P07947
SS
Gene name |
YES1 (YES) |
Protein name |
Tyrosine-protein kinase Yes |
Names |
EC 2.7.10.2 , Proto-oncogene c-Yes , p61-Yes |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:7525 |
EC number |
2.7.10.2: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The Src-family kinases include Src, Hck, Fyn, Lyn, Lck, Yes, Fgr, Blk and Frk. They are involved in diverse cellular functions such as immune responses and cell survival and proliferation. The SH2 domain binds to the C-terminal regulatory tail, facilitating the SH3-SH2-kinase linker interaction. SH3 domain engages the SH2-kinase linker, which adopts a polyproline type II (PPII) helical conformation. These interactions result in the inhibition of the kinase activity of HCK.
Autoinhibitory domains (AIDs)
Target domain |
277-530 (Protein kinase domain) |
Relief mechanism |
Partner binding, Ligand binding |
Assay |
|
Target domain |
277-530 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Target domain |
277-530 (Protein kinase domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Target domain |
277-530 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
413-437 (Activation loop from InterPro)
Target domain |
277-530 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Register AC et al. (2014) "SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family", Biochemistry, 53, 6910-23
- Boggon TJ et al. (2004) "Structure and regulation of Src family kinases", Oncogene, 23, 7918-27
- Engen JR et al. (2008) "Structure and dynamic regulation of Src-family kinases", Cellular and molecular life sciences : CMLS, 65, 3058-73
- Alvarado JJ et al. (2010) "Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism", The Journal of biological chemistry, 285, 35455-61
- Schindler T et al. (1999) "Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor", Molecular cell, 3, 639-48
- Williams JC et al. (1997) "The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions", Journal of molecular biology, 274, 757-75
- Meng Y et al. (2014) "Locking the active conformation of c-Src kinase through the phosphorylation of the activation loop", Journal of molecular biology, 426, 423-35
- Laham LE et al. (2000) "The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity", Oncogene, 19, 3961-70
- Furlan G et al. (2014) "Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters", The Journal of biological chemistry, 289, 28514-25
- Kükenshöner T et al. (2017) "Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies", Journal of molecular biology, 429, 1364-1380
- Wang Q et al. (2010) "Multicolor monitoring of dysregulated protein kinases in chronic myelogenous leukemia", ACS chemical biology, 5, 887-95
- Sotirellis N et al. (1995) "Autophosphorylation induces autoactivation and a decrease in the Src homology 2 domain accessibility of the Lyn protein kinase", The Journal of biological chemistry, 270, 29773-80
- Williams NK et al. (2009) "Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state", The Journal of biological chemistry, 284, 284-291
Autoinhibited structure
Activated structure
2 structures for P07947
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2HDA | X-ray | 190 A | A | 91-152 | PDB |
| AF-P07947-F1 | Predicted | AlphaFoldDB |
340 variants for P07947
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1331800424 CA401663983 |
2 | G>A | No |
ClinGen gnomAD |
|
|
CA401663925 rs1598910188 |
6 | S>R | No |
ClinGen Ensembl |
|
|
rs760359350 CA8869150 |
8 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA8869151 rs760359350 |
8 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA401663879 rs1568199587 |
9 | N>K | No |
ClinGen Ensembl |
|
|
CA8869149 rs772827942 |
10 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA401663840 rs1171444863 |
12 | P>L | No |
ClinGen Ensembl |
|
|
CA8869147 rs763236969 |
12 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA295407909 rs199902979 |
13 | A>T | No |
ClinGen 1000Genomes |
|
|
rs1182042658 CA401663783 |
18 | P>L | No |
ClinGen gnomAD |
|
|
CA401663758 rs770153511 |
22 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8869145 rs770153511 |
22 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1200937757 CA401663738 |
25 | V>L | No |
ClinGen gnomAD |
|
|
rs745992838 CA8869144 |
26 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8869143 rs776618133 |
27 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1568199526 CA401663713 |
29 | V>M | No |
ClinGen Ensembl |
|
|
rs771024922 CA8869142 |
31 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA8869141 rs202188142 |
32 | Y>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1316526672 CA401663680 |
33 | G>E | No |
ClinGen gnomAD |
|
|
rs1243053955 CA401663670 |
34 | A>G | No |
ClinGen gnomAD |
|
|
CA295407889 rs143977576 |
35 | E>D | No |
