AiPD: Autoinhibited Protein Database

P08151

Gene name	GLI1 (GLI)
Protein name	Zinc finger protein GLI1
Names	Glioma-associated oncogene, Oncogene GLI
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2735
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

495-577 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

495-577 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for P08151

Entry ID	Method	Resolution	Chain	Position	Source
2GLI	X-ray	260 A	A	234-388	PDB
4BLB	X-ray	280 A	E/F/G/H	115-131	PDB
4KMD	X-ray	170 A	B	112-128	PDB
5OM0	X-ray	320 A	A/B	637-645	PDB
7T91	X-ray	205 A	A/B	234-302	PDB
AF-P08151-F1	Predicted				AlphaFoldDB

943 variants for P08151

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA385461302 rs748321474 RCV000680279	113	R>*	Polydactyly, postaxial, type A8 [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
VAR_081480	113	R>del	PAPA8 [UniProt]	Yes	UniProt
rs193921005 RCV000149082 CA174313 COSM1178809	177	C>Y	Malignant tumor of prostate prostate haematopoietic_and_lymphoid_tissue [ClinVar, Cosmic]	Yes	ClinGen cosmic curated ClinVar Ensembl dbSNP
rs563340967 RCV000585767 CA6648621	274	G>R	Bardet-Biedl syndrome Bardet-biedl syndrome (bbs) [ClinVar, Ensembl]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV001261999 rs1871565914	329	K>*	Polydactyly, postaxial, type A8 [ClinVar]	Yes	ClinVar dbSNP
CA6648801 rs753690500 RCV000770752 VAR_082590	506	L>Q	PPD1; unknown pathological significance [UniProt]	Yes	ClinGen ClinVar UniProt ExAC TOPMed dbSNP gnomAD
RCV000680278 rs1565601979 CA385470890	644	Q>*	Polydactyly, postaxial, type A8 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
VAR_081481	644	Q>del	PAPA8 [UniProt]	Yes	UniProt
rs1871871826 RCV001270223	743	Y>H	Premature ovarian failure [ClinVar]	Yes	ClinVar dbSNP
RCV000680277 CA385473122 rs1309855392	780	W>*	Polydactyly, postaxial, type A8 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP
VAR_081482	780	W>del	PAPA8; decreased transcriptional activity; reduced expression of the GLI1 target PTCH1 observed in patient fibroblasts after chemical induction of the hedgehog pathway [UniProt]	Yes	UniProt
RCV001334380 rs1871977265	1022	G>missing	Polydactyly, postaxial, type A8 [ClinVar]	Yes	ClinVar dbSNP
TCGA novel	2	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6648325 rs779451445	3	N>T		No	ClinGen ExAC gnomAD
CA6648326 rs141757554	4	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1594742252 CA385459655	6	T>P		No	ClinGen Ensembl
rs1311532229 CA385459702	9	P>Q		No	ClinGen TOPMed
CA6648330 rs533354109	10	I>M		No	ClinGen 1000Genomes ExAC gnomAD
rs748024303 CA6648329	10	I>V		No	ClinGen ExAC gnomAD
rs1010940668 CA237783168	11	S>N		No	ClinGen TOPMed
CA385459751 rs1313805644	13	Y>C		No	ClinGen gnomAD
CA385459755 rs1377673984	14	G>S		No	ClinGen gnomAD
CA6648331 rs773228040	14	G>V		No	ClinGen ExAC TOPMed gnomAD
CA6648333 rs766446724	15	E>A		No	ClinGen ExAC gnomAD
CA237783188 rs890327478	15	E>K		No	ClinGen TOPMed
CA6648334 rs552135928	16	P>H		No	ClinGen 1000Genomes ExAC gnomAD
CA6648335 rs759777434	19	L>F		No	ClinGen ExAC TOPMed gnomAD
CA6648337 rs199861974	20	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199861974 CA237783225	20	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767782645 CA6648336 COSM942034	20	R>W	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6648338 rs756402955	23	P>A		No	ClinGen ExAC gnomAD
CA385459868 rs1429409127	23	P>L		No	ClinGen gnomAD
rs1566558142 CA385459894	25	Q>P		No	ClinGen Ensembl
CA6648340 rs764455953	26	G>E		No	ClinGen ExAC TOPMed gnomAD
rs754294090 CA385459926	27	A>D		No	ClinGen ExAC gnomAD
rs754294090 CA6648341	27	A>V		No	ClinGen ExAC gnomAD
rs200183475 CA237783273	28	P>S		No	ClinGen gnomAD
TCGA novel	31	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6648342 rs757744788	31	G>E		No	ClinGen ExAC gnomAD
rs779593964 CA6648343	32	T>R		No	ClinGen ExAC gnomAD
TCGA novel	33	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746560370 CA6648344	33	E>G		No	ClinGen ExAC TOPMed gnomAD
CA237783284 rs1035246842	33	E>Q		No	ClinGen TOPMed
rs1440421197 CA385460055	34	G>E		No	ClinGen TOPMed
rs1383562588 CA385460006	34	G>R		No	ClinGen gnomAD
CA237783433 rs936956795	35	L>M		No	ClinGen Ensembl
CA385460085 rs1165299385	37	G>S		No	ClinGen gnomAD
CA385460104 rs1392573638 COSM1253287	38	P>L	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA385460107 rs1418545492	39	P>S		No	ClinGen TOPMed
TCGA novel	41	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1594742645 CA385460139	42	H>P		No	ClinGen Ensembl
rs1236664410 CA385460151	43	Q>E		No	ClinGen gnomAD
rs780874033 CA6648364	45	N>K		No	ClinGen ExAC TOPMed gnomAD
CA385460191 rs1328811148	46	L>F		No	ClinGen TOPMed gnomAD
CA385460212 rs1594742670	47	M>T		No	ClinGen Ensembl
rs537495636 CA6648367	49	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs537495636 CA6648366	49	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs749091656 CA6648368	52	S>G		No	ClinGen ExAC gnomAD
CA385460289 rs1566558325	53	Y>N		No	ClinGen Ensembl
CA385460319 rs1566558352	55	P>S		No	ClinGen Ensembl
rs770894336 CA6648369	56	A>V		No	ClinGen ExAC TOPMed gnomAD
rs778646808 CA6648370	57	R>S		No	ClinGen ExAC gnomAD
rs1272787826 CA385460349	57	R>T		No	ClinGen TOPMed
rs1362862333 CA385460354	58	E>K		No	ClinGen TOPMed gnomAD
CA385460357 rs1362862333	58	E>Q		No	ClinGen TOPMed gnomAD
rs375170232 CA6648371	59	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6648372 rs772090740	63	T>S		No	ClinGen ExAC gnomAD
CA6648374 rs760866050	64	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1389442591 CA385460467	65	G>C		No	ClinGen gnomAD
rs1389442591 CA385460463	65	G>S		No	ClinGen gnomAD
CA6648397 rs770016487	67	L>F		No	ClinGen ExAC gnomAD
CA6648400 rs773669041	69	S>A		No	ClinGen ExAC gnomAD
rs763536538 CA6648401	69	S>F		No	ClinGen ExAC gnomAD
rs773669041 CA385460605	69	S>T		No	ClinGen ExAC gnomAD
TCGA novel	69	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760192848 CA385460645	72	R>P		No	ClinGen ExAC TOPMed gnomAD
rs760192848 CA6648405	72	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs199685332 CA6648403	72	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1395670869 CA385460671	74	A>T		No	ClinGen gnomAD
CA385460687 rs1436341580	75	V>I		No	ClinGen gnomAD
rs267603602 CA237784086	76	K>N		No	ClinGen Ensembl
CA385460715 rs1310917004	78	T>A		No	ClinGen gnomAD
CA6648406 rs763670345	80	K>R		No	ClinGen ExAC TOPMed gnomAD
CA385460768 rs1289476480	81	R>L		No	ClinGen TOPMed gnomAD
rs1289476480 CA385460765	81	R>Q		No	ClinGen TOPMed gnomAD
CA6648407 rs753380800	81	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6648409 rs144785382	84	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1364213000 CA385460795	84	S>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6648408 rs144785382	84	S>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs750276505 CA6648410	85	I>V		No	ClinGen ExAC gnomAD
CA6648411 rs758328227	86	S>*		No	ClinGen ExAC gnomAD
CA6648412 rs779901915	87	P>S		No	ClinGen ExAC gnomAD
CA385460842 rs1415914630	88	L>P		No	ClinGen TOPMed
COSM3417025 rs746964085 CA6648413	89	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs781367133 CA6648415	90	D>V		No	ClinGen ExAC gnomAD
CA6648416 rs748291467	91	A>T		No	ClinGen ExAC gnomAD
rs770107383 CA6648417	92	S>N		No	ClinGen ExAC gnomAD
rs1253544916 CA385460960	94	D>A		No	ClinGen gnomAD
rs143548857 CA6648418	97	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA6648422 COSM333546 rs760141461	100	R>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA385461084 rs763470494	100	R>H		No	ClinGen ExAC TOPMed gnomAD
CA6648423 rs763470494	100	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1419694903 CA385461111	101	T>I		No	ClinGen TOPMed
CA385461119 rs1320048458	102	S>P		No	ClinGen gnomAD
CA237784177 rs1029168886	103	P>S		No	ClinGen TOPMed
CA237784184 rs889338993	104	S>G		No	ClinGen Ensembl
CA237784191 rs776244778	104	S>N		No	ClinGen ExAC gnomAD
CA385461169 rs1566558833	104	S>R		No	ClinGen Ensembl
CA6648424 rs776244778	104	S>T		No	ClinGen ExAC gnomAD
rs1018955380 CA237784202	105	S>T		No	ClinGen gnomAD
rs139570630 CA6648425 RCV000973726	105	S>Y		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1344789388 CA385461192	106	L>F		No	ClinGen TOPMed gnomAD
rs1285900168 CA385461208	107	V>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6648426 rs765007750	108	A>T		No	ClinGen ExAC gnomAD
CA237784219 rs1011225180	108	A>V		No	ClinGen TOPMed gnomAD
CA6648428 rs758132104	109	F>V		No	ClinGen ExAC gnomAD
CA6648429 rs766185741	110	I>F		No	ClinGen ExAC gnomAD
CA385461269 rs1260473262	110	I>S		No	ClinGen TOPMed
CA385461260 rs766185741	110	I>V		No	ClinGen ExAC gnomAD
CA385461282 rs1202951566	111	N>S		No	ClinGen TOPMed
CA6648430 rs751461298 COSM942036	112	S>L	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM84174 CA6648434 rs756282060	113	R>Q	Variant assessed as Somatic; 0.0001386 impact. pancreas endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6648435 rs375940413	115	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs774885952 CA6648438	117	P>S		No	ClinGen ExAC gnomAD
rs1243003218 CA385461415	119	G>D		No	ClinGen Ensembl
rs772683970 CA6648440	120	S>F		No	ClinGen ExAC gnomAD
rs150011919 CA6648442	121	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs367757660 CA6648444	122	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs367757660 CA6648443	122	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA385461518 rs1317745506	126	I>T		No	ClinGen TOPMed
CA385461528 rs751408248	127	G>A		No	ClinGen ExAC gnomAD
CA6648448 rs751408248	127	G>D		No	ClinGen ExAC gnomAD
rs766134206 COSM1299714 CA6648447	127	G>S	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1476006703 CA385461997	133	L>V		No	ClinGen gnomAD
CA237784472 rs889329214	135	F>L		No	ClinGen gnomAD
rs368173104 CA237784480	136	P>A		No	ClinGen ESP
rs1298522895 CA385462041	136	P>Q		No	ClinGen gnomAD
CA6648470 rs145283539	137	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA237784493 rs1019239130	138	Q>H		No	ClinGen TOPMed
TCGA novel	139	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs898082922 CA237784506	139	M>K		No	ClinGen Ensembl
rs199696648 CA6648471	139	M>V		No	ClinGen 1000Genomes ExAC gnomAD
CA6648472 rs764236015	140	N>K		No	ClinGen ExAC gnomAD
TCGA novel	142	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385462122 rs1393937734	142	Q>K		No	ClinGen gnomAD
rs1281162936 CA690269874	142	Q>R		No	ClinGen TOPMed
CA385462158 rs1233812896	144	G>W		No	ClinGen TOPMed
CA6648473 rs754019701	146	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	146	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371590132 CA6648476	147	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs758741662 CA6648477	148	S>A		No	ClinGen ExAC gnomAD
rs780316234 COSM4152909 CA6648478	149	F>S	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA6648479 rs554594367	150	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA237784550 rs773331571	151	V>F		No	ClinGen TOPMed gnomAD
rs777248037 CA6648482	153	P>L		No	ClinGen ExAC gnomAD
rs777248037 CA6648481	153	P>R		No	ClinGen ExAC gnomAD
CA385462223 rs1255791245	154	C>F		No	ClinGen TOPMed gnomAD
CA6648483 rs202066753	154	C>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA237784621 rs944167135	156	P>R		No	ClinGen TOPMed
rs774001028 CA385462233	156	P>S		No	ClinGen ExAC TOPMed gnomAD
rs774001028 CA6648484	156	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1039477087 CA237784643	157	H>R		No	ClinGen TOPMed gnomAD
CA237784627 rs867870031	157	H>Y		No	ClinGen Ensembl
rs1022750237 CA237784645	160	A>P		No	ClinGen Ensembl
COSM1363303 CA6648486 rs149185944	161	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA6648485 rs142957882	161	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1397293500 CA385462306	162	G>S		No	ClinGen gnomAD
CA385462313 rs1464194780	162	G>V		No	ClinGen gnomAD
rs1385280044 CA385462322	163	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1486969055 CA385462335	164	M>T		No	ClinGen TOPMed
CA237784648 rs971226763	167	H>Y		No	ClinGen TOPMed
