferation. The SH2 domain binds to the C-terminal regulatory tail, facilitating the SH3-SH2-kinase linker interaction. SH3 domain engages the SH2-kinase linker, which adopts a polyproline type II (PPII) helical conformation. These interactions result in the inhibition of the kinase activity of HCK.
Autoinhibitory domains (AIDs)
Target domain |
262-515 (Protein kinase domain) |
Relief mechanism |
Partner binding, Ligand binding |
Assay |
Mutagenesis experiment, Structural analysis |
Target domain |
262-515 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
Structural analysis |
Target domain |
262-515 (Protein kinase domain) |
Relief mechanism |
Ligand binding |
Assay |
Mutagenesis experiment, Structural analysis |
Target domain |
262-515 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
Structural analysis |
Accessory elements
No accessory elements
References
- Register AC et al. (2014) "SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family", Biochemistry, 53, 6910-23
- Boggon TJ et al. (2004) "Structure and regulation of Src family kinases", Oncogene, 23, 7918-27
- Engen JR et al. (2008) "Structure and dynamic regulation of Src-family kinases", Cellular and molecular life sciences : CMLS, 65, 3058-73
- Alvarado JJ et al. (2010) "Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism", The Journal of biological chemistry, 285, 35455-61
- Schindler T et al. (1999) "Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor", Molecular cell, 3, 639-48
Autoinhibited structure
Activated structure
40 structures for P08631
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1AD5 | X-ray | 260 A | A/B | 79-526 | PDB |
| 1BU1 | X-ray | 260 A | A/B/C/D/E/F | 81-137 | PDB |
| 1QCF | X-ray | 200 A | A | 81-526 | PDB |
| 2C0I | X-ray | 230 A | A/B | 81-526 | PDB |
| 2C0O | X-ray | 285 A | A/B | 81-526 | PDB |
| 2C0T | X-ray | 215 A | A/B | 81-526 | PDB |
| 2HCK | X-ray | 300 A | A/B | 79-526 | PDB |
| 2HK5 | X-ray | 200 A | A | 247-514 | PDB |
| 2OI3 | NMR | - | A | 61-141 | PDB |
| 2OJ2 | NMR | - | A | 61-141 | PDB |
| 3HCK | NMR | - | A | 140-245 | PDB |
| 3NHN | X-ray | 261 A | A | 72-256 | PDB |
| 3RBB | X-ray | 235 A | B/D | 79-138 | PDB |
| 3REA | X-ray | 200 A | B/D | 79-138 | PDB |
| 3REB | X-ray | 345 A | B/D | 79-138 | PDB |
| 3VRY | X-ray | 248 A | A/B | 81-526 | PDB |
| 3VRZ | X-ray | 222 A | A/B | 81-526 | PDB |
| 3VS0 | X-ray | 293 A | A/B | 81-526 | PDB |
| 3VS1 | X-ray | 246 A | A/B | 81-526 | PDB |
| 3VS2 | X-ray | 261 A | A/B | 81-526 | PDB |
| 3VS3 | X-ray | 217 A | A/B | 81-526 | PDB |
| 3VS4 | X-ray | 275 A | A/B | 81-526 | PDB |
| 3VS5 | X-ray | 285 A | A/B | 81-526 | PDB |
| 3VS6 | X-ray | 237 A | A/B | 81-526 | PDB |
| 3VS7 | X-ray | 300 A | A/B | 81-526 | PDB |
| 4HCK | NMR | - | A | 72-143 | PDB |
| 4LUD | X-ray | 285 A | A/B | 81-526 | PDB |
| 4LUE | X-ray | 304 A | A/B | 81-526 | PDB |
| 4ORZ | X-ray | 200 A | A | 77-138 | PDB |
| 4U5W | X-ray | 186 A | B/D | 72-242 | PDB |
| 5H09 | X-ray | 195 A | A | 81-526 | PDB |
| 5H0B | X-ray | 165 A | A | 81-526 | PDB |
| 5H0E | X-ray | 210 A | A | 81-526 | PDB |
| 5H0G | X-ray | 180 A | A | 81-526 | PDB |
| 5H0H | X-ray | 172 A | A | 81-526 | PDB |
| 5HCK | NMR | - | A | 72-143 | PDB |
| 5NUH | X-ray | 278 A | C/D | 79-138 | PDB |
| 5ZJ6 | X-ray | 170 A | A/B | 242-521 | PDB |
| 8F2P | X-ray | 263 A | B | 77-140 | PDB |
| AF-P08631-F1 | Predicted | AlphaFoldDB |
363 variants for P08631
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA408554384 rs1267564635 |
3 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
CA408554387 rs1468998146 |
4 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1480472671 CA408554391 |
4 | R>P | No |
ClinGen gnomAD |
|
|
CA313885578 rs957448914 COSM1632231 |
5 | S>P | liver [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs957448914 CA313885574 |
5 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1265557140 CA408554412 |
6 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
rs572159768 CA9805637 |
8 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA408554475 rs1258177173 |
10 | P>L | No |
ClinGen TOPMed |
|
|
rs1274924763 CA408554485 |
11 | G>D | No |
ClinGen TOPMed |
|
|
rs968047363 CA313885599 |
11 | G>S | No |
ClinGen Ensembl |
|
|
rs976335520 CA313885629 |
13 | P>Q | No |
ClinGen TOPMed |
|
|
rs922262149 CA313885639 |
16 | E>* | No |
ClinGen TOPMed gnomAD |
|
|
rs922262149 CA313885638 |
16 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs940391679 CA313885640 |
19 | A>G | No |
ClinGen TOPMed |
|
|
CA408559962 rs1323164384 |
24 | C>G | No |
ClinGen gnomAD |
|
|
CA408559960 rs1323164384 |
24 | C>S | No |
ClinGen gnomAD |
|
|
rs1394542488 CA408560008 |
26 | K>R | No |
ClinGen TOPMed |
|
|
CA408560046 rs1229373172 |
28 | K>R | No |
ClinGen gnomAD |
|
|
CA9805668 rs757364712 |
30 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1365132925 CA408560101 |
32 | V>F | No |
ClinGen gnomAD |
|
|
CA9805670 rs779235798 |
33 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9805671 rs756302449 |
34 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9805672 rs151045621 |
35 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs151045621 CA9805673 |
35 | N>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1600718177 CA408560215 |
39 | K>N | No |
ClinGen Ensembl |
|
|
CA9805674 rs6089165 |
40 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs56029200 VAR_041707 CA9805676 |
