Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

5 structures for P08134

Entry ID Method Resolution Chain Position Source
1Z2C X-ray 300 A A/C 1-193 PDB
2GCN X-ray 185 A A 1-181 PDB
2GCO X-ray 140 A A/B 1-181 PDB
2GCP X-ray 215 A A 1-181 PDB
AF-P08134-F1 Predicted AlphaFoldDB

122 variants for P08134

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1204217869
CA341669604
3 A>P No ClinGen
TOPMed
gnomAD
CA341669605
rs1204217869
3 A>T No ClinGen
TOPMed
gnomAD
CA341669601
rs1484661530
3 A>V No ClinGen
gnomAD
rs549460700
CA1010505
4 I>F No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA1010504
rs775884207
4 I>T No ClinGen
ExAC
gnomAD
CA28961529
rs549460700
4 I>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs751438534
CA1010503
5 R>* No ClinGen
ExAC
TOPMed
gnomAD
CA341669593
rs1341176142
5 R>Q No ClinGen
gnomAD
TCGA novel 6 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1804292
CA28961498
7 K>N No ClinGen
gnomAD
rs1570832100
CA341669567
9 V>G No ClinGen
Ensembl
rs777122070
CA1010501
11 V>F No ClinGen
ExAC
gnomAD
rs777122070
CA341669559
11 V>I No ClinGen
ExAC
gnomAD
rs1279883584
CA341669534
15 A>T No ClinGen
gnomAD
CA28961475
rs774806474
16 C>F No ClinGen
Ensembl
CA341669521
rs1368561952
17 G>R No ClinGen
gnomAD
rs1570832032
CA341669505
19 T>P No ClinGen
Ensembl
CA1010498
rs532814642
20 C>F No ClinGen
1000Genomes
ExAC
gnomAD
CA1010497
rs778283490
22 L>F No ClinGen
ExAC
gnomAD
rs754465217
CA1010496
23 I>V No ClinGen
ExAC
gnomAD
rs779724269
CA1010494
31 P>L No ClinGen
ExAC
gnomAD
rs1306776701
CA341669409
33 V>I No ClinGen
gnomAD
TCGA novel 35 V>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA341669393
rs1373957183
35 V>D No ClinGen
gnomAD
rs867290320
CA28961425
36 P>L No ClinGen
Ensembl
rs751468245
CA1010489
38 V>A No ClinGen
ExAC
rs1225428332
CA341669331
44 A>G No ClinGen
TOPMed
gnomAD
CA341669318
rs1445187406
46 I>N No ClinGen
gnomAD
CA341669320
rs1279096579
46 I>V No ClinGen
gnomAD
CA28961398
rs113742657
48 V>A No ClinGen
Ensembl
CA1010487
rs775687775
49 D>E No ClinGen
ExAC
TOPMed
gnomAD
CA1010485
rs142648390
50 G>S No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1051591442
CA28961379
51 K>R No ClinGen
Ensembl
CA341669277
rs1325886799
52 Q>R No ClinGen
gnomAD
rs1570830882
CA341669257
53 V>G No ClinGen
Ensembl
rs1291714036
CA341669243
56 A>S No ClinGen
gnomAD
TCGA novel 63 Q>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 65 D>Y Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs760987953
CA1010458
66 Y>S No ClinGen
ExAC
gnomAD
COSM893969
CA341669155
rs1285399896
68 R>Q Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
NCI-TCGA
gnomAD
rs772515757
CA1010456
70 R>W No ClinGen
ExAC
gnomAD
CA28961044
rs768341873
79 V>I No ClinGen
Ensembl
rs111933338
CA1010452
82 M>V No ClinGen
ExAC
gnomAD
CA341669042
rs1007576553
86 I>L No ClinGen
gnomAD
rs780741469
CA1010451
86 I>N No ClinGen
ExAC
gnomAD
CA28961035
rs1007576553
86 I>V No ClinGen
gnomAD
CA341669021
rs1475122235
89 P>S No ClinGen
gnomAD
TCGA novel 90 D>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA341668996
rs1196046097
92 L>P No ClinGen
gnomAD
CA28960820
rs982075258
95 I>F No ClinGen
TOPMed
CA341668966
rs982075258
95 I>V No ClinGen
TOPMed
rs1012573175
CA28960819
96 P>A No ClinGen
Ensembl
CA1010425
rs779030492
99 W>R No ClinGen
ExAC
gnomAD
rs754946696
CA1010424
100 T>S No ClinGen
ExAC
gnomAD
TCGA novel 107 C>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1240537712
CA341668819
116 G>V No ClinGen
gnomAD
rs750672121
CA1010420
119 K>E No ClinGen
ExAC
gnomAD
rs367869187
CA28960787
120 D>E No ClinGen
ESP
VAR_051974
CA28960788
rs11538959
120 D>H No ClinGen
UniProt
Ensembl
dbSNP
rs969698119
CA341668789
121 L>M No ClinGen
TOPMed
gnomAD
rs969698119
CA28960786
121 L>V No ClinGen
TOPMed
gnomAD
TCGA novel 124 D>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA341668741
rs1242466017
127 T>I No ClinGen
TOPMed
rs1374625555
CA341668695
134 M>T No ClinGen
gnomAD
CA341668660
rs1354608494
137 E>* No ClinGen
TOPMed
CA341668658
rs1448612311
137 E>G No ClinGen
TOPMed
rs1159815720
CA341668653
138 P>A No ClinGen
gnomAD
rs368489891
CA341668648
139 V>I No ClinGen
ESP
ExAC
TOPMed
rs368489891
CA1010399
139 V>L No ClinGen
ESP
ExAC
TOPMed
CA341668643
rs202016325
140 R>G No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs147557411
CA28960317
140 R>P No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA1010396
rs147557411
140 R>Q No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA1010397
rs202016325
140 R>W No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA1010394
rs760269743
143 E>G No ClinGen