ClinGen Ensembl |
|
|
rs563453845 CA8869139 |
36 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs563453845 CA8869140 |
36 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1381607613 CA401663654 |
36 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
CA8869138 rs747890953 |
37 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs61734346 CA8869137 |
38 | T>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA295407873 rs200714782 |
39 | V>M | No |
ClinGen 1000Genomes |
|
|
CA401663600 rs1329628720 |
42 | C>R | No |
ClinGen TOPMed |
|
|
rs765855267 CA8869134 |
43 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767099976 CA8869131 |
44 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs763332220 CA8869130 COSM438397 |
46 | S>L | breast [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1417752080 CA401663543 |
47 | A>V | No |
ClinGen gnomAD |
|
|
CA401663523 rs1250237194 |
49 | G>V | No |
ClinGen gnomAD |
|
|
rs1476046695 CA401663515 |
50 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
CA295407856 rs942811630 |
51 | A>V | No |
ClinGen Ensembl |
|
|
CA8869127 rs374204484 |
52 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8869124 rs747014698 |
58 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747014698 CA401663417 |
58 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs541013973 CA8869125 |
58 | S>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8869123 rs200594254 |
59 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs748599712 CA295407838 |
60 | T>I | No |
ClinGen Ensembl |
|
|
rs772368524 CA8869122 |
61 | P>Q | No |
ClinGen ExAC gnomAD |
|
|
CA8869121 rs747985513 |
63 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA401663374 rs1447099331 |
63 | G>R | No |
ClinGen gnomAD |
|
|
rs1387077624 CA401663346 |
65 | S>F | No |
ClinGen gnomAD |
|
|
rs754780823 CA8869119 |
66 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA8869117 rs201966473 |
67 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs755634074 CA8869116 |
68 | V>I | No |
ClinGen ExAC |
|
|
rs200860807 CA295407822 |
69 | T>A | No |
ClinGen 1000Genomes |
|
|
CA8869114 COSM990026 rs749885349 |
69 | T>M | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed |
|
CA401663307 rs1366908527 |
70 | P>L | No |
ClinGen TOPMed |
|
|
CA401663294 rs1160569400 |
71 | F>C | No |
ClinGen gnomAD |
|
|
CA295407816 rs139250574 |
71 | F>L | No |
ClinGen Ensembl |
|
|
rs751198391 CA295407800 |
73 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8869111 rs751198391 |
73 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1481596527 CA401663253 |
75 | S>F | No |
ClinGen gnomAD |
|
|
rs1200046320 CA401663260 |
75 | S>P | No |
ClinGen gnomAD |
|
|
rs1350770505 CA401663248 |
76 | S>P | No |
ClinGen TOPMed |
|
|
rs1199294016 CA401663235 |
77 | S>L | No |
ClinGen gnomAD |
|
|
CA8869108 rs200058716 |
80 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8869107 rs372333387 |
81 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs147228514 CA8869106 |
82 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1002693165 CA401663182 |
83 | S>G | No |
ClinGen gnomAD |
|
|
rs773387962 CA8869105 |
83 | S>R | No |
ClinGen ExAC |
|
|
CA295407773 rs1002693165 |
83 | S>R | No |
ClinGen gnomAD |
|
|
rs1404239381 CA401663150 |
85 | Y>C | No |
ClinGen gnomAD |
|
|
CA8869101 rs768402137 |
87 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs576673688 CA8869103 |
87 | A>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs768402137 CA8869102 |
87 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8869100 rs749053147 |
88 | G>S | No |
ClinGen ExAC |
|
|
rs1221978553 CA401662963 |
89 | L>F | No |
ClinGen TOPMed |
|
|
rs779877047 CA8869099 |
90 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs373561285 CA8869075 |
91 | G>D | No |
ClinGen ESP ExAC gnomAD |
|
|
rs769552759 CA8869074 |
93 | V>G | No |
ClinGen ExAC |
|
|
rs1170614927 CA401662588 |
94 | T>A | No |
ClinGen TOPMed |
|
|
rs1568196571 CA401662563 |
95 | I>M | No |
ClinGen Ensembl |
|
|
rs111416313 CA8869073 |
95 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA295405161 rs371390237 |
97 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs371390237 CA8869071 |
97 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1372989572 CA401662504 |
100 | Y>D | No |
ClinGen TOPMed gnomAD |
|
|
CA8869069 rs746473585 |
100 | Y>S | No |
ClinGen ExAC gnomAD |
|
|
CA401662494 rs1391993092 |
101 | D>N | No |
ClinGen gnomAD |
|
|
CA401662484 rs1555685496 |
101 | D>V | No |
ClinGen Ensembl |
|
|
rs529754493 CA8869068 |
104 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed |
|
|
rs368534424 CA295405136 |
107 | T>A | No |
ClinGen ESP TOPMed |
|
|
rs1445866806 CA401662416 |
109 | D>G | No |
ClinGen gnomAD |
|
|
CA8869067 rs747726944 |
110 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs747726944 CA8869066 |
