P06239
EV
Gene name |
LCK |
Protein name |
Tyrosine-protein kinase Lck |
Names |
Leukocyte C-terminal Src kinase, LSK, Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16, Proto-oncogene Lck, T cell-specific protein-tyrosine kinase, p56-LCK |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:3932 |
EC number |
2.7.10.2: Protein-tyrosine kinases |
Protein Class |
TYROSINE-PROTEIN KINASE (PTHR24418) |
Descriptions
Tyrosine-protein kinase Lck plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. It is included in Src family nonreceptor tyrosine kinases. Src kinase family shares a conserved domain structure consisting of consecutive SH3, SH2, tyrosine kinase, and C-terminal tail. Like other kinases in the same family.
Autoinhibitory domains (AIDs)
Target domain |
245-498 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
Structural analysis |
Target domain |
245-498 (Protein kinase domain) |
Relief mechanism |
|
Assay |
Structural analysis |
Target domain |
245-498 (Protein kinase domain) |
Relief mechanism |
|
Assay |
Structural analysis |
Target domain |
245-498 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
Structural analysis |
Accessory elements
381-405 (Activation loop from InterPro)
Target domain |
245-498 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Boggon TJ et al. (2004) "Structure and regulation of Src family kinases", Oncogene, 23, 7918-27
- Laham LE et al. (2000) "The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity", Oncogene, 19, 3961-70
- Furlan G et al. (2014) "Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters", The Journal of biological chemistry, 289, 28514-25
- Kükenshöner T et al. (2017) "Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies", Journal of molecular biology, 429, 1364-1380
Autoinhibited structure
Activated structure
58 structures for P06239
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1BHF | X-ray | 180 A | A | 119-226 | PDB |
| 1BHH | X-ray | 190 A | PDB | ||
| 1CWD | X-ray | 225 A | L | 127-222 | PDB |
| 1CWE | X-ray | 230 A | A/C | 127-222 | PDB |
| 1FBZ | X-ray | 240 A | A/B | 123-226 | PDB |
| 1H92 | NMR | - | A | 59-120 | PDB |
| 1IJR | X-ray | 220 A | A | 124-226 | PDB |
| 1KIK | NMR | - | A | 64-120 | PDB |
| 1LCJ | X-ray | 180 A | A | 119-226 | PDB |
| 1LCK | X-ray | 250 A | PDB | ||
| 1LKK | X-ray | 100 A | A | 122-226 | PDB |
| 1LKL | X-ray | 180 A | A | 123-226 | PDB |
| 1Q68 | NMR | - | B | 7-35 | PDB |
| 1Q69 | NMR | - | B | 7-35 | PDB |
| 1QPC | X-ray | 160 A | A | 231-509 | PDB |
| 1QPD | X-ray | 200 A | A | 231-509 | PDB |
| 1QPE | X-ray | 200 A | A | 231-509 | PDB |
| 1QPJ | X-ray | 220 A | A | 231-509 | PDB |
| 1X27 | X-ray | 270 A | A/B/C/D/E/F | 64-226 | PDB |
| 2IIM | X-ray | 100 A | A | 59-119 | PDB |
| 2OF2 | X-ray | 200 A | A | 231-501 | PDB |
| 2OF4 | X-ray | 270 A | A | 231-501 | PDB |
| 2OFU | X-ray | 200 A | A | 229-501 | PDB |
| 2OFV | X-ray | 200 A | A/B | 232-498 | PDB |
| 2OG8 | X-ray | 230 A | A/B | 237-499 | PDB |
| 2PL0 | X-ray | 280 A | A | 225-509 | PDB |
| 2ZM1 | X-ray | 210 A | A | 225-509 | PDB |
| 2ZM4 | X-ray | 270 A | A | 225-509 | PDB |
| 2ZYB | X-ray | 255 A | A | 225-509 | PDB |
| 3AC1 | X-ray | 199 A | A | 225-509 | PDB |
| 3AC2 | X-ray | 210 A | A | 225-509 | PDB |
| 3AC3 | X-ray | 255 A | A | 225-509 | PDB |
| 3AC4 | X-ray | 270 A | A | 225-509 | PDB |
| 3AC5 | X-ray | 250 A | A | 225-509 | PDB |
| 3AC8 | X-ray | 230 A | A | 225-509 | PDB |
| 3ACJ | X-ray | 220 A | A | 225-509 | PDB |
| 3ACK | X-ray | 260 A | A | 225-509 | PDB |
| 3AD4 | X-ray | 220 A | A | 225-509 | PDB |
| 3AD5 | X-ray | 200 A | A | 225-509 | PDB |
| 3AD6 | X-ray | 215 A | A | 225-509 | PDB |
| 3B2W | X-ray | 230 A | A | 226-502 | PDB |
| 3BRH | X-ray | 220 A | C/D | 391-397 | PDB |
| 3BYM | X-ray | 200 A | A | 230-501 | PDB |
| 3BYO | X-ray | 200 A | A | 231-501 | PDB |
| 3BYS | X-ray | 220 A | A | 225-501 | PDB |
| 3BYU | X-ray | 230 A | A | 225-501 | PDB |
| 3KMM | X-ray | 280 A | A | 229-509 | PDB |
| 3KXZ | X-ray | 237 A | A | 225-509 | PDB |
| 3LCK | X-ray | 170 A | A | 231-501 | PDB |
| 3MPM | X-ray | 195 A | A | 237-501 | PDB |
| 4C3F | X-ray | 172 A | A | 237-501 | PDB |
| 4D8K | X-ray | 236 A | A | 53-226 | PDB |
| 5MTM | X-ray | 240 A | A | 118-231 | PDB |
| 5MTN | X-ray | 285 A | A | 118-231 | PDB |
| 6H6A | X-ray | 200 A | E/H/K | 2-11 | PDB |
| 6PDJ | X-ray | 181 A | A | 225-509 | PDB |
| 8X2P | X-ray | 140 A | A/B | 119-226 | PDB |
| AF-P06239-F1 | Predicted | AlphaFoldDB |
265 variants for P06239
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA740992 rs145088108 RCV000547015 |
45 | R>Q | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs147431889 RCV000652175 CA740998 |