CA6648489 rs542007910	168	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs542007910 CA6648488 RCV000904895	168	P>R		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs776846382 CA6648490	171	R>G		No	ClinGen ExAC TOPMed gnomAD
rs765428970 CA6648492	171	R>Q		No	ClinGen ExAC gnomAD
CA6648491 rs776846382	171	R>W		No	ClinGen ExAC TOPMed gnomAD
CA385462444 rs1224544686	172	G>A		No	ClinGen TOPMed
rs1224544686 CA385462440	172	G>E		No	ClinGen TOPMed
CA6648493 rs750617572	172	G>R		No	ClinGen ExAC gnomAD
TCGA novel	173	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385462455 rs1232329180	173	P>R		No	ClinGen gnomAD
CA6648495 rs766741235	175	P>L		No	ClinGen ExAC TOPMed gnomAD
rs956153433 CA237784660	176	T>A		No	ClinGen gnomAD
rs956153433 CA385462494	176	T>S		No	ClinGen gnomAD
CA385462651 rs1179532652	182	E>V		No	ClinGen gnomAD
CA6648513 rs766573156	183	L>P		No	ClinGen ExAC gnomAD
CA6648514 rs751780759	185	M>I		No	ClinGen ExAC gnomAD
CA6648515 rs755282838	189	K>T		No	ClinGen ExAC gnomAD
CA385462735 rs1281870068	190	C>G		No	ClinGen TOPMed
rs767895421 CA6648516	190	C>Y		No	ClinGen ExAC gnomAD
rs151317566 CA6648519	191	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756656703 CA6648518	191	R>W		No	ClinGen ExAC TOPMed gnomAD
CA237784929 CA385462775 rs2228225	192	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6648520 rs375756845	192	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs867823477 CA237784930	193	E>K		No	ClinGen Ensembl
CA6648522 rs779506563	194	P>S		No	ClinGen ExAC gnomAD
rs1314946688 CA385462853	197	G>A		No	ClinGen gnomAD
CA6648523 rs746681579	198	D>G		No	ClinGen ExAC gnomAD
CA385462860 rs1320393599	198	D>H		No	ClinGen gnomAD
rs746681579 CA385462867	198	D>V		No	ClinGen ExAC gnomAD
CA237784944 rs953723851	199	M>I		No	ClinGen Ensembl
CA6648524 rs768531179	200	S>P		No	ClinGen ExAC gnomAD
rs776606983 CA6648525	202	P>L		No	ClinGen ExAC gnomAD
CA6648526 rs748075302	204	S>A		No	ClinGen ExAC gnomAD
rs868274692 CA237784967	206	G>D		No	ClinGen Ensembl
rs769675836 CA385463012	208	Q>*		No	ClinGen ExAC gnomAD
rs769675836 CA6648527	208	Q>E		No	ClinGen ExAC gnomAD
rs1409773154 CA385463025	208	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	209	D>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6648544 rs769632060	209	D>V		No	ClinGen ExAC TOPMed gnomAD
VAR_035557	210	P>A	a breast cancer sample; somatic mutation [UniProt]	No	UniProt
CA6648548 rs777509564	212	L>F		No	ClinGen ExAC gnomAD
rs1221339030 CA385463120	213	G>R		No	ClinGen gnomAD
CA6648549 rs200793383	214	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs145720544 CA385463155	216	D>N		No	ClinGen ESP TOPMed gnomAD
rs138672716 CA6648550	216	D>V		No	ClinGen ESP ExAC TOPMed
CA237785060 rs145720544	216	D>Y		No	ClinGen ESP TOPMed gnomAD
CA237785065 rs1040509893	218	R>Q		No	ClinGen TOPMed gnomAD
CA385463182 rs1215799189	218	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs759734150 CA6648552	219	E>K		No	ClinGen ExAC TOPMed gnomAD
CA237785103 rs929570412	220	D>G		No	ClinGen Ensembl
CA385463205 rs1455558333	220	D>Y		No	ClinGen TOPMed
rs1478880212 CA385463219	221	L>F		No	ClinGen gnomAD
rs772340309 CA6648553	221	L>H		No	ClinGen ExAC gnomAD
COSM3688367 CA6648554 rs369404558	222	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA6648555 rs760883025	223	R>K		No	ClinGen ExAC gnomAD
CA237785145 rs754258666	225	E>D		No	ClinGen ExAC TOPMed gnomAD
rs764532761 CA6648557	225	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1566559797	225	E>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs762421780 CA6648559	226	K>E		No	ClinGen ExAC gnomAD
rs200097138 CA6648562 COSM942038	227	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs200097138 CA6648561	227	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6648564 rs202128734	227	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6648563 rs202128734	227	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755812887 CA6648565	229	P>S		No	ClinGen ExAC gnomAD
CA6648566 rs777659251	231	S>C		No	ClinGen ExAC TOPMed gnomAD
rs777659251 CA237785171	231	S>F		No	ClinGen ExAC TOPMed gnomAD
rs770953450 CA6648568	232	V>E		No	ClinGen ExAC gnomAD
CA6648567 rs749153176	232	V>L		No	ClinGen ExAC gnomAD
CA385463401 rs1273736602	235	T>N		No	ClinGen gnomAD
rs1295583467 CA385463404	236	D>N		No	ClinGen TOPMed
CA385463424 rs1234477341	237	C>Y		No	ClinGen TOPMed
CA6648570 rs746017407	238	R>C		No	ClinGen ExAC gnomAD
rs548133983 CA6648571	238	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385463496 rs1183121569	242	C>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA385463528 rs1471642360	244	Q>R		No	ClinGen gnomAD
TCGA novel	245	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6648573 rs747277465	246	F>V		No	ClinGen ExAC gnomAD
rs1594744867 CA385463576	247	D>A		No	ClinGen Ensembl
CA237785228 rs867676131	247	D>E		No	ClinGen gnomAD
rs768871917 CA6648574	248	S>F		No	ClinGen ExAC TOPMed
rs1321934189 CA385463604	249	Q>H		No	ClinGen gnomAD
rs1349631593 CA385463617	250	E>G		No	ClinGen gnomAD
TCGA novel	251	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1227177051 CA385463638	253	V>E		No	ClinGen TOPMed gnomAD
rs773802622 CA6648600	255	H>D		No	ClinGen ExAC gnomAD
CA237785478 rs113210621	256	I>V		No	ClinGen TOPMed
TCGA novel	258	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs150321991 CA237785505	258	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA237785536 rs775119859	259	E>*		No	ClinGen ExAC TOPMed gnomAD
CA6648603 rs775119859	259	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs775119859 CA6648604	259	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA385463714 rs7973381	262	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1594745250 COSM192339 CA385463718	263	G>E	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs574196970 COSM138886 CA6648606	263	G>R	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM1323137 CA6648608 rs201621277	265	R>Q	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA6648607 rs200444628	265	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200253557 CA385463755	268	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385463756 rs758378363	269	V>L		No	ClinGen ExAC gnomAD
CA6648610 rs758378363	269	V>M		No	ClinGen ExAC gnomAD
rs1332932674 CA385463773	271	H>R		No	ClinGen gnomAD
CA385463771 rs1412253333	271	H>Y		No	ClinGen gnomAD
CA6648616 rs547877619	272	W>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6648614 rs368789621	272	W>*		No	ClinGen ESP ExAC gnomAD
rs547877619 CA6648615 CA6648617	272	W>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368789621 CA6648613	272	W>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs368789621 CA385463780	272	W>S		No	ClinGen ESP ExAC gnomAD
rs1486673896 CA385463785	273	G>E		No	ClinGen TOPMed
rs770240474 CA385463781	273	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6648618 rs770240474	273	G>W		No	ClinGen ExAC TOPMed gnomAD
rs759448855	274	G>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA6648620 rs563340967	274	G>C	Bardet-biedl syndrome (bbs) [Ensembl]	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs563340967 CA6648619	274	G>S	Bardet-biedl syndrome (bbs) [Ensembl]	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759448855	275	C>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA6648622 rs774861127	275	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA237785636 rs569102560	278	E>D		No	ClinGen Ensembl
rs768066916 CA6648624	278	E>K		No	ClinGen ExAC gnomAD
rs776298132 CA6648625	278	E>V		No	ClinGen ExAC gnomAD
rs948970008 CA237785643	279	L>P		No	ClinGen Ensembl
TCGA novel	280	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1465714577 CA385463859	285	Q>H		No	ClinGen TOPMed gnomAD
TCGA novel	288	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6648626 rs761485628	289	V>M		No	ClinGen ExAC gnomAD
CA237785653 rs928625407	292	M>K		No	ClinGen Ensembl
CA385463932 rs1449223777	296	T>S		No	ClinGen gnomAD
CA6648629 rs374948623	298	E>K		No	ClinGen ESP ExAC gnomAD
CA385463943 rs374948623	298	E>Q		No	ClinGen ESP ExAC gnomAD
rs1476843535 CA385463958	300	P>S		No	ClinGen gnomAD
rs1476843535 CA385463959	300	P>T		No	ClinGen gnomAD
rs765329581 CA237785658	301	H>P		No	ClinGen Ensembl
rs766271134 CA237785665	301	H>Q		No	ClinGen ExAC gnomAD
CA237785657 rs1053141462	301	H>Y		No	ClinGen gnomAD
rs755035040 CA6648632	304	T>M		No	ClinGen ExAC TOPMed gnomAD
rs754128019 CA6648656	305	F>L		No	ClinGen ExAC gnomAD
rs376773615 CA6648657	307	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA385464814 rs376773615	307	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs779176901 CA6648658	308	C>G		No	ClinGen ExAC gnomAD
CA6648660 rs767216717	309	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs369128119 CA6648659	309	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	311	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6648662 rs144052713	311	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA385464890 rs1168996924	312	Y>H		No	ClinGen gnomAD
rs772799269 COSM3384536 CA6648664	314	R>C	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6648665 rs373249560	314	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM468710 CA385464933 rs373249560	314	R>L	kidney Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA6648667 rs774058977	316	E>K		No	ClinGen ExAC gnomAD
rs1594746365 CA385464987	317	N>T		No	ClinGen Ensembl
CA6648669 rs564027387 COSM1208280	320	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA385465052 rs1594746378	321	H>P		No	ClinGen Ensembl
COSM431580 rs764293116 CA6648672	323	R>W	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	325	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6648673 rs754075170	326	T>M		No	ClinGen ExAC TOPMed gnomAD
CA385465180 rs1423191974	328	E>Q		No	ClinGen gnomAD
CA237786477 rs1018269403	329	K>M		No	ClinGen Ensembl
rs765613579 CA6648675	331	Y>C		No	ClinGen ExAC gnomAD
rs774006233 CA6648676	332	M>I		No	ClinGen ExAC gnomAD
rs1162872976 CA385465291	332	M>R		No	ClinGen TOPMed
CA385465339 rs1443049195	334	E>V		No	ClinGen TOPMed
CA385465352 rs1427628204	335	H>Y		No	ClinGen gnomAD
rs913242901 CA237786513	336	E>Q		No	ClinGen TOPMed gnomAD
rs1466556322 CA385465408	337	G>V		No	ClinGen gnomAD
rs1452587369 CA385465439	339	S>G		No	ClinGen TOPMed gnomAD
CA237786525 rs779647343	339	S>T		No	ClinGen Ensembl
rs753096494 CA237786537	341	A>P		No	ClinGen TOPMed
rs201283310 CA237786540	343	S>I		No	ClinGen 1000Genomes gnomAD
CA385465533 rs201283310	343	S>N		No	ClinGen 1000Genomes gnomAD
rs200802561 CA6648680	345	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs200802561 CA6648681	345	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA6648682 rs748944886	345	A>V		No	ClinGen ExAC gnomAD
rs1357736300 CA385465617	347	D>H		No	ClinGen gnomAD
rs1460787785 CA385465642	348	R>*		No	ClinGen TOPMed gnomAD
CA385465650 rs745587766	348	R>P		No	ClinGen ExAC gnomAD
CA6648685 rs745587766	348	R>Q		No	ClinGen ExAC gnomAD
rs772010511 CA6648686	349	A>T		No	ClinGen ExAC gnomAD
rs1288588785 CA385465726	351	H>Q		No	ClinGen TOPMed
COSM459417 CA385465773 rs1447419974	354	R>W	cervix Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA6648687 rs775520299	358	N>H		No	ClinGen ExAC gnomAD
rs760726253 CA6648688	359	E>K		No	ClinGen ExAC TOPMed gnomAD
CA6648721 rs373770232	361	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs562388922 CA6648724	364	C>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1182931922 CA385466102	365	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs746732590 CA6648725	368	G>D		No	ClinGen ExAC TOPMed gnomAD
CA6648727 rs768582577	370	T>N		No	ClinGen ExAC gnomAD
rs768582577 CA6648726	370	T>S		No	ClinGen ExAC gnomAD
rs1415230750 CA385466184	371	K>E		No	ClinGen gnomAD
rs142822754 COSM1677113 CA6648729	372	R>C	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs142822754 CA237787014	372	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA237787043 rs913592640	372	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA385466276 rs1377756221	375	D>A		No	ClinGen gnomAD
