AiPD: Autoinhibited Protein Database

P07199

Gene name	CENPB
Protein name	Major centromere autoantigen B
Names	Centromere protein B, CENP-B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1059
EC number
Protein Class

Descriptions

CENP-B Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. This protein possesses intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues, known as D/E repeats. These D/E repeats can cause autoinhibition through intramolecular electrostatic interaction with HMG boxes and modulate binding to DNA. This autoinhibited state can transition into the uninhibited complex with DNA through an electrostatically driven induced-fit process, which accelerates the target DNA search kinetics in the presence of non-functional high-affinity ligands ('decoys').

Autoinhibitory domains (AIDs)

406-435 (D/E repeat) SS

Target domain	1-136 (DNA-binding domain)
Relief mechanism
Assay

AID

406-435 (D/E repeat)

Target domain

1-136 (DNA-binding domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P07199

Entry ID	Method	Resolution	Chain	Position	Source
1BW6	NMR	-	A	1-56	PDB
1HLV	X-ray	250 A	A	1-129	PDB
1UFI	X-ray	165 A	A/B/C/D	540-599	PDB
6KDR	X-ray	211 A	D/E	2-10	PDB
AF-P07199-F1	Predicted				AlphaFoldDB

438 variants for P07199

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs768406404	3	P>R		No	ExAC gnomAD
rs267605931	3	P>S		No	Ensembl
rs1237739956	11	R>Q		No	gnomAD
rs1265462304	11	R>W		No	gnomAD
rs1345240536	21	E>D		No	gnomAD
rs1407244321	22	E>D		No	gnomAD
rs780512777	22	E>K		No	ExAC gnomAD
rs905224989	25	D>N		No	TOPMed gnomAD
rs1347102548	27	R>L		No	gnomAD
TCGA novel	28	K>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs763387256	34	R>H		No	ExAC gnomAD
rs1434795060	36	N>S		No	gnomAD
COSM4964654	46	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs770909940	47	K>N		No	ExAC gnomAD
TCGA novel	50	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1386081685	50	R>S		No	TOPMed gnomAD
rs774130454	51	A>S		No	ExAC gnomAD
rs1381090845	52	I>L		No	gnomAD
rs1321353770	54	A>V		No	gnomAD
COSM3799529	56	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs145734304	58	K>N		No	ESP ExAC gnomAD
TCGA novel	59	Y>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1568495766	60	G>R		No	Ensembl
rs769595472	61	V>M		No	ExAC gnomAD
rs745496146	62	A>P		No	ExAC gnomAD
rs745496146	62	A>S		No	ExAC gnomAD
rs756692439	63	S>P		No	ExAC gnomAD
rs533106029	64	T>I		No	1000Genomes ExAC gnomAD
rs202224991	64	T>P		No	ExAC gnomAD
TCGA novel	69	N>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs753269687	70	K>R		No	ExAC gnomAD
rs1169850506	76	K>R		No	TOPMed
COSM723696	77	L>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1380781333	78	E>K		No	TOPMed gnomAD
rs1380781333	78	E>Q		No	TOPMed gnomAD
rs1338929899	79	G>S		No	gnomAD
COSM1471464	81	L>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1167131221	83	A>T		No	gnomAD
rs1168609954	88	I>M		No	gnomAD
rs1391956615	88	I>T		No	gnomAD
rs1443469427	89	R>L		No	gnomAD
rs867843060	94	P>A		No	gnomAD
rs1250192663	94	P>R		No	gnomAD
rs867843060	94	P>S		No	gnomAD
rs1367525260	96	K>R		No	TOPMed
rs1194468678	97	G>S		No	gnomAD
