P04896

PR
Gene name
GNAS (GNAS1)
Protein name
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Names
Adenylate cyclase-stimulating G alpha protein
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281793
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-150 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

43 structures for P04896

Entry ID Method Resolution Chain Position Source
1AZS X-ray 230 A C 1-394 PDB
1AZT X-ray 230 A A/B 1-394 PDB
1CJK X-ray 300 A C 1-394 PDB
1CJT X-ray 280 A C 1-394 PDB
1CJU X-ray 280 A C 1-394 PDB
1CJV X-ray 300 A C 1-394 PDB
1CS4 X-ray 250 A C 1-394 PDB
1CUL X-ray 240 A C 1-394 PDB
1TL7 X-ray 280 A C 1-394 PDB
1U0H X-ray 290 A C 1-394 PDB
2GVD X-ray 290 A C 1-394 PDB
2GVZ X-ray 327 A C 1-394 PDB
3C14 X-ray 268 A C 1-394 PDB
3C15 X-ray 278 A C 1-394 PDB
3C16 X-ray 287 A C 1-394 PDB
3G82 X-ray 311 A C 1-394 PDB
3MAA X-ray 300 A C 1-394 PDB
3SN6 X-ray 320 A A 1-394 PDB
6NBF EM 300 A PDB
6NBH EM 350 A PDB
6NBI EM 400 A PDB
6R3Q EM 340 A B 1-394 PDB
6R4O EM 420 A B 1-394 PDB
6R4P EM 310 A B 1-394 PDB
7D68 EM 300 A PDB
7DTY EM 298 A A 1-394 PDB
7EQ1 EM 330 A PDB
7FIM EM 340 A A 1-394 PDB
7FIN EM 310 A A 1-394 PDB
7FIY EM 340 A A 1-394 PDB
7JJO EM 260 A A 1-394 PDB
7PDE EM 450 A B 1-394 PDB
7PDF EM 380 A B 1-394 PDB
7S0G EM 386 A A 384-394 PDB
7VQX EM 274 A A 1-394 PDB
7WBJ EM 342 A A 1-394 PDB
8BUZ EM 350 A B 1-394 PDB
8BV5 EM 354 A B 1-394 PDB
8DCR EM 260 A A 1-394 PDB
8DCS EM 250 A A 1-394 PDB
8ITL EM 323 A A 1-394 PDB
8ITM EM 313 A A 1-394 PDB
AF-P04896-F1 Predicted AlphaFoldDB

48 variants for P04896

Variant ID(s) Position Change Description Diseaes Association Provenance
rs457063131 55 T>I No EVA
rs435261957 60 M>I No EVA
rs470531739 68 F>L No EVA
rs452801441 71 E>V No EVA
rs447406450 76 D>G No EVA
rs477047276 85 D>N No EVA
rs482345368 105 T>P No EVA
rs469162113 144 P>H No EVA
rs472786815 146 F>C No EVA
rs443085661 146 F>I No EVA
rs472786815 146 F>S No EVA
rs466503374 221 M>I No EVA
rs433610251 221 M>R No EVA
rs433610251 221 M>T No EVA
rs455419465 221 M>V No EVA
rs445558785 222 F>Y No EVA
rs478513568 223 D>G No EVA
rs469621564 224 V>E No EVA
rs450944270 226 G>V No EVA
rs480528916 227 Q>E No EVA
rs462121041 229 D>N No EVA
rs440444600 230 E>D No EVA
rs479653384 233 K>Q No EVA
rs458035050 238 F>L No EVA
rs438708256 239 N>S No EVA
rs110996434 261 N>H No EVA
rs109049760 261 N>T No EVA
rs473990741 267 Q>L No EVA
rs455454369 270 L>P No EVA
rs474104728 272 L>R No EVA
rs439547580 284 T>P No EVA
rs482262566 289 L>V No EVA
rs463606441 290 F>V No EVA
rs462857894 291 L>F No EVA
rs461904231 295 D>E No EVA
rs474025418 295 D>V No EVA
rs440153407 307 K>* No EVA
rs473026823 309 E>A No EVA
rs451291357 314 E>K No EVA
rs432816092 315 F>I No EVA
rs457512975 321 P>H No EVA
rs434887362 322 E>D No EVA
rs468630669 322 E>K No EVA
rs446957592 322 E>V No EVA
rs436731237 359 C>F No EVA
rs436731237 359 C>Y No EVA
rs463194544 381 D>E No EVA
rs437363707 384 Q>H No EVA