44 | A>T | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA408560360 rs34774796 |
45 | S>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA9805678 rs147906206 |
46 | P>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs910292966 CA313898899 |
47 | H>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs141638027 CA9805679 |
49 | P>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1422765678 CA408560460 |
49 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs770523793 CA9805680 |
50 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1163172439 CA408560494 |
51 | Y>F | No |
ClinGen gnomAD |
|
|
rs369611440 CA9805682 |
52 | V>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA313898947 rs146996549 |
52 | V>L | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA313898943 rs146996549 |
52 | V>M | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs546783926 CA9805683 |
53 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA408560559 rs1281202859 |
54 | D>E | No |
ClinGen gnomAD |
|
|
rs1600718322 CA408560602 |
57 | S>P | No |
ClinGen Ensembl |
|
|
CA9805686 rs767954647 |
58 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372621598 CA9805687 |
59 | I>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs760767518 CA9805688 |
59 | I>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760767518 CA313898968 |
59 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408560633 rs372621598 |
59 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs766560741 CA408560657 |
60 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754061875 CA9805690 |
60 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs766560741 CA9805689 |
60 | K>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9805691 rs138094245 |
61 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9805692 rs138094245 |
61 | P>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA408560678 rs1184509117 |
61 | P>S | No |
ClinGen gnomAD |
|
|
rs149121640 CA9805712 COSM723156 |
62 | G>E | lung [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs1195156293 CA408533034 |
62 | G>R | No |
ClinGen TOPMed |
|
|
rs149121640 CA408533037 |
62 | G>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs765493289 CA9805714 |
64 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765493289 CA408533046 |
64 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9805717 rs184537004 |
65 | S>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA9805716 rs758222198 |
65 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs1600720116 CA408533093 |
67 | N>K | No |
ClinGen Ensembl |
|
|
CA9805718 rs148264751 |
67 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA408533115 rs1167628516 |
69 | N>I | No |
ClinGen gnomAD |
|
|
CA408533110 rs1413414704 |
69 | N>Y | No |
ClinGen gnomAD |
|
|
rs369294499 CA313861163 |
71 | P>Q | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs1045389318 CA313861142 |
71 | P>S | No |
ClinGen TOPMed |
|
|
rs756780282 CA9805719 |
74 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201087116 CA9805720 |
75 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA408533231 rs1158259664 |
77 | G>A | No |
ClinGen gnomAD |
|
|
CA313861428 rs866696007 |
78 | S>Y | No |
ClinGen Ensembl |
|
|
CA408533244 rs757231454 |
79 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1455151604 CA408533245 |
80 | D>N | No |
ClinGen gnomAD |
|
|
CA408533247 rs1455151604 |
80 | D>Y | No |
ClinGen gnomAD |
|
|
CA9805738 rs767291366 |
83 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408533346 rs1319323058 |
88 | D>A | No |
ClinGen gnomAD |
|
|
CA313861499 rs867427724 |
90 | E>D | No |
ClinGen Ensembl |
|
|
CA313861496 rs745558831 |
90 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs958650426 CA313861524 |
91 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
CA408533386 rs958650426 |
91 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA9805742 rs373209595 |
92 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9805744 rs758750083 |
94 | H>N | No |
ClinGen ExAC gnomAD |
|
|
rs2227967 CA408533434 |
94 | H>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA408533437 rs2227967 |
94 | H>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs758750083 CA9805743 |
94 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
CA9805746 rs771503154 |
95 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1420861231 CA408533485 |
98 | S>G | No |
ClinGen gnomAD |
|
|
rs6089166 CA313861534 |
98 | S>I | No |
ClinGen Ensembl |
|
|
rs1182470239 CA408533495 |
98 | S>R | No |
ClinGen gnomAD |
|
|
rs375847090 CA408533512 |
99 | F>L | No |
ClinGen ESP gnomAD |
|
|
CA408533520 rs1209340293 |
100 | Q>K | No |
ClinGen TOPMed gnomAD |
|
|
CA9805747 rs777232752 |
102 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs55722810 CA9805748 VAR_041708 |
105 | M>L | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs55722810 CA9805749 |
105 | M>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA408533628 rs1306300754 |
106 | V>A | No |
ClinGen gnomAD |
|
|
rs1392440799 CA408533654 |
108 | L>Q | No |
ClinGen gnomAD |
|
|
rs775916901 CA9805750 |
110 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs1454890953 CA408533823 |
112 | G>R | No |
ClinGen gnomAD |
|
|
rs1400340585 CA408533839 |
113 | E>K | No |
ClinGen TOPMed |
|
|
rs1400340585 CA408533843 |
113 | E>Q | No |
