O96681

SS
Gene name
PlexA
Protein name
Plexin A
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
EC number
Protein Class

Descriptions

Plexin cell surface receptors bind to semaphorin ligands and transduce signals for regulating neuronal axon guidance. In mouse Plexin-A3 (P70208), the autoinhibitory region including an Rho GTPase-binding domain (RBD) makes extensive interactions with the GAP domain (C1 and C2 domains), which may enable it to regulate the GAP conformation in response to semaphorin binding. According to human Plexin-A1 study, the Sema domain may be also involved in autoinhibition.

Autoinhibitory domains (AIDs)

77-501 (Sema domain) SS

Target domain

1353-1916 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

1303-1384 (Segment preceding C1 domain) SS

Target domain

1353-1916 (Plexin, RasGAP domain)

Relief mechanism

Assay

1510-1742 (RBD domain) SS

Target domain

1353-1916 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for O96681

Entry ID Method Resolution Chain Position Source

No variants for O96681

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O96681

No associated diseases with O96681

15 regional properties for O96681

Type Name Position InterPro Accession
domain Sema domain 47 - 520 IPR001627
repeat Plexin repeat 522 - 568 IPR002165-1
repeat Plexin repeat 671 - 705 IPR002165-2
repeat Plexin repeat 830 - 883 IPR002165-3
domain IPT domain 884 - 976 IPR002909-1
domain IPT domain 977 - 1063 IPR002909-2
domain IPT domain 1065 - 1168 IPR002909-3
domain IPT domain 1194 - 1242 IPR002909-4
domain Plexin, cytoplasmic RasGAP domain 1353 - 1916 IPR013548
domain PSI domain 522 - 574 IPR016201-1
domain PSI domain 671 - 706 IPR016201-2
domain PSI domain 830 - 883 IPR016201-3
domain Plexin, TIG domain 1 581 - 670 IPR041019
domain Plexin, TIG domain 2 738 - 829 IPR041362
domain Plexin, cytoplasmic RhoGTPase-binding domain 1524 - 1647 IPR046800

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

5 GO annotations of molecular function

Name Definition
14-3-3 protein binding Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
guanylate cyclase activator activity Binds to and increases the activity of guanylate cyclase.
heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