rs1430036137 CA385466288	376	P>T		No	ClinGen gnomAD
CA237787046 rs774005775	378	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs759838377 CA6648734	380	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1381253752 COSM275303 CA385466376	380	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA237787061 rs761649230	382	H>D		No	ClinGen Ensembl
rs1206103248 CA385466457	386	V>A		No	ClinGen gnomAD
rs1206103248 CA385466456	386	V>G		No	ClinGen gnomAD
rs1289816548 CA385466450	386	V>M		No	ClinGen TOPMed
rs764631331 CA6648738	391	A>T		No	ClinGen ExAC TOPMed gnomAD
rs750013335 CA6648739	392	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA385466558 rs1332819968	394	T>I		No	ClinGen TOPMed
CA385466549 rs1238490848	394	T>P		No	ClinGen gnomAD
TCGA novel	394	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370035260 CA6648740	395	K>E		No	ClinGen ESP ExAC gnomAD
CA6648743 rs754780184	396	R>Q		No	ClinGen ExAC gnomAD
rs374429707 CA6648741	396	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA6648744 rs374433509	397	H>N		No	ClinGen ExAC gnomAD
rs1594747075 CA385466585	397	H>P		No	ClinGen Ensembl
rs374063272 CA6648745	398	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6648747 rs376293205	398	R>H		No	ClinGen ExAC TOPMed gnomAD
rs376293205 CA6648746	398	R>P		No	ClinGen ExAC TOPMed gnomAD
rs771013899 CA6648749	399	G>E		No	ClinGen ExAC gnomAD
CA6648748 rs749295894	399	G>R		No	ClinGen ExAC gnomAD
CA6648750 rs774512369	402	P>S		No	ClinGen ExAC gnomAD
CA237787150 rs772813225	403	L>M		No	ClinGen TOPMed gnomAD
rs1365637290 CA385466649	403	L>P		No	ClinGen gnomAD
rs772813225 CA237787145	403	L>V		No	ClinGen TOPMed gnomAD
CA385466657 rs1230414150	404	P>A		No	ClinGen gnomAD
COSM3688368 rs114543757 CA6648751 RCV000972851	405	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs925036184 CA237787155	405	R>W		No	ClinGen TOPMed gnomAD
CA385466672 rs1195244430	406	A>S		No	ClinGen gnomAD
rs76639319 CA237787156	409	I>L		No	ClinGen Ensembl
CA6648752 rs772293856	411	T>A		No	ClinGen ExAC gnomAD
rs775972834 CA6648753	414	P>L		No	ClinGen ExAC gnomAD
CA385466797 rs1202305900	416	R>M		No	ClinGen gnomAD
rs761075652 CA6648754	417	E>V		No	ClinGen ExAC gnomAD
CA385466820 rs777289743	418	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6648756 rs777289743	418	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6648755 rs564218374	418	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762501146 CA6648757	420	G>A		No	ClinGen ExAC gnomAD
TCGA novel	420	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6648758 rs200169408	421	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1184579144 CA385466858	422	P>T		No	ClinGen TOPMed
rs1272008775 CA385466868	423	I>V		No	ClinGen TOPMed
CA385466880 rs1172618277	424	R>W		No	ClinGen TOPMed gnomAD
CA385466913 rs1346897982	428	R>T		No	ClinGen TOPMed
rs878961758 CA237787184	431	V>M		No	ClinGen gnomAD
rs751225573 CA6648759	436	M>T		No	ClinGen ExAC TOPMed gnomAD
CA385467895 rs1347624463	440	P>Q		No	ClinGen gnomAD
rs1403117676 CA385467904	441	S>R		No	ClinGen gnomAD
rs1565600752 CA385467920	444	A>D		No	ClinGen Ensembl
CA6648774 rs777236611	444	A>T		No	ClinGen ExAC gnomAD
CA385467935 rs1241770121	446	S>*		No	ClinGen TOPMed gnomAD
rs368194993 CA6648775	450	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs765965806 CA6648776	453	S>C		No	ClinGen ExAC gnomAD
rs1316321490 CA385467983	453	S>P		No	ClinGen TOPMed
CA6648777 rs149950420	454	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1198007042 CA385467992	455	A>T		No	ClinGen gnomAD
rs1437303769 CA385467995	455	A>V		No	ClinGen gnomAD
CA385468001 rs1305707895	456	G>E		No	ClinGen gnomAD
rs1594748345 CA385468005	457	S>G		No	ClinGen Ensembl
CA6648781 rs760472253	458	A>P		No	ClinGen ExAC gnomAD
rs763911800 CA6648782	459	A>G		No	ClinGen ExAC gnomAD
rs1363221091 CA385468027	460	N>S		No	ClinGen TOPMed gnomAD
rs924034005 CA237788204	461	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs200730656 CA237788213	463	S>N		No	ClinGen 1000Genomes
CA385468060 rs1360086366	465	V>A		No	ClinGen TOPMed
rs1164792355 CA385468086	467	M>R		No	ClinGen gnomAD
rs1164792355 CA385468085	467	M>T		No	ClinGen gnomAD
CA385468111 rs1367624794	469	G>D		No	ClinGen gnomAD
rs1302817146 CA385468120	470	N>Y		No	ClinGen gnomAD
CA237788220 rs374392091	473	G>D		No	ClinGen ESP TOPMed gnomAD
CA6648785 rs757234675	475	T>I		No	ClinGen ExAC gnomAD
TCGA novel	477	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385468214 COSM1677114 rs1335695170	478	L>F	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
CA237788243 rs890425801	478	L>P		No	ClinGen TOPMed
rs1471801240 CA385468230	479	S>C		No	ClinGen TOPMed
rs778951240 CA6648786	485	P>L		No	ClinGen ExAC gnomAD
CA6648787 rs750584946	486	C>Y		No	ClinGen ExAC gnomAD
rs1221239451 CA385468356	487	I>M		No	ClinGen gnomAD
rs1274977868 CA385468370	488	A>V		No	ClinGen TOPMed gnomAD
CA6648788 rs368186732	489	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs780272131 CA6648789	490	T>A		No	ClinGen ExAC gnomAD
CA6648790 rs185679191	491	G>C		No	ClinGen 1000Genomes ExAC gnomAD
CA6648791 rs769033058	491	G>D		No	ClinGen ExAC gnomAD
rs185679191 CA385468399	491	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA385468437 rs1445951282	493	S>C		No	ClinGen TOPMed
rs12578516 CA237788281	495	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA6648795 rs139792497	496	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA6648796 rs759027001	496	R>H	Variant assessed as Somatic; 4.623e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs533875222 CA6648797	497	R>C		No	ClinGen ExAC gnomAD
CA6648798 rs775171324	497	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1396343650 CA385468497	498	L>I		No	ClinGen gnomAD
rs1397157719 CA385468537	501	L>V		No	ClinGen gnomAD
rs890152411 CA237788306	502	R>G		No	ClinGen Ensembl
CA6648799 rs760289179	502	R>K		No	ClinGen ExAC gnomAD
CA237788319 rs866686999	506	L>I		No	ClinGen Ensembl
rs147931475 CA6648804	510	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA6648805 rs147931475	510	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
RCV000960167 CA6648803 rs149817893	510	R>W		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs566564028 CA6648807	512	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs963099490 CA237788344	513	G>R		No	ClinGen TOPMed gnomAD
VAR_035558	514	T>I	a breast cancer sample; somatic mutation [UniProt]	No	UniProt
CA385468800 rs781683841	515	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6648809 rs781683841	515	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6648808 COSM1476779 rs375428680	515	R>W	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1565600997 CA385468806	516	G>C		No	ClinGen Ensembl
rs1168450436 CA385468878	520	P>A		No	ClinGen TOPMed
rs1372547639 CA385468882	520	P>L		No	ClinGen gnomAD
rs990717142 CA237788382	521	S>N		No	ClinGen TOPMed
rs1565601019 CA385468948	523	S>C		No	ClinGen Ensembl
rs756280054	525	T>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs774916232 CA6648815	526	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1440205364 CA385469112	526	G>V		No	ClinGen gnomAD
rs1314898459 CA385469153	528	T>I		No	ClinGen gnomAD
TCGA novel	529	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385469189 rs1487397766	530	S>F		No	ClinGen TOPMed
CA6648829 rs756509884	531	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6648830 rs147758271	531	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6648831 rs749783306	532	R>C		No	ClinGen ExAC gnomAD
rs200306754 CA6648832 COSM3398928	532	R>H	central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA6648833 rs779612265	533	V>M		No	ClinGen ExAC gnomAD
rs746451282 CA6648834	534	G>A		No	ClinGen ExAC
COSM144946 rs144673003 CA6648835	535	P>S	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA6648836 rs529336310	537	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6648837 rs747836770	538	S>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	539	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6648839 rs544591554	541	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1426197874 CA385469387	541	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs143462399 CA6648840	542	R>C		No	ClinGen ESP ExAC TOPMed
CA6648841 rs766159479	542	R>H		No	ClinGen ExAC TOPMed gnomAD
CA385469402 rs766159479	542	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6648842 rs766159479	542	R>P		No	ClinGen ExAC TOPMed gnomAD
CA385469468 rs1344298200	545	S>R		No	ClinGen gnomAD
CA237788757 rs372102723	546	S>C		No	ClinGen ESP gnomAD
rs200128720 CA6648844	549	I>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6648843 rs200128720	549	I>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200128720 CA6648845	549	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6648846 rs756456896	550	S>N		No	ClinGen ExAC gnomAD
TCGA novel	552	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1424981970 CA385469596	553	Y>C		No	ClinGen TOPMed
CA6648850 COSM3671145 rs201845227	557	R>C	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA6648851 rs746398371	557	R>H		No	ClinGen ExAC gnomAD
rs371089900 CA6648852	558	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs972690369 COSM942042 CA237788813	558	R>H	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs972690369 CA385469703	558	R>P		No	ClinGen TOPMed gnomAD
rs1029055257 CA237788816	559	S>P		No	ClinGen TOPMed
rs780728258 CA6648853	560	S>F		No	ClinGen ExAC gnomAD
CA385469800 rs1594749403	565	F>S		No	ClinGen Ensembl
rs747785448 CA6648854	566	P>A		No	ClinGen ExAC gnomAD
rs201050450 CA385469823	566	P>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201050450 CA385469826	566	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6648855 rs201050450	566	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368138761 CA6648858	567	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	567	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368138761 CA6648856	567	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368138761 CA6648857	567	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA385469856 rs1325105370	569	S>T		No	ClinGen TOPMed
rs1275055587 CA385469897	571	P>T		No	ClinGen TOPMed
COSM1208282 CA385469927 rs1409981398	572	E>D	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA6648860 rs759589302	572	E>Q		No	ClinGen ExAC gnomAD
rs566991727 CA385469959	574	G>A		No	ClinGen 1000Genomes ExAC gnomAD
rs267603605 COSM549256 CA237788852	574	G>R	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs566991727 CA6648861	574	G>V		No	ClinGen 1000Genomes ExAC gnomAD
CA6648862 rs775773783	575	A>T		No	ClinGen ExAC gnomAD
rs367578462 CA6648864	576	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA385469981 rs1565601582	576	S>P		No	ClinGen Ensembl
CA6648865 rs764155302	577	S>F		No	ClinGen ExAC TOPMed gnomAD
CA385470010 rs764155302	577	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA6648866 rs754106947	579	P>T		No	ClinGen ExAC TOPMed gnomAD
CA237788881 rs527900026	580	G>S		No	ClinGen gnomAD
CA6648867 rs200441300	582	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6648868 rs765668438	584	A>G		No	ClinGen ExAC
CA385470153 rs1464108125	585	Q>P		No	ClinGen TOPMed
CA237788886 rs750904883	587	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs750904883 CA6648869	587	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs199642258 CA6648872	590	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199642258 CA6648871	590	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758959112 CA6648870	590	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6648873 rs755663159	593	Y>C		No	ClinGen ExAC gnomAD
CA237788905 rs541715256	594	A>V		No	ClinGen gnomAD
CA6648874 rs777242040	596	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6648877 rs376908129	598	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs376908129 CA6648876	598	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA385470336 rs1183640785	598	G>R		No	ClinGen TOPMed
CA385470344 rs376908129	598	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