ClinGen TOPMed |
|
|
rs1459752290 CA408533956 |
117 | A>V | No |
ClinGen TOPMed |
|
|
rs146372860 CA313862028 |
118 | R>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9805762 rs146372860 |
118 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9805763 rs200519132 |
118 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA9805765 rs781773764 |
119 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9805767 rs182852728 |
123 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA9805766 rs746368765 |
123 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs998760015 CA9805768 |
125 | E>G | No |
ClinGen TOPMed |
|
|
CA313862039 rs758508228 |
125 | E>K | No |
ClinGen Ensembl |
|
|
rs1459955451 CA408534106 |
126 | G>S | No |
ClinGen gnomAD |
|
|
CA408534134 rs1211903967 |
128 | I>T | No |
ClinGen TOPMed |
|
|
rs768951484 CA9805772 |
130 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1184944268 CA408534225 |
133 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
CA9805774 rs761716878 |
134 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761716878 CA9805775 |
134 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs375313782 CA9805776 |
135 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs760621105 CA9805777 |
135 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs760621105 CA9805778 |
135 | R>P | No |
ClinGen ExAC gnomAD |
|
|
rs758924811 CA9805780 |
136 | V>A | No |
ClinGen ExAC gnomAD |
|
|
COSM2888971 rs753422243 CA9805779 |
136 | V>I | pancreas [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA408534317 rs1286740322 |
138 | S>T | No |
ClinGen gnomAD |
|
|
CA9805782 rs529087706 |
139 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs199725229 CA9805783 |
140 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9805784 rs781676406 |
143 | E>A | No |
ClinGen ExAC gnomAD |
|
|
COSM1176413 rs199815006 CA9805795 |
145 | F>C | endometrium [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC gnomAD |
|
rs1363692716 CA408536851 |
148 | G>V | No |
ClinGen TOPMed |
|
|
rs1568988300 CA408536868 |
150 | S>C | No |
ClinGen Ensembl |
|
|
CA408536882 rs1218995301 |
151 | R>Q | No |
ClinGen gnomAD |
|
|
CA9805796 rs546660596 |
151 | R>W | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs776412545 CA408536904 COSM577196 |
153 | D>H | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs776412545 CA9805797 |
153 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs759131196 CA9805798 |
154 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs866857595 CA313865085 |
154 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA313865087 rs866857595 |
154 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA9805799 rs764653552 |
155 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs752447291 CA9805801 COSM1751377 |
156 | R>H | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA9805802 rs762705057 |
158 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs763769368 CA9805803 |
161 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA9805805 rs528935522 |
162 | G>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1009325846 CA313865119 |
164 | M>K | No |
ClinGen TOPMed gnomAD |
|
|
CA408537032 rs1410424604 |
164 | M>L | No |
ClinGen gnomAD |
|
|
rs868236943 CA313865120 |
169 | M>I | No |
ClinGen Ensembl |
|
|
CA9805809 rs755143804 |
171 | R>P | No |
ClinGen ExAC gnomAD |
|
|
CA9805810 rs755143804 |
171 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA408537138 rs996018966 |
174 | E>D | No |
ClinGen TOPMed |
|
|
rs1223284705 CA408537136 |
174 | E>G | No |
ClinGen gnomAD |
|
|
rs748194379 CA9805811 |
174 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs758453485 CA9805830 |
179 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs778012775 CA9805831 |
181 | S>F | No |
ClinGen ExAC |
|
|
rs757137573 CA9805833 |
184 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408537402 rs1372209110 |
185 | R>* | No |
ClinGen gnomAD |
|
|
rs780859955 CA9805834 |
185 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA9805835 rs199854883 |
187 | Y>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs990773005 CA408537413 |
187 | Y>D | No |
ClinGen Ensembl |
|
|
rs990773005 CA313867125 |
187 | Y>H | No |
ClinGen Ensembl |
|
|
rs372761182 CA9805838 |
188 | D>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM1713321 rs372761182 CA9805837 |
188 | D>N | skin [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs1407938720 CA408537429 |
189 | P>L | No |
ClinGen gnomAD |
|
|
CA9805839 rs768249690 |
189 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9805842 rs376025420 |
190 | R>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs776892739 CA9805843 |
190 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9805841 rs376025420 |
190 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1324946490 CA408537438 |
191 | Q>H | No |
ClinGen gnomAD |
|
|
rs1432952193 CA408537459 |
194 | T>I | No |
ClinGen gnomAD |
|
|
CA9805845 COSM1743470 rs765715998 |
195 | V>M | biliary_tract [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA408537477 rs1276298842 |
197 | H>R | No |
ClinGen TOPMed |
|
|
CA9805848 rs764149571 |
201 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs753175110 CA9805847 |
201 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751576419 CA9805849 |
203 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1260565076 CA408537528 |
