AiPD: Autoinhibited Protein Database

P05771

Gene name	PRKCB (PKCB, PRKCB1)
Protein name	Protein kinase C beta type
Names	PKC-B, PKC-beta
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5579
EC number	2.7.11.13: Protein-serine/threonine kinases
Protein Class

Descriptions

PRKCB encodes for Protein kinase C (PKC) beta type belongs to the PCKs family, is involved in various cellular processes, including cell growth, immune response, muscle contraction, and synaptic plasticity. The well-known autoinhibitory region of PKC family is the pseudosubstrate sequence, which directly interacts and blocks catalytic activity of the kinase domain. Subsequence to the pseudosubstrate site is the C1 domains (C1A and C1B, that bind diacylglycerol (DAG)), and C2 domain (bind anionic phospholipids in a Ca2+-dependent manner). C1a (residues 36-88) domain coordinates a network of domain-domain intramolecular interactions, including direct C1a-C2 contacts. The pseudosubstrate and C1a domains operate as a single functional unit and is necessary to maintain autoinhibition. Additionally, in the absence of the C1a domain there is a significant increase in basal activity.

Autoinhibitory domains (AIDs)

19-36 (Pseudosubstrate site) SS

Target domain	341-664 (Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha)
Relief mechanism	Ligand binding
Assay

AID

19-36 (Pseudosubstrate site)

Target domain

341-664 (Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha)

Relief mechanism

Ligand binding (Binding of anionic phospholipids to the C2 domain)

Assay

Accessory elements

483-506 (Activation loop from InterPro)

Target domain	341-664 (Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta)
Relief mechanism
Assay

References

Sommese RF et al. (2017) "The Role of Regulatory Domains in Maintaining Autoinhibition in the Multidomain Kinase PKCα", The Journal of biological chemistry, 292, 2873-2880

Mosior M et al. (1991) "Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes", Biophysical journal, 60, 149-59

Bichsel SJ et al. (2004) "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein", The Journal of biological chemistry, 279, 35228-35

Stegert MR et al. (2004) "Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein", The Journal of biological chemistry, 279, 23806-12

Truebestein L et al. (2021) "Structure of autoinhibited Akt1 reveals mechanism of PIP(3)-mediated activation", Proceedings of the National Academy of Sciences of the United States of America, 118,

Lučić I et al. (2018) "Conformational sampling of membranes by Akt controls its activation and inactivation", Proceedings of the National Academy of Sciences of the United States of America, 115, E3940-E3949

Huang X et al. (2003) "Crystal structure of an inactive Akt2 kinase domain", Structure (London, England : 1993), 11, 21-30

Steinberg SF (2008) "Structural basis of protein kinase C isoform function", Physiological reviews, 88, 1341-78

Pears CJ et al. (1990) "Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation", European journal of biochemistry, 194, 89-94

Smith MK et al. (1990) "Specificities of autoinhibitory domain peptides for four protein kinases. Implications for intact cell studies of protein kinase function", The Journal of biological chemistry, 265, 1837-40

Yoshinaga C et al. (1999) "Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain", Journal of biochemistry, 126, 475-84

Ivey RA et al. (2014) "Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO₄)₃-dependent activation of atypical PKC", The Journal of biological chemistry, 289, 25021-30

Masters TA et al. (2010) "Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells", Science signaling, 3, ra78

Slater SJ et al. (2002) "Regulation of PKC alpha activity by C1-C2 domain interactions", The Journal of biological chemistry, 277, 15277-85

Jones AC et al. (2020) "Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes", IUBMB life, 72, 2584-2590

Kirwan AF et al. (2003) "Inhibition of protein kinase C catalytic activity by additional regions within the human protein kinase Calpha-regulatory domain lying outside of the pseudosubstrate sequence", The Biochemical journal, 373, 571-81

Autoinhibited structure

Activated structure

2 structures for P05771

Entry ID	Method	Resolution	Chain	Position	Source
2I0E	X-ray	260 A	A/B	321-671	PDB
AF-P05771-F1	Predicted				AlphaFoldDB