TCGA novel	99	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM723697	102	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	109	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs745717178	113	M>L		No	ExAC gnomAD
TCGA novel	118	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1372244679	121	G>D		No	gnomAD
rs1362864096	133	V>A		No	gnomAD
rs1362864096	133	V>G		No	gnomAD
rs748658170	136	S>G		No	ExAC gnomAD
rs755273196	137	G>S		No	ExAC gnomAD
rs531687996	139	A>P		No	1000Genomes
rs766681316	139	A>V		No	ExAC TOPMed gnomAD
rs561079262	140	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs561079262	140	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs1333215305	141	A>G		No	TOPMed
rs1369467816	141	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1333215305	141	A>V		No	TOPMed
rs761949795	142	R>C		No	ExAC gnomAD
rs975691838	146	A>T		No	TOPMed
rs1352066935	147	A>S		No	gnomAD
rs1352066935	147	A>T		No	gnomAD
rs542584402	147	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs776448311	148	P>R		No	ExAC gnomAD
rs1363667913	148	P>S		No	TOPMed gnomAD
TCGA novel	149	R>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs773064269	149	R>C		No	ExAC TOPMed gnomAD
rs771677387	149	R>H		No	ExAC TOPMed gnomAD
TCGA novel	149	R>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs773064269	149	R>S		No	ExAC TOPMed gnomAD
rs747708976	150	T>P		No	ExAC gnomAD
rs1413132890	151	P>S		No	gnomAD
rs1479704969	153	A>E		No	gnomAD
rs1248979638	155	A>S		No	gnomAD
rs1248979638	155	A>T		No	gnomAD
rs769161961	157	P>A		No	ExAC gnomAD
rs572112095	157	P>Q		No	1000Genomes ExAC TOPMed gnomAD
rs756496687	159	A>E		No	ExAC gnomAD
rs780404896	159	A>T		No	ExAC gnomAD
rs1236440118	161	P>L		No	TOPMed
rs1257221408	162	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1268479257	163	E>K		No	gnomAD
rs894008394	166	G>D		No	TOPMed gnomAD
rs781437027	167	G>E		No	ExAC gnomAD
rs750641264	167	G>W		No	ExAC gnomAD
rs201262188	168	S>G		No	ExAC gnomAD
rs560373821	170	T>I		No	1000Genomes
rs751590543	171	G>D		No	ExAC gnomAD
rs751590543	171	G>V		No	ExAC gnomAD
rs1329456527	172	W>C		No	TOPMed gnomAD
rs1458443786	172	W>L		No	gnomAD
rs1388925961	173	R>L		No	gnomAD
rs759452919	174	A>P		No	ExAC TOPMed gnomAD
rs759452919	174	A>S		No	ExAC TOPMed gnomAD
rs753776622	175	R>Q		No	ExAC gnomAD
rs200133266	177	E>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1192254824	177	E>Q		No	gnomAD
rs1240384473	179	P>R		No	gnomAD
rs878883694	180	P>L		No	TOPMed
rs1465463217	181	S>P		No	gnomAD
rs771798121	187	A>P		No	ExAC gnomAD
COSM4098338	187	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1280523528	188	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs867023076	189	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1294681306	191	V>M		No	TOPMed gnomAD
rs140102208	193	S>G		No	ESP ExAC TOPMed gnomAD
rs773929504	193	S>N		No	ExAC TOPMed gnomAD
rs768060890	194	A>T		No	ExAC gnomAD
rs749791585	194	A>V		No	ExAC gnomAD
rs780496154	198	S>R		No	ExAC gnomAD
TCGA novel	199	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	201	Y>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1409852994	202	D>G		No	gnomAD
rs1309939310	203	F>L		No	TOPMed
rs369656252	203	F>Y		No	ESP ExAC TOPMed gnomAD