54 | S>C | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA339636599 rs1393997550 RCV001213943 |
72 | Y>H | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
RCV001048206 rs1640215337 |
90 | I>M | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV001342141 rs1640237880 |
139 | R>missing | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinVar dbSNP |
|
CA741134 rs539280346 RCV000530648 |
187 | D>N | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD |
|
rs11567841 CA741140 RCV000690357 VAR_051697 |
201 | G>S | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs766580359 CA741177 RCV000689981 |
211 | N>I | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs1480132008 RCV001042264 |
218 | T>I | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinVar dbSNP |
|
rs1557585827 RCV000703969 CA339639591 |
268 | T>M | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
RCV000692299 CA741220 rs142611772 |
284 | A>G | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs587777335 VAR_071291 RCV000114989 CA151376 |
341 | L>P | IMD22 Severe combined immunodeficiency due to LCK deficiency [UniProt, ClinVar] | Yes |
ClinGen ClinVar UniProt Ensembl dbSNP |
|
rs1569967422 RCV000991355 |
377 | S>missing | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV001051256 rs1640406042 |
401 | K>* | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV001317326 rs1801124 CA741329 |
431 | T>M | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
RCV001335599 rs1569984631 |
505 | Y>C | Severe combined immunodeficiency due to LCK deficiency [ClinVar] | Yes |
ClinVar dbSNP |
|
rs1257794961 CA339633877 |
5 | C>R | No |
ClinGen gnomAD |
|
|
CA339633907 rs1486428010 |
5 | C>W | No |
ClinGen gnomAD |
|
|
CA740963 rs763977216 |
8 | H>N | No |
ClinGen ExAC gnomAD |
|
|
rs763977216 CA740962 |
8 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs111771386 CA740964 |
9 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA20230157 rs111771386 |
9 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA740965 rs780185907 |
14 | M>L | No |
ClinGen ExAC gnomAD |
|
|
CA740966 rs751726470 |
17 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA339634168 rs1422197069 |
17 | I>V | No |
ClinGen gnomAD |
|
|
rs755284744 CA740967 |
18 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA740968 rs77219908 |
22 | N>T | No |
ClinGen ExAC gnomAD |
|
|
CA339634341 rs1360740802 |
25 | Y>H | No |
ClinGen gnomAD |
|
|
CA740969 rs748563929 |
27 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1126766 CA20230216 |
29 | P>R | No |
ClinGen Ensembl |
|
|
rs749818114 CA339634420 |
30 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749818114 CA740972 |
30 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339634434 rs1342708327 |
31 | D>G | No |
ClinGen gnomAD |
|
|
rs1218166453 CA339634445 |
32 | G>V | No |
ClinGen gnomAD |
|
|
rs770282584 CA740973 |
34 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA740986 rs755220816 |
36 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs564082487 CA740987 |
38 | I>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs752991931 CA740988 |
40 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs756491346 CA740989 |
41 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA339636052 rs1254158000 |
43 | E>G | No |
ClinGen gnomAD |
|
|
rs778290248 CA740990 |
44 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs139649211 CA740991 |
45 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs778252394 CA740993 |
47 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs999073024 CA20230631 |
47 | P>L | No |
ClinGen TOPMed |
|
|
CA740995 rs771590192 |
48 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339636114 rs1404547164 |
51 | Y>C | No |
ClinGen gnomAD |
|
|
rs1404547164 CA339636112 |
51 | Y>F | No |
ClinGen gnomAD |
|
|
CA740996 rs373458731 |
52 | E>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA339636124 rs1443973811 |
53 | G>S | No |
ClinGen gnomAD |
|
|
rs540222297 CA740997 |
54 | S>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA339636139 rs1282058272 |
55 | N>K | No |
ClinGen gnomAD |
|
|
CA740999 rs776547244 |
55 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs761633690 CA741000 |
56 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs568140101 CA741003 |
58 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs151169932 CA20230675 |
59 | S>T | No |
ClinGen ESP |
|
|
CA741005 rs752903747 |
60 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA339636171 rs1476466097 |
61 | L>R | No |
ClinGen TOPMed |
|
|
CA741007 rs764357331 |
62 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs780848515 CA741036 |
63 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs777499240 CA741038 |