322 variants for P05771

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1290205152 CA395267074	3	D>E		No	ClinGen gnomAD
CA279852430 rs1012485614	4	P>A		No	ClinGen TOPMed
CA7966078 rs757085223	4	P>R		No	ClinGen ExAC gnomAD
CA7966079 rs201366670	5	A>D		No	ClinGen 1000Genomes ExAC gnomAD
CA7966080 rs201366670	5	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA395267089 rs1269979183	6	A>V		No	ClinGen gnomAD
rs781362818 CA7966082	8	P>Q		No	ClinGen ExAC gnomAD
CA7966084 rs368093414	9	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs575795787 CA7966083	9	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA395267110 rs1425263935	10	P>L		No	ClinGen gnomAD
CA395267107 rs1384528118	10	P>S		No	ClinGen gnomAD
rs370984906 CA7966085	12	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA7966086 rs749669754	13	G>D		No	ClinGen ExAC gnomAD
CA395267134 rs1243136292	14	E>G		No	ClinGen gnomAD
rs771388864 CA7966087	14	E>K		No	ClinGen ExAC gnomAD
rs1313793731 CA395267138	15	E>K		No	ClinGen TOPMed gnomAD
CA395267151 rs1359470631	16	S>I		No	ClinGen TOPMed
rs773819749 CA7966088	17	T>I		No	ClinGen ExAC gnomAD
CA7966089 rs759234204	19	R>H		No	ClinGen ExAC gnomAD
CA7966090 rs766899029	20	F>L		No	ClinGen ExAC gnomAD
CA395267177 rs1195385839	21	A>T		No	ClinGen gnomAD
CA279852431 rs200442462	22	R>H		No	ClinGen 1000Genomes
CA7966092 rs760228327	24	G>R		No	ClinGen ExAC gnomAD
CA395267215 rs1378724342	27	R>Q		No	ClinGen TOPMed
rs1461287415 CA395267228	29	K>E		No	ClinGen gnomAD
rs1401988911 CA395267255	32	H>Q		No	ClinGen gnomAD
rs1335436295 CA395267281	36	N>S		No	ClinGen gnomAD
CA395267368 rs1315454019	48	T>P		No	ClinGen gnomAD
CA395267384 rs1325263692	50	C>S		No	ClinGen gnomAD
rs1227144603 CA395267394	51	S>R		No	ClinGen gnomAD
rs1259154481 CA395267400	52	H>R		No	ClinGen gnomAD
CA395267476 rs1405456160	61	G>R		No	ClinGen TOPMed gnomAD
rs1405456160 CA395267477	61	G>R		No	ClinGen TOPMed gnomAD
rs866469671 CA279852558	64	G>R		No	ClinGen Ensembl
rs868688793 CA279852559	67	C>*		No	ClinGen Ensembl
CA395267526 rs1329943455	68	Q>K		No	ClinGen TOPMed
rs1221180009 CA395267531	68	Q>R		No	ClinGen gnomAD
rs1002043513 CA279869892	69	V>A		No	ClinGen Ensembl
CA7966157 rs370311602	70	C>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1033653376 CA279869893	71	C>S		No	ClinGen Ensembl
rs1161207000 CA395267584	74	V>M		No	ClinGen TOPMed
COSM183574 rs1420866853 CA395267607	77	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs371650623 CA7966162	89	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs750901145 CA7966163 COSM702952	90	D>V	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA395267714 rs1131692056 RCV000495853	92	G>V		No	ClinGen ClinVar TOPMed dbSNP
rs755399339 CA7966167	96	D>G		No	ClinGen ExAC gnomAD
rs751886977 CA7966166 COSM3420875	96	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs751886977 CA395267733	96	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA395268121 rs777534524	97	D>A		No	ClinGen ExAC gnomAD
rs777534524 CA7966188	97	D>G		No	ClinGen ExAC gnomAD
rs949678733 CA279875192	97	D>H		No	ClinGen Ensembl
CA279875193 rs953633182	98	P>L		No	ClinGen TOPMed gnomAD
rs867672863 CA279875194	99	R>C		No	ClinGen TOPMed
COSM1581526 rs748776658 CA7966189	99	R>H	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs3729895 CA279875195	100	S>I		No	ClinGen Ensembl
rs1330128361 CA395268187	107	H>N		No	ClinGen gnomAD
CA7966191 rs778983154	108	T>M		No	ClinGen ExAC gnomAD
rs1187190929 CA395268209	110	S>A		No	ClinGen TOPMed
CA395268234 rs1422286381	113	T>M		No	ClinGen TOPMed
CA7966196 rs769874764	123	Y>C		No	ClinGen ExAC gnomAD
rs1567351049 CA395268320	126	I>V		No	ClinGen Ensembl
CA7966197 rs773546270	129	G>W		No	ClinGen ExAC gnomAD
rs1464237364 CA395268376	133	D>V		No	ClinGen TOPMed
CA395268397 rs1181680133	134	T>N		No	ClinGen gnomAD
rs1287445567 CA395268411	136	M>T		No	ClinGen TOPMed