rs1600367957	205	P>S		No	Ensembl
TCGA novel rs1600367947	206	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs556461613	208	A>V		No	1000Genomes ExAC gnomAD
rs1484388993	209	A>G		No	TOPMed gnomAD
rs1181946654	209	A>S		No	TOPMed gnomAD
rs1181946654	209	A>T		No	TOPMed gnomAD
rs1484388993	209	A>V		No	TOPMed gnomAD
rs777853235	213	G>V		No	ExAC TOPMed gnomAD
COSM1307379	216	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs897815576	218	P>L		No	TOPMed gnomAD
rs897815576	218	P>R		No	TOPMed gnomAD
rs1380923882	219	R>C		No	TOPMed gnomAD
rs758472789	219	R>H		No	ExAC TOPMed gnomAD
rs758472789	219	R>P		No	ExAC TOPMed gnomAD
rs1380923882	219	R>S		No	TOPMed gnomAD
rs1441954716	220	Q>P		No	gnomAD
rs753775625	221	A>D		No	ExAC gnomAD
rs1369159816	221	A>P		No	TOPMed gnomAD
rs1384665166	223	Q>K		No	TOPMed gnomAD
rs766276108	224	R>L		No	ExAC gnomAD
COSM4098337	225	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs760710349	226	S>C		No	ExAC gnomAD
rs750199272	226	S>R		No	ExAC gnomAD
rs1178809396	231	A>T		No	gnomAD
COSM723698	234	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs773929979	235	G>S		No	ExAC gnomAD
rs763658114	238	K>R		No	ExAC gnomAD
rs1323093092	240	P>A		No	gnomAD
rs1323093092	240	P>T		No	gnomAD
rs1348985910	241	P>L		No	gnomAD
rs1291791291	245	G>S		No	gnomAD
rs1568495268	246	K>R		No	Ensembl
rs770151730	247	S>L		No	ExAC TOPMed gnomAD
rs112241514	247	S>P		No	Ensembl
rs771299910	251	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs879399143	251	R>H		No	gnomAD
rs1472837172	252	A>E		No	TOPMed gnomAD
rs1184111498	252	A>S		No	gnomAD
rs747225829	253	G>R		No	ExAC gnomAD
rs747225829	253	G>S		No	ExAC gnomAD
rs758481653	255	A>V		No	ExAC TOPMed gnomAD
rs1026671116	256	G>A		No	Ensembl
TCGA novel	257	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs748126240	257	L>R		No	ExAC gnomAD
rs1214608347	258	P>L		No	gnomAD
COSM4098336	261	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs867769633	263	A>T		No	gnomAD
rs1299814146	265	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1299814146	265	S>Y		No	gnomAD
rs996878878	267	G>S		No	Ensembl
rs1368366384	270	T>I		No	gnomAD
rs1288385037	271	T>I		No	TOPMed gnomAD
rs1433115280	273	A>V		No	gnomAD
rs909068515	275	A>G		No	TOPMed
rs372238704	276	K>N		No	ESP ExAC TOPMed gnomAD
rs763706617	276	K>R		No	ExAC gnomAD
rs774824085	279	K>R		No	ExAC gnomAD
rs774824085	279	K>T		No	ExAC gnomAD
rs1267382714	280	A>V		No	gnomAD
rs759981081	284	R>*		No	ExAC gnomAD
rs759981081	284	R>G		No	ExAC gnomAD
rs1209039813	286	A>V		No	gnomAD
rs1323237462	287	A>S		No	gnomAD
rs1448788680	287	A>V		No	TOPMed
rs1254676165	288	E>Q		No	gnomAD
rs781319502	290	R>C		No	gnomAD
COSM1681513 rs1372115231	291	R>W	ovary [Cosmic]	No	cosmic curated TOPMed
rs865816773	296	A>V		No	Ensembl
rs1367517935	297	G>S		No	gnomAD
rs555520508	298	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs868826693	298	R>H		No	gnomAD
rs868826693	298	R>L		No	gnomAD
rs1300889115	301	A>P		No	TOPMed gnomAD
rs147156312	303	S>C		No	ESP ExAC gnomAD
rs147156312	303	S>Y		No	ESP ExAC gnomAD
rs1453532151	307	S>L		No	TOPMed
rs1447125625	308	G>D		No	gnomAD
rs1341362295	310	R>Q		No	gnomAD
rs1188777924	310	R>W		No	gnomAD
rs755165312	311	H>R		No	ExAC gnomAD