68 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA339636592 rs1435317417 |
71 | S>G | No |
ClinGen TOPMed |
|
|
CA741040 rs771045740 |
71 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA741041 rs775683851 |
72 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA339636633 rs1352651866 |
77 | D>N | No |
ClinGen TOPMed |
|
|
rs762005602 CA741045 |
78 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1227459328 CA339636652 |
79 | D>E | No |
ClinGen gnomAD |
|
|
CA741047 rs533969475 |
82 | F>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA339636687 rs1444115742 |
84 | K>N | No |
ClinGen TOPMed |
|
|
CA339636684 rs1301869806 |
84 | K>R | No |
ClinGen gnomAD |
|
|
CA339636691 rs1235039920 |
85 | G>A | No |
ClinGen gnomAD |
|
|
rs1038465388 CA20231012 |
85 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1351729844 CA339636693 |
86 | E>K | No |
ClinGen gnomAD |
|
|
CA339636720 rs1369876947 |
89 | R>H | No |
ClinGen TOPMed |
|
|
rs555714485 CA20231022 |
92 | E>G | No |
ClinGen 1000Genomes |
|
|
CA339636744 rs1231588809 |
93 | Q>R | No |
ClinGen TOPMed |
|
|
CA741068 rs142674647 |
94 | S>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA339636771 rs1448844533 |
95 | G>A | No |
ClinGen TOPMed |
|
|
CA20231198 rs377653414 |
95 | G>S | No |
ClinGen Ensembl |
|
|
CA20231203 rs911037520 |
97 | W>R | No |
ClinGen Ensembl |
|
|
CA20231209 rs201899413 |
98 | W>C | No |
ClinGen 1000Genomes TOPMed |
|
|
rs1569952918 CA339636821 |
102 | S>A | No |
ClinGen Ensembl |
|
|
rs1421255548 CA339636823 |
102 | S>C | No |
ClinGen TOPMed gnomAD |
|
|
CA20231232 rs1022754875 |
103 | L>M | No |
ClinGen TOPMed |
|
|
rs112957416 CA20231237 |
104 | T>I | No |
ClinGen TOPMed |
|
|
CA339636862 rs1462475947 |
106 | G>V | No |
ClinGen gnomAD |
|
|
CA20231267 COSM1687340 rs867588722 |
112 | P>S | skin [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs1429066934 CA339636922 |
115 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA741074 rs757043274 |
119 | A>E | No |
ClinGen ExAC gnomAD |
|
|
rs1441550050 CA339636950 |
119 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA339636968 rs758314746 |
121 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs544255095 CA741078 |
122 | L>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1235129240 CA339636985 |
124 | P>H | No |
ClinGen gnomAD |
|
|
rs773364948 CA741081 |
126 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA741080 rs769883592 |
126 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA339637103 rs1569953941 |
131 | N>T | No |
ClinGen Ensembl |
|
|
CA339637120 rs1368225574 |
132 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
CA339637118 rs1368225574 |
132 | L>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1368225574 CA339637122 |
132 | L>R | No |
ClinGen TOPMed gnomAD |
|
|
CA20231399 rs866632097 |
133 | S>I | No |
ClinGen Ensembl |
|
|
rs1232851236 CA339637143 |
134 | R>H | No |
ClinGen gnomAD |
|
|
rs1202578552 CA339637181 |
137 | A>T | No |
ClinGen gnomAD |
|
|
CA20231420 rs11576031 |
138 | E>D | No |
ClinGen 1000Genomes gnomAD |
|
|
rs772512580 CA741106 |
139 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA339637211 rs1194587513 |
139 | R>W | No |
ClinGen gnomAD |
|
|
CA339637246 rs1193039805 |
142 | L>P | No |
ClinGen gnomAD |
|
|
CA20231450 rs868401007 |
143 | A>E | No |
ClinGen gnomAD |
|
|
CA339637250 rs1455784984 |
143 | A>T | No |
ClinGen gnomAD |
|
|
rs769580260 CA20231453 |
144 | P>S | No |
ClinGen gnomAD |
|
|
rs1569954237 CA339637260 |
145 | G>E | No |
ClinGen Ensembl |
|
|
CA20231464 rs866092612 |
145 | G>W | No |
ClinGen Ensembl |
|
|
CA741108 rs761327722 |
147 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA20231470 rs1015545475 |
148 | H>L | No |
ClinGen TOPMed gnomAD |
|
|
CA741110 rs763681220 |
148 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1166552454 CA339637282 |
149 | G>R | No |
ClinGen TOPMed |
|
|
rs761524121 CA741111 |
155 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA339637388 rs1447922580 |
158 | S>G | No |
ClinGen TOPMed |
|
|
rs868644258 CA20231498 |
158 | S>N | No |
ClinGen gnomAD |
|
|
CA20231500 rs911057675 |
160 | A>V | No |
ClinGen Ensembl |
|
|
CA741123 rs772316081 |
161 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs11576032 CA20231705 |
168 | R>W | No |
ClinGen Ensembl |
|
|
rs1392812560 CA339637650 |
171 | D>N | No |
ClinGen gnomAD |
|
|
CA741127 rs777308034 |
173 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs1008745002 CA20231723 |
174 | Q>K | No |
ClinGen Ensembl |
|
|
rs761356569 CA741128 |
176 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1297382849 CA339637780 |
177 | V>A | No |
ClinGen TOPMed |
|
|
CA741130 rs772673094 |
