O95755
Gene name |
RAB36 |
Protein name |
Ras-related protein Rab-36 |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:9609 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O95755
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O95755-F1 | Predicted | AlphaFoldDB |
3 variants for O95755
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
VAR_034433 rs9624036 |
50 | P>L | No |
UniProt dbSNP |
|
|
rs5759612 VAR_024189 CA410885775 |
308 | N>D | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
VAR_051715 CA10141568 rs9624038 |
320 | E>K | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
No associated diseases with O95755
1 regional properties for O95755
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 124 - 281 | IPR005225 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6QR46 | RAB6B | Ras-related protein Rab-6B | Bos taurus (Bovine) | PR |
| Q1KME6 | RAB6A | Ras-related protein Rab-6A | Gallus gallus (Chicken) | PR |
| O18334 | Rab6 | Ras-related protein Rab6 | Drosophila melanogaster (Fruit fly) | PR |
| Q5JT25 | RAB41 | Ras-related protein Rab-41 | Homo sapiens (Human) | PR |
| Q9NRW1 | RAB6B | Ras-related protein Rab-6B | Homo sapiens (Human) | PR |
| P20340 | RAB6A | Ras-related protein Rab-6A | Homo sapiens (Human) | PR |
| Q15771 | RAB30 | Ras-related protein Rab-30 | Homo sapiens (Human) | PR |
| O00194 | RAB27B | Ras-related protein Rab-27B | Homo sapiens (Human) | PR |
| P51159 | RAB27A | Ras-related protein Rab-27A | Homo sapiens (Human) | PR |
| Q9BZG1 | RAB34 | Ras-related protein Rab-34 | Homo sapiens (Human) | PR |
| P35279 | Rab6a | Ras-related protein Rab-6A | Mus musculus (Mouse) | PR |
| P61294 | Rab6b | Ras-related protein Rab-6B | Mus musculus (Mouse) | PR |
| Q8CAM5 | Rab36 | Ras-related protein Rab-36 | Mus musculus (Mouse) | PR |
| Q9WVB1 | Rab6a | Ras-related protein Rab-6A | Rattus norvegicus (Rat) | PR |
| P34213 | rab-6.1 | Ras-related protein rab-6.1 | Caenorhabditis elegans | PR |
| Q22782 | rab-6.2 | Ras-related protein rab-6.2 | Caenorhabditis elegans | PR |
| O80501 | RABH1B | Ras-related protein RABH1b | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SMR4 | RABH1C | Ras-related protein RABH1c | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFT9 | RABH1E | Ras-related protein RABH1e | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LV79 | RABH1A | Ras-related protein RABH1a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVIAGASWML | GRAAASPTQT | PPTTSTIRVA | RRSRVALVAM | VIAAAGSGGP | GRAEPQLSQP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLDCGRMRSS | LTPLGPPVSR | DRVIASFPKW | YTPEACLQLR | EHFHGQVSAA | CQRRNTGTVG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKLSKVVVVG | DLYVGKTSLI | HRFCKNVFDR | DYKATIGVDF | EIERFEIAGI | PYSLQIWDTA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GQEKFKCIAS | AYYRGAQVII | TAFDLTDVQT | LEHTRQWLED | ALRENEAGSC | FIFLVGTKKD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLSGAACEQA | EADAVHLARE | MQAEYWSVSA | KTGENVKAFF | SRVAALAFEQ | SVLQDLERQS |
| 310 | 320 | 330 | |||
| SARLQVGNGD | LIQMEGSPPE | TQESKRPSSL | GCC |