205 | N>S | No |
ClinGen gnomAD |
|
|
rs200896933 CA9805851 |
206 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA313867211 rs566299253 |
207 | G>S | No |
ClinGen gnomAD |
|
|
CA408537544 rs745669661 |
208 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745669661 CA9805852 |
208 | F>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1279381587 CA408537560 |
210 | I>L | No |
ClinGen TOPMed |
|
|
CA9805854 rs144393224 COSM1411014 |
213 | R>* | pancreas large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC gnomAD |
|
CA9805855 rs202001086 |
213 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed |
|
|
CA408537586 rs1470096400 |
214 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs768339548 CA9805856 |
215 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1415409702 CA408537600 |
216 | F>L | No |
ClinGen TOPMed |
|
|
rs1382537790 CA408537604 |
217 | S>N | No |
ClinGen gnomAD |
|
|
CA408537614 rs1402628743 |
218 | T>I | No |
ClinGen gnomAD |
|
|
rs778570551 CA9805857 |
219 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA9805858 rs747621818 |
220 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1580986 CA9805859 rs771645978 |
222 | L>M | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs771645978 CA408537634 |
222 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA313867223 rs942838789 |
223 | V>M | No |
ClinGen Ensembl |
|
|
rs1039969128 COSM477993 CA313867224 |
224 | D>N | kidney [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA9805862 rs770193145 |
227 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA9805864 rs570713481 |
227 | K>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA9805863 rs776038055 |
227 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA9805865 rs764513438 |
228 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs766669962 CA9805888 |
229 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs779036282 CA408537701 |
230 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9805890 rs754800488 |
230 | N>T | No |
ClinGen ExAC gnomAD |
|
|
CA9805892 rs752678082 |
231 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA313867578 rs780157389 |
232 | G>E | No |
ClinGen TOPMed |
|
|
CA9805894 rs199531584 |
232 | G>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1248786844 CA408537722 |
234 | C>Y | No |
ClinGen gnomAD |
|
|
CA408537744 rs1173429537 |
237 | L>M | No |
ClinGen TOPMed |
|
|
rs80138575 CA9805897 |
238 | S>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs80138575 CA9805898 |
238 | S>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA313867619 rs917816166 |
239 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
CA9805900 rs774785497 |
240 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748674781 CA9805901 |
240 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA9805902 rs772401418 |
241 | C>* | No |
ClinGen ExAC gnomAD |
|
|
CA9805904 rs760789501 |
242 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA9805903 rs563800077 |
242 | M>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA408537787 rs1203953837 |
245 | K>Q | No |
ClinGen TOPMed |
|
|
rs759472997 CA9805907 |
248 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs765114593 CA9805908 |
249 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1229019246 CA408537871 |
253 | D>E | No |
ClinGen TOPMed |
|
|
CA408537868 rs1255552159 |
253 | D>G | No |
ClinGen TOPMed |
|
|
rs1311934087 CA408537927 |
258 | P>S | No |
ClinGen TOPMed |
|
|
rs763893178 CA9805911 |
259 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1025662 CA9805910 rs189947820 |
259 | R>W | endometrium [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC gnomAD |
|
CA9805912 rs751099785 |
261 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs546287799 CA9805913 |
263 | K>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs370473046 CA9805915 |
266 | K>Q | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1404268172 CA408538046 |
269 | G>R | No |
ClinGen gnomAD |
|
|
rs200867413 CA313867694 |
277 | W>R | No |
ClinGen 1000Genomes |
|
|
CA408538608 rs1156481576 |
282 | N>D | No |
ClinGen gnomAD |
|
|
rs1466331822 CA408538615 |
282 | N>S | No |
ClinGen gnomAD |
|
|
rs779524680 CA9805935 |
285 | T>I | No |
ClinGen ExAC gnomAD |
|
|
COSM1580990 rs200178250 CA9805936 |
291 | T>M | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA408538686 rs1275381117 |
292 | M>V | No |
ClinGen gnomAD |
|
|
rs1427630818 CA408538743 |
296 | S>R | No |
ClinGen gnomAD |
|
|
CA9805938 rs778408622 |
297 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9805939 rs747503111 |
298 | S>* | No |
ClinGen ExAC gnomAD |
|
|
CA313869470 rs747503111 COSM1411018 |
298 | S>L | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs781421982 CA9805941 |
299 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745899437 CA9805943 |
300 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA313869493 rs561857553 |
301 | A>D | No |
ClinGen 1000Genomes |
|
|
rs1479861450 CA408538824 |
304 | A>T | No |
ClinGen gnomAD |
|
|
CA9805948 rs774332986 COSM4136810 |
308 | V>M | ovary [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA9805949 rs761753487 |
311 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA9805951 rs749967117 |
313 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1324120274 CA408538969 |
316 | K>R | No |
ClinGen gnomAD |
|
|
