P07802

SS
Gene name
PRKAR1A
Protein name
cAMP-dependent protein kinase type I-alpha regulatory subunit
Names
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397091
EC number
Protein Class

Descriptions

PKA is a major intracellular receptor of cAMP and modulates diverse cellular signalings. The N-terminal regulatory domain contains a pseudosubstrate sequence that may interact with the catalytic kinase domain.

Autoinhibitory domains (AIDs)

96-100 (Autoinhibitory segment) SS

Target domain

136-252 (Cyclic nucleotide-binding domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P07802

Entry ID Method Resolution Chain Position Source
AF-P07802-F1 Predicted AlphaFoldDB

No variants for P07802

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P07802

No associated diseases with P07802

7 regional properties for P07802

Type Name Position InterPro Accession
domain Cyclic nucleotide-binding domain 136 - 252 IPR000595-1
domain Cyclic nucleotide-binding domain 254 - 375 IPR000595-2
domain cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain 24 - 61 IPR003117
conserved_site Cyclic nucleotide-binding, conserved site 163 - 179 IPR018488-1
conserved_site Cyclic nucleotide-binding, conserved site 199 - 216 IPR018488-2
conserved_site Cyclic nucleotide-binding, conserved site 281 - 297 IPR018488-3
conserved_site Cyclic nucleotide-binding, conserved site 323 - 340 IPR018488-4

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
cAMP binding Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
cAMP-dependent protein kinase regulator activity Modulation of the activity of the enzyme cAMP-dependent protein kinase.

2 GO annotations of biological process

Name Definition
regulation of meiotic cell cycle process involved in oocyte maturation Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
regulation of protein phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

22 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P00515 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit Bos taurus (Bovine) EV
P31322 PRKAR2B cAMP-dependent protein kinase type II-beta regulatory subunit Bos taurus (Bovine) EV
P00514 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit Bos taurus (Bovine) EV
Q5ZM91 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit Gallus gallus (Chicken) SS
P81900 Pka-R2 cAMP-dependent protein kinase type II regulatory subunit Drosophila melanogaster (Fruit fly) PR
P16905 Pka-R1 cAMP-dependent protein kinase type I regulatory subunit Drosophila melanogaster (Fruit fly) PR
P13861 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit Homo sapiens (Human) PR
P31323 PRKAR2B cAMP-dependent protein kinase type II-beta regulatory subunit Homo sapiens (Human) PR
Q96M20 CNBD2 Cyclic nucleotide-binding domain-containing protein 2 Homo sapiens (Human) PR
P31321 PRKAR1B cAMP-dependent protein kinase type I-beta regulatory subunit Homo sapiens (Human) EV
P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit Homo sapiens (Human) EV
P12849 Prkar1b cAMP-dependent protein kinase type I-beta regulatory subunit Mus musculus (Mouse) PR
P12367 Prkar2a cAMP-dependent protein kinase type II-alpha regulatory subunit Mus musculus (Mouse) PR
P31324 Prkar2b cAMP-dependent protein kinase type II-beta regulatory subunit Mus musculus (Mouse) PR
Q9D5U8 Cnbd2 Cyclic nucleotide-binding domain-containing protein 2 Mus musculus (Mouse) PR
Q9DBC7 Prkar1a cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed] Mus musculus (Mouse) SS
P05207 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit Sus scrofa (Pig) SS
P12369 Prkar2b cAMP-dependent protein kinase type II-beta regulatory subunit Rattus norvegicus (Rat) PR
P12368 Prkar2a cAMP-dependent protein kinase type II-alpha regulatory subunit Rattus norvegicus (Rat) PR
P81377 Prkar1b cAMP-dependent protein kinase type I-beta regulatory subunit Rattus norvegicus (Rat) PR
P09456 Prkar1a cAMP-dependent protein kinase type I-alpha regulatory subunit Rattus norvegicus (Rat) SS
P30625 kin-2 cAMP-dependent protein kinase regulatory subunit Caenorhabditis elegans SS
10 20 30 40 50 60
MASGSTASEE ERSLRECELY VQKHNIQALL KDSIVQLCTA RPERPMAFLR EYFERLEKEE
70 80 90 100 110 120
AKQIQNLQKA SARADSREDE ISPPPPNPVV KGRRRRGAIS AEVYTEEDAA SYVRKVIPKD
130 140 150 160 170 180
YKTMAALAKA IEKNVLFSHL DDNERSDIFD AMFPVSFIAG ETVIQQGDEG DNFYVIDQGE
190 200 210 220 230 240
MDVYVNNEWA TSVGEGGSFG ELALIYGTPR AATVKAKTNV KLWGNDRDSY RRILMGSTLR
250 260 270 280 290 300
KRKMYEEFLS KVSILESLDK WERLTVADAL EPVQFEDGQK IVVQGEPGDE FFIILEGSAA
310 320 330 340 350 360
VLQRRSENEE FVEVGRLGPS DYFGEIALLM NRPRAATVVA RGPLKCVKLD RPRFERVLGP
370
CSDILKRNIQ QYNSFVSLSV