110 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA8869065 rs117449313 |
113 | K>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs756534766 CA8869064 |
116 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1010928891 CA295405124 COSM990024 |
117 | R>I | endometrium [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
rs958248764 CA295405119 |
118 | F>C | No |
ClinGen TOPMed |
|
|
CA401662183 rs374613149 |
124 | T>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs374613149 CA8869062 |
124 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8869040 rs751986438 |
126 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA295403325 rs994489136 |
129 | W>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1301994388 CA401661744 |
132 | R>G | No |
ClinGen gnomAD |
|
|
CA8869039 rs764289588 |
132 | R>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs374650269 CA8869037 |
134 | I>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8869038 rs758401112 |
134 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8869035 rs202083013 COSM990013 |
135 | A>T | large_intestine endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA401661684 rs1178582114 |
136 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1187206077 CA401661628 |
138 | K>N | No |
ClinGen gnomAD |
|
|
rs1187206077 CA401661631 |
138 | K>N | No |
ClinGen gnomAD |
|
|
CA401661634 rs1428436896 |
138 | K>R | No |
ClinGen gnomAD |
|
|
rs1185239817 CA401661598 |
139 | N>K | No |
ClinGen TOPMed |
|
|
CA401661612 rs1486865241 |
139 | N>S | No |
ClinGen gnomAD |
|
|
rs1240623963 CA401661554 |
142 | I>F | No |
ClinGen gnomAD |
|
|
CA401661556 rs1240623963 |
142 | I>V | No |
ClinGen gnomAD |
|
|
CA8869033 rs766059693 |
148 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1221995875 CA401661448 |
149 | P>T | No |
ClinGen gnomAD |
|
|
CA401661409 rs1323471649 |
151 | D>H | No |
ClinGen gnomAD |
|
|
rs773011806 CA8869031 |
153 | I>L | No |
ClinGen ExAC gnomAD |
|
|
CA295403262 rs1049595243 |
154 | Q>R | No |
ClinGen gnomAD |
|
|
rs148854441 CA295403259 |
155 | A>T | No |
ClinGen ESP TOPMed |
|
|
rs1171730009 CA401660837 COSM1389821 |
158 | W>R | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
rs779141765 CA8869017 |
160 | F>C | No |
ClinGen ExAC gnomAD |
|
|
CA401660799 rs1378147464 |
160 | F>V | No |
ClinGen gnomAD |
|
|
rs1472827564 CA401660771 |
162 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
rs754039021 CA8869015 |
164 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs1352628035 CA401660746 |
164 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA8869012 rs750379503 |
173 | L>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8869011 rs767301609 |
174 | N>S | No |
ClinGen ExAC |
|
|
CA8869010 rs372906108 |
177 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA295402430 rs372906108 |
177 | N>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8869009 rs774045264 |
179 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8869008 rs371352602 |
179 | R>Q | No |
ClinGen ExAC TOPMed |
|
|
rs762751679 CA8869006 |
184 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs774998072 CA8869004 |
189 | T>K | No |
ClinGen ExAC gnomAD |
|
|
CA8869003 rs771329396 |
190 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA401660463 rs1339728801 |
191 | K>E | No |
ClinGen gnomAD |
|
|
CA401660405 rs1171411031 |
192 | G>D | No |
ClinGen TOPMed |
|
|
CA401660399 rs1314880628 |
193 | A>T | No |
ClinGen gnomAD |
|
|
CA401660378 rs1373064734 |
194 | Y>F | No |
ClinGen TOPMed |
|
|
VAR_041879 rs34580680 CA8868984 |
198 | I>V | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs1050998183 CA295402312 |
199 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs185293600 CA8868982 |
199 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs185293600 CA8868983 |
199 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA401660310 rs1386230265 |
200 | D>G | No |
ClinGen gnomAD |
|
|
CA8868981 rs773492700 |
201 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA401660272 rs1290821333 |
202 | D>G | No |
ClinGen gnomAD |
|
|
CA401660283 rs1598900796 |
202 | D>N | No |
ClinGen Ensembl |
|
|
CA401660230 rs1380590632 |
205 | R>M | No |
ClinGen TOPMed gnomAD |
|
|
CA401660212 rs1452146077 |
206 | G>V | No |
ClinGen gnomAD |
|
|
rs772407330 CA8868980 |
208 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA295402294 rs933918760 |
214 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA8868978 rs375437397 |
215 | R>G | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1450501503 CA401660089 |
215 | R>T | No |
ClinGen gnomAD |
|
|
CA8868977 rs768729901 |
219 | N>H | No |
ClinGen ExAC gnomAD |
|
|
rs557201481 CA8868976 |
219 | N>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs867692140 CA401660015 |
