P00523

EV
Gene name
SRC
Protein name
Proto-oncogene tyrosine-protein kinase Src
Names
Proto-oncogene c-Src, pp60c-src, p60-Src
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396442
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class
TYROSINE-PROTEIN KINASE (PTHR24418)

Descriptions

Src is a non-receptor protein tyrosine kinase involved in a variety of signal transduction pathways. SH3 and SH2 domains are assembled on the backside of the kinases and SH2 domain binds to phosphorylated Y527 in C-terminal regulatory tail and the SH3 domain binds to the linker (proline-motif) connecting the SH2 and kinase domains. The binding of pY527 to SH2 domain clamps the SH3-SH2 tandem in the autoinhibitory conformation. Disruption of either SH2-pY527 or SH3-linker interaction disassembles the autoinhibitory conformations and eventually leads to the activation of Src kinases.

Autoinhibitory domains (AIDs)

81-142 (SH3 domain) EV

Target domain

267-520 (Protein kinase domain)

Relief mechanism

Ligand binding

Assay

Structural analysis

146-245 (SH2 domain) EV

Target domain

267-520 (Protein kinase domain)

Relief mechanism

Ligand binding, Partner binding

Assay

Structural analysis

246-266 (Linker between SH2-kinase domain) EV

Target domain

267-520 (Protein kinase domain)

Relief mechanism

Assay

Structural analysis

521-533 (C-terminal regulatory tail) EV

Target domain

267-520 (Protein kinase domain)

Relief mechanism

PTM

Assay

Structural analysis

Accessory elements

403-427 (Activation loop from InterPro)