rs1483829349	312	V>L		No	gnomAD
rs781321752	315	A>V		No	ExAC gnomAD
rs368864621	316	F>L		No	ESP TOPMed gnomAD
rs751268082	316	F>S		No	ExAC TOPMed gnomAD
rs757098310	316	F>V		No	ExAC TOPMed gnomAD
rs763984128	318	P>L		No	ExAC TOPMed gnomAD
rs1245462924	318	P>S		No	gnomAD
rs1310234570	319	P>S		No	gnomAD
rs1402722094	320	G>A		No	TOPMed gnomAD
rs1397577674	320	G>S		No	TOPMed gnomAD
rs566480942	321	T>I		No	1000Genomes ExAC gnomAD
rs1472220152	322	V>A		No	gnomAD
rs1168709421	322	V>L		No	gnomAD
rs1366364466	324	P>R		No	gnomAD
rs551434705	327	R>K		No	1000Genomes ExAC TOPMed gnomAD
rs551434705	327	R>M		No	1000Genomes ExAC TOPMed gnomAD
rs776871979	332	Q>K		No	ExAC TOPMed gnomAD
rs761275404	334	K>N		No	ExAC TOPMed gnomAD
rs1286164384	335	G>S		No	gnomAD
rs1245848725	338	R>C		No	gnomAD
rs1340821507	338	R>H		No	gnomAD
rs1407875814	340	A>T		No	gnomAD
rs967110721	343	L>P		No	TOPMed
rs1042265178	345	A>T		No	TOPMed gnomAD
rs1458143967	346	M>V		No	gnomAD
rs1180514338	348	A>P		No	gnomAD
rs1198851115	350	E>D		No	gnomAD
rs749431418	354	P>S		No	ExAC gnomAD
rs1292178121	356	G>S		No	gnomAD
rs770738210	357	L>P		No	ExAC TOPMed gnomAD
rs142777704	358	Q>H		No	1000Genomes TOPMed
rs746970763	360	G>D		No	ExAC gnomAD
rs1226356877	361	L>F		No	gnomAD
rs1390088273	362	T>A		No	gnomAD
rs1235451933	366	H>Q		No	TOPMed
rs1328829291	366	H>Y		No	gnomAD
rs148399929	367	F>S		No	ESP ExAC TOPMed gnomAD
rs1387461280	368	V>M		No	gnomAD
rs200811692	370	A>G		No	ExAC gnomAD
rs1157325288	370	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
COSM4098334	372	W>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1172481001	373	Q>R		No	gnomAD
rs1248486393	374	A>S		No	gnomAD
COSM3389743 rs753304095	376	E>K	pancreas [Cosmic]	No	cosmic curated ExAC gnomAD
COSM288372	377	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs761024900	377	P>S		No	ExAC TOPMed gnomAD
rs750992860	378	S>A		No	ExAC gnomAD
COSM6159748	378	S>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs375897463	381	A>T		No	ESP TOPMed gnomAD
rs1218529101	381	A>V		No	gnomAD
rs774695747	382	A>T		No	ExAC TOPMed gnomAD
rs144459328	382	A>V		No	ESP ExAC TOPMed gnomAD
rs763301814	383	C>R		No	ExAC gnomAD
rs775648926	385	R>C		No	ExAC gnomAD
rs1333958799	385	R>H		No	gnomAD
rs746909694	386	E>D		No	ExAC gnomAD
rs769931259	386	E>K		No	ExAC gnomAD
TCGA novel	387	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs777835195	387	A>V		No	ExAC gnomAD
rs1190725730	390	G>E		No	gnomAD
rs1388440344	390	G>R		No	gnomAD
rs1465534390	391	G>D		No	gnomAD
rs1258609909	393	P>S		No	gnomAD
rs754558450	395	A>D		No	ExAC TOPMed gnomAD
rs754558450	395	A>V		No	ExAC TOPMed gnomAD
rs1340808854	396	T>I		No	gnomAD
rs1211595908	396	T>P		No	gnomAD
rs1340808854	396	T>S		No	gnomAD
rs760761824	397	I>M		No	ExAC TOPMed gnomAD
rs1362231882	399	T>A		No	gnomAD
rs1261380621	403	S>G		No	TOPMed
rs1446255115	403	S>N		No	gnomAD
rs1600366842	403	S>R		No	Ensembl
rs779523200	405	G>E		No	ExAC
rs1313984335	407	E>K		No	gnomAD
rs1199745801	408	E>K		No	TOPMed
rs1429722527	409	E>V		No	gnomAD
rs1276441146	410	E>K		No	TOPMed
rs750862703	412	E>K		No	ExAC gnomAD
rs757730302	413	E>D		No	ExAC TOPMed
rs768121518	413	E>K		No	ExAC TOPMed gnomAD
rs1413367961	414	E>K		No	gnomAD