CA7966220 rs759666193	136	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1458204649 CA395268423	137	M>I		No	ClinGen gnomAD
rs1164845499 CA395268425	138	N>D		No	ClinGen gnomAD
CA7966221 rs772430325	138	N>T		No	ClinGen ExAC TOPMed gnomAD
rs550043137 CA7966222	142	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7966224 VAR_042304 rs764534677	144	V>M	a colorectal adenocarcinoma sample; somatic mutation [UniProt]	No	ClinGen UniProt ExAC dbSNP gnomAD
CA395268474 rs1449586522	145	M>L		No	ClinGen gnomAD
rs1296566556 CA395268485	146	N>S		No	ClinGen TOPMed
CA7966227 rs765028943	153	T>M		No	ClinGen ExAC gnomAD
CA395268553 rs1316243902	156	T>M		No	ClinGen gnomAD
CA7966230 rs779838345	158	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7966231 rs751524971	158	R>H		No	ClinGen ExAC TOPMed gnomAD
CA395268563 rs779838345	158	R>S		No	ClinGen ExAC TOPMed gnomAD
rs754659392 CA7966232	159	R>C		No	ClinGen ExAC
rs923149142 CA279875560	159	R>H		No	ClinGen Ensembl
CA395268577 COSM1222018 rs1309122797	161	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
COSM471510 rs1260666109 CA395268580	161	R>H	kidney large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA395268589 rs749465077	162	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1424365930 CA395268594	163	Y>C		No	ClinGen gnomAD
rs199648786 CA7966235	165	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1209574685 CA395268609	165	Q>P		No	ClinGen TOPMed
rs1209574685 CA395268607	165	Q>R		No	ClinGen TOPMed
CA395268634 rs1402100403	169	D>H		No	ClinGen TOPMed gnomAD
CA395268633 rs1402100403	169	D>N		No	ClinGen TOPMed gnomAD
rs115645964 CA395268655	171	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1467773856 CA395268648	171	D>N		No	ClinGen gnomAD
CA7966238 rs200811816	172	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs775803818 CA7966239	174	I>V		No	ClinGen ExAC gnomAD
CA395268685 rs1341304897	177	V>I		No	ClinGen TOPMed
CA395141692 rs1312864471	178	R>G		No	ClinGen gnomAD
rs1029252769 CA279551656	178	R>T		No	ClinGen Ensembl
rs1289265896 CA395141707	179	D>V		No	ClinGen TOPMed
rs779094238 CA7966254	179	D>Y		No	ClinGen ExAC gnomAD
CA395141740 rs1352952043	182	N>I		No	ClinGen gnomAD
rs573366163 CA279551668	184	V>L		No	ClinGen Ensembl
rs1487278717 CA395141814	189	N>S		No	ClinGen TOPMed gnomAD
rs747105951 CA7966258	196	V>I		No	ClinGen ExAC gnomAD
rs748510627 CA7966261	201	I>F		No	ClinGen ExAC
rs770291872 CA7966262	201	I>T		No	ClinGen ExAC gnomAD
rs1315933785 CA395141945	202	P>S		No	ClinGen TOPMed
CA395141951 rs1362878097 COSM968877	203	D>N	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA395141995 rs1434512195	206	S>I		No	ClinGen gnomAD
CA279551754 rs917317004	211	K>N		No	ClinGen TOPMed
rs773891890 CA7966266	214	T>A		No	ClinGen ExAC gnomAD
rs1307237817 CA395142973	226	T>R		No	ClinGen gnomAD
CA279552706 rs200005518	230	Q>E		No	ClinGen Ensembl
CA395143253 rs1403164399	233	E>A		No	ClinGen TOPMed
rs770589472 CA7966283	234	S>L		No	ClinGen ExAC TOPMed gnomAD
CA395143551 rs1466408302	253	N>Y		No	ClinGen TOPMed
rs1242956750 CA395143634	259	L>M		No	ClinGen TOPMed
rs777404333 CA7966291	266	L>V		No	ClinGen ExAC gnomAD
CA279552756 rs756684442 COSM183610	269	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs751743022 CA7966293	271	V>A		No	ClinGen ExAC gnomAD
rs745475837 CA7966320	276	K>R		No	ClinGen ExAC gnomAD
CA395147038 rs1276462315	279	S>N		No	ClinGen TOPMed
rs1350730209 CA395147140	287	N>S		No	ClinGen TOPMed gnomAD
rs1195602382 CA395147190	292	P>S		No	ClinGen gnomAD
CA7966325 rs199901715	294	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1451619049 CA395147210	294	G>R		No	ClinGen gnomAD
CA279564380 rs998179536	295	S>R		No	ClinGen Ensembl
rs1173277247 CA395147243	298	N>D		No	ClinGen TOPMed gnomAD
rs147975795 CA7966327	298	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7966329 rs762879227	302	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs536939564 CA395147272	302	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs999756092 CA279564426 COSM379883	303	Q>K	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1392134777 CA395147279	303	Q>L		No	ClinGen gnomAD