RCV001175556 rs758888293	599	G>missing		No	ClinVar dbSNP
CA385470352 rs1416740082	599	G>D		No	ClinGen gnomAD
rs1196728531 CA385470346	599	G>S		No	ClinGen TOPMed
CA6648878 rs147997893	600	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA385470358 rs147997893	600	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1199397071 CA385470365	600	G>V		No	ClinGen TOPMed
CA385470369 rs1337303625	601	T>A		No	ClinGen gnomAD
CA6648880 rs201538749	602	S>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1262154436 CA385470429	606	A>E		No	ClinGen TOPMed
rs1309131329 CA385470472	609	L>P		No	ClinGen TOPMed
rs1042660638 CA237788953	610	D>A		No	ClinGen TOPMed gnomAD
rs1042660638 CA237788954	610	D>G		No	ClinGen TOPMed gnomAD
CA385470480 rs1042660638	610	D>V		No	ClinGen TOPMed gnomAD
rs765569651 CA385470490	611	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6648886 rs765569651	611	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6648885 rs368078339	611	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs1202123173 CA385470546	616	P>L		No	ClinGen gnomAD
TCGA novel	616	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750849875 CA6648887	617	M>I		No	ClinGen ExAC gnomAD
CA237788955 rs915631630	617	M>L		No	ClinGen TOPMed
CA385470548 rs915631630	617	M>V		No	ClinGen TOPMed
rs766813817 CA6648889	618	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6648888 rs763307946	618	P>S		No	ClinGen ExAC
rs372578437 CA6648891	619	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6648890 rs368007733	619	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA385470584 rs1474754798	620	W>*		No	ClinGen gnomAD
rs375530514 CA6648892	622	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1238988 CA385470626 rs1594749795	623	R>*	oesophagus [Cosmic]	No	ClinGen cosmic curated Ensembl
CA6648893 rs753413155	623	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs370091854 CA6648896	624	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs756993955 CA6648895	624	A>P		No	ClinGen ExAC gnomAD
rs756993955 CA6648894	624	A>T		No	ClinGen ExAC gnomAD
rs1320531045 CA385470654	625	E>D		No	ClinGen gnomAD
CA6648898 rs768202810	625	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772925983 CA237788980	626	Y>H		No	ClinGen Ensembl
rs1011961312 CA237788986	628	G>V		No	ClinGen TOPMed
rs200861277 CA6648901	629	Y>C		No	ClinGen ESP ExAC TOPMed
rs747001298 CA6648899	629	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs140787723 CA6648903 COSM74756	632	N>K	ovary [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs906720694 CA237788996	632	N>S		No	ClinGen Ensembl
rs555698950 CA6648904	633	A>V		No	ClinGen 1000Genomes ExAC
rs1359000505 CA385470763	634	G>R		No	ClinGen TOPMed
rs1594749920 CA385470779	635	V>G		No	ClinGen Ensembl
CA385470792 rs1263121069	636	T>I		No	ClinGen gnomAD
rs538595523 COSM74757 CA6648908	637	R>Q	ovary endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA6648907 rs200606293	637	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385470838 rs1192194289	640	S>T		No	ClinGen Ensembl
TCGA novel	641	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6648910 rs763500947	641	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA6648911 rs753456662	642	P>S		No	ClinGen ExAC gnomAD
rs756725183 CA6648912	648	R>C		No	ClinGen ExAC gnomAD
COSM1736472 CA6648913 rs367789336	648	R>H	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1414375643 CA385470979	651	P>Q		No	ClinGen TOPMed
CA385471046 rs1419295145	657	F>V		No	ClinGen gnomAD
CA385471072 CA6648916 rs374770255	658	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA385471074 rs1367515244	659	S>R		No	ClinGen gnomAD
CA6648918 rs755006681	661	G>S		No	ClinGen ExAC gnomAD
CA385471112 rs1336880663	662	C>S		No	ClinGen TOPMed gnomAD
CA6648920 rs748196652	663	V>A		No	ClinGen ExAC gnomAD
rs780992909 CA6648919	663	V>I		No	ClinGen ExAC gnomAD
rs1018123186 CA237789083	664	H>R		No	ClinGen TOPMed gnomAD
CA6648922 rs150127797	664	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA6648925 rs572181120	666	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs572181120 CA385471161	666	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1420836393 CA385471173	667	P>T		No	ClinGen gnomAD
rs775875244 CA6648928	668	T>I		No	ClinGen ExAC TOPMed gnomAD
CA6648927 rs768002671	668	T>P		No	ClinGen ExAC gnomAD
rs138680284 CA6648929	670	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1460485464 CA385471218	671	G>R		No	ClinGen gnomAD
CA237789117 rs961821733	672	G>A		No	ClinGen TOPMed
CA6648931 rs750072514	672	G>R		No	ClinGen ExAC TOPMed gnomAD
rs766080250 CA6648933	673	G>V		No	ClinGen ExAC gnomAD
TCGA novel	674	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA237789121 rs200775132	676	F>C		No	ClinGen 1000Genomes
CA385471331 rs1594750151	679	Y>S		No	ClinGen Ensembl
rs1166115603 CA385471337	680	L>I		No	ClinGen TOPMed gnomAD
CA237789124 rs974867444	681	P>L		No	ClinGen TOPMed gnomAD
rs1594750178 CA385471360	682	T>P		No	ClinGen Ensembl
rs1376612340 CA385471417	686	S>L		No	ClinGen gnomAD
rs555605009 CA6648939	687	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA6648940 rs555605009	687	P>T		No	ClinGen 1000Genomes ExAC gnomAD
CA385471429 rs1356844630	688	Q>*		No	ClinGen gnomAD
rs771211991 CA6648941	688	Q>P		No	ClinGen ExAC gnomAD
CA385471442 rs971887652	689	P>H		No	ClinGen TOPMed gnomAD
rs971887652 CA237789146	689	P>L		No	ClinGen TOPMed gnomAD
CA385471452 rs1193988375	690	P>H		No	ClinGen gnomAD
CA6648942 rs779008962	690	P>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	692	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1185213050 CA385471584	696	A>V		No	ClinGen gnomAD
TCGA novel	698	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385471619 rs1164399469	698	M>T		No	ClinGen gnomAD
CA237789158 rs11553626	701	R>G		No	ClinGen Ensembl
CA6648946 rs372465556	701	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA237789189 rs920472026	704	Q>*		No	ClinGen Ensembl
CA385471801 rs1255413507	706	E>K		No	ClinGen TOPMed
CA6648949 rs762554021	707	P>L		No	ClinGen ExAC gnomAD
rs765994366 CA6648950	709	V>A		No	ClinGen ExAC gnomAD
CA385471863 rs1339134061	709	V>F		No	ClinGen gnomAD
rs1339134061 CA385471861	709	V>L		No	ClinGen gnomAD
rs141789719 CA6648951	710	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA385471913 rs1295917661	712	S>F		No	ClinGen gnomAD
CA237789228 rs915604014	713	M>T		No	ClinGen TOPMed gnomAD
rs1450320226 CA385471967	715	G>S		No	ClinGen TOPMed
rs949814444 CA385471987	716	S>C		No	ClinGen TOPMed
rs949814444 CA237789230	716	S>R		No	ClinGen TOPMed
CA6648953 rs767254882	720	P>T		No	ClinGen ExAC gnomAD
TCGA novel	721	Y>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1276506226 CA385472125	722	M>I		No	ClinGen TOPMed
rs756100571 CA6648955	724	F>L		No	ClinGen ExAC TOPMed gnomAD
CA385472239 rs1241006818	727	T>I		No	ClinGen gnomAD
CA385472259 rs1368023221	728	D>E		No	ClinGen TOPMed
rs1434036639 CA385472271	729	T>N		No	ClinGen TOPMed
CA385472358 rs1402320978	734	G>E		No	ClinGen TOPMed
rs1331986744 CA385472366	735	P>S		No	ClinGen TOPMed
CA385472401 rs1181484660	736	E>D		No	ClinGen gnomAD
rs1430318516 CA385472462	739	A>G		No	ClinGen gnomAD
rs757297667 CA6648958	742	P>H		No	ClinGen ExAC gnomAD
CA6648957 rs753849741	742	P>S		No	ClinGen ExAC gnomAD
rs753849741 CA385472516	742	P>T		No	ClinGen ExAC gnomAD
rs1397557620 CA385472565	745	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs138157845 COSM3384538 CA6648960	745	A>V	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1465909682 CA385472596	746	R>K		No	ClinGen TOPMed gnomAD
rs1465909682 CA385472589	746	R>T		No	ClinGen TOPMed gnomAD
rs1224563422 CA385472616	747	G>D		No	ClinGen TOPMed gnomAD
CA237789249 rs924399161	749	G>D		No	ClinGen Ensembl
CA6648963 rs747509020	752	P>A		No	ClinGen ExAC gnomAD
rs868283139 CA237789261	752	P>L		No	ClinGen Ensembl
CA6648964 rs769216016	753	L>F		No	ClinGen ExAC gnomAD
CA6648965 rs777287963	753	L>P		No	ClinGen ExAC gnomAD
rs377236422 CA6648966	754	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6648967 rs370486201	755	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1565602524 CA385472743	758	P>T		No	ClinGen Ensembl
TCGA novel	759	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759160451 CA6648969	762	G>D		No	ClinGen ExAC gnomAD
rs759160451 CA6648970	762	G>V		No	ClinGen ExAC gnomAD
CA385472898 rs1191551029	765	P>L		No	ClinGen gnomAD
CA237789296 rs201271317	766	C>R		No	ClinGen 1000Genomes TOPMed
rs752553799 CA6648971	767	P>T		No	ClinGen ExAC gnomAD
rs1011202054 CA237789299	769	Q>E		No	ClinGen Ensembl
CA6648973 rs763963114	771	S>L		No	ClinGen ExAC TOPMed gnomAD
CA385472996 rs1160315310	772	Y>N		No	ClinGen gnomAD
CA6648976 rs200374961	775	P>A		No	ClinGen 1000Genomes ExAC gnomAD
CA385473071 rs1365646325	777	Q>K		No	ClinGen gnomAD
rs750640199 CA6648977	777	Q>P		No	ClinGen ExAC gnomAD
CA385473113 rs1187351940	779	T>I		No	ClinGen gnomAD
CA6648978 rs758609027	781	G>S		No	ClinGen ExAC gnomAD
CA6648979 rs780426081	781	G>V		No	ClinGen ExAC TOPMed gnomAD
CA237789340 rs778898048	785	S>F		No	ClinGen gnomAD
CA385473183 rs1308922331	785	S>P		No	ClinGen gnomAD
CA385473201 rs1594750714	786	H>P		No	ClinGen Ensembl
CA237789341 rs890755485	786	H>Q		No	ClinGen TOPMed
rs755412722 CA6648981	789	L>R		No	ClinGen ExAC gnomAD
CA6648982 rs781748757	794	K>T		No	ClinGen ExAC gnomAD
rs1224828144 CA385473315	795	A>P		No	ClinGen TOPMed gnomAD
rs1352740229 CA385473335	796	L>P		No	ClinGen Ensembl
rs748704866 CA6648983	797	G>S		No	ClinGen ExAC TOPMed gnomAD
CA385473366 rs1478005717	799	T>S		No	ClinGen gnomAD
rs74473582 CA237789351	800	Y>H		No	ClinGen gnomAD
CA385473393 rs1358164612	801	S>N		No	ClinGen TOPMed
CA385473442 rs1264071704	804	P>S		No	ClinGen TOPMed gnomAD
rs1050431269 CA237789353	805	R>*		No	ClinGen gnomAD
rs376640247 CA6648984	805	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	807	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6648985 rs773789139	808	H>D		No	ClinGen ExAC gnomAD
rs773789139 CA385473494	808	H>Y		No	ClinGen ExAC gnomAD
CA6648986 rs745528986	810	G>V		No	ClinGen ExAC gnomAD
rs1179799404 CA385473554	812	V>A		No	ClinGen TOPMed
CA6648987 rs771559868	812	V>M		No	ClinGen ExAC gnomAD
rs889144124 CA237789361	813	Q>P		No	ClinGen TOPMed gnomAD
rs775139874 CA6648988	816	P>L		No	ClinGen ExAC gnomAD
VAR_035559	817	E>Q	a breast cancer sample; somatic mutation [UniProt]	No	UniProt
rs112209004 CA237789373	819	G>E		No	ClinGen TOPMed gnomAD
CA6648989 rs760414385	819	G>R		No	ClinGen ExAC gnomAD
rs112209004 CA385473634	819	G>V		No	ClinGen TOPMed gnomAD
rs1299872008 CA385473638	820	C>Y		No	ClinGen gnomAD
rs763909577 CA6648990	821	P>T		No	ClinGen ExAC gnomAD
rs149553839 CA6648992	823	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA237789385 rs993256018	824	S>C		No	ClinGen Ensembl
CA6648993 rs765349183	827	T>I		No	ClinGen ExAC gnomAD
CA6648995 rs148731765	831	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6648996 rs766657731	832	C>Y		No	ClinGen ExAC gnomAD
rs751857353 CA6648997	834	N>S		No	ClinGen ExAC TOPMed gnomAD
CA385474584 rs1351358957	836	H>D		No	ClinGen TOPMed
rs1594750946 CA385474587	836	H>P		No	ClinGen Ensembl
rs1022618991 CA237791211	836	H>Q		No	ClinGen TOPMed gnomAD
CA385474600 rs1412421207	837	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs758320112 CA237791220	838	S>T		No	ClinGen Ensembl
rs371534575 CA6648998	839	E>K		No	ClinGen ESP ExAC gnomAD
CA385474638 rs1396082920	840	G>R		No	ClinGen TOPMed
CA6649000 rs748674893	841	P>L		No	ClinGen ExAC gnomAD
rs1398037874 CA385474655	841	P>S		No	ClinGen gnomAD
rs1398037874 CA385474651	841	P>T		No	ClinGen gnomAD
CA385474663 rs61734542	842	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778346951 CA6649002	842	P>L		No	ClinGen ExAC gnomAD
CA6649001 rs61734542	842	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385474673 rs1454760110	843	H>Y		No	ClinGen gnomAD
rs745312143 CA6649003	844	P>S		No	ClinGen ExAC gnomAD
CA385474720 rs1363551405	846	P>L		No	ClinGen gnomAD
rs771594350 CA6649004	846	P>S		No	ClinGen ExAC gnomAD
CA385474739 rs1275653248	848	F>Y		No	ClinGen gnomAD