220 | G>D | No |
ClinGen TOPMed |
|
|
rs867692140 CA295402282 |
220 | G>V | No |
ClinGen TOPMed |
|
|
rs766385590 CA8868974 |
223 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA295402274 rs950954198 |
224 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA401659908 rs1186208968 |
229 | Q>R | No |
ClinGen TOPMed |
|
|
rs1268490756 CA401659899 |
230 | F>L | No |
ClinGen TOPMed |
|
|
rs1325610352 CA401659883 |
231 | D>G | No |
ClinGen gnomAD |
|
|
CA8868973 rs746080500 |
232 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA401659871 rs746080500 |
232 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA295402258 rs1027839627 |
234 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA8868970 rs751544565 |
236 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1187386658 CA401659779 |
240 | Y>H | No |
ClinGen Ensembl |
|
|
CA8868969 rs530952013 |
241 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757945173 CA401659763 |
241 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757945173 CA8868968 |
241 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401659386 rs1411014653 |
244 | A>T | No |
ClinGen gnomAD |
|
|
CA8868957 rs775480874 |
245 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs558434523 CA8868956 |
246 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA401659293 rs1389205596 |
250 | K>T | No |
ClinGen gnomAD |
|
|
CA8868955 rs746141725 |
253 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1446280630 CA401659251 |
253 | T>I | No |
ClinGen gnomAD |
|
|
CA401659247 rs1186498894 COSM438389 |
254 | V>L | breast [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1275516375 CA401659235 |
255 | C>Y | No |
ClinGen TOPMed |
|
|
rs199822485 CA8868953 |
257 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1482202678 CA401659165 |
259 | K>I | No |
ClinGen gnomAD |
|
|
rs887599562 CA295401121 |
262 | T>I | No |
ClinGen Ensembl |
|
|
rs1341514002 CA401659055 |
266 | A>T | No |
ClinGen gnomAD |
|
|
CA401658982 rs1248433273 |
269 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs777880481 CA8868951 |
272 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs375415998 CA295401113 |
273 | P>L | No |
ClinGen ESP |
|
|
CA8868950 rs758304599 |
274 | R>* | No |
ClinGen ExAC gnomAD |
|
|
CA8868949 rs752661671 |
274 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA8868948 rs764716556 |
275 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA401658858 rs1369386784 |
275 | E>V | No |
ClinGen gnomAD |
|
|
CA401658809 rs1598898374 |
278 | R>* | No |
ClinGen Ensembl |
|
|
rs754509357 CA401658805 |
278 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754509357 CA8868947 |
278 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8868945 rs765960384 |
279 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA8868944 rs762187395 |
280 | E>* | No |
ClinGen ExAC |
|
|
rs1234571429 CA401658746 |
281 | V>D | No |
ClinGen gnomAD |
|
|
rs751882704 CA8868943 |
281 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs35126906 VAR_041880 CA8868942 |
282 | K>R | No |
ClinGen UniProt ExAC dbSNP gnomAD |
|
|
CA8868941 rs763427480 |
283 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1269695911 CA401658726 |
284 | G>R | No |
ClinGen gnomAD |
|
|
rs776058735 CA8868940 |
285 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA295401079 rs199903309 |
285 | Q>R | No |
ClinGen 1000Genomes |
|
|
rs1289372970 CA401658639 |
287 | C>* | No |
ClinGen gnomAD |
|
|
CA8868938 rs759600003 |
289 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA8868936 rs188857712 |
290 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1474404631 CA401658569 |
292 | W>C | No |
ClinGen Ensembl |
|
|
rs747200359 CA8868935 |
293 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA295400975 rs1054788462 |
294 | G>V | No |
ClinGen TOPMed |
|
|
rs765723765 CA8868917 |
300 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401658326 rs1227116172 |
303 | A>E | No |
ClinGen gnomAD |
|
|
rs1318314308 CA401658301 |
304 | I>M | No |
ClinGen gnomAD |
|
|
CA8868915 rs201651859 |
304 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771109224 CA8868914 |
309 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1043585918 CA295400966 |
311 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
CA8868913 rs377532925 |
312 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs868024987 CA295400963 |
313 | M>I | No |
ClinGen Ensembl |
|
|
CA295400960 rs913708701 |
316 | A>G | No |
ClinGen TOPMed |
|
|
CA8868910 rs747922199 |
321 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs778738989 CA8868909 |
324 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA401658144 rs1188367598 |
325 | K>R | No |
ClinGen gnomAD |
|
|
CA295400953 rs144591033 |
329 | H>N | No |
ClinGen ESP TOPMed |
|
|
rs1462023222 CA401658091 |