CA395147289 rs1321164467	304	K>N		No	ClinGen gnomAD
rs141851225 CA279572594	307	R>T		No	ClinGen ESP TOPMed
CA7966353 rs760838283	308	A>D		No	ClinGen ExAC gnomAD
rs764189258 CA7966354	310	I>V		No	ClinGen ExAC gnomAD
rs866640642 CA279572607	313	G>E		No	ClinGen Ensembl
CA395148276 rs1377518552	314	T>A		No	ClinGen TOPMed
CA395148282 rs1456492346	315	K>E		No	ClinGen gnomAD
rs749777388 CA279572628	316	V>I		No	ClinGen Ensembl
CA7966357 rs202044032 COSM1222020	317	P>L	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA395148304 rs1465185956	318	E>A		No	ClinGen TOPMed gnomAD
CA395148324 rs1185075927	321	T>A		No	ClinGen gnomAD
CA7966359 rs139055681	321	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7966361 rs751175487	322	T>A		No	ClinGen ExAC TOPMed gnomAD
CA7966362 rs754563290	322	T>I		No	ClinGen ExAC TOPMed gnomAD
CA395148333 rs1464644193	323	N>D		No	ClinGen gnomAD
rs1331485957 CA395148341	324	T>A		No	ClinGen gnomAD
rs1331485957 CA395148340	324	T>P		No	ClinGen gnomAD
rs1442138562 CA395148344	324	T>S		No	ClinGen TOPMed
rs755710261 CA7966365	326	S>F		No	ClinGen ExAC gnomAD
rs749243156 CA7966367	327	K>R		No	ClinGen ExAC gnomAD
rs778877195 CA395148386	330	N>K		No	ClinGen ExAC TOPMed gnomAD
CA7966369 rs778877195	330	N>K		No	ClinGen ExAC TOPMed gnomAD
CA395148388 rs1251985265	331	N>D		No	ClinGen TOPMed gnomAD
CA395148389 rs1251985265	331	N>Y		No	ClinGen TOPMed gnomAD
rs149128755 CA7966370	332	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA279572725 rs1027953347	334	R>S		No	ClinGen TOPMed
CA395148425 rs1163412779 COSM1263067	336	R>Q	oesophagus large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs768732945 CA7966371	336	R>W		No	ClinGen ExAC TOPMed gnomAD
rs776981512 CA7966372	340	T>P		No	ClinGen ExAC TOPMed gnomAD
CA395148450 rs1243515236	340	T>S		No	ClinGen TOPMed
rs1189884717 CA395148455	341	D>Y		No	ClinGen gnomAD
rs763468825 CA7966376	346	M>I		No	ClinGen ExAC gnomAD
CA395148491 rs773665394	346	M>L		No	ClinGen ExAC gnomAD
CA7966375 rs773665394	346	M>V		No	ClinGen ExAC gnomAD
CA7966377 rs766920124	347	V>L		No	ClinGen ExAC gnomAD
COSM968889 CA395148497 rs766920124	347	V>M	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA395148531 rs1419773626	352	S>T		No	ClinGen TOPMed
rs1306990794 CA395147428	357	M>L		No	ClinGen gnomAD
CA279552339 rs868712349	361	R>Q		No	ClinGen gnomAD
rs758085883 CA7966405	362	K>R		No	ClinGen ExAC
rs148312044 CA7966407	364	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA395147566 rs1567394482	365	D>G		No	ClinGen Ensembl
rs141758720 CA279552362	369	A>T		No	ClinGen ESP
rs1196283226 CA395147685	373	L>M		No	ClinGen gnomAD
rs1158950782 CA395147722	377	V>I		No	ClinGen TOPMed gnomAD
rs1382022679 COSM1518675 CA395147728	378	V>M	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
CA279552377 rs866023052	383	D>N		No	ClinGen Ensembl
rs200238437 CA395147772	384	V>L		No	ClinGen TOPMed gnomAD
CA279552383 rs200238437	384	V>M		No	ClinGen TOPMed gnomAD
CA395147793 rs1158042315	387	T>P		No	ClinGen TOPMed
CA395147805 rs1398645091	388	M>I		No	ClinGen TOPMed
rs746420133 CA7966413	388	M>L		No	ClinGen ExAC gnomAD
rs746420133 CA395147799	388	M>V		No	ClinGen ExAC gnomAD
CA279552388 rs267604474	390	E>K		No	ClinGen Ensembl
rs772277246 CA7966414	391	K>R		No	ClinGen ExAC gnomAD
rs775901586 CA7966415	392	R>Q		No	ClinGen ExAC gnomAD
rs1596572437 CA395147834	393	V>G		No	ClinGen Ensembl
CA7966416 rs761166216	393	V>L		No	ClinGen ExAC TOPMed gnomAD
CA395147832 rs761166216	393	V>M		No	ClinGen ExAC TOPMed gnomAD
CA7966417 rs763837460	395	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1382781957 CA395147861	398	G>R		No	ClinGen TOPMed
COSM2155834 CA7966420 rs764831474	400	P>L	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA395147883 rs1216229559	401	P>L		No	ClinGen gnomAD