CA385474756 rs1198368567	849	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs775084642 CA6649005	849	S>P		No	ClinGen ExAC TOPMed gnomAD
rs746704993 CA6649006	850	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA6649008 rs768421030 COSM265261	851	Y>*	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA385474785 rs1594751051	851	Y>S		No	ClinGen Ensembl
rs1236536860 CA385474795	852	P>A		No	ClinGen gnomAD
CA385474803 rs1475421218	852	P>L		No	ClinGen gnomAD
CA237791303 rs923953698	853	Q>E		No	ClinGen TOPMed
rs1178054958 CA385474821	854	P>A		No	ClinGen TOPMed
rs1178054958 CA385474819	854	P>T		No	ClinGen TOPMed
TCGA novel	860	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762897107 CA6649012	862	S>L		No	ClinGen ExAC gnomAD
TCGA novel	863	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385474958 rs1412611763	864	P>L		No	ClinGen gnomAD
CA385474951 rs1408010708	864	P>S		No	ClinGen gnomAD
CA385474968 rs1372410554	865	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1594751175 CA385474974	866	T>P		No	ClinGen Ensembl
TCGA novel	867	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385475005 rs1215558059	868	P>S		No	ClinGen TOPMed
rs375975477 CA6649014	869	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs759894568 CA6649015	869	P>H		No	ClinGen ExAC TOPMed gnomAD
rs375975477 CA385475016	869	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6649016 rs564746380	870	P>A		No	ClinGen ExAC gnomAD
rs1565603031	870	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA6649017 rs564746380	870	P>T		No	ClinGen ExAC gnomAD
rs1199105605 CA385475084	875	S>A		No	ClinGen gnomAD
CA385475092 rs1277411648	876	E>G		No	ClinGen gnomAD
rs1309887873 CA385475101	877	P>L		No	ClinGen TOPMed
rs1219939562 CA385475113	879	P>L		No	ClinGen TOPMed
CA6649019 rs778095108	881	L>V		No	ClinGen ExAC gnomAD
rs1565603075 CA385475136	883	F>L		No	ClinGen Ensembl
VAR_015114	884	D>A		No	UniProt
CA6649021 rs142356674	884	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs754400912 CA6649020	884	D>G		No	ClinGen ExAC TOPMed gnomAD
CA385475154 rs1399761461	885	S>F		No	ClinGen TOPMed
CA6649023 rs746655729	888	H>D		No	ClinGen ExAC gnomAD
CA6649024 rs768365951	891	G>A		No	ClinGen ExAC gnomAD
TCGA novel	891	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6649025 rs780905505	893	L>F		No	ClinGen ExAC gnomAD
CA6649026 rs747845466	893	L>P		No	ClinGen ExAC TOPMed gnomAD
CA385475199 rs780905505	893	L>V		No	ClinGen ExAC gnomAD
CA385475215 rs1349827041	895	A>V		No	ClinGen TOPMed
rs777734120 CA6649028	896	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs763029899 CA6649029	897	L>V		No	ClinGen ExAC TOPMed gnomAD
CA6649030 rs147494642	898	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs147494642 CA385475229	898	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA385475234 rs1231469327	899	C>S		No	ClinGen gnomAD
rs201832885 CA6649033	901	Y>*		No	ClinGen ExAC gnomAD
CA6649031 rs774638929	901	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA385475252 rs1274597002	901	Y>D		No	ClinGen gnomAD
CA385475258 rs1283519778	902	V>I		No	ClinGen gnomAD
TCGA novel	903	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6649035 COSM3812662 rs760909851	905	Q>E	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs764559524 CA6649036	906	Q>*		No	ClinGen ExAC gnomAD
CA6649037 rs754279016	907	E>A		No	ClinGen ExAC gnomAD
TCGA novel	907	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754279016 CA385475294	907	E>V		No	ClinGen ExAC gnomAD
CA237791445 rs371696253	908	L>P		No	ClinGen Ensembl
CA385475321 rs1364142518	911	E>D		No	ClinGen gnomAD
CA385475324 rs1253674081	912	G>R		No	ClinGen gnomAD
CA385475331 rs1269271138	913	G>E		No	ClinGen TOPMed
rs757823205 CA6649038	913	G>R		No	ClinGen ExAC
rs779539699 CA6649039	914	G>S		No	ClinGen ExAC TOPMed gnomAD
rs201302136 CA6649040	918	A>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1488078943 CA385475362	918	A>S		No	ClinGen TOPMed
rs201302136 CA237791450	918	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1393016876 CA385475369	919	P>L		No	ClinGen gnomAD
CA6649041 rs754500775	919	P>S		No	ClinGen ExAC
TCGA novel	920	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368469814 CA6649044	920	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6649045 rs777679896	921	Q>R		No	ClinGen ExAC gnomAD
rs749232881 CA6649046	922	E>A		No	ClinGen ExAC gnomAD
CA385475400 rs1565603289	924	S>C		No	ClinGen Ensembl
CA385475421 rs1303794084	927	S>T		No	ClinGen TOPMed
CA385475434 rs1306560005	929	K>*		No	ClinGen gnomAD
TCGA novel	930	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1051088256 CA237791491	930	F>Y		No	ClinGen TOPMed
rs1246021821 CA385475452	932	G>R		No	ClinGen gnomAD
rs2228224 CA6649048 VAR_015115	933	G>D		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	933	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385475462 rs2228224	933	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1353712383 CA385475486	937	S>N		No	ClinGen gnomAD
CA385475493 rs1209154299	938	P>S		No	ClinGen gnomAD
rs536075646 CA6649050	940	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA6649051 rs145582008	940	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs536075646 CA6649049	940	R>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1594751574 CA385475510	941	A>T		No	ClinGen Ensembl
CA6649052 rs775544248	943	A>S		No	ClinGen ExAC gnomAD
CA6649053 rs147740622	943	A>V		No	ClinGen ESP ExAC TOPMed
CA385475531 rs1565603366	944	P>L		No	ClinGen Ensembl
CA385475532 rs1439280977	945	V>M		No	ClinGen gnomAD
TCGA novel	947	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs554710046 CA6649055	948	Y>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1370254161 CA385475559	949	G>R		No	ClinGen gnomAD
CA385475564 rs1456515400	949	G>V		No	ClinGen gnomAD
CA385475569 rs1594751640	950	P>R		No	ClinGen Ensembl
CA6649056 rs770718402	951	G>A		No	ClinGen ExAC TOPMed gnomAD
CA385475574 rs770718402	951	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1594751650 CA385475584	953	G>R		No	ClinGen Ensembl
rs765678067 CA6649057	961	S>L		No	ClinGen ExAC gnomAD
CA385475646 rs1449397447	962	G>S		No	ClinGen TOPMed gnomAD
CA237791564 rs866379238	963	S>P		No	ClinGen Ensembl
rs750955978 CA6649058	967	P>S		No	ClinGen ExAC gnomAD
TCGA novel	968	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385475696 rs1314505880	970	C>R		No	ClinGen gnomAD
CA385475713 rs1451174384	972	E>G		No	ClinGen gnomAD
CA237791615 rs867901056	972	E>K		No	ClinGen Ensembl
TCGA novel	973	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385475745 rs1243442634	977	G>R		No	ClinGen gnomAD
TCGA novel	978	A>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385475751 rs1251765243	978	A>T		No	ClinGen TOPMed gnomAD
rs1319949591 CA385475777	981	A>V		No	ClinGen gnomAD
CA6649061 rs752275003	982	S>L		No	ClinGen ExAC TOPMed gnomAD
CA385475783 rs1257165110	983	H>N		No	ClinGen gnomAD
CA385475786 rs1461647143	983	H>P		No	ClinGen gnomAD
rs1461647143 CA385475787	983	H>R		No	ClinGen gnomAD
rs1394608554 CA385475800	985	A>S		No	ClinGen gnomAD
TCGA novel	985	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385475828 rs1184432538	990	R>*		No	ClinGen gnomAD
rs370413110 CA6649062	990	R>Q		No	ClinGen ESP ExAC gnomAD
CA385475847 rs1442415390	993	P>L		No	ClinGen gnomAD
rs777293425 CA6649063	994	P>S		No	ClinGen ExAC TOPMed gnomAD
rs757139167 CA385475857	995	L>*		No	ClinGen ExAC gnomAD
rs757139167 CA6649065	995	L>S		No	ClinGen ExAC gnomAD
rs1467617601 CA385475864	996	P>R		No	ClinGen gnomAD
rs778954777 CA6649066	999	Y>*		No	ClinGen ExAC gnomAD
TCGA novel	999	Y>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385475893 rs1470547300	1001	P>T		No	ClinGen gnomAD
rs1301885056 CA385475921	1005	G>*		No	ClinGen gnomAD
rs772024116 CA6649068	1005	G>V		No	ClinGen ExAC gnomAD
CA385475926 rs1295636010	1006	G>D		No	ClinGen gnomAD
rs775698948 CA6649069	1006	G>S		No	ClinGen ExAC gnomAD
CA237791686 rs61739569	1011	C>R		No	ClinGen Ensembl
RCV000953667 CA6649070 VAR_052723 rs2229300	1012	G>V		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1216707027 CA385475979	1014	P>S		No	ClinGen gnomAD
rs1224740711 CA385476009	1018	R>S		No	ClinGen TOPMed gnomAD
CA6649072 rs776855654	1019	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1257932005 CA385476023	1021	G>E		No	ClinGen gnomAD
rs1482417398 CA385476031	1022	G>V		No	ClinGen gnomAD
TCGA novel	1022	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762119826 CA6649073	1026	Y>H		No	ClinGen ExAC gnomAD
CA385476053 rs1594752030	1026	Y>S		No	ClinGen Ensembl
CA6649074 rs765626709	1027	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6649075 rs773683435	1028	P>L		No	ClinGen ExAC gnomAD
CA6649076 rs773683435	1028	P>R		No	ClinGen ExAC gnomAD
CA237791746 rs1027428919	1030	E>K		No	ClinGen gnomAD
CA237791754 rs887643010	1031	G>A		No	ClinGen Ensembl
rs1480937061 CA385476097	1033	V>A		No	ClinGen gnomAD
CA385476099 rs1357823068	1034	C>S		No	ClinGen gnomAD
CA6649079 rs755592734	1034	C>Y		No	ClinGen ExAC gnomAD
CA6649080 rs763752118	1036	P>T		No	ClinGen ExAC TOPMed gnomAD
CA6649084 rs778903349	1044	N>D		No	ClinGen ExAC gnomAD
CA6649085 rs745789152	1044	N>K		No	ClinGen ExAC gnomAD
CA6649086 rs758432160	1046	Q>E		No	ClinGen ExAC gnomAD
CA6649087 rs779862855	1048	D>N		No	ClinGen ExAC TOPMed gnomAD
CA385476378 rs1263043549	1054	D>V		No	ClinGen gnomAD
CA237791816 rs578089149	1057	Q>R		No	ClinGen 1000Genomes TOPMed gnomAD
CA6649092 rs748413929	1062	P>S		No	ClinGen ExAC gnomAD
CA6649093 rs770128594	1064	S>C		No	ClinGen ExAC gnomAD
rs770128594 CA6649094	1064	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA385476529 rs1237502199	1064	S>P		No	ClinGen TOPMed
rs371558176 CA6649095	1066	D>H		No	ClinGen ESP ExAC gnomAD
rs1565604047 CA385476552	1067	Q>*		No	ClinGen Ensembl
CA6649098 rs144893788	1068	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6649097 rs144893788	1068	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6649096 rs149870317 RCV000932082	1068	R>W		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1256380503 CA385476575	1069	G>D		No	ClinGen TOPMed
rs761617989 CA6649101	1070	S>G		No	ClinGen ExAC gnomAD
TCGA novel	1070	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA237791870 rs916865788	1070	S>T		No	ClinGen TOPMed
CA6649102 rs765120932	1072	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1278558735 CA385476617	1073	H>Y		No	ClinGen TOPMed
rs149048217 CA6649103	1074	T>N		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs1594752465 CA385476629	1074	T>P		No	ClinGen Ensembl
CA6649104 rs149048217	1074	T>S		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs751486798 CA385476663	1076	P>H		No	ClinGen ExAC TOPMed gnomAD
CA6649106 rs751486798	1076	P>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1076	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs144663837 CA6649107	1077	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs781302385 CA6649108	1079	G>E		No	ClinGen ExAC gnomAD
CA385476710 rs748362709	1081	P>L		No	ClinGen ExAC gnomAD
CA6649109 rs748362709	1081	P>R		No	ClinGen ExAC gnomAD
CA385476720 rs1239576042	1082	N>S		No	ClinGen gnomAD
CA385476718 rs1239576042	1082	N>T		No	ClinGen gnomAD
CA385476743 rs1342384762	1083	M>I		No	ClinGen TOPMed
CA385476806 rs1437404075	1088	M>T		No	ClinGen gnomAD
CA6649110 rs769935841	1089	S>T		No	ClinGen ExAC gnomAD
CA6649112 rs749615188	1090	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6649113 rs771230727	1091	L>F		No	ClinGen ExAC gnomAD
CA237791940 COSM24658 rs267603606	1094	S>F	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs561194556 CA6649114	1096	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA6649116 rs768270155	1097	G>A		No	ClinGen ExAC TOPMed gnomAD
rs1368596205 CA385476938	1098	E>G		No	ClinGen TOPMed
VAR_015116 rs2228226 CA6649119	1100	E>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA385477033 rs1488849799	1105	S>G		No	ClinGen TOPMed
rs914337244 CA237791987	1105	S>N		No	ClinGen TOPMed
CA6649121 rs764926851	1106	A>D		No	ClinGen ExAC
rs1409856982 CA385477046	1106	A>T		No	ClinGen TOPMed gnomAD