177 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1569955822 CA339637796 |
178 | V>G | No |
ClinGen Ensembl |
|
|
rs1323990193 CA339637875 |
182 | K>N | No |
ClinGen gnomAD |
|
|
CA339637900 rs1557585028 |
184 | R>C | No |
ClinGen Ensembl |
|
|
CA20231739 rs777578035 |
184 | R>H | No |
ClinGen gnomAD |
|
|
CA741131 rs762734407 |
185 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767406314 CA741135 |
187 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752657839 CA741136 |
188 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA741137 rs757273543 |
188 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1231351915 CA339637995 |
189 | G>D | No |
ClinGen TOPMed |
|
|
CA20231756 rs377122627 |
189 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs377122627 CA741138 |
189 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1277133571 CA339638011 |
190 | G>D | No |
ClinGen TOPMed |
|
|
CA339638136 rs1192340454 |
197 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1211345541 CA339638202 |
200 | P>L | No |
ClinGen TOPMed |
|
|
CA339638215 rs1171376431 |
201 | G>D | No |
ClinGen gnomAD |
|
|
rs769163098 CA741143 |
207 | R>L | No |
ClinGen ExAC gnomAD |
|
|
rs1453879735 CA339638345 |
210 | T>A | No |
ClinGen TOPMed |
|
|
rs751818854 CA741178 |
214 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
CA741180 rs767961556 |
217 | C>R | No |
ClinGen ExAC gnomAD |
|
|
CA339638618 rs1480132008 |
218 | T>K | No |
ClinGen gnomAD |
|
|
COSM1213167 rs527608634 CA741182 |
219 | R>Q | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs559884474 CA339638630 |
219 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA741183 rs778300098 |
222 | R>C | No |
ClinGen ExAC gnomAD |
|
|
COSM185668 rs749760246 CA741184 |
222 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs749760246 CA339638675 |
222 | R>L | No |
ClinGen ExAC gnomAD |
|
|
rs778300098 CA339638673 |
222 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA339638679 rs1406057348 |
223 | P>H | No |
ClinGen TOPMed gnomAD |
|
|
CA339638680 rs1406057348 |
223 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1440485621 CA339638890 |
234 | W>* | No |
ClinGen TOPMed |
|
|
rs143147870 CA339638906 |
235 | E>K | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA20232127 rs143147870 |
235 | E>Q | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA20232129 rs1044732934 |
237 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA339639100 rs778448252 |
244 | T>K | No |
ClinGen ExAC gnomAD |
|
|
rs778448252 CA741186 |
244 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA20232140 rs905758883 |
248 | V>E | No |
ClinGen TOPMed |
|
|
CA741187 rs745493214 |
250 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339639194 rs1229934194 |
250 | R>W | No |
ClinGen gnomAD |
|
|
CA741190 rs376305813 |
257 | G>R | No |
ClinGen ESP ExAC gnomAD |
|
|
CA339639520 rs1186207791 |
260 | W>* | No |
ClinGen gnomAD |
|
|
CA339639554 rs748878726 |
263 | Y>C | No |
ClinGen gnomAD |
|
|
rs748878726 CA20232196 |
263 | Y>F | No |
ClinGen gnomAD |
|
|
rs780917159 CA741212 |
266 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1221231626 CA339639644 |
276 | K>M | No |
ClinGen gnomAD |
|
|
CA339639660 rs1282812339 |
278 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
rs147477953 CA20232214 |
279 | S>N | No |
ClinGen ESP |
|
|
CA741216 rs759646706 |
281 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs1256470189 CA339639678 |
281 | S>P | No |
ClinGen TOPMed |
|
|
CA741218 rs772280544 |
282 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA741217 rs772280544 |
282 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs966131156 CA20232220 |
283 | D>G | No |
ClinGen TOPMed |
|
|
rs142611772 CA741221 |
284 | A>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1264625812 CA339639756 |
288 | E>D | No |
ClinGen TOPMed |
|
|
CA741224 rs750936420 |
299 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs779490079 CA741226 |
301 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA339639944 rs751220552 |
302 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA339639947 rs1557586013 |
302 | R>Q | No |
ClinGen Ensembl |
|
|
rs1323817341 CA339640046 |
310 | E>K | No |
ClinGen gnomAD |
|
|
rs1557586065 CA339640116 |
315 | I>V | No |
ClinGen Ensembl |
|
|
rs1439083588 CA339640133 |
316 | T>S | No |
ClinGen gnomAD |
|
|
rs1293069920 CA339640174 |
319 | M>T | No |
ClinGen TOPMed |
|
|
CA741258 rs201830817 |
325 | V>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1277977631 CA339642249 |
335 | K>T | No |
ClinGen gnomAD |
|
|
rs763427890 CA741259 |
338 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1258114778 CA339642331 |
339 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