rs1304686434 CA395147892	403	L>V		No	ClinGen gnomAD
rs1256893339 CA395147909	405	Q>H		No	ClinGen gnomAD
CA7966423 rs766266252	407	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1205851470 CA395147955	412	T>A		No	ClinGen gnomAD
CA7966424 rs369508594	413	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201855972 CA7966425	413	M>R		No	ClinGen 1000Genomes ExAC gnomAD
rs369508594 CA395147960	413	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1281418911 CA395150412	415	R>C		No	ClinGen gnomAD
rs1016918004 CA279559765	415	R>H		No	ClinGen TOPMed
rs1350481952 CA395150423	417	Y>C		No	ClinGen gnomAD
CA395150429 rs1567401110	418	F>L		No	ClinGen Ensembl
rs754699676 CA7966444	421	E>D		No	ClinGen ExAC gnomAD
CA395150468 rs1447848733	423	V>L		No	ClinGen gnomAD
rs1396885380 CA395150542	433	Q>R		No	ClinGen gnomAD
rs989971389 CA279559802	434	Q>L		No	ClinGen TOPMed gnomAD
rs1360641057 CA395150559	436	G>S		No	ClinGen TOPMed
rs750515509 CA7966450	437	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA395150570 rs1402118615	438	F>L		No	ClinGen gnomAD
CA395150595 rs1320943482	441	P>S		No	ClinGen TOPMed gnomAD
CA395150593 rs1320943482	441	P>T		No	ClinGen TOPMed gnomAD
CA7966451 rs758468877	442	H>Y		No	ClinGen ExAC gnomAD
rs781780434 CA7966482	447	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1365302575 CA395150742	448	A>T		No	ClinGen TOPMed
CA7966483 rs748531840	450	I>V		No	ClinGen ExAC gnomAD
COSM1376870 CA7966486 rs748923188	453	G>S	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA395150932 rs1251234264	458	Q>H		No	ClinGen gnomAD
rs1439335396 CA395150946	459	S>T		No	ClinGen gnomAD
rs1448376098 CA395150966	460	K>R		No	ClinGen TOPMed gnomAD
rs370646498 CA279561096	461	G>D		No	ClinGen ESP
CA395152177 rs1476420163	469	L>F		No	ClinGen TOPMed
rs1371028158 CA395152187	470	D>E		No	ClinGen Ensembl
rs1003838471 CA279564760	472	V>M		No	ClinGen TOPMed gnomAD
CA395152211 rs1381692250	474	L>I		No	ClinGen gnomAD
CA395152217 rs1596585843	475	D>N		No	ClinGen Ensembl
CA7966508 rs775433458	477	E>D		No	ClinGen ExAC gnomAD
CA279564770 rs868580158 COSM1708978	483	A>V	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs768685403 CA7966510	488	C>F		No	ClinGen ExAC gnomAD
CA279564783 rs867836631	490	E>K		No	ClinGen Ensembl
rs761763038 CA7966512	495	G>A		No	ClinGen ExAC gnomAD
rs1205166450 CA395152374	496	V>G		No	ClinGen gnomAD
CA395152369 rs1466858740 VAR_042305	496	V>M	a glioblastoma multiforme sample; somatic mutation [UniProt]	No	ClinGen UniProt TOPMed dbSNP
rs111341519 CA279564825	500	T>K		No	ClinGen Ensembl
rs766692518 CA7966513	503	G>S		No	ClinGen ExAC
rs1395078294 CA395153538	514	A>S		No	ClinGen gnomAD
rs751018138 CA7966543	514	A>V		No	ClinGen ExAC gnomAD
CA395153578 rs1210146222	517	P>S		No	ClinGen TOPMed
rs1391826679 CA395153646	522	V>M		No	ClinGen gnomAD
rs1304281427 CA395153798	532	Y>C		No	ClinGen TOPMed
rs1232096306 CA395153826	534	M>V		No	ClinGen gnomAD
rs769663948 CA7966547	537	G>V		No	ClinGen ExAC gnomAD
rs1205615783 COSM968910 CA395153955	539	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA279567959 rs866115382	544	E>K		No	ClinGen Ensembl
CA395154124 rs1258568565	551	Q>H		No	ClinGen gnomAD
CA7966566 rs749084012	553	I>V		No	ClinGen ExAC gnomAD
rs1567405700 CA395154160	554	M>T		No	ClinGen Ensembl
CA7966568 rs780076694	557	N>T		No	ClinGen ExAC gnomAD
rs1460808228 CA395154229	558	V>A		No	ClinGen TOPMed
rs368238909 CA7966570	558	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA7966571 rs17847879	563	S>P		No	ClinGen 1000Genomes ExAC gnomAD
rs761943712 CA7966572	568	A>T		No	ClinGen ExAC gnomAD
CA7966573 rs770267855	569	V>M		No	ClinGen ExAC gnomAD
rs1269111297 CA395154372	571	I>F		No	ClinGen gnomAD
CA395154377 rs1269111297	571	I>V		No	ClinGen gnomAD
rs1188905206 CA395154407	573	K>Q		No	ClinGen Ensembl