332 | L>P | No |
ClinGen gnomAD |
|
|
rs1265594540 CA401658078 |
334 | P>L | No |
ClinGen gnomAD |
|
|
rs952181168 CA295400943 |
336 | Y>* | No |
ClinGen TOPMed gnomAD |
|
|
COSM1611418 rs986140676 CA401658068 |
336 | Y>C | liver [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs986140676 CA295400946 |
336 | Y>F | No |
ClinGen TOPMed gnomAD |
|
|
CA401658071 rs1310003225 |
336 | Y>H | No |
ClinGen gnomAD |
|
|
CA401658052 rs1294904121 |
339 | V>D | No |
ClinGen gnomAD |
|
|
rs779596788 CA8868906 |
339 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA401658043 rs1434151124 |
341 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA8868904 rs750080195 |
345 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA8868903 rs780838371 |
348 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1171248381 CA401657981 |
350 | F>I | No |
ClinGen gnomAD |
|
|
CA401657967 rs1388595429 |
351 | M>I | No |
ClinGen gnomAD |
|
|
rs1411693530 CA401657971 |
351 | M>V | No |
ClinGen gnomAD |
|
|
rs758709210 CA8868902 |
353 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA8868901 rs753062108 |
354 | G>* | No |
ClinGen ExAC gnomAD |
|
|
rs1348485947 CA401657929 |
355 | S>N | No |
ClinGen gnomAD |
|
|
rs1265223582 CA401657917 |
357 | L>I | No |
ClinGen TOPMed |
|
|
CA401657908 rs1432620928 |
358 | D>Y | No |
ClinGen TOPMed |
|
|
CA401657887 rs1405582366 |
361 | K>E | No |
ClinGen gnomAD |
|
|
CA8868877 rs750476648 |
363 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA8868878 rs756288996 |
363 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA8868876 rs570496446 |
364 | D>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8868874 rs146633417 |
364 | D>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs570496446 CA8868875 |
364 | D>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs753197372 CA295399982 |
365 | G>R | No |
ClinGen Ensembl |
|
|
rs1598895247 CA401657851 |
366 | K>N | No |
ClinGen Ensembl |
|
|
rs1568189215 CA401657855 |
366 | K>T | No |
ClinGen Ensembl |
|
|
rs763879192 CA8868873 |
367 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401657825 rs1219769338 |
370 | L>H | No |
ClinGen gnomAD |
|
|
rs762678626 CA8868872 |
371 | P>S | No |
ClinGen ExAC |
|
|
CA8868871 rs775428573 |
376 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA295399977 rs201882590 |
376 | M>V | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA8868870 rs769675468 |
378 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1480460086 CA401657776 |
378 | A>P | No |
ClinGen gnomAD |
|
|
CA401657773 rs769675468 |
378 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs57905842 CA295399958 |
379 | Q>H | No |
ClinGen ESP |
|
|
rs745757580 CA8868869 |
379 | Q>P | No |
ClinGen ExAC |
|
|
rs760048255 CA8868846 |
380 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA8868845 rs773025552 |
382 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs773025552 CA401657266 |
382 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs944649564 CA295398593 |
383 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA8868844 rs529647749 |
384 | M>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs747772462 CA8868843 |
385 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA8868840 rs746389614 |
386 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA8868839 rs781492606 |
387 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1398312600 CA401657197 |
387 | I>V | No |
ClinGen gnomAD |
|
|
rs1007155838 CA295398570 |
388 | E>K | No |
ClinGen Ensembl |
|
|
rs757380529 CA8868838 |
389 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA295398563 rs140526381 |
390 | M>V | No |
ClinGen ESP TOPMed |
|
|
CA401657082 rs1465077979 |
395 | R>* | No |
ClinGen TOPMed gnomAD |
|
|
CA401657083 rs1465077979 |
395 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
COSM989952 CA295398559 rs910562293 |
395 | R>Q | endometrium [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
CA401657068 rs1170077387 |
396 | D>A | No |
ClinGen gnomAD |
|
|
rs986350587 CA295398555 |
398 | R>W | No |
ClinGen TOPMed |
|
|
rs751552293 CA8868837 |
399 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA401657017 rs1187921871 |
401 | N>D | No |
ClinGen gnomAD |
|
|
CA401656995 rs1444084601 |
402 | I>T | No |
ClinGen gnomAD |
|
|
CA8868834 rs752901062 |
406 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs758664744 CA8868835 |
406 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA295398529 rs768048101 |
409 | V>A | No |
ClinGen Ensembl |
|
|
CA8868832 rs765080545 |
409 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1341641488 CA401656857 |
412 | I>M | No |
ClinGen gnomAD |
|
|
CA401656787 rs1598892608 |
418 | A>T | No |
ClinGen Ensembl |
|
|
rs1307578893 CA401656745 |
421 | I>V | No |
ClinGen TOPMed |
|
|
CA295398519 rs199707539 |
