P00524

SS
Gene name
V-SRC
Protein name
Tyrosine-protein kinase transforming protein Src
Names
pp60v-src, p60-Src, v-Src
Species
Avian leukosis virus RSA (RSV-SRA) (Rous sarcoma virus (strainSchmidt-Ruppin A))
KEGG Pathway
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

SRC is a non-receptor protein tyrosine kinase involved in a variety of signal transduction pathways. The C-terminal autoinhibitory region interacts with the SH2 domain to inhibit the kinase domain.

Autoinhibitory domains (AIDs)

81-142 (SH3 domain) SS

Target domain

267-517 (Protein kinase domain)

Relief mechanism

Ligand binding

Assay

246-266 (SH2-CD linker) SS

Target domain

267-517 (Protein kinase domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

11 structures for P00524

Entry ID Method Resolution Chain Position Source
1BKL X-ray 210 A A 145-249 PDB
1BKM X-ray 200 A A 145-249 PDB
1IS0 X-ray 190 A A/B 144-249 PDB
1KC2 X-ray 210 A A 145-247 PDB
1NZL X-ray 190 A A/B 145-247 PDB
1NZV X-ray 210 A A/B 145-247 PDB
1SHA X-ray 150 A A 144-247 PDB
1SHB X-ray 200 A A 144-247 PDB
1SKJ X-ray 200 A A 145-249 PDB
1SPR X-ray 250 A A/B/C/D 144-247 PDB
1SPS X-ray 270 A A/B/C 144-247 PDB

No variants for P00524

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P00524

No associated diseases with P00524

7 regional properties for P00524

Type Name Position InterPro Accession
domain Protein kinase domain 267 - 517 IPR000719
domain SH2 domain 146 - 245 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 268 - 516 IPR001245
domain SH3 domain 81 - 142 IPR001452
active_site Tyrosine-protein kinase, active site 382 - 394 IPR008266
binding_site Protein kinase, ATP binding site 273 - 295 IPR017441
domain Tyrosine-protein kinase, catalytic domain 267 - 516 IPR020635

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGSSKSKPKD PSQRRCSLEP PDSTHHGGFP ASQTPNKTAA PDTHRTPSRS FGTVATEPKL
70 80 90 100 110 120
FGGFNTSDTV TSPQRAGALA GGVTTFVALY DYESRTETDL SFKKGERLQI VNNTEGDWWL
130 140 150 160 170 180
AHSLTTGQTG YIPSNYVAPS DSIQAEEWYF GKITRRESER LLLNPENPRG TFLVRESETT
190 200 210 220 230 240
KGAYCLSVSD FDNAKGLNVK HYKIRKLDSG GFYITSRTQF SSLQQLVAYY SKHADGLCHR
250 260 270 280 290 300
LTNVCPTSKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT RVAIKTLKPG
310 320 330 340 350 360
TMSPEAFLQE AQVMKKLRHE KLVQLYAVVS EEPIYIVTEY MSKGSLLDFL KGEMGKYLRL
370 380 390 400 410 420
PQLVDMAAQI ASGMAYVERM NYVHRDLRAA NILVGENLVC KVADFGLARL IEDNEYTARQ
430 440 450 460 470 480
GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LLTELTTKGR VPYPGMGNGE VLDRVERGYR
490 500 510 520
MPCPPECPES LHDLMCQCWR RDPEERPTFE YLQAQLLPAC VLEVAE