No associated diseases with P04896

No regional properties for P04896

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P04896

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
heterotrimeric G-protein complex Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
intrinsic component of membrane The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane.
trans-Golgi network membrane The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

12 GO annotations of molecular function

Name Definition
adenylate cyclase activator activity Increases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
beta-2 adrenergic receptor binding Binding to a beta-2 adrenergic receptor.
corticotropin-releasing hormone receptor 1 binding Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.
D1 dopamine receptor binding Binding to a D1 dopamine receptor.
G protein-coupled receptor binding Binding to a G protein-coupled receptor.
G-protein beta/gamma-subunit complex binding Binding to a complex of G-protein beta/gamma subunits.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
insulin-like growth factor receptor binding Binding to an insulin-like growth factor receptor.
ionotropic glutamate receptor binding Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
metal ion binding Binding to a metal ion.
mu-type opioid receptor binding Binding to a mu-type opioid receptor.

12 GO annotations of biological process

Name Definition
adenylate cyclase-activating adrenergic receptor signaling pathway An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process.
adenylate cyclase-activating dopamine receptor signaling pathway An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process.
adenylate cyclase-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
adenylate cyclase-modulating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
bone development The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
cognition The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
developmental growth The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
hair follicle placode formation The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.
platelet aggregation The adhesion of one platelet to one or more other platelets via adhesion molecules.
positive regulation of cAMP-mediated signaling Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
sensory perception of chemical stimulus The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38408 GNA14 Guanine nucleotide-binding protein subunit alpha-14 Bos taurus (Bovine) PR
P0C7Q4 GNAT3 Guanine nucleotide-binding protein G Bos taurus (Bovine) SS
P04696 GNAT2 Guanine nucleotide-binding protein G Bos taurus (Bovine) SS
P04695 GNAT1 Guanine nucleotide-binding protein G Bos taurus (Bovine) SS
P63097 GNAI1 Guanine nucleotide-binding protein G Bos taurus (Bovine) SS
P08239 GNAO1 Guanine nucleotide-binding protein G Bos taurus (Bovine) SS
P63091 GNAS Guanine nucleotide-binding protein G(s) subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) PR
P38405 GNAL Guanine nucleotide-binding protein G Homo sapiens (Human) SS
P29797 GNAS Guanine nucleotide-binding protein G(s) subunit alpha Sus scrofa (Pig) PR
P93564 GPA1 Guanine nucleotide-binding protein alpha-1 subunit Solanum tuberosum (Potato) SS
P38406 Gnal Guanine nucleotide-binding protein G Rattus norvegicus (Rat) SS
Q63803 Gnas Guanine nucleotide-binding protein G Rattus norvegicus (Rat) SS
Q0DJ33 GPA1 Guanine nucleotide-binding protein alpha-1 subunit Oryza sativa subsp. japonica (Rice) SS
P49084 GPA1 Guanine nucleotide-binding protein alpha-1 subunit Glycine max (Soybean) (Glycine hispida) SS
P93163 GPA2 Guanine nucleotide-binding protein alpha-2 subunit Glycine max (Soybean) (Glycine hispida) SS
O80462 XLG1 Extra-large guanine nucleotide-binding protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
P18064 GPA1 Guanine nucleotide-binding protein alpha-1 subunit Arabidopsis thaliana (Mouse-ear cress) SS
P26981 GPA1 Guanine nucleotide-binding protein alpha-1 subunit Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
10 20 30 40 50 60
MGCLGNSKTE DQRNEEKAQR EANKKIEKQL QKDKQVYRAT HRLLLLGAGE SGKSTIVKQM
70 80 90 100 110 120
RILHVNGFNG EGGEEDPQAA RSNSDGEKAT KVQDIKNNLK EAIETIVAAM SNLVPPVELA
130 140 150 160 170 180
NPENQFRVDY ILSVMNVPDF DFPPEFYEHA KALWEDEGVR ACYERSNEYQ LIDCAQYFLD
190 200 210 220 230 240
KIDVIKQDDY VPSDQDLLRC RVLTSGIFET KFQVDKVNFH MFDVGGQRDE RRKWIQCFND
250 260 270 280 290 300
VTAIIFVVAS SSYNMVIRED NQTNRLQEAL NLFKSIWNNR WLRTISVILF LNKQDLLAEK
310 320 330 340 350 360
VLAGKSKIED YFPEFARYTT PEDATPEPGE DPRVTRAKYF IRDEFLRIST ASGDGRHYCY
370 380 390
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