423 | D>E | No |
ClinGen 1000Genomes |
|
|
CA8868829 rs766182225 |
424 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760267714 CA8868828 |
424 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1334054013 CA401656689 |
425 | E>K | No |
ClinGen gnomAD |
|
|
rs1287740866 CA401656654 |
427 | T>S | No |
ClinGen TOPMed |
|
|
rs997710873 CA295398500 |
428 | A>S | No |
ClinGen Ensembl |
|
|
CA401656614 rs371854059 |
430 | Q>P | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA295398484 rs371854059 |
430 | Q>R | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA401670158 rs1289628269 |
431 | G>D | No |
ClinGen gnomAD |
|
|
CA8868806 rs761347968 |
436 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA8868805 rs774168125 |
439 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA295454209 rs151302880 |
440 | A>G | No |
ClinGen ESP TOPMed |
|
|
rs762636176 CA8868803 |
440 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA8868802 rs776905108 |
444 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA295454197 rs201472161 |
445 | L>P | No |
ClinGen 1000Genomes |
|
|
rs1384930568 CA401669980 |
448 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA8868799 rs542568142 |
448 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA401669912 rs1457539887 |
455 | V>I | No |
ClinGen gnomAD |
|
|
CA8868798 rs772156124 |
457 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1156835741 CA401669858 |
459 | G>A | No |
ClinGen gnomAD |
|
|
rs1344624141 CA401669840 |
461 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1456836942 CA401669828 |
462 | Q>P | No |
ClinGen gnomAD |
|
|
CA8868796 rs779230964 |
465 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA295454149 rs575134173 |
466 | V>I | No |
ClinGen 1000Genomes |
|
|
rs779772570 CA8868793 |
470 | R>* | No |
ClinGen ExAC gnomAD |
|
|
CA8868792 rs755971181 |
470 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8868771 rs368099773 |
475 | G>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8868769 rs757308799 |
479 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA8868770 rs757308799 |
479 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs1223790745 CA401669526 |
479 | R>H | No |
ClinGen TOPMed |
|
|
rs1308515038 CA401669521 |
480 | E>* | No |
ClinGen TOPMed |
|
|
rs537141 CA401669509 |
482 | L>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1194771041 CA401669488 |
484 | Q>H | No |
ClinGen gnomAD |
|
|
rs777211673 CA8868767 |
487 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA8868764 rs764823798 |
491 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs750831029 CA8868762 |
492 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8868763 rs750831029 |
492 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs865811136 CA295446551 |
492 | P>S | No |
ClinGen gnomAD |
|
|
rs1314847226 CA401669432 |
493 | C>Y | No |
ClinGen gnomAD |
|
|
CA8868760 rs762365121 |
494 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1354676545 COSM79318 CA401669421 |
495 | Q>* | ovary [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA401669386 rs1598880567 |
500 | S>T | No |
ClinGen Ensembl |
|
|
CA8868756 rs775603690 |
502 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA401669368 rs1297802051 |
503 | E>K | No |
ClinGen gnomAD |
|
|
CA401669363 rs1458791062 |
503 | E>V | No |
ClinGen gnomAD |
|
|
CA401669326 rs1351983416 |
506 | N>S | No |
ClinGen gnomAD |
|
|
rs1165878342 CA401669267 |
511 | K>T | No |
ClinGen TOPMed |
|
|
rs781191210 CA401669247 |
512 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs916338191 CA295446433 |
513 | P>A | No |
ClinGen TOPMed |
|
|
CA8868752 rs770841486 |
514 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1460152274 CA401669232 |
514 | D>G | No |
ClinGen TOPMed |
|
|
rs746922028 CA8868751 |
523 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401669110 rs1444974817 |
524 | S>F | No |
ClinGen TOPMed |
|
|
CA8868750 rs777706059 |
529 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8868749 rs757867014 |
530 | F>Y | No |
ClinGen ExAC gnomAD |
|
|
CA401669013 rs1194868517 |
533 | T>A | No |
ClinGen gnomAD |
|
|
rs752214006 CA8868748 |
535 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA401668979 rs1219050353 |
536 | Q>* | No |
ClinGen gnomAD |
|
|
rs1598880448 CA401668964 |
537 | Y>S | No |
ClinGen Ensembl |
|
|
rs1230365377 CA401668913 |
541 | E>D | No |
ClinGen gnomAD |
No associated diseases with P07947
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.2 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin filament | A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction |
| phosphotyrosine residue binding | Binding to a phosphorylated tyrosine residue within a protein. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cellular response to platelet-derived growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. |