CA7966589 rs201555288	575	L>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1280319280 CA395154674	576	M>T		No	ClinGen gnomAD
rs769865916 CA7966590	579	H>L		No	ClinGen ExAC gnomAD
rs1312216413 CA395154706	581	G>S		No	ClinGen TOPMed gnomAD
CA279571460 rs868049690	583	R>C		No	ClinGen Ensembl
rs773667135 CA7966591	583	R>H		No	ClinGen ExAC gnomAD
rs1047623176 CA279571484	586	C>S		No	ClinGen gnomAD
CA395154749 rs1222298257	588	P>A		No	ClinGen TOPMed gnomAD
rs35631544 VAR_042306 CA7966592	588	P>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA279571497 rs35631544	588	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774746011 CA395154773	591	E>*		No	ClinGen ExAC TOPMed gnomAD
CA7966594 COSM1323638 rs774746011	591	E>K	ovary large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs767640161 COSM434948 CA7966595	592	R>C	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA7966596 rs767265943	592	R>H		No	ClinGen ExAC gnomAD
rs767265943 CA395154786	592	R>P		No	ClinGen ExAC gnomAD
rs775297421 CA7966597	593	D>G		No	ClinGen ExAC gnomAD
rs1270790873 CA395154824	596	E>Q		No	ClinGen TOPMed
CA7966599 rs114846751	598	A>T		No	ClinGen 1000Genomes ExAC
CA279571573 rs757200847	601	R>L		No	ClinGen ExAC TOPMed gnomAD
CA7966601 COSM417095 rs757200847	601	R>Q	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs753672328 CA7966600	601	R>W		No	ClinGen ExAC gnomAD
rs1458336023 CA395154901	603	I>L		No	ClinGen gnomAD
CA395154908 rs1162194025	603	I>T		No	ClinGen gnomAD
CA395154947 rs1324557619	606	E>K		No	ClinGen gnomAD
CA7966604 rs758199138	608	L>I		No	ClinGen ExAC gnomAD
CA7966605 rs781322629	610	R>C		No	ClinGen ExAC TOPMed gnomAD
COSM183635 rs563116744 CA7966606	610	R>H	large_intestine haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA395155019 rs1231980241	612	E>*		No	ClinGen Ensembl
CA279571601 rs371799088	617	Y>F		No	ClinGen ESP TOPMed
CA395155334 rs1271381082	621	A>G		No	ClinGen TOPMed gnomAD
CA7966608 rs777885939	621	A>T		No	ClinGen ExAC TOPMed gnomAD
CA395267756 rs1433661843	622	R>T		No	ClinGen TOPMed
rs1194130408 CA395267768	624	K>Q		No	ClinGen TOPMed
rs867995282 CA279881733	627	T>N		No	ClinGen Ensembl
rs1596606567 CA395267791	627	T>P		No	ClinGen Ensembl
rs773514796 CA7966708	629	N>H		No	ClinGen ExAC gnomAD
rs763241619 CA7966709	629	N>S		No	ClinGen ExAC TOPMed gnomAD
rs763241619 CA395267804	629	N>T		No	ClinGen ExAC TOPMed gnomAD
COSM1376882 CA395267818 rs1207487721	631	D>N	large_intestine central_nervous_system [Cosmic]	No	ClinGen cosmic curated TOPMed
CA7966712 rs759718537	636	R>G		No	ClinGen ExAC gnomAD
rs1345998316 CA395267865	637	Q>R		No	ClinGen TOPMed
rs1398402348 CA395267873	638	P>L		No	ClinGen gnomAD
CA395267887 rs767852403	640	E>D		No	ClinGen ExAC gnomAD
rs760907855 CA7966715	643	P>H		No	ClinGen ExAC gnomAD
rs1323202929 CA395267909	644	T>A		No	ClinGen TOPMed gnomAD
CA7966716 rs764466114	646	K>Q		No	ClinGen ExAC gnomAD
rs554313951 CA7966717	647	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756874692 CA7966718	649	I>M		No	ClinGen ExAC gnomAD
rs866828752 CA279881735	650	M>I		No	ClinGen Ensembl
rs1370033348 CA395267950	650	M>V		No	ClinGen gnomAD
CA395267958 rs1226609389	651	N>Y		No	ClinGen gnomAD
rs1329716375 CA395267975	653	D>G		No	ClinGen gnomAD
CA7966721 rs749890233	654	Q>H		No	ClinGen ExAC gnomAD
rs1252308357 COSM557403 CA395268012	658	A>S	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1186433316 CA395268041	662	Y>F		No	ClinGen gnomAD
CA7966722 rs779793250	663	T>A		No	ClinGen ExAC gnomAD
CA395268050 rs1199371749	664	N>D		No	ClinGen gnomAD
CA395268052 rs1248052567	664	N>S		No	ClinGen gnomAD
CA7966723 rs747003127	665	P>A		No	ClinGen ExAC gnomAD
rs142427207 CA7966724	665	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA279881736 rs1047305611	668	V>A		No	ClinGen Ensembl
rs781115157 CA395268083	669	I>F		No	ClinGen ExAC gnomAD
CA7966725 rs781115157	669	I>V		No	ClinGen ExAC gnomAD
CA395268096 rs1405090025	671	V>M		No	ClinGen TOPMed gnomAD