CA741260 rs766746942 |
342 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1557588210 CA339642390 |
345 | A>V | No |
ClinGen Ensembl |
|
|
rs1569966601 CA339642397 |
346 | A>G | No |
ClinGen Ensembl |
|
|
CA741278 rs774660942 |
353 | A>E | No |
ClinGen ExAC gnomAD |
|
|
CA741277 rs771329448 |
353 | A>T | No |
ClinGen ExAC |
|
|
CA339642468 rs1241995764 |
355 | I>V | No |
ClinGen TOPMed |
|
|
rs1041748687 CA339642490 |
358 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA20233521 rs901813678 |
358 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1041748687 CA20233515 |
358 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA20233527 rs997631218 |
361 | I>V | No |
ClinGen Ensembl |
|
|
CA741284 rs753549329 |
366 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA741283 rs763803879 |
366 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA339642547 rs1367126763 |
367 | A>P | No |
ClinGen gnomAD |
|
|
CA741285 rs761460031 |
370 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750324825 CA741287 |
373 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA20233552 rs1050463397 |
374 | D>E | No |
ClinGen Ensembl |
|
|
rs781227475 CA741289 |
376 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs777902230 CA741292 |
382 | D>G | No |
ClinGen ExAC gnomAD |
|
|
COSM1213171 rs1192544657 CA339642676 |
387 | R>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs771183851 CA741294 |
390 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771183851 CA339642693 |
390 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA741296 rs200647118 |
393 | E>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs776176152 CA741298 |
397 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs146452317 CA741297 |
397 | R>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1308450186 CA339642771 |
399 | G>E | No |
ClinGen gnomAD |
|
|
rs1372150829 CA339642813 |
405 | K>R | No |
ClinGen gnomAD |
|
|
rs1445804546 CA339642823 |
406 | W>* | No |
ClinGen gnomAD |
|
|
CA20233764 rs575320254 |
409 | P>Q | No |
ClinGen 1000Genomes |
|
|
CA741322 rs762668654 |
410 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs61781208 CA741323 |
414 | Y>H | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1410186346 CA339642885 |
416 | T>A | No |
ClinGen TOPMed |
|
|
CA741325 rs759533501 |
416 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA741326 rs764046370 |
423 | V>E | No |
ClinGen ExAC gnomAD |
|
|
CA20233778 rs199976589 |
428 | I>F | No |
ClinGen 1000Genomes |
|
|
rs758824898 CA741331 |
434 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339643009 rs1484267411 |
435 | T>N | No |
ClinGen TOPMed |
|
|
rs78401598 CA20233785 |
435 | T>P | No |
ClinGen Ensembl |
|
|
rs755594088 CA741334 |
437 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA741335 rs781572505 |
438 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs1268526933 CA339643029 |
438 | R>L | No |
ClinGen TOPMed |
|
|
CA20233788 rs923301947 |
439 | I>V | No |
ClinGen Ensembl |
|
|
rs1318678254 CA339643037 |
440 | P>S | No |
ClinGen gnomAD |
|
|
rs368733943 CA741336 |
442 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA741355 rs781676626 |
443 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA741357 rs371436737 |
447 | P>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA741356 rs753155978 |
447 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs770615175 CA20237162 |
451 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs778556583 CA741361 |
452 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs200540406 CA741364 |
453 | L>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs200540406 CA741362 COSM1502462 |
453 | L>V | lung [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
rs879033247 CA20237184 |
455 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs905837700 CA20237191 |
458 | R>C | No |
ClinGen TOPMed |
|
|
CA339643775 rs1405031975 COSM1667353 |
458 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA339643779 rs1405031975 |
458 | R>L | No |
ClinGen TOPMed |
|
|
CA741367 rs773475751 |
461 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763148386 CA741368 |
461 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751837372 CA741370 |
464 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA339643850 rs1350462006 |
464 | N>S | No |
ClinGen gnomAD |
|
|
CA741372 rs767828400 |
469 | L>M | No |
ClinGen ExAC gnomAD |
|
|
CA741373 rs753244013 |
474 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs756619132 CA741375 |
480 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA741374 rs756619132 |
480 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs183629101 CA741376 |