| cellular response to retinoic acid | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. |
| cellular response to transforming growth factor beta stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| Fc-gamma receptor signaling pathway involved in phagocytosis | An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| leukocyte migration | The movement of a leukocyte within or between different tissues and organs of the body. |
| negative regulation of inflammatory response to antigenic stimulus | Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of peptidyl-tyrosine phosphorylation | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| protein modification process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
| regulation of glucose transmembrane transport | Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of vascular permeability | Any process that modulates the extent to which blood vessels can be pervaded by fluid. |
| T cell costimulation | The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
90 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0JNB0 | FYN | Tyrosine-protein kinase Fyn | Bos taurus (Bovine) | SS |
| Q0VBZ0 | CSK | Tyrosine-protein kinase CSK | Bos taurus (Bovine) | SS |
| Q3ZC95 | BTK | Tyrosine-protein kinase | Bos taurus (Bovine) | EV SS |
| P42683 | LCK | Proto-oncogene tyrosine-protein kinase LCK | Gallus gallus (Chicken) | SS |
| P41239 | CSK | Tyrosine-protein kinase CSK | Gallus gallus (Chicken) | SS |
| P00523 | SRC | Proto-oncogene tyrosine-protein kinase Src | Gallus gallus (Chicken) | EV |
| Q02977 | YRK | Proto-oncogene tyrosine-protein kinase Yrk | Gallus gallus (Chicken) | SS |
| Q8JH64 | BTK | Tyrosine-protein kinase BTK | Gallus gallus (Chicken) | SS |
| Q05876 | FYN | Tyrosine-protein kinase Fyn | Gallus gallus (Chicken) | SS |
| Q75R65 | JAK2 | Tyrosine-protein kinase JAK2 | Gallus gallus (Chicken) | SS |
| P09324 | YES1 | Tyrosine-protein kinase Yes | Gallus gallus (Chicken) | SS |
| Q24592 | hop | Tyrosine-protein kinase hopscotch | Drosophila melanogaster (Fruit fly) | PR |
| P08630 | Btk | Tyrosine-protein kinase Btk | Drosophila melanogaster (Fruit fly) | SS |
| P00528 | Src64B | Tyrosine-protein kinase Src64B | Drosophila melanogaster (Fruit fly) | SS |
| Q9V9J3 | Src42A | Tyrosine-protein kinase Src42A | Drosophila melanogaster (Fruit fly) | SS |
| P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Homo sapiens (Human) | SS |
| O60674 | JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens (Human) | EV |
| P52333 | JAK3 | Tyrosine-protein kinase JAK3 | Homo sapiens (Human) | SS |
| P29597 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | Homo sapiens (Human) | EV |
| P09769 | FGR | Tyrosine-protein kinase Fgr | Homo sapiens (Human) | SS |
| P41240 | CSK | Tyrosine-protein kinase CSK | Homo sapiens (Human) | SS |
| P42680 | TEC | Tyrosine-protein kinase Tec | Homo sapiens (Human) | SS |
| P51451 | BLK | Tyrosine-protein kinase Blk | Homo sapiens (Human) | SS |
| P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Homo sapiens (Human) | SS |
| Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Homo sapiens (Human) | EV |
| P43405 | SYK | Tyrosine-protein kinase SYK | Homo sapiens (Human) | EV |
| P43403 | ZAP70 | Tyrosine-protein kinase ZAP-70 | Homo sapiens (Human) | EV |
| Q13882 | PTK6 | Protein-tyrosine kinase 6 | Homo sapiens (Human) | EV |
| P07948 | LYN | Tyrosine-protein kinase Lyn | Homo sapiens (Human) | SS |
| P06241 | FYN | Tyrosine-protein kinase Fyn | Homo sapiens (Human) | SS |
| P12931 | SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (Human) | EV |
| P06239 | LCK | Tyrosine-protein kinase Lck | Homo sapiens (Human) | EV |
| P08631 | HCK | Tyrosine-protein kinase HCK | Homo sapiens (Human) | EV |
| P42685 | FRK | Tyrosine-protein kinase FRK | Homo sapiens (Human) | EV |
| Q06187 | BTK | Tyrosine-protein kinase BTK | Homo sapiens (Human) | EV |
| P42679 | MATK | Megakaryocyte-associated tyrosine-protein kinase | Homo sapiens (Human) | SS |
| Q14289 | PTK2B | Protein-tyrosine kinase 2-beta | Homo sapiens (Human) | PR |
| Q05397 | PTK2 | Focal adhesion kinase 1 | Homo sapiens (Human) | EV |
| Q13470 | TNK1 | Non-receptor tyrosine-protein kinase TNK1 | Homo sapiens (Human) | PR |
| Q07912 | TNK2 | Activated CDC42 kinase 1 | Homo sapiens (Human) | EV |
| P16591 | FER | Tyrosine-protein kinase Fer | Homo sapiens (Human) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P42684 | ABL2 | Tyrosine-protein kinase ABL2 | Homo sapiens (Human) | SS |
| P00519 | ABL1 | Tyrosine-protein kinase ABL1 | Homo sapiens (Human) | EV |
| Q9R117 | Tyk2 | Non-receptor tyrosine-protein kinase TYK2 | Mus musculus (Mouse) | SS |
| P08103 | Hck | Tyrosine-protein kinase HCK | Mus musculus (Mouse) | SS |