2 associated diseases with P08151

[MIM: 618123]: Polydactyly, postaxial, A8 (PAPA8)

A form of postaxial polydactyly, a condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal. PAPA8 is an autosomal recessive condition characterized by the presence of postaxial extra digits (hexadactyly) on the hands and/or the feet. {ECO:0000269|PubMed:28973407}. Note=The disease is caused by variants affecting the gene represented in this entry.

[MIM: 174400]: Polydactyly, preaxial 1 (PPD1)

A form of polydactyly, a condition defined by the occurrence of supernumerary digits in the upper and/or lower extremities. Preaxial or radial polydactyly refers to the presence of extra digits on the radial side of the hand. PPD1 is an autosomal recessive form characterized by duplication of the distal phalanx of the thumb. {ECO:0000269|PubMed:30620395}. Note=The disease may be caused by variants affecting the gene represented in this entry.

Without disease ID

A form of postaxial polydactyly, a condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal. PAPA8 is an autosomal recessive condition characterized by the presence of postaxial extra digits (hexadactyly) on the hands and/or the feet. {ECO:0000269|PubMed:28973407}. Note=The disease is caused by variants affecting the gene represented in this entry.
A form of polydactyly, a condition defined by the occurrence of supernumerary digits in the upper and/or lower extremities. Preaxial or radial polydactyly refers to the presence of extra digits on the radial side of the hand. PPD1 is an autosomal recessive form characterized by duplication of the distal phalanx of the thumb. {ECO:0000269|PubMed:30620395}. Note=The disease may be caused by variants affecting the gene represented in this entry.