480 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA741380 rs771899555 |
491 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM908293 rs371877562 CA741381 |
491 | R>H | endometrium [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs371877562 CA339644175 |
491 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA339644171 rs771899555 |
491 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746947432 CA741382 |
492 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA339644196 rs1420050153 |
493 | V>L | No |
ClinGen TOPMed |
|
|
CA339644222 rs1163490761 |
495 | E>G | No |
ClinGen gnomAD |
|
|
rs1569984631 CA339644320 |
505 | Y>S | No |
ClinGen Ensembl |
|
|
CA339644339 rs1557592834 |
507 | P>S | No |
ClinGen Ensembl |
|
|
COSM4143805 CA339644359 COSM4143803 rs1370325812 |
508 | Q>H | thyroid [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA339644367 rs1411051486 |
509 | P>H | No |
ClinGen gnomAD |
|
|
rs1411051486 CA339644370 |
509 | P>L | No |
ClinGen gnomAD |
2 associated diseases with P06239
[MIM: 615758]: Immunodeficiency 22 (IMD22)
A primary immunodeficiency characterized by T-cell dysfunction. Affected individuals present with lymphopenia, recurrent infections, severe diarrhea, and failure to thrive. {ECO:0000269|PubMed:22985903}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A primary immunodeficiency characterized by T-cell dysfunction. Affected individuals present with lymphopenia, recurrent infections, severe diarrhea, and failure to thrive. {ECO:0000269|PubMed:22985903}. Note=The disease is caused by variants affecting the gene represented in this entry.
9 regional properties for P06239
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 245 - 498 | IPR000719 |
| domain | SH2 domain | 125 - 224 | IPR000980 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 245 - 493 | IPR001245 |
| domain | SH3 domain | 61 - 121 | IPR001452 |
| active_site | Tyrosine-protein kinase, active site | 360 - 372 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 251 - 273 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 245 - 494 | IPR020635 |
| domain | Lck, SH3 domain | 65 - 118 | IPR035749 |
| domain | Tyrosine-protein kinase Lck, SH2 domain | 123 - 223 | IPR035850 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.2 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | PTHR24418 | TYROSINE-PROTEIN KINASE |
| PANTHER Subfamily | PTHR24418:SF39 | TYROSINE-PROTEIN KINASE LCK |
| PANTHER Protein Class | non-receptor tyrosine protein kinase | |
| PANTHER Pathway Category |
Parkinson disease Src kinase T cell activation Lck |
|
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| immunological synapse | An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| pericentriolar material | A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
19 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| CD4 receptor binding | Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages. |
| CD8 receptor binding | Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes. |
| identical protein binding | Binding to an identical protein or proteins. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. |
| phosphatidylinositol 3-kinase binding | Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. |
| phospholipase activator activity | Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. |
| phospholipase binding | Binding to a phospholipase. |
| phosphotyrosine residue binding | Binding to a phosphorylated tyrosine residue within a protein. |
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein phosphatase binding | Binding to a protein phosphatase. |
| protein serine/threonine phosphatase activity | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| SH2 domain binding | Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| T cell receptor binding | Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells. |
23 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of cysteine-type endopeptidase activity involved in apoptotic process | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. |
| B cell receptor signaling pathway | The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cellular zinc ion homeostasis | Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell. |
| hemopoiesis | The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| leukocyte migration | The movement of a leukocyte within or between different tissues and organs of the body. |
| peptidyl-tyrosine phosphorylation | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
| platelet activation | A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. |
| positive regulation of heterotypic cell-cell adhesion | Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion. |