CA9805952 rs760080976 |
319 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA9805953 rs766094857 |
320 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA408539019 rs1483356211 |
321 | H>R | No |
ClinGen TOPMed |
|
|
rs1034351284 CA313869536 |
323 | V>A | No |
ClinGen Ensembl |
|
|
CA313869527 rs959494884 |
323 | V>L | No |
ClinGen TOPMed |
|
|
CA9805956 rs778010407 |
327 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751902493 CA9805957 |
328 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773818337 CA313869552 |
330 | Y>N | No |
ClinGen Ensembl |
|
|
CA9805958 rs757866724 |
333 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA9805960 rs745997826 |
336 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA313869571 rs867865791 |
337 | A>T | No |
ClinGen Ensembl |
|
|
CA313869579 rs372166561 |
337 | A>V | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA408539931 rs1454470263 |
341 | L>F | No |
ClinGen TOPMed |
|
|
rs1279351629 CA408539956 |
343 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1401997824 CA408539949 |
343 | D>N | No |
ClinGen gnomAD |
|
|
rs755187545 CA9805986 |
345 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1276931899 CA408540038 |
347 | S>I | No |
ClinGen TOPMed gnomAD |
|
|
CA408540044 rs1211911241 |
347 | S>R | No |
ClinGen gnomAD |
|
|
CA408540049 rs1346151904 |
348 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
rs747978102 CA9805988 |
350 | G>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1487021447 CA408540117 |
351 | S>G | No |
ClinGen TOPMed gnomAD |
|
|
rs771849634 CA9805989 |
351 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773190531 CA9805990 |
357 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
CA9805991 rs151054795 |
359 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA408542041 rs1317060319 |
365 | I>T | No |
ClinGen Ensembl |
|
|
rs1600742995 CA408542047 |
366 | A>S | No |
ClinGen Ensembl |
|
|
CA408542050 rs1309550404 |
366 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA408542057 rs1358100762 |
367 | E>G | No |
ClinGen gnomAD |
|
|
rs114505022 CA9806020 |
370 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1383454556 CA408542112 |
372 | I>N | No |
ClinGen Ensembl |
|
|
CA408542165 rs1322451136 |
376 | N>S | No |
ClinGen gnomAD |
|
|
rs376354017 CA408542185 |
377 | Y>* | No |
ClinGen Ensembl |
|
|
CA408542211 rs1236060396 |
380 | R>* | No |
ClinGen TOPMed gnomAD |
|
|
CA9806023 rs759670290 |
380 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1247215525 CA408542231 |
382 | L>V | No |
ClinGen gnomAD |
|
|
CA9806024 rs765313394 |
383 | R>* | No |
ClinGen ExAC gnomAD |
|
|
rs181577847 CA9806026 |
384 | A>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA9806027 rs777999649 |
386 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA9806028 rs751356172 |
390 | S>A | No |
ClinGen ExAC gnomAD |
|
|
CA408542310 rs751356172 |
390 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1480255608 CA408542322 |
391 | A>E | No |
ClinGen TOPMed |
|
|
rs781062471 CA9806030 |
394 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA9806031 rs745791291 |
395 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1331568521 CA408542382 |
397 | I>T | No |
ClinGen gnomAD |
|
|
rs145632103 CA9806032 |
404 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA408542456 rs1490535900 |
405 | V>I | No |
ClinGen TOPMed |
|
|
CA408542470 rs1263925999 |
406 | I>T | No |
ClinGen gnomAD |
|
|
CA313874767 rs1055802717 COSM1411029 |
410 | E>K | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs377468533 CA9806034 |
412 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA9806035 COSM1533051 rs768447790 |
413 | A>T | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA408542548 rs1483987583 |
413 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1482373816 CA408542551 |
414 | R>Q | No |
ClinGen gnomAD |
|
|
CA9806036 rs774033506 |
414 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs140392783 CA9806057 |
417 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9806058 rs759842107 |
417 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1569016850 CA408542865 |
421 | I>V | No |
ClinGen Ensembl |
|
|
CA313879123 rs989104715 |
426 | P>L | No |
ClinGen Ensembl |
|
|
CA9806060 rs775939943 |
429 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs202169601 CA9806062 |
433 | S>F | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA408542957 rs1569016933 |
434 | F>S | No |
ClinGen Ensembl |
|
|
rs555782474 CA9806065 |
440 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408543093 rs1247644396 |
447 | L>M | No |
ClinGen TOPMed |
|
|
CA408543108 rs1238286004 |
448 | M>T | No |
ClinGen gnomAD |
|
|
CA408543142 rs541906170 |
450 | I>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs557160696 CA9806070 |
451 | V>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs933820962 CA313879176 |
453 | Y>H | No |
ClinGen TOPMed |
|
|
CA313879195 rs750602420 |
454 | G>D | No |
ClinGen Ensembl |
|
|
rs778488179 CA9806072 |
454 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA313879201 rs750602420 |
454 | G>V | No |
ClinGen Ensembl |
|
|
CA408543190 rs374360915 |
455 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9806074 rs374360915 |
455 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs137871205 CA9806073 |
455 | R>W | No |
ClinGen ESP ExAC gnomAD |
|
|