5 regional properties for P08151

Type	Name	Position	InterPro Accession
domain	Zinc finger C2H2-type	235 - 267	IPR013087-1
domain	Zinc finger C2H2-type	268 - 300	IPR013087-2
domain	Zinc finger C2H2-type	301 - 330	IPR013087-3
domain	Zinc finger C2H2-type	331 - 361	IPR013087-4
domain	Zinc finger C2H2-type	362 - 392	IPR013087-5

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Tethered in the cytoplasm by binding to SUFU (PubMed:10806483) Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483) Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745) Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
axoneme	The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
ciliary base	Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
ciliary tip	Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GLI-SUFU complex	A protein repressing GLI's transcription factor activity when SMO signalling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

10 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding	Binding to a metal ion.
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
sequence-specific DNA binding	Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

30 GO annotations of biological process

Name	Definition
cerebellar cortex morphogenesis	The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
digestive tract morphogenesis	The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.
dorsal/ventral pattern formation	The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
epidermal cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.
liver regeneration	The regrowth of lost or destroyed liver.
lung development	The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
negative regulation of canonical Wnt signaling pathway	Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
negative regulation of hh target transcription factor activity	Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling.
notochord regression	The developmental process in which the stucture of the notochord is destroyed in an embryo.
osteoblast differentiation	The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
pituitary gland development	The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.
positive regulation of cardiac muscle cell proliferation	Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
positive regulation of cell cycle G1/S phase transition	Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of DNA replication	Any process that activates or increases the frequency, rate or extent of DNA replication.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of smoothened signaling pathway	Any process that activates or increases the frequency, rate or extent of smoothened signaling.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
prostate gland development	The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.
proximal/distal pattern formation	The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).
regulation of hepatocyte proliferation	Any process that modulates the frequency, rate or extent of hepatocyte proliferation.
regulation of osteoblast differentiation	Any process that modulates the frequency, rate or extent of osteoblast differentiation.
regulation of smoothened signaling pathway	Any process that modulates the frequency, rate or extent of smoothened signaling.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to wounding	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
smoothened signaling pathway	The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells.
spermatid development	The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
ventral midline development	The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate.