Target domain

267-520 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

138 structures for P00523

Entry ID Method Resolution Chain Position Source
1F1W X-ray 210 A A 145-247 PDB
1F2F X-ray 170 A A 145-247 PDB
1NLO NMR - C 81-140 PDB
1NLP NMR - C 81-140 PDB
1P13 X-ray 163 A A/B 145-246 PDB
1PRL NMR - C 77-140 PDB
1PRM NMR - C 77-140 PDB
1RLP NMR - C 77-140 PDB
1RLQ NMR - C 77-140 PDB
1SRL NMR - A 77-140 PDB
1SRM NMR - A 77-140 PDB
2HWO X-ray 250 A A/B 251-533 PDB
2HWP X-ray 248 A A/B 251-533 PDB
2OIQ X-ray 207 A A/B 251-533 PDB
2PTK X-ray 235 A A 81-533 PDB
2QI8 X-ray 232 A A/B 251-533 PDB
2QLQ X-ray 233 A A/B 251-533 PDB
2QQ7 X-ray 238 A A/B 251-533 PDB
3D7T X-ray 290 A B 251-533 PDB
3D7U X-ray 411 A B/D 260-523 PDB
3DQW X-ray 202 A A/B/C/D 251-533 PDB
3DQX X-ray 230 A A/B 251-533 PDB
3EL7 X-ray 280 A A 251-533 PDB
3EL8 X-ray 230 A A/B 251-533 PDB
3EN4 X-ray 255 A A/B 251-533 PDB
3EN5 X-ray 266 A A/B 251-533 PDB
3EN6 X-ray 239 A A/B 251-533 PDB
3EN7 X-ray 281 A A/B 251-533 PDB
3F3T X-ray 250 A A/B 251-533 PDB
3F3U X-ray 250 A A/B 251-533 PDB
3F3V X-ray 260 A A/B 251-533 PDB
3F3W X-ray 260 A A/B 251-533 PDB
3F6X X-ray 235 A A/B/C/D 251-533 PDB
3FJ5 X-ray 165 A A/B 85-140 PDB
3G5D X-ray 220 A A/B 251-533 PDB
3G6G X-ray 231 A A/B 251-533 PDB
3G6H X-ray 235 A A/B 251-533 PDB
3GEQ X-ray 220 A A/B 251-533 PDB
3LOK X-ray 248 A A/B 251-533 PDB
3OEZ X-ray 240 A A/B 251-533 PDB
3OF0 X-ray 270 A A/B 251-533 PDB
3QLF X-ray 275 A A/B 251-533 PDB
3QLG X-ray 275 A A/B 251-533 PDB
3SVV X-ray 220 A A/B 251-533 PDB
3TZ7 X-ray 330 A A/B 251-533 PDB
3TZ8 X-ray 270 A A/B 251-533 PDB
3TZ9 X-ray 310 A A/B 251-533 PDB
3U4W X-ray 190 A A 259-533 PDB
3U51 X-ray 224 A A/B 259-533 PDB
3UQF X-ray 227 A A/B 251-533 PDB
3UQG X-ray 220 A A/B 251-533 PDB
4AGW X-ray 260 A A/B 251-533 PDB
4DGG X-ray 265 A A/B 251-533 PDB
4FIC X-ray 250 A A/B 251-533 PDB
4HVU X-ray 098 A A 85-141 PDB
4HVV X-ray 110 A A 85-140 PDB
4HVW X-ray 098 A A 85-141 PDB
4JZ3 X-ray 185 A A 85-141 PDB
4JZ4 X-ray 156 A A/B 85-141 PDB
4LE9 X-ray 134 A A 85-141 PDB
4LGG X-ray 241 A A/B 264-533 PDB
4LGH X-ray 284 A A/B 257-533 PDB
4MCV X-ray 273 A A/B 256-533 PDB
4O2P X-ray 210 A A/B 251-533 PDB
4OML X-ray 160 A A 85-141 PDB
4OMM X-ray 190 A A 85-140 PDB
4OMN X-ray 150 A A 85-140 PDB
4OMO X-ray 104 A A/B 85-141 PDB
4OMP X-ray 200 A A 85-139 PDB
4OMQ X-ray 200 A A 85-140 PDB
4QT7 X-ray 155 A A 85-141 PDB
4RTU X-ray 245 A A 85-141 PDB
4RTV X-ray 137 A A 85-141 PDB
4RTW X-ray 124 A A/C 85-141 PDB
4RTX X-ray 132 A A/B/C/D 85-141 PDB
4RTY X-ray 128 A A 85-141 PDB
4RTZ X-ray 098 A A 85-141 PDB
4U5J X-ray 226 A A/B 251-533 PDB
4YBJ X-ray 261 A A/B 251-533 PDB
4YBK X-ray 250 A A 251-533 PDB
5BMM X-ray 250 A A/B 251-533 PDB
5D10 X-ray 270 A A/B 251-533 PDB
5D11 X-ray 230 A A/B 251-533 PDB
5D12 X-ray 300 A A/B 251-533 PDB
5EC7 X-ray 165 A A/B/C 85-140 PDB
5ECA X-ray 116 A A 85-141 PDB
5I11 X-ray 195 A A 85-141 PDB
5J5S X-ray 215 A A/B 251-533 PDB
5K9I X-ray 250 A A/B 251-533 PDB
5OAV X-ray 095 A A/C 85-141 PDB
5OB0 X-ray 117 A A 85-141 PDB
5OB1 X-ray 117 A A 85-141 PDB
5OB2 X-ray 180 A A/C 85-141 PDB
5SWH X-ray 250 A A/B 252-533 PDB
5SYS X-ray 280 A A/B 251-533 PDB
5T0P X-ray 250 A A/B 251-533 PDB
5TEH X-ray 299 A A/B 251-533 PDB
5XP5 X-ray 210 A A/B 251-533 PDB
5XP7 X-ray 201 A A/B 251-533 PDB
6HVE X-ray 190 A A/B 251-533 PDB
6HVF X-ray 210 A A/B 251-533 PDB
6L8L X-ray 289 A A/B/C/D 251-533 PDB
6WIW X-ray 230 A A/B 251-533 PDB
6XVM X-ray 090 A A/B/C/D 82-141 PDB
6XVN X-ray 170 A A/B 82-141 PDB
6XVO X-ray 170 A A 82-141 PDB
6XX2 X-ray 125 A A 85-141 PDB
6XX3 X-ray 136 A A 85-141 PDB
6XX4 X-ray 105 A A 85-141 PDB
6XX5 X-ray 130 A A 85-141 PDB
7A30 X-ray 167 A A 82-141 PDB
7A31 X-ray 094 A A/B 82-141 PDB
7A32 X-ray 115 A A/B/C/D 82-141 PDB
7A33 X-ray 096 A A/B 82-141 PDB
7A34 X-ray 185 A A 82-141 PDB
7A35 X-ray 131 A A/B 82-141 PDB
7A36 X-ray 150 A A/B 82-141 PDB
7A37 X-ray 152 A A/B 82-141 PDB
7A38 X-ray 162 A A/B 82-141 PDB
7A39 X-ray 165 A A/B 82-141 PDB
7A3A X-ray 180 A A 82-141 PDB
7A3B X-ray 191 A A 82-141 PDB
7A3C X-ray 180 A A/B/C/D 81-141 PDB
7A3D X-ray 220 A A/B 82-141 PDB
7A3E X-ray 152 A A 81-141 PDB
7AH3 X-ray 195 A A/B 251-533 PDB
7D57 X-ray 210 A A/B 251-533 PDB
7D5O X-ray 269 A A/B 251-533 PDB
7NER X-ray 155 A A 81-141 PDB
7NES X-ray 135 A A 81-141 PDB
7NET X-ray 150 A A/B 81-141 PDB
7PVW X-ray 150 A A/B 82-141 PDB
7PVX X-ray 143 A A/C 82-141 PDB
7PVY X-ray 140 A A 81-141 PDB
7PVZ X-ray 200 A A/B 81-141 PDB
7PW0 X-ray 170 A A/B/C/D/E/F/G/H 82-141 PDB
7WF5 X-ray 180 A A/B 251-533 PDB
AF-P00523-F1 Predicted AlphaFoldDB