| positive regulation of intrinsic apoptotic signaling pathway | Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. |
| positive regulation of leukocyte cell-cell adhesion | Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion. |
| positive regulation of T cell activation | Any process that activates or increases the frequency, rate or extent of T cell activation. |
| positive regulation of T cell receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of lymphocyte activation | Any process that modulates the frequency, rate or extent of lymphocyte activation. |
| release of sequestered calcium ion into cytosol | The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| T cell costimulation | The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. |
| T cell differentiation | The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. |
| T cell receptor signaling pathway | The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
90 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0JNB0 | FYN | Tyrosine-protein kinase Fyn | Bos taurus (Bovine) | SS |
| Q0VBZ0 | CSK | Tyrosine-protein kinase CSK | Bos taurus (Bovine) | SS |
| Q3ZC95 | BTK | Tyrosine-protein kinase | Bos taurus (Bovine) | EV SS |
| P41239 | CSK | Tyrosine-protein kinase CSK | Gallus gallus (Chicken) | SS |
| P00523 | SRC | Proto-oncogene tyrosine-protein kinase Src | Gallus gallus (Chicken) | EV |
| Q02977 | YRK | Proto-oncogene tyrosine-protein kinase Yrk | Gallus gallus (Chicken) | SS |
| Q8JH64 | BTK | Tyrosine-protein kinase BTK | Gallus gallus (Chicken) | SS |
| P09324 | YES1 | Tyrosine-protein kinase Yes | Gallus gallus (Chicken) | SS |
| Q05876 | FYN | Tyrosine-protein kinase Fyn | Gallus gallus (Chicken) | SS |
| Q75R65 | JAK2 | Tyrosine-protein kinase JAK2 | Gallus gallus (Chicken) | SS |
| P42683 | LCK | Proto-oncogene tyrosine-protein kinase LCK | Gallus gallus (Chicken) | SS |
| Q24592 | hop | Tyrosine-protein kinase hopscotch | Drosophila melanogaster (Fruit fly) | PR |
| P08630 | Btk | Tyrosine-protein kinase Btk | Drosophila melanogaster (Fruit fly) | SS |
| Q9V9J3 | Src42A | Tyrosine-protein kinase Src42A | Drosophila melanogaster (Fruit fly) | SS |
| P00528 | Src64B | Tyrosine-protein kinase Src64B | Drosophila melanogaster (Fruit fly) | SS |
| P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Homo sapiens (Human) | SS |
| O60674 | JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens (Human) | EV |
| P52333 | JAK3 | Tyrosine-protein kinase JAK3 | Homo sapiens (Human) | SS |
| P29597 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | Homo sapiens (Human) | EV |
| P43405 | SYK | Tyrosine-protein kinase SYK | Homo sapiens (Human) | EV |
| P43403 | ZAP70 | Tyrosine-protein kinase ZAP-70 | Homo sapiens (Human) | EV |
| Q13882 | PTK6 | Protein-tyrosine kinase 6 | Homo sapiens (Human) | EV |
| P09769 | FGR | Tyrosine-protein kinase Fgr | Homo sapiens (Human) | SS |
| P07948 | LYN | Tyrosine-protein kinase Lyn | Homo sapiens (Human) | SS |
| P06241 | FYN | Tyrosine-protein kinase Fyn | Homo sapiens (Human) | SS |
| P12931 | SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (Human) | EV |
| P51451 | BLK | Tyrosine-protein kinase Blk | Homo sapiens (Human) | SS |
| P08631 | HCK | Tyrosine-protein kinase HCK | Homo sapiens (Human) | EV |
| P07947 | YES1 | Tyrosine-protein kinase Yes | Homo sapiens (Human) | SS |
| P42685 | FRK | Tyrosine-protein kinase FRK | Homo sapiens (Human) | EV |
| Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Homo sapiens (Human) | EV |
| Q06187 | BTK | Tyrosine-protein kinase BTK | Homo sapiens (Human) | EV |
| P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Homo sapiens (Human) | SS |
| P42680 | TEC | Tyrosine-protein kinase Tec | Homo sapiens (Human) | SS |
| P42679 | MATK | Megakaryocyte-associated tyrosine-protein kinase | Homo sapiens (Human) | SS |
| P41240 | CSK | Tyrosine-protein kinase CSK | Homo sapiens (Human) | SS |
| Q14289 | PTK2B | Protein-tyrosine kinase 2-beta | Homo sapiens (Human) | PR |
| Q05397 | PTK2 | Focal adhesion kinase 1 | Homo sapiens (Human) | EV |
| Q13470 | TNK1 | Non-receptor tyrosine-protein kinase TNK1 | Homo sapiens (Human) | PR |
| Q07912 | TNK2 | Activated CDC42 kinase 1 | Homo sapiens (Human) | EV |
| P16591 | FER | Tyrosine-protein kinase Fer | Homo sapiens (Human) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P42684 | ABL2 | Tyrosine-protein kinase ABL2 | Homo sapiens (Human) | SS |
| P00519 | ABL1 | Tyrosine-protein kinase ABL1 | Homo sapiens (Human) | EV |
| Q9R117 | Tyk2 | Non-receptor tyrosine-protein kinase TYK2 | Mus musculus (Mouse) | SS |
| P08103 | Hck | Tyrosine-protein kinase HCK | Mus musculus (Mouse) | SS |