177 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q08DS3	OSR1	Protein odd-skipped-related 1	Bos taurus (Bovine)	PR
Q2VWH6	FEZF2	Fez family zinc finger protein 2	Bos taurus (Bovine)	PR
A6QNZ0	ZSCAN26	Zinc finger and SCAN domain-containing protein 26	Bos taurus (Bovine)	PR
A7MBI1	ZFP69	Zinc finger protein 69 homolog	Bos taurus (Bovine)	PR
Q08705	CTCF	Transcriptional repressor CTCF	Gallus gallus (Chicken)	PR
O42409	GFI1B	Zinc finger protein Gfi-1b	Gallus gallus (Chicken)	PR
A2T6W2	ZNF449	Zinc finger protein 449	Pan troglodytes (Chimpanzee)	PR
Q9U405	grau	Transcription factor grauzone	Drosophila melanogaster (Fruit fly)	PR
Q7K0S9	sug	Zinc finger protein GLIS2 homolog	Drosophila melanogaster (Fruit fly)	PR
P20385	Cf2	Chorion transcription factor Cf2	Drosophila melanogaster (Fruit fly)	PR
Q86P48	ATbp	AT-rich binding protein	Drosophila melanogaster (Fruit fly)	PR
P28698	MZF1	Myeloid zinc finger 1	Homo sapiens (Human)	PR
Q9NTW7	ZFP64	Zinc finger protein 64	Homo sapiens (Human)	PR
O14978	ZNF263	Zinc finger protein 263	Homo sapiens (Human)	PR
O60304	ZNF500	Zinc finger protein 500	Homo sapiens (Human)	PR
Q9UFB7	ZBTB47	Zinc finger and BTB domain-containing protein 47	Homo sapiens (Human)	PR
P18146	EGR1	Early growth response protein 1	Homo sapiens (Human)	PR
Q9Y5W3	KLF2	Krueppel-like factor 2	Homo sapiens (Human)	PR
Q9UNY5	ZNF232	Zinc finger protein 232	Homo sapiens (Human)	PR
Q96SZ4	ZSCAN10	Zinc finger and SCAN domain-containing protein 10	Homo sapiens (Human)	PR
P17028	ZNF24	Zinc finger protein 24	Homo sapiens (Human)	PR
P57682	KLF3	Krueppel-like factor 3	Homo sapiens (Human)	PR
P25490	YY1	Transcriptional repressor protein YY1	Homo sapiens (Human)	SS
O43296	ZNF264	Zinc finger protein 264	Homo sapiens (Human)	PR
P49711	CTCF	Transcriptional repressor CTCF	Homo sapiens (Human)	PR
Q9NQX1	PRDM5	PR domain zinc finger protein 5	Homo sapiens (Human)	PR
Q9HBE1	PATZ1	POZ-, AT hook-, and zinc finger-containing protein 1	Homo sapiens (Human)	PR
Q8TAX0	OSR1	Protein odd-skipped-related 1	Homo sapiens (Human)	PR
Q9UL58	ZNF215	Zinc finger protein 215	Homo sapiens (Human)	PR
Q8TBJ5	FEZF2	Fez family zinc finger protein 2	Homo sapiens (Human)	PR
Q96SR6	ZNF382	Zinc finger protein 382	Homo sapiens (Human)	PR
Q96IT1	ZNF496	Zinc finger protein 496	Homo sapiens (Human)	PR
Q96N95	ZNF396	Zinc finger protein 396	Homo sapiens (Human)	PR
Q9ULJ3	ZBTB21	Zinc finger and BTB domain-containing protein 21	Homo sapiens (Human)	PR
O75840	KLF7	Krueppel-like factor 7	Homo sapiens (Human)	PR
Q9H9D4	ZNF408	Zinc finger protein 408	Homo sapiens (Human)	PR
Q13127	REST	RE1-silencing transcription factor	Homo sapiens (Human)	PR
Q8IZM8	ZNF654	Zinc finger protein 654	Homo sapiens (Human)	PR
Q14526	HIC1	Hypermethylated in cancer 1 protein	Homo sapiens (Human)	PR
P17022	ZNF18	Zinc finger protein 18	Homo sapiens (Human)	PR
Q86XF7	ZNF575	Zinc finger protein 575	Homo sapiens (Human)	PR
Q06889	EGR3	Early growth response protein 3	Homo sapiens (Human)	PR
Q8NAM6	ZSCAN4	Zinc finger and SCAN domain-containing protein 4	Homo sapiens (Human)	PR
Q08ER8	ZNF543	Zinc finger protein 543	Homo sapiens (Human)	PR
P17029	ZKSCAN1	Zinc finger protein with KRAB and SCAN domains 1	Homo sapiens (Human)	PR
Q8N680	ZBTB2	Zinc finger and BTB domain-containing protein 2	Homo sapiens (Human)	PR
O95625	ZBTB11	Zinc finger and BTB domain-containing protein 11	Homo sapiens (Human)	PR
Q9NPC7	MYNN	Myoneurin	Homo sapiens (Human)	PR
Q96BV0	ZNF775	Zinc finger protein 775	Homo sapiens (Human)	PR
Q8NF99	ZNF397	Zinc finger protein 397	Homo sapiens (Human)	PR
Q63HK3	ZKSCAN2	Zinc finger protein with KRAB and SCAN domains 2	Homo sapiens (Human)	PR
Q5FWF6	ZNF789	Zinc finger protein 789	Homo sapiens (Human)	PR
Q15776	ZKSCAN8	Zinc finger protein with KRAB and SCAN domains 8	Homo sapiens (Human)	PR
Q53GI3	ZNF394	Zinc finger protein 394	Homo sapiens (Human)	PR
O95125	ZNF202	Zinc finger protein 202	Homo sapiens (Human)	PR
Q05516	ZBTB16	Zinc finger and BTB domain-containing protein 16	Homo sapiens (Human)	PR
Q9H116	GZF1	GDNF-inducible zinc finger protein 1	Homo sapiens (Human)	PR
Q8N0Y2	ZNF444	Zinc finger protein 444	Homo sapiens (Human)	PR
Q6P9G9	ZNF449	Zinc finger protein 449	Homo sapiens (Human)	PR
Q8IW36	ZNF695	Zinc finger protein 695	Homo sapiens (Human)	PR
Q5VTD9	GFI1B	Zinc finger protein Gfi-1b	Homo sapiens (Human)	PR
Q6PG37	ZNF790	Zinc finger protein 790	Homo sapiens (Human)	PR
Q9NQV6	PRDM10	PR domain zinc finger protein 10	Homo sapiens (Human)	PR
Q9Y2D9	ZNF652	Zinc finger protein 652	Homo sapiens (Human)	PR
Q5TC79	ZBTB37	Zinc finger and BTB domain-containing protein 37	Homo sapiens (Human)	PR
Q9Y4E5	ZNF451	E3 SUMO-protein ligase ZNF451	Homo sapiens (Human)	PR
Q8ND82	ZNF280C	Zinc finger protein 280C	Homo sapiens (Human)	PR
Q49AA0	ZFP69	Zinc finger protein 69 homolog	Homo sapiens (Human)	PR
O43298	ZBTB43	Zinc finger and BTB domain-containing protein 43	Homo sapiens (Human)	PR
Q9Y330	ZBTB12	Zinc finger and BTB domain-containing protein 12	Homo sapiens (Human)	PR
Q13105	ZBTB17	Zinc finger and BTB domain-containing protein 17	Homo sapiens (Human)	PR
P51508	ZNF81	Zinc finger protein 81	Homo sapiens (Human)	PR
Q5JNZ3	ZNF311	Zinc finger protein 311	Homo sapiens (Human)	PR
Q9BRR0	ZKSCAN3	Zinc finger protein with KRAB and SCAN domains 3	Homo sapiens (Human)	PR
Q969J2	ZKSCAN4	Zinc finger protein with KRAB and SCAN domains 4	Homo sapiens (Human)	PR
P49910	ZNF165	Zinc finger protein 165	Homo sapiens (Human)	PR
Q9Y4X4	KLF12	Krueppel-like factor 12	Homo sapiens (Human)	PR
P10074	ZBTB48	Telomere zinc finger-associated protein	Homo sapiens (Human)	PR
P17010	ZFX	Zinc finger X-chromosomal protein	Homo sapiens (Human)	PR
Q9H5H4	ZNF768	Zinc finger protein 768	Homo sapiens (Human)	PR
Q6NSZ9	ZSCAN25	Zinc finger and SCAN domain-containing protein 25	Homo sapiens (Human)	PR
Q9Y2L8	ZKSCAN5	Zinc finger protein with KRAB and SCAN domains 5	Homo sapiens (Human)	PR
Q86UZ6	ZBTB46	Zinc finger and BTB domain-containing protein 46	Homo sapiens (Human)	PR
Q9NX65	ZSCAN32	Zinc finger and SCAN domain-containing protein 32	Homo sapiens (Human)	PR
O14771	ZNF213	Zinc finger protein 213	Homo sapiens (Human)	PR
Q8IWY8	ZSCAN29	Zinc finger and SCAN domain-containing protein 29	Homo sapiens (Human)	PR
Q8NCP5	ZBTB44	Zinc finger and BTB domain-containing protein 44	Homo sapiens (Human)	PR
P41182	BCL6	B-cell lymphoma 6 protein	Homo sapiens (Human)	PR
Q9NQX0	PRDM6	Putative histone-lysine N-methyltransferase PRDM6	Homo sapiens (Human)	PR
Q9BU19	ZNF692	Zinc finger protein 692	Homo sapiens (Human)	PR
Q08AG5	ZNF844	Zinc finger protein 844	Homo sapiens (Human)	PR
Q6R2W3	ZBED9	SCAN domain-containing protein 3	Homo sapiens (Human)	PR
P98182	ZNF200	Zinc finger protein 200	Homo sapiens (Human)	PR
Q9UK11	ZNF223	Zinc finger protein 223	Homo sapiens (Human)	PR
O15156	ZBTB7B	Zinc finger and BTB domain-containing protein 7B	Homo sapiens (Human)	PR
Q6ZMS7	ZNF783	Zinc finger protein 783	Homo sapiens (Human)	PR
P59923	ZNF445	Zinc finger protein 445	Homo sapiens (Human)	PR
Q8N859	ZNF713	Zinc finger protein 713	Homo sapiens (Human)	PR
Q99612	KLF6	Krueppel-like factor 6	Homo sapiens (Human)	PR
Q8TD17	ZNF398	Zinc finger protein 398	Homo sapiens (Human)	PR
P52739	ZNF131	Zinc finger protein 131	Homo sapiens (Human)	PR
A6NGD5	ZSCAN5C	Zinc finger and SCAN domain-containing protein 5C	Homo sapiens (Human)	PR
Q05215	EGR4	Early growth response protein 4	Homo sapiens (Human)	PR
Q7Z398	ZNF550	Zinc finger protein 550	Homo sapiens (Human)	PR
Q9Y2K1	ZBTB1	Zinc finger and BTB domain-containing protein 1	Homo sapiens (Human)	PR
Q96N20	ZNF75A	Zinc finger protein 75A	Homo sapiens (Human)	PR
A6NJL1	ZSCAN5B	Zinc finger and SCAN domain-containing protein 5B	Homo sapiens (Human)	PR
A1YPR0	ZBTB7C	Zinc finger and BTB domain-containing protein 7C	Homo sapiens (Human)	PR
Q9NWS9	ZNF446	Zinc finger protein 446	Homo sapiens (Human)	PR
P24278	ZBTB25	Zinc finger and BTB domain-containing protein 25	Homo sapiens (Human)	PR
Q96N38	ZNF714	Zinc finger protein 714	Homo sapiens (Human)	PR
Q86YH2	ZNF280B	Zinc finger protein 280B	Homo sapiens (Human)	PR
O08584	Klf6	Krueppel-like factor 6	Mus musculus (Mouse)	PR
Q61164	Ctcf	Transcriptional repressor CTCF	Mus musculus (Mouse)	PR
Q810A1	Znf18	Zinc finger protein 18	Mus musculus (Mouse)	PR
Q8BGS3	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Mus musculus (Mouse)	PR
Q00899	Yy1	Transcriptional repressor protein YY1	Mus musculus (Mouse)	PR
P41183	Bcl6	B-cell lymphoma 6 protein homolog	Mus musculus (Mouse)	PR
Q9DAI4	Zbtb43	Zinc finger and BTB domain-containing protein 43	Mus musculus (Mouse)	PR
O70237	Gfi1b	Zinc finger protein Gfi-1b	Mus musculus (Mouse)	PR
Q99KZ6	Znf639	Zinc finger protein 639	Mus musculus (Mouse)	PR
Q9Z1D9	Znf394	Zinc finger protein 394	Mus musculus (Mouse)	PR
Q9CXE0	Prdm5	PR domain zinc finger protein 5	Mus musculus (Mouse)	PR
P43300	Egr3	Early growth response protein 3	Mus musculus (Mouse)	PR
Q9DAU9	Znf654	Zinc finger protein 654	Mus musculus (Mouse)	PR
Q9R1Y5	Hic1	Hypermethylated in cancer 1 protein	Mus musculus (Mouse)	PR
Q8R0T2	Znf768	Zinc finger protein 768	Mus musculus (Mouse)	PR
Q9WVG7	Osr1	Protein odd-skipped-related 1	Mus musculus (Mouse)	PR
Q8BI73	Znf775	Zinc finger protein 775	Mus musculus (Mouse)	PR
Q8VCZ7	Zbtb7c	Zinc finger and BTB domain-containing protein 7C	Mus musculus (Mouse)	PR
Q91VN1	Znf24	Zinc finger protein 24	Mus musculus (Mouse)	PR
Q9DB38	Znf580	Zinc finger protein 580	Mus musculus (Mouse)	PR
A7KBS4	Zscan4d	Zinc finger and SCAN domain containing protein 4D	Mus musculus (Mouse)	PR
Q91VW9	Zkscan3	Zinc finger protein with KRAB and SCAN domains 3	Mus musculus (Mouse)	PR
P10925	Zfy1	Zinc finger Y-chromosomal protein 1	Mus musculus (Mouse)	PR
P08046	Egr1	Early growth response protein 1	Mus musculus (Mouse)	PR
Q3TTC2	Yy2	Transcription factor YY2	Mus musculus (Mouse)	PR
Q3UTQ7	Prdm10	PR domain zinc finger protein 10	Mus musculus (Mouse)	PR
Q6P3Y5	Znf280c	Zinc finger protein 280C	Mus musculus (Mouse)	PR
Q9ERU3	Znf22	Zinc finger protein 22	Mus musculus (Mouse)	PR
Q8VIG1	Rest	RE1-silencing transcription factor	Mus musculus (Mouse)	PR
Q9Z1D8	Zkscan5	Zinc finger protein with KRAB and SCAN domains 5	Mus musculus (Mouse)	PR
Q8BID6	Zbtb46	Zinc finger and BTB domain-containing protein 46	Mus musculus (Mouse)	PR
P17012	Zfx	Zinc finger X-chromosomal protein	Mus musculus (Mouse)	PR
Q9WUK6	Zbtb18	Zinc finger and BTB domain-containing protein 18	Mus musculus (Mouse)	PR
O35738	Klf12	Krueppel-like factor 12	Mus musculus (Mouse)	PR
B2RXC5	Znf382	Zinc finger protein 382	Mus musculus (Mouse)	PR
O08900	Ikzf3	Zinc finger protein Aiolos	Mus musculus (Mouse)	PR
Q5DU09	Znf652	Zinc finger protein 652	Mus musculus (Mouse)	PR
Q5RJ54	Zscan26	Zinc finger and SCAN domain-containing protein 26	Mus musculus (Mouse)	PR
Q8BLM0	Klf8	Krueppel-like factor 8	Mus musculus (Mouse)	PR
Q99JB0	Klf7	Krueppel-like factor 7	Mus musculus (Mouse)	PR
Q8R0A2	Zbtb44	Zinc finger and BTB domain-containing protein 44	Mus musculus (Mouse)	PR
P20662	Zfy2	Zinc finger Y-chromosomal protein 2	Mus musculus (Mouse)	PR
Q80VJ6	Zscan4c	Zinc finger and SCAN domain containing protein 4C	Mus musculus (Mouse)	PR
Q3URS2	Zscan4f	Zinc finger and SCAN domain containing protein 4F	Mus musculus (Mouse)	PR
Q60980	Klf3	Krueppel-like factor 3	Mus musculus (Mouse)	PR
Q8K3J5	Znf131	Zinc finger protein 131	Mus musculus (Mouse)	PR
Q9Z2K3	Znf394	Zinc finger protein 394	Rattus norvegicus (Rat)	PR
Q642B9	Znf18	Zinc finger protein 18	Rattus norvegicus (Rat)	PR
B0K011	Osr1	Protein odd-skipped-related 1	Rattus norvegicus (Rat)	PR
D3ZUU2	Gzf1	GDNF-inducible zinc finger protein 1	Rattus norvegicus (Rat)	PR
B1WBU4	Zbtb8a	Zinc finger and BTB domain-containing protein 8A	Rattus norvegicus (Rat)	PR
Q7TNK3	Znf24	Zinc finger protein 24	Rattus norvegicus (Rat)	PR
O35819	Klf6	Krueppel-like factor 6	Rattus norvegicus (Rat)	PR
Q9R1D1	Ctcf	Transcriptional repressor CTCF	Rattus norvegicus (Rat)	PR
P43301	Egr3	Early growth response protein 3	Rattus norvegicus (Rat)	PR
P08154	Egr1	Early growth response protein 1	Rattus norvegicus (Rat)	PR
A0JPL0	Znf382	Zinc finger protein 382	Rattus norvegicus (Rat)	PR
Q4KLI1	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Rattus norvegicus (Rat)	PR
A1L1J6	Znf652	Zinc finger protein 652	Rattus norvegicus (Rat)	PR
Q9SHD0	ZAT4	Zinc finger protein ZAT4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0P4X6	zbtb44	Zinc finger and BTB domain-containing protein 44	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A4II20	egr1	Early growth response protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6P882	zbtb8a.2	Zinc finger and BTB domain-containing protein 8A.2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q567C6	znf367	Zinc finger protein 367	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
A7Y7X5	znf711	Zinc finger protein 711	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MFNSMTPPPI	SSYGEPCCLR	PLPSQGAPSV	GTEGLSGPPF	CHQANLMSGP	HSYGPARETN
70	80	90	100	110	120
SCTEGPLFSS	PRSAVKLTKK	RALSISPLSD	ASLDLQTVIR	TSPSSLVAFI	NSRCTSPGGS
130	140	150	160	170	180
YGHLSIGTMS	PSLGFPAQMN	HQKGPSPSFG	VQPCGPHDSA	RGGMIPHPQS	RGPFPTCQLK
190	200	210	220	230	240
SELDMLVGKC	REEPLEGDMS	SPNSTGIQDP	LLGMLDGRED	LEREEKREPE	SVYETDCRWD
250	260	270	280	290	300
GCSQEFDSQE	QLVHHINSEH	IHGERKEFVC	HWGGCSRELR	PFKAQYMLVV	HMRRHTGEKP
310	320	330	340	350	360
HKCTFEGCRK	SYSRLENLKT	HLRSHTGEKP	YMCEHEGCSK	AFSNASDRAK	HQNRTHSNEK
370	380	390	400	410	420
PYVCKLPGCT	KRYTDPSSLR	KHVKTVHGPD	AHVTKRHRGD	GPLPRAPSIS	TVEPKREREG
430	440	450	460	470	480
GPIREESRLT	VPEGAMKPQP	SPGAQSSCSS	DHSPAGSAAN	TDSGVEMTGN	AGGSTEDLSS
490	500	510	520	530	540
LDEGPCIAGT	GLSTLRRLEN	LRLDQLHQLR	PIGTRGLKLP	SLSHTGTTVS	RRVGPPVSLE
550	560	570	580	590	600
RRSSSSSSIS	SAYTVSRRSS	LASPFPPGSP	PENGASSLPG	LMPAQHYLLR	ARYASARGGG
610	620	630	640	650	660
TSPTAASSLD	RIGGLPMPPW	RSRAEYPGYN	PNAGVTRRAS	DPAQAADRPA	PARVQRFKSL
670	680	690	700	710	720
GCVHTPPTVA	GGGQNFDPYL	PTSVYSPQPP	SITENAAMDA	RGLQEEPEVG	TSMVGSGLNP
730	740	750	760	770	780
YMDFPPTDTL	GYGGPEGAAA	EPYGARGPGS	LPLGPGPPTN	YGPNPCPQQA	SYPDPTQETW
790	800	810	820	830	840
GEFPSHSGLY	PGPKALGGTY	SQCPRLEHYG	QVQVKPEQGC	PVGSDSTGLA	PCLNAHPSEG
850	860	870	880	890	900
PPHPQPLFSH	YPQPSPPQYL	QSGPYTQPPP	DYLPSEPRPC	LDFDSPTHST	GQLKAQLVCN
910	920	930	940	950	960
YVQSQQELLW	EGGGREDAPA	QEPSYQSPKF	LGGSQVSPSR	AKAPVNTYGP	GFGPNLPNHK
970	980	990	1000	1010	1020
SGSYPTPSPC	HENFVVGANR	ASHRAAAPPR	LLPPLPTCYG	PLKVGGTNPS	CGHPEVGRLG
1030	1040	1050	1060	1070	1080
GGPALYPPPE	GQVCNPLDSL	DLDNTQLDFV	AILDEPQGLS	PPPSHDQRGS	SGHTPPPSGP
1090	1100
PNMAVGNMSV	LLRSLPGETE	FLNSSA