25 variants for P00523

Variant ID(s) Position Change Description Diseaes Association Provenance
rs737050630 12 S>T No Ensembl
rs733270406 25 H>P No Ensembl
rs733996397 26 H>P No Ensembl
rs737461578 29 F>S No Ensembl
rs732727338 32 S>P No Ensembl
rs741327316 44 H>P No Ensembl
rs732500703 46 T>P No Ensembl
rs740695096 57 E>A No Ensembl
rs731563742 66 T>P No Ensembl
rs1059459076 72 S>P No Ensembl
rs735146349 148 W>G No Ensembl
rs737532680 158 S>P No Ensembl
rs732826274 176 E>G No Ensembl
rs738256696 215 T>P No Ensembl
rs740360366 216 S>P No Ensembl
rs734104709 239 H>P No Ensembl
rs740661507 247 T>P No Ensembl
rs733200424 248 S>P No Ensembl
rs733873798 255 L>P No Ensembl
rs741442204 270 E>G No Ensembl
rs735445953 369 Q>R No Ensembl
rs731409743 394 V>G No Ensembl
rs733677250 498 C>G No Ensembl
rs741234755 501 K>E No Ensembl
rs730986301 521 T>P No Ensembl

No associated diseases with P00523

7 regional properties for P00523

Type Name Position InterPro Accession
domain Protein kinase domain 267 - 520 IPR000719
domain SH2 domain 146 - 245 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 268 - 515 IPR001245
domain SH3 domain 81 - 142 IPR001452
active_site Tyrosine-protein kinase, active site 382 - 394 IPR008266
binding_site Protein kinase, ATP binding site 273 - 295 IPR017441
domain Tyrosine-protein kinase, catalytic domain 267 - 516 IPR020635

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Lipid-anchor
  • Mitochondrion inner membrane
  • Endosome membrane ; Peripheral membrane protein
  • Nucleus
  • Cytoplasm, cytoskeleton
  • Cell junction, focal adhesion
  • Cytoplasm, perinuclear region
  • Localizes to focal adhesion sites following integrin engagement (By similarity)
  • Localization to focal adhesion sites requires myristoylation and the SH3 domain
PANTHER Family PTHR24418 TYROSINE-PROTEIN KINASE
PANTHER Subfamily PTHR24418:SF53 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
PANTHER Protein Class non-receptor tyrosine protein kinase
PANTHER Pathway Category Gonadotropin-releasing hormone receptor pathway
SRC
Angiogenesis
Src
CCKR signaling map
p62 SRC
Integrin signalling pathway
Src
CCKR signaling map
SRC @Galphaq
Cadherin signaling pathway
Src
CCKR signaling map
SRC
CCKR signaling map
p60 SRC
Parkinson disease
Src kinase
CCKR signaling map
p54 SRC

12 GO annotations of cellular component

Name Definition
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome membrane The lipid bilayer surrounding an endosome.
extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

9 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
connexin binding Binding to a connexin, any of a group of related proteins that assemble to form gap junctions.
growth factor receptor binding Binding to a growth factor receptor.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
protein phosphatase binding Binding to a protein phosphatase.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

12 GO annotations of biological process

Name Definition
bone resorption The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
epidermal growth factor receptor signaling pathway The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of extrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
negative regulation of intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
osteoclast development The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
progesterone receptor signaling pathway The series of molecular signals initiated by progesterone binding to its receptor in the cytoplasm.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

