P05126

SS
Gene name
PRKCB (PRKCB1)
Protein name
Protein kinase C beta type
Names
PKC-B , PKC-beta , EC 2.7.11.13
Species
Bos taurus (Bovine)
KEGG Pathway
bta:282325
EC number
2.7.11.-: Protein-serine/threonine kinases
Protein Class

Descriptions

PRKCA encodes for Protein kinase C (PKC) alpha type belonging to the PCKs family and is involved in various cellular processes, including cell growth, immune response, muscle contraction, and synaptic plasticity. A well-known autoinhibitory region of the PKC family is a pseudosubstrate sequence at residues 1-30 that directly interacts with and blocks the catalytic activity of the kinase domain. Subsequences of the pseudosubstrate region are the C1 domains (C1A and C1B that bind diacylglycerol (DAG)), and the C2 domain (which binds to anionic phospholipids in a Ca2+-dependent manner). The C1A (residues 31-100) domain coordinates a network of domain-domain intramolecular interactions, including direct C1A-C2 contacts. The pseudosubstrate and C1A domains function as a single functional unit and are required to maintain autoinhibition. Additionally, the absence of the C1A domain significantly increases basal activity.

Autoinhibitory domains (AIDs)

101-151 (C1B domain) SS

Target domain

344-586 (Protein kinase domain)

Relief mechanism

Ligand binding

Assay

152-177 (C1B-C2 linker) SS

Target domain

344-586 (Protein kinase domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P05126

Entry ID Method Resolution Chain Position Source
AF-P05126-F1 Predicted AlphaFoldDB

83 variants for P05126

Variant ID(s) Position Change Description Diseaes Association Provenance
rs471430714 21 A>V No EVA
rs439994079 24 G>D No EVA
rs442663793 28 Q>E No EVA
rs462614185 34 V>G No EVA
rs136110618 39 F>S No EVA
rs133778059 40 T>P No EVA
rs445343340 43 F>L No EVA
rs135060422 48 T>P No EVA
rs459056866 49 F>L No EVA
rs447666397 55 D>A No EVA
rs479121365 55 D>N No EVA
rs455924986 76 K>M No EVA
rs469524089 77 R>G No EVA
rs436911272 78 C>G No EVA
rs470447684 81 F>L No EVA
rs439158255 83 T>P No EVA
rs452741022 84 F>S No EVA
rs452741022 84 F>Y No EVA
rs441859850 86 C>F No EVA
rs473118699 86 C>G No EVA
rs482052797 90 D>N No EVA
rs444561787 94 A>P No EVA
rs458222966 95 S>P No EVA
rs452413798 135 C>* No EVA
rs432266321 135 C>F No EVA
rs476493980 135 C>R No EVA
rs471984452 137 M>I No EVA
rs440788541 138 N>K No EVA
rs460845928 139 V>D No EVA
rs474517580 140 H>L No EVA
rs474517580 140 H>P No EVA
rs443771168 140 H>Q No EVA
rs463918365 141 K>E No EVA
rs477678847 141 K>R No EVA
rs446287553 142 R>L No EVA
rs479777840 143 C>R No EVA
rs448505417 143 C>S No EVA
rs437294173 144 V>G No EVA
rs468625717 144 V>L No EVA
rs432185196 145 M>K No EVA
rs469953642 145 M>L No EVA
rs452284658 146 N>K No EVA
rs465918275 147 V>D No EVA
rs465918275 147 V>G No EVA
rs454380199 149 S>R No EVA
rs474454307 151 C>W No EVA
rs457055364 153 T>K No EVA
rs443286513 153 T>P No EVA
rs471150419 154 D>A No EVA
rs459997990 155 H>L No EVA
rs439801668 155 H>N No EVA
rs480117371 156 T>A No EVA
rs462133107 157 E>G No EVA
rs450875469 163 Y>* No EVA
rs464688963 166 A>P No EVA
rs477210094 168 I>V No EVA
rs445832597 169 E>G No EVA
rs465853156 171 E>* No EVA
rs434645009 172 V>A No EVA
rs434645009 172 V>D No EVA
rs434645009 172 V>G No EVA
rs454717342 173 L>R No EVA
rs440804872 191 L>F No EVA
rs463287085 192 S>L No EVA
rs477052343 195 Y>F No EVA
rs445718844 198 L>M No EVA
rs459441724 200 L>M No EVA
rs479556941 202 P>S No EVA
rs448693940 205 K>Q No EVA
rs468836856 206 S>R No EVA
rs437463376 207 E>G No EVA
rs451205515 208 S>R No EVA
rs464491266 212 T>N No EVA
rs452895924 296 E>D No EVA
rs462198009 390 E>A No EVA
rs482404053 398 G>A No EVA
rs449766592 409 C>S No EVA
rs443015899 467 L>M No EVA
rs448848364 511 E>D No EVA
rs475436101 522 V>E No EVA
rs439675273 572 C>* No EVA
rs471691623 641 L>R No EVA
rs444769899 653 D>E No EVA