| P16277 | Blk | Tyrosine-protein kinase Blk | Mus musculus (Mouse) | SS |
| Q62270 | Srms | Tyrosine-protein kinase Srms | Mus musculus (Mouse) | SS |
| Q64434 | Ptk6 | Protein-tyrosine kinase 6 | Mus musculus (Mouse) | SS |
| P05480 | Src | Proto-oncogene tyrosine-protein kinase Src | Mus musculus (Mouse) | EV |
| P14234 | Fgr | Tyrosine-protein kinase Fgr | Mus musculus (Mouse) | SS |
| P35991 | Btk | Tyrosine-protein kinase BTK | Mus musculus (Mouse) | EV |
| P41241 | Csk | Tyrosine-protein kinase CSK | Mus musculus (Mouse) | EV |
| P25911 | Lyn | Tyrosine-protein kinase Lyn | Mus musculus (Mouse) | EV |
| Q62137 | Jak3 | Tyrosine-protein kinase JAK3 | Mus musculus (Mouse) | SS |
| Q62120 | Jak2 | Tyrosine-protein kinase JAK2 | Mus musculus (Mouse) | EV |
| P24604 | Tec | Tyrosine-protein kinase Tec | Mus musculus (Mouse) | SS |
| Q04736 | Yes1 | Tyrosine-protein kinase Yes | Mus musculus (Mouse) | SS |
| P39688 | Fyn | Tyrosine-protein kinase Fyn | Mus musculus (Mouse) | SS |
| P52332 | Jak1 | Tyrosine-protein kinase JAK1 | Mus musculus (Mouse) | SS |
| Q03526 | Itk | Tyrosine-protein kinase ITK/TSK | Mus musculus (Mouse) | SS |
| P41242 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q922K9 | Frk | Tyrosine-protein kinase FRK | Mus musculus (Mouse) | SS |
| P06240 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Mus musculus (Mouse) | SS |
| A1Y2K1 | FYN | Tyrosine-protein kinase Fyn | Sus scrofa (Pig) | SS |
| O19064 | JAK2 | Tyrosine-protein kinase JAK2 | Sus scrofa (Pig) | SS |
| Q62662 | Frk | Tyrosine-protein kinase FRK | Rattus norvegicus (Rat) | SS |
| Q62844 | Fyn | Tyrosine-protein kinase Fyn | Rattus norvegicus (Rat) | SS |
| Q07014 | Lyn | Tyrosine-protein kinase Lyn | Rattus norvegicus (Rat) | SS |
| P50545 | Hck | Tyrosine-protein kinase HCK | Rattus norvegicus (Rat) | SS |
| Q9WUD9 | Src | Proto-oncogene tyrosine-protein kinase Src | Rattus norvegicus (Rat) | SS |
| Q6P6U0 | Fgr | Tyrosine-protein kinase Fgr | Rattus norvegicus (Rat) | SS |
| Q62689 | Jak2 | Tyrosine-protein kinase JAK2 | Rattus norvegicus (Rat) | SS |
| Q63272 | Jak3 | Tyrosine-protein kinase JAK3 | Rattus norvegicus (Rat) | SS |
| P32577 | Csk | Tyrosine-protein kinase CSK | Rattus norvegicus (Rat) | SS |
| P41243 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Rattus norvegicus (Rat) | SS |
| F1LM93 | Yes1 | Tyrosine-protein kinase Yes | Rattus norvegicus (Rat) | SS |
| Q01621 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Rattus norvegicus (Rat) | SS |
| G5ECJ6 | csk-1 | Tyrosine-protein kinase csk-1 | Caenorhabditis elegans | SS |
| O45539 | src-2 | Tyrosine protein-kinase src-2 | Caenorhabditis elegans | SS |
| G5EE56 | src-1 | Tyrosine protein-kinase src-1 | Caenorhabditis elegans | SS |
| F4JTP5 | STY46 | Serine/threonine-protein kinase STY46 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22558 | STY8 | Serine/threonine-protein kinase STY8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q2MHE4 | HT1 | Serine/threonine/tyrosine-protein kinase HT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWL6 | STY17 | Serine/threonine-protein kinase STY17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A1A5H8 | yes1 | Tyrosine-protein kinase yes | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F1RDG9 | fynb | Tyrosine-protein kinase fynb | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O12990 | jak1 | Tyrosine-protein kinase JAK1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q1JPZ3 | src | Proto-oncogene tyrosine-protein kinase Src | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6EWH2 | fyna | Tyrosine-protein kinase fyna | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGCGCSSHPE | DDWMENIDVC | ENCHYPIVPL | DGKGTLLIRN | GSEVRDPLVT | YEGSNPPASP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LQDNLVIALH | SYEPSHDGDL | GFEKGEQLRI | LEQSGEWWKA | QSLTTGQEGF | IPFNFVAKAN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLEPEPWFFK | NLSRKDAERQ | LLAPGNTHGS | FLIRESESTA | GSFSLSVRDF | DQNQGEVVKH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YKIRNLDNGG | FYISPRITFP | GLHELVRHYT | NASDGLCTRL | SRPCQTQKPQ | KPWWEDEWEV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PRETLKLVER | LGAGQFGEVW | MGYYNGHTKV | AVKSLKQGSM | SPDAFLAEAN | LMKQLQHQRL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VRLYAVVTQE | PIYIITEYME | NGSLVDFLKT | PSGIKLTINK | LLDMAAQIAE | GMAFIEERNY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IHRDLRAANI | LVSDTLSCKI | ADFGLARLIE | DNEYTAREGA | KFPIKWTAPE | AINYGTFTIK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SDVWSFGILL | TEIVTHGRIP | YPGMTNPEVI | QNLERGYRMV | RPDNCPEELY | QLMRLCWKER |
| 490 | 500 | ||||
| PEDRPTFDYL | RSVLEDFFTA | TEGQYQPQP |