No associated diseases with P05771

13 regional properties for P05771

Type	Name	Position	InterPro Accession
domain	C2 domain	158 - 277	IPR000008
domain	Protein kinase domain	342 - 600	IPR000719
domain	AGC-kinase, C-terminal	601 - 671	IPR000961
domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	36 - 87	IPR002219-1
domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	101 - 153	IPR002219-2
active_site	Serine/threonine-protein kinase, active site	462 - 474	IPR008271
binding_site	Protein kinase, ATP binding site	348 - 371	IPR017441
domain	Protein kinase, C-terminal	624 - 662	IPR017892
domain	Diacylglycerol/phorbol-ester binding	34 - 48	IPR020454-1
domain	Diacylglycerol/phorbol-ester binding	50 - 59	IPR020454-2
domain	Diacylglycerol/phorbol-ester binding	63 - 74	IPR020454-3
domain	Diacylglycerol/phorbol-ester binding	140 - 152	IPR020454-4
domain	Classical protein kinase C beta, catalytic domain	341 - 664	IPR034664

Functions

		Description
EC Number	2.7.11.13	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Nucleus Membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
calyx of Held	The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynaptic cytosol	The region of the cytosol consisting of all cytosol that is part of the presynapse.
spectrin	Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.

14 GO annotations of molecular function

Name	Definition
androgen receptor binding	Binding to a nuclear androgen receptor.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium channel regulator activity	Modulates the activity of a calcium channel.
calcium-dependent protein kinase C activity	Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
histone kinase activity (H3-T6 specific)	Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3.
nuclear receptor coactivator activity	A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
protein kinase C activity	Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
protein kinase C binding	Binding to protein kinase C.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
zinc ion binding	Binding to a zinc ion (Zn).

26 GO annotations of biological process

Name	Definition
adaptive immune response	An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
B cell activation	The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
B cell receptor signaling pathway	The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
calcium ion transport	The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cellular calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
cellular response to carbohydrate stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone H3-T6 phosphorylation	OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipoprotein transport	The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
mitotic nuclear membrane disassembly	The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis.
negative regulation of glucose transmembrane transport	Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of insulin receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of angiogenesis	Any process that activates or increases angiogenesis.
positive regulation of B cell receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
positive regulation of I-kappaB kinase/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of NF-kappaB transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of vascular endothelial growth factor receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
presynaptic modulation of chemical synaptic transmission	Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of glucose transmembrane transport	Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of synaptic vesicle exocytosis	Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