rs529107942	415	E>K		No	1000Genomes ExAC gnomAD
rs754367212	415	E>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs529107942	415	E>Q		No	1000Genomes ExAC gnomAD
rs1239031263	416	E>D		No	gnomAD
rs1465129765	417	E>K		No	TOPMed
rs191679255	419	E>V		No	1000Genomes ExAC TOPMed gnomAD
rs759704025	420	G>D		No	ExAC TOPMed gnomAD
rs765228310	420	G>S		No	ExAC gnomAD
rs1226292690	423	E>Q		No	gnomAD
rs748080776	425	E>D		No	ExAC
rs772004115	425	E>K		No	ExAC gnomAD
rs774073734	426	E>K		No	ExAC
rs1273567897	427	E>D		No	TOPMed
rs1432276673	428	E>D		No	TOPMed
rs1600366625	428	E>G		No	Ensembl
rs768492671	429	G>E		No	ExAC TOPMed
rs768492671	429	G>V		No	ExAC TOPMed
rs1463870627	430	E>G		No	TOPMed
rs779792835	431	E>A		No	ExAC TOPMed
rs779792835	431	E>G		No	ExAC TOPMed
rs748930909	431	E>K		No	ExAC gnomAD
rs1390246446	432	E>G		No	TOPMed
rs1328003800	433	E>A		No	TOPMed
rs1328003800	433	E>G		No	TOPMed
rs1162911059	433	E>K		No	gnomAD
rs1371827419	434	E>G		No	TOPMed
rs1407344480	434	E>K		No	gnomAD
rs1600366513	435	E>G		No	Ensembl
rs13042058	436	G>A		No	ExAC TOPMed gnomAD
rs13042058	436	G>E		No	ExAC TOPMed gnomAD
rs780602403	436	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed
rs13042058	436	G>V		No	ExAC TOPMed gnomAD
rs560113368	437	G>E		No	1000Genomes
rs748211874	438	E>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1600366446	438	E>G		No	Ensembl
rs144899160	438	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs748211874 COSM5140684	438	E>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs1249512778	439	G>E		No	gnomAD
rs1184338498	441	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1245669689	442	L>*		No	TOPMed gnomAD
rs1480653341	442	L>V		No	TOPMed gnomAD
rs1245669689	442	L>W		No	TOPMed gnomAD
rs1323180072	443	G>R		No	gnomAD
rs1395251585	444	E>G		No	TOPMed
rs1274129101	444	E>K		No	gnomAD
rs752938535	447	E>D		No	ExAC TOPMed gnomAD
rs533227646	447	E>K		No	Ensembl
rs1327602524	448	V>E		No	TOPMed gnomAD
rs1327602524	448	V>G		No	TOPMed gnomAD
rs199992333	449	E>*		No	1000Genomes
rs759706920	450	E>D		No	ExAC gnomAD
rs138025965	451	E>D		No	1000Genomes ExAC TOPMed gnomAD
rs1472284168	451	E>Q		No	gnomAD
rs1206471984	452	G>V		No	gnomAD
rs761720824	453	D>N		No	ExAC gnomAD
rs774335332	455	D>N		No	ExAC gnomAD
rs768406399	457	D>G		No	ExAC
rs551419159	459	E>Q		No	ExAC gnomAD
rs769450213	461	E>K		No	ExAC gnomAD
rs1266004626	462	E>A		No	gnomAD
rs745514430	462	E>K		No	ExAC
rs756885952	463	D>G		No	ExAC gnomAD
rs780699266	463	D>N		No	ExAC gnomAD
rs747515195	464	E>K		No	ExAC gnomAD
COSM3799528	465	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs373678745 COSM1200731	468	S>L	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs373678745	468	S>W		No	ESP ExAC TOPMed gnomAD
TCGA novel	469	E>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1041906979	472	E>V		No	Ensembl
rs1299209466	473	A>G		No	gnomAD
rs1299209466	473	A>V		No	gnomAD
rs1157017690	477	A>S		No	TOPMed
rs945775228	477	A>V		No	TOPMed
rs947501798	479	G>R		No	Ensembl
rs912922404	480	V>A		No	TOPMed
rs1433226896	480	V>L		No	TOPMed gnomAD
rs1386115334	481	V>M		No	gnomAD
rs893394617	484	G>D		No	Ensembl
rs760780474	484	G>S		No	ExAC TOPMed gnomAD