12 GO annotations of biological process

Name Definition
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
axon midline choice point recognition The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of guanylate cyclase activity Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.
Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance.
semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance.
sensory neuron axon guidance The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNFVLSVLLI AILKDKYDYW LPSRTGCQTL AANIWSDKTT AQNEPINLTN ANAPIKNAKN
70 80 90 100 110 120
LNSTITNVAA FDTKLNHLLV DTITGRVFVG GVNRLYQLSP DLELSETVKT GPQNDSVECS
130 140 150 160 170 180
ILDCPLNAVR SPTDNYNKVL LIDRATSRLI ACGSLFQGTC TVRNLQNVSI IEHEVPDAVV
190 200 210 220 230 240
ANDANSSTVA FIAPGPPQHP VTNVMYVGVT YTNNSPYRSE IPAVASRSLE KTKMFQIASS
250 260 270 280 290 300
AVTTGTRTFI NSYARETYFV NYVYGFSSER FSYFLTTQLK HSHHSSPKEY ITKLVRICQE
310 320 330 340 350 360
DSNYYSYTEI PVECISDAQG GTKFNLVQAG FLGKPSSNLA QSLGISIQND VLFAVFSKGE
370 380 390 400 410 420
GNTPTNNSAL CIYSLKSIRR KFMQNIKSCF NGSGMRGLNF ISPSMPCVLT KLQTIGEDFC
430 440 450 460 470 480
GLDVNSPLGG ETPITSVPVA MFNTKLTSVA ATSTSGYTVV FVGTSDGFLK KVVIESSSIA
490 500 510 520 530 540
NEYASFAVDL GSEINRDMQF DNQNLYIYVM SKTKVSKVKV FDCSDYKTCG DCLGARDPYC
550 560 570 580 590 600
GWCSLENKCS PRSNCQDDAN DPFYWVSYKT GKCTTITSVV PHQLQRTTAR TLELIIDHLP
610 620 630 640 650 660
QLKENLICAF TTEDKALFTN ATKKRNGVNC TTPRTDMLPQ IEQGKHHFTA KLSVRTRNGP
670 680 690 700 710 720
DLVSTDFTFF DCSTHSSCTR CVSSEFPCDW CVEAHRCTHD TAENCRNDIL VTGVSRIGPS
730 740 750 760 770 780
YRSGPGFCPT INATGDGSEV LVAGGTSKSI KVKVHIIGQF IVQTRFVCQF NIEGRVTSLN
790 800 810 820 830 840
AQLLGDTIYC DSMEFQYTSR SPNLTATFAV IWGGSKPLDN PHNIHVVIYR CREMADSCGI
850 860 870 880 890 900
CLALSEKYNC GWCSSTNTCE VEEQCNKNKE GKTDWLNRSE ICPNPEIHTF QPKTGPWEGG
910 920 930 940 950 960
TNITIRGINL GKNYNDIYSG VRIAGINCMP FPQFYIDTKQ IVCTVDSPGE QMYRNGKIVV
970 980 990 1000 1010 1020
QIGDYRGESK EDYEFVDPKI LDFNPKFGPT SGGTEIHITG KHLNAGSRIQ ASINDHLPCK
1030 1040 1050 1060 1070 1080
ILSTDSSQAI CRTSASPGII EGRLKMSFDN GPREFNDYNF KYVLDPTVEH VSSGPSGQIK
1090 1100 1110 1120 1130 1140
VPKGIPAGGI RISVTGTQFT SIQNPNIYVV YNGEMYASPC RVQSDTEMEC ASPVVDVDSH
1150 1160 1170 1180 1190 1200
VIEAERPILL EYGFLMDNVL RVQNLSKVHN NHFELYPNPE YFIFEERVKY FKSXYLTING
1210 1220 1230 1240 1250 1260
RNLDRACKES DVEVKIGNGF CNITSLSRQQ LTCRPPSEAT ATKSMNGPEV IVRIGTSLEY
1270 1280 1290 1300 1310 1320
RIGILSYESS NIILDWGENV IFAVIATIVI LLLIFVALLV AYKKKSSESS RVLRNMQEQM
1330 1340 1350 1360 1370 1380
DILELRVAAE CKEAFAELQT EMTDLTGDLT SGGIPFLDYR SYAMKILFPN HEDHIVLQWE
1390 1400 1410 1420 1430 1440
RPELLRKEKG LRIFGQLIMN KTFLLLFIRT LESNRYFSMR ERVNVASLIM VTLQSKLEYC
1450 1460 1470 1480 1490 1500
TDILKTLLGD LIEKCIEGKS HPKLLLRRTE SVAEKMLSAW FTFLLYKFLK ECAGEPLYML
1510 1520 1530 1540 1550 1560
FRAVKGQVDK GPVDACTHEA RYSLSEEKLI RQSIDFRPMN VYASIIQQPI FCNNLDMLPS
1570 1580 1590 1600 1610 1620
HTENVSVKVL DCDTIGQVKE KCLETIYRNI PSSPRPPKDD LDLEWRTGAT GRVILYDEDV
1630 1640 1650 1660 1670 1680
TSKTESEWKK LNTLQHYNVP DGAGLSLVPK QSSIYNFSIL SDKNEKSHKY ETLNISKYTS
1690 1700 1710 1720 1730 1740
SSPTFSRAGS PLNNDMHENG LRYWHLVKHH DSDMQKEGER VNKLVSEIYL TRLLATKGTL
1750 1760 1770 1780 1790 1800
QKFVDDLFET IFSTAHRGSA LPLAIKYMFD FLDDQAQLHG ITDPEVVHTW KSNSLPLRFW
1810 1820 1830 1840 1850 1860
VNLIKNPNFV FDIHKSNIVD SCLSVVAQTF MDSCSTSDHR LGKDSPSSKL LYAKDIPEYR
1870 1880 1890 1900 1910 1920
KWVDRYYRDI RDMSPISDQD MNAMLAEESR LHTTEFNTNC ALHELYTYAV KYNEQLTVTL
1930 1940
EEDEFSQKQR LAFKLEQVHN IMSSE