40 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P24583	PKC1	Protein kinase C-like 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
P04409	PRKCA	Protein kinase C alpha type	Bos taurus (Bovine)	EV SS
P05128	PRKCG	Protein kinase C gamma type	Bos taurus (Bovine)	SS
P05126	PRKCB	Protein kinase C beta type	Bos taurus (Bovine)	SS
P13677	inaC	Protein kinase C, eye isozyme	Drosophila melanogaster (Fruit fly)	SS
P05130	Pkc53E	Protein kinase C, brain isozyme	Drosophila melanogaster (Fruit fly)	SS
O15530	PDPK1	3-phosphoinositide-dependent protein kinase 1	Homo sapiens (Human)	EV
Q05513	PRKCZ	Protein kinase C zeta type	Homo sapiens (Human)	SS
P41743	PRKCI	Protein kinase C iota type	Homo sapiens (Human)	EV
Q16512	PKN1	Serine/threonine-protein kinase N1	Homo sapiens (Human)	EV
Q6P5Z2	PKN3	Serine/threonine-protein kinase N3	Homo sapiens (Human)	SS
Q16513	PKN2	Serine/threonine-protein kinase N2	Homo sapiens (Human)	EV
P24723	PRKCH	Protein kinase C eta type	Homo sapiens (Human)	SS
Q02156	PRKCE	Protein kinase C epsilon type	Homo sapiens (Human)	SS
Q04759	PRKCQ	Protein kinase C theta type	Homo sapiens (Human)	PR
Q05655	PRKCD	Protein kinase C delta type	Homo sapiens (Human)	SS
P17252	PRKCA	Protein kinase C alpha type	Homo sapiens (Human)	EV
P05129	PRKCG	Protein kinase C gamma type	Homo sapiens (Human)	SS
P31751	AKT2	RAC-beta serine/threonine-protein kinase	Homo sapiens (Human)	EV SS
P31749	AKT1	RAC-alpha serine/threonine-protein kinase	Homo sapiens (Human)	EV
Q9Y243	AKT3	RAC-gamma serine/threonine-protein kinase	Homo sapiens (Human)	SS
Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	Homo sapiens (Human)	SS
Q9HBY8	SGK2	Serine/threonine-protein kinase Sgk2	Homo sapiens (Human)	SS
O00141	SGK1	Serine/threonine-protein kinase Sgk1	Homo sapiens (Human)	PR
Q15208	STK38	Serine/threonine-protein kinase 38	Homo sapiens (Human)	EV
Q9Y2H1	STK38L	Serine/threonine-protein kinase 38-like	Homo sapiens (Human)	EV
Q6A1A2	PDPK2P	Putative 3-phosphoinositide-dependent protein kinase 2	Homo sapiens (Human)	PR
P20444	Prkca	Protein kinase C alpha type	Mus musculus (Mouse)	SS
P63318	Prkcg	Protein kinase C gamma type	Mus musculus (Mouse)	SS
P68404	Prkcb	Protein kinase C beta type	Mus musculus (Mouse)	SS
P16054	Prkce	Protein kinase C epsilon type	Mus musculus (Mouse)	PR
P23298	Prkch	Protein kinase C eta type	Mus musculus (Mouse)	PR
P05696	Prkca	Protein kinase C alpha type	Rattus norvegicus (Rat)	SS
P63319	Prkcg	Protein kinase C gamma type	Rattus norvegicus (Rat)	SS
Q64617	Prkch	Protein kinase C eta type	Rattus norvegicus (Rat)	PR
P68403	Prkcb	Protein kinase C beta type	Rattus norvegicus (Rat)	SS
P90980	pkc-2	Protein kinase C-like 2	Caenorhabditis elegans	SS
Q9SUA3	D6PKL1	Serine/threonine-protein kinase D6PKL1	Arabidopsis thaliana (Mouse-ear cress)	PR
A8KBH6	prkcb	Protein kinase C beta type	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	SS
Q7SY24	prkcbb	Protein kinase C beta type	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MADPAAGPPP	SEGEESTVRF	ARKGALRQKN	VHEVKNHKFT	ARFFKQPTFC	SHCTDFIWGF
70	80	90	100	110	120
GKQGFQCQVC	CFVVHKRCHE	FVTFSCPGAD	KGPASDDPRS	KHKFKIHTYS	SPTFCDHCGS
130	140	150	160	170	180
LLYGLIHQGM	KCDTCMMNVH	KRCVMNVPSL	CGTDHTERRG	RIYIQAHIDR	DVLIVLVRDA
190	200	210	220	230	240
KNLVPMDPNG	LSDPYVKLKL	IPDPKSESKQ	KTKTIKCSLN	PEWNETFRFQ	LKESDKDRRL
250	260	270	280	290	300
SVEIWDWDLT	SRNDFMGSLS	FGISELQKAS	VDGWFKLLSQ	EEGEYFNVPV	PPEGSEANEE
310	320	330	340	350	360
LRQKFERAKI	SQGTKVPEEK	TTNTVSKFDN	NGNRDRMKLT	DFNFLMVLGK	GSFGKVMLSE
370	380	390	400	410	420
RKGTDELYAV	KILKKDVVIQ	DDDVECTMVE	KRVLALPGKP	PFLTQLHSCF	QTMDRLYFVM
430	440	450	460	470	480
EYVNGGDLMY	HIQQVGRFKE	PHAVFYAAEI	AIGLFFLQSK	GIIYRDLKLD	NVMLDSEGHI
490	500	510	520	530	540
KIADFGMCKE	NIWDGVTTKT	FCGTPDYIAP	EIIAYQPYGK	SVDWWAFGVL	LYEMLAGQAP
550	560	570	580	590	600
FEGEDEDELF	QSIMEHNVAY	PKSMSKEAVA	ICKGLMTKHP	GKRLGCGPEG	ERDIKEHAFF
610	620	630	640	650	660
RYIDWEKLER	KEIQPPYKPK	ARDKRDTSNF	DKEFTRQPVE	LTPTDKLFIM	NLDQNEFAGF
670
SYTNPEFVIN	V