CA408543198 rs1445409201 |
456 | I>T | No |
ClinGen TOPMed |
|
|
CA408543232 rs1407748072 |
459 | P>S | No |
ClinGen gnomAD |
|
|
rs1254787735 CA408543305 |
460 | G>E | No |
ClinGen TOPMed |
|
|
rs1169387201 CA408543322 |
462 | S>L | No |
ClinGen TOPMed |
|
|
rs765034186 CA9806089 |
464 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1035451800 CA313880681 |
464 | P>T | No |
ClinGen Ensembl |
|
|
CA408543357 rs1424275200 |
468 | R>* | No |
ClinGen TOPMed |
|
|
rs1377985749 CA408543358 |
468 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs752297827 CA9806091 |
469 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA408543377 rs1282463298 |
471 | E>D | No |
ClinGen gnomAD |
|
|
rs757813928 COSM1734178 CA9806092 |
472 | R>C | pancreas [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA9806093 rs369369487 |
472 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs756848531 CA9806095 |
473 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs746647795 CA9806094 |
473 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA408543387 rs1180089596 |
474 | Y>H | No |
ClinGen TOPMed |
|
|
CA9806097 rs749578325 |
475 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749578325 CA408543398 |
475 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1723571 rs780405467 CA9806096 |
475 | R>W | NS [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs769231384 CA9806098 |
476 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs977825653 CA313880750 |
477 | P>S | No |
ClinGen TOPMed |
|
|
rs774699694 CA9806099 |
478 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1025677 rs772909371 CA9806100 |
478 | R>H | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1422875561 CA408543495 |
484 | E>G | No |
ClinGen gnomAD |
|
|
rs1400808211 CA408543526 |
487 | Y>C | No |
ClinGen gnomAD |
|
|
CA9806102 rs200005064 |
487 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs1414057960 CA408543541 |
488 | N>K | No |
ClinGen gnomAD |
|
|
COSM1580992 CA408543537 rs1468091314 |
488 | N>S | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs760982143 CA9806103 |
489 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA9806104 rs771236044 |
490 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA313880785 rs142491977 |
490 | M>V | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs1278091557 CA408543574 |
491 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
rs997336181 CA313880787 |
492 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
COSM443620 CA9806105 rs760472522 |
492 | R>H | breast [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA408543639 rs1600755745 |
496 | N>K | No |
ClinGen Ensembl |
|
|
CA9806106 rs759226436 |
497 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA408543646 rs1344765069 |
497 | R>H | No |
ClinGen gnomAD |
|
|
rs752568964 CA9806108 COSM1411040 |
498 | P>L | large_intestine central_nervous_system [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA408543656 rs752568964 COSM3693427 |
498 | P>Q | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs765257294 CA9806107 |
498 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1211037780 CA408543678 COSM347972 |
500 | E>K | lung [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1195764093 CA408543691 |
501 | R>Q | No |
ClinGen gnomAD |
|
|
rs1487246529 CA408543689 |
501 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
VAR_033836 CA313880842 rs17093828 |
502 | P>Q | No |
ClinGen UniProt ESP TOPMed dbSNP |
|
|
rs17093828 CA313880840 |
502 | P>R | No |
ClinGen ESP TOPMed |
|
|
CA408543725 rs1305011634 |
504 | F>L | No |
ClinGen TOPMed |
|
|
rs756936393 CA408543729 |
505 | E>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780777361 CA9806113 |
505 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9806112 rs756936393 |
505 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9806114 rs754280289 |
509 | S>I | No |
ClinGen ExAC gnomAD |
|
|
CA408543857 rs1299403458 COSM723148 |
515 | Y>C | lung [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs755269188 CA9806115 |
515 | Y>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs961741242 CA313880866 |
516 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1600755957 CA408543894 RCV000997767 |
519 | E>* | No |
ClinGen ClinVar Ensembl dbSNP |
|
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CA408543909 rs1272690032 |
520 | S>N | No |
ClinGen gnomAD |
|
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rs1266399689 CA408543917 |
520 | S>R | No |
ClinGen TOPMed |
|
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rs1451608977 CA408544011 |
527 | P>W | No |
ClinGen TOPMed |
2 associated diseases with P08631
Without disease ID
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.2 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | PTHR24418 | TYROSINE-PROTEIN KINASE |
| PANTHER Subfamily | PTHR24418:SF245 | TYROSINE-PROTEIN KINASE HCK |
| PANTHER Protein Class | non-receptor tyrosine protein kinase | |
| PANTHER Pathway Category |
Parkinson disease Src kinase |
|
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| caveola | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. |
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| transport vesicle | Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. |
| phosphotyrosine residue binding | Binding to a phosphorylated tyrosine residue within a protein. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