81 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A0JNB0 FYN Tyrosine-protein kinase Fyn Bos taurus (Bovine) SS
Q0VBZ0 CSK Tyrosine-protein kinase CSK Bos taurus (Bovine) SS
Q3ZC95 BTK Tyrosine-protein kinase Bos taurus (Bovine) EV SS
Q75R65 JAK2 Tyrosine-protein kinase JAK2 Gallus gallus (Chicken) SS
F1N9Y5 SYK Tyrosine-protein kinase SYK Gallus gallus (Chicken) SS
P09324 YES1 Tyrosine-protein kinase Yes Gallus gallus (Chicken) SS
P41239 CSK Tyrosine-protein kinase CSK Gallus gallus (Chicken) SS
Q02977 YRK Proto-oncogene tyrosine-protein kinase Yrk Gallus gallus (Chicken) SS
Q00944 PTK2 Focal adhesion kinase 1 Gallus gallus (Chicken) EV
P42683 LCK Proto-oncogene tyrosine-protein kinase LCK Gallus gallus (Chicken) SS
Q05876 FYN Tyrosine-protein kinase Fyn Gallus gallus (Chicken) SS
Q8JH64 BTK Tyrosine-protein kinase BTK Gallus gallus (Chicken) SS
Q24592 hop Tyrosine-protein kinase hopscotch Drosophila melanogaster (Fruit fly) PR
P08630 Btk Tyrosine-protein kinase Btk Drosophila melanogaster (Fruit fly) SS
P00528 Src64B Tyrosine-protein kinase Src64B Drosophila melanogaster (Fruit fly) SS
Q9V9J3 Src42A Tyrosine-protein kinase Src42A Drosophila melanogaster (Fruit fly) SS
P41240 CSK Tyrosine-protein kinase CSK Homo sapiens (Human) SS
P51451 BLK Tyrosine-protein kinase Blk Homo sapiens (Human) SS
P06239 LCK Tyrosine-protein kinase Lck Homo sapiens (Human) EV
P23458 JAK1 Tyrosine-protein kinase JAK1 Homo sapiens (Human) SS
P06241 FYN Tyrosine-protein kinase Fyn Homo sapiens (Human) SS
P51813 BMX Cytoplasmic tyrosine-protein kinase BMX Homo sapiens (Human) SS
P09769 FGR Tyrosine-protein kinase Fgr Homo sapiens (Human) SS
P42680 TEC Tyrosine-protein kinase Tec Homo sapiens (Human) SS
O60674 JAK2 Tyrosine-protein kinase JAK2 Homo sapiens (Human) EV
P42679 MATK Megakaryocyte-associated tyrosine-protein kinase Homo sapiens (Human) SS
P52333 JAK3 Tyrosine-protein kinase JAK3 Homo sapiens (Human) SS
Q08881 ITK Tyrosine-protein kinase ITK/TSK Homo sapiens (Human) EV
P07948 LYN Tyrosine-protein kinase Lyn Homo sapiens (Human) SS
P29597 TYK2 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens (Human) EV
Q13882 PTK6 Protein-tyrosine kinase 6 Homo sapiens (Human) EV
P08631 HCK Tyrosine-protein kinase HCK Homo sapiens (Human) EV
P07947 YES1 Tyrosine-protein kinase Yes Homo sapiens (Human) SS
P42685 FRK Tyrosine-protein kinase FRK Homo sapiens (Human) EV
Q06187 BTK Tyrosine-protein kinase BTK Homo sapiens (Human) EV
P12931 SRC Proto-oncogene tyrosine-protein kinase Src Homo sapiens (Human) EV
Q9R117 Tyk2 Non-receptor tyrosine-protein kinase TYK2 Mus musculus (Mouse) SS
P08103 Hck Tyrosine-protein kinase HCK Mus musculus (Mouse) SS
P16277 Blk Tyrosine-protein kinase Blk Mus musculus (Mouse) SS
Q62270 Srms Tyrosine-protein kinase Srms Mus musculus (Mouse) SS
Q64434 Ptk6 Protein-tyrosine kinase 6 Mus musculus (Mouse) SS
P14234 Fgr Tyrosine-protein kinase Fgr Mus musculus (Mouse) SS
P35991 Btk Tyrosine-protein kinase BTK Mus musculus (Mouse) EV
P41241 Csk Tyrosine-protein kinase CSK Mus musculus (Mouse) EV
P25911 Lyn Tyrosine-protein kinase Lyn Mus musculus (Mouse) EV
Q62137 Jak3 Tyrosine-protein kinase JAK3 Mus musculus (Mouse) SS
Q62120 Jak2 Tyrosine-protein kinase JAK2 Mus musculus (Mouse) EV
P06240 Lck Proto-oncogene tyrosine-protein kinase LCK Mus musculus (Mouse) SS