rs140633295	487	F>S		No	ESP ExAC TOPMed gnomAD
rs199738908	488	G>R		No	1000Genomes TOPMed gnomAD
rs762912299	489	A>S		No	ExAC gnomAD
rs1187517907	489	A>V		No	gnomAD
rs928661373	490	Y>S		No	TOPMed gnomAD
rs769493561	491	G>S		No	ExAC gnomAD
rs759217770	492	A>S		No	ExAC gnomAD
rs1255957529	493	Q>H		No	TOPMed
rs940799141	494	E>Q		No	Ensembl
rs746568860	496	A>V		No	ExAC gnomAD
rs748676791	497	Q>R		No	ExAC gnomAD
rs1485000639	498	C>W		No	TOPMed
rs748614679	500	T>S		No	ExAC TOPMed gnomAD
rs772638786	500	T>S		No	ExAC gnomAD
rs149144936	503	F>S		No	ESP ExAC TOPMed gnomAD
rs1180295262	508	E>K		No	TOPMed
rs1456930774	514	S>G		No	TOPMed gnomAD
rs1600365941	515	E>D		No	Ensembl
COSM443807	515	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1436558526	518	D>G		No	gnomAD
rs1600365916	519	D>E		No	Ensembl
rs1167453032	519	D>H		No	TOPMed gnomAD
rs1167453032	519	D>N		No	TOPMed gnomAD
rs1600365904	520	E>D		No	Ensembl
rs566794290	522	E>K		No	ExAC gnomAD
rs866979432	523	D>G		No	Ensembl
rs1423568101	523	D>N		No	gnomAD
rs752634687	526	D>G		No	ExAC gnomAD
rs1223826972	528	D>N		No	TOPMed
COSM258766 rs765081320	529	D>N	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1341635347	530	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs141704389	532	D>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs770661500	532	D>N		No	ExAC gnomAD
COSM3363242 rs1600365773	533	E>D	kidney [Cosmic]	No	cosmic curated Ensembl
rs771761547	536	G>S		No	ExAC gnomAD
rs779328212	539	V>L		No	ExAC gnomAD
rs749565823	541	V>I		No	ExAC gnomAD
rs746104845	548	M>I		No	ExAC gnomAD
rs1395407026	549	A>S		No	TOPMed
rs1054138522	550	Y>C		No	TOPMed
rs1428909856	552	A>V		No	TOPMed
rs1223829356	553	M>V		No	gnomAD
rs1011315880	555	K>R		No	Ensembl
TCGA novel	560	S>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs935629273	560	S>Y		No	TOPMed
rs374655035	561	F>L		No	ESP ExAC TOPMed gnomAD
rs200421015	562	P>R		No	ExAC TOPMed gnomAD
rs1251401829	562	P>S		No	gnomAD
TCGA novel	563	I>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1600365629	564	D>A		No	Ensembl
rs1341846872	565	D>E		No	TOPMed
rs893331913	565	D>G		No	Ensembl
rs754967941	566	R>C		No	ExAC gnomAD
rs754967941	566	R>G		No	ExAC gnomAD
rs753648407	566	R>H		No	ExAC TOPMed gnomAD
rs760386998	570	H>N		No	ExAC gnomAD
rs773062211	572	L>F		No	ExAC gnomAD
rs1407973640	573	H>R		No	gnomAD
TCGA novel	574	L>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs557225624	576	H>Q		No	1000Genomes ExAC TOPMed gnomAD
rs775776155	579	V>I		No	ExAC TOPMed gnomAD
rs770202423	580	H>Y		No	ExAC gnomAD
rs1469896763	581	V>G		No	TOPMed
rs1411743980	581	V>L		No	gnomAD
rs746086964	582	T>A		No	ExAC gnomAD
rs368775626	583	R>G		No	ESP TOPMed
rs757341919	587	A>T		No	ExAC gnomAD
rs1165926755	590	A>S		No	TOPMed
COSM3713308 rs747014298	590	A>V	upper_aerodigestive_tract [Cosmic]	No	cosmic curated ExAC gnomAD
rs754812338	593	R>*		No	ExAC gnomAD
rs753881816	593	R>Q		No	ExAC TOPMed gnomAD
TCGA novel	594	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3546275	595	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs766268613	596	G>A		No	ExAC gnomAD
rs1279570028	598	Q>*		No	gnomAD
rs750078348	599	S>N		No	ExAC
rs767027838	600	S>S		No	ExAC gnomAD