28 GO annotations of biological process
| Name | Definition |
|---|---|
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cytokine-mediated signaling pathway | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| Fc-gamma receptor signaling pathway involved in phagocytosis | An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| innate immune response-activating signal transduction | The series of molecular signals generated as a consequence of a pathogen or microbial effector binding to a plant 'resistance-gene' receptor to activate a plant immune response, usually plant-type hypersensitive response. |
| integrin-mediated signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| interferon-gamma-mediated signaling pathway | The series of molecular signals initiated by interferon-gamma binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far. |
| leukocyte degranulation | The regulated exocytosis of secretory granules by a leukocyte. |
| leukocyte migration involved in immune response | The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response. |
| lipopolysaccharide-mediated signaling pathway | The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. |
| mesoderm development | The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of inflammatory response to antigenic stimulus | Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. |
| peptidyl-tyrosine phosphorylation | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
| positive regulation of actin cytoskeleton reorganization | Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization. |
| positive regulation of actin filament polymerization | Any process that activates or increases the frequency, rate or extent of actin polymerization. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| regulation of DNA-binding transcription factor activity | Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. |
| regulation of phagocytosis | Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. |
| regulation of podosome assembly | Any process that modulates the frequency, rate or extent of podosome assembly. |
| respiratory burst after phagocytosis | A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
90 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0JNB0 | FYN | Tyrosine-protein kinase Fyn | Bos taurus (Bovine) | SS |
| Q0VBZ0 | CSK | Tyrosine-protein kinase CSK | Bos taurus (Bovine) | SS |
| Q3ZC95 | BTK | Tyrosine-protein kinase | Bos taurus (Bovine) | EV SS |
| P42683 | LCK | Proto-oncogene tyrosine-protein kinase LCK | Gallus gallus (Chicken) | SS |
| P41239 | CSK | Tyrosine-protein kinase CSK | Gallus gallus (Chicken) | SS |
| P00523 | SRC | Proto-oncogene tyrosine-protein kinase Src | Gallus gallus (Chicken) | EV |
| Q02977 | YRK | Proto-oncogene tyrosine-protein kinase Yrk | Gallus gallus (Chicken) | SS |
| Q8JH64 | BTK | Tyrosine-protein kinase BTK | Gallus gallus (Chicken) | SS |
| P09324 | YES1 | Tyrosine-protein kinase Yes | Gallus gallus (Chicken) | SS |
| Q05876 | FYN | Tyrosine-protein kinase Fyn | Gallus gallus (Chicken) | SS |
| Q75R65 | JAK2 | Tyrosine-protein kinase JAK2 | Gallus gallus (Chicken) | SS |
| Q24592 | hop | Tyrosine-protein kinase hopscotch | Drosophila melanogaster (Fruit fly) | PR |
| P08630 | Btk | Tyrosine-protein kinase Btk | Drosophila melanogaster (Fruit fly) | SS |
| Q9V9J3 | Src42A | Tyrosine-protein kinase Src42A | Drosophila melanogaster (Fruit fly) | SS |
| P00528 | Src64B | Tyrosine-protein kinase Src64B | Drosophila melanogaster (Fruit fly) | SS |
| P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Homo sapiens (Human) | SS |
| O60674 | JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens (Human) | EV |
| P52333 | JAK3 | Tyrosine-protein kinase JAK3 | Homo sapiens (Human) | SS |
| P29597 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | Homo sapiens (Human) | EV |
| P43405 | SYK | Tyrosine-protein kinase SYK | Homo sapiens (Human) | EV |
| P43403 | ZAP70 | Tyrosine-protein kinase ZAP-70 | Homo sapiens (Human) | EV |
| Q13882 | PTK6 | Protein-tyrosine kinase 6 | Homo sapiens (Human) | EV |
| P09769 | FGR | Tyrosine-protein kinase Fgr | Homo sapiens (Human) | SS |
| P07948 | LYN | Tyrosine-protein kinase Lyn | Homo sapiens (Human) | SS |
| P06241 | FYN | Tyrosine-protein kinase Fyn | Homo sapiens (Human) | SS |
| P12931 | SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (Human) | EV |
| P06239 | LCK | Tyrosine-protein kinase Lck | Homo sapiens (Human) | EV |
| P51451 | BLK | Tyrosine-protein kinase Blk | Homo sapiens (Human) | SS |
| P07947 | YES1 | Tyrosine-protein kinase Yes | Homo sapiens (Human) | SS |
| P42685 | FRK | Tyrosine-protein kinase FRK | Homo sapiens (Human) | EV |
| Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Homo sapiens (Human) | EV |
| Q06187 | BTK | Tyrosine-protein kinase BTK | Homo sapiens (Human) | EV |
| P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Homo sapiens (Human) | SS |
| P42680 | TEC | Tyrosine-protein kinase Tec | Homo sapiens (Human) | SS |
| P42679 | MATK | Megakaryocyte-associated tyrosine-protein kinase | Homo sapiens (Human) | SS |
| P41240 | CSK | Tyrosine-protein kinase CSK | Homo sapiens (Human) | SS |
| Q14289 | PTK2B | Protein-tyrosine kinase 2-beta | Homo sapiens (Human) | PR |
| Q05397 | PTK2 | Focal adhesion kinase 1 | Homo sapiens (Human) | EV |