P24604 Tec Tyrosine-protein kinase Tec Mus musculus (Mouse) SS
Q04736 Yes1 Tyrosine-protein kinase Yes Mus musculus (Mouse) SS
P39688 Fyn Tyrosine-protein kinase Fyn Mus musculus (Mouse) SS
P52332 Jak1 Tyrosine-protein kinase JAK1 Mus musculus (Mouse) SS
Q03526 Itk Tyrosine-protein kinase ITK/TSK Mus musculus (Mouse) SS
P41242 Matk Megakaryocyte-associated tyrosine-protein kinase Mus musculus (Mouse) SS
Q922K9 Frk Tyrosine-protein kinase FRK Mus musculus (Mouse) SS
P05480 Src Proto-oncogene tyrosine-protein kinase Src Mus musculus (Mouse) EV
A1Y2K1 FYN Tyrosine-protein kinase Fyn Sus scrofa (Pig) SS
O19064 JAK2 Tyrosine-protein kinase JAK2 Sus scrofa (Pig) SS
Q62662 Frk Tyrosine-protein kinase FRK Rattus norvegicus (Rat) SS
Q62844 Fyn Tyrosine-protein kinase Fyn Rattus norvegicus (Rat) SS
Q07014 Lyn Tyrosine-protein kinase Lyn Rattus norvegicus (Rat) SS
P50545 Hck Tyrosine-protein kinase HCK Rattus norvegicus (Rat) SS
Q01621 Lck Proto-oncogene tyrosine-protein kinase LCK Rattus norvegicus (Rat) SS
Q6P6U0 Fgr Tyrosine-protein kinase Fgr Rattus norvegicus (Rat) SS
Q62689 Jak2 Tyrosine-protein kinase JAK2 Rattus norvegicus (Rat) SS
Q63272 Jak3 Tyrosine-protein kinase JAK3 Rattus norvegicus (Rat) SS
P32577 Csk Tyrosine-protein kinase CSK Rattus norvegicus (Rat) SS
P41243 Matk Megakaryocyte-associated tyrosine-protein kinase Rattus norvegicus (Rat) SS
F1LM93 Yes1 Tyrosine-protein kinase Yes Rattus norvegicus (Rat) SS
Q9WUD9 Src Proto-oncogene tyrosine-protein kinase Src Rattus norvegicus (Rat) SS
G5ECJ6 csk-1 Tyrosine-protein kinase csk-1 Caenorhabditis elegans SS
O45539 src-2 Tyrosine protein-kinase src-2 Caenorhabditis elegans SS
G5EE56 src-1 Tyrosine protein-kinase src-1 Caenorhabditis elegans SS
F4JTP5 STY46 Serine/threonine-protein kinase STY46 Arabidopsis thaliana (Mouse-ear cress) PR
O22558 STY8 Serine/threonine-protein kinase STY8 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWL6 STY17 Serine/threonine-protein kinase STY17 Arabidopsis thaliana (Mouse-ear cress) PR
A1A5H8 yes1 Tyrosine-protein kinase yes Danio rerio (Zebrafish) (Brachydanio rerio) SS
F1RDG9 fynb Tyrosine-protein kinase fynb Danio rerio (Zebrafish) (Brachydanio rerio) SS
O12990 jak1 Tyrosine-protein kinase JAK1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6EWH2 fyna Tyrosine-protein kinase fyna Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q1JPZ3 src Proto-oncogene tyrosine-protein kinase Src Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MGSSKSKPKD PSQRRRSLEP PDSTHHGGFP ASQTPNKTAA PDTHRTPSRS FGTVATEPKL
70 80 90 100 110 120
FGGFNTSDTV TSPQRAGALA GGVTTFVALY DYESRTETDL SFKKGERLQI VNNTEGDWWL
130 140 150 160 170 180
AHSLTTGQTG YIPSNYVAPS DSIQAEEWYF GKITRRESER LLLNPENPRG TFLVRESETT
190 200 210 220 230 240
KGAYCLSVSD FDNAKGLNVK HYKIRKLDSG GFYITSRTQF SSLQQLVAYY SKHADGLCHR
250 260 270 280 290 300
LTNVCPTSKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT RVAIKTLKPG
310 320 330 340 350 360
TMSPEAFLQE AQVMKKLRHE KLVQLYAVVS EEPIYIVTEY MSKGSLLDFL KGEMGKYLRL
370 380 390 400 410 420
PQLVDMAAQI ASGMAYVERM NYVHRDLRAA NILVGENLVC KVADFGLARL IEDNEYTARQ
430 440 450 460 470 480
GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LLTELTTKGR VPYPGMVNRE VLDQVERGYR
490 500 510 520 530
MPCPPECPES LHDLMCQCWR KDPEERPTFE YLQAFLEDYF TSTEPQYQPG ENL