| P16277 | Blk | Tyrosine-protein kinase Blk | Mus musculus (Mouse) | SS |
| Q62270 | Srms | Tyrosine-protein kinase Srms | Mus musculus (Mouse) | SS |
| Q64434 | Ptk6 | Protein-tyrosine kinase 6 | Mus musculus (Mouse) | SS |
| P05480 | Src | Proto-oncogene tyrosine-protein kinase Src | Mus musculus (Mouse) | EV |
| P14234 | Fgr | Tyrosine-protein kinase Fgr | Mus musculus (Mouse) | SS |
| P35991 | Btk | Tyrosine-protein kinase BTK | Mus musculus (Mouse) | EV |
| P41241 | Csk | Tyrosine-protein kinase CSK | Mus musculus (Mouse) | EV |
| P25911 | Lyn | Tyrosine-protein kinase Lyn | Mus musculus (Mouse) | EV |
| Q62137 | Jak3 | Tyrosine-protein kinase JAK3 | Mus musculus (Mouse) | SS |
| Q62120 | Jak2 | Tyrosine-protein kinase JAK2 | Mus musculus (Mouse) | EV |
| P06240 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Mus musculus (Mouse) | SS |
| P24604 | Tec | Tyrosine-protein kinase Tec | Mus musculus (Mouse) | SS |
| P39688 | Fyn | Tyrosine-protein kinase Fyn | Mus musculus (Mouse) | SS |
| P52332 | Jak1 | Tyrosine-protein kinase JAK1 | Mus musculus (Mouse) | SS |
| Q03526 | Itk | Tyrosine-protein kinase ITK/TSK | Mus musculus (Mouse) | SS |
| P41242 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q922K9 | Frk | Tyrosine-protein kinase FRK | Mus musculus (Mouse) | SS |
| Q04736 | Yes1 | Tyrosine-protein kinase Yes | Mus musculus (Mouse) | SS |
| A1Y2K1 | FYN | Tyrosine-protein kinase Fyn | Sus scrofa (Pig) | SS |
| O19064 | JAK2 | Tyrosine-protein kinase JAK2 | Sus scrofa (Pig) | SS |
| Q62662 | Frk | Tyrosine-protein kinase FRK | Rattus norvegicus (Rat) | SS |
| Q62844 | Fyn | Tyrosine-protein kinase Fyn | Rattus norvegicus (Rat) | SS |
| Q07014 | Lyn | Tyrosine-protein kinase Lyn | Rattus norvegicus (Rat) | SS |
| P50545 | Hck | Tyrosine-protein kinase HCK | Rattus norvegicus (Rat) | SS |
| Q9WUD9 | Src | Proto-oncogene tyrosine-protein kinase Src | Rattus norvegicus (Rat) | SS |
| Q01621 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Rattus norvegicus (Rat) | SS |
| Q6P6U0 | Fgr | Tyrosine-protein kinase Fgr | Rattus norvegicus (Rat) | SS |
| Q62689 | Jak2 | Tyrosine-protein kinase JAK2 | Rattus norvegicus (Rat) | SS |
| Q63272 | Jak3 | Tyrosine-protein kinase JAK3 | Rattus norvegicus (Rat) | SS |
| P32577 | Csk | Tyrosine-protein kinase CSK | Rattus norvegicus (Rat) | SS |
| P41243 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Rattus norvegicus (Rat) | SS |
| F1LM93 | Yes1 | Tyrosine-protein kinase Yes | Rattus norvegicus (Rat) | SS |
| G5ECJ6 | csk-1 | Tyrosine-protein kinase csk-1 | Caenorhabditis elegans | SS |
| O45539 | src-2 | Tyrosine protein-kinase src-2 | Caenorhabditis elegans | SS |
| G5EE56 | src-1 | Tyrosine protein-kinase src-1 | Caenorhabditis elegans | SS |
| Q2MHE4 | HT1 | Serine/threonine/tyrosine-protein kinase HT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22558 | STY8 | Serine/threonine-protein kinase STY8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWL6 | STY17 | Serine/threonine-protein kinase STY17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4JTP5 | STY46 | Serine/threonine-protein kinase STY46 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F1RDG9 | fynb | Tyrosine-protein kinase fynb | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O12990 | jak1 | Tyrosine-protein kinase JAK1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q1JPZ3 | src | Proto-oncogene tyrosine-protein kinase Src | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6EWH2 | fyna | Tyrosine-protein kinase fyna | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A1A5H8 | yes1 | Tyrosine-protein kinase yes | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGCIKSKENK | SPAIKYRPEN | TPEPVSTSVS | HYGAEPTTVS | PCPSSSAKGT | AVNFSSLSMT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PFGGSSGVTP | FGGASSSFSV | VPSSYPAGLT | GGVTIFVALY | DYEARTTEDL | SFKKGERFQI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| INNTEGDWWE | ARSIATGKNG | YIPSNYVAPA | DSIQAEEWYF | GKMGRKDAER | LLLNPGNQRG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IFLVRESETT | KGAYSLSIRD | WDEIRGDNVK | HYKIRKLDNG | GYYITTRAQF | DTLQKLVKHY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TEHADGLCHK | LTTVCPTVKP | QTQGLAKDAW | EIPRESLRLE | VKLGQGCFGE | VWMGTWNGTT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KVAIKTLKPG | TMMPEAFLQE | AQIMKKLRHD | KLVPLYAVVS | EEPIYIVTEF | MSKGSLLDFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KEGDGKYLKL | PQLVDMAAQI | ADGMAYIERM | NYIHRDLRAA | NILVGENLVC | KIADFGLARL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IEDNEYTARQ | GAKFPIKWTA | PEAALYGRFT | IKSDVWSFGI | LQTELVTKGR | VPYPGMVNRE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VLEQVERGYR | MPCPQGCPES | LHELMNLCWK | KDPDERPTFE | YIQSFLEDYF | TATEPQYQPG |
| ENL |