ExAC
gnomAD
CA341668618
rs1192411071
144 G>S No ClinGen
TOPMed
gnomAD
rs749927529
CA1010393
144 G>V No ClinGen
ExAC
gnomAD
CA1010392
COSM347133
rs767339526
145 R>W lung [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
CA341668597
rs1355603125
146 D>E No ClinGen
gnomAD
rs761556555
CA1010390
146 D>H No ClinGen
ExAC
rs935568461
CA28960274
147 M>I No ClinGen
gnomAD
rs138756182
CA341668583
148 A>E No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1263606082
CA341668585
148 A>S No ClinGen
gnomAD
CA1010389
rs138756182
148 A>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs376797998
CA1010387
150 R>P No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA1010386
rs376797998
150 R>Q No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1044096844
COSM291487
CA28960228
150 R>W large_intestine [Cosmic] No ClinGen
cosmic curated
gnomAD
rs1299248790
CA341668564
151 I>T No ClinGen
gnomAD
rs1389297724
CA341668559
152 S>G No ClinGen
gnomAD
CA341668546
rs1420071448
153 A>V No ClinGen
TOPMed
CA1010382
rs770929898
157 L>F No ClinGen
ExAC
gnomAD
CA341668516
rs770929898
157 L>V No ClinGen
ExAC
gnomAD
CA341668494
rs758818970
159 C>W No ClinGen
ExAC
TOPMed
gnomAD
rs1450806573
CA341668442
165 E>D No ClinGen
gnomAD
TCGA novel 168 R>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA1010376
rs755424695
168 R>Q No ClinGen
ExAC
gnomAD
rs779520374
COSM1560092
CA1010377
168 R>W Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1570827142
CA341668402
170 V>G No ClinGen
Ensembl
CA341668395
rs1429308276
171 F>S No ClinGen
TOPMed
rs767143479
CA1010374
173 M>I No ClinGen
ExAC
gnomAD
rs1216853115
CA341668379
173 M>V No ClinGen
gnomAD
TCGA novel 174 A>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA341668364
rs1370669974
175 T>A No ClinGen
gnomAD
rs1304057988
CA341668353
176 R>L No ClinGen
gnomAD
CA28960130
rs766734264
176 R>W Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA341668330
rs1400178845
179 L>F No ClinGen
gnomAD
CA1010369
rs775128679
180 Q>H No ClinGen
ExAC
TOPMed
gnomAD
CA1010367
rs759393969
182 R>C No ClinGen
ExAC
gnomAD
rs776490490
CA1010366
182 R>H No ClinGen
ExAC
TOPMed
gnomAD
rs771017578
CA1010364
186 R>C No ClinGen
ExAC
gnomAD
CA1010363
rs11538960
186 R>H No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA1010361
rs766896156
187 R>G No ClinGen
ExAC
TOPMed
gnomAD
rs779142435
CA341668267
187 R>P No ClinGen
ExAC
TOPMed
gnomAD
rs779142435
CA1010359
187 R>Q Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA1010360
rs766896156
187 R>W No ClinGen
ExAC
TOPMed
gnomAD
CA1010358
rs755304944
188 R>G No ClinGen
ExAC
gnomAD
rs1200021693
CA341668261
188 R>K No ClinGen
gnomAD
rs2230329
CA28960090
189 G>S No ClinGen
TOPMed
gnomAD
CA341668236
rs1570826836
191 P>R No ClinGen
Ensembl
CA341668229
rs1570826825
192 I>V No ClinGen
Ensembl
TCGA novel 194 L>= Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA341668211
rs1171938191
194 L>R No ClinGen
gnomAD
rs780659247
CA1010356
194 L>S No ClinGen
ExAC
gnomAD

No associated diseases with P08134

1 regional properties for P08134

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 5 - 159 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor ; Cytoplasmic side
  • Cleavage furrow
  • Translocates to the equatorial region before furrow formation in a ECT2-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

12 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
cleavage furrow The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
stereocilium An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

16 GO annotations of biological process

Name Definition
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
apical junction assembly The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cortical cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of I-kappaB kinase/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of lipase activity Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.
positive regulation of protein-containing complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly.
positive regulation of stress fiber assembly Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of cell shape Any process that modulates the surface configuration of a cell.
skeletal muscle satellite cell migration The orderly movement of a skeletal muscle satellite cell from one site to another. Migration of these cells is a key step in the process of growth and repair of skeletal muscle cells.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.
wound healing, spreading of cells The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface.

