P02299
Gene name |
His3 |
Protein name |
Histone H3 |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG33866 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
19 structures for P02299
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1KNA | X-ray | 210 A | P | 2-17 | PDB |
| 1KNE | X-ray | 240 A | P | 2-17 | PDB |
| 2NQB | X-ray | 230 A | A/E | 2-136 | PDB |
| 2PYO | X-ray | 243 A | A/E | 2-136 | PDB |
| 2YBA | X-ray | 255 A | C/D | 2-20 | PDB |
| 4QLC | X-ray | 350 A | A/E | 2-136 | PDB |
| 4QUF | X-ray | 250 A | P/Q/R/T/U/V | 2-16 | PDB |
| 4U68 | X-ray | 180 A | D/E/F | 5-15 | PDB |
| 4UUZ | X-ray | 290 A | A | 1-136 | PDB |
| 4X23 | X-ray | 350 A | A/E/K/O | 41-133 | PDB |
| 5WCU | X-ray | 553 A | A/E/K/O | 39-136 | PDB |
| 6ASZ | X-ray | 152 A | P | 6-11 | PDB |
| 6AT0 | X-ray | 128 A | P | 6-11 | PDB |
| 6DZT | EM | 299 A | A/E | 1-136 | PDB |
| 6MHA | X-ray | 150 A | B | 6-11 | PDB |
| 6PWE | EM | 395 A | A/E | 1-136 | PDB |
| 6PWF | EM | 407 A | A/E | 1-136 | PDB |
| 7VRF | X-ray | 170 A | C/D | 5-15 | PDB |
| AF-P02299-F1 | Predicted | AlphaFoldDB |
No variants for P02299
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P02299 | |||||
No associated diseases with P02299
1 regional properties for P02299
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Histone H2A/H2B/H3 | 1 - 132 | IPR007125 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nucleosome | A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| polytene chromosome | A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible. |
| RCAF complex | A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| nucleosomal DNA binding | Binding to the DNA portion of a nucleosome. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| structural constituent of chromatin | The action of a molecule that contributes to the structural integrity of chromatin. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
36 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P68428 | Histone H3.2 | Triticum aestivum (Wheat) | PR | |
| Q5E9F8 | H3-3B | Histone H3.3 | Bos taurus (Bovine) | PR |
| P68432 | Histone H3.1 | Bos taurus (Bovine) | PR | |
| P84227 | Histone H3.2 | Bos taurus (Bovine) | PR | |
| P84247 | H3-X | Histone H3.3 | Gallus gallus (Chicken) | PR |
| P84229 | H3-VIII | Histone H3.2 | Gallus gallus (Chicken) | PR |
| P02299 | His3 | Histone H3 | Drosophila melanogaster (Fruit fly) | PR |
| Q71H73 | Histone H3.3 | Vitis vinifera (Grape) | PR | |
| P84243 | H3-3B | Histone H3.3 | Homo sapiens (Human) | PR |
| P68431 | H3C12 | Histone H3.1 | Homo sapiens (Human) | PR |
| Q16695 | H3-4 | Histone H3.1t | Homo sapiens (Human) | PR |
| Q71DI3 | H3C13 | Histone H3.2 | Homo sapiens (Human) | PR |
| P69246 | H3C4 | Histone H3.2 | Zea mays (Maize) | PR |
| P68433 | H3c11 | Histone H3.1 | Mus musculus (Mouse) | PR |
| P84244 | H3-3b | Histone H3.3 | Mus musculus (Mouse) | PR |
| P84228 | H3c15 | Histone H3.2 | Mus musculus (Mouse) | PR |
| Q71LE2 | H3-3A | Histone H3.3 | Sus scrofa (Pig) | PR |
| P84245 | H3-3b | Histone H3.3 | Rattus norvegicus (Rat) | PR |
| O35799 | Hfe | Hereditary hemochromatosis protein homolog | Rattus norvegicus (Rat) | PR |
| Q6LED0 | Histone H3.1 | Rattus norvegicus (Rat) | PR | |
| Q0JCT1 | H3 | Histone H3.3 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAD9 | H3R-21 | Histone H3.2 | Oryza sativa subsp japonica (Rice) | PR |
| Q27490 | his-70 | Histone H3.3-like type 1 | Caenorhabditis elegans | PR |
| Q10453 | his-71 | Histone H3.3 type 1 | Caenorhabditis elegans | PR |
| Q27532 | his-74 | Histone H3.3-like type 2 | Caenorhabditis elegans | PR |
| P08898 | his-2 | Histone H3 | Caenorhabditis elegans | PR |
| Q9FX60 | At1g13370 | Histone H3-like 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXI7 | MGH3 | Histone H3-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKQ3 | At5g65350 | Histone H3-like 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P59226 | HTR2 | Histone H3.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LR02 | At1g75600 | Histone H3-like 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P59169 | HTR4 | Histone H3.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6P823 | TGas113e22.1 | Histone H3.3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q28D37 | TGas081o10.1 | Histone H3.2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6PI20 | h3f3a | Histone H3.3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q4QRF4 | zgc:113984; | Histone H3.2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARTKQTARK | STGGKAPRKQ | LATKAARKSA | PATGGVKKPH | RYRPGTVALR | EIRRYQKSTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLIRKLPFQR | LVREIAQDFK | TDLRFQSSAV | MALQEASEAY | LVGLFEDTNL | CAIHAKRVTI |
| 130 | |||||
| MPKDIQLARR | IRGERA |