No associated diseases with P05126

12 regional properties for P05126

Type Name Position InterPro Accession
domain C2 domain 158 - 277 IPR000008
domain Protein kinase domain 342 - 600 IPR000719
domain AGC-kinase, C-terminal 601 - 671 IPR000961
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 36 - 87 IPR002219-1
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 101 - 153 IPR002219-2
active_site Serine/threonine-protein kinase, active site 462 - 474 IPR008271
binding_site Protein kinase, ATP binding site 348 - 371 IPR017441
domain Protein kinase, C-terminal 623 - 662 IPR017892
domain Diacylglycerol/phorbol-ester binding 34 - 48 IPR020454-1
domain Diacylglycerol/phorbol-ester binding 50 - 59 IPR020454-2
domain Diacylglycerol/phorbol-ester binding 63 - 74 IPR020454-3
domain Diacylglycerol/phorbol-ester binding 140 - 152 IPR020454-4

Functions

Description
EC Number 2.7.11.- Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

10 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
diacylglycerol-dependent serine/threonine kinase activity Catalysis of the reaction
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
histone H3T6 kinase activity Catalysis of the reaction
nuclear androgen receptor binding Binding to a nuclear androgen receptor.
nuclear receptor coactivator activity A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions
zinc ion binding Binding to a zinc ion (Zn).

15 GO annotations of biological process

Name Definition
adaptive immune response An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
B cell activation The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
B cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of glucose transmembrane transport Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of insulin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of angiogenesis Any process that activates or increases angiogenesis.
positive regulation of B cell receptor signaling pathway Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
positive regulation of canonical NF-kappaB signal transduction Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of vascular endothelial growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
post-translational protein modification The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
regulation of glucose transmembrane transport Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

24 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P24583 PKC1 Protein kinase C-like 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P04409 PRKCA Protein kinase C alpha type Bos taurus (Bovine) EV SS
P05128 PRKCG Protein kinase C gamma type Bos taurus (Bovine) SS
A1A4I4 PKN1 Serine/threonine-protein kinase N1 Bos taurus (Bovine) SS
A2VDV2 STK38 Serine/threonine-protein kinase 38 Bos taurus (Bovine) SS
P13677 inaC Protein kinase C, eye isozyme Drosophila melanogaster (Fruit fly) SS
P05130 Pkc53E Protein kinase C, brain isozyme Drosophila melanogaster (Fruit fly) SS
P05129 PRKCG Protein kinase C gamma type Homo sapiens (Human) SS
P17252 PRKCA Protein kinase C alpha type Homo sapiens (Human) EV
P05771 PRKCB Protein kinase C beta type Homo sapiens (Human) SS
Q02156 PRKCE Protein kinase C epsilon type Homo sapiens (Human) SS
P24723 PRKCH Protein kinase C eta type Homo sapiens (Human) SS
P20444 Prkca Protein kinase C alpha type Mus musculus (Mouse) SS
P63318 Prkcg Protein kinase C gamma type Mus musculus (Mouse) SS
P68404 Prkcb Protein kinase C beta type Mus musculus (Mouse) SS
P16054 Prkce Protein kinase C epsilon type Mus musculus (Mouse) PR
P23298 Prkch Protein kinase C eta type Mus musculus (Mouse) PR
P05696 Prkca Protein kinase C alpha type Rattus norvegicus (Rat) SS
P63319 Prkcg Protein kinase C gamma type Rattus norvegicus (Rat) SS
Q64617 Prkch Protein kinase C eta type Rattus norvegicus (Rat) PR
P68403 Prkcb Protein kinase C beta type Rattus norvegicus (Rat) SS
P90980 pkc-2 Protein kinase C-like 2 Caenorhabditis elegans SS
A8KBH6 prkcb Protein kinase C beta type Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q7SY24 prkcbb Protein kinase C beta type Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MADPAAGPPP SEGEESTVRF ARKGALRQKN VHEVKNHKFT ARFFKQPTFC SHCTDFIWGF
70 80 90 100 110 120
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPASDDPRS KHKFKIHTYS SPTFCDHCGS
130 140 150 160 170 180
LLYGLIHQGM KCDTCMMNVH KRCVMNVPSL CGTDHTERRG RIYIQAHIER EVLIVVVRDA
190 200 210 220 230 240
KNLVPMDPNG LSDPYVKLKL IPDPKSESKQ KTKTIKCSLN PEWNETFRFQ LKESDKDRRL
250 260 270 280 290 300
SVEIWDWDLT SRNDFMGSLS FGISELQKAG VDGWFKLLSQ EEGEYFNVPV PPEGSEGNEE
310 320 330 340 350 360
LRQKFERAKI GPGPKTPEEK TTNTISKFDN NGNRDRMKLT DFNFLMVLGK GSFGKVMLSE
370 380 390 400 410 420
RKGTDELYAV KILKKDVVIQ DDDVECTMVE KRVLALPGKP PFLTQLHSCF QTMDRLYFVM
430 440 450 460 470 480
EYVNGGDLMY HIQQVGRFKE PHAVFYAAEI AIGLFFLQSK GIIYRDLKLD NVMLDSEGHI
490 500 510 520 530 540
KIADFGMCKE NIWDGVTTKT FCGTPDYIAP EIIAYQPYGK SVDWWAFGVL LYEMLAGQAP
550 560 570 580 590 600
FEGEDEDELF QSIMEHNVAY PKSMSKEAVA ICKGLMTKHP GKRLGCGPEG ERDIKEHAFF
610 620 630 640 650 660
RYIDWEKLER KEIQPPYKPK ARDKRDTSNF DKEFTRQPVE LTPTDKLFIM NLDQNEFAGF
670
SYTNPEFVIN V