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q17QI8 Rhov Rho-related GTP-binding protein RhoV Bos taurus (Bovine) PR
Q2HJ68 RND1 Rho-related GTP-binding protein Rho6 Bos taurus (Bovine) PR
P61585 RHOA Transforming protein RhoA Bos taurus (Bovine) PR
Q3ZBW5 RHOB Rho-related GTP-binding protein RhoB Bos taurus (Bovine) PR
Q1RMJ6 RHOC Rho-related GTP-binding protein RhoC Bos taurus (Bovine) PR
Q9PSX7 RHOC Rho-related GTP-binding protein RhoC Gallus gallus (Chicken) PR
P48148 Rho1 Ras-like GTP-binding protein Rho1 Drosophila melanogaster (Fruit fly) PR
O94955 RHOBTB3 Rho-related BTB domain-containing protein 3 Homo sapiens (Human) EV
O94844 RHOBTB1 Rho-related BTB domain-containing protein 1 Homo sapiens (Human) PR
P61586 RHOA Transforming protein RhoA Homo sapiens (Human) PR
P61587 RND3 Rho-related GTP-binding protein RhoE Homo sapiens (Human) PR
P62745 RHOB Rho-related GTP-binding protein RhoB Homo sapiens (Human) PR
Q92730 RND1 Rho-related GTP-binding protein Rho6 Homo sapiens (Human) PR
Q96L33 RHOV Rho-related GTP-binding protein RhoV Homo sapiens (Human) PR
Q8BLR7 Rnd1 Rho-related GTP-binding protein Rho6 Mus musculus (Mouse) PR
P61588 Rnd3 Rho-related GTP-binding protein RhoE Mus musculus (Mouse) PR
Q9DAK3 Rhobtb1 Rho-related BTB domain-containing protein 1 Mus musculus (Mouse) PR
Q9CTN4 Rhobtb3 Rho-related BTB domain-containing protein 3 Mus musculus (Mouse) SS
Q8VDU1 Rhov Rho-related GTP-binding protein RhoV Mus musculus (Mouse) PR
P62746 Rhob Rho-related GTP-binding protein RhoB Mus musculus (Mouse) PR
Q9QUI0 Rhoa Transforming protein RhoA Mus musculus (Mouse) PR
Q62159 Rhoc Rho-related GTP-binding protein RhoC Mus musculus (Mouse) PR
O77683 RND3 Rho-related GTP-binding protein RhoE Sus scrofa (Pig) PR
Q6SA80 Rnd3 Rho-related GTP-binding protein RhoE Rattus norvegicus (Rat) PR
Q9Z1Y0 Rhov Rho-related GTP-binding protein RhoV Rattus norvegicus (Rat) PR
P61589 Rhoa Transforming protein RhoA Rattus norvegicus (Rat) PR
P62747 Rhob Rho-related GTP-binding protein RhoB Rattus norvegicus (Rat) PR
Q9SSX0 RAC1 Rac-like GTP-binding protein 1 Oryza sativa subsp japonica (Rice) PR
Q6Z808 RAC3 Rac-like GTP-binding protein 3 Oryza sativa subsp japonica (Rice) PR
Q68Y52 RAC2 Rac-like GTP-binding protein 2 Oryza sativa subsp japonica (Rice) PR
Q67VP4 RAC4 Rac-like GTP-binding protein 4 Oryza sativa subsp japonica (Rice) PR
Q22038 rho-1 Ras-like GTP-binding protein rhoA Caenorhabditis elegans PR
Q9SU67 ARAC8 Rac-like GTP-binding protein ARAC8 Arabidopsis thaliana (Mouse-ear cress) PR
O82480 ARAC7 Rac-like GTP-binding protein ARAC7 Arabidopsis thaliana (Mouse-ear cress) PR
Q38903 ARAC2 Rac-like GTP-binding protein ARAC2 Arabidopsis thaliana (Mouse-ear cress) PR
O82481 ARAC10 Rac-like GTP-binding protein ARAC10 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT
70 80 90 100 110 120
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD
130 140 150 160 170 180
LRQDEHTRRE LAKMKQEPVR SEEGRDMANR ISAFGYLECS AKTKEGVREV FEMATRAGLQ
190
VRKNKRRRGC PIL