| Q13470 | TNK1 | Non-receptor tyrosine-protein kinase TNK1 | Homo sapiens (Human) | PR |
| Q07912 | TNK2 | Activated CDC42 kinase 1 | Homo sapiens (Human) | EV |
| P16591 | FER | Tyrosine-protein kinase Fer | Homo sapiens (Human) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P42684 | ABL2 | Tyrosine-protein kinase ABL2 | Homo sapiens (Human) | SS |
| P00519 | ABL1 | Tyrosine-protein kinase ABL1 | Homo sapiens (Human) | EV |
| Q9R117 | Tyk2 | Non-receptor tyrosine-protein kinase TYK2 | Mus musculus (Mouse) | SS |
| P16277 | Blk | Tyrosine-protein kinase Blk | Mus musculus (Mouse) | SS |
| Q62270 | Srms | Tyrosine-protein kinase Srms | Mus musculus (Mouse) | SS |
| Q64434 | Ptk6 | Protein-tyrosine kinase 6 | Mus musculus (Mouse) | SS |
| P05480 | Src | Proto-oncogene tyrosine-protein kinase Src | Mus musculus (Mouse) | EV |
| P14234 | Fgr | Tyrosine-protein kinase Fgr | Mus musculus (Mouse) | SS |
| P35991 | Btk | Tyrosine-protein kinase BTK | Mus musculus (Mouse) | EV |
| P41241 | Csk | Tyrosine-protein kinase CSK | Mus musculus (Mouse) | EV |
| P25911 | Lyn | Tyrosine-protein kinase Lyn | Mus musculus (Mouse) | EV |
| Q62137 | Jak3 | Tyrosine-protein kinase JAK3 | Mus musculus (Mouse) | SS |
| Q62120 | Jak2 | Tyrosine-protein kinase JAK2 | Mus musculus (Mouse) | EV |
| P06240 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Mus musculus (Mouse) | SS |
| P24604 | Tec | Tyrosine-protein kinase Tec | Mus musculus (Mouse) | SS |
| Q04736 | Yes1 | Tyrosine-protein kinase Yes | Mus musculus (Mouse) | SS |
| P39688 | Fyn | Tyrosine-protein kinase Fyn | Mus musculus (Mouse) | SS |
| P52332 | Jak1 | Tyrosine-protein kinase JAK1 | Mus musculus (Mouse) | SS |
| Q03526 | Itk | Tyrosine-protein kinase ITK/TSK | Mus musculus (Mouse) | SS |
| P41242 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q922K9 | Frk | Tyrosine-protein kinase FRK | Mus musculus (Mouse) | SS |
| P08103 | Hck | Tyrosine-protein kinase HCK | Mus musculus (Mouse) | SS |
| A1Y2K1 | FYN | Tyrosine-protein kinase Fyn | Sus scrofa (Pig) | SS |
| O19064 | JAK2 | Tyrosine-protein kinase JAK2 | Sus scrofa (Pig) | SS |
| Q62662 | Frk | Tyrosine-protein kinase FRK | Rattus norvegicus (Rat) | SS |
| Q62844 | Fyn | Tyrosine-protein kinase Fyn | Rattus norvegicus (Rat) | SS |
| Q07014 | Lyn | Tyrosine-protein kinase Lyn | Rattus norvegicus (Rat) | SS |
| Q9WUD9 | Src | Proto-oncogene tyrosine-protein kinase Src | Rattus norvegicus (Rat) | SS |
| Q01621 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Rattus norvegicus (Rat) | SS |
| Q6P6U0 | Fgr | Tyrosine-protein kinase Fgr | Rattus norvegicus (Rat) | SS |
| Q62689 | Jak2 | Tyrosine-protein kinase JAK2 | Rattus norvegicus (Rat) | SS |
| Q63272 | Jak3 | Tyrosine-protein kinase JAK3 | Rattus norvegicus (Rat) | SS |
| P32577 | Csk | Tyrosine-protein kinase CSK | Rattus norvegicus (Rat) | SS |
| P41243 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Rattus norvegicus (Rat) | SS |
| F1LM93 | Yes1 | Tyrosine-protein kinase Yes | Rattus norvegicus (Rat) | SS |
| P50545 | Hck | Tyrosine-protein kinase HCK | Rattus norvegicus (Rat) | SS |
| G5ECJ6 | csk-1 | Tyrosine-protein kinase csk-1 | Caenorhabditis elegans | SS |
| O45539 | src-2 | Tyrosine protein-kinase src-2 | Caenorhabditis elegans | SS |
| G5EE56 | src-1 | Tyrosine protein-kinase src-1 | Caenorhabditis elegans | SS |
| F4JTP5 | STY46 | Serine/threonine-protein kinase STY46 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22558 | STY8 | Serine/threonine-protein kinase STY8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q2MHE4 | HT1 | Serine/threonine/tyrosine-protein kinase HT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWL6 | STY17 | Serine/threonine-protein kinase STY17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A1A5H8 | yes1 | Tyrosine-protein kinase yes | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F1RDG9 | fynb | Tyrosine-protein kinase fynb | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O12990 | jak1 | Tyrosine-protein kinase JAK1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q1JPZ3 | src | Proto-oncogene tyrosine-protein kinase Src | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6EWH2 | fyna | Tyrosine-protein kinase fyna | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGGRSSCEDP | GCPRDEERAP | RMGCMKSKFL | QVGGNTFSKT | ETSASPHCPV | YVPDPTSTIK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PGPNSHNSNT | PGIREAGSED | IIVVALYDYE | AIHHEDLSFQ | KGDQMVVLEE | SGEWWKARSL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ATRKEGYIPS | NYVARVDSLE | TEEWFFKGIS | RKDAERQLLA | PGNMLGSFMI | RDSETTKGSY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLSVRDYDPR | QGDTVKHYKI | RTLDNGGFYI | SPRSTFSTLQ | ELVDHYKKGN | DGLCQKLSVP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CMSSKPQKPW | EKDAWEIPRE | SLKLEKKLGA | GQFGEVWMAT | YNKHTKVAVK | TMKPGSMSVE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AFLAEANVMK | TLQHDKLVKL | HAVVTKEPIY | IITEFMAKGS | LLDFLKSDEG | SKQPLPKLID |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FSAQIAEGMA | FIEQRNYIHR | DLRAANILVS | ASLVCKIADF | GLARVIEDNE | YTAREGAKFP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IKWTAPEAIN | FGSFTIKSDV | WSFGILLMEI | VTYGRIPYPG | MSNPEVIRAL | ERGYRMPRPE |
| 490 | 500 | 510 | 520 | ||
| NCPEELYNIM | MRCWKNRPEE | RPTFEYIQSV | LDDFYTATES | QYQQQP |