No associated diseases with P07199

No regional properties for P07199

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P07199

Functions

		Description
EC Number
Subcellular Localization	Nucleus Chromosome, centromere
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
chromosome, centromeric region	The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
condensed chromosome, centromeric region	The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
pericentric heterochromatin	Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3).

5 GO annotations of molecular function

Name	Definition
centromeric DNA binding	Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis.
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
satellite DNA binding	Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA.
sequence-specific DNA binding	Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6B0B8	TIGD3	Tigger transposable element-derived protein 3	Homo sapiens (Human)	PR

10	20	30	40	50	60
MGPKRRQLTF	REKSRIIQEV	EENPDLRKGE	IARRFNIPPS	TLSTILKNKR	AILASERKYG
70	80	90	100	110	120
VASTCRKTNK	LSPYDKLEGL	LIAWFQQIRA	AGLPVKGIIL	KEKALRIAEE	LGMDDFTASN
130	140	150	160	170	180
GWLDRFRRRH	GVVSCSGVAR	ARARNAAPRT	PAAPASPAAV	PSEGSGGSTT	GWRAREEQPP
190	200	210	220	230	240
SVAEGYASQD	VFSATETSLW	YDFLPDQAAG	LCGGDGRPRQ	ATQRLSVLLC	ANADGSEKLP
250	260	270	280	290	300
PLVAGKSAKP	RAGQAGLPCD	YTANSKGGVT	TQALAKYLKA	LDTRMAAESR	RVLLLAGRLA
310	320	330	340	350	360
AQSLDTSGLR	HVQLAFFPPG	TVHPLERGVV	QQVKGHYRQA	MLLKAMAALE	GQDPSGLQLG
370	380	390	400	410	420
LTEALHFVAA	AWQAVEPSDI	AACFREAGFG	GGPNATITTS	LKSEGEEEEE	EEEEEEEEEG
430	440	450	460	470	480
EGEEEEEEGE	EEEEEGGEGE	ELGEEEEVEE	EGDVDSDEEE	EEDEESSSEG	LEAEDWAQGV
490	500	510	520	530	540
VEAGGSFGAY	GAQEEAQCPT	LHFLEGGEDS	DSDSEEEDDE	EEDDEDEDDD	DDEEDGDEVP
550	560	570	580	590
VPSFGEAMAY	FAMVKRYLTS	FPIDDRVQSH	ILHLEHDLVH	VTRKNHARQA	GVRGLGHQS